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Hyperinflation

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https://www.readbyqxmd.com/read/28926283/more-options-for-treating-severe-hyperinflation-in-advanced-emphysema
#1
Gerard Criner
No abstract text is available yet for this article.
September 19, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28919730/a-new-functional-method-to-choose-the-target-lobe-for-lung-volume-reduction-in-emphysema-comparison-with-the-conventional-densitometric-method
#2
Juergen Hetzel, Michael Boeckeler, Marius Horger, Ahmed Ehab, Christopher Kloth, Robert Wagner, Lutz Freitag, Dirk-Jan Slebos, Richard Alexander Lewis, Maik Haentschel
BACKGROUND: Lung volume reduction (LVR) improves breathing mechanics by reducing hyperinflation. Lobar selection usually focuses on choosing the most destroyed emphysematous lobes as seen on an inspiratory CT scan. However, it has never been shown to what extent these densitometric CT parameters predict the least deflation of an individual lobe during expiration. The addition of expiratory CT analysis allows measurement of the extent of lobar air trapping and could therefore provide additional functional information for choice of potential treatment targets...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28893857/changes-in-dynamic-lung-mechanics-after-lung-volume-reduction-coil-treatment-of-severe-emphysema
#3
Demosthenes Makris, Sylvie Leroy, Johana Pradelli, Jonathan Benzaquen, Hervé Guenard, Jeanne-Marie Perotin, Spyros Zakynthinos, Epaminondas Zakynthinos, Gaëtan Deslee, Charles Hugo Marquette
We assessed the relationships between changes in lung compliance, lung volumes and dynamic hyperinflation in patients with emphysema who underwent bronchoscopic treatment with nitinol coils (coil treatment) (n=11) or received usual care (UC) (n=11). Compared with UC, coil treatment resulted in decreased dynamic lung compliance (CLdyn) (p=0.03) and increased endurance time (p=0.010). The change in CLdyn was associated with significant improvement in FEV1 and FVC, with reduction in residual volume and intrinsic positive end-expiratory pressure, and with increased inspiratory capacity at rest/and at exercise...
September 11, 2017: Thorax
https://www.readbyqxmd.com/read/28891754/mounier-kuhn-syndrome-presenting-with-recurrent-atelectasis
#4
Christine Quentin, Nicolas Lefevre, Eddy Bodart, Laurence Hanssens
Objective and importance Mounier Kuhn syndrome is usually diagnosed in adulthood, and only a few cases have been described in childhood. Clinical presentation We present the case of a seven-year-old boy suffering from recurrent pneumonia and atelectasis. Intervention Previously performed chest X-rays showed bilateral hyperinflation and tracheobronchomegaly. Chest computed tomography (CT) confirmed the presence of distal enlargement of trachea and bronchi. Tracheobronchomegaly associated with recurrent respiratory tract infections is consistent with Mounier Kuhn syndrome...
September 11, 2017: Acta Clinica Belgica
https://www.readbyqxmd.com/read/28886040/residual-volume-total-lung-capacity-ratio-confers-limited-additive-significance-to-lung-clearance-index-for-assessment-of-adults-with-bronchiectasis
#5
Wei-Jie Guan, Jing-Jing Yuan, Yan Huang, Hui-Min Li, Rong-Chang Chen, Nan-Shan Zhong
BACKGROUND: Mosaicism and hyperinflation are common pathophysiologic features of bronchiectasis. The magnitude of ventilation heterogeneity might have been affected by the degree of hyperinflation. Some studies have evaluated the discriminative performance of lung clearance index (LCI) in bronchiectasis patients, but the additive diagnostic value of hyperinflation metrics to LCI is unknown. OBJECTIVE: To compare LCI and the ratio of residual volume to total lung capacity (RV/TLC), along with the LCI normalized with RV/TLC, in terms of discriminative performance, correlation and concordance with clinical variables in adults with bronchiectasis...
2017: PloS One
https://www.readbyqxmd.com/read/28885054/a-multicenter-rct-of-zephyr%C3%A2-endobronchial-valve-treatment-in-heterogeneous-emphysema-transform
#6
Samuel V Kemp, Dirk-Jan Slebos, Alan Kirk, Malgorzata Kornaszewska, Kris Carron, Lars Ek, Gustav Broman, Gunnar Hillerdal, Herve Mal, Christophe Pison, Amandine Briault, Nicola Downer, Kaid Darwiche, Jagan Rao, Ralf-Harto Hübner, Christof Ruwwe-Glosenkamp, Valéry Trosini-Desert, Ralf Eberhardt, Felix J Herth, Eric Derom, Thomas Malfait, Pallav L Shah, Justin L Garner, Nick H Ten Hacken, Hazem Fallouh, Sylvie Leroy, Charles H Marquette
RATIONALE: Single-center RCTs of Zephyr Endobronchial Valve (EBV) treatment have demonstrated benefit in severe heterogeneous emphysema. This is the first multicenter study evaluating this treatment approach. OBJECTIVES: To evaluate the efficacy and safety of Zephyr EBVs in patients with heterogeneous emphysema and absence of collateral ventilation. METHODS: Prospective, multicenter 2:1 RCT of EBVs plus standard of care or standard of care (SoC) alone...
September 8, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28883722/activate-the-effect-of-aclidinium-formoterol-on-hyperinflation-exercise-capacity-and-physical-activity-in-patients-with-copd
#7
Henrik Watz, Thierry Troosters, Kai M Beeh, Judith Garcia-Aymerich, Pierluigi Paggiaro, Eduard Molins, Massimo Notari, Antonio Zapata, Diana Jarreta, Esther Garcia Gil
The Phase IV, 8-week, randomized, double-blind, placebo-controlled ACTIVATE study (NCT02424344) evaluated the effect of aclidinium/formoterol (AB/FF) 400/12 μg twice daily on lung hyperinflation, exercise capacity, and physical activity in patients with moderate-to-severe COPD. Patients received AB/FF (n=134) or placebo (n=133) (1:1) via the Genuair™/Pressair(®) dry powder inhaler for 8 weeks. From Weeks 5 to 8, all patients participated in behavioral intervention (BI; daily messages providing step goals)...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28883532/patterns-of-oxygen-pulse-curve-in-response-to-incremental-exercise-in-patients-with-chronic-obstructive-pulmonary-disease-an-observational-study
#8
Ming-Lung Chuang, I-Feng Lin, Shih-Feng Huang, Meng-Jer Hsieh
In COPD, pulmonary hyperinflation causes decreased stroke volume thereby decreased oxygen pulse (O2P). While O2P flattening is related to myocardial ischemia in cardiac patients, O2P patterns have seldom been explored in COPD. The aims of the study were to investigate O2P-curve patterns and associated factors in COPD. Seventy-five patients with stable COPD were enrolled. The demographics, cardiac size, physiological measurements and stress EKG were compared among O2P-curve pattern groups. An algorithm to identify O2P-curve patterns was developed in 28 patients...
September 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28882651/in-cystic-fibrosis-lung-clearance-index-is-sensitive-to-detecting-abnormalities-appearing-at-exercise-in-children-with-normal-spirometry
#9
Riyadh Chelabi, Thibaud Soumagne, Alicia Guillien, Marc Puyraveau, Bruno Degano
Symptom-limited incremental cardiopulmonary exercise test was performed in school-age children with clinically stable cystic fibrosis (CF), all with normal spirometry. Physiological parameters were compared between patients with normal lung clearance index (LCI; n=6) and patients with elevated LCI (n=6). Dyspnoea ratings during exercise were similar in both groups. Although no patient had significant dynamic hyperinflation, end-expiratory lung volumes were higher throughout exercise in patients with elevated LCI...
September 4, 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/28882178/differential-lung-ventilation-via-tracheostomy-using-two-endotracheal-tubes-in-an-infant-a-case-report
#10
Demet Demirkol, Yasemin Ataman, Gökhan Gündoğdu
BACKGROUND: This case report presents differential lung ventilation in an infant. The aim is to define an alternative technique for performing differential lung ventilation in children. To the best of our knowledge, this is the first report of this kind. CASE PRESENTATION: A 4.2-kg, 2.5-month-old Asian boy was referred to our facility with refractory hypoxemia and hypercarbia due to asymmetric lung disease with atelectasis of the left lung and hyperinflation of the right lung...
September 8, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28873355/pulmonary-interstitial-glycogenosis-associated-with-a-spectrum-of-neonatal-pulmonary-disorders
#11
Ernest Cutz, Rose Chami, Sharon Dell, Jacob Langer, David Manson
Primary or isolated pulmonary interstitial glycogenosis (PIG) is a rare disease presenting as tachypnea and hypoxemia during the perinatal period. A diffuse interstitial infiltrate with focal hyperinflation is visible on chest imaging. The biopsy findings include diffuse expansion of the interstitium by spindle-shaped cells with pale cytoplasm that, on electron microscopy (EM), are poorly differentiated mesenchymal cells containing abundant monoparticulate glycogen. This glycogenosis appears to be a transient abnormality, usually with a favorable prognosis...
September 2, 2017: Human Pathology
https://www.readbyqxmd.com/read/28866641/extrathoracic-hyperinflation
#12
Marie Bruyneel, Vincent Ninane
No abstract text is available yet for this article.
September 2, 2017: Thorax
https://www.readbyqxmd.com/read/28831577/chest-radiographic-features-of-human-metapneumovirus-infection-in-pediatric-patients
#13
Melissa A Hilmes, F Daniel Dunnavant, Sudha P Singh, Wendy D Ellis, Daniel C Payne, Yuwei Zhu, Marie R Griffin, Kathryn M Edwards, John V Williams
BACKGROUND: Human metapneumovirus (HMPV) was identified in 2001 and is a common cause of acute respiratory illness in young children. The radiologic characteristics of laboratory-confirmed HMPV acute respiratory illness in young children have not been systematically assessed. OBJECTIVE: We systematically evaluated the radiographic characteristics of acute respiratory illness associated with HMPV in a prospective cohort of pediatric patients. MATERIALS AND METHODS: We included chest radiographs from children <5 years old with acute respiratory illness who were enrolled in the prospective New Vaccine Surveillance Network (NVSN) study from 2003 to 2009 and were diagnosed with HMPV by reverse transcription-polymerase chain reaction (RT-PCR)...
August 22, 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/28828360/transpulmonary-pressure-importance-and-limits
#14
REVIEW
Domenico Luca Grieco, Lu Chen, Laurent Brochard
Transpulmonary pressure (PL) is computed as the difference between airway pressure and pleural pressure and separates the pressure delivered to the lung from the one acting on chest wall and abdomen. Pleural pressure is measured as esophageal pressure (PES) through dedicated catheters provided with esophageal balloons. We discuss the role of PL in assessing the effects of mechanical ventilation in patients with acute respiratory distress syndrome (ARDS). In the supine position, directly measured PL represents the pressure acting on the alveoli and airways...
July 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28820781/inadvertent-endotracheal-cuff-hyperinflation-diagnosed-by-magnetic-resonance-imaging
#15
Leon Vorobeichik, Shi-Joon Yoo, Karen A Cybulski
No abstract text is available yet for this article.
August 18, 2017: Anesthesiology
https://www.readbyqxmd.com/read/28817821/endoscopic-lung-volume-reduction-an-expert-panel-recommendation-update-2017
#16
Felix J F Herth, Dirk-Jan Slebos, Gerard J Criner, Pallav L Shah
Interest in endoscopic lung volume reduction (ELVR) technologies for emphysema is consistently growing. In the last couple of months, several endoscopic options (e.g., endo- or intrabronchial valves, coil implants, and thermal vapor ablation) that have been evaluated in randomized controlled trials have been reported with the ultimate goal of improving respiratory mechanics and alleviating chronic dyspnea. Patients presenting with severe air trapping and thoracic hyperinflation have the greatest potential to derive benefit from ELVR procedures...
2017: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/28801407/the-boundaries-of-mild-chronic-obstructive-pulmonary-disease-copd-design-of-the-searching-clinical-copd-onset-soon-study
#17
Gonzalo Labarca, Andrea Bustamante, Gonzalo Valdivia, Rodrigo Díaz, Álvaro Huete, Paul Mac Nab, Laura Mendoza, Jaime Leppe, Carmen Lisboa, Fernando Saldías, Orlando Díaz
INTRODUCTION: Clinical onset of chronic obstructive pulmonary disease (COPD) is the point at which the disease is first identifiable by physicians. It is a poorly defined stage which seems to include both mild spirometric and non-spirometric disease, and could be described as early grade COPD, for practical purposes. While dyspnoea; chronic bronchitis and CT imaging evidence of emphysema and airway disease may be present very early, the lone significance of dyspnoea, the most relevant symptom in COPD in identifying these individuals, has been scarcely assessed...
August 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28774473/hyperinflation-of-the-left-anterior-basal-segment-a-new-sign-of-pectus-excavatum-severity-on-ct
#18
S Singh, S B Greenberg
AIM: To describe a new finding in patients with pectus excavatum - left lower lobe anterior basal segment hyperinflation [LABSH]. A secondary objective is to determine the frequency of the new finding and association with pectus excavatum severity. MATERIAL AND METHODS: The study population included 52 children who underwent preoperative computed tomography (CT) for the evaluation of pectus excavatum. A control group of 50 children was obtained after evaluating 137 CT examinations performed for other reasons...
July 31, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28765494/effects-of-expiratory-positive-airway-pressure-on-exercise-tolerance-dynamic-hyperinflation-and-dyspnea-in-copd
#19
Ricardo Gass, Pietro Merola, Mariane B Monteiro, Dannuey M Cardoso, Dulciane N Paiva, Paulo Jz Teixeira, Marli M Knorst, Danilo C Berton
INTRODUCTION: The application of expiratory positive airway pressure (EPAP) in patients with COPD during exercise may reduce dynamic hyperinflation, while, on the other hand, it can increase the resistive work of breathing. Therefore, we evaluated the effects of 2 intensities of EPAP during exercise on tolerance, dynamic hyperinflation, and dyspnea in subjects with moderate to very severe COPD. METHODS: We performed a cross-sectional, experimental, 4-visit study...
August 1, 2017: Respiratory Care
https://www.readbyqxmd.com/read/28736210/effects-of-positive-expiratory-pressure-on-chest-wall-volumes-in-subjects-with-stroke-compared-to-healthy-controls-a-case-control-study
#20
Elis E A Cabral, Vanessa R Resqueti, Illia N D F Lima, Lucien P Gualdi, Andrea Aliverti, Guilherme A F Fregonezi
BACKGROUND: Alterations in respiratory system kinematics in stroke lead to restrictive pattern associated with decreased lung volumes. Chest physical therapy, such as positive expiratory pressure, may be useful in the treatment of these patients; however, the optimum intensity to promote volume and motion changes of the chest wall remains unclear. OBJECTIVE: To assess the effect of different intensities of positive expiratory pressure on chest wall kinematics in subjects with stroke compared to healthy controls...
July 8, 2017: Brazilian Journal of Physical Therapy
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