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https://www.readbyqxmd.com/read/28102840/cancer-associated-fibroblasts-enact-field-cancerization-by-promoting-extratumoral-oxidative-stress
#1
Jeremy Soon Kiat Chan, Ming Jie Tan, Ming Keat Sng, Ziqiang Teo, Terri Phua, Chee Chong Choo, Liang Li, Pengcheng Zhu, Nguan Soon Tan
Histological inspection of visually normal tissue adjacent to neoplastic lesions often reveals multiple foci of cellular abnormalities. This suggests the presence of a regional carcinogenic signal that spreads oncogenic transformation and field cancerization. We observed an abundance of mutagenic reactive oxygen species in the stroma of cryosectioned patient tumor biopsies, indicative of extratumoral oxidative stress. Diffusible hydrogen peroxide (H2O2) was elevated in the conditioned medium of cultured skin epithelia at various stages of oncogenic transformation, and H2O2 production increased with greater tumor-forming and metastatic capacity of the studied cell lines...
January 19, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28102072/ultrafast-dischargeable-limn-sub-2-sub-o-sub-4-sub-thin-film-electrodes-with-pseudocapacitive-properties-for-microbatteries
#2
Marcus Fehse, Rafael Trocoli, Edgar Ventosa, Elba Hernandez, Alfonso Sepulveda, Alex Morata, Albert Tarancón
LiMn<sub>2</sub>O<sub>4</sub> (LMO) thin films are deposited on Si-based substrates with Pt current collector via combinatorial pulsed laser deposition technique. The LMO thin films feature unique kinetics yielding to outstanding electrochemical cycling performance in aqueous environment. At extremely high current densities of up to 1880 μAcm<sup>-2</sup> (≈ 348 C) a reversible capacity of 2.6 μAhcm<sup>-2<\sup> is reached. Furthermore the electrochemical cycling remains very stable for over 3500 cycles with remarkable capacity retention of 99...
January 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28100824/asthma-copd-overlap-syndrome-showed-more-exacerbations-however-lower-mortality-than-copd
#3
J-W Bai, B Mao, W-L Yang, S Liang, H-W Lu, J-F Xu
BACKGROUND: Asthma-chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS) is a new determinate syndrome whose exact characteristics remain unclear. AIM: The objective of this study is to find more difference between ACOS and COPD. DESIGN: A retrospective study of ACOS and COPD in Chinese. METHODS: Data from 65 patients with ACOS and 65 patients with COPD were retrospectively collected and analyzed. The basis of this study was to compare the two groups while ruling out differences in age, sex and smoking history...
January 18, 2017: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/28099321/preoxygenation-physiologic-basis-benefits-and-potential-risks
#4
Usharani Nimmagadda, M Ramez Salem, George J Crystal
Preoxygenation before anesthetic induction and tracheal intubation is a widely accepted maneuver, designed to increase the body oxygen stores and thereby delay the onset of arterial hemoglobin desaturation during apnea. Because difficulties with ventilation and intubation are unpredictable, the need for preoxygenation is desirable in all patients. During emergence from anesthesia, residual effects of anesthetics and inadequate reversal of neuromuscular blockade can lead to hypoventilation, hypoxemia, and loss of airway patency...
February 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28098442/a-nasicon-type-mg0-5ti2-po4-3-negative-electrode-material-exhibits-different-electrochemical-energy-storage-mechanisms-in-na-ion-and-li-ion-batteries
#5
Yingying Zhao, Zhixuan Wei, Qiang Pang, Yingjin Wei, Yongmao Cai, Qiang Fu, Fei Du, Angelina Sarapulova, Helmut Ehrenberg, Bingbing Liu, Gang Chen
A Carbon-coated Mg0.5Ti2(PO4)3 polyanion material was prepared by the sol-gel method and then studied as the negative electrode materials for lithium-ion and sodium-ion batteries. The material showed a specific capacity of 268.6 mAh g-1 in the voltage window of 0.01-3.0 V vs. Na+/Na0. Due to the fast diffusion of Na+ in the NASICON framework, the material exhibited superior rate capability with a specific capacity of 94.4 mAh g-1 at a current density of 5A g-1. Additionally, 99.1 % capacity retention was achieved after 300 cycles, demonstrating excellent cycle stability...
January 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28095268/impact-of-increasing-age-on-cause-specific-mortality-and-morbidity-in-patients-with-stage-i-non-small-cell-lung-cancer-a-competing-risks-analysis
#6
Takashi Eguchi, Sarina Bains, Ming-Ching Lee, Kay See Tan, Boris Hristov, Daniel H Buitrago, Manjit S Bains, Robert J Downey, James Huang, James M Isbell, Bernard J Park, Valerie W Rusch, David R Jones, Prasad S Adusumilli
Purpose To perform competing risks analysis and determine short- and long-term cancer- and noncancer-specific mortality and morbidity in patients who had undergone resection for stage I non-small-cell lung cancer (NSCLC). Patients and Methods Of 5,371 consecutive patients who had undergone curative-intent resection of primary lung cancer at our institution (2000 to 2011), 2,186 with pathologic stage I NSCLC were included in the analysis. All preoperative clinical variables known to affect outcomes were included in the analysis, specifically, Charlson comorbidity index, predicted postoperative (ppo) diffusing capacity of the lung for carbon monoxide, and ppo forced expiratory volume in 1 second...
January 20, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28094508/multiangular-rod-shaped-na0-44mno2-as-cathode-materials-with-high-rate-and-long-life-for-sodium-ion-batteries
#7
Qiannan Liu, Zhe Hu, Mingzhe Chen, Qinfen Gu, Yuhai Dou, Ziqi Sun, Shulei Chou, Shi Xue Dou
The tunnel-structured Na0.44MnO2 is considered as a promising cathode material for sodium-ion batteries because of its unique three-dimensional crystal structure. Multiangular rod-shaped Na0.44MnO2 have been first synthesized via a reverse microemulsion method and investigated as high-rate and long-life cathode materials for Na-ion batteries. The microstructure and composition of prepared Na0.44MnO2 is highly related to the sintering temperature. This structure with suitable size increases the contact area between the material and the electrolyte and guarantees fast sodium-ion diffusion...
January 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28090297/exhaled-nitric-oxide-in-pulmonary-arterial-hypertension-associated-with-systemic-sclerosis
#8
Zeling Cao, Stephen C Mathai, Laura K Hummers, Ami A Shah, Fredrick M Wigley, Noah Lechtzin, Paul M Hassoun, Reda E Girgis
The fractional exhaled concentration of nitric oxide (FENO) has been shown to be reduced in idiopathic pulmonary arterial hypertension (PAH) but has not been adequately studied in PAH associated with systemic sclerosis (SSc). We measured FENO at an expiratory flow rate of 50 mL/s in 21 treatment-naive patients with SSc-associated PAH (SSc-PAH), 94 subjects with SSc without pulmonary involvement, and 84 healthy volunteers. Measurements of FENO at additional flow rates of 100, 150, and 250 mL/s were obtained to derive the flow-independent nitric oxide exchange parameters of maximal airway flux (J'awNO) and steady-state alveolar concentration (CANO)...
December 2016: Pulmonary Circulation
https://www.readbyqxmd.com/read/28089974/cardiopulmonary-disease-development-in-anti-rna-polymerase-iii-positive-systemic-sclerosis-comparative-analyses-from-an-unselected-prospective-patient-cohort
#9
Anna-Maria Hoffmann-Vold, Øyvind Midtvedt, Anders H Tennøe, Torhild Garen, May Brit Lund, Trond M Aaløkken, Arne K Andreassen, Fadi Elhage, Cathrine Brunborg, Eli Taraldsrud, Øyvind Molberg
OBJECTIVE: Extensive skin disease and renal crisis are hallmarks of anti-RNA polymerase III (RNAP)-positive systemic sclerosis (SSc), while lung and heart involvement data are conflicting. Here, the aims were to perform time-course analyses of interstitial lung disease (ILD) and pulmonary hypertension (PH) in the RNAP subset of a prospective unselected SSc cohort and to use the other autoantibody subsets as comparators. METHODS: The study cohort included 279 patients with SSc from the observational Oslo University Hospital cohort with complete data on (1) SSc-related autoantibodies, (2) paired, serial analyses of lung function and fibrosis by computed tomography, and (3) PH verified by right heart catheterization...
January 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28089275/microfluidic-membrane-suppressor-module-design-and-evaluation-for-capillary-ion-chromatography
#10
Sam Wouters, Cees Bruggink, Yury Agroskin, Christopher Pohl, Sebastiaan Eeltink
A microfluidic ion-suppression module for use in ion-exchange chromatography has been developed and evaluated. The device consists of an ion-exchange membrane clamped between two polymer chips featuring a 200×100μm (width×depth) eluent channel (l=60mm), and a 300×150μm regenerant channel (60mm), respectively. The suppression efficacy using a Nafion membrane was compared with that of a styrene-sulfonate grafted fluorinated ethylene propylene (FEP) membrane. The latter was found to outperform Nafion in terms of lowest attainable background signal (suppression efficacy) and dynamic suppression range...
December 29, 2016: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28088638/the-dlno-dlco-ratio-physiological-significance-and-clinical-implications
#11
J M B Hughes, A T Dinh-Xuan
DLNO/DLCO directly measures the ratio of the diffusing capacities of the lung for nitric oxide (NO) and carbon monoxide (CO). In terms of the Roughton and Forster, 1957; equation, 1/DL=1/Dm+1/θVc, where Dm is the membrane (Dm) and θVc is the red cell component of the overall diffusing conductance (DL), DLNO mostly reflects the Dm component and DLCO the θVc red cell component. The DLNO/DLCO ratio is positively related to the DmCO/Vc ratio and the CO red cell resistance (1/θCOVc) as a percentage of the total resistance (1/DLCO), independent of the absolute values of DLNO or DLCO...
January 11, 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/28087341/lung-diffusing-capacity-in-sub-saharan-africans-versus-european-caucasians
#12
Bamodi Simaga, Kevin Forton, Yoshiki Motoji, Robert Naeije, Vitalie Faoro
Single breath measurements of lung diffusing capacity (DL) for carbon monoxide (CO) and nitric oxide (NO) were performed in age-, sex-, weight- and height-matched 32 Sub-Saharan Africans (13 women) and 32 Caucasian Europeans, and repeated in 14 of each group at 80% of maximum exercise capacity. In Africans versus Caucasians respectively, DLNO was 153±31 vs 176±38ml/mmHg/min at rest (P<0.001) and 210±48 vs 241±52ml/mmHg/min at exercise (P<0.01) while hemoglobin-adjusted DLCO was 29±6 vs 34±6ml/mmHg/min at rest (P<0...
January 10, 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/28086884/transfer-factor-for-carbon-monoxide-in-patients-with-copd-and-diabetes-results-from-the-german-cosyconet-cohort
#13
Kathrin Kahnert, Tanja Lucke, Frank Biertz, Andreas Lechner, Henrik Watz, Peter Alter, Robert Bals, Jürgen Behr, Rolf Holle, Rudolf M Huber, Stefan Karrasch, Beate Stubbe, Margarethe Wacker, Sandra Söhler, Emiel F M Wouters, Claus Vogelmeier, Rudolf A Jörres
BACKGROUND: An impairment of CO diffusing capacity has been shown in diabetic patients without lung disease. We analyzed how diffusing capacity in patients with COPD is affected by the concurrent diagnosis of diabetes. METHODS: Data from the initial visit of the German COPD cohort COSYCONET were used for analysis. 2575 patients with complete lung function data were included, among them 358 defined as diabetics with a reported physician diagnosis of diabetes and/or specific medication...
January 13, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28086844/are-risk-predicting-models-useful-for-estimating-survival-of-patients-with-rheumatoid-arthritis-associated-interstitial-lung-disease
#14
Hanna M Nurmi, Minna K Purokivi, Miia S Kärkkäinen, Hannu-Pekka Kettunen, Tuomas A Selander, Riitta L Kaarteenaho
BACKGROUND: Risk predicting models have been applied in idiopathic pulmonary fibrosis (IPF), but still not validated in patients with rheumatoid arthritis-associated interstitial lung disease (RA-ILD). The purpose of this study was to test the suitability of three prediction models as well as individual lung function and demographic factors for evaluating the prognosis of RA-ILD patients. METHODS: Clinical and radiological data of 59 RA-ILD patients was re-assessed...
January 13, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/28081365/visualizing-arsenate-reactions-and-encapsulation-in-a-single-zero-valent-iron-nanoparticle
#15
Lan Ling, Wei-Xian Zhang
A nanostructure-based mechanism is presented on the enrichment, separation and immobilization of arsenic with nanoscale Zero-Valent Iron (nZVI). The As-Fe reactions are studied with Spherical Aberration Corrected Scanning Transmission Electron Microscopy (Cs-STEM). Near atomic-resolution (<1 nm3) electron tomography discovers a thin continuous layer (23±3 Å) of elemental arsenic sandwiched between the iron oxide shell and the zero-valent iron core. This points to a unique mechanism of nano-encapsulation and proves that the outer layer, especially the Fe(0)/oxide interface is the edge of the As-Fe reactions...
January 12, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28081341/association-of-neutrophil-lymphocyte-ratio-with-the-degree-ofinterstitial-lung-disease-in-systemic-sclerosis
#16
Nurhan Atilla, Gözde Yıldırım Çetin, Ayşe Balkarlı
BACKGROUND/AIM: Determining the severity of systemic sclerosis related interstitial lung disease (SSc-ILD) is based on clinical and radiological findings, inflammation marker levels, and carbon monoxide diffusing capacity of the lung (DLCO). Recently studies are ongoing for objective and easy markers. Neutrophil/lymphocyte ratio (NLR) is shown to be a good marker for inflammation in recent clinical trials. In this study, we aimed to identify the possible relationship between NLR and carbon monoxide transfer coefficient (KCO) of SSc-ILD patients...
December 20, 2016: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28081015/the-prospects-of-phosphorene-as-an-anode-material-for-high-performance-lithium-ion-batteries-a-fundamental-study
#17
Congyan Zhang, Ming Yu, George Anderson, Ruchira Ravinath Dharmasena, Gamini Sumanasekera
To completely understand lithium adsorption, diffusion, and capacity on the surface of phosphorene and, therefore, the prospects of phosphorene as an anode material for high-performance lithium-ion batteries (LIBs), we carried out density-functional-theory calculations and studied the lithium adsorption energy landscape, the lithium diffusion mobility, the lithium intercalation, and the lithium capacity of phosphorene. We also carried out, for the very first time, experimental measurement of the lithium capacity of phosphorene...
January 12, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28076952/compactness-of-the-lithium-peroxide-thin-film-formed-in-li-o2-batteries-and-its-link-to-the-charge-transport-mechanism-insights-from-stochastic-simulations
#18
Yinghui Yin, Ruijie Zhao, Yue Deng, Alejandro A Franco
We simulated the discharge process of Li-O2 batteries and the growth of Li2O2 thin films at the mesoscale with a novel kinetic Monte Carlo model, which combined a stochastic description of mass transport and detailed elementary reaction kinetics. The simulation results show that the ordering of the Li2O2 thin film is determined by the interplay between diffusion and reaction kinetics. Due to the fast reaction kinetics on the catalyst, the Li2O2 formed in the presence of catalyst (cat-CNF) shows a low degree of ordering and is more likely to be amorphous...
January 19, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28075043/all-organic-rechargeable-battery-with-reversibility-supported-by-water-in-salt-electrolyte
#19
Xiaoli Dong, Hongchuan Yu, Yuanyuan Ma, Junwei Lucas Bao, Donald G Truhlar, Yonggang Wang, Yongyao Xia
Rechargeable batteries with organic electrodes are preferred to those with transition-metal-containing electrodes for their environmental friendliness and resource availability, but all such batteries reported to date are based on organic electrolytes, which raise concerns of safety and performance. Here we report an aqueous-electrolyte all-organic rechargeable battery with a maximum operating voltage of 2.1 V, in which polytriphenylamine (PTPAn) and 1,4,5,8-naphthalenetetracarboxylic dianhydride (NTCDA)-derived polyimide (PNTCDA) serve as cathode and anode material, respectively...
January 11, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28073275/highly-efficient-retention-of-polysulfides-in-sea-urchin-like-carbon-nanotube-nanopolyhedra-superstructures-as-cathode-material-for-ultralong-life-lithium-sulfur-batteries
#20
Tao Chen, Baorui Cheng, Guoyin Zhu, Renpeng Chen, Yi Hu, Lianbo Ma, Hongling Lv, Yanrong Wang, Jia Liang, Zuoxiu Tie, Zhong Jin, Jie Liu
Despite high theoretical energy density, the practical deployment of lithium-sulfur (Li-S) batteries is still not implemented because of the severe capacity decay caused by polysulfide shuttling and the poor rate capability induced by low electrical conductivity of sulfur. Herein, we report a novel sulfur host material based on "sea urchin"-like cobalt nanoparticle embedded and nitrogen-doped carbon nanotube/nanopolyhedra (Co-NCNT/NP) superstructures for Li-S batteries. The hierarchical micromesopores in Co-NCNT/NP can allow efficient impregnation of sulfur and block diffusion of soluble polysulfides by physical confinement, and the incorporation of embedded Co nanoparticles and nitrogen doping (∼4...
January 11, 2017: Nano Letters
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