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https://www.readbyqxmd.com/read/28326005/bioactivity-of-food-peptides-biological-response-of-rats-to-bovine-milk-whey-peptides-following-acute-exercise
#1
Carolina Soares Moura, Pablo Christiano Barboza Lollo, Priscila Neder Morato, Eder Muller Risso, Jaime Amaya-Farfan
Background: Several physiologically beneficial effects of consuming a whey protein hydrolysate (WPH) have been attributed to the greater availability of bioactive peptides. Aims: The aim was to investigate the effect of four branched-chain amino acid- (BCAA-)containing dipeptides, present in WPH, on immune modulation, stimulation of HSP expression, muscle protein synthesis, glycogen content, satiety signals and the impact of these peptides on the plasma free amino acid profiles. Methods: The animals were divided in groups: control (rest, without gavage), vehicle (water), L-isoleucyl-L-leucine (lle-Leu), L-leucyl-L-isoleucine (Leu-lle), L-valyl-Lleucine (Val-Leu), L-leucyl-L-valine (Leu-Val) and WPH...
2017: Food & Nutrition Research
https://www.readbyqxmd.com/read/28302031/hif1a-is-overexpressed-in-medulloblastoma-and-its-inhibition-reduces-proliferation-and-increases-epas1-and-atg16l1-methylation
#2
Gustavo Alencastro Veiga Cruzeiro, Maristella Bergamo Dos Reis, Vanessa Silva Silveira, Régia Caroline Peixoto Lira, Carlos Gilberto Carlotti, Luciano Neder, Ricardo Santos Oliveira, José Andres Yunes, Silvia Regina Brandalise, Simone Aguiar, Agda Karina Eterovic, Luiz Gonzaga Tone, Carlos Alberto Scrideli, Elvis Terci Valera
BACKGROUND: Genetic and epigenetic modifications are closely related to tumor initiation and progression and can provide guidance for understanding tumor functioning, potentially leading to the discovery of new therapies. Studies have associated hypoxia-related genes to tumor progression and chemo/radioresistance in brain tumors. Information on the expression profile of hypoxia-related genes in pediatric medulloblastoma, although scarce, may reveal relevant information that could support treatment decisions...
March 15, 2017: Current Cancer Drug Targets
https://www.readbyqxmd.com/read/28296432/improving-clinical-alarm-management-guidance-and-strategies
#3
Pam Cosper, Mary Zellinger, Allen Enebo, Samantha Jacques, Lynn Razzano, Marilyn Neder Flack
This article focuses on the type of problems that lead to false or nonactionable clinical alarms and the type of data that can help identify which of these alarms are most prevalent in specific units in healthcare facilities. The process of identifying necessary data is first described, as this activity will drive later choices on capturing data. This article also discusses how to use the data collected in alarm reports to help determine which alarms should be targeted first for improved management in a pilot environment...
March 2017: Biomedical Instrumentation & Technology
https://www.readbyqxmd.com/read/28283778/plk1-associated-micrornas-are-correlated-with-pediatric-medulloblastoma-prognosis
#4
Julia Alejandra Pezuk, María Sol Brassesco, Ricardo Santos de Oliveira, Hélio Rubens Machado, Luciano Neder, Carlos Alberto Scrideli, Luiz Gonzaga Tone
PURPOSE: Medulloblastoma (MB) is the most common malignant tumor of the central nervous system (CNS) in children. Despite its relative good survival rates, treatment can cause long time sequels and may impair patients' lifespan and quality, making the search for new treatment options still necessary. Polo like kinases (PLKs) constitute a five-member serine/threonine kinases family (PLK 1-5) that regulates different stages during cell cycle. Abnormal PLKs expression has been observed in several cancer types, including MB...
March 10, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28275353/advances-in-the-evaluation-of-respiratory-pathophysiology-during-exercise-in-chronic-lung-diseases
#5
REVIEW
Denis E O'Donnell, Amany F Elbehairy, Danilo C Berton, Nicolle J Domnik, J Alberto Neder
Dyspnea and exercise limitation are among the most common symptoms experienced by patients with various chronic lung diseases and are linked to poor quality of life. Our understanding of the source and nature of perceived respiratory discomfort and exercise intolerance in chronic lung diseases has increased substantially in recent years. These new mechanistic insights are the primary focus of the current review. Cardiopulmonary exercise testing (CPET) provides a unique opportunity to objectively evaluate the ability of the respiratory system to respond to imposed incremental physiological stress...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28275174/physiological-and-clinical-relevance-of-exercise-ventilatory-efficiency-in-copd
#6
REVIEW
J Alberto Neder, Danilo C Berton, Flavio F Arbex, Maria Clara Alencar, Alcides Rocha, Priscila A Sperandio, Paolo Palange, Denis E O'Donnell
Exercise ventilation (V'E) relative to carbon dioxide output (V'CO2 ) is particularly relevant to patients limited by the respiratory system, e.g. those with chronic obstructive pulmonary disease (COPD). High V'E-V'CO2 (poor ventilatory efficiency) has been found to be a key physiological abnormality in symptomatic patients with largely preserved forced expiratory volume in 1 s (FEV1). Establishing an association between high V'E-V'CO2 and exertional dyspnoea in mild COPD provides evidence that exercise intolerance is not a mere consequence of detraining...
March 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28259231/zika-virus-meningoencephalitis-in-an-immunocompromised-patient
#7
Pedro V Schwartzmann, Leandra N Z Ramalho, Luciano Neder, Fernando C Vilar, Sílvia M Ayub-Ferreira, Marília F Romeiro, Osvaldo M Takayanagui, Antonio C Dos Santos, André Schmidt, Luiz T M Figueiredo, Ross Arena, Marcus V Simões
The World Health Organization considers the Zika virus (ZIKV) outbreak in the Americas a global public health emergency. The neurologic complications due to ZIKV infection comprise microcephaly, meningoencephalitis, and Guillain-Barré syndrome. We describe a fatal case of an adult patient receiving an immunosuppressive regimen following heart transplant. The patient was admitted with acute neurologic impairment and experienced progressive hemodynamic instability and mental deterioration that finally culminated in death...
March 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/28255088/oral-n-acetylcysteine-and-exercise-tolerance-in-mild-chronic-obstructive-pulmonary-disease
#8
Daniel M Hirai, Joshua H Jones, Joel T Zelt, Marianne L da Silva, Robert F Bentley, Brittany Ann Edgett, Brendon James Gurd, Michael E Tschakovsky, Denis E O'Donnell, J Alberto Neder
Heightened oxidative stress is implicated in the progressive impairment of skeletal muscle vascular and mitochondrial function in chronic obstructive pulmonary disease (COPD). Whether accumulation of reactive oxygen species contribute to exercise intolerance in the early stages of COPD is unknown. We examined the effects of oral antioxidant treatment with N-acetylcysteine (NAC) on respiratory, cardiovascular and locomotor muscle function and exercise tolerance in patients with mild COPD. Thirteen patients with forced expiratory volume in one second and forced vital capacity ratio (FEV1/FVC) < lower limit of normal (LLN) and FEV1 ≥ LLN were enrolled in a double-blind, randomized crossover study to receive NAC (1800 mg/day) or placebo for 4 days...
March 2, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28243170/elbow-ulnar-neuropathy-treatment-by-anterior-transposition-of-the-ulnar-nerve
#9
Antonio Tufi Neder, Regina de Azevedo Alves, Arlindo Gomes Pardini, Marcelo Riberto, Milton Mazer
OBJECTIVES: Retrospective clinical evaluation of 31 patients who underwent ulnar nerve decompression at the elbow and subcutaneous anterior transposition. METHODS: From January 2000 to December 2013, 71 patients underwent subcutaneous anterior transposition of the ulnar nerve. Thirty-one patients returned for evaluation. The mean follow-up period was 60 months. Patients were evaluated for the degree of satisfaction after surgery, paresthesia, pain, Tinel sign, Froment test and sensitivity test by esthesiometer, muscle strength of the intrinsic muscles and deep flexor of the fifth digit, visual analogic pain scale (VAS) and were subjected to the QuickDash questionnaire...
July 2016: Acta Ortopedica Brasileira
https://www.readbyqxmd.com/read/27997255/emphysema-on-thoracic-ct-and-exercise-ventilatory-inefficiency-in-mild-to-moderate-copd
#10
Joshua H Jones, Joel T Zelt, Daniel M Hirai, Camilla V Diniz, Aida Zaza, Denis E O'Donnell, J Alberto Neder
There is growing evidence that emphysema on thoracic computed tomography (CT) is associated with poor exercise tolerance in COPD patients with only mild-to-moderate airflow obstruction. We hypothesized that an excessive ventilatory response to exercise (ventilatory inefficiency) would underlie these abnormalities. In a prospective study, 19 patients (FEV1 = 82 ± 13%, 12 Global Initiative for Chronic Obstructive Lung Disease (GOLD) stage 1) and 26 controls underwent an incremental exercise test. Ventilatory inefficiency was assessed by the ventilation ([Formula: see text]E)/CO2 output ([Formula: see text]CO2) nadir...
December 20, 2016: COPD
https://www.readbyqxmd.com/read/27940276/maximal-inspiratory-pressure-does-the-choice-of-reference-values-actually-matter
#11
Antenor Rodrigues, Marianne L Da Silva, Danilo C Berton, Gerson Cipriano, Fabio Pitta, Denis E O'Donnell, J Alberto Neder
BACKGROUND: Single-point measurements of maximal inspiratory pressure (MIP) are frequently used to suggest muscle weakness in clinical practice. Although there is a large variability in "mean" predicted MIP depending on the chosen reference values, it remains unclear whether those discrepancies actually impact on the prevalence of weakness, i.e., MIP below the lower limit of normal. METHODS: 1729 subjects (50.1% males, aged 20 to 94) who underwent MIP measurements in a clinical laboratory comprised the study group...
December 8, 2016: Chest
https://www.readbyqxmd.com/read/27903672/-exertional-dyspnoea-in-copd-the-clinical-utility-of-cardiopulmonary-exercise-testing-denis-e-o-donnell-amany-f-elbehairy-azmy-faisal-katherine-a-webb-j-alberto-neder-and-donald-a-mahler-eur-respir-rev-2016-25-333-347
#12
(no author information available yet)
No abstract text is available yet for this article.
December 2016: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/27900530/erratum-to-the-dna-methyltransferase-inhibitor-zebularine-exerts-antitumor-effects-and-reveals-batf2-as-a-poor-prognostic-marker-for-childhood-medulloblastoma
#13
Augusto Faria Andrade, Kleiton Silva Borges, Veridiana Kiill Suazo, Lenisa Geron, Carolina Alves Pereira Corrêa, Angel Mauricio Castro-Gamero, Elton José Rosas de Vasconcelos, Ricardo Santos de Oliveira, Luciano Neder, José Andres Yunes, Simone Dos Santos Aguiar, Carlos Alberto Scrideli, Luiz Gonzaga Tone
No abstract text is available yet for this article.
November 29, 2016: Investigational New Drugs
https://www.readbyqxmd.com/read/27888114/limonene-reduces-hyperalgesia-induced-by-gp120-and-cytokines-by-modulation-of-il-1-%C3%AE-and-protein-expression-in-spinal-cord-of-mice
#14
Ana Claudia Piccinelli, Priscila Neder Morato, Marcelo Dos Santos Barbosa, Julio Croda, Jared Sampson, Xiangpeng Kong, Elisabete Castelon Konkiewitza, Edward B Ziff, Jaime Amaya-Farfan, Cândida Aparecida Leite Kassuya
AIMS: We have investigated the antihyperalgesic effects of limonene in mice that received intrathecal injection of gp120. MAIN METHODS: Male Swiss mice received gp120, IL-1β or TNF-α intrathecally or sterile saline as a control. A mechanicalsensitivity test was performed at 2 and 3h after the injection. Spinal cord and blood samples were isolated for protein quantification. KEY FINDINGS: Intrathecal administration of gp120 increased mechanical sensitivity measured with an electronic Von Frey apparatus, at 2 and 3h after the injections...
November 22, 2016: Life Sciences
https://www.readbyqxmd.com/read/27832235/influence-of-heart-failure-on-resting-lung-volumes-in-patients-with-copd
#15
Aline Soares de Souza, Priscila Abreu Sperandio, Adriana Mazzuco, Maria Clara Alencar, Flávio Ferlin Arbex, Mayron Faria de Oliveira, Denis Eunan O'Donnell, José Alberto Neder
Objective: To evaluate the influence of chronic heart failure (CHF) on resting lung volumes in patients with COPD, i.e., inspiratory fraction-inspiratory capacity (IC)/TLC-and relative inspiratory reserve-[1 - (end-inspiratory lung volume/TLC)]. Methods: This was a prospective study involving 56 patients with COPD-24 (23 males/1 female) with COPD+CHF and 32 (28 males/4 females) with COPD only-who, after careful clinical stabilization, underwent spirometry (with forced and slow maneuvers) and whole-body plethysmography...
July 2016: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
https://www.readbyqxmd.com/read/27824399/p27-cdkn1b-translational-regulators-in-pituitary-tumorigenesis
#16
C S Martins, R C Camargo, F P Saggioro, L Neder, H R Machado, A C Moreira, M de Castro
In pituitary tumors, P27(CDKN1B) is underexpressed. We aimed to clarify whether translational regulation underlies this phenomenon. This study evaluated the expression of P27/CDKN1B, its targets (CCNE1, CDK2) and translational regulators (DKC1, RPS13, miR221, miR222) and screened for DKC1 variants in sporadic pituitary adenomas. Samples were obtained during transsphenoidal surgery from 48 patients with pituitary adenomas: 10 ACTH-, 17 GH-secreting, and 21 nonfunctioning (NFPA). The control group comprised 7 normal pituitaries (NP) obtained during autopsies...
December 2016: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/27817818/clinical-usefulness-of-end-tidal-co2-profiles-during-incremental-exercise-in-patients-with-chronic-thromboembolic-pulmonary-hypertension
#17
R P Ramos, E V M Ferreira, F M Valois, A Cepeda, C M S Messina, R K Oliveira, A T V Araújo, C A Teles, J A Neder, L E Nery, J S Ota-Arakaki
INTRODUCTION: Great ventilation to carbon dioxide output (ΔV˙E/ΔV˙CO2) and reduced end-tidal partial pressures for CO2 (PetCO2) during incremental exercise are hallmarks of chronic thromboembolic pulmonary hypertension (CTEPH) and idiopathic pulmonary arterial hypertension (IPAH). However, CTEPH is more likely to involve proximal arteries, which may lead to poorer right ventricle-pulmonary vascular coupling and worse gas exchange abnormalities. Therefore, abnormal PetCO2 profiles during exercise may be more prominent in patients with CTEPH and could be helpful to indicate disease severity...
November 2016: Respiratory Medicine
https://www.readbyqxmd.com/read/27809198/celebrating-100-years-of-the-debye-scattering-equation
#18
Paolo Scardi, Simon J L Billinge, Reinhard Neder, Antonio Cervellino
One hundred years of the Debye scattering equation are celebrated with a series of articles arising from the DSE 2015 conference.
November 1, 2016: Acta Crystallographica. Section A, Foundations and Advances
https://www.readbyqxmd.com/read/27785591/the-dna-methyltransferase-inhibitor-zebularine-exerts-antitumor-effects-and-reveals-batf2-as-a-poor-prognostic-marker-for-childhood-medulloblastoma
#19
Augusto Faria Andrade, Kleiton Silva Borges, Veridiana Kiill Suazo, Lenisa Geron, Carolina Alves Pereira Corrêa, Angel Mauricio Castro-Gamero, Elton José Rosas de Vasconcelos, Ricardo Santos de Oliveira, Luciano Neder, José Andres Yunes, Simone Dos Santos Aguiar, Carlos Alberto Scrideli, Luiz Gonzaga Tone
Medulloblastoma (MB) is the most common solid tumor among pediatric patients and corresponds to 20 % of all pediatric intracranial tumors in this age group. Its treatment currently involves significant side effects. Epigenetic changes such as DNA methylation may contribute to its development and progression. DNA methyltransferase (DNMT) inhibitors have shown promising anticancer effects. The agent Zebularine acts as an inhibitor of DNA methylation and shows low toxicity and high efficacy, being a promising adjuvant agent for anti-cancer chemotherapy...
October 26, 2016: Investigational New Drugs
https://www.readbyqxmd.com/read/27784687/dietary-nitrate-supplementation-and-exercise-tolerance-in-patients-with-heart-failure-with-reduced-ejection-fraction
#20
Daniel M Hirai, Joel T Zelt, Joshua H Jones, Luiza G Castanhas, Robert F Bentley, Wendy Earle, Patti Staples, Michael E Tschakovsky, John McCans, Denis E O'Donnell, J Alberto Neder
Endothelial dysfunction and reduced nitric oxide (NO) signaling are key abnormalities leading to skeletal muscle oxygen delivery-utilization mismatch and poor physical capacity in patients with heart failure with reduced ejection fraction (HFrEF). Oral inorganic nitrate supplementation provides an exogenous source of NO that may enhance locomotor muscle function and oxygenation with consequent improvement in exercise tolerance in HFrEF. Thirteen patients (left ventricular ejection fraction ≤40%) were enrolled in a double-blind, randomized crossover study to receive concentrated nitrate-rich (nitrate) or nitrate-depleted (placebo) beetroot juice for 9 days...
January 1, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
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