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https://www.readbyqxmd.com/read/29453856/defective-rna-sensing-by-rig-i-in-severe-influenza-virus-infection
#1
Sofie Eg Jørgensen, Mette Christiansen, Laura Barrett Ryø, Hans Henrik Gad, Jakob Gjedsted, Peter Staeheli, Jacob Giehm Mikkelsen, Merete Storgaard, Rune Hartmann, Trine Hyrup Mogensen
Influenza virus infection causes worldwide seasonal epidemics. Although influenza usually is a mild disease, a minority of patients experience very severe fulminating disease courses. Previous studies have demonstrated a role for type I interferon (IFN) in antiviral responses during influenza. However, IFN regulatory factor (IRF)7 deficiency is so far the only genetic cause of severe influenza described in humans. In this study we present a patient with severe influenza A virus (IAV) H1N1 infection during the 2009 Swine Flu pandemic...
February 17, 2018: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/29452853/the-impact-of-sex-steroid-agonists-and-antagonists-on-folliculogenesis-in-the-neonatal-porcine-ovary-via-cell-proliferation-and-apoptosis
#2
Katarzyna Knapczyk-Stwora, Malgorzata Grzesiak, Renata E Ciereszko, Elzbieta Czaja, Marek Koziorowski, Maria Slomczynska
The objective of the study was to examine the effects of androgen and estrogen agonists or antagonists on the follicle formation, ovarian cell proliferation and apoptosis as well as plasma steroid concentration in neonatal pigs. Piglets were injected with testosterone propionate (TP, 20 mg/kg bw), flutamide (FLU, 50 mg/kg bw), 4-tert-octylphenol (OP, 100 mg/kg bw), ICI 182,780 (ICI, 400 μg/kg bw), methoxychlor (MXC, 100 mg/kg bw) or corn oil (CTR, controls) between postnatal Days 1 and 10 (n = 4/group). Heart blood was collected and ovaries were excised from the 11-day-old piglets...
February 10, 2018: Theriogenology
https://www.readbyqxmd.com/read/29447989/aetiology-of-lower-respiratory-tract-infection-in-adults-in-primary-care-a-prospective-study-in-11-european-countries
#3
Margareta Ieven, Samuel Coenen, Katherine Loens, Christine Lammens, Frank Coenjaerts, Anouk Vanderstraeten, Birgitta Henriques-Normark, Derrick Crook, Kris Huygen, Chris C Butler, Theo Jm Verheij, Paul Little, Kalina Zlateva, Anton van Loon, Eric Cj Claas, Herman Goossens
OBJECTIVES: To describe the role of bacteria (including bacterial resistance), viruses (including those recently described), and mixed bacterial-viral infections in adults presenting to primary care with lower respiratory tract infection (LRTI). METHODS: We enrolled 3104 adults with LRTI, 141 (4.5%) of whom had community-acquired pneumonia (CAP), and 2985 matched controls in a prospective study in 16 primary care networks in Europe, and followed patients up at 28-35 days...
February 12, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29447623/community-health-workers-on-a-college-campus-effects-on-influenza-vaccination
#4
Jack J Huang, Maria Francesconi, Madeline H Cooper, Allyson Covello, Michelle Guo, Soheyla D Gharib
OBJECTIVE: To assess the impact of a campus community health worker program (HealthPALs) on student influenza vaccination. PARTICIPANTS: Undergraduate students at a northeastern US university (enrollment 6650), influenza seasons 2011-2012 through 2015-2016. METHODS: Study design: Difference-in-differences analysis of student vaccination at campus dormitory influenza clinics during intervention vs. baseline. INTERVENTION: In the first intervention year, HealthPALs conducted in-person peer outreach at several campus dormitory flu clinics...
February 15, 2018: Journal of American College Health: J of ACH
https://www.readbyqxmd.com/read/29447141/interim-estimates-of-2017-18-seasonal-influenza-vaccine-effectiveness-united-states-february-2018
#5
Brendan Flannery, Jessie R Chung, Edward A Belongia, Huong Q McLean, Manjusha Gaglani, Kempapura Murthy, Richard K Zimmerman, Mary Patricia Nowalk, Michael L Jackson, Lisa A Jackson, Arnold S Monto, Emily T Martin, Angie Foust, Wendy Sessions, LaShondra Berman, John R Barnes, Sarah Spencer, Alicia M Fry
In the United States, annual vaccination against seasonal influenza is recommended for all persons aged ≥6 months (1). During each influenza season since 2004-05, CDC has estimated the effectiveness of seasonal influenza vaccine to prevent laboratory-confirmed influenza associated with medically attended acute respiratory illness (ARI). This report uses data from 4,562 children and adults enrolled in the U.S. Influenza Vaccine Effectiveness Network (U.S. Flu VE Network) during November 2, 2017-February 3, 2018...
February 16, 2018: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29445061/the-prophylactic-effect-of-anti-influenza-agents-for-an-influenza-outbreak-in-a-university-hospital
#6
Mao Hagihara, Yukiko Kato, Ai Kurumiya, Tomoko Takahashi, Miki Sakata, Hideo Kato, Daisuke Sakanashi, Atsuko Yamada, Hiroyuki Suematsu, Jun Hirai, Naoya Nishiyama, Yusuke Koizumi, Yuka Yamagishi, Hiroshige Mikamo
Objective From November 24 to December 9, 2013, an outbreak of the influenza (flu) A (H3) virus occurred in a tertiary-care university hospital (1,014 beds). We herein report the prophylactic effect of anti-flu agents for controlling the flu outbreak. Methods We administered pre- or post-exposure prophylaxis with anti-flu agents in flu outbreak. To test the effectiveness of prophylaxis in a flu outbreak, we used the posterior mean of the reproductive value during the pre- and post-intervention period. We also simulated the probability distribution of new flu cases...
2018: Internal Medicine
https://www.readbyqxmd.com/read/29440875/experimental-and-molecular-modeling-approach-to-optimize-suitable-polymers-for-fabrication-of-stable-fluticasone-nanoparticles-with-enhanced-dissolution-and-antimicrobial-activity
#7
Shaimaa Ahmed, Thirumala Govender, Inamullah Khan, Nisar Ur Rehman, Waqar Ali, Syed Muhammad Hassan Shah, Shahzeb Khan, Zahid Hussain, Riaz Ullah, Mansour S Alsaid
Background and aim: The challenges with current antimicrobial drug therapy and resistance remain a significant global health threat. Nanodrug delivery systems are playing a crucial role in overcoming these challenges and open new avenues for effective antimicrobial therapy. While fluticasone (FLU), a poorly water-soluble corticosteroid, has been reported to have potential antimicrobial activity, approaches to optimize its dissolution profile and antimicrobial activity are lacking in the literature...
2018: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29439910/-analysis-of-the-refusal-of-the-flu-vaccination-regrivi-study
#8
S Méijome-Blanco, G González-Cristobo, A Á Regueiro-Martínez
INTRODUCTION: The objective of this study is to determine the reasons for refusing the flu vaccination in the Primary Care Health Centre of Vilanova de Arousa, Spain, as well as to evaluate the flu vaccination coverage after an educational intervention. MATERIAL AND METHODS: A quasi-experimental before and after study was conducted after an educational intervention on a total of 73 people that included those Primary Care Health Centre patients from Vilanova de Arousa who had refused the flu vaccination in 2014, and who did not meet the exclusion criteria (death during 2014 and 2015 campaigns, non-acceptance of participation, vaccine registration mistakes, contraindication or no indication for the vaccine, inability to contact)...
February 10, 2018: Semergen
https://www.readbyqxmd.com/read/29437709/prader-willi-syndrome-a-nest-for-premature-coronary-artery-disease
#9
Diogo Rodrigues Brás, Pedro Semedo, Bruno Cordeiro Piçarra, Renato Fernandes
Individuals affected by Prader-Willi syndrome (PWS) may show increased risk for coronary artery disease (CAD), which probably relates, at least, with high burden of cardiovascular risk factors.A 27-year-old man with PWS, obesity, hypertension, diabetes mellitus and dyslipidaemia attended the emergency department with complaints of flu-like condition and chest pain. The ECG revealed a mild ST-segment elevation in inferior leads, followed by positive myocardial necrosis biomarkers. Attending to the high cardiovascular risk profile, ST-segment elevation in inferior territory and wall motion abnormalities, a coronary angiogram was performed...
February 7, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29437672/gps-are-told-to-amend-flu-vaccine-orders-for-next-season
#10
Jacqui Wise
No abstract text is available yet for this article.
February 7, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29437649/margaret-mccartney-mandatory-flu-vaccination-won-t-fix-the-nhs
#11
Margaret McCartney
No abstract text is available yet for this article.
February 6, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29437304/risk-of-influenza-transmission-in-a-hospital-emergency-department-during-the-week-of-highest-incidence
#12
Miguel Esteve-Esteve, Daniel Bautista-Rentero, Vicente Zanón-Viguer
OBJECTIVES: To estimate the risk of influenza transmission in patients coming to a hospital emergency department during the week of highest incidence and to analyze factors associated with transmission. MATERIAL AND METHODS: Retrospective observational analysis of a cohort of patients treated in the emergency room during the 2014-2015 flu season. The following variables were collected from records: recorded influenza diagnosis, results of a rapid influenza confirmation test, point of exposure (emergency department, outpatient clinic, or the community), age, sex, flu vaccination or not, number of emergency visits, time spent in the waiting room, and total time in the hospital...
February 2018: Emergencias: Revista de la Sociedad Española de Medicina de Emergencias
https://www.readbyqxmd.com/read/29437303/flu-transmission-in-emergency-departments
#13
EDITORIAL
Antoni Trilla
No abstract text is available yet for this article.
February 2018: Emergencias: Revista de la Sociedad Española de Medicina de Emergencias
https://www.readbyqxmd.com/read/29437291/much-ado-about-flu-a-mixed-methods-study-of-parental-perceptions-trust-and-information-seeking-in-a-pandemic
#14
Catherine L King, Maria Y K Chow, Kerrie E Wiley, Julie Leask
BACKGROUND: Effective public health messaging is essential in both the planning phase and duration of a pandemic. OBJECTIVES: This study aimed to gain an understanding of parental information seeking, trusted sources and needs in relation to pandemic influenza A 2009 (pH1N1) to inform future policy planning and resource development. PATIENTS/METHODS: We conducted a mixed methods study; parents from 16 childcare centres in Sydney, Australia, were surveyed between 16 November and 9 December 2009 and interviews were conducted with participants from six childcare centres between June 2009 and May 2011...
February 13, 2018: Influenza and Other Respiratory Viruses
https://www.readbyqxmd.com/read/29436772/asthma-and-its-related-socioeconomic-factors-the-shiraz-adult-respiratory-disease-study-2015
#15
Seyed Masoom Masoompour, Hamideh Mahdaviazad, Seiyed Mohammad Ali Ghayumi
OBJECTIVE: This study aimed to explore the association between the prevalence of asthma and socio-economic factors using data from the Shiraz Adult Respiratory Disease Study, 2015(SARDS). METHODS: The SARDS was conducted from June to October 2015 among adult subjects of the general population of Shiraz, Iran. Current asthma was defined as the presence of at least one of the following factors in the preceding 12 months: 1) being awakened by an attack of shortness of breath, coughing, or chest tightness without any identifiable cause; 2) having an asthma attack; 3) currently using medication for asthma; or 4) having wheezing or whistling in the chest not associated with a cold or the flu...
February 13, 2018: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/29435283/targeted-immunotherapy-of-high-grade-cervical-intra-epithelial-neoplasia-expectations-from-clinical-trials
#16
Jean-Luc Brun, José Rajaonarison, Nicolas Nocart, Laura Hoarau, Stéphanie Brun, Isabelle Garrigue
Targeted immunotherapy of high-grade cervical intra-epithelial neoplasia (CIN) has been developed as an alternative to conization, to preserve future reproductive outcomes and avoid human papillomavirus (HPV) persistence. The objectives of the review are to present drugs according to their process of development and to examine their potential future use. A search for key words associated with CIN and targeted immunotherapy was carried out in the Cochrane library, Pubmed, Embase, and ClinicalTrials.gov from 1990 to 2016...
February 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29433695/zika-en-p%C3%A3-diatrie-que-retenir
#17
P Minodier
Zikavirus (ZV) is a flavivirus transmitted by Aedes mosquitoes' bites. Sexual transmission is possible. Common ZV infection is asymptomatic or associates flu-like signs. Guillain-Barre syndrome following ZV infection is rare. Foetal infection, during the first trimester of pregnancy especially, can lead to severe neurological troubles. Diagnosis relies on blood and urine RT-PCR during the acute phase, and serology later in the disease. ELISA assays false positives are reported among patients infected with another flavivirus, whereas sero-neutralization is more specific...
December 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/29433139/-a-health-promotion-campaign-to-improve-flu-vaccination-adherence-among-medical-residents-in-an-italian-teaching-hospital
#18
Andrea Barbara, Andrea Poscia, Concetta De Meo, Chiara De Waure, Vincenza Anzelmo, Paolo Emilio Santoro, Antonio Maruccia, Gabriele Giubbini, Alice Corsaro, Filippo Berloco, Gianfranco Damiani, Walter Ricciardi, Patrizia Laurenti
INTRODUCTION: In Italy annual flu vaccination for health care workers is recommended but coverage is usually unsatisfying. The compliance is even worse among medical residents (MRs) both in literature, both in our experience: in the flu season 2014/ 15 only 0.6% of MRs enrolled at the Università Cattolica del Sacro Cuore (UCSC) were vaccinated. For this reason, during the influenza season 2015/16, the Institute of Public Health of the UCSC, in collaboration with the Health Management of the "Agostino Gemelli" Teaching Hospital (FPG) and with the directive board of the Medical Specialization Schools (SSM) present at the University has tested several strategies to improve awareness and adherence to flu vaccination campaign by its staff...
September 2017: Igiene e Sanità Pubblica
https://www.readbyqxmd.com/read/29433137/-the-invisibles-project-meeting-and-collaboration-of-public-health-and-volunteering-the-influenza-vaccination-experience-to-promote-the-health-of-the-socially-vulnerable-and-economically-disadvantaged-population
#19
Loris Pagano, Caterina Pizzutelli, Maria Maddalena Matarazzo, Gaia Monteleone, Damiano Pizzuti
Migration and the current European socioeconomic conditions necessitate an evaluation/assessment, as detailed as possible, of the spread of seasonal infectious diseases in order to reduce inequalities in the healthcare system. The "Scuola di Formazione in Medicina Generale" of Lazio, in collaboration with the Community of Sant'Egidio of Rome, organized an influenza/flu vaccination campaign for homeless people, migrants and the poor in order to check their health conditions and prevent the spread of the most common infectious diseases...
September 2017: Igiene e Sanità Pubblica
https://www.readbyqxmd.com/read/29432302/allogeneic-matched-related-donor-bone-marrow-transplantation-for-pediatric-patients-with-severe-aplastic-anemia-using-low-dose-cyclophosphamide-atg-plus-fludarabine
#20
Chayamon Takpradit, Susan E Prockop, Nancy A Kernan, Andromachi Scaradavou, Kevin Curran, Julianne Ruggiero, Nicole Zakak, Richard J O'Reilly, Farid Boulad
BACKGROUND: The combination of cyclophosphamide (CY) and antithymocyte globulin (ATG) has been used as a standard conditioning regimen for matched related donor transplantation in patients with severe aplastic anemia. PROCEDURE: To decrease the regimen-related toxicity while maintaining appropriate engraftment and survival rates, fludarabine (FLU) was added to the regimen. Four pediatric patients received matched related donor bone marrow transplantation with CY (50 mg/kg×2) (instead of the 50 mg/kg×4 standard dosing), equine ATG (30 mg/kg×3), with the addition of FLU (30 mg/m×4)...
February 9, 2018: Journal of Pediatric Hematology/oncology
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