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Denis E O'Donnell, J Alberto Neder, Ingrid Harle, Onofre Moran-Mendoza
Idiopathic pulmonary fibrosis (IPF) is one of the most common forms of interstitial lung disease, with a median survival time of two to five years. Most patients with IPF experience chronic breathlessness, which is closely linked to poor perceived quality of life and significant restriction of daily activities; therefore, effective management of this distressing symptom is a major goal of patient care. Areas covered: This report summarizes the physiology of IPF during rest and exercise, outlines current concepts of the mechanisms of breathlessness, and provides a physiological rationale for optimal management of individual patient...
October 21, 2016: Expert Review of Respiratory Medicine
Maria B Mesch, Kilian Bärwinkel, Yaşar Krysiak, Charlotte Martineau, Francis Taulelle, Reinhard B Neder, Ute Kolb, Jürgen Senker
Poly(triazine imide) with incorporated lithium chloride has recently attracted substantial attention due to its photocatalytic activity for water splitting. However, an apparent H/Li disorder prevents the delineation of structure-property relationships, for example, with respect to band-gap tuning. Herein, we show that through a combination of one- and two-dimensional, multinuclear solid-state NMR spectroscopy, chemical modelling, automated electron diffraction tomography, and an analysis based on X-ray pair distribution functions, it is finally possible to resolve the H/Li substructure...
October 13, 2016: Chemistry: a European Journal
Alcides Rocha, Flavio F Arbex, Maria Clara N Alencar, Priscila A Sperandio, Daniel M Hirai, Danilo C Berton, Denis E O'Donnell, J Alberto Neder
BACKGROUND: Exercise oscillatory ventilation (EOV) is associated with poor ventilatory efficiency and higher operating lung volumes in heart failure. These abnormalities may be particularly deleterious to dyspnea and exercise tolerance in mechanically-limited patients, e.g. those with coexistent COPD. METHODS: Ventilatory, gas exchange and sensory responses to incremental exercise were contrasted in 68 heart failure-COPD patients (12 EOV+). EOV was established by standard criteria...
September 24, 2016: International Journal of Cardiology
Rafaela de Barros E Lima Bueno, Anelisa Ramão, Daniel Guariz Pinheiro, Cleidson Padua Alves, Vinicius Kannen, Achim A Jungbluth, Luiza Ferreira de Araújo, Bruna Rodrigues Muys, Aline Simoneti Fonseca, Jessica Rodrigues Plaça, Rodrigo Alexandre Panepucci, Luciano Neder, Fabiano P Saggioro, Rui Celso M Mamede, David Livingstone Alves Figueiredo, Wilson Araújo Silva
Laryngeal squamous cell carcinoma (LSCC) is a very aggressive cancer, considered to be a subtype of the head and neck squamous cell carcinoma (HNSCC). Despite significant advances in the understanding and treatment of cancer, prognosis of patients with LSCC has not improved recently. In the present study, we sought to understand better the genetic mechanisms underlying LSCC development. Thirty-two tumor samples were collected from patients undergoing surgical resection of LSCC. The samples were submitted to whole-genome cDNA microarray analysis aiming to identify genetic targets in LSCC...
September 22, 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
Antenor Rodrigues, Marianna Di Martino, Aline G Nellessen, Nidia A Hernandes, J Alberto Neder, Fabio Pitta
BACKGROUND: It is not yet completely known whether the 6MWT can be used to prescribe high-intensity exercise for patients with COPD. OBJECTIVE: To evaluate the ability of the six-minute walk test (6MWT) to prescribe high-intensity exercise for patients with chronic obstructive pulmonary disease (COPD). METHODS: Lung function, maximal inspiratory strength, symptoms and exercise capacity were evaluated in patients with COPD (n = 27) before and after a 12-week high-intensity exercise program...
September 14, 2016: Heart & Lung: the Journal of Critical Care
Denis E O'Donnell, Amany F Elbehairy, Azmy Faisal, Katherine A Webb, J Alberto Neder, Donald A Mahler
Activity-related dyspnoea is often the most distressing symptom experienced by patients with chronic obstructive pulmonary disease (COPD) and can persist despite comprehensive medical management. It is now clear that dyspnoea during physical activity occurs across the spectrum of disease severity, even in those with mild airway obstruction. Our understanding of the nature and source of dyspnoea is incomplete, but current aetiological concepts emphasise the importance of increased central neural drive to breathe in the setting of a reduced ability of the respiratory system to appropriately respond...
September 2016: European Respiratory Review: An Official Journal of the European Respiratory Society
Maria Claudia Nogueira Zerbini, Mirian Nacagami Sotto, Fernando Peixoto Ferraz de Campos, Andre Neder Ramires Abdo, Juliana Pereira, José Antônio Sanches, Jade Cury Martins
First described in 1985, intermediate cell histiocytosis is a rare disorder of the cutaneous dendritic cell group with a varied clinical presentation and evolution. The pathologic substrate is constituted by the proliferation of indeterminate cells (ICs) that are immunophenotypically characterized by the positivity of CD1a, CD68, and faint/focal S100, plus the negativity for CD207 (langerin). The authors present the case of a healthy elderly woman who presented generalized dome-shaped reddish cutaneous nodules over her trunk, neck, face, and extremities over a period of 18 months...
April 2016: Autopsy & case reports
David Neder-Suárez, Carlos A Amaya-Guerra, Armando Quintero-Ramos, Esther Pérez-Carrillo, María G de J Alanís-Guzmán, Juan G Báez-González, Carlos L García-Díaz, María A Núñez-González, Daniel Lardizábal-Gutiérrez, Jorge A Jiménez-Castro
Effects of extrusion cooking and low-temperature storage on the physicochemical changes and resistant starch (RS) content in cornstarch were evaluated. The cornstarch was conditioned at 20%-40% moisture contents and extruded in the range 90-130 °C and at screw speeds in the range 200-360 rpm. The extrudates were stored at 4 °C for 120 h and then at room temperature. The water absorption, solubility index, RS content, viscoelastic, thermal, and microstructural properties of the extrudates were evaluated before and after storage...
2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Erika Treptow, Mayron F Oliveira, Aline Soares, Roberta P Ramos, Luiz Medina, Rita Lima, Maria Clara Alencar, Eloara Vieira Ferreira, Jaquelina S Ota-Arakaki, Sergio Tufik, Luiz E Nery, Lia Rita Bittencourt, J Alberto Neder
Hypocapnia and endothelial dysfunction might impair microvascular cerebral blood flow (CBFmicr) and cerebrovascular reactivity to CO2 (CVRCO2). Pulmonary arterial hypertension (PAH) is characteristically associated with chronic alveolar hyperventilation and microvascular endothelial dysfunction. We therefore determined CBFmicr (pre-frontal blood flow index (BFI) by the indocyanine green-near infrared spectroscopy methodology) during hypocapnia and hypercapnia in 25 PAH patients and 10 gender- and age-matched controls...
November 2016: Respiratory Physiology & Neurobiology
Amany F Elbehairy, Jordan A Guenette, Azmy Faisal, Casey E Ciavaglia, Katherine A Webb, Dennis Jensen, Andrew H Ramsook, J Alberto Neder, Denis E O'Donnell
Dyspnoea and activity limitation can occur in smokers who do not meet spirometric criteria for chronic obstructive pulmonary disease (COPD) but the underlying mechanisms are unknown.Detailed pulmonary function tests and sensory-mechanical relationships during incremental exercise with respiratory pressure measurements and diaphragmatic electromyography (EMGdi) were compared in 20 smokers without spirometric COPD and 20 age-matched healthy controls.Smokers (mean±sd post-bronchodilator forced expiratory volume in 1 s (FEV1)/forced vital capacity 75±4%, mean±sd FEV1 104±14% predicted) had greater activity-related dyspnoea, poorer health status and lower physical activity than controls...
September 2016: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
Diego de Paiva Azevedo, Wladimir Musetti Medeiros, Flávia Fernandes Manfredi de Freitas, Cesar Ferreira Amorim, Ana Cristina Oliveira Gimenes, Jose Alberto Neder, Luciana Dias Chiavegato
PURPOSE: It was hypothesized that patients with chronic obstructive pulmonary disease (COPD) would exhibit a slow muscle deoxygenation (HHb) recovery time when compared with sedentary controls. METHODS: Neuromuscular electrical stimulation (NMES 40 and 50 mA, 50 Hz, 400 µs) was employed to induce isometric contraction of the quadriceps. Microvascular oxygen extraction (µO2EF) and HHb were estimated by near-infrared spectroscopy (NIRS). Recovery kinetic was characterized by measuring the time constant Tau (HHb-τ)...
October 2016: European Journal of Applied Physiology
J Alberto Neder, Denis E O'Donnell
There has been a surge of interest in endoscopic lung volume reduction (ELVR) strategies for advanced COPD. Valve implants, coil implants, biological LVR (BioLVR), bronchial thermal vapour ablation, and airway stents are used to induce lung deflation with the ultimate goal of improving respiratory mechanics and chronic dyspnea. Patients presenting with severe air trapping (e.g., inspiratory capacity/total lung capacity (TLC) < 25%, residual volume > 225% predicted) and thoracic hyperinflation (TLC > 150% predicted) have the greatest potential to derive benefit from ELVR procedures...
2016: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
J Alberto Neder, Daniel M Hirai, Joshua H Jones, Joel T Zelt, Danilo C Berton, Denis E O'Donnell
A 56-year-old white woman was referred to the pulmonary clinic for evaluation of unexplained shortness of breath. She enjoyed good health until 3 months prior to this visit when she reported experiencing recurrent episodes of shortness of breath and oppressive retrosternal chest discomfort with radiation to the neck. Episodes lasting 5 to 10 min often occurred at rest and were inconsistently related to physical activity. These symptoms became progressively worse and were often associated with light-headedness and presyncope...
July 2016: Chest
José Eduardo Peixoto-Santos, Orfa Yineth Galvis-Alonso, Tonicarlo Rodrigues Velasco, Ludmyla Kandratavicius, João Alberto Assirati, Carlos Gilberto Carlotti, Renata Caldo Scandiuzzi, Luciano Neder Serafini, João Pereira Leite
[This corrects the article DOI: 10.1371/journal.pone.0044709.].
2016: PloS One
Sjaak Pouwels, Marc P Buise, Frank W J M Smeenk, Joep A W Teijink, Simon W Nienhuijs
STUDY OBJECTIVE: Obesity has detrimental effects on general health and respiratory function. This study aimed to evaluate respiratory muscle strength in the morbidly obese population, before and after bariatric surgery, and to compare these estimates with the predictive values using different mathematical equations available. DESIGN: Prospective cohort study. SETTING: Outpatient clinic for the treatment of obesity. PATIENTS: Patients scheduled for elective bariatric surgery...
August 2016: Journal of Clinical Anesthesia
Patricia Puccetti Pires, Marcia Yoshie Kanegae, Jairo Rays, Marcos Catania, Fabiana Roberto Lima, Thiago Rodrigo Noronha, Andre Neder Ramires Abdo, Juliana Pereira
Diffuse large B-cell lymphoma (DLBCL) is the most common non-Hodgkin lymphoma comprising a heterogeneous group of disorders with variable histological and clinical behavior. Although other lymphomas may present in the leukemic phase more frequently, this appearance is unusually observed among DLBCL cases. Diagnosing lymphoma is not always easy, and the patient's clinical status quite often may hamper invasive procedures for diagnosis pushing the clinician to look for alternatives to reach the nearest possible accurate diagnosis...
January 2016: Autopsy & case reports
Antonio Tufi Neder, Eduardo Traldi Franceschini, Arlindo Gomes Pardini, Marcelo Riberto, Nilton Mazzer
OBJECTIVE: To evaluate the outcome of olecranon bone graft and compression screw for the treatment of nonunion of the Lichtman type I scaphoid. METHOD: We evaluated 15 patients of 32 who underwent surgical treatment for nonunion of the Lichtman type I scaphoid with olecranon bone graft and screw compression. RESULTS: We obtained 100% consolidation in our sample. The mean flexion of the wrist on the affected side was 68° and 75° on the non-affected side...
May 2016: Acta Ortopedica Brasileira
Régia Caroline Peixoto Lira, Paola Fernanda Fedatto, David Santos Marco Antonio, Letícia Ferro Leal, Carlos Eduardo Martinelli, Margaret de Castro, Silvio Tucci, Luciano Neder, Leandra Ramalho, Ana Luiza Seidinger, Izilda Cardinalli, Maria José Mastellaro, José Andres Yunes, Silvia Regina Brandalise, Luiz Gonzaga Tone, Sonir Roberto Rauber Antonini, Carlos Alberto Scrideli
Deregulation of the IGF system observed in human tumors indicates a role in malignant cell transformation and in tumor cell proliferation. Although overexpression of the IGF2 and IGF1R genes was described in adrenocortical tumors (ACTs), few studies reported their profiles in pediatric ACTs. In this study, the IGF2 and IGF1R expression was evaluated by RT-qPCR according to the patient's clinical/pathological features in 60 pediatric ACT samples, and IGF1R protein was investigated in 45 samples by immunohistochemistry (IHC)...
June 2015: Endocrine-related Cancer
Flavio F Arbex, Maria Clara Alencar, Aline Souza, Adriana Mazzuco, Priscila A Sperandio, Alcides Rocha, Daniel M Hirai, Frederico Mancuso, Danilo C Berton, Audrey Borghi-Silva, Dirceu R Almeida, Denis E O'Donnell, J Alberto Neder
Systolic heart failure is a common and disabling co-morbidity of chronic obstructive pulmonary disease (COPD) which may increase exercise ventilation due to heightened neural drive and/or impaired pulmonary gas exchange efficiency. The influence of heart failure on exercise ventilation, however, remains poorly characterized in COPD. In a prospective study, 98 patients with moderate to very severe COPD [41 with coexisting heart failure; 'overlap' (left ventricular ejection fraction < 50%)] underwent an incremental cardiopulmonary exercise test (CPET)...
May 12, 2016: COPD
Denis E O'Donnell, Katherine A Webb, Ingrid Harle, J Alberto Neder
INTRODUCTION: Activity-related breathlessness is often the dominant symptom in patients with chronic obstructive pulmonary disease (COPD) and usually persists despite optimal medical therapy. Currently, our inability to meaningfully alter the pathophysiology of the underlying disease means that we must focus our attention on relieving this distressing symptom so as to improve exercise tolerance and quality of life. AREAS COVERED: The current review examines the neurobiology of breathlessness and constructs a solid physiological rationale for amelioration of this distressing symptom...
July 2016: Expert Review of Respiratory Medicine
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