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Asthma th1

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https://www.readbyqxmd.com/read/28993609/transcription-factor-foxo1-is-essential-for-il-9-induction-in-t-helper-cells
#1
Sakshi Malik, Srikanth Sadhu, Srikanth Elesela, Ramendra Pati Pandey, Amanpreet Singh Chawla, Deepak Sharma, Lipsa Panda, Deepak Rathore, Balram Ghosh, Vineet Ahuja, Amit Awasthi
Interleukin 9 (IL-9)-producing helper T (Th9) cells have a crucial function in allergic inflammation, autoimmunity, immunity to extracellular pathogens and anti-tumor immune responses. In addition to Th9, Th2, Th17 and Foxp3(+) regulatory T (Treg) cells produce IL-9. A transcription factor that is critical for IL-9 induction in Th2, Th9 and Th17 cells has not been identified. Here we show that the forkhead family transcription factor Foxo1 is required for IL-9 induction in Th9 and Th17 cells. We further show that inhibition of AKT enhances IL-9 induction in Th9 cells while it reciprocally regulates IL-9 and IL-17 in Th17 cells via Foxo1...
October 9, 2017: Nature Communications
https://www.readbyqxmd.com/read/28986735/no2-inhalation-enhances-asthma-susceptibility-in-a-rat-model
#2
Ming Han, Xiaotong Ji, Guangke Li, Nan Sang
Nitrogen dioxide (NO2) is a major air pollutant. Epidemiologic studies have found that NO2 exposure is associated with an increased risk of asthma. Nevertheless, the potential molecular mechanisms remain unclear. In this study, we investigated the effect of NO2 inhalation on the occurrence of allergic airway inflammation and its underlying mechanisms. Firstly, male Wistar rats were exposed to 2 and 5 mg/m(3) NO2 (28 days, 5 h/day). The results showed that NO2 exposure could induce pulmonary inflammatory response, mucus formation, and Th1/Th2 imbalance in the lung of normal rats, resulting in allergic asthma-like features...
October 7, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28966674/tlr4-antagonist-suppresses-airway-remodeling-in-asthma-by-inhibiting-the-t-helper-2-response
#3
Ming Li, Zhao-Ni Wang, Li-Fen Yang, Yan Yan, Liang-Ming Cai, Ya-Ting Li, Yong-Kang Qiao, Zhuang-Gui Chen
Airway remodeling is a hallmark of bronchial asthma. Our group has previously reported that the thymic stromal lymphopoietin (TSLP), an airway epithelial-derived cytokine, has a central role in the pathogenesis of airway remodeling, and that toll-like receptor (TLR) 4 signaling in epithelial cells may trigger T-helper 2 (Th2) immune responses by overexpression of TSLP. However, it is currently unclear whether TLR4 is a target in the treatment of airway remodeling in asthma. The present study established a house dust mite (HDM)-induced chronic asthmatic model in female BALB/c mice and treated the HDM-exposed mice with 3 mg/kg TAK242, as a TLR4 antagonist, 30 min prior to HDM challenge for up to 2 weeks...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28959849/-effects-and-mechanism-of-angelicae-sinensis-radix-on-th1-th2-and-th17-treg-in-mice-with-asthma-and-yin-deficiency-syndrome
#4
Ting-Ting Ma, Xing-Zhong Feng, Xue-Yan Wang
Angelicae Sinensis Radix, with nourishing Yin, promoting blood circulation, and moisturizing dryness functions, is commonly used in clinical medicine. In order to investigate the effects and mechanism of Angelica sinensis(AS) on Th1/Th2 and Th17/Treg in mice with asthma and Yin deficiency syndrome, asthmatic and Yin deficiency syndrome Balb/c mice models were established by injecting and inhaling ovalbumin(OVA) and thyroxin. The models were treated with dexamethasone(DXM), AS extract and AS extract+DXM, respectively...
February 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28939412/th1-signatures-are-present-in-the-lower-airways-of-children-with-severe-asthma-regardless-of-allergic-status
#5
Julia A Wisniewski, Lyndsey M Muehling, Jacob D Eccles, Brian J Capaldo, Rachana Agrawal, Debbie-Ann Shirley, James T Patrie, Lisa J Workman, Alexander J Schuyler, Monica G Lawrence, W Gerald Teague, Judith A Woodfolk
BACKGROUND: The pathogenesis of severe asthma in childhood remains poorly understood. OBJECTIVE: To construct the immunological landscape in the airways of children with severe asthma. METHODS: Comprehensive analysis of multiple cell types and mediators was performed by flow cytometry and multiplex assay using bronchoalveolar lavage (BAL) specimens (n=68) from 52 highly characterized allergic and non-allergic children (0.5-17 years) with severe treatment-refractory asthma...
September 19, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28889953/role-of-b-cells-in-t-helper-cell-responses-in-a-mouse-model-of-asthma
#6
Tomasz Piotr Wypych, Roberta Marzi, Gregory F Wu, Antonio Lanzavecchia, Federica Sallusto
BACKGROUND: The importance of B lymphocytes to present antigens for antibody production is well documented. In contrast, very little is known about their capacity to influence CD4(+) T cell activation during primary or secondary response to allergens. OBJECTIVE: Using mouse models of asthma, we investigated the role of B cells as antigen presenting cells in propagation and initiation of T helper cell responses. METHODS: Mice were immunized via intranasal route with house dust mite extract (HDM) derived from Dermatophagoides pteronyssinus...
September 7, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28869867/atopic-dermatitis-and-psoriasis-two-different-immune-diseases-or-one-spectrum
#7
REVIEW
Emma Guttman-Yassky, James G Krueger
Psoriasis and atopic dermatitis (AD) are common T-cell mediated inflammatory diseases of the skin that can be treated by specific cytokine antagonists or more broad immunosuppressive drugs. The diseases are similar in that epidermal keratinocytes respond to T-cell derived cytokines by altering growth and differentiation responses, accounting for major parts of the overall disease phenotype. When studied across European-American populations, psoriasis and AD display differing T-cell polarity and different arrays of cytokines...
September 1, 2017: Current Opinion in Immunology
https://www.readbyqxmd.com/read/28865412/association-between-4259-t-g-and-574-g-t-polymorphisms-of-tim-3-with-asthma-in-an-iranian-population
#8
Maryam Sadri, Mazdak Ganjalikhani-Hakemi, Peyman Akbari, Rasoul Salehi, Sedighe Rastaghi, Ramin Ghasemi, Rezvan Meshkat
T-cell immunoglobulin and mucin domain (TIM)-3 have been shown to negatively regulate Th1 cell-mediated immunity. Activation of TIM-3 by galectin-9 induces Th1 cell apoptosis, which may contribute to skewing of immune response towards Th2-dominant immunity. The aim of this study was to determine whether certain genetic variations of TIM-3 influence predisposition to asthma in a sample of Iranian population. This case-control study was conducted on 209 patients with asthma and 200 healthy controls. The +4259 T>G and -574 G>T polymorphisms were detected using polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) and amplification refractory mutation system-PCR(ARMS-PCR)...
August 2017: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/28863927/the-role-of-non-invasive-modalities-for-assessing-inflammation-in-patients-with-non-cystic-fibrosis-bronchiectasis
#9
Stamatoula Tsikrika, Katerina Dimakou, Andriana I Papaioannou, Georgios Hillas, Loukas Thanos, Kostantinos Kostikas, Stelios Loukides, Spyros Papiris, Nickolaos Koulouris, Petros Bakakos
INTRODUCTION: Bronchiectasis is a heterogeneous entity, taking into account clinical characteristics, inflammatory response, effectiveness of treatment and frequency of exacerbations. In stable state non-cystic fibrosis (non-CF) bronchiectasis, little is known about non-invasive techniques used for evaluating airway inflammation in obstructive airway diseases. OBJECTIVES: We sought to evaluate the associations between induced sputum and clinical/radiologic characteristics, and the differences between biomarkers expressing Th1 and Th2 response in patients with non-CF bronchiectasis and to compare our findings with a previously studied population of patients with asthma and COPD...
August 29, 2017: Cytokine
https://www.readbyqxmd.com/read/28804539/mir-371-mir-138-mir-544-mir-145-and-mir-214-could-modulate-th1-th2-balance-in-asthma-through-the-combinatorial-regulation-of-runx3
#10
Yu-Ying Qiu, Ying-Wei Zhang, Xiu-Fen Qian, Tao Bian
Asthma is tightly related to the imbalance of Th1/Th2 cells, and Runx3 plays a pivotal role in the differentiation of T helper cells. The present study aimed to investigate dysregulated microRNAs that may target Runx3 in CD4(+) T cells from asthmatic patients and reveal Runx3 function in Th1/Th2 balance regulation. We detected the levels of Th1- and Th2-related cytokines by ELISA and analyzed the differentiation marker gene of T helper cells by qRT-PCR. Results indicated that an imbalance of Th1/Th2 cells was present in our asthmatic subject...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28803184/association-of-asthma-with-rheumatoid-arthritis-a-population-based-case-control-study
#11
Youn Ho Sheen, Mary C Rolfes, Chung-Il Wi, Cindy S Crowson, Richard S Pendegraft, Katherine S King, Euijung Ryu, Young J Juhn
BACKGROUND: TH1 and TH2 cells have counterregulatory relationships. However, the relationship between asthma, a TH2-predominant condition, and risk of systemic inflammatory diseases such as rheumatoid arthritis (RA), a TH1 condition, is poorly understood. OBJECTIVE: We aimed to determine whether asthma was associated with increased risks of incident RA among adults. METHODS: We conducted a retrospective population-based case-control study that examined existing incident RA cases and controls matched by age, sex, and registration year from the general population in Olmsted County, Minnesota, between January 2002 and December 2007...
August 9, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28782757/osthole-treatment-ameliorates-th2-mediated-allergic-asthma-and-exerts-immunomodulatory-effects-on-dendritic-cell-maturation-and-function
#12
Chen-Yuan Chiang, Chen-Chen Lee, Chia-Kwung Fan, Huei-Mei Huang, Bor-Luen Chiang, Yueh-Lun Lee
Osthole, an active component of Chinese herbal medicines, reportedly possesses various pharmacological properties and has potential therapeutic applications. This study explored the anti-allergic effects of osthole in asthmatic mice and investigated the immunomodulatory actions of osthole on dendritic cells (DCs) and T cells. Herein, we show that oral administration of osthole to BALB/c mice after ovalbumin (OVA) sensitization ameliorated all of the cardinal features of T helper 2 (Th2)-mediated allergic asthma; namely, the production of OVA-specific immunoglobulin E, airway hyperresponsiveness, airway inflammation and the production of Th2-type cytokines including interleukin (IL)-4, IL-5 and IL-13...
August 7, 2017: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/28776450/pharmacological-modulation-of-reactive-oxygen-species-ros-improves-the-airway-hyperresponsiveness-by-shifting-the-th1-response-in-allergic-inflammation-induced-by-ovalbumin
#13
Renata Tiscoski Nesi, Marina Valente Barroso, Valdirene de Souza Muniz, Ana Carolina de Arantes, Marco Aurélio Martins, Lycia de Brito Gitirana, Josiane Sabbadini Neves, Cláudia Farias Benjamim, Manuella Lanzetti, Samuel Santos Valenca
Asthma is an allergic inflammation driven by the Th2 immune response with release of cytokines such as IL-4 and IL-13, which contribute to the airflow limitations and airway hyperresponsiveness (AHR). The involvement of oxidative stress in this process is well-established, but the specific role of the superoxide anion and nitric oxide in asthma are poorly understood. Thus, the aim of this study was to investigate the mechanisms underlying the superoxide anion/nitric oxide production and detoxification in a murine asthma model...
August 24, 2017: Free Radical Research
https://www.readbyqxmd.com/read/28769099/thermoneutral-housing-temperature-regulates-t-regulatory-cell-function-and-inhibits-ovabumin-induced-asthma-development-in-mice
#14
Wenjing Liao, Libo Zhou, Xiaolong Zhao, Lijuan Song, Yingshen Lu, Nanshan Zhong, Pingchang Yang, Baoqing Sun, Xiaowen Zhang
The change in ambient temperature is one of the risk factors for the aggravation of bronchial asthma (BA). Yet, whether the ambient temperature influences the immune functions associated with allergic asthma remains unknown. In this study, we treated asthmatic mice with standard temperature (ST, 20 °C) or thermoneutral temperature (TT, 30 °C). The results showed that the airway inflammatory cell counts in bronchoalveolar lavage fluid (BALF) and airway hyperresponsiveness (AHR) were significantly reduced in the mice treated with TT as compared with the mice treated with ST...
August 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28759187/a-chinese-herbal-medicine-modified-guomin-decoction-influences-the-differentiation-of-cd4-t-cell-subsets-in-ova-induced-asthmatic-mice
#15
Lilan Qin, Yuying Lan, Jian Sun, Beiqi Zhang, Peitao Xie, Jinghui Zheng, Shuran Ma
OBJECTIVE: Modified Guomin Decoction (MGD) is an effective Chinese herbal medicine for treatment of various allergic diseases, especially allergic asthma. Its water decoction is conventionally used for treatment of allergic bronchitis in China. Up to date, the underlying mechanisms of this herbal combination have not been fully investigated yet. METHODS: In the in vivo study, the mice were treated with Chicken egg ovalbumin (OVA) and aluminum hydroxide gel as the classic allergic asthma animal model...
July 2, 2017: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/28756630/dna-methylation-of-th2-lineage-determination-genes-at-birth-is-associated-with-allergic-outcomes-in-childhood
#16
S J Barton, S Ngo, P Costello, E Garratt, S El-Heis, E Antoun, R Clarke-Harris, R Murray, T Bhatt, G Burdge, C Cooper, H Inskip, E M van der Beek, A Sheppard, K M Godfrey, K A Lillycrop
BACKGROUND: There is now increasing evidence that asthma and atopy originate in part in utero, with disease risk being associated with the altered epigenetic regulation of genes. OBJECTIVE AND METHODS: To determine the relationship between variations in DNA methylation at birth and the development of allergic disease, we examined the methylation status of CpG loci within the promoter regions of Th1/2 lineage commitment genes (GATA3, IL-4, IL-4R, STAT4 and TBET) in umbilical cord DNA at birth in a cohort of infants from the Southampton Women's Survey (n = 696) who were later assessed for asthma, atopic eczema and atopy...
July 30, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28746467/tangeretin-has-anti-asthmatic-effects-via-regulating-pi3k-and-notch-signaling-and-modulating-th1-th2-th17-cytokine-balance-in-neonatal-asthmatic-mice
#17
L-L Liu, F-H Li, Y Zhang, X-F Zhang, J Yang
Asthma is a chronic allergic disease characterized by airway inflammation, airway hyper-responsiveness (AHR), and mucus hypersecretion. T-lymphocytes are involved in the pathogenesis of asthma, mediating airway inflammatory reactions by secreting cytokines. The phosphoinositide 3-kinase (PI3K) and Notch signaling pathways are associated with T cell signaling, proliferation, and differentiation, and are important in the progression of asthma. Thus, compounds that can modulate T cell proliferation and function may be of clinical value...
July 20, 2017: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/28737932/ins-and-outs-in-environmental-and-occupational-safety-studies-of-asthma-and-engineered-nanomaterials
#18
Marina A Dobrovolskaia, Michael R Shurin, Valerian E Kagan, Anna A Shvedova
According to the Centers for Disease Control and Prevention, approximately 25 million Americans suffer from asthma. The disease total annual cost is about $56 billion and includes both the direct and indirect costs of medications, hospital stays, missed work, and decreased productivity. Air pollution with xenobiotics, bacterial agents, and industrial nanomaterials, such as carbon nanotubes, contribute to the exacerbation of this condition and are a point of particular attention in environmental toxicology as well as in occupational health and safety research...
August 22, 2017: ACS Nano
https://www.readbyqxmd.com/read/28732646/phosphatase-wip1-controls-the-development-of-th9-cells-and-allergic-airway-inflammation
#19
Peng Wang, Huiting Su, Lianjun Zhang, Hui Chen, Xuelian Hu, Fan Yang, Jun Lu, Lianfeng Zhang, Yong Zhao
BACKGROUND: Allergic asthma is one of the most common diseases worldwide, resulting in a burden of diseases. No available therapeutic regimens can cure asthma so far. OBJECTIVE: To identify new molecular targets for Th9 cells-mediated allergic airway inflammation. METHODS: Wild-type p53-induced phosphatase 1 (Wip1) gene knockout mice, Wip1 inhibitor-treated mice and ovalbumin (OVA)-induced allergic airway inflammation mouse models were employed to characterize the roles of Wip1 in allergic airway inflammation...
July 18, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28729226/solanum-paniculatum-l-decreases-levels-of-inflammatory-cytokines-by-reducing-nfkb-tbet-and-gata3-gene-expression-in-vitro
#20
Raimon Rios, Hugo Bernardino Ferreira da Silva, Norma Vilany Queiroz Carneiro, Anaque de Oliveira Pires, Tamires Cana Brasil Carneiro, Ryan Dos Santos Costa, Cintia Rodrigues Marques, Marta Santos Serafim Machado, Eudes da Silva Velozo, Telma M G da Silva, Tania M S da Silva, Adilva de Souza Conceição, Neuza Maria Alcântara-Neves, Camila Alexandrina Figueiredo
ETHNOPHARMACOLOGICAL RELEVANCE: Solanum paniculatum L., popularly known as jurubeba, is a common subtropical plant from Brazil, Paraguay, Bolivia and Argentina, that is used in folk medicine for the treatment of anemia, gastrointestinal disorders and inflammatory conditions in general. In addition to that, an ethnobotanical survey in "Todos os Santos" Bay have pointed out S. paniculatum as an herb to treat asthma. Previous publications have shown that S. paniculatum possesses antibiotic, antioxidant and modulatory effects on gastric acid secretion; however, its anti-inflammatory potential remains unexplored...
July 18, 2017: Journal of Ethnopharmacology
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