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https://www.readbyqxmd.com/read/29785550/does-tumor-grade-influence-the-rate-of-lymph-node-metastasis-in-apparent-early-stage-ovarian-cancer
#1
Dimitrios Nasioudis, Spyridon A Mastroyannis, Emily M Ko, Nawar A Latif
PURPOSE: To evaluate the prevalence of regional lymph node (LN) metastasis in patients with non-clear cell epithelial ovarian cancer apparently confined to the ovary, stratified by tumor grade. METHODS: The National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) database was accessed (1988-2014). We identified patients with epithelial ovarian carcinoma of serous, endometrioid and mucinous histology apparently confined to the ovary who underwent extensive lymphadenectomy (defined as at least 20 lymph nodes removed)...
May 21, 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29783074/fsh-receptor-binding-inhibitor-restrains-follicular-development-and-possibly-attenuates-carcinogenesis-of-ovarian-cancer-through-down-regulating-expression-levels-of-fshr-and-er%C3%AE-in-normal-ovarian-tissues
#2
Gong Zhuandi, Che Tuanjie, Lai Luju, Ayimuguli Abdiryim, Deng Yingying, Liang Haoqin, Wei Suocheng, Ding Li
OBJECTIVES: The current study aimed to investigate FSH receptor binding inhibitor (FRBI) effects in the expressions of FSH receptor (FSHR) and estrogen receptor-beta (ERβ) in the mice ovaries at the gene and protein levels, also to find the potential efficacy of FRBI on suppressing ovarian cancer through down-regulating over-expression of FSHR and ERβ in the normal ovarian tissues. METHODS: 180 female mice were randomized into six groups (n = 30). Mice of FRBI-1, FRBI-2 and FRBI-3, FRBI-4 were intramuscularly injected with FRBI of 10, 20, 30 and 40 mg/kg, respectively, for five consecutive days...
May 18, 2018: Gene
https://www.readbyqxmd.com/read/29781548/multi-omics-in-high-grade-serous-ovarian-cancer-biomarkers-from-genome-to-the-immunome
#3
Cole Clifford, Natasha Vitkin, Sarah Nersesian, Gillian Reid-Schachter, Julie-Ann Francis, Madhuri Koti
Epithelial ovarian cancer (EOC) is a lethal gynaecological disease that imposes significant burden on health care and patient quality of life. High-grade serous carcinoma of the ovary (HGSC) is the most prevalent histological type of EOC. A vast majority of HGSC cases are diagnosed at late stages of the disease, limiting the opportunity for clinical intervention and resulting in a 10-year survival rate of <20%. Recent innovations in high-throughput molecular analysis of patient-derived specimens may address these clinical challenges by providing an enhanced understanding of the molecular aetiology of ovarian cancer, in addition to offering several opportunities for rational biomarker and targeted therapy discovery...
May 21, 2018: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29780295/successful-in-vitro-fertilization-and-embryo-transfer-after-transplantation-of-cryopreserved-ovarian-tissue-report-of-the-first-korean-case
#4
Jung Ryeol Lee, Dayong Lee, Soohyeon Park, Eun Chan Paik, Seul Ki Kim, Byung Chul Jee, Chang Suk Suh, Seok Hyun Kim
For patients at risk of premature ovarian failure with cancer treatment, it is an important option to re-implant the ovarian tissue (OT) after cryopreservation to preserve endocrine function and fertility. With this technique, about 30% of pregnancy success rate and about 90 live births have been reported to date. However, there has been no case report of successful in vitro fertilization (IVF) and embryo transfer (ET) with oocytes collected from transplanted cryopreserved OT in Korea. We report a 30-year old woman with rectal cancer who underwent IVF and ET after cryopreserved OT thawing and re-implantation...
May 21, 2018: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29778393/fertility-preservation-in-pediatric-female-cancer-patients
#5
Sara E Arian, Rebecca L Flyckt, Richard Herman, Hadi Erfani, Tommaso Falcone
OBJECTIVE: To describe and demonstrate ovarian tissue cryopreservation (OTC) as an emerging fertility preservation technique DESIGN: Video presentation. SETTING: University hospital. PATIENT(S): A 6 year-old female patient diagnosed with aplastic anemia with plan for bone marrow transplantation underwent laparoscopic unilateral oophorectomy in conjunction with surgical procedure for port placement by the pediatric surgeon, followed by cryopreservation of ovarian tissue...
May 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29770329/aeg-1-contributes-to-metastasis-in-hypoxia-related-ovarian-cancer-by-modulating-the-hif-1alpha-nf-kappab-vegf-pathway
#6
Xiaoyu Yu, Yan Wang, Huilei Qiu, Hongtao Song, Di Feng, Yang Jiang, Shuzhe Deng, Hongxue Meng, Jingshu Geng
Objective: Ovarian carcinoma represents one of the deadliest malignancies among female cancer patients. Astrocyte-elevated gene-1 (AEG-1) participates in the ontogenesis of multiple human malignant diseases. Here we evaluated AEG-1, hypoxia-inducible factor- (HIF-) 1 α , nuclear factor kappa-light-chain-enhancer of activated B cells (NF- κ B), and vascular endothelial growth factor (VEGF) amounts in hypoxia induced ovarian carcinoma cells. This study aimed to explore the mechanism by which AEG-1 regulates metastasis in hypoxia induced ovarian carcinoma...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29766242/inactivation-of-deubiquitinase-cyld-enhances-therapeutic-antibody-production-in-chinese-hamster-ovary-cells
#7
Yafang Lu, Qin Zhou, Qianqian Han, Pengfei Wu, Lanlan Zhang, Lin Zhu, David T Weaver, Changzhi Xu, Buchang Zhang
Chinese hamster ovary (CHO) cells are promising host engineering cells for industry manufacturing of therapeutic antibodies. However, cell death due to apoptosis remains a huge challenge to augment antibody production, and developing CHO cells with enhanced anti-apoptosis and proliferation ability is fundamental for cell line development and high-yielding bioprocesses. Deubiquitinase cylindromatosis (CYLD) has been proved to be a tumor suppressor by negatively regulating NF-κB and Wnt/β-catenin signaling pathways...
May 15, 2018: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29764959/a-targeted-rnai-screen-reveals-drosophila-female-sterile-genes-that-control-the-size-of-germline-stem-cell-niche-during-development
#8
Yueh Cho, Chun-Ming Lai, Kun-Yang Lin, Hwei-Jan Hsu
Adult stem cells maintain tissue homeostasis. This unique capability largely depends on the stem cell niche, a specialized microenvironment, which preserves stem cell identity through physical contacts and secreted factors. In many cancers, latent tumor cell niches are thought to house stem cells and aid tumor initiation. However, in developing tissue and cancer it is unclear how the niche is established. The well-characterized germline stem cells (GSCs) and niches in the Drosophila melanogaster ovary provide an excellent model to address this fundamental issue...
May 15, 2018: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/29763969/hormone-replacement-therapy-for-women-previously-treated-for-endometrial-cancer
#9
REVIEW
Katharine A Edey, Stuart Rundle, Martha Hickey
BACKGROUND: Endometrial cancer is the sixth most common cancer in women worldwide and most commonly occurs after the menopause (75%) (globocan.iarc.fr). About 319,000 new cases were diagnosed worldwide in 2012. Endometrial cancer is commonly considered as a potentially 'curable cancer,' as approximately 75% of cases are diagnosed before disease has spread outside the uterus (FIGO (International Federation of Gynecology and Obstetrics) stage I). The overall five-year survival for all stages is about 86%, and, if the cancer is confined to the uterus, the five-year survival rate may increase to 97%...
May 15, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29761000/quantitative-multispectral-ex-vivo-optical-evaluation-of-human-ovarian-tissue-using-spatial-frequency-domain-imaging
#10
Sreyankar Nandy, Ian S Hagemann, Matthew A Powell, Cary Siegel, Quing Zhu
About 85-90% of all ovarian cancers are carcinomas; these manifest clinically as mass-forming epithelial proliferations involving the ovary. In this study, a visible light spatial frequency domain imaging (SFDI) system was used for multispectral ex vivo imaging and quantitative evaluation of freshly excised benign and malignant human ovarian tissues. A total of 14 ovaries from 11 patients undergoing oophorectomy were investigated. Using a logistic regression model with seven significant spectral and spatial features extracted from SFDI images, a sensitivity of 94...
May 1, 2018: Biomedical Optics Express
https://www.readbyqxmd.com/read/29755773/early-experience-with-cytoreduction-and-hyperthermic-intraperitoneal-chemotherapy-at-a-newly-developed-center-for-peritoneal-malignancy
#11
Whitney L Guerrero, Gitonga Munene, Paxton V Dickson, Dina Darby, Andrew M Davidoff, Michael G Martin, Evan S Glazer, David Shibata, Jeremiah L Deneve
Background: Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) has improved outcomes for patients with peritoneal carcinomatosis (PC). We present our experience from a newly developed peritoneal surface malignancy program. Methods: An IRB approved retrospective review was performed for the first 50 patients treated with CRS/HIPEC with clinicopathologic data described. Results: Patients treated with CRS/HIPEC were Caucasian (64%), female (66%) with a median age of 53 years (range, 11-73 years)...
April 2018: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29752839/the-role-of-mtor-in-ovarian-cancer-polycystic-ovary-syndrome-and-ovarian-aging
#12
REVIEW
Jin Liu, Dai-Chao Wu, Li-Hua Qu, Hong-Qing Liao, Mei-Xiang Li
The mammalian target of rapamycin, mTOR, is a serine-threonine protein kinase downstream of the phosphatidylinositol 3-kinase (PI3K)-AKT axis. The pathway can regulate cell growth, proliferation, and survival by activating ribosomal kinases. Recent studies have implicated the mTOR signaling pathway in ovarian neoplasms, polycystic ovary syndrome (PCOS) and premature ovarian failure (POF). Preclinical investigations have demonstrated that the PI3K/AKT/mTOR pathway is frequently activated in the control of various ovarian functions...
May 12, 2018: Clinical Anatomy
https://www.readbyqxmd.com/read/29742861/clinical-etiology-of-hypermetabolic-pelvic-lesions-in-postoperative-positron-emission-tomography-computed-tomography-for-patients-with-rectal-and-sigmoid-cancer
#13
Yun Hee Kang, Eunji Han, Geon Park
PURPOSE: The purpose of this study was to present various clinical etiologies of hypermetabolic pelvic lesions on postoperative positron emission tomography/computed tomography (PET/CT) images for patients with rectal and sigmoid cancer. METHODS: Postoperative PET/CT images for patients with rectal and sigmoid cancer were retrospectively reviewed to identify hypermetabolic pelvic lesions. Positive findings were detected in 70 PET/CT images from 45 patients; 2 patients who were lost to follow-up were excluded...
April 2018: Annals of Coloproctology
https://www.readbyqxmd.com/read/29741763/endometrial-neoplasia-in-reproductive-aged-thai-women-with-polycystic-ovary-syndrome
#14
Suchada Indhavivadhana, Manee Rattanachaiyanont, Thanyarat Wongwananuruk, Kitirat Techatraisak, Nana Rayasawath, Chongdee Dangrat
OBJECTIVE: To determine the risk of endometrial neoplasia in relation to endometrial thickness and to evaluate factors influencing endometrial thickness in reproductive-aged Thai women with polycystic ovary syndrome (PCOS). METHODS: The present cross-sectional study was done at the Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand, between October 1, 2010, and January 31, 2013. We recruited women (aged ≥18 years) with PCOS diagnosed according to the revised 2003 Rotterdam criteria...
May 9, 2018: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/29737528/preterm-delivery-is-associated-with-an-increased-risk-of-epithelial-ovarian-cancer-among-parous-women
#15
Camilla Sköld, Tone Bjørge, Anders Ekbom, Anders Engeland, Mika Gissler, Tom Grotmol, Laura Madanat, Anne Gulbech Ording, Olof Stephansson, Britton Trabert, Steinar Tretli, Rebecca Troisi, Henrik Toft Sørensen, Ingrid Glimelius
Epithelial ovarian cancer is a fatal disease of largely unknown etiology. Higher parity is associated with reduced risk of ovarian cancer. However, among parous women, the impact of pregnancy-related factors on risk is not well understood. This population-based case-control study included all parous women with epithelial ovarian cancer in Denmark, Finland, Norway and Sweden during 1967-2013 (n=10,957) and up to 10 matched controls (n=107,864). We used conditional logistic regression to estimate odds ratios (ORs) with 95% confidence intervals (CIs) for pregnancy-related factors and ovarian cancer risk by histological subtype...
May 8, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29736365/parity-dependent-hemosiderin-and-lipofuscin-accumulation-in-the-reproductively-aged-mouse-ovary
#16
Ulises Urzua, Carlos Chacon, Renato Espinoza, Sebastián Martínez, Nicole Hernandez
The progressive decline of the ovarian follicle pool leads to reproductive ageing. The latter is accompanied by age-related disorders, including various types of cancer. In fact, the highest rates of ovarian cancer (OC) occur at postmenopause while OC risk is significantly modulated by parity records during previous fertile life. We approached the age-parity relationship in the C57BL/6 mouse model and herein describe the presence of nonheme iron (hemosiderin) and deposits of the "age pigment" lipofuscin in reproductively aged mouse ovaries by applying conventional histochemical methods and autofluorescence...
2018: Analytical Cellular Pathology (Amsterdam)
https://www.readbyqxmd.com/read/29735328/gynaecologic-cancer-surgery-and-preservation-of-fertility
#17
E Bentivegna, A Maulard, G Miailhe, S Gouy, P Morice
For gynecological cancers, even at an early stage, the standard treatment is "radical excision" involving hysterectomy (radical or not) with bilateral salpingo-oophorectomy. But for young patients with early stage disease, many recent studies have focused on preservation of subsequent fertility by keeping at least one ovary and the uterus. The main objective of this fertility-sparing surgery is to preserve fertility, if this can be accomplished without increasing the oncological risks. Whether the initial site of the cancer is the cervix, uterine fundus or ovary, the oncologic validation of fertility-sparing treatment requires several evaluation criteria: a rigorous clinical, radiological and surgical staging to verify that the pathology is truly at an early initial stage; expert pathologic interpretation of biopsy specimens to validate the histological criteria of "good prognosis"; provision of complete and understandable patient education verifying the true objectives for this fertility-sparing treatment (whose intent is to retain a potential for subsequent fertility without guaranteeing it) and provision of an explanation of the oncological constraints and implications of fertility-sparing surgery in the event of a possible pregnancy...
May 4, 2018: Journal of Visceral Surgery
https://www.readbyqxmd.com/read/29725467/association-between-ovarian-cancer-and-advanced-endometriosis
#18
Michail Matalliotakis, Charoula Matalliotaki, George N Goulielmos, Evridiki Patelarou, Maria Tzardi, Demetrios A Spandidos, Aydin Arici, Ioannis Matalliotakis
We retrospectively analyzed clinicopathological data in two different countries over the past years on the association between ovarian endometriosis and ovarian carcinoma. Medical and pathological reports were evaluated from 1,000 patients with endometriosis from two different geographical areas. The prevalence and women characteristics of cases were analyzed. Endometriosis-associated ovarian cancer was present in 20 (2%) cases, among the study subjects. The observed prevalence was 12 (60%) for endometrioid carcinoma, 4 (20%) for clear cell ovarian carcinoma, 2 (10%) for serous and 2 (10%) for mucinous adenocarcinoma...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29721183/delineating-the-hmgb1-and-hmgb2-interactome-in-prostate-and-ovary-epithelial-cells-and-its-relationship-with-cancer
#19
Aida Barreiro-Alonso, Mónica Lamas-Maceiras, Rosa García-Díaz, Esther Rodríguez-Belmonte, Lu Yu, Mercedes Pardo, Jyoti S Choudhary, María Esperanza Cerdán
High Mobility Group B (HMGB) proteins are involved in cancer progression and in cellular responses to platinum compounds used in the chemotherapy of prostate and ovary cancer. Here we use affinity purification coupled to mass spectrometry (MS) and yeast two-hybrid (Y2H) screening to carry out an exhaustive study of HMGB1 and HMGB2 protein interactions in the context of prostate and ovary epithelia. We present a proteomic study of HMGB1 partners based on immunoprecipitation of HMGB1 from a non-cancerous prostate epithelial cell line...
April 10, 2018: Oncotarget
https://www.readbyqxmd.com/read/29720853/secondary-metastatic-lesions-to-colon-and-rectum
#20
REVIEW
Michail Galanopoulos, Filippos Gkeros, Christos Liatsos, Christos Pontas, Apostolis Papaefthymiou, Nikos Viazis, Gerassimos J Mantzaris, Nikolaos Tsoukalas
Metastatic lesions of the colon are a rare clinical entity that may present difficulties in management. The incidence of these metastases appears to be increasing, as a result of physicians' greater awareness during follow-up investigations of a primary neoplasm. Furthermore, the presence of a greater proportion of these abnormalities at autopsy should be a triggering factor for further investigation for doctors dealing with colorectal oncology. Their clinical presentation may vary from asymptomatic to signs similar to those of colorectal cancer...
May 2018: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
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