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https://www.readbyqxmd.com/read/29244886/the-modified-apically-repositioned-flap-technique-a-long-term-4-to-16-years-retrospective-study
#1
João Carnio, Paulo M Camargo, Perry R Klokkevold, Flavia Q Pirih
Attached gingiva is desirable for the maintenance of gingival health. Although many methods are used to increase the zone of attached gingiva, the modified apically repositioned flap (MARF) technique has the advantages of simplicity and predictability. The short-term follow-up of the MARF technique demonstrated an increase in keratinized tissue and attached gingiva. This study evaluated long-term results of the MARF technique as used to increase the apicocoronal dimensions of keratinized tissue and attached gingiva in 28 sites (25 patients; average follow-up of 9 years)...
December 15, 2017: International Journal of Periodontics & Restorative Dentistry
https://www.readbyqxmd.com/read/29244080/quantification-of-methadone-and-main-metabolites-in-nails
#2
Teresa Patrícia Magalhães, Sara Cravo, Diana Dias da Silva, Ricardo Jorge Dinis-Oliveira, Carlos Afonso, Maria de Lourdes Bastos, Helena Carmo
The quantification of drugs of abuse in keratinized matrices is becoming of special relevance for monitoring consumption and for post-mortem investigations. We aimed to implement an analytical method for the simultaneous detection of morphine (MORF), 6-monoacetylmorphine (6-MAM), methadone (MET), 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP) and 2-ethyl-5-methyl-3,3-diphenylpyrrolidine (EMDP) in nails. After decontamination, the nail samples (30 mg) were submitted to an alkaline digestion followed by a two-step liquid-liquid and SPE extraction using mixed-mode cation exchange cartridges...
December 13, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/29242581/il-33-is-induced-in-undifferentiated-non-dividing-esophageal-epithelial-cells-in-eosinophilic-esophagitis
#3
J Travers, M Rochman, J M Caldwell, J A Besse, C E Miracle, M E Rothenberg
The molecular and cellular etiology of eosinophilic esophagitis (EoE), an emerging tissue-specific allergic disease, involves dysregulated gene expression in esophageal epithelial cells. Herein, we assessed the esophageal expression of IL-33, an epithelium-derived alarmin cytokine, in patients with EoE. IL-33 protein was markedly overexpressed within the nuclei of a subpopulation of basal layer esophageal epithelial cells in patients with active EoE compared to control individuals. IL-33 exhibited dynamic expression as levels normalized upon EoE remission...
December 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29241101/marjolin-s-ulcer-in-a-20-years-old-split-thickness-skin-graft-on-the-knee-a-case-report
#4
Iselin Saltvig, Steen H Matzen
OBJECTIVE: Marjolin's Ulcer (MU) is a rare cutaneous neoplasm arising in cikatrical tissue. Due to its typical clinical presentation as a non-healing lesion in scar tissue, the diagnosis can be delayed and even overlooked. METHODS AND RESULTS: We present the case of an elderly woman who developed an ulcerated, exophytic lesion in a split thickness skin graft (STSG) on the lateral aspect of the left knee. Histology showed a radically excised highly differentiated squamous cell carcinoma (SCC) with keratine pearls and a component of basocellular carcinoma (BCC)...
December 5, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29240201/coronally-advanced-flap-with-site-specific-application-of-connective-tissue-graft-for-the-treatment-of-multiple-adjacent-gingival-recessions-a-3-year-follow-up-case-series
#5
Martina Stefanini, Giovanni Zucchelli, Matteo Marzadori, Massimo de Sanctis
The aim of this study was to evaluate the short- (1 year) and longer-term (3 years) effectiveness of a surgical procedure combining coronally advanced flap (CAF) with site-specific application of connective tissue graft (CTG) in the treatment of multiple gingival recessions (MGR). A total of 60 periodontally healthy subjects with esthetic complaints due to excessive tooth length presenting multiple (at least three) Miller Class I and II gingival recession defects (≥ 1 mm) affecting adjacent teeth in the maxilla and mandible were enrolled in the study...
January 2018: International Journal of Periodontics & Restorative Dentistry
https://www.readbyqxmd.com/read/29239471/age-related-changes-in-the-morphology-and-the-distribution-of-iga-and-igg-in-the-palatine-tonsils-of-yaks-bos-grunniens
#6
Juan Sun, Yuanfang Xu, Yan Cui, Penggang Liu, Sijiu Yu, Junfeng He, Qian Zhang, Yufeng Huang, Xue Yang
This study aimed to describe the age-related morphological changes and the distribution of IgA and IgG antibody-secreting cells (ASCs) in yaks. The palatine tonsils of twenty clinically healthy yaks, viz. newborn juvenile, adult and aged, were studied using histology, immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). The results showed that the palatine tonsils found in two tonsillar sinus were elongated kidney-shaped structures. Some external crypts and internal crypts were present. The palatine tonsils were partially enclosed by a connective tissue capsule and had trabeculae extending into the organ...
December 14, 2017: Histology and Histopathology
https://www.readbyqxmd.com/read/29237817/an-arf6-and-caveolae-dependent-pathway-links-hemidesmosome-remodeling-and-mechanoresponse
#7
Naël Osmani, Julien Pontabry, Jordi Comelles, Nina Fekonja, Jacky G Goetz, Daniel Riveline, Elisabeth Georges-Labouesse, Michel Labouesse
Hemidesmosomes (HDs) are epithelial-specific cell-matrix adhesions, which stably anchor the intracellular keratin network to the extracellular matrix. Although their main role is to protect the epithelial sheet from external mechanical strain, how HDs respond to mechanical stress remains poorly understood. Here we identify a pathway essential for HD remodeling, and outline its role with respect to α6β4 integrin recycling. We find that α6β4 integrin chains localize to the plasma membrane, caveolae and Arf6+ endocytic compartments...
December 13, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/29235694/calling-all-archaeologists-guidelines-for-terminology-methodology-data-handling-and-reporting-when-undertaking-and-reviewing-stable-isotope-applications-in-archaeology
#8
Patrick Roberts, Ricardo Fernandes, Oliver E Craig, Thomas Larsen, Alexandre Lucquin, Jillian Swift, Jana Zech
Stable isotope analysis has been utilized in archaeology since the 1970s, yet standardized protocols for terminology, sampling, pretreatment evaluation, calibration, quality assurance and control, data presentation, and graphical or statistical treatment still remain lacking in archaeological applications. Here, we present recommendations and requirements for each of these in the archaeological context of: bulk stable carbon and nitrogen isotope analysis of organics; bulk stable carbon and oxygen isotope analysis of carbonates; single compound stable carbon and nitrogen isotope analysis on amino acids in collagen and keratin; and single compound stable carbon and hydrogen isotope analysis on fatty acids...
December 13, 2017: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/29232767/a-comparative-immunohistochemical-study-of-anal-canal-epithelium-in-humans-and-swine-focusing-on-the-anal-transitional-zone-epithelium-and-the-anal-glands
#9
Futoshi Muranaka, Tomoyuki Nakajima, Mai Iwaya, Keiko Ishii, Kayoko Higuchi, Naoko Ogiwara, Shinichi Miyagawa, Hiroyoshi Ota
To better understand the cellular origins and differentiation of anal canal epithelial neoplasms, the immunohistochemical profiles of the anal canal epithelium in humans and swine were evaluated. Formalin-fixed tissue sections were immunostained for mucin (MUC: MUC2, MUC5AC, MUC5B), desmoglein 3 (DGS3), p63, CDX2, SOX2, and α-smooth muscle actin (α-SMA). The anal transitional zone (ATZ) epithelium covered the anal sinus and consisted of a stratified epithelium with mucous cells interspersed within the surface lining...
December 12, 2017: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/29229247/analysis-of-lecithin-treatment-effects-on-the-structural-transformation-of-wool-fiber-using-vibrational-spectroscopy
#10
Hossein Barani, Aminoddin Haji, Homa Maleki
The keratin macromolecule in wool fiber may be found in α-helix or β-sheet conformations besides a disordered portion. The physical and chemical treatments may cause transformations between α-helix and β-sheet conformations. The aim of this study was to investigate the influence of lecithin treatment on the wool fiber using the micro-Raman spectroscopy and Fourier transform infrared spectroscopy. Characteristic bands found in the FTIR spectra of wool fibers including the amide A, amide B and amide I-III, which are assigned to the peptide bonds of wool keratin and arise from the amide bonds that link the amino acids...
December 8, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29228570/keratin-8-reduces-colonic-permeability-and-maintains-gut-microbiota-homeostasis-protecting-against-colitis-and-colitis-associated-tumorigenesis
#11
Chao Liu, En-Dong Liu, Yun-Xiao Meng, Xiao-Ming Dong, Ya-Lan Bi, Huan-Wen Wu, Yan-Chao Jin, Ke Zhao, Jian-Jie Li, Miao Yu, Yi-Qun Zhan, Hui Chen, Chang-Hui Ge, Xiao-Ming Yang, Chang-Yan Li
Keratin 8 (CK8) is the major component of the intermediate filaments of simple or single-layered epithelia. Gene targeting mice model suggest that CK8 is involved in colonic active ion transport, colorectal hyperplasia and inflammation. In the present study, we found that CK8 is downregulated in the colon during DSS-induced colitis and AOM/DSS-induced colitis-associated colorectal cancer (CAC) development. In human patients with colon cancer, CK8 is downregulated. Using CK8 heterozygous knockout mice (CK8+/-), we found that CK8+/- mice are highly susceptible to DSS-induced colitis and more prone to AOM/DSS-induced CAC than wild type (WT) mice...
November 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/29227141/cervical-porcupine-quill-foreign-body-involving-the-spinal-cord-of-a-dog-a-description-of-various-imaging-modality-findings
#12
Christelle Le Roux, Frans J Venter, Robert M Kirberger
Although porcupine quill injuries are common in dogs, the detailed appearance of the quill on diagnostic ultrasound, computed tomography, and magnetic resonance imaging has not been sufficiently described. A 4-year-old, intact, female Jack Russel terrier presented with severe neck pain and ataxia after an altercation with a porcupine 2 weeks earlier. Radiology, diagnostic ultrasound, computed tomography and magnetic resonance imaging were all utilised to identify a quill imbedded in the cervical vertebral canal and cervical musculature and were compared to each other...
December 8, 2017: Journal of the South African Veterinary Association
https://www.readbyqxmd.com/read/29227042/ex-vivo-confocal-microscopy-features-of-cutaneous-squamous-cell-carcinoma
#13
Daniela Hartmann, Sebastian Krammer, Mario Raphael Bachmann, Leonie Mathemeier, Thomas Ruzicka, Isin Sinem Bagci, Tanja von Braunmühl
BACKGROUND: Rapid microscopic evaluation of cutaneous squamous cell carcinoma (SCC), its grade of differentiation and level of invasiveness would enable better management of patients' therapy. OBJECTIVES: Analyzing specific ex-vivo confocal microscopy criteria whether they can predict diagnosis of invasive SCC vs. carcinoma in situ and poorly differentiated or undifferentiated vs. well and moderately differentiated SCC. METHODS: Ex-vivo confocal images of 102 SCCs in 57 patients were evaluated immediately after excision for the presence of predefined criteria based on confocal and histological knowledge...
December 11, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/29226584/wool-derived-keratin-hydrogel-enhances-implant-osseointegration-in-cancellous-bone
#14
Warwick J Duncan, Philippa F C Greer, Min-Ho Lee, Carolina Loch, Jennifer H A Gay
AIM: This study investigated whether a keratin hydrogel derived from wool enhances ossointegration of dental implants, using a cancellous bone model in sheep. METHOD: Ten female sheep received one dental implant per hind leg in the distal femoral condyles. Test implants were coated with 1 mL of keratin hydrogel containing sulphonated keratin and hydroxyapatite; control implants remained uncoated; implants were not functionally loaded axially. Biomechanical stability was tested with resonance frequency analysis (RFA) at placement and euthanasia...
December 11, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29226422/pathogenesis-of-psoriasis-and-development-of-treatment
#15
REVIEW
Eisaku Ogawa, Yuki Sato, Akane Minagawa, Ryuhei Okuyama
The pathogenesis of psoriasis can be explained by dysregulation of immunological cell function as well as keratinocyte proliferation/differentiation. Recently, the immunological pathomechanism has been clarified substantially. Whereas T-helper (Th)1 overactivation was thought to induce occurrence of psoriasis, it has been demonstrated that Th17 cells play a key role. Th17 development is maintained by interleukin (IL)-23 mainly produced by dendritic cells. Th17 cells produce various cytokines, including IL-17A, IL-17F and IL-22...
December 10, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/29223756/microneedles-a-versatile-strategy-for-transdermal-delivery-of-biological-molecules
#16
REVIEW
Dong-Jin Lim, Jeremy B Vines, Hansoo Park, Soo-Hong Lee
Human skin is made up of multiple layers and is designed to protect the human body. The stratum corneum (SC), specifically, is a keratinized layer of skin through which molecules heavier than 500Da cannot penetrate. Traditional methods of transdermal drug delivery through the SC, such as hypodermic needles, are less than ideal because their size and appearance can cause fear and pain, creating hesitation, limiting self-administration, and preventing their use in some patients altogether. A new technology has been developed to address these limitations, in which an array of needles, each microns in diameter and length, called microneedles, are able to pierce the skin's SC to deliver therapeutic agents without stimulating the proprioceptive pain nerves...
December 6, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29222809/effect-of-abutment-height-on-interproximal-implant-bone-level-in-the-early-healing-a-randomized-clinical-trial
#17
Juan Blanco, Alexandre Pico, Leticia Caneiro, Lourdes Nóvoa, Pilar Batalla, Pablo Martín-Lancharro
OBJECTIVE: The aim of this randomized clinical trial was to compare the effect on the interproximal implant bone loss (IBL) of two different heights (1 and 3 mm) of definitive abutments placed at bone level implants with a platform switched design. MATERIAL AND METHODS: Twenty-two patients received forty-four implants (6.5-10 mm length and 3.5-4 mm diameter) to replace at least two adjacent missing teeth, one bridge set to each patient-two implants per bridge...
December 8, 2017: Clinical Oral Implants Research
https://www.readbyqxmd.com/read/29220096/hepatic-progenitor-cells-in-metastatic-liver-carcinomas
#18
Ioanna Delladetsima, Stratigoula Sakellariou, Olivier Govaere, Elpida Poulaki, Evangelos Felekouras, Dina Tiniakos
AIMS: Hepatic progenitor cells (HPCs) are activated in various liver diseases but their role in carcinomatous environment remains unknown. We aimed to identify the possible presence and topography of HPCs in liver metastases. METHODS: We examined 14 liver resection specimens for colorectal adenocarcinoma (CRC) (n=13) and anal squamous cell carcinoma (SCC) (n=1) metastases. Immunohistochemical markers of colonic (keratin 20-K20, CDX2) and squamous cell origin (p63), HPC (K19, CD56) and stem cell (CD44) markers, and the biliary marker K7 which may also highlight HPCs were applied on routinely processed tissue sections...
December 8, 2017: Histopathology
https://www.readbyqxmd.com/read/29218735/soft-tissue-regrowth-after-osseous-resective-surgery-with-and-without-fibre-retention-technique-four-year-follow-up-of-a-randomized-clinical-trial
#19
Mario Aimetti, Giulia Maria Mariani, Elena Ercoli, Martina Audagna, Federica Romano
AIM: The aim of this study was to compare the clinical outcomes and soft-tissue rebound following Fibre Retention Osseous Resective Surgery (FibReORS) and Osseous Resective Surgery (ORS) over a 48-month period. MATERIALS AND METHODS: Thirteen chronic periodontitis patients, displaying two contralateral posterior sextants with residual intrabony defects ≤ 3 mm in single-rooted or multi-rooted teeth with no or grade I furcation involvement, were treated in a split-mouth study model...
December 8, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/29217752/mapping-the-distribution-of-stem-progenitor-cells-across-the-middle-ear-during-homeostasis-and-inflammation
#20
Abigail S Tucker, Carlene J Dyer, Juan M Fons Romero, Tathyane H N Teshima, Jennifer C Fuchs, Hannah Thompson
The middle ear epithelium is derived from neural crest and endoderm, which line distinct regions of the middle ear cavity. Here we investigate the distribution of putative stem cell markers in the middle ear combined with an analysis of the location of label retaining cells (LRCs) to create a map of the middle ear mucosa. We show that proliferating cells and LRCs were associated with specific regions of the ear epithelium, concentrated in the hypotympanum at the base of the auditory bulla and around the ear drum...
December 7, 2017: Development
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