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https://www.readbyqxmd.com/read/28811560/evidence-for-the-importance-of-post-transcriptional-regulatory-changes-in-ovarian-cancer-progression-and-the-contribution-of-mirnas
#1
Mengnan Zhang, Lilya V Matyunina, L DeEtte Walker, Weixuan Chen, Haopeng Xiao, Benedict B Benigno, Ronghu Wu, John F McDonald
High-throughput technologies have identified significant changes in patterns of mRNA expression over cancer development but the functional significance of these changes often rests upon the assumption that observed changes in levels of mRNA accurately reflect changes in levels of their encoded proteins. We systematically compared the expression of 4436 genes on the RNA and protein levels between discrete tumor samples collected from the ovary and from the omentum of the same OC patient. The overall correlation between global changes in levels of mRNA and their encoding proteins is low (r = 0...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28810875/role-of-iqgap3-in-metastasis-and-epithelial-mesenchymal-transition-in-human-hepatocellular-carcinoma
#2
Yongjie Shi, Nan Qin, Qiang Zhou, Yanqiu Chen, Sicong Huang, Bo Chen, Gang Shen, Hongyun Jia
BACKGROUND: Hepatocellular carcinoma (HCC) is one of the most lethal cancers worldwide owing to its high rates of metastasis and recurrence. The oncogene IQ motif-containing GTPase activating protein 3 (IQGAP3) is ubiquitously overexpressed in several human cancers, including liver, ovary, lung, large intestine, gastric, bone marrow, and breast malignancies and is involved in the invasion and metastasis of cancer cells. Therefore, we aimed to determine the biological role and molecular mechanism of IQGAP3 in HCC...
August 15, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28810294/-morphologic-features-of-fallopian-tubal-epithelium-in-pelvic-high-grade-serous-carcinoma
#3
R J Zhao, Y Y Wang, Z Li, K Y Wu, L F Kong, W X Zheng
Objective: To study the pathologic features of fallopian tubal epithelium in patients with pelvic high-grade serous carcinoma (HGSC), to investigate its role in pelvic serous carcinogenesis and to reclassify the primary site of HGSC based on recently proposed criteria. Methods: The fallopian tubes in 58 cases of pelvic HGSC (54 cases of ovarian primary, 3 cases of tubal primary, 1 case of peritoneum) and 25 cases of pelvic non-HGSC (5 cases of ovarian low-grade serous cancer, 9 cases of endometrioid cancer, and 11 cases of clear cell ovary carcinoma) were collected from June 2015 to December 2016, and serially examined under light microscope (SEE-FIM protocol)...
August 8, 2017: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/28808611/red-snappers-and-red-herrings-pelvic-tuberculosis-causing-elevated-ca-125-and-mimicking-advanced-ovarian-cancer-a-case-report-and-literature-review
#4
Johnnie Alphonse Yates, Olivia Ann Collis, Thanasak Sueblinvong, Tarquin Kamakana Collis
Female genital tuberculosis (FGTB) is a form of extra-pulmonary tuberculosis that has been primarily described in developing countries, where it is an important cause of infertility, ectopic pregnancy, and miscarriage. FGTB is rare in the United States and because its clinical presentation is non-specific and often insidious, FGTB may be misdiagnosed as a gynecologic malignancy or endometriosis. The tendency of tuberculosis to dramatically increase serum CA 125 levels contributes to the potential for FGTB to be mistaken for ovarian cancer in particular...
August 2017: Hawai'i Journal of Medicine & Public Health: a Journal of Asia Pacific Medicine & Public Health
https://www.readbyqxmd.com/read/28806987/a-prospective-study-to-evaluate-the-risk-malignancy-index-and-its-diagnostic-implication-in-patients-with-suspected-ovarian-mass
#5
Santosh Kumar Dora, Atal Bihari Dandapat, Benudhar Pande, Jatindra Prasad Hota
BACKGROUND: There is no universal screening method for discrimination between benign and malignant adnexal masses yet. Various authors have tried tumor markers, imaging studies, cytology but no one yet is a definite method for screening of cancer ovary, for which a combined diagnostic modality has come to practice in form of RMI. With this background we conducted our study "Evaluation of risk malignancy index and its diagnostic value in patients with adnexal masses". METHODS: The aim of the study was to determine the effectiveness of risk of malignancy index (RMI-3) in preoperative discrimination between benign and malignant masses and also to reveal the most suitable cut off value...
August 14, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28801321/massive-ascites-pelvic-mass-elevated-ca-125-and-weight-loss-think-outside-the-ovaries
#6
Jehan Khalid Mohammed Musleh, Mohammed Almulhem, Nourah Hasan Al Qahtani
A 44-year-old woman presented with 3 months' history of painless progressive abdominal distension and weight loss of more than 15 kg. Clinically a pelviabdominal mass with ascites was detected. CT scan of the pelvis and abdomen showed a subserosal leiomyoma with huge amount of ascites. Cancer Antigen (CA)-125 was 546 kU/L. Exploratory laparotomy with myomectomy was done and this was followed by dramatic improvement postoperatively.
August 11, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28801067/dna-methylation-in-cho-cells
#7
Anna Wippermann, Thomas Noll
Chinese hamster ovary (CHO) cells account for the production of the majority of biopharmaceutical molecules - however, the molecular basis for their versatile properties is not entirely understood yet and the underlying cellular processes need to be characterized in detail. One such process that is supposed to contribute significantly to CHO cell phenotype is methylation of DNA at cytosine residues. DNA methylation was shown to be involved in several central biological processes in humans and to contribute to diseases like cancer...
August 8, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/28800309/the-prognostic-role-of-preoperative-serum-ca125-levels-in-patients-with-advanced-endometrial-carcinoma
#8
Mitra Modarres-Gilani, Maryam Vaezi, Mamak Shariat, Narges Zamani, Roghaiyeh Nourizadeh
BACKGROUND: Lifetime risk of developing endometrial cancer is 2.17%. There is controversy regarding the predictive value of Cancer Antigen 125 (CA125) in endometrial cancer as well as the significance of its relationship with prognostic factors and appropriate cut-off value. OBJECTIVE: The aim of the present study was to investigate the prognostic role of CA125 in advanced endometrial carcinoma and determination of the appropriate cut-off value. METHODS: A sample of 91 patients was retrospectively selected from a population of 501 patients suffering from endometrial cancer during 1995 to 2015 in accordance with the inclusion criteria...
August 4, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/28796383/self-reported-transvaginal-ultrasound-visualization-of-normal-ovaries-in-postmenopausal-women-is-not-reliable-results-of-expert-review-of-archived-images-in-ukctocs
#9
Will Stott, Stuart Campbell, Angelo Franchini, Oleg Blyuss, Alexey Zaikin, Andy Ryan, Chris Jones, Aleksandra Gentry-Maharaj, Gwendolen Fletcher, Jatinderpal Kalsi, Steve Skates, Max Parmar, Nazar Amso, Ian Jacobs, Usha Menon
OBJECTIVE: In UKCTOCS self-reported visualization rates(srVR) at annual TVS scan was a key quality control(QC) metric. Our objective was to independently assess srVR using expert review and develop software capable of monitoring it. METHODS: Images from 1,000 examinations randomly selected from 68,951 archived annual TVS exams undertaken between 2008-2011 where the ovaries were reported as 'seen and normal' were reviewed by a single expert. Software was developed to identify exact images used to measure ovaries by measuring caliper dimensions and matching them to that recorded by the sonographer...
August 10, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28795589/a-novel-series-of-n-pyridin-2-yl-4-thiazol-5-yl-pyrimidin-2-amines-as-highly-potent-cdk4-6-inhibitors
#10
Solomon Tadesse, Ge Zhu, Laychiluh B Mekonnen, Jimma L Lenjisa, Mingfeng Yu, Michael P Brown, Shudong Wang
AIM: Inhibitors of CDK4/6 have emerged as a powerful class of therapeutics for treatment of several malignancies. We herein describe the identification of a new series of molecules that demonstrated excellent selectivity for CDK4/6 over CDKs1, 7 and 9. RESULTS: Medicinal chemistry optimization led to the discovery of 58 and 69 that inhibited CDK4 and CDK4/6, respectively, with high potency and selectivity, and 58 and 69 exhibited potent antiproliferative activities in a panel of human cancer cell lines including leukemia, and cancers of the breast, colon, ovary, pancreas and prostate...
August 10, 2017: Future Medicinal Chemistry
https://www.readbyqxmd.com/read/28793867/the-effect-of-nullomer-derived-peptides-9r-9s1r-and-124r-on-the-nci-60-panel-and-normal-cell-lines
#11
Abdelkrim Alileche, Greg Hampikian
BACKGROUND: Nullomer peptides are the smallest sequences absent from databases of natural proteins. We first began compiling a list of absent 5-amino acid strings in 2006 (1). We report here the effects of Nullomer-derived peptides 9R, 9S1R and 124R on the NCI-60 panel, derived from human cancers of 9 organs (kidney, ovary, skin melanoma, lung, brain, lung, colon, prostate and the hematopoietic system), and four normal cell lines (endothelial HUVEC, skin fibroblasts BJ, colon epithelial FHC and normal prostate RWPE-1)...
August 9, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28791769/fluorescent-polymer-nanoparticles-for-cell-barcoding-in-vitro-and-in-vivo
#12
Bohdan Andreiuk, Andreas Reisch, Marion Lindecker, Gautier Follain, Nadine Peyriéras, Jacky G Goetz, Andrey S Klymchenko
Fluorescent polymer nanoparticles for long-term labeling and tracking of living cells with any desired color code are developed. They are built from biodegradable poly(lactic-co-glycolic acid) polymer loaded with cyanine dyes (DiO, DiI, and DiD) with the help of bulky fluorinated counterions, which minimize aggregation-caused quenching. At the single particle level, these particles are ≈20-fold brighter than quantum dots of similar color. Due to their identical 40 nm size and surface properties, these nanoparticles are endocytosed equally well by living cells...
August 9, 2017: Small
https://www.readbyqxmd.com/read/28790267/-a-case-of-recurrent-colorectal-cancer-with-bilateral-ovarian-metastases-that-were-reduced-with-regorafenib-therapy
#13
Shiro Nakae, Yuya Nogi, Jun Arima, Daiki Okamoto, Naoki Urakawa, Masataka Fujikawa, Hidetoshi Gon, Atsushi Takebe, Makoto Shinzeki, Kenichi Tanaka, Hideto Senzaki
A 63-year-old woman had recurrences of metastatic rectal cancer in the lung, peritoneum, and ovary. Regorafenib was administered at 160mg/day as third-line chemotherapy. The patient developed Grade(Gr)3 hand-foot syndrome(HFS) and Gr 2 rash, but the abdominal distension and pain were relieved by the 1st course. Analgesics could be reduced and regorafenib was administrated at reduced dosage. The patient received keishi-bukuryo-gan(EK-25)and sai-rei-tou(TJ-114) for HFS. At the beginning of therapy, ovarian metastases were not reduced and showed poor contrast enhancement on CT...
July 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28775133/italian-pool-of-asbestos-workers-cohorts-mortality-trends-of-asbestos-related-neoplasms-after-long-time-since-first-exposure
#14
Daniela Ferrante, Elisabetta Chellini, Enzo Merler, Venere Pavone, Stefano Silvestri, Lucia Miligi, Giuseppe Gorini, Vittoria Bressan, Paolo Girardi, Laura Ancona, Elisa Romeo, Ferdinando Luberto, Orietta Sala, Corrado Scarnato, Simona Menegozzo, Enrico Oddone, Sara Tunesi, Patrizia Perticaroli, Aldo Pettinari, Francesco Cuccaro, Stefano Mattioli, Antonio Baldassarre, Francesco Barone-Adesi, Tiziana Cena, Patrizia Legittimo, Alessandro Marinaccio, Dario Mirabelli, Marina Musti, Roberta Pirastu, Alessandra Ranucci, Corrado Magnani
OBJECTIVE: Asbestos is a known human carcinogen, with evidence for malignant mesothelioma (MM), cancers of lung, ovary, larynx and possibly other organs. MM rates are predicted to increase with a power of time since first exposure (TSFE), but the possible long-term attenuation of the trend is debated. The asbestos ban enforced in Italy in 1992 gives an opportunity to measure long-term cancer risk in formerly exposed workers. METHODS: Pool of 43 previously studied Italian asbestos cohorts (asbestos cement, rolling stock, shipbuilding), with mortality follow-up updated to 2010...
August 3, 2017: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28774621/zebrafish-embryo-toxicity-of-15-chlorinated-brominated-and-iodinated-disinfection-by-products
#15
David Hanigan, Lisa Truong, Michael Simonich, Robert Tanguay, Paul Westerhoff
Disinfection to protect human health occurs at drinking water and wastewater facilities through application of non-selective oxidants including chlorine. Oxidants also transform organic material and form disinfection by-products (DBPs), many of which are halogenated and cyto- and genotoxic. Only a handful of assays have been used to compare DBP toxicity, and researchers are unsure which DBP(s) drive the increased cancer risk associated with drinking chlorinated water. The most extensive data set employs an in vitro model cell, Chinese hamster ovary cells...
August 2017: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/28772202/the-role-of-surgical-excision-for-the-krukenberg-tumour-a-case-report
#16
David Lam, Eugene Ong
INTRODUCTION: Krukenberg tumour (KT), which represents carcinoma in the ovary, is an uncommon manifestation of metastatic colorectal cancer. It is associated with poor prognosis and a high incidence of peritoneal metastatic disease. PRESENTATION OF CASE: The authors present a case of a 51-year-old female who had a symptomatic, metachronous right ovarian KT diagnosed 12 months after her initial resection. Surgery was performed to excise the 23cm tumour as well as the contralateral ovary and isolated peritoneal disease, with an R0 resection achieved...
July 25, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28766468/expectations-and-limitations-of-ovarian-tissue-transplantation
#17
N J Donfack, K A Alves, V R Araújo, A Cordova, J R Figueiredo, J Smitz, A P R Rodrigues
Constant progress in the diagnosis and treatment of cancer disease has increased the number and prognosis of cancer survivors. However, the toxic effects of chemotherapy and radiotherapy on ovarian function have resulted in premature ovarian failure. Patients are, therefore, still expecting methods to be developed to preserve their fertility successfully. Several potential options are available to preserve fertility in patients who face premature ovarian failure, including immature or mature oocyte and embryo cryopreservation...
August 2, 2017: Zygote: the Biology of Gametes and Early Embryos
https://www.readbyqxmd.com/read/28763739/risk-of-malignancy-on-suspicion-of-polyps-in-menopausal-women
#18
Sandra Bel, Camille Billard, Julien Godet, Victor Viviani, Cherif Akladios, Aline Host, Emilie Faller, Thomas Boisrame, Michel Hummel, Jean-Jacques Baldauf, Lise Lecointre, Olivier Garbin
Improved performances in gynaecological ultrasonography have enabled an increasing number of often asymptomatic endometrial polyps to be detected. Most of these polyps are removed surgically, as a precautionary measure, so as not to miss a case of endometrial cancer. Nonetheless, this management strategy is based solely on the sonographer's judgement and a number of these operations, which are probably of no benefit, could be avoided. In order to do so, risk factors for malignancy need to be identified. OBJECTIVE: Estimate the prevalence of lesions in menopausal patients with a pre-operative diagnosis of endometrial polyp...
July 15, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28763365/ultrasound-guided-laparoscopic-ovarian-wedge-resection-in-recurrent-serous-borderline-ovarian-tumours
#19
Benjamin P Jones, Srdjan Saso, Jessica Farren, Mona El-Bahrawy, Sadaf Ghaem-Maghami, J Richard Smith, Joseph Yazbek
OBJECTIVE: The aim of this study was to demonstrate the use of intraoperative ultrasound-guided ovarian wedge resection in the treatment of recurrent serous borderline ovarian tumors (sBOTs) that are too small to be visualized laparoscopically. METHODS: This was a prospective analysis of all women with recurrent sBOTs that were not visible laparoscopically, who underwent intraoperative ultrasound-guided ovarian wedge resection between January 2015 and December 2016 at the West London Gynaecological Cancer Centre, Imperial College NHS Trust, London, United Kingdom...
August 1, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28762556/nadph-oxidase-5-nox5-induced-reactive-oxygen-signaling-modulates-normoxic-hif-1%C3%AE-and-p27-kip1-expression-in-malignant-melanoma-and-other-human-tumors
#20
Smitha Antony, Guojian Jiang, Yongzhong Wu, Jennifer L Meitzler, Hala R Makhlouf, Diana C Haines, Donna Butcher, Dave S Hoon, Jiuping Ji, Yiping Zhang, Agnes Juhasz, Jiamo Lu, Han Liu, Iris Dahan, Mariam Konate, Krishnendu K Roy, James H Doroshow
NADPH oxidase 5 (NOX5) generated reactive oxygen species (ROS) have been implicated in signaling cascades that regulate cancer cell proliferation. To evaluate and validate NOX5 expression in human tumors, we screened a broad range of tissue microarrays (TMAs), and report substantial overexpression of NOX5 in malignant melanoma and cancers of the prostate, breast, and ovary. In human UACC-257 melanoma cells that possesses high levels of functional endogenous NOX5, overexpression of NOX5 resulted in enhanced cell growth, increased numbers of BrdU positive cells, and increased γ-H2AX levels...
August 1, 2017: Molecular Carcinogenesis
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