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Mariane Moreira Ramiro do Carmo, Ulana Chaves Sarmento, Leandro Fontoura Cavalheiro, Anderson Fernandes, Wander Fernando de Oliveira Filiú, Karine de Cássia Freitas Gielow, Deiler Sampaio Costa, Adriana Conceiçon Guercio, Valter Aragão do Nascimento, Camila Fontoura Acosta Ribeiro, Alinne Pereira de Castro, Cristiano Marcelo Espinola Carvalho, Daiana Novello, Valfredo de Almeida Santos-Junior, Priscila Neder Morato, Jaime Amaya-Farfan, Priscila Aiko Hiane, Elisvânia Freitas Dos Santos
Polydextrose (PDX) ingestion may increase the intestinal absorption of iron. This study evaluated the effects of 7.5% polydextrose supplementation on markers of iron uptake, transport and storage in partially gastrectomized rats. Half of a batch of 40 male Wistar rats (250 g) underwent Billroth II partial gastrectomy with anterior truncal vagotomy (GXT), while the other half underwent sham gastrectomy (SHAM). At 7 postoperative days, the animals were subdivided into four groups ( n = 10): Sham Control and GXT Control (no polydextrose); Sham PDX and GXT PDX (with 7...
June 20, 2018: Nutrients
Hugo Valverde Reis, Priscila Abreu Sperandio, Clynton Lourenço Correa, Solange Guizilini, José Alberto Neder, Audrey Borghi-Silva, Michel Silva Reis
OBJECTIVE: The aim of this study is to characterize the presence of exercise oscillatory ventilation (EOV) and to relate it with other cardiopulmonary exercise test (CET) responses and clinical variables. METHODS: Forty-six male patients (age: 53.1±13.6 years old; left ventricular ejection fraction [LVEF]: 30±8%) with heart failure were recruited to perform a maximal CET and to correlate the CET responses with clinical variables. The EOV was obtained according to Leite et al...
March 2018: Brazilian Journal of Cardiovascular Surgery
Niele D Mendes, Artur Fernandes, Glaucia M Almeida, Luis E Santos, Maria Clara Selles, Natalia Lyra-Silva, Carla M Machado, José A C Horta-Júnior, Paulo R Louzada, Fernanda G De Felice, Soniza Alvez-Leon, Jorge Marcondes, João Alberto Assirati, Caio M Matias, William L Klein, Norberto Garcia-Cairasco, Sergio T Ferreira, Luciano Neder, Adriano Sebollela
BACKGROUND: Slice cultures have been prepared from several organs. With respect to the brain, advantages of slice cultures over dissociated cell cultures include maintenance of the cytoarchitecture and neuronal connectivity. Slice cultures from adult human brain have been reported and constitute a promising method to study neurological diseases. Despite this potential, few studies have characterized in detail cell survival and function along time in short-term, free-floating cultures...
May 31, 2018: Journal of Neuroscience Methods
Carolina Soares Moura, Pablo Christiano Barboza Lollo, Priscila Neder Morato, Jaime Amaya-Farfan
Interest in the heat shock proteins (HSPs), as a natural physiological toolkit of living organisms, has ranged from their chaperone function in nascent proteins to the remedial role following cell stress. As part of the defence system, HSPs guarantee cell tolerance against a variety of stressors, including exercise, oxidative stress, hyper and hypothermia, hyper and hypoxia and improper diets. For the past couple of decades, research on functional foods has revealed a number of substances likely to trigger cell protection through mechanisms that involve the induction of HSP expression...
May 28, 2018: Nutrients
Anat Akiva, Maayan Neder, Keren Kahil, Rotem Gavriel, Iddo Pinkas, Gil Goobes, Tali Mass
Aragonite skeletons in corals are key contributors to the storage of atmospheric CO2 worldwide. Hence, understanding coral biomineralization/calcification processes is crucial for evaluating and predicting the effect of environmental factors on this process. While coral biomineralization studies have focused on adult corals, the exact stage at which corals initiate mineralization remains enigmatic. Here, we show that minerals are first precipitated as amorphous calcium carbonate and small aragonite crystallites, in the pre-settled larva, which then evolve into the more mature aragonitic fibers characteristic of the stony coral skeleton...
May 14, 2018: Nature Communications
Giancarlo Fatobene, Julien Haroche, Zofia Hélias-Rodzwicz, Frédéric Charlotte, Valérie Taly, Aliana Meneses Ferreira, André Néder Ramires Abdo, Vanderson Rocha, Jean-François Emile
No abstract text is available yet for this article.
May 10, 2018: Haematologica
James P Raleigh, Matthew D Giles, Hashim Islam, Matthew William Nelms, Robert F Bentley, Joshua H Jones, J Alberto Neder, Kristen Boonstra, Joe Quadrilatero, Craig A Simpson, Michael E Tschakovsky, Brendon J Gurd
The current study examined the contribution of central and peripheral adaptations to changes in maximal oxygen uptake (VO<sub>2</sub>max) following sprint interval training (SIT). Twenty-three males completed four weekly SIT sessions (8 x 20 second cycling bouts at ~170% of work rate at VO<sub>2</sub>max, 10 second recovery) for four weeks. Following completion of training, the relationship between changes in VO<sub>2</sub>max and changes in central (cardiac output) and peripheral (a-vO<sub>2</sub>diff, muscle capillary density, oxidative capacity, fibre-type distribution) adaptations was determined in all participants using correlation analysis...
May 7, 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
Carlos Eduardo Barros Jucá, Leandro Machado Colli, Clarissa Silva Martins, Marina Lanciotti Campanini, Beatriz Paixão, Renata Viana Jucá, Fabiano Pinto Saggioro, Ricardo Santos de Oliveira, Ayrton Custódio Moreira, Hélio Rubens Machado, Luciano Neder, Sonir Rauber Antonini, Margaret de Castro
CTNNB1 mutations and abnormal β-catenin distribution are associated with the pathogenesis of adamantinomatous craniopharyngioma (aCP). We evaluated the expression of the canonical Wnt pathway components in aCPs and its association with CTNNB1 mutations and tumor progression. Tumor samples from 14 aCP patients and normal anterior pituitary samples from eight individuals without pituitary disease were studied. Gene expression of Wnt pathway activator ( WNT4 ), inhibitors ( SFRP1 , DKK3 , AXIN1 , and APC ), transcriptional activator ( TCF7 ), target genes ( MYC , WISP2 , and, CDH1 ), and Wnt modulator ( TP53 ) was evaluated by qPCR...
April 6, 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
Karina Bezerra Salomão, Gustavo Alencastro Veiga Cruzeiro, Ricardo Bonfim-Silva, Lenisa Geron, Fernando Ramalho, Fabiano Pinto Saggioro, Luciano Neder Serafini, Daniel Antunes Moreno, Rosane Gomes de Paula Queiroz, Simone Dos Santos Aguiar, Izilda Cardinalli, José Andres Yunes, Silvia Regina Brandalise, Maria Sol Brassesco, Carlos Alberto Scrideli, Luiz Gonzaga Tone
INTRODUCTION: Medulloblastoma (MB) is an embryonal tumour that originates from genetic deregulation of cerebellar developmental pathways and is classified into 4 molecular subgroups: SHH, WNT, group 3, and group 4. Hydroxymethylation levels progressively increases during cerebellum development suggesting a possibility of deregulation in MB pathogenesis. The aim of this study was to investigate global hydroxymethylation levels and changes in TET and IDH gene expression in MB samples compared to control cerebellum samples...
March 26, 2018: Journal of Neuro-oncology
Amany F Elbehairy, Katherine A Webb, Pierantonio Laveneziana, Nicolle J Domnik, J Alberto Neder, Denis E O'Donnell
This randomized, double-blind, crossover study aimed to determine if acute treatment with inhaled bronchodilators, by improving regional lung hyperinflation and ventilation distribution, would reduce dead space-to-tidal volume ratio (VD /VT ); thus contributing to improved exertional dyspnea in COPD. Twenty COPD patients (FEV1  = 50 ± 15% predicted; mean ± SD) performed pulmonary function tests and symptom-limited constant-work rate exercise at 75% peak-work rate (with arterialized capillary blood gases) after nebulized bronchodilator (BD; ipratropium 0...
June 2018: Respiratory Physiology & Neurobiology
Daniel Langer, Casey E Ciavaglia, Azmy Faisal, Katherine A Webb, J Alberto Neder, Rik Gosselink, Sauwaluk Dacha, Marko Topalovic, Anna Ivanova, Denis E O'Donnell
Among patients with COPD, those with the lowest maximal inspiratory pressures experience greater breathing discomfort (dyspnea) during exercise. In such individuals, inspiratory muscle training (IMT) may be associated with improvement of dyspnea but the mechanisms for this are poorly understood. Therefore, we aimed to identify physiological mechanisms of improvement in dyspnea and exercise endurance following inspiratory muscle training (IMT) in patients with COPD and low maximal inspiratory pressure (Pi,max)...
March 15, 2018: Journal of Applied Physiology
Joel T Zelt, Joshua H Jones, Daniel M Hirai, Trevor J King, Danilo C Berton, Kyra E Pyke, Denis E O'Donnell, J Alberto Neder
BACKGROUND: Cardiovascular diseases play a major role in morbidity and mortality in the earlier stages of COPD. We hypothesized that systemic vascular dysfunction would be present even in patients who are currently considered at "low-risk" for negative cardiovascular outcomes, i.e., those with largely preserved FEV1 , few exacerbations and only mild burden of respiratory symptoms (GOLD spirometric grade 1, clinical group A). METHODS: 16 patients (FEV1  = 86 ± 13%) and 16 age- and gender-matched controls underwent measurements of: a) central arterial stiffness by pulse wave velocity, b) brachial flow-mediated dilation and c) forearm muscle oxygenation by near-infrared spectroscopy...
March 2018: Respiratory Medicine
Yaşar Krysiak, Bastian Barton, Bernd Marler, Reinhard B Neder, Ute Kolb
Nanoscaled porous materials such as zeolites have attracted substantial attention in industry due to their catalytic activity, and their performance in sorption and separation processes. In order to understand the properties of such materials, current research focuses increasingly on the determination of structural features beyond the averaged crystal structure. Small particle sizes, various types of disorder and intergrown structures render the description of structures at atomic level by standard crystallographic methods difficult...
March 1, 2018: Acta Crystallographica. Section A, Foundations and Advances
Luiza H Degani-Costa, Denis E O'Donnell, Katherine Webb, Liliane C Aranda, Júlio P Carlstron, Tamires da Silva Cesar, Franciele Plachi, Danilo C Berton, J Alberto Neder, Luiz E Nery
Time to exercise limitation (Tlim) in response to constant work rate (CWR) is sensitive to interventions in chronic obstructive pulmonary disease (COPD). This is particularly true when the pre-intervention test lasts between 3 and 8 min (Tlim3'-8' ). There is, however, no simple method to select a work rate which is consistently associated with Tlim3'-8' across the spectrum of COPD severity. We assessed 59 GOLD stages II-IV patients who initially cycled to Tlim at 75% peak. In case of short (<3 min, low-endurance) or long (>8 min, high-endurance) tests, patients exercised after 60 min at 50% or 90%, respectively (CWR50%⇐75%⇒90% )...
February 27, 2018: COPD
Franciele Plachi, Fernanda M Balzan, Renata A Sanseverino, Dora V Palombini, Renata D Marques, Nadine O Clausell, Marli M Knorst, J Alberto Neder, Danilo C Berton
Aim To investigate if cardiac/pulmonary functional tests and variables obtained from clinical practice (body mass index, dyspnea, functional class, clinical judgment of disability to perform an exercise test and previous hospitalization rate) are related to mortality in patients with overlap chronic obstructive pulmonary disease (COPD) and chronic heart failure (CHF). BACKGROUND: Although the coexistence of COPD and CHF has been growingly reported, description of survival predictors considering the presence of both conditions is still scarce...
February 21, 2018: Primary Health Care Research & Development
Daniele de Almeida Soares-Marangoni, Natália Matos Tedesco, Andressa Lagoa Nascimento, Priscila Rimoli De Almeida, Caroline Neder Dos Santos Pereira
OBJECTIVE: We described the general movements (GMs) in the fidgety period and the motor performance of two infants who were exposed to Zika virus (ZIKV) during distinct trimesters of gestation. METHODS: Infants were assessed at 4 and 12 months of age. Prechtl's GM assessment and the Alberta Infant Motor Scale were used. RESULTS: In Case 1, the mother presented confirmed ZIKV infection in the 10th week of gestation and the infant was born full-term with brain abnormalities and microcephaly...
February 16, 2018: Developmental Neurorehabilitation
Péricles Alves Nogueira, Regina Maura Cabral de Melo Abrahão, Vera Maria Neder Galesi, Rossana Verónica Mendoza López
OBJECTIVE: Estimate the prevalence of active tuberculosis and latent tuberculosis infection among the staff that is in contact and the staff that is not in contact with prisoners, and investigate factors associated with latent tuberculosis infection in this population. METHODS: Observational cross-sectional study, conducted from 2012 to 2015, in employees of different prison units in the municipality of Franco da Rocha, SP. It consisted of the application of a questionnaire, application and reading of the tuberculin test, sputum smear microscopy, sputum culture, and radiological examination...
February 5, 2018: Revista de Saúde Pública
Daniela M Bravo, Ana Cristina Gimenes, Beatriz C Amorim, Maria Clara Alencar, Danilo C Berton, Denis E O'Donnell, Luiz E Nery, J Alberto Neder
Interval exercise delays critical mechanical-ventilatory constraints with positive consequences on Dyspnoea and exercise tolerance in COPD. We hypothesized that those advantages of interval exercise would be partially off-set in patients showing excessive ventilation (V˙E) to metabolic demand (V˙CO2 ). Sixteen men (FEV1  = 42.3 ± 8.9%) performed, on different days, 30 s and 60 s bouts at 100% peak (on) interspersed by moderate exercise at 40% (off). Nine patients did not sustain exercise for 30 min irrespective of on duration...
April 2018: Respiratory Physiology & Neurobiology
Robert F Bentley, Joshua H Jones, Daniel M Hirai, Joel T Zelt, Matthew D Giles, James P Raleigh, Joe Quadrilatero, Brendon J Gurd, J Alberto Neder, Michael E Tschakovsky
Considerable interindividual differences in the Q˙-V˙O2 relationship during exercise have been documented but implications for submaximal exercise tolerance have not been considered. We tested the hypothesis that these interindividual differences were associated with differences in exercising muscle deoxygenation and ratings of perceived exertion (RPE) across a range of submaximal exercise intensities. A total of 31 (21 ± 3 years) healthy recreationally active males performed an incremental exercise test to exhaustion 24 h following a resting muscle biopsy...
January 2018: Physiological Reports
Ana Beatriz Bozzini, Luciana Neder, Clovis A Silva, Gilda Porta
OBJECTIVE: The objective of this study was to evaluate the health-related quality of life in children and adolescents with autoimmune hepatitis. METHODS: A cross-sectional assessment with the Pediatric Quality of Life Inventory 4.0 (PedsQL 4.0) was completed for 80 patients with autoimmune hepatitis and 45 healthy controls. Demographic data, prednisone dose, disease remission state, disease severity, and abdominal pain were also evaluated. RESULTS: Based on the child self-reports, physical, emotional, school, and total scores were significantly lower in autoimmune hepatitis patients when compared with controls (p<0...
January 10, 2018: Jornal de Pediatria
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