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https://www.readbyqxmd.com/read/29032138/wedge-pressure-rather-than-left%C3%A2-ventricular-end-diastolic-pressure-predicts-outcome-in-heart-failure-with-preserved-ejection-fraction
#1
Julia Mascherbauer, Caroline Zotter-Tufaro, Franz Duca, Christina Binder, Matthias Koschutnik, Andreas A Kammerlander, Stefan Aschauer, Diana Bonderman
OBJECTIVES: This study sought to compare the prognostic power of left ventricular end-diastolic pressure (LVEDP) and pulmonary arterial wedge pressure (PAWP) in heart failure with preserved ejection fraction (HFpEF). BACKGROUND: It is broadly accepted that direct measurement of LVEDP in HFpEF more robustly reflects left ventricular hemodynamics than PAWP. METHODS: A total of 173 consecutive HFpEF patients were prospectively enrolled. Of these, 152 patients fulfilled registry inclusion criteria...
October 4, 2017: JACC. Heart Failure
https://www.readbyqxmd.com/read/29017478/effectiveness-of-pulmonary-rehabilitation-in-patients-with-interstitial-lung-disease-of-different-etiology-a-multicenter-prospective-study
#2
Roberto Tonelli, Elisabetta Cocconcelli, Barbara Lanini, Isabella Romagnoli, Fabio Florini, Ivana Castaniere, Dario Andrisani, Stefania Cerri, Fabrizio Luppi, Riccardo Fantini, Alessandro Marchioni, Bianca Beghè, Francesco Gigliotti, Enrico M Clini
BACKGROUND: Recent evidences show that Pulmonary Rehabilitation (PR) is effective in patients with Interstitial Lung Disease (ILD). It is still unclear whether disease severity and/or etiology might impact on the reported benefits. We designed this prospective study 1) to confirm the efficacy of rehabilitation in a population of patients with ILDs and 2) to investigate whether baseline exercise capacity, disease severity or ILD etiology might affect outcomes. METHODS: Forty-one patients (IPF 63%, age 66...
October 10, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/28990890/effect-of-reduction-mammoplasty-on-the-pulmonary-function-tests
#3
Erhan Uğurlu, Adem Topkara, Adem Özkan, Ramazan Hakan Özcan, İlknur Can, Göksel Altınışık
Introduction: Bilateral breast reduction surgery is the surgical treatment of bilateral breast hypertrophy. This is one of the most common breast surgery requested by women, and performed by plastic surgeons. The reasons that patients want this surgery are to re-size sagging breasts aesthetically, and to get rid of somatic symptoms such as shoulder, chest, back, and neck pain. We believe that the objective positive effects of breast reduction surgery exist beside aesthetic. In our study, our aim is to elicit positive effects of surgery on lungs, if there are, by making pulmonary function test and carbon monoxide diffusion test before surgery and after 6 months of surgery...
June 2017: Tüberküloz Ve Toraks
https://www.readbyqxmd.com/read/28983773/ipilimumab-and-early-signs-of-pulmonary-toxicity-in-patients-with-metastastic-melanoma-a-prospective-observational-study
#4
Daniel Franzen, Karin Schad, Benedikt Kowalski, Christian F Clarenbach, Roger Stupp, Reinhard Dummer, Malcolm Kohler
Ipilimumab, an immune checkpoint inhibitor, is approved for treatment metastastic melanoma and is a promising agent against other malignancies. There is some preliminary evidence from case reports that ipilimumab treatment may be associated with pulmonary side effects. However, data from prospective studies on ipilimumab-related pulmonary toxicity are still scarce. Serial spirometries and measurements of CO-diffusion capacity (DLCO) in patients with metastatic melanoma before and during treatment with ipilimumab were performed...
October 5, 2017: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/28964798/phenotypic-clusters-predict-outcomes-in-a-longitudinal-interstitial-lung-disease-cohort
#5
Ayodeji Adegunsoye, Justin M Oldham, Jonathan H Chung, Steven M Montner, Cathryn Lee, Leah J Witt, Danielle Stahlbaum, Rene S Bermea, Lena W Chen, Scully Hsu, Aliya N Husain, Imre Noth, Rekha Vij, Mary E Strek, Matthew Churpek
BACKGROUND: The current interstitial lung disease (ILD) classification has overlapping clinical presentations and outcomes. Cluster analysis modeling is a valuable tool in identifying distinct clinical phenotypes in heterogeneous diseases. However, this approach has yet to be implemented in ILD. METHODS: Using cluster analysis, we identified novel ILD phenotypes among subjects from a longitudinal ILD cohort and stratified outcomes by phenotypic clusters compared to subgroups by current American Thoracic Society (ATS)/European Respiratory Society (ERS) ILD classification criteria...
September 27, 2017: Chest
https://www.readbyqxmd.com/read/28963678/serial-automated-quantitative-ct-analysis-in-idiopathic-pulmonary-fibrosis-functional-correlations-and-comparison-with-changes-in-visual-ct-scores
#6
Joseph Jacob, Brian J Bartholmai, Srinivasan Rajagopalan, Maria Kokosi, Ryoko Egashira, Anne Laure Brun, Arjun Nair, Simon L F Walsh, Ronald Karwoski, Athol U Wells
OBJECTIVES: To determine whether computer-based CT quantitation of change can improve on visual change quantification of parenchymal features in IPF. METHODS: Sixty-six IPF patients with serial CT imaging (6-24 months apart) had CT features scored visually and with a computer software tool: ground glass opacity, reticulation and honeycombing (all three variables summed as interstitial lung disease extent [ILD]) and emphysema. Pulmonary vessel volume (PVV) was estimated by computer only...
September 29, 2017: European Radiology
https://www.readbyqxmd.com/read/28957390/quantitative-evaluation-of-interstitial-pneumonia-using-3d-curved-high-resolution-ct-imaging-parallel-to-the-chest-wall-a-pilot-study
#7
Hiroyasu Umakoshi, Shingo Iwano, Tsutomu Inoue, Yuanzhong Li, Shinji Naganawa
OBJECTIVES: To quantify the imaging findings of patients with interstitial pneumonia (IP) and emphysema using three-dimensional curved high-resolution computed tomography (3D-cHRCT) at a constant depth from the chest wall, and compare the results to visual assessment of IP and each patient's diffusing capacity of the lungs for carbon monoxide (DLco). METHODS: We retrospectively reviewed the axial CT findings and pulmonary function test results of 95 patients with lung cancer (72 men and 23 women, aged 45-84 years) with or without IP, as follows: non-IP (n = 47), mild IP (n = 31), and moderate IP (n = 17)...
2017: PloS One
https://www.readbyqxmd.com/read/28947036/possible-uip-pattern-on-high-resolution-computed-tomography-is-associated-with-better-survival-than-definite-uip-in-ipf-patients
#8
Margaret L Salisbury, Leslie B Tolle, Meng Xia, Susan Murray, Nabihah Tayob, Anoop M Nambiar, Shelley L Schmidt, Amir Lagstein, Jeffery L Myers, Barry H Gross, Ella A Kazerooni, Baskaran Sundaram, Aamer R Chughtai, Fernando J Martinez, Kevin R Flaherty
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a progressive fibrosing lung disease of unknown etiology. Inter-society consensus guidelines on IPF diagnosis and management outline radiologic patterns including definite usual interstitial pneumonia (UIP), possible UIP, and inconsistent with UIP. We evaluate these diagnostic categories as prognostic markers among patients with IPF. METHODS: Included subjects had biopsy-proven UIP, a multidisciplinary team diagnosis of IPF, and a baseline high-resolution computed tomography (HRCT)...
October 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28932560/cost-and-effectiveness-of-lung-lobectomy-by-video-assisted-thoracic-surgery-for-lung-cancer
#9
Juan J Mafé, Beatriz Planelles, Santos Asensio, Jorge Cerezal, María-Del-Mar Inda, Javier Lacueva, Maria-Dolores Esteban, Luis Hernández, Concepción Martín, Benno Baschwitz, Ana M Peiró
BACKGROUND: Video-assisted thoracic surgery (VATS) emerged as a minimally invasive surgery for diseases in the field of thoracic surgery. We herein reviewed our experience on thoracoscopic lobectomy for early lung cancer and evaluated Health System use. METHODS: A cost-effectiveness study was performed comparing VATS vs. open thoracic surgery (OPEN) for lung cancer patients. Demographic data, tumor localization, dynamic pulmonary function tests [forced vital capacity (FVC), forced expiratory volume in one second (FEV1), diffusion capacity (DLCO) and maximal oxygen uptake (VO2max)], surgical approach, postoperative details, and complications were recorded and analyzed...
August 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28929667/-efficacy-and-safety-of-danhong-injection-for-idiopathic-pulmonary-fibrosis%C3%AF-meta-analysis
#10
Li-Li Xin, Miao Jiang, Geng Zhang, Jie-Ning Gong
To systematically review the efficacy and safety of Danhong injection for patients with idiopathic pulmonary fibrosis(IPF), two researchers electronically searched PubMed, EMbase, Web of Science, Cochrane Library, CNKI, CBM, WanFang Data and VIP databases from the date of establishment to May 2016 for all randomized controlled trials(RCTs) and quasi-RCTs on the use of Danhong injection in patients with IPF. Manual search in relevant journals and search of relevant literature on other websites were also performed...
October 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28915226/pulmonary-vascular-function-and-aerobic-exercise-capacity-at-moderate-altitude
#11
Vitalie Faoro, Gael Deboeck, Marco Vicenzi, Anne-Fleur Gaston, Bamodi Simaga, Grégory Doucende, Ilona Hapkova, Emma Roca, Enric Subirats, Fabienne Durand, Robert Naeije
PURPOSE: There has been suggestion that a greater "pulmonary vascular reserve" defined by a low pulmonary vascular resistance (PVR) and a high lung diffusing capacity (DL) allow for a superior aerobic exercise capacity. How pulmonary vascular reserve might affect exercise capacity at moderate altitude is not known. METHODS: Thirty-eight healthy subjects underwent an exercise stress echocardiography of the pulmonary circulation, combined with measurements of DL for nitric oxide (NO) and carbon monoxide (CO) and a cardiopulmonary exercise test at sea level and at an altitude of 2250 m...
October 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28906550/efficacy-and-safety-of-autologous-haematopoietic-stem-cell-transplantation-in-systemic-sclerosis-a-systematic-review-of-literature
#12
A Eyraud, L Scouppe, T Barnetche, E Forcade, E Lazaro, P Duffau, C Richez, J Seneschal, M-E Truchetet
We aimed at assessing the efficacy of autologous haematopoietic stem cell transplantation (HSCT) for skin sclerosis and lung function in systemic sclerosis (SSc). We performed a systematic literature review in the Pubmed and Scopus databases from the earliest records to March 2016. We assessed quality using the Cochrane tool for randomized studies, Newcastle-Ottawa scale for controlled-cohort studies and an 18-item quality appraisal checklist for case series. The primary outcome was the improvement of skin thickening using the modified Rodnan Skin Score (mRSS)...
September 14, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28876128/influence-of-inhaled-amiloride-on-lung-fluid-clearance-in-response-to-normobaric-hypoxia-in-healthy-individuals
#13
Courtney M Wheatley, Sarah E Baker, Bryan J Taylor, Manda L Keller-Ross, Steven C Chase, Alex R Carlson, Robert J Wentz, Eric M Snyder, Bruce D Johnson
Wheatley, Courtney M., Sarah E. Baker, Bryan J. Taylor, Manda L. Keller-Ross, Steven C. Chase, Alex R. Carlson, Robert J. Wentz, Eric M. Snyder, and Bruce D. Johnson. Influence of inhaled amiloride on lung fluid clearance in response to normobaric hypoxia in healthy individuals. High Alt Med Biol 00:000-000, 2017. AIM: To investigate the role of epithelial sodium channels (ENaC) on lung fluid clearance in response to normobaric hypoxia, 20 healthy subjects were exposed to 15 hours of hypoxia (fraction of inspired oxygen [FiO2] = 12...
September 6, 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/28875146/importance-of-serial-changes-in-biomarkers-in-idiopathic-pulmonary-fibrosis
#14
Akihiko Sokai, Kiminobu Tanizawa, Tomohiro Handa, Kumiko Kanatani, Takeshi Kubo, Kohei Ikezoe, Yoshinari Nakatsuka, Shinsaku Tokuda, Toru Oga, Toyohiro Hirai, Sonoko Nagai, Kazuo Chin, Michiaki Mishima
The clinical significance of serial changes in serum biomarkers in patients with idiopathic pulmonary fibrosis (IPF) remains to be established. This retrospective study was conducted to clarify the associations of serial changes in serum Krebs von den Lungen-6 (KL-6) and surfactant protein-D (SP-D) with changes in physiological indices and overall mortality in IPF. The study subjects were 75 patients with IPF. The 6 month change in serum KL-6 was significantly correlated with changes in the percentage of the predicted forced vital capacity (FVC % pred) and the percentage of the predicted diffusing capacity of the lung for carbon monoxide (% DLCO), while the 6 month change in serum SP-D was correlated only with % DLCO...
July 2017: ERJ Open Research
https://www.readbyqxmd.com/read/28871617/what-is-expected-in-lung-function-after-lung-transplantation-due-to-end-stage-pulmonary-silicosis
#15
Luzielio Alves Sidney-Filho, Guilherme Watte, Pedro Augusto Reck Dos Santos, Sadi Marcelo Schio, Spencer Marcantonio Camargo, Fabíola Adélia Perin, Bruno Hochhegger, Jose Carlos Felicetti, Jose de Jesus Peixoto Camargo, Jose da Silva Moreira
In this study, we aimed to determine the impact of lung transplantation (LTx) on pulmonary function tests (PFTs) and survival among patients with end-stage silicosis. We included patients with end-stage silicosis on the wait list for LTx, between January 1989 and July 2015 (N = 26). Sixteen of these patients received LTx; 10 were eligible, but did not undergo LTx (non-LTx) during the study period. Retrospective information on PFTs (spirometry [volumes and flows], 6-minute walking test [6MWT], and DLCO) was retrieved from patients' medical charts, including baseline information for all patients and follow-up information for the LTx...
September 4, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/28862397/empire-registry-czech-part-impact-of-demographics-pulmonary-function-and-hrct-on-survival-and-clinical-course-in-idiopathic-pulmonary-fibrosis
#16
Martina Doubková, Jan Švancara, Michal Svoboda, Martina Šterclová, Vladimír Bartoš, Martina Plačková, Ladislav Lacina, Monika Žurková, Ilona Binková, Radka Bittenglová, Vladimíra Lošťáková, Zdeněk Merta, Lenka Šišková, Richard Tyl, Pavlína Lisá, Hana Šuldová, František Petřík, Jana Pšikalová, Vladimír Řihák, Tomáš Snížek, Pavel Reiterer, Jiří Homolka, Pavlína Musilová, Jaroslav Lněnička, Peter Palúch, Roman Hrdina, Renata Králová, Hana Hortvíková, Jana Strenková, Martina Vašáková
INTRODUCTION: Prognostic factors of idiopathic pulmonary fibrosis (IPF) currently recognized include changes in vital capacity and radiologic findings. However, most of the prognostic studies in IPF are based on clinical studies with preselected IPF populations. Therefore, we decided to analyze the factors influencing IPF prognosis based on the real-practice data from our IPF registry. METHODS: Data of 514 subjects consecutively entered since 2012 into Czech EMPIRE IPF registry were analyzed...
September 1, 2017: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/28860741/comparison-of-world-health-organization-and-asia-pacific-body-mass-index-classifications-in-copd-patients
#17
Jeong Uk Lim, Jae Ha Lee, Ju Sang Kim, Yong Il Hwang, Tae-Hyung Kim, Seong Yong Lim, Kwang Ha Yoo, Ki-Suck Jung, Young Kyoon Kim, Chin Kook Rhee
INTRODUCTION: A low body mass index (BMI) is associated with increased mortality and low health-related quality of life in patients with COPD. The Asia-Pacific classification of BMI has a lower cutoff for overweight and obese categories compared to the World Health Organization (WHO) classification. The present study assessed patients with COPD among different BMI categories according to two BMI classification systems: WHO and Asia-Pacific. PATIENTS AND METHODS: Patients with COPD aged 40 years or older from the Korean COPD Subtype Study cohort were selected for evaluation...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28855034/-clinical-characteristics-of-118-cases-of-chronic-obstructive-pulmonary-disease-complicated-with-primary-bronchopulmonary-carcinoma
#18
Songlin Zhao, Xiuhong Nie, Lin Zhang, Wei Zhang, Han Xiao
BACKGROUND: The aim of this study is to investigate the clinical characteristics of patients with primary bronchopulmonary carcinoma complicated with chronic obstructive pulmonary disease (COPD), and to optimize the early diagnoses in the coexistence of COPD and primary bronchopulmonary carcinoma. METHODS: The clinical data of 118 patients with COPD complicated with primary bronchopulmonary carcinoma were analyzed retrospectively, including age, sex, smoking history, smoking index, clinical symptoms and signs, pathological type, staging, metastasis site and lung function index...
August 20, 2017: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/28841877/influence-of-resting-lung-diffusion-on-exercise-capacity-in-patients-with-copd
#19
Mehrdad Behnia, Courtney Wheatley, Alberto Avolio, Bruce Johnson
BACKGROUND: Lung diffusing capacity for carbon monoxide (DLCO) gives an overall assessment of functional lung surface area for gas exchange and can be assessed using various methods. DLCO is an important factor in exercise intolerance in patients with chronic obstructive pulmonary disease (COPD). We investigated if the intra-breath (IBDLCO) method may give a more sensitive measure of available gas exchange surface area than the more typical single breath (SBDLCO) method and if COPD subjects with the largest resting DLCO relative to pulmonary blood flow (Qc) would have a more preserved exercise capacity...
August 25, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/28808493/pulmonary-consequences-of-hypothyroidism
#20
Samiaa Hamdy Sadek, Walaa Anwar Khalifa, Ahmad Metwally Azoz
BACKGROUND: Although hypothyroidism has an insidious onset and relatively asymptomatic, exertional dyspnea and fatigue can be the presenting complaints. OBJECTIVES: The aim is to assess functional lung impairment in hypothyroid patients both at rest and during exercise. METHODS: A case-control study was carried out on 42 patients with newly diagnosed hypothyroidism and 12 control subjects. Hypothyroidism was diagnosed based on high value of thyroid stimulating hormone (TSH) ≥6 μIU/ml, and low value of free thyroxin (FT4) ≤0...
July 2017: Annals of Thoracic Medicine
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