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Acute mountain sickness

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https://www.readbyqxmd.com/read/29428576/ganglioside-gm1-protects-against-high-altitude-cerebral-edema-in-rats-by-suppressing-the-oxidative-stress-and-inflammatory-response-via-the-pi3k-akt-nrf2-pathway
#1
Gu Gong, Liang Yin, Libang Yuan, Daming Sui, Yangyang Sun, Haiyu Fu, Liang Chen, Xiaowu Wang
High altitude cerebral edema (HACE) is a severe type of acute mountain sickness (AMS) that occurs in response to a high altitude hypobaric hypoxic (HH) environment. GM1 monosialoganglioside can alleviate brain injury under adverse conditions including amyloid-β-peptide, ischemia and trauma. However, its role in HACE-induced brain damage remains poorly elucidated. In this study, GM1 supplementation dose-dependently attenuated increase in rat brain water content (BWC) induced by hypobaric chamber (7600 m) exposurefor 24 h...
February 8, 2018: Molecular Immunology
https://www.readbyqxmd.com/read/29387446/acetazolamide-reduces-exercise-capacity-following-a-5-day-ascent-to-4559-m-in-a-randomised-study
#2
Arthur R Bradwell, Kimberley Ashdown, Carla Rue, John Delamere, Owen D Thomas, Samuel J E Lucas, Alex D Wright, Stephen J Harris, Stephen D Myers
Objective: To assess whether acetazolamide (Az), used prophylactically for acute mountain sickness (AMS), alters exercise capacity at high altitude. Methods: Az (500 mg daily) or placebo was administered to 20 healthy adults (aged 36±20 years, range 21-77), who were paired for age, sex, AMS susceptibility and weight, in a double-blind, randomised manner. Participants ascended over 5 days to 4559 m, then exercised to exhaustion on a bicycle ergometer, while recording breath-by-breath gas measurements...
2018: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/29352170/plasma-proteomic-study-of-acute-mountain-sickness-susceptible-and-resistant-individuals
#3
Hui Lu, Rong Wang, Wenbin Li, Hua Xie, Chang Wang, Ying Hao, Yuhuan Sun, Zhengping Jia
Although extensive studies have focused on the development of acute mountain sickness (AMS), the exact mechanisms of AMS are still obscure. In this study, we used isobaric tags for relative and absolute quantitation (iTRAQ) proteomic analysis to identify novel AMS-associated biomarkers in human plasma. After 9 hours of hypobaric hypoxia the abundance of proteins related to tricarboxylic acid (TCA) cycle, glycolysis, ribosome, and proteasome were significantly reduced in AMS resistant (AMS-) group, but not in AMS susceptible (AMS+) group...
January 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29282538/barometric-pressure-change-and-heart-rate-response-during-sleeping-at-%C3%A2-3000%C3%A2-m-altitude
#4
Masahiro Horiuchi, Junko Endo, Yoko Handa, Hiroshi Nose
We investigated effects of change in barometric pressure (P B) with climate change on heart rate (HR) during sleep at 3000 m altitude. Nineteen healthy adults (15 males and four females; mean age 32 years) participated in this study. We measured P B (barometry) and HR (electrocardiography) every minute during their overnight stay in a mountain lodge at ~ 3000 m. We also measured resting arterial oxygen saturation (SpO2) and evaluated symptoms of acute mountain sickness (AMS) by using the Lake Louise Questionnaire at 2305 and 3000 m, respectively...
December 27, 2017: International Journal of Biometeorology
https://www.readbyqxmd.com/read/29259975/relationship-between-smoking-and-acute-mountain-sickness-a-meta-analysis-of-observational-studies
#5
REVIEW
Cristina Masuet-Aumatell, Alba Sánchez-Mascuñano, Fernando Agüero Santangelo, Sergio Morchón Ramos, Josep Maria Ramon-Torrell
Aims: Previous epidemiological investigations of the relationship between smoking and acute mountain sickness (AMS) risk yielded inconsistent findings. Therefore, a meta-analysis of observational studies was performed to determine whether smoking is related to the development of AMS. Methods: Searches were performed on PubMed, Scopus, Embase, and Web of Science for relevant studies that were published before November 2016 reporting smoking prevalence and AMS. Two evaluators independently selected studies, extracted data, and assessed study quality...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29202898/isolated-psychosis-during-exposure-to-very-high-and-extreme-altitude-characterisation-of-a-new-medical-entity
#6
Katharina Hüfner, Hermann Brugger, Eva Kuster, Franziska Dünsser, Agnieszka E Stawinoga, Rachel Turner, Iztok Tomazin, Barbara Sperner-Unterweger
BACKGROUND: Psychotic episodes during exposure to very high or extreme altitude have been frequently reported in mountain literature, but not systematically analysed and acknowledged as a distinct clinical entity. METHODS: Episodes reported above 3500 m altitude with possible psychosis were collected from the lay literature and provide the basis for this observational study. Dimensional criteria of the Diagnostic and Statistical Manual of Mental Disorders were used for psychosis, and the Lake Louise Scoring criteria for acute mountain sickness and high-altitude cerebral oedema (HACE)...
December 5, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/29172727/objective-versus-self-reported-sleep-quality-at-high-altitude
#7
Paul J Anderson, Christina M Wood-Wentz, Kent R Bailey, Bruce D Johnson
Anderson, Paul J., Christina M. Wood-Wentz, Kent R. Bailey, and Bruce D. Johnson. Objective versus self-reported sleep quality at high altitude. High Alt Med Biol. 16:000-000, 2017. BACKGROUND: Previous studies have found little relationship between polysomnography and a diagnosis of acute mountain sickness (AMS) using the Lake Louise Symptom Questionnaire (LLSQ). The correlation between sleep question responses on the LLSQ and polysomnography results has not been explored. We compared LLSQ sleep responses and polysomnography data from our previous study of workers rapidly transported to the South Pole...
November 27, 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/29166795/pharmacological-interventions-for-preventing-acute-mountain-sickness-a-network-meta-analysis-and-trial-sequential-analysis-of-randomized-clinical-trials
#8
Kannan Sridharan, Gowri Sivaramakrishnan
BACKGROUND: Individuals ascending to high altitude are at a risk of getting acute mountain sickness (AMS). The present study is a network meta-analysis comparing all the interventions available to prevent AMS. METHODS: Electronic databases were searched for randomized clinical trials evaluating the use of drugs to prevent AMS. Incidence of AMS was the primary outcome and incidence of severe AMS, paraesthesia (as side effect of acetazolamide use), headache and severe headache, and oxygen saturation were the secondary outcomes...
November 23, 2017: Annals of Medicine
https://www.readbyqxmd.com/read/29153259/reduction-of-olfactory-sensitivity-during-normobaric-hypoxia
#9
Tilman Huppertz, Jessica Freiherr, Bernhard Olzowy, Ulrich Kisser, Jutta Stephan, Gunther Fesl, Kathrin Haegler, Berend Feddersen, Rainald Fischer, Klaus Mees, Sven Becker
OBJECTIVE: Acute mountain sickness (AMS) is caused by a low partial pressure of oxygen and may occur above 2500m. The aim of this research was to evaluate olfactory and gustatory abilities of healthy subjects during baseline conditions and after seven hours of normobaric hypoxia. METHODS: Sixteen healthy subjects were assessed using the Sniffin' Sticks, as well as intensity and pleasantness ratings. Gustatory function was evaluated utilizing the Taste Strips. Experiments were carried out under baseline conditions (518m altitude) followed by a second testing session after seven hours of normobaric hypoxia exposure (comparable to 4000m altitude)...
November 15, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/29136449/does-this-patient-have-acute-mountain-sickness-the-rational-clinical-examination-systematic-review
#10
REVIEW
David Meier, Tinh-Hai Collet, Isabella Locatelli, Jacques Cornuz, Bengt Kayser, David L Simel, Claudio Sartori
Importance: Acute mountain sickness (AMS) affects more than 25% of individuals ascending to 3500 m (11 500 ft) and more than 50% of those above 6000 m (19 700 ft). AMS may progress from nonspecific symptoms to life-threatening high-altitude cerebral edema in less than 1% of patients. It is not clear how to best diagnose AMS. Objective: To systematically review studies assessing the accuracy of AMS diagnostic instruments, including the visual analog scale (VAS) score, which quantifies the overall feeling of sickness at altitude (VAS[O]; various thresholds), Acute Mountain Sickness-Cerebral score (AMS-C; ≥0...
November 14, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29136446/acute-mountain-sickness
#11
Jill Jin
No abstract text is available yet for this article.
November 14, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29074708/wearable-physiologic-sensors-and-real-time-algorithms-for-detection-of-acute-mountain-sickness
#12
Stephen R Muza
This is a mini-review of potential wearable physiological sensors and algorithms (process and equations) for detection of acute mountain sickness (AMS). Given the emerging status of this effort, the focus of the review is on the current clinical assessment of AMS, known risk factors (environmental, demographic and physiological), and current understanding of AMS pathophysiology. Studies that have examined a range of physiological variables to develop AMS prediction and/or detection algorithms are reviewed to provide insight and potential technological roadmaps for future development of real-time physiological sensors and algorithms to detect AMS...
October 26, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29042272/effects-of-dietary-nitrate-on-respiratory-physiology-at-high-altitude-results-from-the-xtreme-alps-study
#13
Andrew F Cumpstey, Philip J Hennis, Edward T Gilbert-Kawai, Bernadette O Fernandez, Matthieu Poudevigne, Alexandra Cobb, Paula Meale, Kay Mitchell, Helen Moyses, Helmut Pöhnl, Monty G Mythen, Michael P W Grocott, Martin Feelisch, Daniel S Martin
Nitric oxide (NO) production plays a central role in conferring tolerance to hypoxia. Tibetan highlanders, successful high-altitude dwellers for millennia, have higher circulating nitrate and exhaled NO (ENO) levels than native lowlanders. Since nitrate itself can reduce the oxygen cost of exercise in normoxia it may confer additional benefits at high altitude. Xtreme Alps was a double-blinded randomised placebo-controlled trial to investigate how dietary nitrate supplementation affects physiological responses to hypoxia in 28 healthy adult volunteers resident at 4559 m for 1 week; 14 receiving a beetroot-based high-nitrate supplement and 14 receiving a low-nitrate 'placebo' of matching appearance/taste...
December 1, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/29021909/managing-diabetes-at-high-altitude-personal-experience-with-support-from-a-multidisciplinary-physical-activity-and-diabetes-clinic
#14
Gary Malcolm, Sian Rilstone, Sivasujan Sivasubramaniyam, Carol Jairam, Stephen Chew, Nick Oliver, Neil E Hill
OBJECTIVE: Physical activity is important for well-being but can be challenging for people with diabetes. Data informing support of specialist activities such as climbing and high-altitude trekking are limited. A 42-year-old man with type 1 diabetes (duration 30 years) attended a Multidisciplinary Physical Activity and Diabetes Clinic planning to climb Mont Blanc during the summer and trek to Everest Base Camp in the autumn. His aims were to complete these adventures without his diabetes impacting on their success...
2017: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/28949829/performance-mood-and-anxiety-during-a-climb-of-mount-everest
#15
Heikki M Karinen, Martti T Tuomisto
Karinen, Heikki M., and Martti T. Tuomisto. Performance, mood, and anxiety during a climb of Mount Everest. High Alt Med Biol. 16:000-000, 2017. BACKGROUND: Various studies have shown the deleterious effects of high-altitude hypoxia on visual, motor, somatosensory, cognitive, and emotional function and also in intelligence tests, reaction time, speech comprehension, hand steadiness, visual contrast discrimination, and word association tests. Because optimal cognitive abilities may be crucial for mountain climbers' safety, this study was intended to evaluate the changes in cognitive performance, mood, and anxiety during an Everest expedition lasting almost 3 months...
September 26, 2017: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/28890440/inhaled-budesonide-for-acute-mountain-sickness
#16
EDITORIAL
Robert Naeije, Erik R Swenson
No abstract text is available yet for this article.
September 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28870508/inappropriate-dexamethasone-use-by-a-trekker-in-nepal-a-case-report
#17
Nicholas R Haslam, Rachel Garth, Nicola Kelly
We present a case of inappropriate dexamethasone use in a trekker in the Everest region of Nepal. We aim to increase awareness among health professionals of the possible use of this medication by trekkers and promote knowledge of potential complications. In this case, a previously altitude-naive trekker was prescribed prophylactic dexamethasone by physicians in a Western travel clinic before high-altitude trekking in Nepal. There were no indications for prophylactic medication nor for the use of dexamethasone...
December 2017: Wilderness & Environmental Medicine
https://www.readbyqxmd.com/read/28832689/incidence-and-severity-of-acute-mountain-sickness-and-associated-symptoms-in-children-trekking-on-xue-mountain-taiwan
#18
Fei-Ying Cheng, Mei-Jy Jeng, Yin-Chou Lin, Shih-Hao Wang, Shih-Hao Wu, Wen-Cheng Li, Kuo-Feng Huang, Te-Fa Chiu
BACKGROUND: Acute mountain sickness (AMS) occurs in non-acclimatized people after an acute ascent to an altitude of 2,500 m or higher. The aim of this study was to examine the incidence and severity of AMS and associated symptoms in children. METHODS: The prospective observational study included 197 healthy, non-acclimatized 11 and 12-year-old children trekking the round-trip from the trailhead to the summit of Xue Mountain, Taiwan (2,179 m to 3,886 m) over 3 days...
2017: PloS One
https://www.readbyqxmd.com/read/28810235/obesity-as-a-conditioning-factor-for-high-altitude-diseases
#19
Rocío San Martin, Julio Brito, Patricia Siques, Fabiola León-Velarde
Obesity, a worldwide epidemic, has become a major health burden because it is usually accompanied by an increased risk for insulin resistance, diabetes, hypertension, cardiovascular diseases, and even some kinds of cancer. It also results in associated increases in healthcare expenditures and labor and economic consequences. There are also other fields of medicine and biology where obesity or being overweight play a major role, such as high-altitude illnesses (acute mountain sickness, hypoxic pulmonary hypertension, and chronic mountain sickness), where an increasing relationship among these two morbid statuses has been demonstrated...
2017: Obesity Facts
https://www.readbyqxmd.com/read/28798201/remote-ischemic-preconditioning-does-not-prevent-acute-mountain-sickness-after-rapid-ascent-to-3450-m
#20
Marc M Berger, Franziska Macholz, Lukas Lehmann, Daniel Dankl, Marcel Hochreiter, Bernhard Bacher, Peter Bärtsch, Heimo Mairbäurl
Remote ischemic preconditioning (RIPC) has been shown to protect remote organs, such as the brain and the lung, from damage induced by subsequent hypoxia or ischemia. Acute mountain sickness (AMS) is a syndrome of non-specific neurologic symptoms and in high altitude pulmonary edema excessive hypoxic pulmonary vasoconstriction (HPV) plays a pivotal role. We hypothesized that RIPC protects the brain from AMS and attenuates the magnitude of HPV after rapid ascent to 3450 m. Forty non-acclimatized volunteers were randomized into 2 groups...
August 10, 2017: Journal of Applied Physiology
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