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https://www.readbyqxmd.com/read/28807355/hydrogen-rich-pure-water-prevents-cigarette-smoke-induced-pulmonary-emphysema-in-smp30-knockout-mice
#1
Yohei Suzuki, Tadashi Sato, Masataka Sugimoto, Hario Baskoro, Keiko Karasutani, Aki Mitsui, Fariz Nurwidya, Naoko Arano, Yuzo Kodama, Shin-Ichi Hirano, Akihito Ishigami, Kuniaki Seyama, Kazuhisa Takahashi
Chronic obstructive pulmonary disease (COPD) is predominantly a cigarette smoke (CS)-triggered disease with features of chronic systemic inflammation. Oxidants derived from CS can induce DNA damage and stress-induced premature cellular senescence in the respiratory system, which play significant roles in COPD. Therefore, antioxidants should provide benefits for the treatment of COPD; however, their therapeutic potential remains limited owing to the complexity of this disease. Recently, molecular hydrogen (H2) has been reported as a preventive and therapeutic antioxidant...
August 11, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28800778/effects-of-intraoperative-peep-optimization-on-postoperative-pulmonary-complications-and-the-inflammatory-response-study-protocol-for-a-randomized-controlled-trial
#2
Zoltán Ruszkai, Erika Kiss, Ildikó László, Fanni Gyura, Erika Surány, Péter Töhötöm Bartha, Gergely Péter Bokrétás, Edit Rácz, István Buzogány, Zoltán Bajory, Erzsébet Hajdú, Zsolt Molnár
BACKGROUND: Patients undergoing general anesthesia and mechanical ventilation during major abdominal surgery commonly develop pulmonary atelectasis and/or hyperdistention of the lungs. Recent studies show benefits of lung-protective mechanical ventilation with the use of low tidal volumes, a moderate level of positive end-expiratory pressure (PEEP) and regular alveolar recruitment maneuvers during general anesthesia, even in patients with healthy lungs. The purpose of this clinical trial is to evaluate the effects of intraoperative lung-protective mechanical ventilation, using individualized PEEP values, on postoperative pulmonary complications and the inflammatory response...
August 11, 2017: Trials
https://www.readbyqxmd.com/read/28799879/the-pathophysiology-of-chronic-noncommunicating-hydrocephalus-lessons-from-continuous-intracranial-pressure-monitoring-and-ventricular-infusion-testing
#3
Per Kristian Eide
OBJECTIVE The pathophysiology of chronic noncommunicating hydrocephalus (ncHC) is poorly understood. This present study explored whether lessons about the pathophysiology of this clinical entity might be retrieved from results of overnight monitoring of pulsatile and static intracranial pressure (ICP) and ventricular infusion testing. METHODS The study cohort included adult patients (> 20 years of age) with chronic ncHC due to aqueductal stenosis in whom symptoms had lasted a minimum of 6 months. A reference cohort consisted of age- and sex-matched patients managed for communicating HC (cHC)...
August 11, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28792891/feasibility-and-validation-of-4-d-pulse-wave-imaging-in-phantoms-and-in-vivo
#4
Iason Z Apostolakis, Pierre Nauleau, Clement Papadacci, Matthew D McGarry, Elisa E Konofagou
Pulse wave Imaging (PWI) is a noninvasive technique for tracking the propagation of the pulse wave along the arterial wall. 3-D ultrasound imaging would aid in objectively estimating the PulseWave Velocity (PWV) vector. This study aims to introduce a novel PWV estimation method along the propagation direction, validate it in phantoms and test its feasibility in vivo. A silicone vessel phantom consisting of a stiff and a soft segment along the longitudinal axis and and a silicone vessel with a plaque were constructed...
August 3, 2017: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/28760509/pulmonary-mechanic-and-lung-histology-induced-by-crotalus-durissus-cascavella-snake-venom
#5
Joselito de Oliveira Neto, João Alison de Moraes Silveira, Daniel Silveira Serra, Daniel de Araújo Viana, Diva Maria Borges-Nojosa, Célia Maria Souza Sampaio, Helena Serra Azul Monteiro, Francisco Sales Ávila Cavalcante, Janaina Serra Azul Monteiro Evangelista
This study have analyzed the pulmonary function in an experimental model of acute lung injury, induced by the Crotalus durissus cascavella venom (C. d. cascavella) (3.0 μg/kg - i.p), in pulmonary mechanic and histology at 1 h, 3 h, 6 h, 12 h and 24 h after inoculation. The C. d. cascavella venom led to an increase in Newtonian Resistance (RN), Tissue Resistance (G) and Tissue Elastance (H) in all groups when compared to the control, particularly at 12 h and 24 h. The Histeresivity (η) increased 6 h, 12 h and 24 h after inoculation...
July 28, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28708959/assessment-of-the-potential-public-health-impact-of-herpes-zoster-vaccination-in-germany
#6
Desmond Curran, Desirée Van Oorschot, Lijoy Varghese, Lidia Oostvogels, Tomas Mrkvan, Romulo Colindres, Alfred von Krempelhuber, Anastassia Anastassopoulou
The aim of this study was to compare the public health impact of introducing two Herpes Zoster (HZ) vaccines, Zoster Vaccine Live (ZVL) versus a non-live adjuvanted subunit candidate vaccine (HZ/su), in the German population aged 50+ years split into three age cohorts, i.e. 50-59, 60-69 and 70+ years, respectively. A multi-cohort static Markov model was developed following age cohorts over their lifetime. Demographic data were obtained from the German federal statistical office. HZ incidence and the proportion of HZ individuals developing post-herpetic neuralgia (PHN) were derived from German specific sources...
July 14, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28682215/could-slackline-training-complement-the-fifa-11-programme-regarding-training-of-neuromuscular-control
#7
Tobias Jäger, Julian Kiefer, Inge Werner, Peter A Federolf
The current study compared changes in neuromuscular control between slackline training and the stabilization training elements of the FIFA 11+ programme. Twenty-five students in 2 groups performed a 12-unit training programme. The slackline training group (n = 13) exclusively trained with a slackline. The stabilization training group (n = 12) practised exercises as described in the second part of the FIFA 11+ programme. Improvements in balance were assessed using three tests for dynamic, quasi-static, and perturbed postural control: the star excursion balance test (SEBT), the closed-eye single-leg stance, and the MFT S3-Check...
September 2017: European Journal of Sport Science
https://www.readbyqxmd.com/read/28668659/morbidity-and-mortality-amongst-indian-hajj-pilgrims-a-3-year-experience-of-indian-hajj-medical-mission-in-mass-gathering-medicine
#8
Inam D Khan, Shahbaz A Khan, Bushra Asima, Syed B Hussaini, M Zakiuddin, F A Faisal
The Hajj, a mass-gathering of over 3.5-million pilgrims, faces challenges to global health-security, housing, food, water, transportation, communication, sanitation, crowd-control and security. The Indian Medical Mission extended health-security to approximately 140,000 pilgrims, through outreach medical teams, primary-care clinics, tent-clinics, secondary-care hospitals and evacuation capabilities. Data on medical attendance, bed-occupancy, investigations, referrals, medication usage and deaths was compared...
June 28, 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/28641817/-preventing-violence-in-schizophrenia-with-cognitive-remediation
#9
C Darmedru, C Demily, N Franck
OBJECTIVES: The association between schizophrenia and violence represents an important issue in psychiatry. Often highly publicized, violent acts raise the question of their detection, prevention, management and treatment. There is no single, direct and exclusive link between aggressiveness and the underlying psychiatric disorder. On the contrary, the processes underlying this violence are multiple and interlinked. In addition to static and dynamic risk factors, cognitive deficits play an important role in the genesis and maintenance of violent and aggressive behavior...
June 19, 2017: L'Encéphale
https://www.readbyqxmd.com/read/28636403/applying-precision-medicine-to-trial-design-using-physiology-extracorporeal-co2-removal-for-ards
#10
Ewan C Goligher, Marcelo B P Amato, Arthur S Slutsky
In clinical trials of therapies for ARDS, the average treatment effect in the study population may be attenuated because individual patient responses vary widely. This inflates sample size requirements and increases the cost and difficulty of conducting successful clinical trials. One solution is to enrich the study population with patients most likely to benefit based on predicted patient response to treatment (predictive enrichment). In this perspective, we apply the precision medicine paradigm to the emerging use of extracorporeal CO2 removal (ECCO2R) for ultra-protective ventilation in ARDS...
June 21, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28627088/astrogliosis-and-impaired-aquaporin-4-and-dystrophin-systems-in-idiopathic-normal-pressure-hydrocephalus
#11
Per Kristian Eide, Hans-Arne Hansson
AIMS: Idiopathic normal pressure hydrocephalus (iNPH) is one subtype of dementia that may improve following drainage of cerebrospinal fluid (CSF). This prospective observational study explored whether expression of the water channel aquaporin-4 (AQP4) and the anchoring molecule dystrophin 71 (Dp71) are altered at astrocytic perivascular endfeet and in adjacent neuropil of iNPH patient. Observations were related to measurements of pulsatile and static intracranial pressure (ICP). METHODS: The study included iNPH patients undergoing overnight monitoring of the pulsatile/static ICP, in whom a biopsy was taken from the frontal cerebral cortex during placement of the ICP sensor...
June 19, 2017: Neuropathology and Applied Neurobiology
https://www.readbyqxmd.com/read/28622373/a-versatile-and-low-cost-open-source-pipetting-robot-for-automation-of-toxicological-and-ecotoxicological-bioassays
#12
Sebastian Steffens, Leonie Nüßer, Thomas-Benjamin Seiler, Nadine Ruchter, Mark Schumann, Ricarda Döring, Catrina Cofalla, Avi Ostfeld, Elad Salomons, Holger Schüttrumpf, Henner Hollert, Markus Brinkmann
In the past decades, bioassays and whole-organism bioassay have become important tools not only in compliance testing of industrial chemicals and plant protection products, but also in the monitoring of environmental quality. With few exceptions, such test systems are discontinuous. They require exposure of the biological test material in small units, such as multiwell plates, during prolonged incubation periods, and do not allow online read-outs. It is mostly due to these shortcomings that applications in continuous monitoring of, e...
2017: PloS One
https://www.readbyqxmd.com/read/28611850/use-of-the-kalman-filter-for-aortic-pressure-waveform-noise-reduction
#13
Frank Lam, Hsiang-Wei Lu, Chung-Che Wu, Zekeriya Aliyazicioglu, James S Kang
Clinical applications that require extraction and interpretation of physiological signals or waveforms are susceptible to corruption by noise or artifacts. Real-time hemodynamic monitoring systems are important for clinicians to assess the hemodynamic stability of surgical or intensive care patients by interpreting hemodynamic parameters generated by an analysis of aortic blood pressure (ABP) waveform measurements. Since hemodynamic parameter estimation algorithms often detect events and features from measured ABP waveforms to generate hemodynamic parameters, noise and artifacts integrated into ABP waveforms can severely distort the interpretation of hemodynamic parameters by hemodynamic algorithms...
2017: Computational and Mathematical Methods in Medicine
https://www.readbyqxmd.com/read/28590893/acoustic-reflexes-in-normal-hearing-adults-typically-developing-children-and-children-with-suspected-auditory-processing-disorder-thresholds-real-ear-corrections-and-the-role-of-static-compliance-on-estimates
#14
Udit Saxena, Chris Allan, Prudence Allen
BACKGROUND: Previous studies have suggested elevated reflex thresholds in children with auditory processing disorders (APDs). However, some aspects of the child's ear such as ear canal volume and static compliance of the middle ear could possibly affect the measurements of reflex thresholds and thus impact its interpretation. Sound levels used to elicit reflexes in a child's ear may be higher than predicted by calibration in a standard 2-cc coupler, and lower static compliance could make visualization of very small changes in impedance at threshold difficult...
June 2017: Journal of the American Academy of Audiology
https://www.readbyqxmd.com/read/28582256/internet-based-exercise-therapy-using-algorithms-for-conservative-treatment-of-anterior-knee-pain-a-pragmatic-randomized-controlled-trial
#15
Tae Won Benjamin Kim, Nic Gay, Arpit Khemka, Jonathan Garino
BACKGROUND: Conservative treatment remains the first-line option, and there is significant medical evidence showing that home-based exercise therapy for the treatment of common causes of knee pain is effective. SimpleTherapy created an online platform that delivers Internet-based exercise therapy for common causes of knee pain. The system is driven by an algorithm that can process the user's feedback to provide an adaptive exercise regimen. This triple-armed, pragmatic randomized pilot was designed to evaluate if this telerehabilitation platform is safe and effective...
December 14, 2016: JMIR Rehabil Assist Technol
https://www.readbyqxmd.com/read/28578633/early-pulmonary-compliance-increase-during-cardiac-surgery-predicted-post-operative-lung-dysfunction
#16
Yann Sacuto, Thierry Sacuto
INTRODUCTION: Lung dysfunction following cardiac surgery is currently viewed as the consequence of atelectasis and lung injury. While the mechanism of atelectasis has been largely detailed, the pathogenesis of lung injury after cardiopulmonary bypass is still unclear. Based upon clinical and experimental studies, we hypothesized that lungs could be injured through a mechanical phenomenon. METHODS: We recorded pulmonary compliance at six key moments of a heart operation in 62 adult patients undergoing elective cardiac surgery...
June 1, 2017: Perfusion
https://www.readbyqxmd.com/read/28531978/quasi-static-and-ratcheting-properties-of-trabecular-bone-under-uniaxial-and-cyclic-compression
#17
Li-Lan Gao, Chao-Lei Wei, Chun-Qiu Zhang, Hong Gao, Nan Yang, Li-Min Dong
The quasi-static and ratcheting properties of trabecular bone were investigated by experiments and theoretical predictions. The creep tests with different stress levels were completed and it is found that both the creep strain and creep compliance increase rapidly at first and then increase slowly as the creep time goes by. With increase of compressive stress the creep strain increases and the creep compliance decreases. The uniaxial compressive tests show that the applied stress rate makes remarkable influence on the compressive behaviors of trabecular bone...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28502060/comparison-of-univent-tube-and-ez-blocker-in-one-lung-ventilation-airway-pressures-and-gas-exchange
#18
Tülay Hoşten, Can Aksu, Alparslan Kuş, Sevim Cesur, Neşe Türkyılmaz, Mine Solak
Univent tube (UT) and EZ-blocker were used for one-lung ventilation (OLV). UT is a single lumen tube with a small separate lumen containing a bronchial blocker. EZ-blocker differs with its unique y-shaped double-cuffed distal end. We aimed to compare these two airway devices effects on airway pressures, oxygenation, ventilation and haemodynamics during OLV. Patients undergoing elective thoracotomy for the first time were included in this prospective randomized study. Patients were divided into two groups as UT and EZ...
May 13, 2017: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/28468223/values-range-of-tympanometric-gradient-in-otitis-media-with-effusion
#19
Sertac Duzer, Oner Sakallioglu, Abdulvahap Akyigit, Cahit Polat, Hasan Cetiner, Nihat Susaman
INTRODUCTION: The aim of this study was to establish how reliable a given tympanogram is in predicting the presence or absence of a middle ear effusion, and to provide new views for the diagnostic information of tympanometry. The use of tympanometric gradient in addition to static admittance is the focus of this study. MATERIALS AND METHODS: The authors enrolled 146 female and 129 male patients. The participants were allocated into groups as follow: Group A1 consisted of 50 healthy children...
May 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28461164/chest-compliance-is-altered-by-static-compression-and-decompression-as-revealed-by-changes-in-anteroposterior-chest-height-during-cpr-using-the-resqpump-in-a-human-cadaver-model
#20
Nicolas Segal, Aaron E Robinson, Paul S Berger, Michael C Lick, Johanna C Moore, Bayert J Salverda, Mason B Hinke, Andrew A Ashton, Angela M McArthur, Keith G Lurie, Anja K Metzger
INTRODUCTION: Chest compliance plays a fundamental role in the generation of circulation during cardiopulmonary resuscitation (CPR). To study potential changes in chest compliance over time, anterior posterior (AP) chest height measurements were performed on newly deceased (never frozen) human cadavers during CPR before and after 5min of automated CPR. We tested the hypothesis that after 5min of CPR chest compliance would be significantly increased. METHODS: Static compression (30, 40, and 50kg) and decompression forces (-10, -15kg) were applied with a manual ACD-CPR device (ResQPUMP, ZOLL) before and after 5min of automated CPR...
July 2017: Resuscitation
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