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https://www.readbyqxmd.com/read/29452268/high-prevalence-of-liver-fibrosis-among-european-adults-with-unknown-liver-disease-a-population-based-study
#1
Llorenç Caballería, Guillem Pera, Ingrid Arteaga, Lluís Rodríguez, Alba Alumà, Rosa Ma Morillas, Napoleón de la Ossa, Alba Díaz, Carmen Expósito, Dolores Miranda, Carmen Sánchez, Rosa Ma Prats, Marta Urquizu, Angels Salgado, Magda Alemany, Alba Martinez, Irfan Majeed, Núria Fabrellas, Isabel Graupera, Ramón Planas, Isabel Ojanguren, Miquel Serra, Pere Torán, Juan Caballería, Pere Ginès
BACKGROUND AND AIMS: Liver fibrosis is the main determinant of long-term outcome in chronic liver diseases. Little is known about prevalence of liver fibrosis in general population. Aim of the study was to investigate the prevalence of liver fibrosis in general adult population with unknown liver disease. METHODS: Population-based, cross-sectional study, performed in Barcelona metropolitan area. Subjects aged 18-75yr were identified randomly from citizens included in primary health care registry...
February 13, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29451520/-hepatitis-c-virus-infection-from-clinical-guidelines-to-clinical-practice-and-personalization-of-cure
#2
Pierluigi Toniutto
Although clinical guidelines provide clear indications on the treatment of patients with chronic HCV related liver disease, there are still clinical situations in which clinicians experience and judgment remain essential in the proper patient management. These are mainly represented by antiviral therapy in patients with decompensated liver disease, especially if they are candidates for liver transplantation or with significant comorbidities and complex pharmacological therapies. Antiviral retreatment of patients who failed a regimen containing an NS5A protease inhibitor still appears to be a delicate context in which no solid recommendations are provided, especially in patients with HCV genotype 3 and decompensated cirrhosis...
January 2018: Recenti Progressi in Medicina
https://www.readbyqxmd.com/read/29451519/-hepatitis-c-virus-infections-is-it-only-e-liver-disease
#3
Salvatore Petta
Hepatitis C virus (HCV) infection is widely diffused in general population, and the likelihood that an infected individual is affected by other disesases is high. A lot of epidemiological and explicative studies, even if with different levels of evidence, reported a potential effect of HCV infection -by direct and indirect mechanisms- on the pathogenesis of extrahepatic comorbidities related to dysregulation of the immune system, or cardiometabolic comorbidities like diabetes, neuropsychiatric disorders, chronic kidney disease, cardiovascular alterations, etc...
January 2018: Recenti Progressi in Medicina
https://www.readbyqxmd.com/read/29451352/chronic-exposure-of-mice-to-low-doses-of-imazalil-induces-hepatotoxicity-at-the-physiological-biochemical-and-transcriptomic-levels
#4
Cuiyuan Jin, Ting Luo, Zhengwei Fu, Yuanxiang Jin
Imazalil (IMZ), which is a widely used fungicide, can accumulate in the body and threaten an animal's health. However, this fungicide has adverse effects on aquatic organisms and ultimately affects human health when it leaches into the environment. Our research tried to determine that if IMZ might cause liver damage and its potential to cause-related diseases. In this study, male adult C57BL/6 mice were exposed to 0.1, 0.5, or 2.5 mg/kg body weight IMZ in drinking water for 15 weeks. Then, we evaluated the liver damage at the physiological, biochemical, and transcriptome levels in mice after chronic IMZ exposure...
February 16, 2018: Environmental Toxicology
https://www.readbyqxmd.com/read/29451227/statural-growth-and-prevalence-of-endocrinopathies-in-relation-to-liver-iron-content-lic-in-adult-patients-with-beta-thalassemia-major-btm-and-sickle-cell-disease-scd
#5
Mohamed A Yassin, Ashraf T Soliman, Vincenzo De Sanctis, Mohammad Aj Abdula, Lubna M Riaz, Firdous F Ghori, Anil Yousaf, Abdulqadir J Nashwan, Sandara Abusamaan, Abbas Moustafa, Samah Kohla, Dina S Soliman
Despite regular blood transfusion and iron chelation therapy, growth impairment and pubertal delay are commonly seen in children and adolescents with transfusion-dependent Beta thalassaemia major (BTM) and sickle cell disease (SCD). We evaluated growth parameters and endocrine disorders in relation to the liver iron concentration (LIC) assessed by the Ferriscan® method in a cohort of adults with SCD (n =40) and BTM (n = 52) receiving blood transfusions and iron chelation therapy since early childhood. Before transfusion, hemoglobin concentration had not been less than 9 g/dl in the past 12 years; subcutaneous daily desferrioxamine was administered for all of them since early childhood (2- 5 years of age)...
February 16, 2018: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/29451181/the-use-of-nonselective-beta-blockers-is-a-risk-factor-for-portal-vein-thrombosis-in-cirrhotic-patients
#6
Rosa Zampino, Rita Lebano, Nicola Coppola, Margherita Macera, Anna Grandone, Luca Rinaldi, Ilario De Sio, Antonella Tufano, Gianfranca Stornaiuolo, Luigi E Adinolfi, Emanuele Durante-Mangoni, Gaeta G Battista, Alferio Niglio
Background/Aim: A reduction in portal vein inflow velocity seems to predispose to the emergence of portal vein thrombosis (PVT). Nonselective β-blockers (NSBBs), used to prevent variceal bleeding, may increase the development of PVT by reducing portal vein inflow velocity. In this retrospective case-control study, we evaluated the risk factors and clinical features of a first event of PVT in 130 cirrhotics, 19 (15%) with (PVT group) and 111 (85%) without PVT (non-PVT group). Patients and Methods: Patient evaluation and NNBB treatment were carried out according to the AASLD guidelines...
January 2018: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/29451010/assessment-of-mycoplasma-gallisepticum-vaccine-efficacy-in-a-co-infection-challenge-model-with-qx-like-infectious-bronchitis-virus
#7
Dauda G Bwala, Solomon Ponman, Neil Duncan, Daniel B R Wandrag, Celia Abolnik
Mycoplasma gallisepticum (MG) is the primary cause of chronic respiratory disease in poultry. We investigated the protective efficacy of the live attenuated ts-11 and 6/85 MG vaccines against a local MG strain, and in order to enhance symptoms and mimic a typical field situation, we co-infected birds with a virulent strain of QX-like infectious bronchitis virus (IBV). Both vaccines showed similar ability to protect infected chickens from clinical signs, although ts-11 performed slightly better. Despite the lower protection against clinical disease, 6/85-vaccinated birds had significantly (P≤0...
February 16, 2018: Avian Pathology: Journal of the W.V.P.A
https://www.readbyqxmd.com/read/29450824/solid-state-13-c-15-n-nmr-resonance-assignment-of-hepatitis-b-virus-core-protein
#8
Lauriane Lecoq, Shishan Wang, Thomas Wiegand, Stéphane Bressanelli, Michael Nassal, Beat H Meier, Anja Böckmann
Each year, nearly 900,000 deaths are due to serious liver diseases caused by chronic hepatitis B virus infection. The viral particle is composed of an outer envelope and an inner icosahedral nucleocapsid formed by multiple dimers of a ~ 20 kDa self-assembling core protein (Cp). Here we report the solid-state 13 C and 15 N resonance assignments of the assembly domain, Cp149, of the core protein in its capsid form. A secondary chemical shift analysis of the 140 visible residues suggests an overall alpha-helical three-dimensional fold matching that derived for Cp149 from the X-ray crystallography of the capsid, and from solution-state NMR of the Cp149 dimer...
February 16, 2018: Biomolecular NMR Assignments
https://www.readbyqxmd.com/read/29450209/creation-and-assessment-of-a-clinical-predictive-calculator-and-mortality-associated-with-candida-krusei-bloodstream-infections
#9
Ryan Kronen, Kevin Hsueh, Charlotte Lin, William G Powderly, Andrej Spec
Background: Candida krusei bloodstream infection (CK BSI) is associated with high mortality, but whether this is due to underlying comorbidities in affected patients or the organism itself is unknown. Identifying patient characteristics that are associated with CK BSI is crucial for clinical decision-making and prognosis. Methods: We conducted a retrospective analysis of hospitalized patients with Candida BSI at our institution between 2002 and 2015. Data were collected on demographics, comorbidities, medications, procedures, central lines, vital signs, and laboratory values...
February 2018: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/29449577/neutralization-of-il-15-abrogates-experimental-immune-mediated-cholangitis-in-diet-induced-obese-mice
#10
José L Reyes, Danielle T Vannan, Tina Vo, Aliya Gulamhusein, Paul L Beck, Raylene A Reimer, Bertus Eksteen
Obesity is a global epidemic affecting chronic inflammatory diseases. Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease that can occur as an extraintestinal manifestation of inflammatory bowel disease (IBD). Previously we reported that patients with PSC who are obese have a higher risk of advanced liver disease. Currently it is unknown how obesity accelerates or worsens PSC. We evaluated the progression of PSC in an antigen-driven cholangitis mouse model of diet-induced obesity. Obesity was induced in our murine model of immune-mediated cholangitis (OVAbil)...
February 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29448103/fgf-21-deficiency-slows-gastric-emptying-and-reduces-initial-blood-alcohol-concentration-in-mice-exposed-to-acute-alcohol-in-fasting-state
#11
Guicheng Wu, Yanlong Liu, Yunhuan Liu, Lihua Zhang, Haiyang Zhao, Liming Liu, Cuiqing Zhao, Wenke Feng
Excess alcohol consumption can lead to alcoholic liver disease. Fibroblast growth factor 21 (FGF21) is a metabolic regulator with multiple physiologic functions. Previous study demonstrated that FGF21 deficiency exacerbated alcohol-induced liver injury and exogenous FGF21 administration protected liver from chronic alcohol-induced injury. In this study, we aimed to explore the role of FGF21 in alcohol metabolism in mice. FGF21 knockout (KO) mice and the wild time (WT) control mice were divided into two groups and fasted for 24 h followed by a bonus of alcohol treatment at a dose of 5 g/kg body weight via gavage...
February 12, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29447944/activation-of-liver-x-receptor-%C3%AE-enhancing-neurogenesis-ameliorates-cognitive-impairment-induced-by-chronic-cerebral-hypoperfusion
#12
Ting Sun, Yu-Jiao Li, Qin-Qin Tian, Qi Wu, Dan Feng, Zhe Xue, Yan-Yan Guo, Le Yang, Kun Zhang, Ming-Gao Zhao, Yu-Mei Wu
Chronic cerebral hypoperfusion (CCH), a leading cause of various cerebrovascular diseases, leads to cognitive dysfunction due to neuron loss and impaired neurogenesis. Liver X receptors (LXRs), including LXRα and LXRβ isoforms, are crucial for cholesterol metabolism, synaptic plasticity as well as neurogenesis. However, it is not clear the potential roles of LXRs in the pathogenesis of cognitive impairment induced by CCH. In this study, we demonstrated that LXRβ expression decreased in hippocampus of CCH mice...
February 12, 2018: Experimental Neurology
https://www.readbyqxmd.com/read/29446799/autoimmune-hepatitis-in-children
#13
Saumya Pathak, Deepak Kamat
Autoimmune hepatitis (AIH) is an immune-mediated, inflammatory liver disease. Clinical presentation of AIH in children is highly variable. It can present acutely, chronically, or silently. There are two main types of AIH-type 1 and type 2, which are differentiated and defined by the presence of specific autoantibodies. AIH eventually progresses to cirrhosis when left untreated, and occasionally even with treatment. AIH must be suspected and excluded in all children presenting with signs of acute, prolonged, or severe liver disease...
February 1, 2018: Pediatric Annals
https://www.readbyqxmd.com/read/29446327/changes-in-life-expectancy-from-2006-to-2015-in-suzhou-east-china-contributions-of-age-and-cause-specific-mortality
#14
Chunyan Huang, Xinyuan Zhao, Yan Lu, Linchi Wang, Yihe Hu, Jun Zhang, Qiaoliang Huang, Gang Chen
This study was designed to estimate the contribution of age- and disease-specific mortality, particularly that attributable to chronic noncommunicable diseases and at-birth life expectancy (LE) in Suzhou, East China, between 2006 and 2015. In total, data on 427 290 deaths were analyzed. From 2006 to 2015, the at-birth LE increased from 78.92 years to 82.87 years in Suzhou. A decrease in all-cause age-specific death rates contributed to an increase of 1.98 years. The decreased death rates attributable to noncommunicable diseases including cerebrovascular diseases, cancer, heart disease, and respiratory diseases resulted in an increased LE of 1...
January 2018: Asia-Pacific Journal of Public Health
https://www.readbyqxmd.com/read/29445911/high-prevalence-of-hcv-gt4-related-tsh-abnormality-among-13402-egyptian-patients-treated-with-direct-acting-antiviral-therapy
#15
Rasha Eletreby, Mohamed Said, Zeinab Abdellatif, Yasmin Saad, Magdy ElSerafy, Hosam Dabes, Kadry ElSaeed, Yehia El-Shazly, Wahid Doss
BACKGROUND: HCV is associated with several extra hepatic diseases including thyroid dysfunction. This study aims at evaluating prevalence of thyroid dysfunction and its possible predictors in a large cohort of HCV GT4-infected patients, and the role of thyroid dysfunction as a predictor of response in the setting of direct acting antivirals (DAAs). METHODS: Patients registered on the web-based registry system to receive therapy for chronic HCV in Beheira governorate viral hepatitis specialized treatment center affiliated to the National committee for control of viral hepatitis (NCCVH), Ministry of health, Egypt in the period from January 2015 to October 2016...
February 14, 2018: Hepatology International
https://www.readbyqxmd.com/read/29445232/the-cerebellum-of-patients-with-steatohepatitis-shows-lymphocyte-infiltration-microglial-activation-and-loss-of-purkinje-and-granular-neurons
#16
Tiziano Balzano, Jerónimo Forteza, Pilar Molina, Juan Giner, Ana Monzó, Jennifer Sancho-Jiménez, Amparo Urios, Carmina Montoliu, Vicente Felipo
Peripheral inflammation contributes to minimal hepatic encephalopathy in chronic liver diseases, which could be mediated by neuroinflammation. Neuroinflammation in cerebellum of patients with chronic liver diseases has not been studied in detail. Our aim was to analyze in cerebellum of patients with different grades of liver disease, from mild steatohepatitis to cirrhosis and hepatic encephalopathy: (a) neuronal density in Purkinje and granular layers; (b) microglial activation; (c) astrocyte activation; (d) peripheral lymphocytes infiltration; (e) subtypes of lymphocytes infiltrated...
February 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29444947/hepatitis-c-virus-core-1-arfp-modulates-cyclin-d1-prb-pathway-and-promotes-carcinogenesis
#17
Savvina Moustafa, Ioannis Karakasiliotis, Penelope Mavromara
Viruses often encompass overlapping reading frames and unconventional translation mechanisms in order to maximize the output from a minimum genome and to orchestrate timely their gene expression. HCV possesses such an unconventional open reading frame (ORF) within the core-coding region, encoding an additional protein designated initially as ARFP or F or core+1. Two predominant isoforms of core+1/ARFP have been reported, core+1/L initiating from codon 26 and core+1/S initiating from codons 85/87 of the polyprotein coding region, respectively...
February 14, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29444700/pharmacotherapies-for-fatigue-in-chronic-liver-disease-cld-a-systematic-review-and-meta-analysis-protocol
#18
Andem Effiong, Prerna Kumari
BACKGROUND: This is the protocol for a systematic review (and meta-analysis) of an intervention. The primary objective of this systematic review will be to assess the benefits and harms of pharmacological therapies (pharmacotherapies) for the management of fatigue in adults with CLD of any etiology. The effects of pharmacological therapies on fatigue in CLD will be compared against those of placebo, no intervention, or non-pharmacological interventions. Specifically, this review will examine whether pharmacological therapies improve CLD-associated fatigue, and if they do, what key elements are associated with their effectiveness...
February 14, 2018: Systematic Reviews
https://www.readbyqxmd.com/read/29444657/understanding-the-rapid-increase-in-life-expectancy-in-shanghai-china-a-population-based-retrospective-analysis
#19
Hanyi Chen, Lipeng Hao, Chen Yang, Bei Yan, Qiao Sun, Lianghong Sun, Hua Chen, Yichen Chen
BACKGROUND: Life expectancy at birth (LE) is a comprehensive measure that accounts for age-specific death rates in a population. Shanghai has ranked first in LE in China mainland for decades. Understanding the reasons behind its sustained gain in LE provides a good reflection of many other cities in China. The aim of this study is intended to explore temporal trend in age- and cause-specific gains in LE in Shanghai and the probable reasons lay behind. METHODS: Joinpoint regression was applied to evaluate temporal trend in LE and the long time span was then divided accordingly...
February 14, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29444357/safety-of-direct-oral-anticoagulants-versus-warfarin-in-patients-with-chronic-liver-disease-and-atrial-fibrillation
#20
Pavel Goriacko, Keith T Veltri
BACKGROUND: A complication of chronic liver disease (CLD) is the abnormality of coagulation. In clinical practice, this increased risk of bleeding has not been identified as a protective factor against stroke or systemic embolism associated with atrial fibrillation (AF). The objective of this study was to assess the safety of direct oral anticoagulant (DOAC) agents versus warfarin in CLD patients with AF. METHODS: This was a retrospective cohort study of patients with CLD and AF initiated on oral anticoagulants...
February 14, 2018: European Journal of Haematology
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