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https://www.readbyqxmd.com/read/28937772/terahertz-light-matter-interaction-beyond-unity-coupling-strength
#1
Andreas Bayer, Marcel Pozimski, Simon Schambeck, Dieter Schuh, Rupert Huber, Dominique Bougeard, Christoph Lange
Achieving control over light-matter interaction in custom-tailored nanostructures is at the core of modern quantum electrodynamics. In strongly and ultrastrongly coupled systems, the excitation is repeatedly exchanged between a resonator and an electronic transition at a rate known as the vacuum Rabi frequency ΩR. For ΩR approaching the resonance frequency ωc, novel quantum phenomena including squeezed states, Dicke superradiant phase transitions, the collapse of the Purcell effect, and a population of the ground state with virtual photon pairs are predicted...
September 22, 2017: Nano Letters
https://www.readbyqxmd.com/read/28931127/single-visit-rabies-pre-exposure-priming-induces-a-robust-anamnestic-antibody-response-after-simulated-post-exposure-vaccination-results-of-a-dose-finding-study
#2
Emile F F Jonker, Leonardus G Visser
Background: The current standard 3-dose intramuscular rabies PrEP schedule suffers from a number of disadvantages that severely limit accessibility and availability. The cost of is often prohibitive, it requires 3 visits to the clinic, and there are regular vaccine shortages. Methods: Volunteers ( N  = 30) were randomly assigned to 4 study arms: 1 standard dose intramuscular (IM) dose of PVRV (purified Vero cell rabies vaccine, Verorab), and 1/5th, 2/5th or 3/5th- fractional intradermal (ID) dose of PVRV in a single visit...
September 1, 2017: Journal of Travel Medicine
https://www.readbyqxmd.com/read/28931089/advanced-glycation-end-products-dietary-restriction-effects-on-bacterial-gut-microbiota-in-peritoneal-dialysis-patients-a-randomized-open-label-controlled-trial
#3
Rabi Yacoub, Melinda Nugent, Weijin Cai, Girish N Nadkarni, Lee D Chaves, Sham Abyad, Amanda M Honan, Shruthi A Thomas, Wei Zheng, Sujith A Valiyaparambil, Mark A Bryniarski, Yijun Sun, Michael Buck, Robert J Genco, Richard J Quigg, John C He, Jaime Uribarri
The modern Western diet is rich in advanced glycation end products (AGEs). We have previously shown an association between dietary AGEs and markers of inflammation and oxidative stress in a population of end stage renal disease (ESRD) patients undergoing peritoneal dialysis (PD). In the current pilot study we explored the effects of dietary AGEs on the gut bacterial microbiota composition in similar patients. AGEs play an important role in the development and progression of cardiovascular (CVD) disease. Plasma concentrations of different bacterial products have been shown to predict the risk of incident major adverse CVD events independently of traditional CVD risk factors, and experimental animal models indicates a possible role AGEs might have on the gut microbiota population...
2017: PloS One
https://www.readbyqxmd.com/read/28928726/phosphoprotein-gene-contributes-to-the-enhanced-apoptosis-induced-by-wild-type-rabies-virus-gd-sh-01-in-vitro
#4
Qin Tian, Yifei Wang, Qiong Zhang, Jun Luo, He Jiang, Boyue Zhang, Mingzhu Mei, Fan Wu, Yuting Wu, Jiaojiao Peng, Teng Long, Yongwen Luo, Xiaofeng Guo
Previous research demonstrated that the matrix protein (M) and glycoprotein (G) of attenuated rabies virus (RABV) strains are involved in the induction of host cell apoptosis. In this work, we show that wild-type (wt) RABV GD-SH-01 induces significantly greater apoptosis than the attenuated strain HEP-Flury. In order to identify the gene(s) accounting for this phenotype, five recombinant RABVs (rRABVs) were constructed by replacing each single gene of HEP-Flury with the corresponding gene of GD-SH-01. By using these rRABVs, we found that not only M and G, but also the phosphoprotein (P) plays an important role in inducing apoptosis...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28925795/application-of-replication-defective-west-nile-virus-vector-to-non-flavivirus-vaccine-targets
#5
Maryann Giel-Moloney, Michael Vaine, Linong Zhang, Mark Parrington, Beata Gajewska, Thorsten U Vogel, Svetlana O Pougatcheva, Xiaochu Duan, Timothy Farrell, Irina Ustyugova, Sanjay Phogat, Harry Kleanthous, Konstantin V Pugachev
The RepliVaxvaccine platform(RV) is based on flavivirus genomes that are rationally attenuated by deletion. The self-limiting infection provided by RV has been demonstrated to be safe, highly immunogenic and efficacious for several vaccine candidates against flaviviruses. Here respiratory syncytial virus (RSV) F, influenza virus HA, and Simian Immunodeficiency virus (SIV) Env proteins were expressed in place of either prM-E or C-prM-E gene deletions of the West Nile (WN) genome. The resulting RV-RSV, -influenza and -SIV vaccine prototypes replicated efficiently in complementing helper cells expressing the WN structural proteins in trans...
September 19, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28921430/production-of-recombinant-rabies-virus-glycoprotein-by-insect-cells-in-a-single-use-fixed-bed-bioreactor
#6
Daniella C Ventini-Monteiro, Renato M Astray, Carlos A Pereira
A single-use fixed-bed bioreactor (iCELLis nano) can be used for cultivating non adherent insect cells, which can be then recovered for scaling up or for harvesting a membrane-associated viral glycoprotein with high quality in terms of preserved protein structure and biological function. Here, we describe the procedures for establishing genetically modified Drosophila melanogaster Schneider 2 (S2) cell cultures in the iCELLis nano bioreactor and for quantifying by ELISA the recombinant rabies virus glycoprotein (rRVGP) synthesized...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28917641/changes-in-innervation-of-lumbar-motoneurons-and-organization-of-premotor-network-following-training-of-transected-adult-rats
#7
Loubna Khalki, Karina Sadlaoud, Julie Lerond, Jacques-Olivier Coq, Jean-Michel Brezun, Laurent Vinay, Patrice Coulon, Hélène Bras
Rats with complete spinal cord transection (SCT) can recover hindlimb locomotor function under strategies combining exercise training and 5-HT agonist treatment. This recovery is expected to result from structural and functional re-organization within the spinal cord below the lesion. To begin to understand the nature of this reorganization, we examined synaptic changes to identified gastrocnemius (GS) or tibialis anterior (TA) motoneurons (MNs) in SCT rats after a schedule of early exercise training and delayed 5-HT agonist treatment...
September 13, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/28916520/rubrocerebellar-feedback-loop-isolates-the-interposed-nucleus-as-an-independent-processor-of-corollary-discharge-information-in-mice
#8
Christy S Beitzel, Brenda D Houck, Samantha M Lewis, Abigail L Person
Understanding cerebellar contributions to motor coordination requires deeper insight into how the output structures of the cerebellum, the cerebellar nuclei, integrate their inputs and influence downstream motor pathways. The magnocellular red nucleus (RNm), a brainstem premotor structure, is a major target of the interposed nucleus (IN), and has also been described in previous studies to send feedback collaterals to the cerebellum. Because such a pathway is in a key position to provide motor efferent information to the cerebellum, satisfying predictions about the use of corollary discharge in cerebellar computations, we studied it in mice of both sexes...
September 15, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28915695/evaluation-of-intracavitary-administration-of-curcumin-for-the-treatment-of-sarcomatoid-mesothelioma
#9
Daniel L Pouliquen, Béatrice Nawrocki-Raby, Joëlle Nader, Stéphanie Blandin, Myriam Robard, Philippe Birembaut, Marc Grégoire
A rat model of sarcomatoid mesothelioma, mimicking some of the worst clinical conditions encountered, was established to evaluate the therapeutic potential of intracavitary curcumin administration. The M5-T1 cell line, selected from a collection established from F344 rats induced with asbestos, produces tumors within three weeks, with extended metastasis in normal tissues, after intraperitoneal inoculation in syngeneic rats. The optimal concentration/time conditions for killing M5-T1 cells with curcumin were first determined in vitro...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28913904/re-emergence-of-rabies-virus-maintained-by-canid-populations-in-paraguay
#10
A C F Amarilla, J C A Pompei, D B Araujo, F A Vázquez, R R Galeano, L M Delgado, G Bogado, M Colman, L Sanabria, K Iamamoto, R Garcia, D Assis, R Recalde, L F Martorelli, E Quiñones, A Cabello, M Martini, O Cosivi, E L Durigon, S R Favoretto
Paraguay has registered no human cases of rabies since 2004, and the last case in dogs, reported in 2009, was due to a variant maintained in the common vampire bat "Desmodus rotundus". In 2014, a dog was diagnosed as positive for rabies with aggression towards a boy and all required measures of control were successfully adopted. Epidemiological investigation revealed that the dog was not vaccinated and had been attacked by a crab-eating fox, "zorro" (Cerdocyon thous). The sample was diagnosed by the Official Veterinary Service of the Country and sent to the Center on Rabies Research from the University of São Paulo, Brazil, for antigenic and genetic characterization...
September 14, 2017: Zoonoses and Public Health
https://www.readbyqxmd.com/read/28913342/editorial-towards-elimination-of-dog-mediated-human-rabies
#11
EDITORIAL
Salome Dürr, Anna S Fahrion, Lea Knopf, Louise H Taylor
No abstract text is available yet for this article.
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/28913341/assessing-the-risk-of-a-canine-rabies-incursion-in-northern-australia
#12
Emily G Hudson, Victoria J Brookes, Michael P Ward
Rabies is a globally distributed virus that causes approximately 60,00 human deaths annually with >99% of cases caused by dog bites. Australia is currently canine rabies free. However, the recent eastward spread of rabies in the Indonesian archipelago has increased the probability of rabies entry into northern Australian communities. In addition, many northern Australian communities have large populations of free-roaming dogs, capable of maintaining rabies should an incursion occur. A risk assessment of rabies entry and transmission into these communities is needed to target control and surveillance measures...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/28911756/substantial-reductions-in-rabies-but-still-a-lot-to-be-done
#13
Maria Cristina Schneider, Lucia R Montebello Pereira
No abstract text is available yet for this article.
October 2017: Lancet Global Health
https://www.readbyqxmd.com/read/28911750/effect-of-counselling-on-health-care-seeking-behaviours-and-rabies-vaccination-adherence-after-dog-bites-in-haiti-2014-15-a-retrospective-follow-up-survey
#14
Melissa Dominique Etheart, Maxwell Kligerman, Pierre Dilius Augustin, Jesse D Blanton, Benjamin Monroe, Ludder Fleurinord, Max Millien, Kelly Crowdis, Natael Fenelon, Ryan MacLaren Wallace
BACKGROUND: Haiti has an integrated bite case management (IBCM) programme to counsel animal-bite victims on the risk of rabies and appropriate treatment, as well as the Haiti Animal Rabies Surveillance Program (HARSP) to examine the animals. We assessed the usefulness of the IBCM programme to promote best practices for rabies prophylaxis after exposure in a low-income rabies-endemic setting. METHODS: We did a retrospective follow-up survey of randomly selected bite victims who were counselled by Haiti's IBCM programme between May 15, 2014, and Sept 15, 2015...
October 2017: Lancet Global Health
https://www.readbyqxmd.com/read/28911652/microbiological-histological-and-biochemical-evidence-for-the-adverse-effects-of-food-azo-dyes-on-rats
#15
Khaled Elbanna, Osama Mohamed Sarhan, Manal Khider, Mohamed Elmogy, Hussein Hasan Abulreesh, Mohamed Rabie Shaaban
In this study, 120 lactic acid bacterial strains from different fermented dairy products as well as 10 bacterial intestinal isolates were evaluated for in vitro and in vivo degradation of various food azo dyes. Of these isolates, lactic acid bacteria (LAB) strains 13 and 100 and the intestinal isolates Ent2 and Eco5 exhibited 96-98% degradation of the tested food azo dyes within 5-6 hours. High performance liquid chromatography mass spectra of sunset yellow (E110) and carmoisine (E122) anaerobic degradation products by the intestinal isolates showed that they were structurally related to toxic aromatic amines...
July 2017: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28903875/risk-assessment-of-the-entry-of-canine-rabies-into-papua-new-guinea-via-sea-and-land-routes
#16
Victoria J Brookes, Andy Keponge-Yombo, David Thomson, Michael P Ward
Canine-rabies is endemic in parts of Indonesia and continues to spread eastwards through the Indonesian archipelago. Papua New Guinea (PNG) has a land border with Papua Province, Indonesia, as well as logging and fishing industry connections throughout Asia. PNG has a Human Development Index of 0.505; therefore, an incursion of canine-rabies could have devastating impacts on human (7.5 million) and animal populations. Given the known difficulties of rabies elimination in resource-scarce environments, an incursion of rabies into PNG would also likely compromise the campaign for global elimination of rabies...
September 15, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/28902833/rabies-screen-reveals-gpe-control-of-cocaine-triggered-plasticity
#17
Kevin T Beier, Christina K Kim, Paul Hoerbelt, Lin Wai Hung, Boris D Heifets, Katherine E DeLoach, Timothy J Mosca, Sophie Neuner, Karl Deisseroth, Liqun Luo, Robert C Malenka
Identification of neural circuit changes that contribute to behavioural plasticity has routinely been conducted on candidate circuits that were preselected on the basis of previous results. Here we present an unbiased method for identifying experience-triggered circuit-level changes in neuronal ensembles in mice. Using rabies virus monosynaptic tracing, we mapped cocaine-induced global changes in inputs onto neurons in the ventral tegmental area. Cocaine increased rabies-labelled inputs from the globus pallidus externus (GPe), a basal ganglia nucleus not previously known to participate in behavioural plasticity triggered by drugs of abuse...
September 13, 2017: Nature
https://www.readbyqxmd.com/read/28899628/a-novel-approach-to-a-rabies-vaccine-based-on-a-recombinant-single-cycle-flavivirus-vector
#18
Maryann Giel-Moloney, Alexander A Rumyantsev, Fred David, Monica Figueiredo, Brad Feilmeier, Teshome Mebatsion, Mark Parrington, Harry Kleanthous, Konstantin V Pugachev
The RepliVax® vaccine (RV) platform is based on flavivirus genomes that are rationally attenuated by deletion. These single-cycle RV vaccine candidates targeting flavivirus pathogens have been demonstrated to be safe, highly immunogenic, and efficacious in animal models, including non-human primates. Here we show utility of the technology for delivery of a non-flavivirus immunogen by engineering several West Nile-based RV vectors to express full-length rabies virus G protein. The rabies virus G protein gene was incorporated in place of different West Nile structural protein gene deletions...
September 9, 2017: Vaccine
https://www.readbyqxmd.com/read/28898730/immunogenicity-of-orfv-based-vectors-expressing-the-rabies-virus-glycoprotein-in-livestock-species
#19
Mathias Martins, Lok R Joshi, Fernando S Rodrigues, Deniz Anziliero, Rafael Frandoloso, Gerald F Kutish, Daniel L Rock, Rudi Weiblen, Eduardo F Flores, Diego G Diel
The parapoxvirus Orf virus (ORFV) encodes several immunomodulatory proteins (IMPs) that modulate host-innate and pro-inflammatory responses and has been proposed as a vaccine delivery vector for use in animal species. Here we describe the construction and characterization of two recombinant ORFV vectors expressing the rabies virus (RABV) glycoprotein (G). The RABV-G gene was inserted in the ORFV024 or ORFV121 gene loci, which encode for IMPs that are unique to parapoxviruses and inhibit activation of the NF-κB signaling pathway...
September 9, 2017: Virology
https://www.readbyqxmd.com/read/28898296/characterizing-the-interaction-between-physicians-pharmacists-and-pharmaceutical-representatives-in-a-middle-income-country-a-qualitative-study
#20
Rima Hajjar, Aya Bassatne, Mohamad Ali Cheaito, Rabie Naser El Dine, Sarah Traboulsy, Fadi Haddadin, Gladys Honein-AbouHaidar, Elie A Akl
BACKGROUND: Studies around the world have shown that interactions between pharmaceutical companies, pharmacists and physicians have a great influence on prescribing and drug dispensing practices. In middle-income countries, the nature and extent of these interactions have not been well researched. Our objectives were to qualitatively explore the nature of the interactions between pharmaceutical companies, physicians and pharmacists, their impact on drug prescription and dispensing practices in Lebanon...
2017: PloS One
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