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https://www.readbyqxmd.com/read/27903672/-exertional-dyspnoea-in-copd-the-clinical-utility-of-cardiopulmonary-exercise-testing-denis-e-o-donnell-amany-f-elbehairy-azmy-faisal-katherine-a-webb-j-alberto-neder-and-donald-a-mahler-eur-respir-rev-2016-25-333-347
#1
(no author information available yet)
No abstract text is available yet for this article.
December 2016: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/27900530/erratum-to-the-dna-methyltransferase-inhibitor-zebularine-exerts-antitumor-effects-and-reveals-batf2-as-a-poor-prognostic-marker-for-childhood-medulloblastoma
#2
Augusto Faria Andrade, Kleiton Silva Borges, Veridiana Kiill Suazo, Lenisa Geron, Carolina Alves Pereira Corrêa, Angel Mauricio Castro-Gamero, Elton José Rosas de Vasconcelos, Ricardo Santos de Oliveira, Luciano Neder, José Andres Yunes, Simone Dos Santos Aguiar, Carlos Alberto Scrideli, Luiz Gonzaga Tone
No abstract text is available yet for this article.
November 29, 2016: Investigational New Drugs
https://www.readbyqxmd.com/read/27888114/limonene-reduces-hyperalgesia-induced-by-gp120-and-cytokines-by-modulation-of-il-1-%C3%AE-and-protein-expression-in-spinal-cord-of-mice
#3
Ana Claudia Piccinelli, Priscila Neder Morato, Marcelo Dos Santos Barbosa, Julio Croda, Jared Sampson, Xiangpeng Kong, Elisabete Castelon Konkiewitza, Edward B Ziff, Jaime Amaya-Farfan, Cândida Aparecida Leite Kassuya
AIMS: We have investigated the antihyperalgesic effects of limonene in mice that received intrathecal injection of gp120. MAIN METHODS: Male Swiss mice received gp120, IL-1β or TNF-α intrathecally or sterile saline as a control. A mechanicalsensitivity test was performed at 2 and 3h after the injection. Spinal cord and blood samples were isolated for protein quantification. KEY FINDINGS: Intrathecal administration of gp120 increased mechanical sensitivity measured with an electronic Von Frey apparatus, at 2 and 3h after the injections...
November 22, 2016: Life Sciences
https://www.readbyqxmd.com/read/27832235/influence-of-heart-failure-on-resting-lung-volumes-in-patients-with-copd
#4
Aline Soares de Souza, Priscila Abreu Sperandio, Adriana Mazzuco, Maria Clara Alencar, Flávio Ferlin Arbex, Mayron Faria de Oliveira, Denis Eunan O'Donnell, José Alberto Neder
Objective: To evaluate the influence of chronic heart failure (CHF) on resting lung volumes in patients with COPD, i.e., inspiratory fraction-inspiratory capacity (IC)/TLC-and relative inspiratory reserve-[1 - (end-inspiratory lung volume/TLC)]. Methods: This was a prospective study involving 56 patients with COPD-24 (23 males/1 female) with COPD+CHF and 32 (28 males/4 females) with COPD only-who, after careful clinical stabilization, underwent spirometry (with forced and slow maneuvers) and whole-body plethysmography...
July 2016: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
https://www.readbyqxmd.com/read/27824399/p27-cdkn1b-translational-regulators-in-pituitary-tumorigenesis
#5
C S Martins, R C Camargo, F P Saggioro, L Neder, H R Machado, A C Moreira, M de Castro
In pituitary tumors, P27(CDKN1B) is underexpressed. We aimed to clarify whether translational regulation underlies this phenomenon. This study evaluated the expression of P27/CDKN1B, its targets (CCNE1, CDK2) and translational regulators (DKC1, RPS13, miR221, miR222) and screened for DKC1 variants in sporadic pituitary adenomas. Samples were obtained during transsphenoidal surgery from 48 patients with pituitary adenomas: 10 ACTH-, 17 GH-secreting, and 21 nonfunctioning (NFPA). The control group comprised 7 normal pituitaries (NP) obtained during autopsies...
December 2016: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/27817818/clinical-usefulness-of-end-tidal-co2-profiles-during-incremental-exercise-in-patients-with-chronic-thromboembolic-pulmonary-hypertension
#6
R P Ramos, E V M Ferreira, F M Valois, A Cepeda, C M S Messina, R K Oliveira, A T V Araújo, C A Teles, J A Neder, L E Nery, J S Ota-Arakaki
INTRODUCTION: Great ventilation to carbon dioxide output (ΔV˙E/ΔV˙CO2) and reduced end-tidal partial pressures for CO2 (PetCO2) during incremental exercise are hallmarks of chronic thromboembolic pulmonary hypertension (CTEPH) and idiopathic pulmonary arterial hypertension (IPAH). However, CTEPH is more likely to involve proximal arteries, which may lead to poorer right ventricle-pulmonary vascular coupling and worse gas exchange abnormalities. Therefore, abnormal PetCO2 profiles during exercise may be more prominent in patients with CTEPH and could be helpful to indicate disease severity...
November 2016: Respiratory Medicine
https://www.readbyqxmd.com/read/27809198/celebrating-100-years-of-the-debye-scattering-equation
#7
Paolo Scardi, Simon J L Billinge, Reinhard Neder, Antonio Cervellino
One hundred years of the Debye scattering equation are celebrated with a series of articles arising from the DSE 2015 conference.
November 1, 2016: Acta Crystallographica. Section A, Foundations and Advances
https://www.readbyqxmd.com/read/27785591/the-dna-methyltransferase-inhibitor-zebularine-exerts-antitumor-effects-and-reveals-batf2-as-a-poor-prognostic-marker-for-childhood-medulloblastoma
#8
Augusto Faria Andrade, Kleiton Silva Borges, Veridiana Kiill Suazo, Lenisa Geron, Carolina Alves Pereira Corrêa, Angel Mauricio Castro-Gamero, Elton José Rosas de Vasconcelos, Ricardo Santos de Oliveira, Luciano Neder, José Andres Yunes, Simone Dos Santos Aguiar, Carlos Alberto Scrideli, Luiz Gonzaga Tone
Medulloblastoma (MB) is the most common solid tumor among pediatric patients and corresponds to 20 % of all pediatric intracranial tumors in this age group. Its treatment currently involves significant side effects. Epigenetic changes such as DNA methylation may contribute to its development and progression. DNA methyltransferase (DNMT) inhibitors have shown promising anticancer effects. The agent Zebularine acts as an inhibitor of DNA methylation and shows low toxicity and high efficacy, being a promising adjuvant agent for anti-cancer chemotherapy...
October 26, 2016: Investigational New Drugs
https://www.readbyqxmd.com/read/27784687/dietary-nitrate-supplementation-and-exercise-tolerance-in-patients-with-heart-failure-with-reduced-ejection-fraction
#9
Daniel M Hirai, Joel T Zelt, Joshua H Jones, Luiza G Castanhas, Robert F Bentley, Wendy Earle, Patti Staples, Michael E Tschakovsky, John McCans, Denis E O'Donnell, J Alberto Neder
Endothelial dysfunction and reduced nitric oxide (NO) signaling are key abnormalities leading to skeletal muscle oxygen delivery-utilization mismatch and poor physical capacity in patients with heart failure with reduced ejection fraction (HFrEF). Oral inorganic nitrate supplementation provides an exogenous source of NO that may enhance locomotor muscle function and oxygenation with consequent improvement in exercise tolerance in HFrEF. Thirteen patients (left ventricular ejection fraction ≤40%) were enrolled in a double-blind, randomized crossover study to receive concentrated nitrate-rich (nitrate) or nitrate-depleted (placebo) beetroot juice for 9 days...
October 26, 2016: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/27779551/does-exercise-ventilatory-inefficiency-predict-poor-outcome-in-heart-failure-patients-with-copd
#10
Maria Clara Alencar, Flavio F Arbex, Aline Souza, Adriana Mazzuco, Priscila A Sperandio, Alcides Rocha, Daniel M Hirai, Frederico Mancuso, Danilo C Berton, Audrey Borghi-Silva, Dirceu Almeida, Denis E OʼDonnel, J Alberto Neder
PURPOSE: To investigate whether the opposite effects of heart failure (HF) and chronic obstructive pulmonary disease (COPD) on exercise ventilatory inefficiency (minute ventilation [(Equation is included in full-text article.)E]-carbon dioxide output [(Equation is included in full-text article.)CO2] relationship) would negatively impact its prognostic relevance. METHODS: After treatment optimization and an incremental cardiopulmonary exercise test, 30 male patients with HF-COPD (forced expiratory volume in 1 second [FEV1] = 57% ± 17% predicted, ejection fraction = 35% ± 6%) were prospectively followed up during 412 ± 261 days for major cardiac events...
November 2016: Journal of Cardiopulmonary Rehabilitation and Prevention
https://www.readbyqxmd.com/read/27766905/chronic-breathlessness-in-patients-with-idiopathic-pulmonary-fibrosis-a-major-challenge-for-caregivers
#11
Denis E O'Donnell, J Alberto Neder, Ingrid Harle, Onofre Moran-Mendoza
Idiopathic pulmonary fibrosis (IPF) is one of the most common forms of interstitial lung disease, with a median survival time of two to five years. Most patients with IPF experience chronic breathlessness, which is closely linked to poor perceived quality of life and significant restriction of daily activities; therefore, effective management of this distressing symptom is a major goal of patient care. Areas covered: This report summarizes the physiology of IPF during rest and exercise, outlines current concepts of the mechanisms of breathlessness, and provides a physiological rationale for optimal management of individual patients...
December 2016: Expert Review of Respiratory Medicine
https://www.readbyqxmd.com/read/27735086/solving-the-hydrogen-and-lithium-substructure-of-poly-triazine-imide-licl-using-nmr-crystallography
#12
Maria B Mesch, Kilian Bärwinkel, Yaşar Krysiak, Charlotte Martineau, Francis Taulelle, Reinhard B Neder, Ute Kolb, Jürgen Senker
Poly(triazine imide) with incorporated lithium chloride has recently attracted substantial attention due to its photocatalytic activity for water splitting. However, an apparent H/Li disorder prevents the delineation of structure-property relationships, for example, with respect to band-gap tuning. Herein, we show that through a combination of one- and two-dimensional, multinuclear solid-state NMR spectroscopy, chemical modelling, automated electron diffraction tomography, and an analysis based on X-ray pair distribution functions, it is finally possible to resolve the H/Li substructure...
November 14, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/27701063/physiological-and-sensory-consequences-of-exercise-oscillatory-ventilation-in-heart-failure-copd
#13
Alcides Rocha, Flavio F Arbex, Maria Clara N Alencar, Priscila A Sperandio, Daniel M Hirai, Danilo C Berton, Denis E O'Donnell, J Alberto Neder
BACKGROUND: Exercise oscillatory ventilation (EOV) is associated with poor ventilatory efficiency and higher operating lung volumes in heart failure. These abnormalities may be particularly deleterious to dyspnea and exercise tolerance in mechanically-limited patients, e.g. those with coexistent COPD. METHODS: Ventilatory, gas exchange and sensory responses to incremental exercise were contrasted in 68 heart failure-COPD patients (12 EOV+). EOV was established by standard criteria...
September 24, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27658780/hox-genes-potential-candidates-for-the-progression-of-laryngeal-squamous-cell-carcinoma
#14
Rafaela de Barros E Lima Bueno, Anelisa Ramão, Daniel Guariz Pinheiro, Cleidson Padua Alves, Vinicius Kannen, Achim A Jungbluth, Luiza Ferreira de Araújo, Bruna Rodrigues Muys, Aline Simoneti Fonseca, Jessica Rodrigues Plaça, Rodrigo Alexandre Panepucci, Luciano Neder, Fabiano P Saggioro, Rui Celso M Mamede, David Livingstone Alves Figueiredo, Wilson Araújo Silva
Laryngeal squamous cell carcinoma (LSCC) is a very aggressive cancer, considered to be a subtype of the head and neck squamous cell carcinoma (HNSCC). Despite significant advances in the understanding and treatment of cancer, prognosis of patients with LSCC has not improved recently. In the present study, we sought to understand better the genetic mechanisms underlying LSCC development. Thirty-two tumor samples were collected from patients undergoing surgical resection of LSCC. The samples were submitted to whole-genome cDNA microarray analysis aiming to identify genetic targets in LSCC...
September 22, 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/27639286/is-the-six-minute-walk-test-a-useful-tool-to-prescribe-high-intensity-exercise-in-patients-with-chronic-obstructive-pulmonary-disease
#15
Antenor Rodrigues, Marianna Di Martino, Aline G Nellessen, Nidia A Hernandes, J Alberto Neder, Fabio Pitta
BACKGROUND: It is not yet completely known whether the 6MWT can be used to prescribe high-intensity exercise for patients with COPD. OBJECTIVE: To evaluate the ability of the six-minute walk test (6MWT) to prescribe high-intensity exercise for patients with chronic obstructive pulmonary disease (COPD). METHODS: Lung function, maximal inspiratory strength, symptoms and exercise capacity were evaluated in patients with COPD (n = 27) before and after a 12-week high-intensity exercise program...
September 14, 2016: Heart & Lung: the Journal of Critical Care
https://www.readbyqxmd.com/read/27581832/exertional-dyspnoea-in-copd-the-clinical-utility-of-cardiopulmonary-exercise-testing
#16
Denis E O'Donnell, Amany F Elbehairy, Azmy Faisal, Katherine A Webb, J Alberto Neder, Donald A Mahler
Activity-related dyspnoea is often the most distressing symptom experienced by patients with chronic obstructive pulmonary disease (COPD) and can persist despite comprehensive medical management. It is now clear that dyspnoea during physical activity occurs across the spectrum of disease severity, even in those with mild airway obstruction. Our understanding of the nature and source of dyspnoea is incomplete, but current aetiological concepts emphasise the importance of increased central neural drive to breathe in the setting of a reduced ability of the respiratory system to appropriately respond...
September 2016: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/27547741/indeterminate-cell-histiocytosis-successfully-treated-with-phototherapy
#17
Maria Claudia Nogueira Zerbini, Mirian Nacagami Sotto, Fernando Peixoto Ferraz de Campos, Andre Neder Ramires Abdo, Juliana Pereira, José Antônio Sanches, Jade Cury Martins
First described in 1985, intermediate cell histiocytosis is a rare disorder of the cutaneous dendritic cell group with a varied clinical presentation and evolution. The pathologic substrate is constituted by the proliferation of indeterminate cells (ICs) that are immunophenotypically characterized by the positivity of CD1a, CD68, and faint/focal S100, plus the negativity for CD207 (langerin). The authors present the case of a healthy elderly woman who presented generalized dome-shaped reddish cutaneous nodules over her trunk, neck, face, and extremities over a period of 18 months...
April 2016: Autopsy & case reports
https://www.readbyqxmd.com/read/27537864/physicochemical-changes-and-resistant-starch-content-of-extruded-cornstarch-with-and-without-storage-at-refrigerator-temperatures
#18
David Neder-Suárez, Carlos A Amaya-Guerra, Armando Quintero-Ramos, Esther Pérez-Carrillo, María G de J Alanís-Guzmán, Juan G Báez-González, Carlos L García-Díaz, María A Núñez-González, Daniel Lardizábal-Gutiérrez, Jorge A Jiménez-Castro
Effects of extrusion cooking and low-temperature storage on the physicochemical changes and resistant starch (RS) content in cornstarch were evaluated. The cornstarch was conditioned at 20%-40% moisture contents and extruded in the range 90-130 °C and at screw speeds in the range 200-360 rpm. The extrudates were stored at 4 °C for 120 h and then at room temperature. The water absorption, solubility index, RS content, viscoelastic, thermal, and microstructural properties of the extrudates were evaluated before and after storage...
2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27521776/cerebral-microvascular-blood-flow-and-co2-reactivity-in-pulmonary-arterial-hypertension
#19
Erika Treptow, Mayron F Oliveira, Aline Soares, Roberta P Ramos, Luiz Medina, Rita Lima, Maria Clara Alencar, Eloara Vieira Ferreira, Jaquelina S Ota-Arakaki, Sergio Tufik, Luiz E Nery, Lia Rita Bittencourt, J Alberto Neder
Hypocapnia and endothelial dysfunction might impair microvascular cerebral blood flow (CBFmicr) and cerebrovascular reactivity to CO2 (CVRCO2). Pulmonary arterial hypertension (PAH) is characteristically associated with chronic alveolar hyperventilation and microvascular endothelial dysfunction. We therefore determined CBFmicr (pre-frontal blood flow index (BFI) by the indocyanine green-near infrared spectroscopy methodology) during hypocapnia and hypercapnia in 25 PAH patients and 10 gender- and age-matched controls...
November 2016: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/27492828/mechanisms-of-exertional-dyspnoea-in-symptomatic-smokers-without-copd
#20
Amany F Elbehairy, Jordan A Guenette, Azmy Faisal, Casey E Ciavaglia, Katherine A Webb, Dennis Jensen, Andrew H Ramsook, J Alberto Neder, Denis E O'Donnell
Dyspnoea and activity limitation can occur in smokers who do not meet spirometric criteria for chronic obstructive pulmonary disease (COPD) but the underlying mechanisms are unknown.Detailed pulmonary function tests and sensory-mechanical relationships during incremental exercise with respiratory pressure measurements and diaphragmatic electromyography (EMGdi) were compared in 20 smokers without spirometric COPD and 20 age-matched healthy controls.Smokers (mean±sd post-bronchodilator forced expiratory volume in 1 s (FEV1)/forced vital capacity 75±4%, mean±sd FEV1 104±14% predicted) had greater activity-related dyspnoea, poorer health status and lower physical activity than controls...
September 2016: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
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