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https://www.readbyqxmd.com/read/29236891/high-expression-of-xiap-and-bcl-2-may-inhibit-programmed-cell-death-in-glioblastomas
#1
Daniela Pretti da Cunha Tirapelli, Isis Lacrose Lustosa, Sarah Bomfim Menezes, Indira Maynart Franco, Andressa Romualdo Rodrigues, Fernanda Maris Peria, Alexandre Magno da Nóbrega Marinho, Luciano Neder Serafini, Carlos Gilberto Carlotti, Luís Fernando Tirapelli
Glioblastoma (GBM) is the most malignant glioma and represents 29% of all brain tumors. Tumorigenesis is intimately connected with characteristics acquired in the physiologic pathway of cellular death. OBJECTIVE: In the present study, the expression of anti-apoptotic (XIAP and Bcl-2) and apoptotic (cytochrome C, caspase 9, APAF-1), caspase 3 and the Smac/DIABLO genes related to the apoptosis pathway were evaluated in 30 samples of glioblastoma. METHODS: The gene expression was evaluated in 30 glioblastomas (WHO grade IV) and compared to 10 white matter control samples with real-time PCR...
December 2017: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/29219330/favorable-concurrence-of-static-and-dynamic-phenomena-at-the-morphotropic-phase-boundary-of-xbini_-0-5-zr_-0-5-o_-3-1-x-pbtio_-3
#2
K Datta, R B Neder, J Chen, J C Neuefeind, B Mihailova
We reveal that concurrent events of inherent entropy boosting and increased synchronization between A- and B-site cation vibrations of an ABO_{3}-type perovskite structure give rise to a larger piezoelectric response in a ferroelectric system at its morphotropic phase boundary (MPB). It is further evident that the superior piezoelectric properties of xBiNi_{0.5}Zr_{0.5}O_{3}-(1-x)PbTiO_{3} in comparison to xBiNi_{0.5}Ti_{0.5}O_{3}-(1-x)PbTiO_{3} are due to the absolute flattening of the local potentials for all ferroelectrically active cations with a higher spontaneous polarization at the MPB...
November 17, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29192822/unraveling-the-cause-of-severe-exertional-dyspnea-in-a-heavy-smoker
#3
Amany F Elbehairy, Karlo Hockmann, Casey E Ciavaglia, Azmy Faisal, Elizabeth Hill, Katherine A Webb, J Alberto Neder, Denis E O'Donnell
No abstract text is available yet for this article.
December 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29175351/prevalence-associated-factors-outcomes-and-transmission-of-extensively-drug-resistant-tuberculosis-among-multidrug-resistant-tuberculosis-patients-in-s%C3%A3-o-paulo-brazil-a-cross-sectional-study
#4
Juliana Failde Gallo, Juliana Maira Watanabe Pinhata, Vera Simonsen, Vera Maria Neder Galesi, Lucilaine Ferrazoli, Rosângela Siqueira de Oliveira
OBJECTIVES: This study aimed to describe the prevalence, associated factors, treatment outcomes and transmission of extensively drug-resistant tuberculosis (XDR-TB) in the state of São Paulo, Brazil, in the period of 2011 to 2013. METHODS: Drug susceptibility testing to 1st and 2nd line drugs was performed by BACTEC™ MGIT™ 960 and molecular typing, by RFLP-IS6110. Clinical, epidemiological and demographic data were obtained from surveillance information systems for TB...
November 22, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29163685/expression-of-cancer-testis-antigens-mage-a-mage-c1-gage-and-ctag1b-in-benign-and-malignant-thyroid-diseases
#5
Daniel Hardy Melo, Rui Celso Martins Mamede, Luciano Neder, Wilson Araújo Silva, Mateus Camargo Barros-Filho, Luiz Paulo Kowalski, Clóvis Antonio Lopes Pinto, Marco Antônio Zago, David Livingstone Alves Figueiredo, Achim A Jungbluth
Despite considerable advances in the understanding of thyroid gland biology, correctly diagnosing thyroid nodules and treating high-grade thyroid carcinoma remains challenging. Cancer/testis (CT) antigens have emerged as potential diagnostic tools as well as targets of potential cancer vaccinations. In the present study, a total of 117 patients who underwent surgical therapy for thyroid disease were available for analysis. The expression levels of melanoma-associated antigen (MAGE) A, MAGE-C1/CT7, cancer/testis antigen 1B (CTAG1B) and G antigen (GAGE) were analyzed by immunohistochemistry...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/28993264/sensory-mechanical-effects-of-a-dual-bronchodilator-and-its-anticholinergic-component-in-copd
#6
Denis E O'Donnell, Amany F Elbehairy, Azmy Faisal, J Alberto Neder, Katherine A Webb
This randomized, double-blind, crossover study examined the physiological rationale for using a dual long-acting bronchodilator (umeclidinium/vilanterol (UME/VIL)) versus its muscarinic-antagonist component (UME) as treatment for dyspnea and exercise intolerance in moderate COPD. After each 4-week treatment period, subjects performed pulmonary function and symptom-limited constant-work rate cycling tests with diaphragm electromyogram (EMGdi), esophageal (Pes), gastric (Pga) and transdiaphragmatic (Pdi) pressure measurements...
October 7, 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/28977120/a-practical-approach-to-assess-leg-muscle-oxygenation-during-ramp-incremental-cycle-ergometry-in-heart-failure
#7
A C Barroco, P A Sperandio, M Reis, D R Almeida, J A Neder
Heart failure is characterized by the inability of the cardiovascular system to maintain oxygen (O2) delivery (i.e., muscle blood flow in non-hypoxemic patients) to meet O2 demands. The resulting increase in fractional O2 extraction can be non-invasively tracked by deoxygenated hemoglobin concentration (deoxi-Hb) as measured by near-infrared spectroscopy (NIRS). We aimed to establish a simplified approach to extract deoxi-Hb-based indices of impaired muscle O2 delivery during rapidly-incrementing exercise in heart failure...
October 2, 2017: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/28973727/diallel-analysis-for-technological-traits-in-upland-cotton
#8
D R Queiroz, F J C Farias, J J V Cavalcanti, L P Carvalho, D G Neder, L S S Souza, F C Farias, P E Teodoro
Final cotton quality is of great importance, and it depends on intrinsic and extrinsic fiber characteristics. The objective of this study was to estimate general (GCA) and specific (SCA) combining abilities for technological fiber traits among six upland cotton genotypes and their fifteen hybrid combinations, as well as to determine the effective genetic effects in controlling the traits evaluated. In 2015, six cotton genotypes: FM 993, CNPA 04-2080, PSC 355, TAM B 139-17, IAC 26, and TAMCOT-CAMD-E and fifteen hybrid combinations were evaluated at the Experimental Station of Embrapa Algodão, located in Patos, PB, Brazil...
September 21, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28894477/clinical-exercise-testing-basic%C3%A2-principles-and-practice
#9
EDITORIAL
Pierantonio Laveneziana, Susan Ward, J Alberto Neder, Vitalii Poberezhets
Faculty and delegates of an @ERStalk course on clinical exercise testing describe their experiences http://ow.ly/dPwB30dxr8v.
September 2017: Breathe
https://www.readbyqxmd.com/read/28862164/close-packed-structure-dynamics-with-finite-range-interaction-computational-mechanics-with-individual-layer-interaction
#10
Edwin Rodriguez-Horta, Ernesto Estevez-Rams, Raimundo Lora-Serrano, Reinhard Neder
This is the second contribution in a series of papers dealing with dynamical models in equilibrium theories of polytypism. A Hamiltonian introduced by Ahmad & Khan [Phys. Status Solidi B (2000), 218, 425-430] avoids the unphysical assignment of interaction terms to fictitious entities given by spins in the Hägg coding of the stacking arrangement. In this paper an analysis of polytype generation and disorder in close-packed structures is made for such a Hamiltonian. Results are compared with a previous analysis using the Ising model...
September 1, 2017: Acta Crystallographica. Section A, Foundations and Advances
https://www.readbyqxmd.com/read/28812766/modulatory-effects-of-arginine-glutamine-and-branched-chain-amino-acids-on-heat-shock-proteins-immunity-and-antioxidant-response-in-exercised-rats
#11
Carolina Soares Moura, Pablo Christiano Barboza Lollo, Priscila Neder Morato, Eder Muller Risso, Jaime Amaya-Farfan
Heat shock proteins (HSPs) are endogenous proteins whose function is to maintain the cell's tolerance to insult, and glutamine supplementation is known to increase HSP expression during intense exercise. Since few studies have addressed the possibility that supplementation with other amino acids could have similar effects to that of glutamine, our objective was to evaluate the effects of leucine, valine, isoleucine and arginine as potential stimulators of HSPs 25, 60, 70 and 90 in rats subjected to acute exercise as a stressing factor...
September 20, 2017: Food & Function
https://www.readbyqxmd.com/read/28665692/excess-ventilation-in-chronic-obstructive-pulmonary-disease-heart-failure-overlap-implications-for-dyspnea-and-exercise-intolerance
#12
Alcides Rocha, Flavio F Arbex, Priscilla A Sperandio, Aline Souza, Ligia Biazzim, Frederico Mancuso, Danilo C Berton, Bruno Hochhegger, Maria Clara N Alencar, Luiz E Nery, Denis E O'Donnell, J Alberto Neder
RATIONALE: An increased ventilatory response to exertional metabolic demand (high [Formula: see text]e/[Formula: see text]co2 relationship) is a common finding in patients with coexistent chronic obstructive pulmonary disease and heart failure. OBJECTIVES: We aimed to determine the mechanisms underlying high [Formula: see text]e/[Formula: see text]co2 and its impact on operating lung volumes, dyspnea, and exercise tolerance in these patients. METHODS: Twenty-two ex-smokers with combined chronic obstructive pulmonary disease and heart failure with reduced left ventricular ejection fraction undertook, after careful treatment optimization, a progressive cycle exercise test with capillary (c) blood gas collection...
November 15, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28660867/close-packed-structures-with-finite-range-interaction-computational-mechanics-of-layer-pair-interaction
#13
Edwin Rodriguez-Horta, Ernesto Estevez-Rams, Reinhard Neder, Raimundo Lora-Serrano
The stacking problem is approached by computational mechanics, using an Ising next-nearest-neighbour model. Computational mechanics allows one to treat the stacking arrangement as an information processing system in the light of a symbol-generating process. A general method for solving the stochastic matrix of the random Gibbs field is presented and then applied to the problem at hand. The corresponding phase diagram is then discussed in terms of the underlying ℇ-machine, or optimal finite-state machine. The occurrence of higher-order polytypes at the borders of the phase diagram is also analysed...
July 1, 2017: Acta Crystallographica. Section A, Foundations and Advances
https://www.readbyqxmd.com/read/28562788/economic-valuation-of-the-ecosystem-services-provided-by-a-protected-area-in-the-brazilian-cerrado-application-of-the-contingent-valuation-method
#14
F M Resende, G W Fernandes, D C Andrade, H D Néder
Considering that the economic valuation of ecosystem services is a useful approach to support the conservation of natural areas, we aimed to estimate the monetary value of the benefits provided by a protected area in southeast Brazil, the Serra do Cipó National Park. We calculated the visitor's willingness to pay to conserve the ecosystems of the protected area using the contingent valuation method. Located in a region under intense anthropogenic pressure, the Serra do Cipó National Park is mostly composed of rupestrian grassland ecosystems, in addition to other Cerrado physiognomies...
November 2017: Brazilian Journal of Biology, Revista Brasleira de Biologia
https://www.readbyqxmd.com/read/28562736/bariatric-surgery-as-a-treatment-for-pseudotumor-cerebri-case-study-and-narrative-review-of-the-literature
#15
Everton Cazzo, Martinho Antonio Gestic, Murillo Pimentel Utrini, Felipe David Mendonça Chaim, Fábio Henrique Mendonça Chaim, Elaine Cristina Cândido, Luciana Bueno da Silveira Jarolavsky, Ana Maria Neder de Almeida, José Carlos Pareja, Elinton Adami Chaim
CONTEXT: Pseudotumor cerebri occurs when there is an increase in intracranial pressure without an underlying cause, usually leading to loss of vision. It is most commonly observed in obese women of child-bearing age. CASE REPORT: A 46-year-old woman presented at our service with idiopathic intracranial hypertension that had been diagnosed two years earlier, which had led to chronic refractory headache and an estimated 30% loss of visual acuity, associated with bilateral papilledema...
May 29, 2017: São Paulo Medical Journal, Revista Paulista de Medicina
https://www.readbyqxmd.com/read/28558953/are-heart-rate-dynamics-in-the-transition-from-rest-to-submaximal-exercise-related-to-maximal-cardiorespiratory-responses-in-copd
#16
Adriana Mazzuco, Wladimir Musetti Medeiros, Aline Soares de Souza, Maria Clara Noman Alencar, José Alberto Neder, Audrey Borghi-Silva
BACKGROUND: Poor exercise capacity is an important negative prognostic marker in patients with chronic obstructive pulmonary disease (COPD). Heart rate variability (HRV) responses can indicate alterations in cardiac autonomic control. Nevertheless, it remains unclear whether these abnormalities are related to cardiorespiratory responses to exercise in these patients. OBJECTIVE: To evaluate whether HRV at rest and submaximal exercise are related to impaired cardiopulmonary responses to exercise in COPD patients...
July 2017: Brazilian Journal of Physical Therapy
https://www.readbyqxmd.com/read/28548545/mild-chronic-obstructive-pulmonary-disease-why-spirometry-is-not-sufficient
#17
Amany F Elbehairy, Grace Parraga, Katherine A Webb, J Alberto Neder, Denis E O'Donnell
Chronic obstructive pulmonary disease (COPD) - an inflammatory disease of the airways, alveoli and lung microvasculature - is a leading cause of death worldwide. Smokers with milder airway obstruction constitute the majority of patients with this disease. Many studies have shown increased morbidity, activity-related dyspnea, exercise intolerance and mortality in such patients, compared with age-matched healthy populations. Clinical evaluation of symptomatic smokers with ostensibly mild airway obstruction poses a challenge in clinical practice as spirometry can obscure extensive heterogeneous pathophysiological impairment...
July 2017: Expert Review of Respiratory Medicine
https://www.readbyqxmd.com/read/28530858/customizing-alarm-limits-based-on-specific-needs-of-patients
#18
Maria Cvach, Melanie Kitchens, Kevin Smith, Patricia Harris, Marilyn Neder Flack
No abstract text is available yet for this article.
May 2017: Biomedical Instrumentation & Technology
https://www.readbyqxmd.com/read/28492719/does-aortic-valve-repair-in-valve-sparing-aortic-root-reconstruction-compromise-the-longevity-of-the-procedure
#19
Ricardo Ribeiro Dias, José Augusto Duncan, Fabrício José de Souza Dinato, Lucas Lacerda Araújo, Hugo Monteiro Neder Issa, Fábio Fernandes, Charles Mady, Fábio Biscegli Jatene
OBJECTIVES: The effect of performing aortic valve repair in combination with valve-sparing operation on the length of time for which patients are free from reoperation is unclear. The objective of this study was to determine if the performance of aortic valve repair during valve-sparing operation modified the freedom from reoperation time. METHODS: From January 2003 to July 2014, 78 patients with a mean age of 49±15 years underwent valve-sparing operation. Sixty-eight percent of these patients were male...
April 2017: Clinics
https://www.readbyqxmd.com/read/28489139/high-expression-of-anti-apoptotic-genes-in-grade-i-and-ii-meningiomas
#20
Daniela Pretti da Cunha Tirapelli, Sarah Bomfim Menezes, Indira Maynart Franco, Isis Lacrose Lustosa, Andressa Romualdo Rodrigues, Paulo Cézar Novais, Antônio César Mendes Santiago, Fernanda Maris Peria, Luciano Neder Serafini, Alexandre Magno da Nóbrega Marinho, Carlos Gilberto Carlotti, Benedicto Oscar Colli, Luís Fernando Tirapelli
Objective: To evaluate the expression of c-FLIP, XIAP, Bcl-2, caspase 3, 8 and 9, cytochrome c, APAF 1 and Smac/DIABLO genes related to apoptosis pathways. Methods: The gene expression was evaluated in 30 meningiomas (WHO grades I and II) and in 10 normal samples (from arachnoid tissue) through PCR-RT. Results: The results showed higher expression of anti-apoptotic genes in meningiomas when compared to the control group, which had a low expression of pro-apoptotic genes...
April 2017: Arquivos de Neuro-psiquiatria
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