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https://www.readbyqxmd.com/read/29625497/impact-of-the-canonical-wnt-pathway-activation-on-the-pathogenesis-and-prognosis-of-adamantinomatous-craniopharyngiomas
#1
Carlos Eduardo Barros Jucá, Leandro Machado Colli, Clarissa Silva Martins, Marina Lanciotti Campanini, Beatriz Paixão, Renata Viana Jucá, Fabiano Pinto Saggioro, Ricardo Santos de Oliveira, Ayrton Custódio Moreira, Hélio Rubens Machado, Luciano Neder, Sonir Rauber Antonini, Margaret de Castro
CTNNB1 mutations and abnormal β-catenin distribution are associated with the pathogenesis of adamantinomatous craniopharyngioma (aCP). We evaluated the expression of the canonical Wnt pathway components in aCPs and its association with CTNNB1 mutations and tumor progression. Tumor samples from 14 aCP patients and normal anterior pituitary samples from eight individuals without pituitary disease were studied. Gene expression of Wnt pathway activator ( WNT4 ), inhibitors ( SFRP1 , DKK3 , AXIN1 , and APC ), transcriptional activator ( TCF7 ), target genes ( MYC , WISP2 , and, CDH1 ), and Wnt modulator ( TP53 ) was evaluated by qPCR...
April 6, 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/29582271/reduced-hydroxymethylation-characterizes-medulloblastoma-while-tet-and-idh-genes-are-differentially-expressed-within-molecular-subgroups
#2
Karina Bezerra Salomão, Gustavo Alencastro Veiga Cruzeiro, Ricardo Bonfim-Silva, Lenisa Geron, Fernando Ramalho, Fabiano Pinto Saggioro, Luciano Neder Serafini, Daniel Antunes Moreno, Rosane Gomes de Paula Queiroz, Simone Dos Santos Aguiar, Izilda Cardinalli, José Andres Yunes, Silvia Regina Brandalise, Maria Sol Brassesco, Carlos Alberto Scrideli, Luiz Gonzaga Tone
INTRODUCTION: Medulloblastoma (MB) is an embryonal tumour that originates from genetic deregulation of cerebellar developmental pathways and is classified into 4 molecular subgroups: SHH, WNT, group 3, and group 4. Hydroxymethylation levels progressively increases during cerebellum development suggesting a possibility of deregulation in MB pathogenesis. The aim of this study was to investigate global hydroxymethylation levels and changes in TET and IDH gene expression in MB samples compared to control cerebellum samples...
March 26, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29578103/acute-bronchodilator-therapy-does-not-reduce-wasted-ventilation-during-exercise-in-copd
#3
Amany F Elbehairy, Katherine A Webb, Pierantonio Laveneziana, Nicolle J Domnik, J Alberto Neder, Denis E O'Donnell
This randomized, double-blind, crossover study aimed to determine if acute treatment with inhaled bronchodilators, by improving regional lung hyperinflation and ventilation distribution, would reduce dead space-to-tidal volume ratio (VD /VT ); thus contributing to improved exertional dyspnea in COPD. Twenty COPD patients (FEV1  = 50 ± 15%predicted;mean ± SD) performed pulmonary function tests and symptom-limited constant-work rate exercise at 75% peak-work rate (with arterialized capillary blood gases) after nebulized bronchodilator (BD;ipratropium 0...
March 22, 2018: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/29543134/inspiratory-muscle-training-reduces-diaphragm-activation-and-dyspnea-during-exercise-in-copd
#4
Daniel Langer, Casey E Ciavaglia, Azmy Faisal, Katherine A Webb, J Alberto Neder, Rik Gosselink, Sauwaluk Dacha, Marko Topalovic, Anna Ivanova, Denis E O'Donnell
Among patients with COPD, those with the lowest maximal inspiratory pressures experience greater breathing discomfort (dyspnea) during exercise. In such individuals, inspiratory muscle training (IMT) may be associated with improvement of dyspnea but the mechanisms for this are poorly understood. Therefore, we aimed to identify physiological mechanisms of improvement in dyspnea and exercise endurance following inspiratory muscle training (IMT) in patients with COPD and low maximal inspiratory pressure (Pi,max)...
March 15, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29501244/systemic-vascular-dysfunction-is-associated-with-emphysema-burden-in-mild-copd
#5
Joel T Zelt, Joshua H Jones, Daniel M Hirai, Trevor J King, Danilo C Berton, Kyra E Pyke, Denis E O'Donnell, J Alberto Neder
BACKGROUND: Cardiovascular diseases play a major role in morbidity and mortality in the earlier stages of COPD. We hypothesized that systemic vascular dysfunction would be present even in patients who are currently considered at "low-risk" for negative cardiovascular outcomes, i.e., those with largely preserved FEV1 , few exacerbations and only mild burden of respiratory symptoms (GOLD spirometric grade 1, clinical group A). METHODS: 16 patients (FEV1  = 86 ± 13%) and 16 age- and gender-matched controls underwent measurements of: a) central arterial stiffness by pulse wave velocity, b) brachial flow-mediated dilation and c) forearm muscle oxygenation by near-infrared spectroscopy...
March 2018: Respiratory Medicine
https://www.readbyqxmd.com/read/29493538/ab-initio-structure-determination-and-quantitative-disorder-analysis-on-nanoparticles-by-electron-diffraction-tomography
#6
Yaşar Krysiak, Bastian Barton, Bernd Marler, Reinhard B Neder, Ute Kolb
Nanoscaled porous materials such as zeolites have attracted substantial attention in industry due to their catalytic activity, and their performance in sorption and separation processes. In order to understand the properties of such materials, current research focuses increasingly on the determination of structural features beyond the averaged crystal structure. Small particle sizes, various types of disorder and intergrown structures render the description of structures at atomic level by standard crystallographic methods difficult...
March 1, 2018: Acta Crystallographica. Section A, Foundations and Advances
https://www.readbyqxmd.com/read/29485343/a-simplified-approach-to-select-exercise-endurance-intensity-for-interventional-studies-in-copd
#7
Luiza H Degani-Costa, Denis E O'Donnell, Katherine Webb, Liliane C Aranda, Júlio P Carlstron, Tamires da Silva Cesar, Franciele Plachi, Danilo C Berton, J Alberto Neder, Luiz E Nery
Time to exercise limitation (Tlim) in response to constant work rate (CWR) is sensitive to interventions in chronic obstructive pulmonary disease (COPD). This is particularly true when the pre-intervention test lasts between 3 and 8 min (Tlim3'-8' ). There is, however, no simple method to select a work rate which is consistently associated with Tlim3'-8' across the spectrum of COPD severity. We assessed 59 GOLD stages II-IV patients who initially cycled to Tlim at 75% peak. In case of short (<3 min, low-endurance) or long (>8 min, high-endurance) tests, patients exercised after 60 min at 50% or 90%, respectively (CWR50%⇐75%⇒90% )...
February 27, 2018: COPD
https://www.readbyqxmd.com/read/29463343/characteristics-associated-with-mortality-in-patients-with-chronic-obstructive-pulmonary-disease-copd-heart-failure-coexistence
#8
Franciele Plachi, Fernanda M Balzan, Renata A Sanseverino, Dora V Palombini, Renata D Marques, Nadine O Clausell, Marli M Knorst, J Alberto Neder, Danilo C Berton
Aim To investigate if cardiac/pulmonary functional tests and variables obtained from clinical practice (body mass index, dyspnea, functional class, clinical judgment of disability to perform an exercise test and previous hospitalization rate) are related to mortality in patients with overlap chronic obstructive pulmonary disease (COPD) and chronic heart failure (CHF). BACKGROUND: Although the coexistence of COPD and CHF has been growingly reported, description of survival predictors considering the presence of both conditions is still scarce...
February 21, 2018: Primary Health Care Research & Development
https://www.readbyqxmd.com/read/29452026/general-movements-and-motor-outcomes-in-two-infants-exposed-to-zika-virus-brief-report
#9
Daniele de Almeida Soares-Marangoni, Natália Matos Tedesco, Andressa Lagoa Nascimento, Priscila Rimoli De Almeida, Caroline Neder Dos Santos Pereira
OBJECTIVE: We described the general movements (GMs) in the fidgety period and the motor performance of two infants who were exposed to Zika virus (ZIKV) during distinct trimesters of gestation. METHODS: Infants were assessed at 4 and 12 months of age. Prechtl's GM assessment and the Alberta Infant Motor Scale were used. RESULTS: In Case 1, the mother presented confirmed ZIKV infection in the 10th week of gestation and the infant was born full-term with brain abnormalities and microcephaly...
February 16, 2018: Developmental Neurorehabilitation
https://www.readbyqxmd.com/read/29412377/tuberculosis-and-latent-infection-in-employees-of-different-prison-unit-types
#10
Péricles Alves Nogueira, Regina Maura Cabral de Melo Abrahão, Vera Maria Neder Galesi, Rossana Verónica Mendoza López
OBJECTIVE: Estimate the prevalence of active tuberculosis and latent tuberculosis infection among the staff that is in contact and the staff that is not in contact with prisoners, and investigate factors associated with latent tuberculosis infection in this population. METHODS: Observational cross-sectional study, conducted from 2012 to 2015, in employees of different prison units in the municipality of Franco da Rocha, SP. It consisted of the application of a questionnaire, application and reading of the tuberculin test, sputum smear microscopy, sputum culture, and radiological examination...
February 5, 2018: Revista de Saúde Pública
https://www.readbyqxmd.com/read/29382565/excess-ventilation-in-copd-implications-for-dyspnoea-and-tolerance-to-interval-exercise
#11
Daniela M Bravo, Ana Cristina Gimenes, Beatriz C Amorim, Maria Clara Alencar, Danilo Berton, Denis E O'Donnell, Luiz E Nery, J Alberto Neder
Interval exercise delays critical mechanical-ventilatory constraints with positive consequences on dyspnea and exercise tolerance in COPD. We hypothesized that those advantages of interval exercise would be partially off-set in patients showing excessive ventilation (V̇E) to metabolic demand (V̇CO2). Sixteen men (FEV1 = 42.3 ± 8.9%) performed, on different days, 30 s and 60 s bouts at 100% peak (on) interspersed by moderate exercise at 40% (off). Nine patients did not sustain exercise for 30 min irrespective of on duration...
January 27, 2018: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/29368399/do-interindividual-differences-in-cardiac-output-during-submaximal-exercise-explain-differences-in-exercising-muscle-oxygenation-and-ratings-of-perceived-exertion
#12
Robert F Bentley, Joshua H Jones, Daniel M Hirai, Joel T Zelt, Matthew D Giles, James P Raleigh, Joe Quadrilatero, Brendon J Gurd, J Alberto Neder, Michael E Tschakovsky
Considerable interindividual differences in the Q˙-V˙O2 relationship during exercise have been documented but implications for submaximal exercise tolerance have not been considered. We tested the hypothesis that these interindividual differences were associated with differences in exercising muscle deoxygenation and ratings of perceived exertion (RPE) across a range of submaximal exercise intensities. A total of 31 (21 ± 3 years) healthy recreationally active males performed an incremental exercise test to exhaustion 24 h following a resting muscle biopsy...
January 2018: Physiological Reports
https://www.readbyqxmd.com/read/29331407/decreased-health-related-quality-of-life-in-children-and-adolescents-with-autoimmune-hepatitis
#13
Ana Beatriz Bozzini, Luciana Neder, Clovis A Silva, Gilda Porta
OBJECTIVE: The objective of this study was to evaluate the health-related quality of life in children and adolescents with autoimmune hepatitis. METHODS: A cross-sectional assessment with the Pediatric Quality of Life Inventory 4.0 (PedsQL 4.0) was completed for 80 patients with autoimmune hepatitis and 45 healthy controls. Demographic data, prednisone dose, disease remission state, disease severity, and abdominal pain were also evaluated. RESULTS: Based on the child self-reports, physical, emotional, school, and total scores were significantly lower in autoimmune hepatitis patients when compared with controls (p<0...
January 10, 2018: Jornal de Pediatria
https://www.readbyqxmd.com/read/29236891/high-expression-of-xiap-and-bcl-2-may-inhibit-programmed-cell-death-in-glioblastomas
#14
Daniela Pretti da Cunha Tirapelli, Isis Lacrose Lustosa, Sarah Bomfim Menezes, Indira Maynart Franco, Andressa Romualdo Rodrigues, Fernanda Maris Peria, Alexandre Magno da Nóbrega Marinho, Luciano Neder Serafini, Carlos Gilberto Carlotti, Luís Fernando Tirapelli
Glioblastoma (GBM) is the most malignant glioma and represents 29% of all brain tumors. Tumorigenesis is intimately connected with characteristics acquired in the physiologic pathway of cellular death. OBJECTIVE: In the present study, the expression of anti-apoptotic (XIAP and Bcl-2) and apoptotic (cytochrome C, caspase 9, APAF-1), caspase 3 and the Smac/DIABLO genes related to the apoptosis pathway were evaluated in 30 samples of glioblastoma. METHODS: The gene expression was evaluated in 30 glioblastomas (WHO grade IV) and compared to 10 white matter control samples with real-time PCR...
December 2017: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/29219330/favorable-concurrence-of-static-and-dynamic-phenomena-at-the-morphotropic-phase-boundary-of-xbini_-0-5-zr_-0-5-o_-3-1-x-pbtio_-3
#15
K Datta, R B Neder, J Chen, J C Neuefeind, B Mihailova
We reveal that concurrent events of inherent entropy boosting and increased synchronization between A- and B-site cation vibrations of an ABO_{3}-type perovskite structure give rise to a larger piezoelectric response in a ferroelectric system at its morphotropic phase boundary (MPB). It is further evident that the superior piezoelectric properties of xBiNi_{0.5}Zr_{0.5}O_{3}-(1-x)PbTiO_{3} in comparison to xBiNi_{0.5}Ti_{0.5}O_{3}-(1-x)PbTiO_{3} are due to the absolute flattening of the local potentials for all ferroelectrically active cations with a higher spontaneous polarization at the MPB...
November 17, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29192822/unraveling-the-cause-of-severe-exertional-dyspnea-in-a-heavy-smoker
#16
Amany F Elbehairy, Karlo Hockmann, Casey E Ciavaglia, Azmy Faisal, Elizabeth Hill, Katherine A Webb, J Alberto Neder, Denis E O'Donnell
No abstract text is available yet for this article.
December 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29175351/prevalence-associated-factors-outcomes-and-transmission-of-extensively-drug-resistant-tuberculosis-among-multidrug-resistant-tuberculosis-patients-in-s%C3%A3-o-paulo-brazil-a-cross-sectional-study
#17
J F Gallo, J M W Pinhata, V Simonsen, V M N Galesi, L Ferrazoli, R S Oliveira
OBJECTIVES: To describe the prevalence, associated factors, treatment outcomes and transmission of extensively drug-resistant (XDR) tuberculosis (TB) in the state of São Paulo, Brazil, for 2011 to 2013. METHODS: Drug susceptibility testing to first- and second-line drugs was performed by BACTEC MGIT 960 and molecular typing, by IS6110 restriction fragment length polymorphism. Clinical, epidemiologic and demographic data were obtained from surveillance information systems for TB...
November 22, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29163685/expression-of-cancer-testis-antigens-mage-a-mage-c1-gage-and-ctag1b-in-benign-and-malignant-thyroid-diseases
#18
Daniel Hardy Melo, Rui Celso Martins Mamede, Luciano Neder, Wilson Araújo Silva, Mateus Camargo Barros-Filho, Luiz Paulo Kowalski, Clóvis Antonio Lopes Pinto, Marco Antônio Zago, David Livingstone Alves Figueiredo, Achim A Jungbluth
Despite considerable advances in the understanding of thyroid gland biology, correctly diagnosing thyroid nodules and treating high-grade thyroid carcinoma remains challenging. Cancer/testis (CT) antigens have emerged as potential diagnostic tools as well as targets of potential cancer vaccinations. In the present study, a total of 117 patients who underwent surgical therapy for thyroid disease were available for analysis. The expression levels of melanoma-associated antigen (MAGE) A, MAGE-C1/CT7, cancer/testis antigen 1B (CTAG1B) and G antigen (GAGE) were analyzed by immunohistochemistry...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/28993264/sensory-mechanical-effects-of-a-dual-bronchodilator-and-its-anticholinergic-component-in-copd
#19
Denis E O'Donnell, Amany F Elbehairy, Azmy Faisal, J Alberto Neder, Katherine A Webb
This randomized, double-blind, crossover study examined the physiological rationale for using a dual long-acting bronchodilator (umeclidinium/vilanterol (UME/VIL)) versus its muscarinic-antagonist component (UME) as treatment for dyspnea and exercise intolerance in moderate COPD. After each 4-week treatment period, subjects performed pulmonary function and symptom-limited constant-work rate cycling tests with diaphragm electromyogram (EMGdi), esophageal (Pes), gastric (Pga) and transdiaphragmatic (Pdi) pressure measurements...
January 2018: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/28977120/a-practical-approach-to-assess-leg-muscle-oxygenation-during-ramp-incremental-cycle-ergometry-in-heart-failure
#20
A C Barroco, P A Sperandio, M Reis, D R Almeida, J A Neder
Heart failure is characterized by the inability of the cardiovascular system to maintain oxygen (O2) delivery (i.e., muscle blood flow in non-hypoxemic patients) to meet O2 demands. The resulting increase in fractional O2 extraction can be non-invasively tracked by deoxygenated hemoglobin concentration (deoxi-Hb) as measured by near-infrared spectroscopy (NIRS). We aimed to establish a simplified approach to extract deoxi-Hb-based indices of impaired muscle O2 delivery during rapidly-incrementing exercise in heart failure...
October 2, 2017: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
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