keyword
https://read.qxmd.com/read/38507007/methods-for-analysis-of-nanoparticle-immunosuppressive-properties
#21
JOURNAL ARTICLE
Edward Cedrone, Timothy M Potter, Barry W Neun, Marina A Dobrovolskaia
Adverse drug effects on immune system function represent a significant concern in the pharmaceutical industry, because 10-20% of drug withdrawal from the market is attributed to immunotoxicity. Immunosuppression is one such adverse effect. The traditional immune function test used to estimate materials' immunosuppression is T cell dependent antibody response (TDAR). This method involves a 28-day in vivo study evaluating the animal's antibody titer to a known antigen (Keyhole Limpet Hemocyanin; KLH) with and without challenge...
2024: Methods in Molecular Biology
https://read.qxmd.com/read/38500722/predictors-of-seasonal-influenza-and-covid-19-vaccination-coverage-among-adults-in-tennessee-during-the-covid-19-pandemic
#22
JOURNAL ARTICLE
J Cunningham-Erves, W George, M Sanderson, E Stewart, S W Jin, J Davis, H M Brandt
BACKGROUND: The COVID-19 pandemic has convoluted hesitancy toward vaccines, including the seasonal influenza (flu) vaccine. Because of COVID-19, the flu season has become more complicated; therefore, it is important to understand all the factors influencing the uptake of these vaccines to inform intervention targets. This article assesses factors related to the uptake of influenza and COVID-19 vaccines among adults in Tennessee. METHODS: A cross-sectional, secondary data analysis of 1,400 adults was conducted in Tennessee...
2024: Frontiers in Public Health
https://read.qxmd.com/read/38498876/clinical-outcomes-with-electronic-nudges-to-increase-influenza-vaccination-a-prespecified-analysis-of-a-nationwide-pragmatic-registry-based-randomized-implementation-trial
#23
JOURNAL ARTICLE
Niklas Dyrby Johansen, Muthiah Vaduganathan, Ankeet S Bhatt, Simin Gharib Lee, Daniel Modin, Brian L Claggett, Erica L Dueger, Sandrine Samson, Matthew M Loiacono, Rebecca C Harris, Lars Køber, Scott D Solomon, Pradeesh Sivapalan, Jens Ulrik Stæhr Jensen, Cyril Jean-Marie Martel, Tyra Grove Krause, Tor Biering-Sørensen
BACKGROUND: In the NUDGE-FLU (Nationwide Utilization of Danish Government Electronic letter system for increasing inFLUenza vaccine uptake) trial, electronic letters incorporating cardiovascular (CV) gain-framing and repeated messaging increased influenza vaccination by approximately 1 percentage point. OBJECTIVE: To evaluate the effects of the successful nudging interventions on downstream clinical outcomes. DESIGN: Prespecified exploratory analysis of a nationwide randomized implementation trial...
March 19, 2024: Annals of Internal Medicine
https://read.qxmd.com/read/38497899/iso-e-codelock-a-rebuilding-free-electrochemical-chip-with-a-customizable-decoding-probe-for-real-time-and-portable-pathogen-diagnostics
#24
JOURNAL ARTICLE
Yichen Liu, Yidan Tang, Yin Bao, Kaiwei Cai, Baiyang Lu, Rujian Zhao, Chunxu Yu, Yan Du, Bingling Li
In order to realize portable pathogen diagnostics with easier quantitation, digitization and integration, we develop a ready-to-use electrochemical sensing strategy (Iso-E-Codelock) for real-time detection of isothermal nucleic acid amplification. Bridged by a branch DNA as codelock, the isothermal amplicon is transduced into increased current of an electrochemical probe, holding multiple advantages of high sensitivity, high selectivity, signal-on response, "zero" background and one-pot operation. Through a self-designed portable instrument (BioAlex PHE-T), the detection can implement on a multichannel microchip and output real-time amplification curves just like an expensive commercial PCR machine...
March 18, 2024: Angewandte Chemie
https://read.qxmd.com/read/38497627/mesoporous-silica-nanoparticles-enhanced-microarray-technology-for-highly-sensitive-simultaneous-detection-of-multiplex-foodborne-pathogens
#25
JOURNAL ARTICLE
Timpika Hormsombut, Nutsara Mekjinda, Surachate Kalasin, Werasak Surareungchai, Patsamon Rijiravanich
Ensuring food safety is paramount for the food industry and global health concerns. In this study, we have developed a method for the detection of prevalent foodborne pathogenic bacteria, including Escherichia coli , Salmonella spp., Listeria spp., Shigella spp., Campylobacter spp., Clostridium spp., and Vibrio spp., utilizing antibody-aptamer arrays. To enhance the fluorescence signals on the microarray, the mesoporous silica nanoparticles (MSNs) conjugated with fluorescein, streptavidin, and seven detection antibodies-biotin were employed, forming fluorescein doped mesoporous silica nanoparticles conjugated with detection antibodies (MSNs-Flu-SA-Abs) complexes...
March 18, 2024: ACS Applied Bio Materials
https://read.qxmd.com/read/38497344/trigger-factors-in-patients-with-a-patent-foramen-ovale-associated-stroke-a-case-crossover-study
#26
JOURNAL ARTICLE
Maikel Immens, Merel Sanne Ekker, Esmee Verburgt, Jamie Verhoeven, Mijntje Schellekens, Nina Hilkens, Esther Boot, Mayte van Alebeek, Paul J A M Brouwers, Renate Arntz, Gert van Dijk, Rob Gons, Inge van Uden, Tom den Heijer, Paul L M de Kort, K de Laat, Anouk Gw van Norden, Sarah E Vermeer, Marian van Zagten, Robert J van Oostenbrugge, Marieke Wermer, Paul J Nederkoorn, Henk Kerkhoff, F Rooyer, Frank van Rooij, Ido van den Wijngaard, Catharina Klijn, Anil M Tuladhar, Tim Ten Cate, Frank-Erik de Leeuw
BACKGROUND: Patent foramen ovale (PFO) is a congenital anatomical variant which is associated with strokes in young adults. Contrary to vascular risk factors and atherosclerosis, a PFO is present from birth. However, it is completely unknown how an anatomical structure that is already present at birth in a large proportion of the population, can convert into a PFO that causes stroke in a few. Recent studies reported a significant association between certain trigger factors and ischemic stroke in young adults...
March 18, 2024: International Journal of Stroke: Official Journal of the International Stroke Society
https://read.qxmd.com/read/38496391/attitudes-toward-covid-19-vaccines-during-pregnancy-and-breastfeeding
#27
JOURNAL ARTICLE
Nesibe Simsekoglu, Enes Akyuz, Rabia Guven, Ozge Pasin
BACKGROUND: Although vaccination is one of the most effective means of controlling the spread of COVID-19, public concerns and indecision about vaccination still continue. Because pregnant and breastfeeding individuals are at high risk for severe outcomes in case of infections, determining their level of hesitation and attitude toward COVID-19 vaccines will guide the management of the disease. This study aimed to determine pregnant and breastfeeding women's levels of hesitation and attitude toward COVID-19 vaccines as well as their related factors...
2024: Frontiers in Public Health
https://read.qxmd.com/read/38494076/bendamustine-as-lymphodepletion-for-brexucabtagene-autoleucel-therapy-of-mantle-cell-lymphoma
#28
JOURNAL ARTICLE
Elise A Chong, Emeline R Chong, Dylan Therwhangher, Sunita D Nasta, Daniel J Landsburg, Stefan K Barta, Jakub Svoboda, James N Gerson, Guido Ghilardi, Luca Paruzzo, Joseph A Fraietta, Elizabeth Weber, Natalie Stefano, David L Porter, Noelle V Frey, Alfred L Garfall, Marco Ruella, Stephen J Schuster
BACKGROUND: Brexucabtagene autoleucel (brexu-cel) is an autologous CD19-directed chimeric antigen receptor (CAR) T-cell therapy approved for treatment of relapsed/refractory mantle cell lymphoma (MCL). During a fludarabine shortage, we used bendamustine as an alternative to standard cyclophosphamide/fludarabine (cy/flu) lymphodepletion (LD) prior to brexu-cel. OBJECTIVES: We assessed MCL patient outcomes as well as CAR T-cell expansion and persistence after brexu-cel following bendamustine or cy/flu LD at our center...
March 15, 2024: Transplantation and cellular therapy
https://read.qxmd.com/read/38492834/bycatch-and-pollution-are-the-main-threats-for-burmeister-s-porpoises-inhabiting-a-high-industrialized-bay-in-the-humboldt-current-system
#29
JOURNAL ARTICLE
Ana M García-Cegarra, Anna Hall, Emma Martínez-López
Pollution and bycatch are two of the main threats for cetaceans worldwide. These threats are exacerbated for nearshore species particularly for those in regions with intense industrial and fishing activities. Burmeister's porpoise is endemic to South America, has a Near Threatened conservation status because of long-term mortality in fisheries. Burmeister's porpoise occur in Mejillones Bay, northern Chile, a hot spot for heavy metals pollution from the mining industry and an intense industrial and artisanal purse-seine fishing area...
March 14, 2024: Environmental Research
https://read.qxmd.com/read/38491726/a-young-girl-with-acute-encephalopathy-who-presented-with-status-epilepticus-following-a-flu-like-illness
#30
JOURNAL ARTICLE
Noora Mohamed Saqr Aljalahma, Raafat Hammad Seroor Jadah
BACKGROUND Acute necrotizing encephalopathy of childhood (ANEC) is a rare form of acute encephalopathy in children that is characterized by rapid and progressive deterioration in the patient's clinical condition. Our aim in reporting the case is to highlight the importance of early diagnoses and aggressive early management of ANEC to achieve a better outcome. We report the case of a 5-year-old girl who presented with acute progressive encephalopathy with bilateral symmetrical thalamic involvement and brainstem lesion proceeded by a flu-like illness...
March 16, 2024: American Journal of Case Reports
https://read.qxmd.com/read/38491182/bird-flu-threat-disrupts-antarctic-penguin-studies
#31
Carissa Wong
No abstract text is available yet for this article.
March 15, 2024: Nature
https://read.qxmd.com/read/38491054/potential-of-pinus-eldarica-medw-tree-bark-for-biomonitoring-polycyclic-aromatic-hydrocarbons-in-ambient-air
#32
JOURNAL ARTICLE
Sohrab Hasheminejad, Hossein Moradi, Mohsen Soleimani
Urban trees' biomonitoring of pollutants such as polycyclic aromatic hydrocarbons (PAHs) yields pertinent and useful data for air pollution management. The aim of this study was to biomonitor PAHs in pine (Pinus eldarica Medw.) trees in the city of Isfahan and identify their sources. In total, 34 samples of outer bark of the trees were collected and their contents of 16 EPA PAHs were analyzed. With a median value of 136.3 ng/g, the total PAH contents in tree barks varied from 53.4 to 705.2 ng/g. The average values of the diagnostic ratios for Ant/(Ant + Phe), Flu/(Flu + Py), BaA/(BaA + Chr) and IP/(IP + BP) were 0...
March 15, 2024: Scientific Reports
https://read.qxmd.com/read/38489542/assessment-of-knowledge-and-biosecurity-practices-related-to-avian-influenza-among-poultry-workers-in-a-district-of-south-india
#33
JOURNAL ARTICLE
Chandan Mahadevan, Roopashree Mikkilineni, Navya Vyas, Nagappa Karabasanavar
CONTEXT: Avian influenza, commonly known as bird flu, is a contagious disease that affects both animals and humans, posing a significant threat to public health, animal welfare, and the economy. This study aims to evaluate the knowledge of avian influenza among poultry farmworkers and evaluate the biosecurity practices implemented on their farms. OBJECTIVE: The study's primary objective was to assess the knowledge regarding avian influenza among poultry farmworkers and the biosecurity practices they follow at the farm...
March 15, 2024: Journal of Public Health Management and Practice: JPHMP
https://read.qxmd.com/read/38488981/influenza-a-virus-pb1-f2-induces-affective-disorder-by-interfering-synaptic-plasticity-in-hippocampal-dentate-gyrus
#34
JOURNAL ARTICLE
Saiying Wang, Haijun Zhang, Rui Liu, Peijun Han, Qi Yang, Caiyan Cheng, Yue Chen, Zheng Rong, Chang Su, Fei Li, Gaofei Wei, Minggao Zhao, Le Yang
Influenza A virus (IAV) infection, which leads to millions of new cases annually, affects many tissues and organs of the human body, including the central nervous system (CNS). The incidence of affective disorders has increased after the flu pandemic; however, the potential mechanism has not been elucidated. PB1-F2, a key virulence molecule of various influenza virus strains, has been shown to inhibit cell proliferation and induce host inflammation; however, its role in the CNS has not been studied. In this study, we constructed and injected PB1-F2 into the hippocampal dentate gyrus (DG), a region closely associated with newborn neurons and neural development, to evaluate its influence on negative affective behaviors and learning performance in mice...
March 15, 2024: Molecular Neurobiology
https://read.qxmd.com/read/38487909/-relationship-between-the-lung-ultrasound-and-the-clinical-severity-of-the-patient-with-seasonal-flu
#35
JOURNAL ARTICLE
Lucile Dhuiege, Daniel De Backer, Simon Kalisz, Frédéric Cavallotto, Céline Rousseaux, Chloé Van Overstraeten, Pauline Lambert
INTRODUCTION: The seasonal flu is a very important reason for consultation every winter. Symptoms can quickly progress to severe pneumonia. Currently, few tools exist to assess the clinical severity of patients. The aim of this study is to demonstrate the role of lung ultrasound as a marker of severity in patients with influenza. METHODS: 79 patients who arrived at the emergency department with flu-like symptoms were included. A pulmonary ultrasound looking for an interstitial syndrome or consolidation was performed...
March 2024: Revue Médicale de Liège
https://read.qxmd.com/read/38486069/field-testing-the-transferability-of-behavioural-science-knowledge-on-promoting-vaccinations
#36
JOURNAL ARTICLE
Silvia Saccardo, Hengchen Dai, Maria A Han, Sitaram Vangala, Juyea Hoo, Jeffrey Fujimoto
As behavioural science is increasingly adopted by organizations, there is a growing need to assess the robustness and transferability of empirical findings. Here, we investigate the transferability of insights from various sources of behavioural science knowledge to field settings. Across three pre-registered randomized controlled trials (RCTs, N = 314,824) involving a critical policy domain-COVID-19 booster uptake-we field tested text-based interventions that either increased vaccinations in prior field work (RCT1, NCT05586204), elevated vaccination intentions in an online study (RCT2, NCT05586178) or were favoured by scientists and non-experts (RCT3, NCT05586165)...
March 14, 2024: Nature Human Behaviour
https://read.qxmd.com/read/38484707/gut-microbe-guides-alveolar-macrophages-to-fight-flu
#37
JOURNAL ARTICLE
Tao Wang, Yanling Wang, Yushi Yao
The intestinal microbiota is associated with defense against respiratory viral infections. In this issue of Cell Host & Microbe, Ngo and colleagues1 show that intestinal commensal segmented filamentous bacteria reprogram alveolar macrophages with improved influenza-viral-neutralizing and phagocytic functions while maintaining inflammatory anergy to better protect the lung.
March 13, 2024: Cell Host & Microbe
https://read.qxmd.com/read/38483213/phase-1-study-of-bortezomib-fludarabine-and-melphalan-with-or-without-total-marrow-irradiation-as-allogeneic-hematopoietic-stem-cell-transplant-conditioning-for-high-risk-or-relapsed-refractory-multiple-myeloma
#38
JOURNAL ARTICLE
Colton Ladbury, James Sanchez, Arnab Chowdhury, Joycelynne Palmer, An Liu, Anthony Stein, Myo Htut, Leonardo Farol, Ji-Lian Cai, George Somlo, Michael Rosenzweig, Jeffrey C Wong, Firoozeh Sahebi
OBJECTIVES: We conducted a phase 1 study of a conditioning regimen with or without total marrow irradiation (TMI) before allogeneic hematopoietic stem cell transplantation for patients with high-risk or refractory multiple myeloma. METHODS: Eighteen patients were enrolled on one of 2 strata. Patients with no prior radiation received TMI (900 cGy), fludarabine (FLU), and melphalan (MEL) conditioning, with bortezomib added in the second cohort (stratum I). Patients with prior radiation received FLU, MEL, and bortezomib, without TMI (stratum II)...
March 14, 2024: American Journal of Clinical Oncology
https://read.qxmd.com/read/38481147/remote-surveillance-and-detection-of-sars-cov-2-transmission-among-household-members-in-king-county-washington
#39
JOURNAL ARTICLE
Anne Emanuels, Amanda M Casto, Jessica Heimonen, Jessica O'Hanlon, Eric J Chow, Constance Ogokeh, Melissa A Rolfes, Peter D Han, James P Hughes, Timothy M Uyeki, Christian Frazar, Erin Chung, Lea M Starita, Janet A Englund, Helen Y Chu
BACKGROUND: Early during the COVID-19 pandemic, it was important to better understand transmission dynamics of SARS-CoV-2, the virus that causes COVID-19. Household contacts of infected individuals are particularly at risk for infection, but delays in contact tracing, delays in testing contacts, and isolation and quarantine posed challenges to accurately capturing secondary household cases. METHODS: In this study, 346 households in the Seattle region were provided with respiratory specimen collection kits and remotely monitored using web-based surveys for respiratory illness symptoms weekly between October 1, 2020, and June 20, 2021...
March 13, 2024: BMC Infectious Diseases
https://read.qxmd.com/read/38476365/seasonal-influenza-vaccines-differentially-activate-and-modulate-toll-like-receptor-expression-within-the-tumor-microenvironment
#40
JOURNAL ARTICLE
Kajal H Gupta, Eileena F Giurini, Andrew Zloza
Toll-like receptors (TLRs) are well-known for their role in cancer development as well as in directing anti-tumor immunity. Because TLRs have also been implicated in the innate recognition of the influenza virus, it was of great interest to investigate the potential TLRs' contribution to the reduction in tumor growth following intratumoral injection of an unadjuvanted influenza vaccine and the lack of antitumor response from an adjuvanted vaccine. In our previous publication, we showed that the unadjuvanted flu vaccine modulates TLR7 expression leading to anti-tumor response in a murine model of melanoma...
2024: Frontiers in Oncology
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