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https://www.readbyqxmd.com/read/27936072/delonix-regia-leaf-extract-drle-a-potential-therapeutic-agent-for-cardioprotection
#1
Lung-Shuo Wang, Chun-Ting Lee, Wei-Lieh Su, Shih-Che Huang, Shu-Chi Wang
Delonix regia (Boj. Ex. Hook) is a flowering plant in the pea family found in tropical areas and its leaves are used informally to treat diseases in folk medicine. However, the cardioprotective effects in this plant are still unclear. In this study, we found that the Delonix regia leaf extract (DRLE) (400 mg/kg/d) can reduce the mortality rate in an isoproterenol (ISO)-induced heart injury and hypertrophy mouse model. Decreased serum levels of creatine phosphokinase, LDH, GOT, TNF-alpha and increased nitric oxide levels were found in DRLE-treated ISO-injured mice...
2016: PloS One
https://www.readbyqxmd.com/read/27936012/sugarcane-transcriptome-analysis-in-response-to-infection-caused-by-acidovorax-avenae-subsp-avenae
#2
Ailton B Santa Brigida, Cristian A Rojas, Clícia Grativol, Elvismary M de Armas, Júlio O P Entenza, Flávia Thiebaut, Marcelo de F Lima, Laurent Farrinelli, Adriana S Hemerly, Sérgio Lifschitz, Paulo C G Ferreira
Sugarcane is an important tropical crop mainly cultivated to produce ethanol and sugar. Crop productivity is negatively affected by Acidovorax avenae subsp avenae (Aaa), which causes the red stripe disease. Little is known about the molecular mechanisms triggered in response to the infection. We have investigated the molecular mechanism activated in sugarcane using a RNA-seq approach. We have produced a de novo transcriptome assembly (TR7) from sugarcane RNA-seq libraries submitted to drought and infection with Aaa...
2016: PloS One
https://www.readbyqxmd.com/read/27935960/hydrological-regime-and-water-shortage-as-drivers-of-the-seasonal-incidence-of-diarrheal-diseases-in-a-tropical-montane-environment
#3
Laurie Boithias, Marc Choisy, Noy Souliyaseng, Marine Jourdren, Fabrice Quet, Yves Buisson, Chanthamousone Thammahacksa, Norbert Silvera, Keooudone Latsachack, Oloth Sengtaheuanghoung, Alain Pierret, Emma Rochelle-Newall, Sylvia Becerra, Olivier Ribolzi
BACKGROUND: The global burden of diarrhea is a leading cause of morbidity and mortality worldwide. In montane areas of South-East Asia such as northern Laos, recent changes in land use have induced increased runoff, soil erosion and in-stream suspended sediment loads, and potential pathogen dissemination. To our knowledge, few studies have related diarrhea incidences to catchment scale hydrological factors such as river discharge, and loads of suspended sediment and of Fecal Indicator Bacteria (FIB) such as Escherichia coli, together with sociological factors such as hygiene practices...
December 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27935542/otolaryngological-manifestations-of-leishmaniosis
#4
Piotr Kurnatowski, Jakub Moroz
Travel to developing countries is associated with possibility to acquire different, also parasitic, diseases which have become a diagnostic and therapeutic problem. The ENT specialist is one of the medical officers who may make initial contact with a patient with a suspected parasitic disease. One of them is leishmaniosis: a parasitic disease classified as Neglected Tropical Diseases (NTD), which occurs in the tropics, subtropics and southern Europe. While asymptomatic invasion is observed in some cases, three forms of symptomatic leishmaniosis can be distinguished: cutaneous leishmaniosis (CL), visceral leishmaniosis (VL), and mucosal leishmaniosis (ML)...
October 31, 2016: Otolaryngologia Polska. the Polish Otolaryngology
https://www.readbyqxmd.com/read/27935474/a-pathology-of-progress-locating-the-historiography-of-cancer
#5
Agnes Arnold-Forster
Despite its prominent position in today's medical research, popular culture and everyday life, cancer's history is relatively unwritten. Compared to the other great 'plagues' - cholera, tuberculosis or tropical fevers, to name but a scant handful - cancer has few dedicated pages in the general surveys, and its specialists have largely failed to convince the broader community of medical historians - or indeed historians of anything at all - that histories of the disease can tell us fundamental things about the science and practice of medicine, both past and present...
December 2016: British Journal for the History of Science
https://www.readbyqxmd.com/read/27931200/amoebic-liver-abscess-an-unusual-cause-for-a-right-iliac-fossa-mass-a-case-report
#6
Vithiya Ratnasamy, Kumanan Thirunavukarasu, Kannathasan Selvam, Murugananthan Arumugam
BACKGROUND: Amoebic liver abscess is the most common extra intestinal manifestation of amoebiasis in tropical countries. It usually presents with right hypochondrial pain, fever and anorexia. Amoebic liver abscess has gained clinical significance due to the wide variety of clinical presentations which can cause diagnostic dilemmas and high mortality in untreated cases. CASE PRESENTATION: We report a case of a 63-year-old male with a history of anorexia for 3 weeks, fever for 4 days and examination findings of tender hepatomegaly with a liver span of 15 cm in the mid clavicular line and a firm irregular mass in the right iliac fossa...
December 8, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27931177/cholinesterase-inhibitory-anti-amyloidogenic-and-neuroprotective-effect-of-the-medicinal-plant-grewia-tiliaefolia-an-in-vitro-and-in-silico-study
#7
Dicson Sheeja Malar, Rajamohamed Beema Shafreen, Shunmugiah Karutha Pandian, Kasi Pandima Devi
CONTEXT: Grewia tiliaefolia Vahl. (Tiliaceae) is a sub-tropical plant used as an indigenous medicine in India. However, its efficacy has not been evaluated against Alzheimer's disease. OBJECTIVES: The objective of this study is to evaluate cholinesterase inhibitory, anti-aggregation and neuroprotective activity of G. tiliaefolia. MATERIALS AND METHOD: Grewia tiliaefolia leaves were collected from Eastern Ghats region, India, and subjected to successive extraction (petroleum ether, chloroform, ethyl acetate, methanol and water)...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/27929101/hookworm-infection
#8
Alex Loukas, Peter J Hotez, David Diemert, Maria Yazdanbakhsh, James S McCarthy, Rodrigo Correa-Oliveira, John Croese, Jeffrey M Bethony
Hookworms are soil-transmitted nematode parasites that can reside for many years in the small intestine of their human hosts; Necator americanus is the predominant infecting species. Adult worms feed on the blood of a host and can cause iron deficiency anaemia, especially in high-risk populations (children and women of childbearing age). Almost 500 million people in developing tropical countries are infected, and simulation models estimate that hookworm infection is responsible for >4 million disability-adjusted life years lost annually...
December 8, 2016: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/27928980/inside-doctor-livingstone-a-scottish-icon-s-encounter-with-tropical-disease
#9
Michael P Barrett, Federica Giordani
Dr David Livingstone died on May 1st 1873. He was 60 years old and had spent much of the previous 30 years walking across large stretches of Southern Africa, exploring the terrain he hoped could provide new environments in which Europeans and Africans could cohabit on equal terms and bring prosperity to a part of the world he saw ravaged by the slave trade. Just days before he died, he wrote in his journal about the permanent stream of blood that he was emitting related to haemorrhoids and the acute intestinal pain that had left him incapable of walking...
December 8, 2016: Parasitology
https://www.readbyqxmd.com/read/27928841/fusarium-species-causing-eumycetoma-report-of-two-cases-and-comprehensive-review-of-the-literature
#10
Abdullah M S Al-Hatmi, Alexandro Bonifaz, Andrés Tirado-Sánchez, Jacques F Meis, G Sybren de Hoog, Sarah A Ahmed
Recently, mycetoma was added to the World Health Organization's list of neglected tropical disease priorities. Fusarium as a genus has been reported to cause eumycetoma, but little is known about the species involved in this infection and their identification. In this study, molecular tools were applied to identify Fusarium agents from human eumycetoma cases. The partial translation elongation factor 1-alpha (TEF-1α) gene was used as diagnostic parameter. Two additional cases of eumycetoma, due to F. keratoplasticum and F...
December 7, 2016: Mycoses
https://www.readbyqxmd.com/read/27928082/incidence-and-clinical-outcome-of-acute-liver-failure-caused-by-dengue-in-a-hospital-for-tropical-diseases-thailand
#11
Khin Kye Mon, Apichart Nontprasert, Chatporn Kittitrakul, Pisit Tangkijvanich, Wattana Leowattana, Kittiyod Poovorawan
Acute liver failure is an atypical manifestation of dengue with a high mortality. We performed a retrospective cohort study at the Hospital for Tropical Diseases, Bangkok, Thailand. In total, 1,926 patients with serologically confirmed dengue were enrolled in the study from 2011 to 2015. Of these, six patients presented with acute liver failure, four died, and two survived. The incidence of dengue-associated acute liver failure was 0.31%. Dengue-associated acute liver failure was most common among young adults (median age, 29 years)...
December 7, 2016: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/27927991/diagnosis-and-treatment-of-leishmaniasis-clinical-practice-guidelines-by-the-infectious-diseases-society-of-america-idsa-and-the-american-society-of-tropical-medicine-and-hygiene-astmh
#12
Naomi Aronson, Barbara L Herwaldt, Michael Libman, Richard Pearson, Rogelio Lopez-Velez, Peter Weina, Edgar Carvalho, Moshe Ephros, Selma Jeronimo, Alan Magill
Diagnosis and treatment of Leishmaniasis: Clinical practice guidelines.
December 7, 2016: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/27921037/acute-kidney-injury-in-western-countries
#13
REVIEW
Josée Bouchard, Ravindra L Mehta
BACKGROUND: Acute kidney injury (AKI) is frequent and is associated with poor outcomes, including increased mortality, higher risk of chronic kidney disease, and prolonged hospital lengths of stay. The epidemiology of AKI mainly derives from studies performed in Western high-income countries. More limited data are available from Western low-income and middle-income countries (LMICs) located in Central and South America. SUMMARY: In this review, we summarize the most recent data on the epidemiology of AKI in Western countries, aiming to contrast results from industrialized high-income countries with LMICs...
October 2016: Kidney Diseases
https://www.readbyqxmd.com/read/27921036/acute-kidney-injury-in-asia
#14
REVIEW
Li Yang
BACKGROUND: Acute kidney injury (AKI) is a common disorder and is associated with a high morbidity and mortality worldwide. The diversity of the climate and of the socioeconomic and developmental status in Asia has a great influence on the etiology and presentation of AKI in different regions. In view of the International Society of Nephrology's 0by25 initiative, more and more attention has been paid to AKI in Asian countries. SUMMARY: In this review, we summarize the recent achievements with regard to the prevalence and clinical patterns of AKI in Asian countries...
October 2016: Kidney Diseases
https://www.readbyqxmd.com/read/27918573/benchmarking-the-cost-per-person-of-mass-treatment-for-selected-neglected-tropical-diseases-an-approach-based-on-literature-review-and-meta-regression-with-web-based-software-application
#15
Christopher Fitzpatrick, Fiona M Fleming, Matthew Madin-Warburton, Timm Schneider, Filip Meheus, Kingsley Asiedu, Anthony W Solomon, Antonio Montresor, Gautam Biswas
BACKGROUND: Advocacy around mass treatment for the elimination of selected Neglected Tropical Diseases (NTDs) has typically put the cost per person treated at less than US$ 0.50. Whilst useful for advocacy, the focus on a single number misrepresents the complexity of delivering "free" donated medicines to about a billion people across the world. We perform a literature review and meta-regression of the cost per person per round of mass treatment against NTDs. We develop a web-based software application (https://healthy...
December 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27917305/laboratory-diagnosis-for-outbreak-prone-infectious-diseases-after-typhoon-yolanda-haiyan-philippines
#16
Mariko Saito-Obata, Mayuko Saito, Titus C Tan, Inez Andrea P Medado, Clyde Dapat, Michiko Okamoto, Raita Tamaki, Rowena C Capistrano, Edelwisa Segubre-Mercado, Socorro P Lupisan, Hitoshi Oshitani
Typhoon Yolanda (Haiyan) hit the central part of the Philippines on November 8, 2013. To identify possible outbreaks of communicable diseases after the typhoon, nasopharyngeal swabs, stool and blood samples were collected from patients who visited the Eastern Visayas Regional Medical Center due to acute respiratory infection (ARI), acute gastroenteritis (AGE) or other febrile illness (OFI) including suspected dengue fever, between November 28, 2013 and February 5, 2014.   Methods: Samples were tested on-site for selected pathogens using rapid diagnostic tests...
October 21, 2016: PLoS Currents
https://www.readbyqxmd.com/read/27914949/anion-inhibition-profiles-of-the-%C3%AE-carbonic-anhydrase-from-the-pathogenic-bacterium-burkholderia-pseudomallei-responsible-of-melioidosis-and-highly-drug-resistant-to-common-antibiotics
#17
Sonia Del Prete, Daniela Vullo, Pietro Di Fonzo, Sameh M Osman, Zeid AlOthman, Claudiu T Supuran, Clemente Capasso
Burkholderia pseudomallei is a Gram-negative saprophytic bacterium responsible of melioidosis, an endemic disease of tropical and sub-tropical regions of the world. A recombinant γ-CA (BpsγCA) identified in the genome of this bacterium was cloned and purified. Its catalytic activity and anion inhibition profiles were investigated. The enzyme was an efficient catalyst for the CO2 hydration showing a kcat of 5.3×10(5)s(-1) and kcat/Km of 2.5×10(7)M(-1)×s(-1). The best BpsγCA inhibitors were sulfamide, sulfamic acid, phenylboronic acid and phenylarsonic acid, which showed KI in the range of 49-83μM (these inhibitors showed millimolar inhibition constant against hCA II), followed by diethyldithiocarbamate, selenate, tellurate, perrhenate, selenocyanate, trithiocarbonate, tetraborato, pyrophosphate, stannate, carbonate, bicarbonate, azide, cyanide, thiocyanate and cyanate with KIs in the range of 0...
November 14, 2016: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/27911051/sylvatic-transmission-of-trypanosoma-cruzi-among-domestic-and-wildlife-reservoirs-in-texas-usa-a-review-of-the-historical-literature
#18
REVIEW
S M Gunter, E L Brown, R Gorchakov, K O Murray, M N Garcia
Chagas disease (Trypanosoma cruzi infection) is one of the most important neglected tropical diseases affecting the Americas. The transmission dynamic of this parasite is a complicated process that involves three genera of Triatominae subfamily and over 100 known mammalian reservoirs composed of domestic, peridomestic and wildlife species. Understanding the complex relationship between vector species and mammalian hosts is important for preventing transmission to humans. We performed a historical literature review to assess the disease burden in the Texas wildlife and domestic animal population...
December 2, 2016: Zoonoses and Public Health
https://www.readbyqxmd.com/read/27907255/a-hyperspectral-image-can-predict-tropical-tree-growth-rates-in-single-species-stands
#19
T Trevor Caughlin, Sarah J Graves, Gregory P Asner, Michiel van Breugel, Jefferson S Hall, Roberta E Martin, Mark S Ashton, Stephanie A Bohlman
Remote sensing is increasingly needed to meet the critical demand for estimates of forest structure and composition at landscape to continental scales. Hyperspectral images can detect tree canopy properties, including species identity, leaf chemistry and disease. Tree growth rates are related to these measurable canopy properties but whether growth can be directly predicted from hyperspectral data remains unknown. We used a single hyperspectral image and light detection and ranging-derived elevation to predict growth rates for 20 tropical tree species planted in experimental plots...
December 2016: Ecological Applications: a Publication of the Ecological Society of America
https://www.readbyqxmd.com/read/27907248/mycobacterium-ulcerans-toxin-mycolactone-may-enhance-host-seeking-and-oviposition-behavior-by-aedes-aegypti-l-diptera-culicidae
#20
M L Sanders, H R Jordan, C Serewis-Pond, L Zheng, M E Benbow, P L Small, J K Tomberlin
The ecological functions of many toxins continue to remain unknown for those produced by environmental pathogens. Mycobacterium ulcerans, the causative agent of the neglected tropical disease, Buruli ulcer, produces a cytotoxic macrolide, mycolactone, whose function(s) in the environment remains elusive. Through a series of dual-choice behavior assays, we show that mycolactone may be an interkingdom cue for the yellow fever mosquito, Aedes aegypti, seeking blood-meals as well as oviposition sites. Results provide novel insight into the evolution between bacteria and potential vectors...
December 1, 2016: Environmental Microbiology
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