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https://www.readbyqxmd.com/read/28533104/seasonal-influenza-vaccine-uptake-among-people-with-disabilities-a-nationwide-population-study-of-disparities-by-type-of-disability-and-socioeconomic-status-in-france
#1
Aurélie Bocquier, Lisa Fressard, Alain Paraponaris, Bérengère Davin, Pierre Verger
People with disabilities use various preventive health services less frequently than others, notably because of a lower socioeconomic status (SES). We examined variations of seasonal influenza vaccine uptake according to type/severity of disability and SES. We analyzed (in 2016) data from the 2008 French national cross-sectional survey on health and disability (n=12,396 adults living in the community and belonging to target groups for seasonal influenza vaccination). We defined seasonal influenza vaccine uptake during the 2007-2008 season by the self-reporting of a flu shot between September 2007 and March 2008...
May 19, 2017: Preventive Medicine
https://www.readbyqxmd.com/read/28527874/pressor-support-during-a-jarisch-herxheimer-reaction-after-initiation-of-treatment-for-weil-s-disease
#2
Randi Connor-Schuler, Anee Khan, Nikhil Goyal, Erin Zimny
We present a case of Weil's disease complicated by a Jarisch-Herxheimer reaction (JHR) after initiation of antibiotics while in the emergency department requiring invasive monitoring and vasopressor support. The case is followed by a brief review of the JHR which is rarely observed with treatment of leptospirosis. A healthy 28-year-old female who recently returned from the Caribbean presented to the emergency department with flu-like symptoms. The patient appeared jaundiced with conjunctival suffusion and was ultimately treated with the appropriate antibiotics for leptospirosis in the ED...
April 27, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28524261/application-of-low-frequency-sonophoresis-and-reduction-of-antibiotics-in-the-aquatic-systems
#3
C Cobo Labarca, J Radinger, V Schöning, R Ariav, R Jung, K D Thompson, W Kloas, K Knopf
A major concern in aquaculture is the use of chemical therapeutics, such as antibiotics, because of their impact on the environment as well as on the fish product. As a potential tool for reducing antibiotic use, we tested the application of low-frequency ultrasound as a method for enhancing antibiotic uptake. Rainbow trout juveniles (Oncorhynchus mykiss) were exposed to two different concentrations of oxytetracycline (OTC), flumequine (FLU) and florfenicol (FLO), administered by bath after the application of ultrasound...
May 19, 2017: Journal of Fish Diseases
https://www.readbyqxmd.com/read/28524240/potential-serum-biomarkers-associated-with-mild-and-severe-leptospirosis-infection-a-cohort-study-in-the-malaysian-population
#4
Tan Xue Ting, Fairuz Binti Amran, Ravindran Thayan, Norazah Ahmad, Roslinda Jaafar, Rahimah Haron, Rafidah Abdullah, Sazwan Reezal Bin Shamsuddin, Nor Suhaila Binti Md Riffin, Puteri Shafinaz Abdul-Rahman
Leptospirosis is an emerging zoonotic infectious disease in Malaysia. The symptoms of leptospirosis vary from mild non-specific flu-like illness to a severe condition which is usually associated with serious complication and fatality. To study the protein expression profile of mild and severe leptospirosis, fifteen paired sera were collected from the patients who were mildly infected and following that progressed to severe stage. The proteome profiles of mild and severe cases were studied using 2DE analysis in combination with LC-MS/MS...
May 19, 2017: Electrophoresis
https://www.readbyqxmd.com/read/28521528/prevention-and-control-of-emergent-infectious-disease-with-high-specific-antigen-sensor
#5
Hongzhe Zhang, Shanshan Zhang, Nan Liu
This study aims to evaluate the application of a new type of high specificity antigen sensor in detecting the viruses in sudden infectious diseases. Influenza A (H1N1) virus immunosensor was used for the respective determination of the six kinds of antigens of H1N1, H3N2 viral protein, HA protein of H7N9, influenza B virus, adenovirus, and EV71 virus of same dilution degree on the Screen Printed Carbon Electrode (SPCE), so as to test the specificity of the detection method. In addition, various batches of chick embryo allantoic saliva dilution simulation samples were also detected on their recovery (accuracy), repeatability (precision), and stability...
May 18, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28520888/traffic-congestion-as-a-risk-factor-for-mortality-in-near-road-communities-a-case-crossover-study
#6
Meredith Pedde, Adam A Szpiro, Sara D Adar
Existing epidemiological research on traffic largely neglects localized fluctuations. We leveraged finely-resolved congestion data to investigate short-term associations with mortality in near-road communities. We identified all non-accidental, cardiovascular, cerebrovascular, and respiratory deaths (2009-2013) within 1 km of a Puget Sound highway. Using a case-crossover design, we examined the association between congestion 0-150, 151-300, and 301-1000 m upwind of a decedent's home and mortality, adjusting for meteorology, holidays, and flu...
May 18, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28514682/you-can-breathe-easy-ifn%C3%AE-handles-flu-without-triggering-a-damaging-inflammatory-response
#7
Bridget A Robinson, Timothy J Nice
Type III interferon (IFNλ) and type I IFN (IFNα/β) have overlapping antiviral activities in the lung. In this issue of Immunity, Galani et al. (2017) identify a critical early role for IFNλ, not shared by IFNα/β, in protection of the lung following influenza virus infection.
May 16, 2017: Immunity
https://www.readbyqxmd.com/read/28506756/-estimation-of-the-population-attributable-fraction-due-to-obesity-in-hospital-admissions-for-flu-valued-according-to-body-mass-index-bmi-and-cun-bae
#8
V Dávila-Batista, D Carriedo, F Díez, A Pueyo Bastida, B Martínez Durán, V Martin
INTRODUCTION: The obesity pandemic together with the influenza pandemic could lead to a significant burden of disease. The body mass index (BMI) does not discriminate obesity appropriately. The CUN-BAE has recently been used as an estimate of body fatness for Caucasians, including BMI, gender, and age. The aim of this study is to assess the population attributable fraction of hospital admissions due to influenza, due to the body fatness measured with the BMI, and the CUN-BAE. METHODS: A multicentre study was conducted using matched case-controls...
May 11, 2017: Semergen
https://www.readbyqxmd.com/read/28506389/proprotein-convertase-subtilisin-kexin-9%C3%A2-inhibition-in-patients-with-familial-hypercholesterolemia-initial-clinical-experience
#9
Annette M H Galema-Boers, Mattie J Lenzen, Eric J Sijbrands, Jeanine E Roeters van Lennep
BACKGROUND: Despite optimal lipid-lowering therapy, a minority of patients with familial hypercholesterolemia (FH) reach low-density lipoprotein cholesterol (LDL-c) target goals. In randomized trials, proprotein convertase subtilisin/kexin 9 (PCSK9) inhibitors led to impressive LDL-c reductions and a favorable safety profile. However, data about the efficacy and safety outside clinical trials are not available yet. OBJECTIVE: The purpose of the study is to describe efficacy and side effects of PCSK9 inhibitors in FH patients in clinical practice...
May 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28505784/spreading-dynamics-of-forget-remember-mechanism
#10
Shengfeng Deng, Wei Li
We study extensively the forget-remember mechanism (FRM) for message spreading, originally introduced in Eur. Phys. J. B 62, 247 (2008)EPJBFY1434-602810.1140/epjb/e2008-00139-4. The freedom of specifying forget-remember functions governing the FRM can enrich the spreading dynamics to a very large extent. The master equation is derived for describing the FRM dynamics. By applying the mean field techniques, we have shown how the steady states can be reached under certain conditions, which agrees well with the Monte Carlo simulations...
April 2017: Physical Review. E
https://www.readbyqxmd.com/read/28504057/molecular-dynamic-modeling-of-cyp51b-in-complex-with-azole-inhibitors
#11
Pan Gao, Yinglu Cui, Rongling Wu
Cytochrome P450 14α-sterol demethylase (CYP51), the key enzyme in sterol biosynthesis pathway, is an important target protein of cholesterol-lowering agents, antifungal drugs and herbicides. CYP51B enzyme is one of the CYP51 family members. In the present study, we have chosen four representative inhibitors of CYP51B: diniconazole(Din), fluconazole(Flu), tebuconazole(Teb), voriconazole(Vor) and launched to investigate the binding features of CYP51B-inhibitor and gating characteristics via molecular docking and molecular dynamics(MD) simulations...
May 13, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/28503216/public-knowledge-attitudes-and-practices-regarding-antibiotic-use-in-kosovo
#12
Drita Zajmi, Merita Berisha, Ilir Begolli, Rina Hoxha, Rukije Mehmeti, Gjyle Mulliqi-Osmani, Arsim Kurti, Afrim Loku, Lul Raka
BACKGROUND: Antimicrobial resistance is becoming a major public health challenge worldwide, caused primarily by the misuse of antibiotics. Antibiotic use is closely related to the knowledge, attitudes and behaviour of a population. OBJECTIVE: The objective of this study was to assess the level of knowledge, attitudes and practices about antibiotic use among the general public in Kosovo. METHODS: A cross-sectional face-to-face survey was carried out with a sample of 811 randomly selected Kosovo residents...
January 2017: Pharmacy Practice
https://www.readbyqxmd.com/read/28502747/chicken-egg-fetal-liver-dna-and-histopathologic-effects-of-structurally-diverse-carcinogens-and-non-carcinogens
#13
M J Iatropoulos, T Kobets, J-D Duan, K D Brunnemann, E Vock, U Deschl, G M Williams
Chicken egg fetal livers were evaluated for histopathological changes produced by four genotoxic hepatocarcinogens: 2-acetylaminofluorene (AAF), aflatoxin B1 (AFB1), benzo[a]pyrene (BaP), diethylnitrosamine (DEN); four structurally related non- or weakly- carcinogenic comparators: fluorene (FLU), aflatoxin B2 (AFB2), benzo[e]pyrene (BeP), N-nitrosodiethanolamine (NDELA); two epigenetic hepatocarcinogens: clofibric acid (CFA), phenobarbital (PB); and the non-carcinogen, D-mannitol (MAN). CFA, PB and MAN were also assessed for formation of DNA adducts using the (32)P nucleotide postlabeling (NPL) assay and for DNA breaks using the comet assay...
May 11, 2017: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
https://www.readbyqxmd.com/read/28491252/inhibitory-effects-of-carvacrol-on-the-expression-of-secreted-aspartyl-proteinases-1-3-in-fluconazole-resistant-candida-albicans-isolates
#14
Seyedeh Sedigheh Hosseini, Mohammad Hossein Yadegari, Masoumeh Rajabibazl, Ezzat Allah Ghaemi
BACKGROUND AND OBJECTIVES: Secreted Aspartyl Proteinase (SAP) is one of the main virulence factors in the pathogenesis of Candida. This enzyme is encoded by a family of at least ten genes. Among these genes, the role of SAP1-3 in mucosal infections is evident. This study aimed to investigate the expression of SAP1-3 genes of Candida albicans isolates after treatment with Echinophora platyloba extract, carvacrol and caspofungin drug. MATERIALS AND METHODS: Vaginal samples of 68 women with suspected vaginitis were obtained and cultured...
December 2016: Iranian Journal of Microbiology
https://www.readbyqxmd.com/read/28489781/clinical-characteristics-and-outcomes-of-patients-with-myocarditis-mimicking-st-segment-elevation-myocardial-infarction-analysis-of-a-case-series
#15
Shuang Wu, Yan-Min Yang, Jun Zhu, Huai-Bin Wan, Juan Wang, Han Zhang, Xing-Hui Shao
Acute myocarditis mimicking ST-segment elevation myocardial infarction (STEMI) is highly deceptive for an accurate diagnosis, and a systematic study is lacking with regard to the clinical features and prognosis of this distinct clinical entity.Patients with suspected STEMI and eventually diagnosed with myocarditis by cardiac magnetic resonance (CMR) from January 2012 to April 2016 at Fuwai Hospital were identified by reviewing medical records and electronic databases. Follow-up was conducted by clinical visits and phone contacts in a median duration of 17 months...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28487229/every-member-of-the-kingdom-animalia-is-a-potential-vector-of-human-pathogens
#16
LETTER
Seema Patel
Zoonotic diseases are a subset of infectious diseases, which account for enormous morbidity and mortality. Pathologies like malaria, rabies, Lyme disease, leptospirosis, avian flu etc. are microbe- and parasite-caused ailments, where the etiological agents are introduced into or on the human body via ticks, mosquitoes, birds, rodents, bats, and deer, among other members of kingdom Animalia. While some of the zoonotic diseases are well-investigated and caution taken against, a lot many are yet to be recognized...
May 6, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28484283/predicting-influenza-antigenicity-from-hemagglutintin-sequence-data-based-on-a-joint-random-forest-method
#17
Yuhua Yao, Xianhong Li, Bo Liao, Li Huang, Pingan He, Fayou Wang, Jiasheng Yang, Hailiang Sun, Yulong Zhao, Jialiang Yang
Timely identification of emerging antigenic variants is critical to influenza vaccine design. The accuracy of a sequence-based antigenic prediction method relies on the choice of amino acids substitution matrices. In this study, we first compared a comprehensive 95 substitution matrices reflecting various amino acids properties in predicting the antigenicity of influenza viruses by a random forest model. We then proposed a novel algorithm called joint random forest regression (JRFR) to jointly consider top substitution matrices...
May 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28482810/using-electronic-health-records-and-internet-search-information-for-accurate-influenza-forecasting
#18
Shihao Yang, Mauricio Santillana, John S Brownstein, Josh Gray, Stewart Richardson, S C Kou
BACKGROUND: Accurate influenza activity forecasting helps public health officials prepare and allocate resources for unusual influenza activity. Traditional flu surveillance systems, such as the Centers for Disease Control and Prevention's (CDC) influenza-like illnesses reports, lag behind real-time by one to 2 weeks, whereas information contained in cloud-based electronic health records (EHR) and in Internet users' search activity is typically available in near real-time. We present a method that combines the information from these two data sources with historical flu activity to produce national flu forecasts for the United States up to 4 weeks ahead of the publication of CDC's flu reports...
May 8, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28482582/core-shell-alginate-ghatti-gum-modified-montmorillonite-composite-matrices-for-stomach-specific-flurbiprofen-delivery
#19
Hriday Bera, Sohitha Reddy Ippagunta, Sanoj Kumar, Pavani Vangala
Novel alginate-arabic gum (AG) gel membrane coated alginate-ghatti gum (GG) modified montmorillonite (MMT) composite matrices were developed for intragastric flurbiprofen (FLU) delivery by combining floating and mucoadhesion mechanisms. The clay-biopolymer composite matrices containing FLU as core were accomplished by ionic-gelation technique. Effects of polymer-blend (alginate:GG) ratios and crosslinker (CaCl2) concentrations on drug entrapment efficiency (DEE, %) and cumulative drug release after 8h (Q8h, %) were studied to optimize the core matrices by a 3(2) factorial design...
July 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28477248/fluoxetine-an-antidepressant-drug-inhibited-cigarette-smoke-induced-pulmonary-inflammation-and-apoptosis-in-rats
#20
Zhiyong Cai, Jindi Liu, Hongliang Bian, Jinlan Cai, Qing Jin, Jijing Han
The present study was designed to evaluate the anti-inflammatory effect of fluoxetine (Flu) against cigarette smoke (CS)-induced chronic obstructive pulmonary disease (COPD) in rats. Forty male Sprague-Dawley (SD) rats were randomly assigned to five groups: control group, CS group, dexamethasone (2 mg/kg) group, and flu (2 mg/kg). H&E staining demonstrated that Flu inhibited CS-induced pathological injury. In addition, Flu could restore the levels of superoxide dismutase (SOD) and malondialdehyde (MDA) in serum...
May 5, 2017: Inflammation
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