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https://www.readbyqxmd.com/read/28550434/flagellin-fljb-as-an-adjuvant-to-the-recombinant-adenovirus-rabies-glycoprotein-vaccine-increases-immune-responses-against-rabies-in-mice
#1
Xingxing Xiao, Yun Zhang, Qiaolin Wei, Xiangping Yin
Rabies virus (RABV) causes an acute progressive viral encephalitis. Although currently licensed vaccines have an excellent safety and efficacy record, the development of a safer and more cost-effective vaccine is still being sought. An E1-deleted, replication-defective human adenovirus type 5 (HAd5) vector expressing RABV glycoprotein (HAd5-G) is thought to be a promising candidate vaccine for immune prophylaxis against rabies. Salmonella enterica serovar Typhimurium (S. Typhimurium) flagellin is a well-known immune adjuvant...
May 26, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28549493/the-adverse-effect-of-the-2-1-1-regimen-for-rabies-pep-in-preschool-children
#2
Shu Qing Liu, Xiao Yan Tao, Peng Cheng Yu, Chun Qiu Jin, Hong Jie Yu, Mei Shun Chen, Wu Yang Zhu
Post-exposure prophylaxis (PEP) has proved to be the most important measure for rabies prevention and control. There is little information regarding adverse reactions to the Essen and 2-1-1 regimens in preschool children (aged 0-6). We reexamined the outcomes of 1,109 preschool children who were vaccinated using SPEEDA under the Essen regimen between January 2011 and December 2012 and 1,267 preschool children under the 2-1-1 regimen between January 2013 and December 2014. We find that, in preschool children, the febrile reaction after the first 2-dose injection in the 2-1-1 regimen was significantly higher than that induced by the first 1-dose in the Essen procedure...
May 2017: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/28548007/childhood-abuse-and-neglect-attachment-states-of-mind-and-non-suicidal-self-injury
#3
Jodi Martin, K Lee Raby, Madelyn H Labella, Glenn I Roisman
This investigation examined preoccupied attachment states of mind as both a risk factor for non-suicidal self-injury (NSSI) and as a mechanism by which prospectively assessed childhood experiences of abuse and neglect predicted the frequency/severity of NSSI behavior up to age 26 years in 164 individuals (83 females) who were followed from birth in the Minnesota Longitudinal Study of Risk and Adaptation. Preoccupied (but not dismissing) states of mind regarding both childhood caregivers and adult romantic partners were correlated with more frequent/severe NSSI...
May 26, 2017: Attachment & Human Development
https://www.readbyqxmd.com/read/28542160/the-phylogeography-of-myotis-bat-associated-rabies-viruses-across-canada
#4
Susan Nadin-Davis, Noor Alnabelseya, M Kimberly Knowles
As rabies in carnivores is increasingly controlled throughout much of the Americas, bats are emerging as a significant source of rabies virus infection of humans and domestic animals. Knowledge of the bat species that maintain rabies is a crucial first step in reducing this public health problem. In North America, several bat species are known to be rabies virus reservoirs but the role of bats of the Myotis genus has been unclear due to the scarcity of laboratory confirmed cases and the challenges encountered in species identification of poorly preserved diagnostic submissions by morphological traits alone...
May 19, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28541146/assessment-of-the-immunogenicity-of-rabies-vaccine-preserved-by-vaporization-and-delivered-to-the-duodenal-mucosa-of-gray-foxes-urocyon-cinereoargenteus
#5
Todd G Smith, Xianfu Wu, James A Ellison, Ashutosh Wadhwa, Richard Franka, Gregory L Langham, Brianna L Skinner, Cathleen A Hanlon, Victor L Bronshtein
OBJECTIVE To assess the immunogenicity of thermostable live-attenuated rabies virus (RABV) preserved by vaporization (PBV) and delivered to the duodenal mucosa of a wildlife species targeted for an oral vaccination program. ANIMALS 8 gray foxes (Urocyon cinereoargenteus). PROCEDURES Endoscopy was used to place RABV PBV (n = 3 foxes), alginate-encapsulated RABV PBV (3 foxes), or nonpreserved RABV (2 foxes) vaccine into the duodenum of foxes. Blood samples were collected weekly to monitor the immune response...
June 2017: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/28537932/tension-pneumocephalus
#6
Alexa R Clement, Dhamodaran Palaniappan, Rabi K Panigrahi
No abstract text is available yet for this article.
May 23, 2017: Anesthesiology
https://www.readbyqxmd.com/read/28530102/manipulating-coherent-plasmon-exciton-interaction-in-single-silver-nanorod-on-monolayer-wse2
#7
Di Zheng, Shunping Zhang, Qian Deng, Meng Kang, Peter Nordlander, Hongxing Xu
Strong coupling between plasmons and excitons in nanocavities can result in the formation of hybrid plexcitonic states. Understanding the dispersion relation of plexcitons is important both for fundamental quantum science and for applications including optoelectronics and nonlinear optics devices. The conventional approach, based on statistics over different nanocavities suffers from large inhomogeneities from the samples, owing to the non-uniformity of nanocavities and the lack of control over the locations and orientations of the excitons...
May 22, 2017: Nano Letters
https://www.readbyqxmd.com/read/28530037/where-do-hiv-infected-adolescents-go-after-transfer-tracking-transition-transfer-of-hiv-infected-adolescents-using-linkage-of-cohort-data-to-a-health-information-system-platform
#8
Mary-Ann Davies, Priscilla Tsondai, Nicki Tiffin, Brian Eley, Helena Rabie, Jonathan Euvrard, Catherine Orrell, Hans Prozesky, Robin Wood, Dolphina Cogill, Andreas D Haas, Annette H Sohn, Andrew Boulle
INTRODUCTION: To evaluate long-term outcomes in HIV-infected adolescents, it is important to identify ways of tracking outcomes after transfer to a different health facility. The Department of Health (DoH) in the Western Cape Province (WCP) of South Africa uses a single unique identifier for all patients across the health service platform. We examined adolescent outcomes after transfer by linking data from four International epidemiology Databases to Evaluate AIDS Southern Africa (IeDEA-SA) cohorts in the WCP with DoH data...
May 16, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28523730/investigating-the-effect-of-carbon-source-on-rabies-virus-glycoprotein-production-in-pichia-pastoris-by-a-transcriptomic-approach
#9
Safa Ben Azoun, Héla Kallel
Several factors affect protein expression in Pichia pastoris, one among them is the carbon source. In this work, we studied the effect of this factor on the expression level of rabies virus glycoprotein (RABV-G) in two recombinant clones harboring seven copies of the gene of interest. The expression was driven either by the constitutive glyceraldehyde-3-phosphate dehydrogenase (GAP) promoter or the inducible alcohol oxidase1 (AOX1) promoter. Clones were compared in terms of cell physiology and carbon source metabolism...
May 18, 2017: MicrobiologyOpen
https://www.readbyqxmd.com/read/28521804/sero-prevalence-of-virus-neutralizing-antibodies-for-rabies-in-different-groups-of-dogs-following-vaccination
#10
R M S Pimburage, M Gunatilake, O Wimalaratne, A Balasuriya, K A D N Perera
BACKGROUND: Mass vaccination of dogs is considered fundamental for national rabies control programmes in Sri Lanka, as dog is the main reservoir and transmitter of the disease. METHODS: Dogs were followed to determine the sero-prevalence of antibodies to the rabies virus. Altogether 510 previously vaccinated and unvaccinated dogs with owners (domestic dogs) and dogs without owners (stray dogs) of the local guard dog breed in different age groups recruited from Kalutara District, Sri Lanka...
May 18, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28514853/targeting-the-central-nervous-system-cns-a-review-of-rabies-virus-targeting-strategies
#11
Mira Oswald, Simon Geissler, Achim Goepferich
The transport of drugs across the blood-brain barrier is challenging. The use of peptide sequences derived from viruses with a central nervous system (CNS) tropism is one elegant option. A prominent example is the rabies virus glycopeptide-29 (RVG-29), which is said to enable a targeted brain delivery. Although the entry mechanism of the rabies virus into the CNS is very well characterized, it is unknown whether RVG-29-functionalized drug delivery systems (DDSs) follow this pathway. RVG-29-functionalized DDSs present themselves with modifications of the RVG-29 peptide sequence and different physicochemical properties compared to the rabies virus...
May 17, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28507457/evaluating-the-performance-of-tg-43-protocol-in-esophageal-hdr-brachytherapy-viewpoint-to-trachea-inhomogeneity
#12
Seyed Mohsen Hosseini Daghigh, Hamid Reza Baghani, Seyed Mahmoud Reza Aghamiri, Seyed Rabi Mahdavi
AIM: The aim of this study is to evaluate the effect of air within trachea on dose calculations of esophageal HDR brachytherapy treatment planning. BACKGROUND: Dose calculations in esophageal HDR brachytherapy treatment planning systems are greatly based on TG-43 protocol which in all materials are considered to be water equivalent. MATERIALS AND METHODS: A cylindrical PMMA phantom with a tube in the center (neck equivalent phantom) accompanied by Flexitron HDR brachytherapy system was used in this study...
July 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/28506631/susceptibility-of-neuroblastoma-cells-to-rabies-virus-may-be-affected-by-passage-number
#13
Craig Pouliott, Michelle Dupuis, Kim Appler, Scott Brunt, Robert Rudd, April Davis
Maintaining a healthy, continuous immortalized cell line is essential for rabies laboratories that perform virus isolation assays and test for the presence of viral neutralizing antibodies. Individuals who routinely work with rabies virus, such as rabies laboratory employees, or those who may have a high potential for exposure to rabies virus, including veterinarians, should be tested for the presence of anti-rabies viral neutralizing antibodies (VNA) every 6-24 months, depending on potential exposure level...
May 12, 2017: Journal of Virological Methods
https://www.readbyqxmd.com/read/28503779/normal-amniotic-fluid-volume-across-gestation-comparison-of-statistical-approaches-in-1190-normal-amniotic-fluid-volumes
#14
Songthip T Ounpraseuth, Everett F Magann, Horace J Spencer, Nader Z Rabie, Adam T Sandlin
AIM: Ultrasound estimation and evaluation of amniotic fluid volume (AFV) is an important component of pregnancy surveillance and fetal well-being. The purpose of this study was to compare and contrast four statistical methods used to construct gestational age-specific reference intervals for the assessment of AFV. METHODS: A total of 1095 normal AFV derived from four studies that measured AFV using dye-dilution or direct measurement at the time of hysterotomy were used to construct reference intervals using polynomial regression, quantile regression, Royston and Wright mean and SD, and Cole's lambda mu sigma (LMS) methods...
May 15, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28503287/time-to-appreciate-avicenna-s-knowledge-of-rabies
#15
Nader Aghakhani, Mehdi Azami, Mohsen Ghomashlooyan, Alireza Nikoonejad
No abstract text is available yet for this article.
2017: Caspian Journal of Internal Medicine
https://www.readbyqxmd.com/read/28497528/frequency-swept-integrated-solid-effect
#16
Thach V Can, Ralph T Weber, Joseph J Walish, Timothy M Swager, Robert G Griffin
The efficiency of continuous wave dynamic nuclear polarization (DNP) experiments decreases at the high magnetic fields used in contemporary high-resolution NMR applications. To recover the expected signal enhancements from DNP, we explored time domain experiments such as NOVEL which matches the electron Rabi frequency to the nuclear Larmor frequency to mediate polarization transfer. However, satisfying this matching condition at high frequencies is technically demanding. As an alternative we report here frequency-swept integrated solid effect (FS-ISE) experiments that allow low power sweeps of the exciting microwave frequencies to constructively integrate the negative and positive polarizations of the solid effect, thereby producing a polarization efficiency comparable to (±10 % difference) NOVEL...
May 12, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28497505/resurgence-of-rabies-in-hungary-during-2013-2014-an-attempt-to-track-the-origin-of-identified-strains
#17
Á Hornyák, T Juhász, B Forró, S Kecskeméti, K Bányai
In 2013-2014, accumulation of rabies episodes raised concerns regarding ongoing elimination programme in Hungary. Nearly four dozen cases were identified over a 13-month period in the central region of the country far behind the immunization zones. Although the outbreak was successfully controlled, the origin of disease remained unknown. In this study, we sequenced the partial N and G genes from 47 Hungarian rabies virus (RV) strains isolated from the 2013-2014 outbreak. Sequencing and phylogenetic analysis of the N and G genes showed that the Hungarian RV isolates share high nucleotide similarity among each other (up to 100%)...
May 11, 2017: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/28497055/indigenous-wildlife-rabies-in-taiwan-ferret-badgers-a-long-term-terrestrial-reservoir
#18
Yu-Ching Lan, Tzai-Hung Wen, Chao-Chin Chang, Hsin-Fu Liu, Pei-Fen Lee, Chung-Yuan Huang, Bruno B Chomel, Yi-Ming A Chen
The emerging disease of rabies was confirmed in Taiwan ferret badgers (FBs) and reported to the World Organization for Animal Health (OIE) on July 17, 2013. The spread of wildlife rabies can be related to neighborhood countries in Asia. The phylogenetic analysis was conducted by maximum likelihood (ML) methods and the Bayesian coalescent approach based on the glycoprotein (G) and nucleoprotein (N) genes. The phylogeographic and spatial temporal dynamics of viral transmission were determined by using SPREAD, QGIS...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28492258/preparation-and-coherent-manipulation-of-pure-quantum-states-of-a-single-molecular-ion
#19
Chin-Wen Chou, Christoph Kurz, David B Hume, Philipp N Plessow, David R Leibrandt, Dietrich Leibfried
Laser cooling and trapping of atoms and atomic ions has led to advances including the observation of exotic phases of matter, the development of precision sensors and state-of-the-art atomic clocks. The same level of control in molecules could also lead to important developments such as controlled chemical reactions and sensitive probes of fundamental theories, but the vibrational and rotational degrees of freedom in molecules pose a challenge for controlling their quantum mechanical states. Here we use quantum-logic spectroscopy, which maps quantum information between two ion species, to prepare and non-destructively detect quantum mechanical states in molecular ions...
May 10, 2017: Nature
https://www.readbyqxmd.com/read/28491824/rabies-virus-infection-induces-microtubule-depolymerization-to-facilitate-viral-rna-synthesis-by-upregulating-hdac6
#20
Jie Zan, Song Liu, Dong-Nan Sun, Kai-Kun Mo, Yan Yan, Juan Liu, Bo-Li Hu, Jin-Yan Gu, Min Liao, Ji-Yong Zhou
Rabies virus (RABV) is the cause of rabies, and is associated with severe neurological symptoms, high mortality rate, and a serious threat to human health. Although cellular tubulin has recently been identified to be incorporated into RABV particles, the effects of RABV infection on the microtubule cytoskeleton remain poorly understood. In this study, we show that RABV infection induces microtubule depolymerization as observed by confocal microscopy, which is closely associated with the formation of the filamentous network of the RABV M protein...
2017: Frontiers in Cellular and Infection Microbiology
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