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Yanjiao Zhang, Yushun Gao
BACKGROUND: Lung cancer is a malignancy with high morbidity and mortality rates worldwide. Surgery is the preferred treatment for non-small cell lung cancer. This study aims to investigate the effects of video-assisted thoracoscopic surgery (VATS) lobectomy, VATS segmentectomy, and open thoracotomy on pulmonary function in the early postoperative stage and compare the difference among three groups. METHODS: Pulmonary function data of patients were collected from September 2015 to February 2016 in Department of Thoracic Surgical Oncology, Cancer Hospital Chinese Academy of Medical Sciences...
October 20, 2016: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
Tahreema N Matin, Najib Rahman, Annabel H Nickol, Mitchell Chen, Xiaojun Xu, Neil J Stewart, Tom Doel, Vicente Grau, James M Wild, Fergus V Gleeson
Purpose To compare lobar ventilation and apparent diffusion coefficient (ADC) values obtained with hyperpolarized xenon 129 ((129)Xe) magnetic resonance (MR) imaging to quantitative computed tomography (CT) metrics on a lobar basis and pulmonary function test (PFT) results on a whole-lung basis in patients with chronic obstructive pulmonary disease (COPD). Materials and Methods The study was approved by the National Research Ethics Service Committee; written informed consent was obtained from all patients. Twenty-two patients with COPD (Global Initiative for Chronic Obstructive Lung Disease stage II-IV) underwent hyperpolarized (129)Xe MR imaging at 1...
October 12, 2016: Radiology
Julie Obert, Olivia Freynet, Hilario Nunes, Pierre-Yves Brillet, Makoto Miyara, Robin Dhote, Dominique Valeyre, Jean-Marc Naccache
Interstitial lung disease (ILD) is a common form of extramuscular involvement in patients with polymyositis/dermatomyositis and is associated with poor prognosis. This study was designed to describe the long-term outcome of myositis-associated ILD. This retrospective observational study was conducted in 48 consecutive patients. Two groups defined according to outcome were compared to determine prognostic factors: a "severe" group (vital capacity [VC] < 50 % or carbon monoxide transfer factor [TLCO] < 35 % or death or lung transplantation) and a "nonsevere" group (other patients)...
October 8, 2016: Rheumatology International
Jalpa Kotecha, Ludmila Shulgina, Darren W Sexton, Christopher P Atkins, Andrew M Wilson
BACKGROUND: Declining lung function signifies disease progression in idiopathic pulmonary fibrosis (IPF). Vascular endothelial growth factor (VEGF) concentration is associated with declining lung function in 6 and 12-month studies. Alveolar nitric oxide concentration (CANO) is increased in patients with IPF, however its significance is unclear. This study investigated whether baseline plasma VEGF concentration and CANO are associated with disease progression or mortality in IPF. METHODS: 27 IPF patients were studied (maximum follow-up 65 months)...
September 7, 2016: Journal of Clinical Medicine
B Milani, A Ansaloni, S Sousa-Guimaraes, M Piskunowicz, B Vogt, M Stuber, M Burnier, M Pruijm
OBJECTIVE: The determination of renal tissue oxygenation by BOLD-MRI in chronic kidney disease (CKD) patients has given heterogeneous results, possibly due to the lack of a widely accepted procedure to analyze the R2* maps. We present a new technique for the analysis of renal BOLD-MRI called the twelve-layer concentric objects method (TLCO). We measured its reproducibility and assessed whether differences in the intra-renal distribution of R2* as a measure of oxygenation were detected between CKD patients and controls...
September 2016: Journal of Hypertension
H Sahin, I Naz, Y Varol, N Aksel, F Tuksavul, A Ozsoz
PURPOSE: The aim of this study was to compare the effects of pulmonary rehabilitation (PR) on six-minute walk test (6mWT) between chronic obstructive pulmonary disease (COPD) patients with moderate or severe carbon monoxide diffusion defects. We also evaluated dyspnea sensation, pulmonary functions, blood gases analysis, quality of life parameters and psychological symptoms in both groups before and after pulmonary rehabilitation. METHODS: Patients with COPD underwent a comprehensive 8-week out-patient PR program participated in this study...
April 25, 2016: Revista Portuguesa de Pneumologia
Domokos Bartis, Louise E Crowley, Vijay K D'Souza, Lee Borthwick, Andrew J Fisher, Adam P Croft, Judit E Pongrácz, Richard Thompson, Gerald Langman, Christopher D Buckley, David R Thickett
BACKGROUND: CD248 or Endosialin is a transmembrane molecule expressed in stromal cells binding to extracellular matrix (ECM) components. It has been previously implicated in kidney fibrosis, rheumatoid arthritis as well as in tumour-stromal interactions. This study investigates the role of CD248 in the pathogenesis of fibrotic diseases in Idiopathic Pulmonary Fibrosis (IPF). METHODS: CD248 quantitative immunohistochemistry (IHC) was performed on lung samples from 22 IPF patients and its expression was assayed in cultured pulmonary fibroblasts and epithelial cells...
2016: BMC Pulmonary Medicine
Sylvia Verbanck, Alain Van Muylem, Daniel Schuermans, Ivan Bautmans, Bruce Thompson, Walter Vincken
Monitoring of chronic lung disease requires reference values of lung function indices, including putative markers of small airway function, spanning a wide age range.We measured spirometry, transfer factor of the lung for carbon monoxide (TLCO), static lung volume, resistance and ventilation distribution in a healthy population, studying at least 20 subjects per sex and per decade between the ages of 20 and 80 years.With respect to the Global Lung Function Initiative reference data, our subjects had average z-scores for forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC of -0...
January 2016: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
Sonia Rouatbi, Sonia Mezghenni, Malek Ayachi, Mohamed Benzarti
UNLABELLED: Objectives of this study were to describe sociodemographic characteristics of Tunisian woman smoker and to study her respiratory functional profile. METHODS: all women answered for a questionnaire and benefited of a total physical plethysmography and of a carbon monoxide lung transfer measure (TLCO). RESULTS: 101 smoking women were selected. These women consumed cigarettes (74 %), the snuff "neffa "(10 %) and the water pipe (15 %)...
May 2015: La Tunisie Médicale
Pere Alemany, Jean-Paul Pouget, Enric Canadell
A first-principles density functional theory (DFT) study of [Formula: see text]-(BEDT-TTF)2X molecular conductors with X  =  I3, CsCo(SCN)4 (ambient pressure, 7.5 kbar and 10 kbar), CsZn(SCN)4, TlCo(SCN)4, RbCo(SCN)4 and RbZn(SCN)4 (220 K and 90 K) is reported. It is shown that these salts exhibit three different types of band structure each of them associated with a different physical behavior. In contrast with previous proposals it is found that the key electronic parameter behind the differences in the band structures is the intrastack transfer integral, t c ...
November 25, 2015: Journal of Physics. Condensed Matter: An Institute of Physics Journal
Raoul I Furlano, Pavel Basek, Pascal Müller, Christian Bieli, Christian P Braegger, Jürg Barben, Jürg Hammer, Alexander Moeller, Daniel Trachsel
BACKGROUND: Pulmonary involvement in adult patients with inflammatory bowel disease (IBD) seems more common than previously appreciated. Its prevalence and development over time in pediatric IBD patients are largely unknown. OBJECTIVES: The aim was to study lung function including fraction of exhaled nitric oxide (FeNO) and transfer capacity for carbon monoxide (TLCO) in pediatric IBD patients and to describe the longitudinal development in a subset of patients with lung function abnormalities...
2015: Respiration; International Review of Thoracic Diseases
Marlies Wijsenbeek
PATIENT PRESENTATION AND DIAGNOSTIC WORK-UP: The patient is a 72-year-old man presenting with dyspnoea on exertion. He is a former heavy smoker (40 pack-years) and his father, now deceased, had rheumatoid arthritis (RA). On physical examination he had mild bi-basilar crackles but no finger clubbing. Autoimmune serology was positive for rheumatoid factor (RF: 25 IU/ml). Lung function tests showed normal FVC, a FEV1/FVC ratio of 72% and a TLCO of 49% predicted. Lung CT showed centrilobular and paraseptal emphysema, subpleural fine reticulation and traction bronchiolectasis, with no clear basal predominance (Figure 1)...
2015: Sarcoidosis, Vasculitis, and Diffuse Lung Diseases: Official Journal of WASOG
Venerando Rapisarda, Caterina Ledda, Vincenzo Ricceri, Francesco Arena, Andrea Musumeci, Andrea Marconi, Lucrezia Fago, Massimo Bracci, Lory Santarelli, Margherita Ferrante
Fluoro-edenite is a natural mineral species initially isolated in Biancavilla, Sicily. The fibres are similar in size and morphology to certain amphibolic asbestos fibres, the inhalation of which may cause chronic inflammation and cancer. Occupational asbestos exposure is known to be associated with pleural and lung diseases, including pleural plaques. The aim of this study was to report the pleural and lung parenchymal lesions detected by high-resolution computed tomography (HRCT) in a group of construction workers exposed to fluoro-edenite...
May 2015: Oncology Letters
A Benfante, A Ciresi, M Bellia, F Cannizzaro, V Bellia, C Giordano, N Scichilone
BACKGROUND: Acromegaly is an insidious disorder caused by a pituitary growth hormone (GH)-secreting adenoma resulting in high circulating levels of GH and insulin-like growth factor I (IGF-I). Respiratory disorders are common complications in acromegaly, and can severely impact on quality of life, eventually affecting mortality. OBJECTIVES: The present study aimed to explore structural and functional lung alterations of acromegalic subjects. METHODS: We enrolled 10 consecutive patients (M/F: 5/5) affected by acromegaly...
June 2015: Lung
Pavlos Michailopoulos, Theodoros Kontakiotis, Dionisios Spyratos, Paraskevi Argyropoulou-Pataka, Lazaros Sichletidis
Background: The most commonly used reference equations for the measurement of static lung volumes/capacities and transfer factor of the lung for CO (TLCO) are based on studies around 30-40 years old with significant limitations. Objectives: Our aim was to (1) develop reference equations for static lung volumes and TLCO using the current American Thoracic Society/European Respiratory Society guidelines, and (2) compare the equations derived with those most commonly used. Methods: Healthy Caucasian subjects (234 males and 233 females) aged 18-91 years were recruited...
February 14, 2015: Respiration; International Review of Thoracic Diseases
Richard Pougnet, Laurence Pougnet, David Lucas, Marie Uguen, Anne Henckes, Jean-Dominique Dewitte, Brice Loddé
BACKGROUND: The aim of this study was to assess changes in lung function of professional divers. MATERIALS AND METHODS: This is a review of the literature. Only studies about professional divers were included. All published studies between 01.01.1984 and 07.01.2014 were systematically searched. The search was performed in Medline and Embase databases and in the "Medicina Maritima" journal. The results of pulmonary function tests were extracted from each study. RESULTS: Fifteen articles were found...
2014: International Maritime Health
J Michael B Hughes, Colin D R Borland
No abstract text is available yet for this article.
April 2015: Thorax
J Huang, M Li, Z Tian, E Hsieh, Q Wang, Y Liu, D Xu, Y Hou, J Zhao, X Guo, J Lai, C Hu, N Song, Q Sun, Q Sun, F Zhang, Y Zhao, X Zeng
OBJECTIVES: Pulmonary arterial hypertension (PAH) is associated with significant morbidity and mortality, especially in systemic sclerosis (SSc). Since there was no published study regarding PAH in the Chinese SSc population, we aimed to describe a cohort to provide some data for early diagnosis. METHODS: We evaluated 236 systemic sclerosis patients prospectively registered in the EUSTAR (European League Against Rheumatism Scleroderma Trial and Research Group) database from the Peking Union Medical College Hospital from 2009 to 2012...
November 2014: Clinical and Experimental Rheumatology
E Edvardsen, O H Skjønsberg, I Holme, L Nordsletten, F Borchsenius, S A Anderssen
BACKGROUND: Many patients with lung cancer are deconditioned with poor physical fitness. Lung resection reduces physical fitness further, impairing the patient's ability to function in daily life. METHODS: We conducted a single-blind randomised controlled trial of high-intensity endurance and strength training (60 min, three times a week, 20 weeks), starting 5-7 weeks after surgery. The control group received standard postoperative care. The primary outcome was the change in peak oxygen uptake measured directly during walking until exhaustion...
March 2015: Thorax
V Zarza, S Couraud, A Hassouni, C Prévost, P-J Souquet, G Letanche, Y Hammou, N Girard, C Viart-Ferber, F Mornex
Thoracic radiotherapy is a usual treatment for lung cancer. Early-stages may be treated in stereotactic mode while locally advanced stages are usually treated with conventional radiotherapy mode. Pulmonary function tests show that thoracic irradiation has no impact on lung volume such as forced expiratory volume in one second (FEV1) or forced vital capacity (FCV). However, some studies found that CO (carbon monoxide) diffusing capacity (TLCO) may be altered under thoracic radiotherapy. DLCO alteration is usually symptomatic of either a lesion in the alveolar membrane or a pulmonary capillary alteration...
October 2014: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
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