Patricia Richey, Margaret Funk, Fernanda Sakamoto, Scott Plotkin, Ina Ly, Justin Jordan, Alona Muzikansky, Josh Roberts, William Farinelli, Yakir Levin, Lilit Garibyan, Jaishri O Blakeley, R Rox Anderson
BACKGROUND: People with Neurofibromatosis Type 1 (NF1) suffer disfigurement and pain when hundreds to thousands of cutaneous neurofibromas (cNFs) appear and grow throughout life. Surgical removal of cNFs under anesthesia is the only standard therapy, leaving surgical scars. OBJECTIVE: Effective, minimally-invasive, safe, rapid, tolerable treatment(s) of small cNFs that may prevent tumor progression. METHODS: Safety, tolerability, and efficacy of four different treatments were compared in 309, 2-4mm cNFs across 19 adults with Fitzpatrick skin types (FST) I-IV: radiofrequency (RF) needle coagulation, 755nm alexandrite laser with suction, 980nm diode laser, and intratumoral injection of 10mg/mL deoxycholate...
December 10, 2023: Journal of the American Academy of Dermatology