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https://www.readbyqxmd.com/read/29788984/f-18-fdg-pet-ct-in-26-patients-with-sapho-syndrome-a-new-vision-of-clinical-and-bone-scintigraphy-correlation
#1
Xiaochuan Sun, Chen Li, Yihan Cao, Ximin Shi, Li Li, Weihong Zhang, Xia Wu, Nan Wu, Hongli Jing, Wen Zhang
BACKGROUNDS: Whole-body bone scintigraphy (WBBS) and MRI are widely used in assessment of patients with synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome. However, the value of F-18 fluorodeoxyglucose-positron emission tomography/computed tomography (18 F-FDG PET/CT) in SAPHO syndrome was unclear. The aim of this study was to characterize the manifestation of SAPHO syndrome on 18 F-FDG PET/CT and explore its relationship with clinical symptoms and WBBS. METHODS: Twenty-six patients who suffered from SAPHO syndrome and had undergone whole-body 18 F-FDG PET/CT were recruited in Peking Union Medical College Hospital from 2004 to 2016...
May 22, 2018: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29786933/acute-generalized-exanthematous-pustulosis-due-to-terbinafine
#2
Casey L Ross, Alina Shevchenko, Nicholas K Mollanazar, Sylvia Hsu, Kiran Motaparthi
Acute generalized exanthematous pustulosis is a rare adverse cutaneous reaction characterized by the rapid appearance of numerous pustules arising on edematous, erythematous skin. It is commonly accompanied by fever and leukocytosis and usually resolves with discontinuation of the offending agent. Herein, acute generalized exanthematous pustulosis induced by terbinafine is described, followed by a brief review of the literature.
May 21, 2018: Dermatologic Therapy
https://www.readbyqxmd.com/read/29782303/clindamycin-induced-maculopapular-exanthema-with-preferential-involvement-of-striae-distensae-a-koebner-phenomenon
#3
Benigno Monteagudo, Miguel Cabanillas, Pilar Iriarte, Aquilina Ramírez-Santos, Elvira León-Muinos, Daniel González-Vilas, Óscar Suárez-Amor
Clindamycin is a lincomycin-derived antibiotic useful for the treatment of anaerobic and Gram-positive aerobic bacterial infections. Cutaneous adverse reactions are usually maculopapular exanthemas, although hypersensitivity syndrome, acute generalized exanthematous pustulosis, and Stevens-Johnson syndrome have also been reported (1). We report the case of a patient with a maculopapular rash triggered by clindamycin who developed cutaneous lesions on striae distensae (SD). A 47-year-old woman was referred to our clinic for pruritic cutaneous lesions which had started 6 days earlier...
April 2018: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/29755804/sapho-syndrome-masquerading-as-metastatic-breast-cancer
#4
Devin Malik, Richa Handa, Andrew Petraszko, Sheela Tejwani
SAPHO syndrome is a rare clinical entity composed of synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO). We describe a case of SAPHO syndrome masquerading as metastatic breast cancer in a patient with localized breast cancer who presented with cord compression. There was no pathologic evidence of metastatic cancer; however, a bone scan indicated osseous involvement. After multidisciplinary review of images and with additional findings of pustulosis and acne, a clinical diagnosis of SAPHO was made...
2018: Case Reports in Rheumatology
https://www.readbyqxmd.com/read/29743324/spondyloarthritis-in-the-democratic-republic-of-the-congo-a-prospective-hospital-based-study
#5
Pierrot Lebughe, Kurt de Vlam, Rene Westhovens, Jean-Marie Mbuyi-Muamba, Jean Jacques Malemba
OBJECTIVES: To determine the spectrum of spondyloarthritis (SpA) in outpatients with symptoms of rheumatism attending two rheumatology practices in the Democratic Republic of the Congo. DESIGN: A descriptive prospective multicentre outpatient study. SETTING: The present study analysed 6 months data (from 1 December 2012 till 31 May 2013). PARTICIPANTS: Nine hundred and eighty-four consecutive outpatients were studied...
May 9, 2018: BMJ Open
https://www.readbyqxmd.com/read/29732605/treatment-outcome-and-prognostic-factors-of-tonsillectomy-for-palmoplantar-pustulosis-and-pustulotic-arthro-osteitis-a-retrospective-subjective-and-objective-quantitative-analysis-of-138-patients
#6
Miki Takahara, Yui Hirata, Toshihiro Nagato, Kan Kishibe, Akihiko Katada, Tatsuya Hayashi, Mari Kishibe, Akemi Ishida-Yamamoto, Yasuaki Harabuchi
Pustulosis palmaris et plantaris (PPP) and pustulotic arthro-osteitis (PAO) are tonsil-related diseases. Treatment outcome of tonsillectomy and prognostic factors influencing the outcome have not been analyzed quantitatively. We evaluated those using the Palmoplantar Pustulosis Area and Severity Index (PPPASI). At 1, 3, 6, 12, 24 and more than 24 months post-tonsillectomy, 20 (31%), 34 (48%), 70 (60%), 57 (80%), 36 (95%) and 23 (96%) patients realized 80% or more improvement of PPP skin lesions, respectively, and eight (17%), 23 (36%), 30 (50%), 38 (79%), 12 (100%) and four (100%) patients showed 80% or more improvement of PPPASI (i...
May 6, 2018: Journal of Dermatology
https://www.readbyqxmd.com/read/29703869/a-10-years-retrospective-study-on-severe-cutaneous-adverse-reactions-scars-in-a-tertiary-hospital-in-penang-malaysia
#7
C H Loo, W C Tan, Y H Khor, L C Chan
INTRODUCTION: Severe cutaneous adverse drug reactions (SCARs) are not uncommon and potentially lifethreatening. Our objective is to study the patient characteristics, the pattern of implicated drugs and treatment outcome among patients with SCARs. METHODS: A 10-year retrospective analysis of SCARs cases in Penang General Hospital was carried out from January 2006 to December 2015. Data collection is based on the Malaysian Adverse Drug Reactions Advisory Committee registry and dermatology clinic records...
April 2018: Medical Journal of Malaysia
https://www.readbyqxmd.com/read/29694253/serum-levels-of-proinflammatory-antiinflammatory-cytokines-and-rankl-opg-in-synovitis-acne-pustulosis-hyperostosis-and-osteitis-sapho-syndrome
#8
Shuo Zhang, Chen Li, Siya Zhang, Li Li, Weihong Zhang, Zhenhua Dong, Wen Zhang
Objective To measure the expression of proinflammatory, antiinflammatory cytokines, and RANKL/OPG in SAPHO Syndrome, and to assess the relationship between those factors and disease activity. Methods We studied 30 cases of SAPHO syndrome and 15 healthy controls. According to the visual analogue scale pain scores and Bath ankylosing spondylitis activity index, patients were divided into active group and stable group. The serum levels of IFN-γ, TNF-α, TGF-β1, IL-1β, IL-4, IL-6, IL-8, IL-17A, IL-22, receptor activator NK-κB ligand (RANKL) and osteoprotegerin (OPG) were determined by ELISA...
April 25, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29681837/unusual-case-of-vogt-koyanagi-harada-disease-associated-with-sapho-syndrome-a-case-report
#9
Miyuki Hasegawa, Akira Fukutomi, Akiko Jinno, Kyoko Fujita, Motohiro Kamei
A 66-year-old Japanese woman who was diagnosed with synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) syndrome presented with bilateral blurred vision 4 months prior to visiting our hospital. She had visited a local ophthalmology clinic first. She was diagnosed with conjunctivitis and was prescribed antibacterial eye drops. The symptoms persisted in spite of treatment. She was then referred to our hospital. At her initial visit, the visual acuities were 0.6 in both eyes. A slit-lamp examination revealed bilateral shallow anterior chamber, and intraocular pressures of 18 mm Hg in the right eye and 16 mm Hg in the left eye...
January 2018: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/29681811/a-case-of-ceftriaxone-induced-acute-generalized-exanthematous-pustulosis-generalized-pustular-psoriasis-overlap
#10
Jianfeng Zheng, Yunlu Gao, Xuemei Yi, Yangfeng Ding
Acute generalized exanthematous pustulosis, characterized by subcorneal or superficial intraepidermal pustules, is induced by drugs in more than 90% of cases. Psoriasis is an autoimmune disease triggered by different conditions in genetically susceptible people. Generalized pustular psoriasis is an acute and severe clinical form of psoriasis, which usually occurs in patients with psoriasis undergoing aggravating factors. In this report the authors have reported a 40-year-old male patient with primary syphilis who developed generalized pustular dermatosis after the use of ceftriaxone...
January 2018: Case Reports in Dermatology
https://www.readbyqxmd.com/read/29681595/remission-of-palmoplantar-pustulosis-after-on-pump-coronary-artery-bypass-grafting-in-a-patient-with-titanium-allergy
#11
Takanori Kono, Takeshi Oda, Keiichi Akaiwa, Katsuhiko Nakamura, Kenya Sasaoka, Hiroyuki Tanaka
Metal allergy is an uncommon problem during surgery. Among them, titanium allergy is said to be rare, but can lead to serious complications, such as palmoplantar pustulosis (PPP). A 69-year-old woman was admitted to our hospital with a chief complaint of chest pain. Coronary angiography showed severe coronary artery disease that required coronary artery bypass grafting (CABG). The patient had a history of orthopedic surgery for left distal radius fracture 2 years previously, which resulted in inflammation on the left arm and PPP...
April 20, 2018: Annals of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29672809/sapho-and-crmo-the-value-of-imaging
#12
Anne Grethe Jurik, Rikke Fuglsang Klicman, Paolo Simoni, Philip Robinson, James Teh
The syndromes synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) and chronic recurrent multifocal osteomyelitis (CRMO) constitute a group of chronic relapsing inflammatory osteoarticular disorders with frequently associated skin eruptions such as palmoplantar pustulosis and acne conglobata and rather characteristic imaging features in the form of osteitis and/or hyperostosis. CRMO predominantly occurs in children/adolescents and SAPHO in adults. Any skeletal site can be involved, and the imaging appearances vary, depending on the patient's age and the stage/age of the lesion...
April 2018: Seminars in Musculoskeletal Radiology
https://www.readbyqxmd.com/read/29611085/paradoxical-skin-lesions-induced-by-anti-tnf-%C3%AE-agents-in-sapho-syndrome
#13
Chen Li, Xia Wu, Yihan Cao, Yueping Zeng, Weihong Zhang, Shuo Zhang, Yuehua Liu, Hongzhong Jin, Wen Zhang, Li Li
The objectives of the study were to characterize the clinical picture of paradoxical skin lesions in SAPHO patients treated with anti-TNF-α agents and to explore its pathogenesis. Patients treated with anti-TNF-α therapy were identified from a cohort of 164 SAPHO patients. The clinical data and skin biopsies were collected. The usage, efficacy, and side effects of anti-TNF-α therapy were recorded. Forty-one (25.0%) patients received anti-TNF-α therapy, of which seven (17.1%) developed paradoxical skin lesions after 1 to 14 infusions...
April 3, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29600537/hyper-immunoglobulin-d-syndrome-with-novel-mutations-in-an-afebrile-infant
#14
Simi D Cadmus, Reid Green, Ruy Carrasco, Moise L Levy, Lucia Z Diaz
Hyper-immunoglobulin D syndrome is a rare autosomal-recessive autoinflammatory syndrome in which a mevalonate kinase deficiency results due to mutations of the mevalonate kinase gene. We report a case of an Asian male infant who was found to have hyper-immunoglobulin D syndrome in the absence of fever. His skin manifestations included cephalic pustulosis as well recurrent transient and fixed pink plaques and nodules on the face and extremities. Subsequent examination revealed hyper-immunoglobulin D syndrome with two novel allelic mutations in the mevalonate kinase gene: c...
March 30, 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29596638/the-multifaceted-presentation-of-chronic-recurrent-multifocal-osteomyelitis-a-series-of-486-cases-from-the-eurofever-international-registry
#15
Hermann Girschick, Martina Finetti, Francesca Orlando, Susanne Schalm, Antonella Insalaco, Gerd Ganser, Susan Nielsen, Troels Herlin, Isabelle Koné-Paut, Silvana Martino, Marco Cattalini, Jordi Anton, Sulaiman Mohammed Al-Mayouf, Michael Hofer, Pierre Quartier, Christina Boros, Jasmin Kuemmerle-Deschner, Denise Pires Marafon, Maria Alessio, Tobias Schwarz, Nicolino Ruperto, Alberto Martini, Annette Jansson, Marco Gattorno
Objectives: Chronic non-bacterial osteomyelitis (CNO) or chronic recurrent multifocal osteomyelitis (CRMO) is an autoinflammatory disorder characterized by sterile bone osteolytic lesions. The aim of this study was to evaluate the demographic data and clinical, instrumental and therapeutic features at baseline in a large series of CNO/CRMO patients enrolled in the Eurofever registry. Methods: A web-based registry collected retrospective data on patients affected by CRMO/CNO...
March 27, 2018: Rheumatology
https://www.readbyqxmd.com/read/29576189/alopecia-areata-and-palmoplantar-pustulosis-report-of-4-cases
#16
T Hiraiwa, T Yamamoto
No abstract text is available yet for this article.
March 22, 2018: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/29574562/severe-cutaneous-adverse-drug-reactions-presentation-risk-factors-and-management
#17
REVIEW
S Shahzad Mustafa, David Ostrov, Daniel Yerly
PURPOSE OF STUDY: Immune-mediated adverse drug reactions occur commonly in clinical practice and include mild, self-limited cutaneous eruptions, IgE-mediated hypersensitivity, and severe cutaneous adverse drug reactions (SCAR). SCARs represent an uncommon but potentially life-threatening form of delayed T cell-mediated reaction. The spectrum of illness ranges from acute generalized exanthematous pustulosis (AGEP) to drug reaction with eosinophilia with systemic symptoms (DRESS), to the most severe form of illness, Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN)...
March 24, 2018: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/29572854/acute-generalized-exanthematous-pustulosis-caused-by-ibuprofen-diagnosis-confirmed-by-patch-testing
#18
Doreen Belz, Oana D Persa, Stefan Haese, Nicolas Hunzelmann
No abstract text is available yet for this article.
March 24, 2018: Contact Dermatitis
https://www.readbyqxmd.com/read/29546340/post-smallpox-vaccination-skin-eruption-in-a-marine
#19
Todd R Kramer
This case report examines a vesiculopustular reaction which occurred in a young Marine 9 d after receiving the smallpox vaccination. Review of the CDC guidelines, ACAM2000 package insert, and literature surrounding the smallpox vaccine reveals several well-established adverse cutaneous reactions associated with vaccination. These dermatologic reactions are typically mild and self-limited, but do have the potential to be life threatening - especially in those with immunocompromise. Unfortunately, the correct diagnosis can often be difficult to make, as many of these rashes share similar characteristics...
March 13, 2018: Military Medicine
https://www.readbyqxmd.com/read/29531495/pustulotic-arthro-osteitis-sonozaki-syndrome-a-case-report-and-review-of-literature
#20
Reyhan Kose, Taskin Senturk, Gokhan Sargin, Songul Cildag, Yasemin Kara
Pustulotic arthro-osteitis (PAO) is a rare chronic inflammatory disease, which has now been classified as a seronegative spondyloarthritis. The sternoclavicular and sternocostal joints, pelvis, vertebra, hip, and long bones are affected. Skin findings of the disease are accepted as a variant of pustular psoriasis, but some authors have suggested that palmoplantar pustulosis (PPP) is a different entity. The synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome should be considered in the differential diagnosis...
February 2018: Eurasian Journal of Medicine
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