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https://www.readbyqxmd.com/read/28223770/infliximab-for-treatment-of-synovitis-acne-pustulosis-hyperostosis-and-osteitis-syndrome-a-case-report
#1
Ayaki Hirohata, Takaaki Hanafusa, Tomoko Kawamoto, Ryuta Ikegami
No abstract text is available yet for this article.
February 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/28203363/an-exploratory-factor-analysis-of-the-spontaneous-reporting-of-severe-cutaneous-adverse-reactions
#2
Manfred Hauben, Eric Hung, Wen-Yaw Hsieh
BACKGROUND: Severe cutaneous adverse reactions (SCARs) are prominent in pharmacovigilance (PhV). They have some commonalities such as nonimmediate nature and T-cell mediation and rare overlap syndromes have been documented, most commonly involving acute generalized exanthematous pustulosis (AGEP) and drug rash with eosinophilia and systemic symptoms (DRESS), and DRESS and toxic epidermal necrolysis (TEN). However, they display diverse clinical phenotypes and variations in specific T-cell immune response profiles, plus some specific genotype-phenotype associations...
January 2017: Therapeutic Advances in Drug Safety
https://www.readbyqxmd.com/read/28196316/common-skin-conditions-in-children-neonatal-skin-lesions
#3
Brian Z Rayala, Dean S Morrell
Skin findings during the initial month of life are ubiquitous. One study estimated that more than 95% of newborns have cutaneous findings, which often are distressing to parents but frequently are benign and self-limited. Among them are milia, cutis marmorata, congenital dermal melanocytosis, and the benign neonatal pustular eruptions (eg, benign cephalic pustulosis, erythema toxicum neonatorum, transient neonatal pustular melanosis). Clinicians need to recognize these benign skin conditions and differentiate them from more serious conditions, such as infectious pustular eruptions from bacterial, viral, and fungal causes, and inflammatory conditions, such as Langerhans cell histiocytosis...
February 2017: FP Essentials
https://www.readbyqxmd.com/read/28150339/retrospective-analysis-of-the-clinical-response-of-palmoplantar-pustulosis-after-dental-infection-control-and-dental-metal-removal
#4
Michiyoshi Kouno, Akihiro Nishiyama, Masaki Minabe, Naohiko Iguchi, Kenichiro Ukichi, Takeshi Nomura, Akira Katakura, Shinichi Takahashi
Both metal allergy and dental focal infection have been considered as causative factors for palmoplantar pustulosis, and several case reports described that the skin lesions were ameliorated after dental metal removal or dental infection control. However, limited data are available to evaluate the association of these factors with disease severity of palmoplantar pustulosis. This study is designed to analyze the clinical outcome of 85 palmoplantar pustulosis patients after dental infection control (n = 70), tonsillectomy (n = 6) and dental metal removal (n = 9)...
February 2, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28128085/antiphospholipid-syndrome-with-anti%C3%AE-2glicoprotein-1-antibodies-as-the-cause-of-recurrent-tibial-vein-thrombosis-in-sapho-syndrome
#5
Hanna Przepiera-Będzak, Marek Brzosko
The antiphospholipid antibody syndrome is defined by the presence of antiphospholipid antibodies in patients with recurrent venous or arterial thromboembolism (1). SAPHO syndrome is a rare disease, characterized by specific clinical manifestations of synovitis, acne pustulosis, hyperostosis, and osteitis. It is a disease that manifests with a combination of osseous and articular manifestations associated with skin lesions (2). Venous thrombosis complicating SAPHO syndrome seems to be uncommon with an unclear pathogenesis (3-9)...
December 2016: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/28122596/high-prevalence-of-autoimmune-disease-in-the-rare-inflammatory-bone-disorder-sternocostoclavicular-hyperostosis-survey-of-a-dutch-cohort
#6
Pieter A Valkema, Clare H Luymes, Janneke E Witteveen, Saskia le Cessie, Natasha M Appelman-Dijkstra, Pancras C W Hogendoorn, Neveen A T Hamdy
BACKGROUND: Sternocostoclavicular hyperostosis (SCCH; ORPHA178311) is a rare inflammatory disorder of the axial skeleton, the precise pathophysiology of which remains to be established. We addressed the potential association of SCCH with autoimmune processes by evaluating the lifetime prevalence of autoimmune disease in 70 patients with adult-onset SCCH and 518 SCCH-unaffected first-degree relatives (parents, siblings and children). Danish hospital registry data for autoimmune diseases were used as reference data...
January 25, 2017: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/28108048/bullous-pseudobullous-pustular-dermatoses
#7
Mark R Wick
Several dermatoses are typified by the formation of spaces (blisters; bullae) within or beneath the epidermis. These may be acellular or filled with particular species of inflammatory cells. Etiological categories include infectious, immune-mediated, genetic, drug-related, and idiopathic lesions. Examples of such disorders include impetigo, Herpes virus infections, pemphigus, bullous pemphigoid and pemphigoid gestationis, epidermolysis bullosa acquisita, IgA-related dermatoses, inherited epidermolysis bullosa variants, Hailey-Hailey disease, and porphyria cutanea tarda...
December 14, 2016: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/28107592/psoriasis-and-palmoplantar-pustulosis-an-endless-debate
#8
Alexandra Maria Giovanna Brunasso, Cesare Massone
Since 2007, palmoplantar pustulosis (PPP) has been classified as a separate entity and not a clinical variant of psoriasis despite the presence of certain phenotypes common in both diseases.(1) We read with interest the review by Misiak-Galazka et al., and we found that even after the extensive work (inclusion of 65 articles), some relevant data are missing.(1-3) The clue question remains the following: Is palmoplantar pustulosis (PPP) closely related to psoriasis or is PPP a separate condition? Herein we will systematically review the literature searching for frequency of psoriasis in PPP patients and we will discuss new genetic insights that connect PPP and psoriasis vulgaris...
January 20, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28107577/is-palmoplantar-pustulosis-simply-a-variant-of-psoriasis-or-a-distinct-entity
#9
Magdalena Misiak-Galazka, Hanna Wolska, Lidia Rudnicka
We read with interest the comment of Brunasso and Massone to our review article.(1) We agree that palmoplantar pustulosis (PPP) shares many features with palmoplantar pustular psoriasis (PPPP), and about 1/3 patients with PPP present with psoriasis lesions (skin, nail or joint changes). The close relationship and coexistence of PPP and psoriasis was confirmed in many studies. (3-5) This article is protected by copyright. All rights reserved.
January 20, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28099605/acute-localized-exanthematous-pustulosis-caused-by-cefoperazone-and-sodium-sulbactam
#10
Yan-Jing Qu, Shu-Bin Jin, Xiang-Chun Han, Li-Qiang Zheng
Acute localized exanthematous pustulosis is a localized variant of acute generalized exanthematous pustulosis, which is characterized by the eruption of multiple scattered pustules following drug administration. A 72-year-old woman presented with multiple erythematous pustules on her face, which had appeared two days after using cefoperazone and sodium sulbactam. Histopathological findings showed subcorneal pustules and mixed inflammatory cell infiltration in the dermis. The pustules resolved within about two weeks after the patient discontinued the antibiotics...
November 2016: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28072711/the-coexistence-of-sapho-syndrome-and-rheumatoid-arthritis-a-case-report
#11
Wenrui Xu, Chen Li, Weihong Zhang
RATIONAL: SAPHO (Synovitis-Acne-Pustulosis-Hyperstosis-Osteitis) syndrome is a rare disease featured by its dermatological and osteoarthritic disorders, the latter of which mainly affecting the anterior chest wall, spine, and sacroiliac joint. However, rheumatoid arthritis (RA) is a chronic autoimmune disease, mainly affecting the synovial tissue of small joints in hands and feet. Here, we present an extremely rare case diagnosed with both SAPHO syndrome and RA, with an onset interval of 10 years...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28060551/scleritis-associated-with-sapho-syndrome-a-case-report
#12
Rie Tanaka, Keiichi Sakurai, Toshikatsu Kaburaki
A 31-year-old woman developed bilateral painful red eyes. A slit-lamp examination revealed anterior diffuse scleritis. She had been diagnosed with palmoplantar pustulosis 2 years before. Further evaluation revealed hyperostosis of the sacroiliac joint and inflammation of the bilateral sternoclavicular joints and right sternocostal joint. Ultimately, she was diagnosed with SAPHO syndrome by rheumatologists after excluding other causative diseases. Scleritis associated with SAPHO syndrome is relatively uncommon...
January 6, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/28051238/acute-generalized-exanthematic-pustulosis-induced-by-spiramycin-usefulness-of-patch-testing
#13
Sarrah Kastalli, Ons Charfi, Sihem El Aïdli, Ahmed Zaïem, Riadh Daghfous
No abstract text is available yet for this article.
July 2016: La Tunisie Médicale
https://www.readbyqxmd.com/read/28040819/acute-localized-exanthematous-pustulosis-caused-by-flurbiprofen
#14
Nicola di Meo, Giuseppe Stinco, Pasquale Patrone, Sara Trevisini, Giusto Trevisan
No abstract text is available yet for this article.
November 2016: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/28000249/amicrobial-pustulosis-of-the-folds-report-of-4-cases
#15
Michael Z Wang, Michael J Camilleri, Ruifeng Guo, Carilyn N Wieland
Amicrobial pustulosis of the folds (APF) is a rare disease characterized by aseptic pustular lesions involving cutaneous folds, typically occurring in the context of an autoimmune disorder. We present 4 patients with APF, focusing on clinical and histopathologic characteristics to improve the recognition of this entity. All 4 patients had intertriginous and extra-intertriginous involvement. Common histopathologic features of skin biopsies in these patients were intracorneal, subcorneal, intraepidermal, perivascular, perifollicular and interstitial neutrophilic inflammation...
December 21, 2016: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/27993538/sapho-syndrome-in-childhood-a-case-report
#16
Manuel Vargas Pérez, Belén Sevilla Pérez
The acronym of SAPHO syndrome (synovitis, acne, pustulosis, hyperostosis and osteitis) combines a cluster of cutaneous and musculoskeletal manifestations, such as hyperostosis of bones of the anterior chest wall associated with acne fulminans and hidradenitis suppurativa. There are no validated diagnostic criteria in children. Nonsteroidal anti-inflammatory drugs are not always sufficient, and the use of corticosteroids, disease-modifying agents, tumor necrosis factor-α inhibitors or bisphosphonates may be necessary...
December 16, 2016: Reumatología Clinica
https://www.readbyqxmd.com/read/27979020/antiepilepsy-drugs-and-the-immune-system
#17
REVIEW
Neetu Godhwani, Sami L Bahna
OBJECTIVE: To alert physicians about the peculiar adverse effects of antiepilepsy drugs (AEDs) on the immune system. DATA SOURCES: PubMed literature during the past 25 years. STUDY SELECTIONS: Reports and review articles on the hypersensitivities of AEDs and their effect on immunity. RESULTS: AEDs have significant effects on the immune system in the form of hypersensitivity or immune suppression. IgE-mediated reactions can be urticaria, angioedema, bronchospasm, or anaphylaxis...
December 2016: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/27966434/clindamycin-induced-acute-generalised-exanthematous-pustulosis-five-cases-and-a-review-of-the-literature
#18
T J L Smeets, N Jessurun, L Härmark, S H Kardaun
Acute generalised exanthematous pustulosis (AGEP) is a rare but serious cutaneous adverse drug reaction, often related to antibiotics such as beta-lactams or macrolides. However, it is rarely associated with clindamycin which belongs to the lincosamide antibiotics. The Netherlands Pharmacovigilance Centre Lareb received five reports of AGEP associated with the use of clindamycin. We present these five cases and provide support for this association from the Lareb database, the database of the WHO Collaborating Centre for International Drug Monitoring (Vigibase™), the database of the European Medicine Agency (Eudravigilance), and from a mini review of the literature...
December 2016: Netherlands Journal of Medicine
https://www.readbyqxmd.com/read/27936930/different-contributions-of-cdkal1-kif21b-and-lrrk2-muc19-polymorphisms-to-sapho-syndrome-rheumatoid-arthritis-ankylosing-spondylitis-and-seronegative-spondyloarthropathy
#19
Nan Li, Junfen Ma, Kai Li, Changlong Guo, Liang Ming
OBJECTIVES: Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome, rheumatoid arthritis (RA), ankylosing spondylitis (AS), and seronegative spondyloarthropathy (SPA) are autoimmune diseases of unknown etiology, which share some clinical manifestations in common. Previous family-based investigations support genetic contributions to the susceptibility of these diseases. The current study evaluated whether three previously reported AS-associated single-nucleotide polymorphisms (SNPs), rs6908425 T>C in CDKAL1, rs11584383 T>C near KIF21B, and rs11175593 C>T near LRRK2/MUC19, have any genetic overlap across multiple autoimmune diseases including SAPHO syndrome, RA, AS, and SPA...
February 2017: Genetic Testing and Molecular Biomarkers
https://www.readbyqxmd.com/read/27925156/case-report-of-multiple-pustules-of-the-bilateral-lower-limbs-caused-by-a-granulocyte-colony-stimulating-factor-producing-solid-pseudopapillary-tumour-of-the-pancreas
#20
Y Iwata, T Kobayashi, M Kuroda, Y Mizoguchi, M Arima, S Numata, S Watanabe, A Yagami, K Matsunaga, K Sugiura
Here we report the first case of neutrophilic dermatoses related to a granulocyte colony-stimulating factor (GCSF)-producing solid pseudopapillary tumour (SPT). The patient was a 39-year-old woman presenting with scattered pustules and crusts of the palms/heels/thighs and plaques of the bilateral lower legs. The skin biopsy revealed dense neutrophil infiltration in the epidermis to the corium. A pancreatic head tumour was detected on computed tomography. A pathological examination of the resected specimen suggested a SPT...
December 7, 2016: British Journal of Dermatology
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