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Todd R Kramer
This case report examines a vesiculopustular reaction which occurred in a young Marine 9 d after receiving the smallpox vaccination. Review of the CDC guidelines, ACAM2000 package insert, and literature surrounding the smallpox vaccine reveals several well-established adverse cutaneous reactions associated with vaccination. These dermatologic reactions are typically mild and self-limited, but do have the potential to be life threatening - especially in those with immunocompromise. Unfortunately, the correct diagnosis can often be difficult to make, as many of these rashes share similar characteristics...
March 13, 2018: Military Medicine
Reyhan Kose, Taskin Senturk, Gokhan Sargin, Songul Cildag, Yasemin Kara
Pustulotic arthro-osteitis (PAO) is a rare chronic inflammatory disease, which has now been classified as a seronegative spondyloarthritis. The sternoclavicular and sternocostal joints, pelvis, vertebra, hip, and long bones are affected. Skin findings of the disease are accepted as a variant of pustular psoriasis, but some authors have suggested that palmoplantar pustulosis (PPP) is a different entity. The synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome should be considered in the differential diagnosis...
February 2018: Eurasian Journal of Medicine
Abhishek De, Sudip Das, Aarti Sarda, Dayamay Pal, Projna Biswas
Acute generalised exanthematous pustulosis (AGEP) is a severe cutaneous adverse reaction and is attributed to drugs in more than 90% of cases. It is a rare disease, with an estimated incidence of 1-5 patients per million per year. The clinical manifestations characterised by the rapid development of sterile pustular lesions, fever and leucocytosis. Number of drugs has been reported to be associated with AGEP, most common being the antibiotics. Histopathologically there is intraepidermal pustules and papillary dermal oedema with neutrophilic and eosinophilic infiltrations...
January 2018: Indian Journal of Dermatology
Mindy M Sampson, Olga Klinkova, Julie Vitko, Beata Casanas
No abstract text is available yet for this article.
February 6, 2018: American Journal of Medicine
Masashi Akiyama, Takuya Takeichi, John A McGrath, Kazumitsu Sugiura
Classifying inflammatory skin diseases is challenging, especially for the expanding group of disorders triggered by genetic factors resulting in hyperactivated innate immunity that result in overlapping patterns of dermal and epidermal inflammation with hyperkeratosis. For such conditions, the umbrella term "autoinflammatory keratinization diseases" (AIKD) has been proposed. AIKD encompasses diseases with mixed pathomechanisms of autoinflammation and autoimmunity, and includes IL-36 receptor antagonist (IL-36Ra)-related pustulosis, CARD14-mediated pustular psoriasis, pityriasis rubra pilaris (PRP) type V, and familial keratosis lichenoides chronica (KLC)...
February 1, 2018: Journal of Dermatological Science
Abhishek Thakur, Anuradha Bishnoi, Sunil Dogra, Tarun Narang
BACKGROUND: Very few studies have assessed the efficacy of excimer treatment in palmoplantar psoriasis (PPP), and none has compared the excimer with calcipotriol-clobetasol combination. PURPOSE: To compare the effectiveness and safety of excimer lamp versus topical ointment containing calcipotriol (0.005% w/w) and clobetasol propionate (0.05% w/w) combination in PPP. METHODS: This right-left randomization trial included 36 patients with PPP, who received treatment with excimer lamp (twice weekly) on one side and calcipotriol-clobetasol combination once daily on another side for 12 weeks, followed by 8 weeks follow-up...
February 8, 2018: Photodermatology, Photoimmunology & Photomedicine
Tadashi Terui, Satomi Kobayashi, Yukari Okubo, Masamoto Murakami, Keiichiro Hirose, Hiroshi Kubo
Importance: Palmoplantar pustulosis (PPP) is a recalcitrant skin disease with no biologics currently approved for treatment. The involvement of interleukin 23 (IL-23) and cytokines of the type 17 helper T cell lineage in the pathogenesis of PPP has been recently postulated. Objective: To evaluate the efficacy and safety of guselkumab, an anti-IL-23 monoclonal antibody, in Japanese patients with PPP. Design, Setting, and Participants: This double-blind, randomized, placebo-controlled, parallel-group, 24-week trial was conducted between May 14, 2013, and September 27, 2014, at 11 centers in Japan...
February 7, 2018: JAMA Dermatology
Yuki Yamazaki, Risa Watanabe, Takahiro Ishikawa, Takichi Munetsugu, Aya Nishizawa, Takahiro Satoh
No abstract text is available yet for this article.
February 1, 2018: European Journal of Dermatology: EJD
Oscar M Moreno-Arrones, Rosario Carrillo-Gijon, Elena Sendagorta, Luis Rios-Buceta
No abstract text is available yet for this article.
March 2018: JAAD Case Reports
Hyun Yi Suh, Jooyoon Bae, Hong Lim Kim, Kyung Ho Kim, Ran-Hui Cha, Ji Young Ahn, Jai Il Youn, Mi Youn Park
No abstract text is available yet for this article.
February 2018: Annals of Dermatology
Chen Li, Xiaochuan Sun, Yihan Cao, Wenrui Xu, Wen Zhang, Zhenhua Dong
RATIONALE: SAPHO (synovitis, acne, pustulosis, hyperostosis, and osteitis) syndrome is an autoinflammatory disease with no standardized treatment. Tripterygium wilfordii hook f (TwHF) is a Chinese herb with immunosuppressive effects and has been used to treat some chronic inflammatory diseases. However, it has not been reported as a therapeutic option in SAPHO syndrome. Here we present the first report in which a remarkable remission of SAPHO syndrome was achieved in response to TwHF...
November 2017: Medicine (Baltimore)
M Teresa Bordel Gómez, Cristina Martín García, Carmen Meseguer Yebra, M Isabel Zafra Cobo, M Esther Cardeñoso Álvarez, Juan Sánchez Estella
No abstract text is available yet for this article.
February 2018: Contact Dermatitis
Stéphanie Olivier, Laurence De Montjoye, Isabelle Tromme, Marie Baeck
No abstract text is available yet for this article.
January 16, 2018: European Journal of Dermatology: EJD
Chetan Sharma, Brian Chow
Synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) syndrome is considered after exclusion of infection and arthritis; however, microbial infection may be present in osteoarticular lesions of these patients. Chronic osteomyelitis and associated bacterial infection were detected in a recurrent osteoarticular lesion in an adolescent patient with a history of clavicle pain, who complained of recurrent swelling in the left clavicle. Most pediatric case reports of SAPHO syndrome describe patients with associated skin conditions...
June 2017: WMJ: Official Publication of the State Medical Society of Wisconsin
Meltem Akçaboy, Sevcan Azime Bakkaloğlu-Ezgü, Bahar Büyükkaragöz, Emel Isıyel, Yasar Kandur, Enver Hasanoğlu, Necla Buyan
Akçaboy M, Bakkaloğlu-Ezgü SA, Büyükkaragöz B, Isıyel E, Kandur Y, Hasanoğlu E, Buyan N. Successful treatment of a childhood synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome with subcutaneous methotrexate: A case report. Turk J Pediatr 2017; 59: 184-188. SAPHO syndrome (synovitis, acne, pustulosis, hyperostosis and osteitis) is defined as a syndrome that is related to various osteoarticular manifestations and chronic dermatological conditions especially severe acne. SAPHO syndrome is a rare and unusual clinical entity in childhood and treatment choices are variable...
2017: Turkish Journal of Pediatrics
Allison Rosen, Joseph C Del Paggio, Barry Chan, Suzan Abu-Abed, Matthew Rawls, Anne K Ellis
No abstract text is available yet for this article.
January 2018: Annals of Allergy, Asthma & Immunology
Mari Orime
Diagnosis of severe cutaneous adverse drug reactions should involve immunohistopathological examination, which gives insight into the pathomechanisms of these disorders. The characteristic histological findings of erythema multiforme (EM), Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) provide conclusive evidence demonstrating that SJS/TEN can be distinguished from EM. Established SJS/TEN shows full-thickness, extensive keratinocyte necrosis that develops into subepidermal bullae. Drug-induced hypersensitivity syndrome (DIHS) and exanthema in drug reaction with eosinophilia and systemic symptoms (DRESS) each display a variety of histopathological findings, which may partly correlate with the clinical manifestations...
2017: Journal of Immunology Research
A B Weins, K Scharffetter-Kochanek, T Weiss, K Brockow, T Biedermann, C Psotta-Schachtner, M Mockenhaupt, J M Weiss
No abstract text is available yet for this article.
December 10, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
S Hegazy, M P Konstantinou, C Bulai Livideanu, M Tauber, C Uthurriague, C Paul
No abstract text is available yet for this article.
December 1, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
Grace L Lee, Amy Y-Y Chen
Neutrophilic dermatoses are a group of inflammatory skin disorders characterized by an overactive innate immune system with dysregulation of neutrophils without underlying infectious etiology. The major representative conditions discussed are Sweet syndrome; pyoderma gangrenosum; neutrophilic eccrine hidradenitis; palmoplantar eccrine hidradenitis; subcorneal pustular dermatoses; bowel-associated dermatosis arthritis syndrome; and synovitis, acne, pustulosis, hyperostosis, and osteitis. We will also discuss other neutrophilic conditions present almost exclusively in the pediatric population, including congenital erosive and vesicular dermatosis with reticulated supple scarring and the recently described group of autoinflammatory diseases...
November 2017: Clinics in Dermatology
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