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https://www.readbyqxmd.com/read/29028846/periodontal-indices-and-status-in-34-growing-patients-with-unilateral-cleft-lip-and-palate-a-split-mouth-study
#1
Paweł Plakwicz, Beata Wyrębek, Renata Górska, Dorota Cudziło
Periodontal examination in growing patients with unilateral cleft lip and palate was performed in a split-mouth study design. Higher plaque acumulation and bleeding indices were recorded for teeth on the cleft side. Pocket probing depth (PPD) and clinical attachment level (CAL) values were higher at lateral incisors and canines adjacent to the cleft. Keratinized gingiva and depth of the vestibule were lower adjacent to the cleft. This study shows that growing patients with clefts present differences regarding periodontal parameters between the cleft and the control side...
November 2017: International Journal of Periodontics & Restorative Dentistry
https://www.readbyqxmd.com/read/29028840/polymorphism-of-keratin-1-associates-with-systemic-lupus-erythematosus-and-systemic-sclerosis-in-a-south-chinese-population
#2
Weiguang Luo, Bin Zhou, Qizhi Luo, Huilong Fang, Xiaoxia Zuo, Yizhou Zou
Both systemic lupus erythematosus (SLE) and systemic sclerosis (SSc) diseases are related to the genetic and environmental factors, causing damage to the skin. The mutations of keratin 1 gene (KRT1) were reported to associate with skin diseases. The single-nucleotide polymorphism (SNP, rs14024) and the indel polymorphism (cds-indel, rs267607656), consisting mostly of the common haplotypes and could be used for genotyping of KRT1. We used the PCR with sequence specific primers (PCR-SSP) to determine the genotype of KRT1 in 164 SLE, 99 SSc patients, and 418 healthy controls...
2017: PloS One
https://www.readbyqxmd.com/read/29027377/contribution-of-extracellular-matrix-and-signal-mechanotransduction-to-epithelial-cell-damage-in-inflammatory-bowel-disease-patients-a-proteomic-study
#3
Manuela Moriggi, Luca Pastorelli, Enrica Torretta, Gian Eugenio Tontini, Daniele Capitanio, Stefano Ferrero Bogetto, Maurizio Vecchi, Cecilia Gelfi
This study utilized 2D-DIGE, isotope-coded protein labelling (ICPL) and biochemical assays to characterize protein alteration in Ulcerative Colitis (UC) and Crohn's Disease (CD) in human epithelial cell and mucosal biopsies in Inflammatory Bowel Disease (IBD)-affected patients. The aim of this study is to identify the key molecular signatures involved in epithelial cell structure of IBDs. In non-inflamed UC (QUC) keratins, vimentin and FAK increased, whereas vinculin and de-tyrosinated α-tubulin decreased; inflammation (IUC) exacerbated molecular changes, being COL6A1, tenascin-C and vimentin increased...
October 13, 2017: Proteomics
https://www.readbyqxmd.com/read/29026647/progress-in-development-of-bioderived-materials-for-dermal-wound-healing
#4
REVIEW
Lin-Cui Da, Yi-Zhou Huang, Hui-Qi Xie
Treatment of acute and chronic wounds is one of the primary challenges faced by doctors. Bioderived materials have significant potential clinical value in tissue injury treatment and defect reconstruction. Various strategies, including drug loading, addition of metallic element(s), cross-linking and combining two or more distinct types of materials with complementary features, have been used to synthesize more suitable materials for wound healing. In this review, we describe the recent developments made in the processing of bioderived materials employed for cutaneous wound healing, including newly developed materials such as keratin and soy protein...
October 2017: Regenerative Biomaterials
https://www.readbyqxmd.com/read/29023872/cell-death-markers-in-cirrhotic-patients-with-acute-decompensation
#5
Stewart Macdonald, Fausto Andreola, Patrik Bachtiger, Alex Amoros, Marco Pavesi, Rajeshwar Mookerjee, Yu Bao Zheng, Henning Grønbaek, Alexander L Gerbes, Elsa Sola, Paolo Caraceni, Richard Moreau, Pere Gines, Vicente Arroyo, Rajiv Jalan
The aims of this study were to determine the role of cell death in cirrhotic patients with acute decompensation (AD) and acute on chronic liver failure (ACLF) using plasma-based biomarkers. The patients studied were part of the CANONIC study (N=337; AD: 258; ACLF: 79); additional cohorts included healthy volunteers, stable cirrhotic patients and a group of 16 AD patients for histological studies. Caspase-cleaved keratin 18 (cK18) and keratin 18 (K18), which reflect apoptotic and total cell death respectively and cK18:K18 ratio (apoptotic index) were measured in the plasma by ELISA...
October 10, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29023690/the-bony-horncore-of-the-common-eland-taurotragus-oryx-composition-and-mechanical-properties-of-a-spiral-fighting-structure
#6
Jamil Cappelli, Andrés J García, Radim Kotrba, Pablo Gambín Pozo, Tomas Landete-Castillejos, Laureano Gallego, Francisco Ceacero
Horns are permanent structures projecting from the head of bovids, consisting of a bony horncore covered with a layer of skin and then a sheath of keratinous material showing variability of growth intensity based on nutrition. From the point of view of the horn's mechanical properties, the keratin sheath has been widely studied, but only a few studies have considered the complete structure of the horn and fewer studies have focused on the bony horncore and its characteristics. The latter showed the important role of the bony core, when cranial appendages are subject to mechanical stress (as happens during fighting)...
October 10, 2017: Journal of Anatomy
https://www.readbyqxmd.com/read/29023624/two-year-clinical-evaluation-of-pedicled-buccal-fat-pad-alone-and-with-emdogain-for-root-coverage-of-severe-gingival-recession-defects-a-case-series
#7
Sally Abd-ElMeniem El-Haddad, Mohammad Abd-ElHakeem El-Shall
Gingival recession is defined as an apical displacement of the gingival margin beyond the cementoenamel junction leading to serious consequences, including exposure of the root surface, loss of periodontal attachment, root sensitivity to hot and cold air, and esthetic problems. The aim of this study was to evaluate the long-term effect of pedicled buccal fat pad (PBFP) alone and with Emdogain in covering severe gingival recession defects and restoring tooth function. A total of 10 severe buccal recession defects in maxillary first molars were selected to be treated with PBFP, with Emdogain (group I; n = 5) or alone (group II; n = 5)...
2017: International Journal of Periodontics & Restorative Dentistry
https://www.readbyqxmd.com/read/29018015/chronic-red-eye-a-masquerade-of-advanced-neoplastic-disease
#8
Joana Providência, Filipa Ponces, Guilherme Castela, Joaquim Murta
A 42-year-old woman presented with chronic history of left red eye for more than 12 months, treated with difference topical medication but without response. Ocular external examination demonstrated a firm palpable mass in the medial portion of the lower eyelid and slit-lamp evaluation of the lesion showed an ulcerated conjunctival nodule, keratin secretor. CT of the orbits revealed left-sided orbital mass located anteriorly, inferiorly and medially in the orbit, adjacent to the globe and orbit walls. Incisional biopsy of the lesion was consistent with invasive squamous cell carcinoma of the conjunctiva...
October 10, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28992039/environmental-causation-of-turtle-scute-anomalies-in-ovo-and-in-silico
#9
Roland Zimm, Blair P Bentley, Jeanette Wyneken, Jacqueline E Moustakas-Verho
The turtle shell is often described as an evolutionary novelty that facilitated the radiation of the clade Testudines. The scutes, or keratinous plates, of the turtle shell are hypothesized to be patterned by reaction-diffusion dynamics, and this property of their development provides explanatory power to mechanisms of anomalous variation. A mathematical model of scute development predicts that anomalous variation in the phylogenetically stable pattern of scutes is achieved by environmental influence on the developmental program...
July 25, 2017: Integrative and Comparative Biology
https://www.readbyqxmd.com/read/28990126/effectiveness-and-predictability-of-titanium-prepared-platelet-rich-fibrin-for-the-management-of-multiple-gingival-recessions
#10
Bilge Cansu Uzun, Esra Ercan, Mustafa Tunalı
OBJECTIVE: Titanium-prepared platelet-rich fibrin (T-PRF) is activated with titanium, which results in a more mature and aggregated form than PRF. In our previous studies, we established that the fibrin carpet formed with titanium had a firmer network structure, and longer resorption time in the tissue than the fibrin carpet formed with glass. The purpose of this randomized controlled clinical trial is to compare the effects of autogenous T-PRF and connective tissue graft (CTG). MATERIALS AND METHODS: A total of 114 Miller Class I/II gingival recessions with abrasion defects were treated either T-PRF (63 teeth) or CTG (51 teeth) using a modified tunnel technique...
October 8, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28983467/ultrastructural-changes-during-the-life-cycle-of-mycoplasma-salivarium-in-oral-biopsies-from-patients-with-oral-leukoplakia
#11
Harumi Mizuki, Ryosuke Abe, Toshinari Mikami
Bacteria in genus Mycoplasma spp. are the smallest and simplest form of freely replicating bacteria, with 16 species known to infect humans. In the mouth, M. salivarium is the most frequently identified species. Mycoplasma spp. are parasites with small genomes. Although most of the Mycoplasma spp. that infect humans remain attached to the host cell surface throughout their life cycle, we have previously reported the presence of Mycoplasma salivarium in the epithelial cells of oral leukoplakia and oral lichen planus...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28982683/mechanical-and-signaling-roles-for-keratin-intermediate-filaments-in-the-assembly-and-morphogenesis-of-mesendoderm-tissue-at-gastrulation
#12
Pooja R Sonavane, Chong Wang, Bette Dzamba, Gregory F Weber, Ammasi Periasamy, Douglas W DeSimone
Coordination of individual cell behaviors is a critical step in the assembly and morphogenesis of tissues. Xenopus mesendoderm cells migrate collectively along a fibronectin (FN) substrate at gastrulation but how the adhesive and mechanical forces required for these movements are generated and transmitted is unclear. Traction force microscopy (TFM) was used to establish that traction stresses are limited primarily to leading edge cells in mesendoderm explants and that these forces are balanced by intercellular stresses in follower rows...
October 5, 2017: Development
https://www.readbyqxmd.com/read/28980535/the-nail-as-an-investigative-tool-in-medicine-what-a-dermatologist-ought-to-know
#13
REVIEW
Chander Grover, Shikha Bansal
The nail is an important skin appendage, but not many dermatologists are aware of the importance it receives outside our specialty. This article focuses on the nail in non-dermatological contexts. The nail is a keratinized matrix capable of continuous growth with the ability to incorporate various compounds within its structure. Therefore it can be used to monitor long-term consumption of drugs. It is also an excellent source of germ-line DNA for genetic analyses. With an increased undrstanding of nail physiology, there is now a better understanding of its connection to various pathologies as well...
October 4, 2017: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/28979865/a-prospective-study-of-clinical-profile-in-patients-of-palmoplantar-dermatoses
#14
Pragya A Nair, Nilofar G Diwan, Rochit Singhal, Rita V Vora
BACKGROUND: Palms and soles are the readily visible areas of the body that are affected in various dermatoses. This may have considerable concern to the patient and can cause diagnostic dilemma. Moreover, palmoplantar dermatoses also limit our day to day activities with a significant impact on quality of life. AIM: To study the clinical profile of patients suffering from palmoplantar dermatoses at a tertiary care centre. PATIENTS AND METHODS: A prospective observational study was carried out from June 2014 to May 2015 in the Department of Dermatology, Venerology and Leprosy at a rural tertiary care centre after taking approval from the institutional ethical committee...
September 2017: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/28978728/novel-and-divergent-genes-in-the-evolution-of-placental-mammals
#15
Thomas L Dunwell, Jordi Paps, Peter W H Holland
Analysis of genome sequences within a phylogenetic context can give insight into the mode and tempo of gene and protein evolution, including inference of gene ages. This can reveal whether new genes arose on particular evolutionary lineages and were recruited for new functional roles. Here, we apply MCL clustering with all-versus-all reciprocal BLASTP to identify and phylogenetically date 'Homology Groups' among vertebrate proteins. Homology Groups include new genes and highly divergent duplicate genes. Focusing on the origin of the placental mammals within the Eutheria, we identify 357 novel Homology Groups that arose on the stem lineage of Placentalia, 87 of which are deduced to play core roles in mammalian biology as judged by extensive retention in evolution...
October 11, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/28974924/regulatory-pathway-analysis-of-coat-color-genes-in-mongolian-horses
#16
Bei Li, Xiaolong He, Yiping Zhao, Dongyi Bai, Wunierfu Shiraigo, Qinan Zhao, Dugarjaviin Manglai
BACKGROUND: Studies on the molecular genetics of horse skin pigmentation have typically focused on very few genes and proteins. In this study, we used Illumina sequencing to determine the global gene expression profiles in horses with white-colored coats and those with black-colored coats, with the goal of identifying novel genes that could regulate horse coat color. RESULTS: Genes encoding ribosomal-associated proteins were highly expressed in horse skin. We found a total of 231 unigenes that were differentially expressed between horses with white coats and horses with black coats; 119 were down-regulated, and 112 were up-regulated...
2018: Hereditas
https://www.readbyqxmd.com/read/28974475/hierarchical-structure-and-compressive-deformation-mechanisms-of-bighorn-sheep-ovis-canadensis-horn
#17
Wei Huang, Alireza Zaheri, Jae-Young Jung, Horacio D Espinosa, Joanna Mckittrick
Bighorn sheep (Ovis canadensis) rams hurl themselves at each other at speeds of ∼9 m/s (20 mph) to fight for dominance and mating rights. This necessitates impact resistance and energy absorption mechanisms, which stem from material-structure components in horns. In this study, the material hierarchical structure as well as correlations between the structure and mechanical properties are investigated. The major microstructural elements of horns are found as tubules and cell lamellae, which are oriented with (∼30⁰) angle with respect to each other...
September 30, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28973883/heterochronic-truncation-of-odontogenesis-in-theropod-dinosaurs-provides-insight-into-the-macroevolution-of-avian-beaks
#18
Shuo Wang, Josef Stiegler, Ping Wu, Cheng-Ming Chuong, Dongyu Hu, Amy Balanoff, Yachun Zhou, Xing Xu
Beaks are innovative structures characterizing numerous tetrapod lineages, including birds, but little is known about how developmental processes influenced the macroevolution of these important structures. Here we provide evidence of ontogenetic vestigialization of alveoli in two lineages of theropod dinosaurs and show that these are transitional phenotypes in the evolution of beaks. One of the smallest known caenagnathid oviraptorosaurs and a small specimen of the Early Cretaceous bird Sapeornis both possess shallow, empty vestiges of dentary alveoli...
September 25, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28973874/why-pens-have-rubbery-grips
#19
Brygida Dzidek, Séréna Bochereau, Simon A Johnson, Vincent Hayward, Michael J Adams
The process by which human fingers gives rise to stable contacts with smooth, hard objects is surprisingly slow. Using high-resolution imaging, we found that, when pressed against glass, the actual contact made by finger pad ridges evolved over time following a first-order kinetics relationship. This evolution was the result of a two-stage coalescence process of microscopic junctions made between the keratin of the stratum corneum of the skin and the glass surface. This process was driven by the secretion of moisture from the sweat glands, since increased hydration in stratum corneum causes it to become softer...
September 25, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28971628/comparative-three-dimensional-morphology-of-baleen-cross-sectional-profiles-and-volume-measurements-using-ct-images
#20
Megan M Jensen, Amalia H Saladrigas, Jeremy A Goldbogen
Baleen whales are obligate filter feeders, straining prey-laden seawater through racks of keratinized baleen plates. Despite the importance of baleen to the ecology and natural history of these animals, relatively little work has been done on baleen morphology, particularly with regard to the three-dimensional morphology and structure of baleen. We used computed tomography (CT) scanning to take 3D images of six baleen specimens representing five species, including three complete racks. With these images, we described the three-dimensional shape of the baleen plates using cross-sectional profiles from within the gum tissue to the tip of the plates...
November 2017: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
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