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https://www.readbyqxmd.com/read/28430855/cancer-immunotherapy-trial-registrations-increase-exponentially-but-chronic-immunosuppressive-glucocorticoid-therapy-may-compromise-outcomes
#1
C M Connell, S Raby, I Beh, T Flint, E Williams, D T Fearon, D I Jodrell, T Janowitz
No abstract text is available yet for this article.
April 14, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28428486/antioxidative-protection-of-squalene-adjuvant-and-rabies-vaccine-with-adjuvant
#2
Anna Ondrejková, Judit Süli, Jarmila Harvanová, Róbert Ondrejka, Marián Prokeš
The authors verified the possibility of antioxidative protection of squalene adjuvant emulsions by the antioxidants α-tocopherol and β-carotene. They determined the influence of β-carotene on the stability and antigenic effectiveness of adjuvant emulsion in combination with rabies vaccine.The composition of the adjuvant emulsions or vaccines was: 2.5% squalene; 6% detergents; 0.5% antioxidant; 91% water phase. The oxidative injury after UV-irradiation was followed by the detection of the peroxide value of the emulsions...
April 19, 2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28428485/pathological-lesions-in-the-central-nervous-system-and-peripheral-tissues-of-ddy-mice-with-street-rabies-virus-1088-strain
#3
Kazunori Kimitsuki, Kentaro Yamada, Nozomi Shiwa, Satoshi Inoue, Akira Nishizono, Chun-Ho Park
Most studies on rabies virus pathogenesis in animal models have employed fixed rabies viruses, and the results of those employing street rabies viruses have been inconsistent. Therefore, to clarify the pathogenesis of street rabies virus (1088 strain) in mice, 10(6) focus forming units were inoculated into the right hindlimb of ddY mice (6 weeks, female). At 3 days postinoculation (DPI), mild inflammation was observed in the hindlimb muscle. At 5 DPI, ganglion cells in the right lumbosacral spinal dorsal root ganglia showed chromatolysis...
April 20, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28427171/evaluation-of-intracavitary-administration-of-curcumin-for-the-treatment-of-sarcomatoid-mesothelioma
#4
Daniel L Pouliquen, Béatrice Nawrocki-Raby, Joëlle Nader, Stéphanie Blandin, Myriam Robard, Philippe Birembaut, Marc Grégoire
A rat model of sarcomatoid mesothelioma, mimicking some of the worst clinical conditions encountered, was established to evaluate the therapeutic potential of intracavitary curcumin administration.The M5-T1 cell line, selected from a collection established from F344 rats induced with asbestos, produces tumors within three weeks, with extended metastasis in normal tissues, after intraperitoneal inoculation in syngeneic rats. The optimal concentration/time conditions for killing M5-T1 cells with curcumin were first determined in vitro...
February 25, 2017: Oncotarget
https://www.readbyqxmd.com/read/28424945/date-palm-waste-biochars-alter-a-soil-respiration-microbial-biomass-carbon-and-heavy-metal-mobility-in-contaminated-mined-soil
#5
Mohammad I Al-Wabel, Adel Rabie A Usman, Abdullah S Al-Farraj, Yong Sik Ok, Adel Abduljabbar, Abdulelah I Al-Faraj, Abdelazeem S Sallam
A 30-day incubation experiment was conducted using a heavy metal-contaminated mined soil amended with date palm feedstock (FS) and its derivative biochars (BCs) at three pyrolysis temperatures of 300 (BC-300), 500 (BC-500), and 700 °C (BC-700) with different application rates (0.0, 5, 15, and 30 g kg(-1)) to investigate their short-term effects on soil respiration (CO2-C efflux), microbial biomass carbon (MBC), soil organic carbon (SOC), mobile fraction of heavy metals (Cd, Cu, Pb, Zn, Mn, and Fe), pH, and electrical conductivity (EC)...
April 19, 2017: Environmental Geochemistry and Health
https://www.readbyqxmd.com/read/28421186/cost-description-and-comparative-cost-efficiency-of-post-exposure-prophylaxis-and-canine-mass-vaccination-against-rabies-in-n-djamena-chad
#6
Rolande Mindekem, Monique Sarah Lechenne, Kemdongarti Service Naissengar, Assandi Oussiguéré, Bidjeh Kebkiba, Daugla Doumagoum Moto, Idriss Oumar Alfaroukh, Laurent Tinoanga Ouedraogo, Sahidou Salifou, Jakob Zinsstag
Rabies claims approximately 59,000 human lives annually and is a potential risk to 3.3 billion people in over 100 countries worldwide. Despite being fatal in almost 100% of cases, human rabies can be prevented by vaccinating dogs, the most common vector, and the timely administration of post-exposure prophylaxis (PEP) to exposed victims. For the control and prevention of human rabies in N'Djamena, the capital city of Chad, a free mass vaccination campaign for dogs was organized in 2012 and 2013. The campaigns were monitored by parallel studies on the incidence of canine rabies based on diagnostic testing of suspect animals and the incidence of human bite exposure recorded at selected health facilities...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/28420410/ethnopharmacologic-survey-of-medicinal-plants-used-to-treat-human-diseases-by-traditional-medical-practitioners-in-dega-damot-district-amhara-northwestern-ethiopia
#7
Muluken Wubetu, Tefera Abula, Getye Dejenu
BACKGROUND: One of the services that plants provide for human beings is their wider medicinal application. Although it is not fully assessed, the practice and wider use of traditional medicine is frequent in Ethiopia. Studies conducted previously are confined to the perceptions of modern and traditional health practitioners about traditional medicine. A total of 45 informants were selected purposefully from the study area. For collecting the data, semi-structured interviewees, observation and field walks were employed from August 10 to September 30/2014...
April 18, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28420073/future-prospects-for-the-development-of-cost-effective-adenovirus-vaccines
#8
REVIEW
Cyrielle Fougeroux, Peter J Holst
Vaccination is one of the most efficient tools for disease prevention, and a continuously growing field of research. However, despite progress, we still need more efficient and cost-effective vaccines that would improve access to those in need. In this review, we will describe the status of virus-vectored vaccine technology with a focus on adenoviral-based vaccines. Adenovirus (Ad) vaccines have proven to be efficient in military vaccinations against Ad4 and Ad7 and as highly efficient vectored vaccines against rabies...
March 23, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28418772/geographical-clusters-and-predictors-of-rabies-in-three-southeastern-states
#9
Sara Reilly, Wayne T Sanderson, W Jay Christian, Steven R Browning
The rabies virus causes progressive encephalomyelitis that is fatal in nearly 100% of untreated cases. In the United States, wildlife act as the primary reservoir for rabies; prevention, surveillance, and control costs remain high. The purpose of this study is to understand the current distribution of wildlife rabies in three southeastern states, with particular focus on raccoons as the primary eastern reservoir, as well as identify demographic and geographic factors which may affect the risk of human exposure...
April 18, 2017: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/28415972/community-based-survey-during-rabies-outbreaks-in-rangjung-town-trashigang-eastern-bhutan-2016
#10
Tenzin Tenzin, Jamyang Namgyal, Sangay Letho
BACKGROUND: Rabies is a highly fatal disease transmitted through the bite of a rabid animal. Human deaths can be prevented by prompt administering of rabies vaccine and rabies immunoglobulin following the exposure. An assessment of community knowledge, awareness and practices on rabies is important during outbreak to understand their preparedness and target educational messages and response activities by the rapid response team. METHODS: A rabies outbreak has occurred in Rangjung town, eastern Bhutan on 4 October 2016...
April 17, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28415231/gap-solitons-in-rabi-lattices
#11
Zhaopin Chen, Boris A Malomed
We introduce a two-component one-dimensional system, which is based on two nonlinear Schrödinger or Gross-Pitaevskii equations (GPEs) with spatially periodic modulation of linear coupling ("Rabi lattice") and self-repulsive nonlinearity. The system may be realized in a binary Bose-Einstein condensate, whose components are resonantly coupled by a standing optical wave, as well as in terms of the bimodal light propagation in periodically twisted waveguides. The system supports various types of gap solitons (GSs), which are constructed, and their stability is investigated, in the first two finite bandgaps of the underlying spectrum...
March 2017: Physical Review. E
https://www.readbyqxmd.com/read/28413559/intracranial-hemorrhage-from-giant-aneurysm-in-pregnancy-a-rare-association
#12
Manasi Mehrotra, Anant Mehrotra, Anup Nair, Arun Srivastava, Rabi Narayan Sahu, Mandakini Pradhan, Raj Kumar
We report a case of giant aneurysm causing subarachnoid hemorrhage in a pregnant female. A 25-year-old female presented with sudden onset of severe headache and vomiting with altered sensorium and right hemiplegia. On investigation, she had a giant supraclinoid segment internal carotid artery (ICA) aneurysm. She was planned for digital substraction angiography, but during the procedure she deteriorated neurologically and went into spontaneous labor. The baby was a male child with weight of 1.1 kg. She was taken up for surgery and aneurysm was clipped...
January 2017: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/28413555/dissecting-intracranial-aneurysm-in-pregnancy-a-rare-association
#13
Manasi Mehrotra, Anant Mehrotra, Anup Nair, Arun Srivastava, Rabi Narayan Sahu, Mandakini Pradhan, Raj Kumar
We report a case of dissecting aneurysm of the right posterior cerebral artery presenting with sudden onset headache and altered behavior during labor. A 26-year-old P1001 with uncomplicated antenatal period, except history of headache off and on since 32 weeks of pregnancy, developed sudden onset headache and altered behavior during 3(rd) stage of labor. She had vaginal delivery and a live born male baby was delivered with good Apgar score. The CT was suggestive of subarachnoid hemorrhage and DSA was suggestive of dissecting aneurysm of the right P2 segment with hypoplasia of right P1 segment and A1 segment of posterior and anterior cerebral artery, respectively...
January 2017: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/28413547/supratentorial-intermediate-grade-meningeal-melanocytoma-with-intratumoral-bleed-in-the-background-of-neurocutaneous-melanosis-report-of-an-unusual-case-and-review-of-literature
#14
Kuntal Das, Anup Nair, Sushila Jaiswal, Rabi Sahu, Arun Srivastava, Raj Kumar, Anant Mehrotra
Primary melanocytic tumours of the central nervous system (CNS) are rare. According to the WHO classification (2007), these tumours include diffuse leptomeningeal melanosis, melanomatosis, melanocytoma, and primary CNS melanoma. Meningeal melanocytoma, most commonly seen in the infratentorial compartment and cervical spinal cord, is a benign primary melanocytic neoplasm. Primary CNS melanoma, on the other hand, represents the malignant end of the spectrum. Intermediate grade melanocytoma is a rare histological subtype of primary meningeal tumours and is characterised by the clinicopathological features between the two extremes...
January 2017: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/28413529/an-evaluation-of-neuroendocrine-dysfunction-following-acute-aneurysmal-subarachnoid-hemorrhage-a-prospective-study
#15
Awadhesh Kumar Jaiswal, Subhash Yadav, Rabi Narayan Sahu, Anant Mehrotra, Sanjay Behari, Ashok Kumar Mahapatra
OBJECTIVE: The aim was to investigate the incidence and pattern of neuroendocrine changes in cases of acute aneurysmal subarachnoid hemorrhage (SAH). MATERIALS AND METHODS: Endocrine assessment was performed in 100 consecutive cases of acute aneurysmal SAH presenting within 7 days of ictus. The gonadotropic, somatotrophic, thyrotropic, and corticotrophic axes were evaluated for their possible dysfunction. RESULTS: A total of 100 cases (38 males, 62 females; age range - 17-76 years; mean age - 43...
January 2017: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/28412449/targeted-drug-delivery-system-to-neural-cells-utilizes-the-nicotinic-acetylcholine-receptor
#16
Rachel Huey, Barry O'Hagan, Paul McCarron, Susan Hawthorne
Drug delivery to the brain is still a major challenge in the field of therapeutics, especially for large and hydrophilic compounds. In order to achieve drug delivery of therapeutic concentration in the central nervous system, the problematic blood brain barrier (BBB) must be overcome. This work presents the formulation of a targeted nanoparticle-based drug delivery system using a specific neural cell targeting ligand, rabies virus derived peptide (RDP). Characterization studies revealed that RDP could be conjugated to drug-loaded PLGA nanoparticles of average diameter 257...
April 12, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28411355/rabies-acquired-through-kidney-transplantation-in-a-child-a-case-report
#17
Bassam Saeed, Mustafa Al-Mousawi
Rabies is usually transmitted to humans through bites of infected animals; however, it can rarely be transmitted through deceased donor organs or tissues when not suspected. Here, we report a case of rabies transmission in a child. The child was a 5-year-old girl who was admitted to the pediatric intensive care unit with encephalitis of unexplained cause 3.5 months after she received a kidney transplant from a deceased donor. The laboratory and imaging studies did not reveal any explanation for her rapidly declining clinical and neurologic condition, which ended with death 4 days after admission...
April 14, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28410688/education-and-training-of-medical-physics-in-iran-the-past-the-present-and-the-future
#18
Seyed Rabi Mahdavi, Behrouz Rasuli, Azam Niroomand-Rad
PURPOSE: The aim of this study was to investigate the current status of education and training programs in medical physics in Iran. METHODS: A questionnaire was designed and sent to 274 IAMP (Iranian Association of Medical Physicists) members focusing on these two topics: the educational situation (course syllabus, number of faculty members, number of PhD and MSc students and sub-fields offered in the department) and the professional situation (work experience, workplaces of medical physicists, postgraduate degrees that were granted and the amount of therapy and imaging equipment)...
April 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28406757/rabies-virus-exposure-of-brazilian-free-ranging-wildlife-from-municipalities-without-clinical-cases-in-humans-or-in-terrestrial-wildlife
#19
João Marcelo Azevedo de Paula Antunes, Larissa de Castro Demoner, Tatiana Morosini de Andrade Cruvinel, Ana Paula Kataoka, Luzia Fátima Alves Martorelli, Gustavo Puglia Machado, Jane Megid
Rabies is a zoonosis that causes thousands of animal and human deaths worldwide. Serological studies provide information concerning rabies virus circulation among animals and humans. We evaluated the circulation of the rabies virus in wildlife in nine municipalities of São Paulo State, Brazil. We took blood samples from 27 terrestrial animals of nine different mammalian species in locations without cases of rabies in human and wild terrestrial mammals. Sera were tested with the use of the rapid fluorescent focus inhibition test (RFFIT) for the detection of rabies virus-neutralizing antibodies (RVNA)...
April 13, 2017: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/28406752/comparison-of-the-immunogenicity-and-safety-of-the-purified-chick-embryo-cell-rabies-vaccine-manufactured-in-india-and-germany-a-randomised-single-blind-multicentre-phase-iv-clinical-study
#20
Gadey Sampath, Angelika Banzhoff, Alaka Deshpande, Claudius Malerczyk, Ashwani Kumar Arora, Hoshang Vakil, Scott Preiss
This phase IV, single blind study assessed the immunogenicity and safety of India-manufactured purified chick embryo cell rabies vaccine (PCECV), compared to a German-manufactured batch obtained by the same production process. A total of 340 participants enrolled at 2 study sites in India were randomised (1:1:1:1) in 4 groups to receive a 5-dose Essen regimen with either 1 of the 3 Indian batches (PCECV-I) or the German batch (PCECV-G), administered on Days (D) 0, 3, 7, 14 and 30. The lot-to-lot consistency of PCECV-I batches in terms of induced immune response at D14 was demonstrated...
April 13, 2017: Human Vaccines & Immunotherapeutics
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