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https://www.readbyqxmd.com/read/29775324/inversion-of-qubit-energy-levels-in-qubit-oscillator-circuits-in-the-deep-strong-coupling-regime
#1
F Yoshihara, T Fuse, Z Ao, S Ashhab, K Kakuyanagi, S Saito, T Aoki, K Koshino, K Semba
We report on experimentally measured light shifts of superconducting flux qubits deep-strongly coupled to LC oscillators, where the coupling constants are comparable to the qubit and oscillator resonance frequencies. By using two-tone spectroscopy, the energies of the six lowest levels of each circuit are determined. We find huge Lamb shifts that exceed 90% of the bare qubit frequencies and inversions of the qubits' ground and excited states when there are a finite number of photons in the oscillator. Our experimental results agree with theoretical predictions based on the quantum Rabi model...
May 4, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29773416/the-association-between-egfr-in-the-normal-or-mildly-impaired-range-and-incident-cadiovascular-disease-age-and-sex-analysis
#2
Alon Eisen, Avital Porter, Moshe Hoshen, Ran D Balicer, Orna Reges, Yardena Rabi, Morton Leibowitz, Zaza Iakobishvili, David Hasdai
BACKGROUND: Worse renal function, even in the normal or mildly impaired range, is associated with incident cardiovascular disease (CVD). Whether this association exists in both sexes across all ages is not known. METHODS: A population based cohort of individuals >22 years with no prior CVD and with an eGFR 60-130 ml/min/1.73 m2 . eGFR was calculated using the CKD-EPI formula. Incident CVD was defined as either myocardial infarction, unstable angina pectoris, coronary revascularization, or cerebrovascular event...
May 14, 2018: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/29771638/the-first-report-evaluating-the-post-exposure-rabies-prophylaxis-in-children-exposed-to-animals-in-the-lublin-province-eastern-poland-in-2010-2016-a-retrospective-study
#3
Joanna Krzowska-Firych, Ewelina Mazurek, Barbara Hasiec, Krzysztof Tomasiewicz
INTRODUCTION: Rabies continues to be one of the most important viral diseases and remains a significant threat to public health across the globe. The World Health Organization (WHO) has determined that most rabies cases occur in children. Dog bites on humans are a major public-health problem. Poland has not achieved rabies free status yet. Post-exposure prophylaxis (PEP) in humans can effectively prevent death after exposure to a potentially infected animal. THE AIM: The main objective of this study was to estimate the frequency of PEP among children exposed to animals, who had attended consultations at the Department of Infectious Diseases for Children in the Jan Boży Hospital in Lublin...
May 17, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29768505/multi-site-evaluation-of-the-ln34-pan-lyssavirus-real-time-rt-pcr-assay-for-post-mortem-rabies-diagnostics
#4
Crystal M Gigante, Lisa Dettinger, James W Powell, Melanie Seiders, Rene Edgar Condori Condori, Richard Griesser, Kenneth Okogi, Maria Carlos, Kendra Pesko, Mike Breckenridge, Edson Michael M Simon, Maria Yna Joyce V Chu, April D Davis, Scott J Brunt, Lillian Orciari, Pamela Yager, William C Carson, Claire Hartloge, Jeremiah T Saliki, Susan Sanchez, Mojgan Deldari, Kristina Hsieh, Ashutosh Wadhwa, Kimberly Wilkins, Veronica Yung Peredo, Patricia Rabideau, Nina Gruhn, Rolain Cadet, Shrikrishna Isloor, Sujith S Nath, Tomy Joseph, Jinxin Gao, Ryan Wallace, Mary Reynolds, Victoria A Olson, Yu Li
Rabies is a fatal zoonotic disease that requires fast, accurate diagnosis to prevent disease in an exposed individual. The current gold standard for post-mortem diagnosis of human and animal rabies is the direct fluorescent antibody (DFA) test. While the DFA test has proven sensitive and reliable, it requires high quality antibody conjugates, a skilled technician, a fluorescence microscope and diagnostic specimen of sufficient quality. The LN34 pan-lyssavirus real-time RT-PCR assay represents a strong candidate for rabies post-mortem diagnostics due to its ability to detect RNA across the diverse Lyssavirus genus, its high sensitivity, its potential for use with deteriorated tissues, and its simple, easy to implement design...
2018: PloS One
https://www.readbyqxmd.com/read/29765054/resolution-of-superluminal-signalling-in-non-perturbative-cavity-quantum-electrodynamics
#5
Carlos Sánchez Muñoz, Franco Nori, Simone De Liberato
Recent technological developments have made it increasingly easy to access the non-perturbative regimes of cavity quantum electrodynamics known as ultrastrong or deep strong coupling, where the light-matter coupling becomes comparable to the bare modal frequencies. In this work, we address the adequacy of the broadly used single-mode cavity approximation to describe such regimes. We demonstrate that, in the non-perturbative light-matter coupling regimes, the single-mode models become unphysical, allowing for superluminal signalling...
May 15, 2018: Nature Communications
https://www.readbyqxmd.com/read/29765040/dynamics-of-a-qubit-while-simultaneously-monitoring-its-relaxation-and-dephasing
#6
Q Ficheux, S Jezouin, Z Leghtas, B Huard
Decoherence originates from the leakage of quantum information into external degrees of freedom. For a qubit, the two main decoherence channels are relaxation and dephasing. Here, we report an experiment on a superconducting qubit where we retrieve part of the lost information in both of these channels. We demonstrate that raw averaging the corresponding measurement records provides a full quantum tomography of the qubit state where all three components of the effective spin-1/2 are simultaneously measured...
May 15, 2018: Nature Communications
https://www.readbyqxmd.com/read/29764319/rabies-in-alaska-from-the-past-to-an-uncertain-future
#7
Karsten Hueffer, Molly Murphy
Rabies is a serious zoonotic disease with significant public health consequences in the circumpolar North. Recent studies have advanced our understanding of the disease ecology in Alaska. In this paper, we review historical records of rabies in Alaska ranging from the late nineteenth century to the present, analyse the public health impact in the state and review studies on disease ecology before assessing challenges and anticipated altered disease dynamics in the face of a rapidly changing North. Rabies is a disease that has been present in Alaska continuously for over 100 years...
December 2018: International Journal of Circumpolar Health
https://www.readbyqxmd.com/read/29762559/gas-spectroscopy-with-integrated-frequency-monitoring-through-self-mixing-in-a-terahertz-quantum-cascade-laser
#8
Rabi Chhantyal-Pun, Alexander Valavanis, James T Keeley, Pierluigi Rubino, Iman Kundu, Yingjun Han, Paul Dean, Lianhe Li, A Giles Davies, Edmund H Linfield
We demonstrate a gas spectroscopy technique, using self-mixing in a 3.4 terahertz quantum-cascade laser (QCL). All previous QCL spectroscopy techniques have required additional terahertz instrumentation (detectors, mixers, or spectrometers) for system pre-calibration or spectral analysis. By contrast, our system self-calibrates the laser frequency (i.e., with no external instrumentation) to a precision of 630 MHz (0.02%) by analyzing QCL voltage perturbations in response to optical feedback within a 0-800 mm round-trip delay line...
May 15, 2018: Optics Letters
https://www.readbyqxmd.com/read/29761038/a-new-large-bodied-thalattosuchian-crocodyliform-from-the-lower-jurassic-toarcian-of-hungary-with-further-evidence-of-the-mosaic-acquisition-of-marine-adaptations-in-metriorhynchoidea
#9
Attila Ősi, Mark T Young, András Galácz, Márton Rabi
Based on associated and three-dimensionally preserved cranial and postcranial remains, a new thalattosuchian crocodyliform, Magyarosuchus fitosi gen. et sp. nov. from the Lower Jurassic (Upper Toarcian) Kisgerecse Marl Formation, Gerecse Mountains, Hungary is described here. Phylogenetic analyses using three different datasets indicate that M. fitosi is the sister taxon of Pelagosaurus typus forming together the basal-most sub-clade of Metriorhynchoidea. With an estimated body length of 4.67-4.83 m M. fitosi is the largest known non-metriorhynchid metriorhynchoid...
2018: PeerJ
https://www.readbyqxmd.com/read/29756911/dirac-equation-in-1-1-dimensional-curved-spacetime-and-the-multiphoton-quantum-rabi-model
#10
J S Pedernales, M Beau, S M Pittman, I L Egusquiza, L Lamata, E Solano, A Del Campo
We introduce an exact mapping between the Dirac equation in (1+1)-dimensional curved spacetime (DCS) and a multiphoton quantum Rabi model (QRM). A background of a (1+1)-dimensional black hole requires a QRM with one- and two-photon terms that can be implemented in a trapped ion for the quantum simulation of Dirac particles in curved spacetime. We illustrate our proposal with a numerical analysis of the free fall of a Dirac particle into a (1+1)-dimensional black hole, and find that the Zitterbewegung effect, measurable via the oscillatory trajectory of the Dirac particle, persists in the presence of gravity...
April 20, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29756908/orbital-state-manipulation-of-a-diamond-nitrogen-vacancy-center-using-a-mechanical-resonator
#11
H Y Chen, E R MacQuarrie, G D Fuchs
We study the resonant optical transitions of a single nitrogen-vacancy (NV) center that is coherently dressed by a strong mechanical drive. Using a gigahertz-frequency diamond mechanical resonator that is strain coupled to a NV center's orbital states, we demonstrate coherent Raman sidebands out to the ninth order and orbital-phonon interactions that mix the two excited-state orbital branches. These interactions are spectroscopically revealed through a multiphonon Rabi splitting of the orbital branches which scales as a function of resonator driving amplitude and is successfully reproduced in a quantum model...
April 20, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29753157/treosulfan-fludarabine-and-low-dose-total-body-irradiation-for-children-and-young-adults-with-acute-myeloid-leukemia-or-myelodysplastic-syndrome-undergoing-allogeneic-hematopoietic-cell-transplantation-a-prospective-phase-ii-trial-of-the-pediatric-blood-and
#12
Eneida R Nemecek, Ralf A Hilger, Alexia Adams, Bronwen E Shaw, Deidre Kiefer, Jennifer Le-Rademacher, John E Levine, Gregory Yanik, Wing Leung, Julie-An Talano, Paul Haut, David Delgado, Neena Kapoor, Aleksandra Petrovic, Roberta Adams, Rabi Hanna, Hemalatha Rangarajan, Jignesh Dalal, Joseph Chewning, Michael R Verneris, Stacy Epstein, Lauri Burroughs, Evelio D Perez-Albuerne, Michael A Pulsipher, Colleen Delaney
This multicenter study evaluated a treosulfan-based regimen in children and young adults with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) undergoing allogeneic hematopoietic cell transplant (HCT). Forty patients with median age 11 years (1-19) underwent allogeneic HCT for AML in first (n=18), second (n=11), third or greater remission (n=3); or MDS (n=8) using bone marrow (n=25), peripheral blood stem cells (n=5) or cord blood (n=9). The regimen consisted of body surface area (BSA)-based treosulfan 10 g/m2 /day (BSA ≤ 0...
May 9, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29752813/the-long-exercise-test-in-periodic-paralysis-a-bayesian-analysis
#13
Daniel B Simmons, Julie Lanning, James C Cleland, Araya Puwanant, Paul T Twydell, Robert C Griggs, Rabi Tawil, Eric L Logigian
INTRODUCTION: The long exercise test (LET) is used to assess the diagnosis of periodic paralysis (PP), but LET methodology and normal "cut-off" values vary. METHODS: To determine optimal LET methodology and cut-offs, we reviewed LET data (abductor digiti minimi (ADM) motor response amplitude, area) from 55 PP patients (32 genetically definite) and 125 controls. Receiver operating characteristic (ROC) curves were constructed and area-under-the-curve (AUC) calculated to compare 1) peak-to-nadir versus baseline-to-nadir methodologies, and 2) amplitude versus area decrements...
May 12, 2018: Muscle & Nerve
https://www.readbyqxmd.com/read/29751768/the-preclinical-evaluation-of-immunocontraceptive-vaccines-based-on-canine-zona-pellucida-3-czp3-in-a-mouse-model
#14
Ying Wang, Yijie Li, Beibei Zhang, Fuchun Zhang
BACKGROUND: Stray dogs are the reservoirs and carriers of rabies and are definitive hosts of echinococcosis. To control the overpopulation of stray dogs, zona pellucida 3 (ZP3), a primary receptor for sperm, is a potential antigen for developing contraceptive vaccines. To enhance the immune responses and contraceptive effects of canine ZP3 (cZP3), dog gonadotropin-releasing hormone (GnRH) and a T cell epitope of chicken ovalbumin (OVA) were selected to construct two fusion proteins with cZP3, ovalbumin-GnRH-ZP3 (OGZ) and ovalbumin-ZP3 (OZ), and their contraceptive effects were evaluated in mice...
May 11, 2018: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/29751323/evaluation-of-dosimetric-properties-of-shielding-disk-used-in-intraoperative-electron-radiotherapy-a-monte-carlo-study
#15
Mostafa Robatjazi, Hamid Reza Baghani, Seied Rabi Mahdavic, Giuseppe Felici
A shielding disk is used for IOERT procedures to absorb radiation behind the target and protect underlying healthy tissues. Setup variation of shielding disk can affect the corresponding in-vivo dose distribution. In this study, the changes of dosimetric parameters due to the disk setup variations is evaluated using EGSnrc Monte Carlo (MC) code. The results can help treatment team to decide about the level of accuracy in the setup procedure and delivered dose to the target volume during IOERT.
May 1, 2018: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/29746999/characterization-of-rabies-pdna-nanoparticulate-vaccine-in-poloxamer-407-gel
#16
Amit Bansal, Xianfu Wu, Victoria Olson, Martin J D'Souza
Plasmid DNA (pDNA) vaccines have the potential for protection against a wide range of diseases including rabies but are rapid in degradation and poor in uptake by antigen-presenting cells. To overcome the limitations, we fabricated a pDNA nanoparticulate vaccine. The negatively charged pDNA was adsorbed onto the surface of cationic PLGA (poly (d, l-lactide-co-glycolide))-chitosan nanoparticles and were used as a delivery vehicle. To create a hydrogel for sustainable vaccine release, we dispersed the pDNA nanoparticles in poloxamer 407 gel which is liquid at 4 °C and turns into soft gels at 37 °C, providing ease of administration and preventing burst release of pDNA...
May 7, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29745870/isolation-antigenicity-and-immunogenicity-of-lleida-bat-lyssavirus
#17
Ashley C Banyard, David Selden, Guanghui Wu, Leigh Thorne, Daisy Jennings, Denise Marston, Stefan Finke, Conrad M Freuling, Thomas Müller, Juan E Echevarría, Anthony R Fooks
The lyssaviruses are an important group of viruses that cause a fatal encephalitis termed rabies. The prototypic lyssavirus, rabies virus, is predicted to cause more than 60 000 human fatalities annually. The burden of disease for the other lyssaviruses is undefined. The original reports for the recently described highly divergent Lleida bat lyssavirus were based on the detection of virus sequence alone. The successful isolation of live Lleida bat lyssavirus from the carcass of the original bat and in vitro characterization of this novel lyssavirus are described here...
May 10, 2018: Journal of General Virology
https://www.readbyqxmd.com/read/29741619/small-noncoding-rnas-in-fshd2-muscle-cells-reveal-both-dux4-and-smchd1-specific-signatures
#18
Jong-Won Lim, Chao-Jen Wong, Zizhen Yao, Rabi Tawil, Silvère M van der Maarel, Daniel G Miller, Stephen J Tapscott, Galina N Filippova
Facioscapulohumeral muscular dystrophy (FSHD) is caused by insufficient epigenetic repression of D4Z4 macrosatellite repeat where DUX4, an FSHD causing gene is embedded. There are two forms of FSHD, FSHD1 with contraction of D4Z4 repeat and FSHD2 with chromatin compaction defects mostly due to SMCHD1 mutation. Previous reports showed DUX4-induced gene expression changes as well as changes in microRNA expression in FSHD muscle cells. However, a genome wide analysis of small noncoding RNAs that might be regulated by DUX4 or by mutations in SMCHD1 has not been reported yet...
May 8, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29740679/analysis-of-rabies-diagnosis-in-dogs-and-cats-in-the-state-of-s%C3%A3-o-paulo-brazil
#19
Juliana Galera Castilho, Samira Maria Achkar, Rafael de Novaes Oliveira, Enio Mori, Pedro Carnieli, Carla Isabel Macedo
The genetic lineage of rabies virus (RABV) associated with dogs has not been found in the state of São Paulo since 1998, and all cases of rabies in domestic animals reported since then have involved the RABV lineage that circulates in bats. As there has been a change in the rabies transmission cycle in cats and dogs, we decided to analyze the tests used to diagnose rabies in these animals in the 15-year period from 2002 to 2016 in the state of São Paulo. During this period, 85,508 central nervous system (CNS) samples from dogs and cats were submitted to the Rabies Diagnosis Section at the Pasteur Institute of São Paulo for testing...
May 8, 2018: Archives of Virology
https://www.readbyqxmd.com/read/29740190/does-duration-of-caffeine-therapy-in-preterm-infants-born-%C3%A2-1250-g-at-birth-influence-neurodevelopmental-nd-outcomes-at-3-years-of-age
#20
A Lodha, Y Rabi, A Soraisham, J Dobry, Arijit Lodha, H Amin, E Al Awad, S Tang, A Sahai, V Bhandari
OBJECTIVE: To evaluate the effect of duration of caffeine use on long-term neurodevelopmental (ND) outcomes at 3 years corrected age (CA) in preterm infants with birthweights (BW) ≤ 1250 g. DESIGN/METHODS: All surviving infants with BW ≤ 1250 g admitted to the Foothills Medical Center neonatal intensive care unit (NICU) from January 2002 to December 2009 who received the first dose of caffeine in the first week of life and were followed up at three years CA were included in the study...
May 8, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
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