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Anti carbonic anhydrase II antibody

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https://www.readbyqxmd.com/read/27234558/antibodies-reacting-to-carbonic-anhydrase-isozymes-i-and-ii-and-albumin-in-sera-from-dogs
#1
Toshiho Nishita, Rui Miyazaki, Takae Miyazaki, Hideharu Ochiai, Kensuke Orito
IgGs to carbonic anhydrase isozymes (CA-I and CA-II) and albumin were identified in dog serum. IgG titers were determined in the sera of asymptomatic dogs, and in dogs with atopic dermatitis, diarrhea and/or vomiting, diabetes and/or pancreatitis, kidney disease, hepatic disease, and thyroid gland disease, using ELISA. Low titres of IgG-reactive CA-I, CA-II, BSA, and CSA were found in the sera of healthy beagles. Compared with healthy beagles, there was a significant difference in the titers of antibodies against CA-I in asymptomatic dogs, dogs with diabetes and/or pancreatitis, or thyroid gland disease, or hepatic disease...
June 2016: Research in Veterinary Science
https://www.readbyqxmd.com/read/27185162/unique-epitopes-for-carbonic-anhydrase-ii-autoantibodies-related-to-autoimmune-retinopathy-and-cancer-associated-retinopathy
#2
Grazyna Adamus, Sufang Yang, Richard G Weleber
High titers of anti-carbonic anhydrase II (anti-CA II) autoantibodies were detected in sera of patients with autoimmune retinopathies (AR), including cancer-associated retinopathy (CAR) and also in normal population. The goal was to investigate whether unique immunodominant epitopes for anti-CAII autoantibodies occur in AR and CAR. A cohort of 216 patients with symptoms of AR and CAR and healthy controls, seropositive for anti-CA II autoantibodies were analyzed for the prevalence of CAII major domains. Autoantibody titers against CAII in sera were determined by ELISA...
June 2016: Experimental Eye Research
https://www.readbyqxmd.com/read/26869529/screening-for-mog-igg-and-27-other-anti-glial-and-anti-neuronal-autoantibodies-in-pattern-ii-multiple-sclerosis-and-brain-biopsy-findings-in-a-mog-igg-positive-case
#3
Sven Jarius, Imke Metz, Fatima Barbara König, Klemens Ruprecht, Markus Reindl, Friedemann Paul, Wolfgang Brück, Brigitte Wildemann
BACKGROUND: Histopathological studies have revealed four different immunopathological patterns of lesion pathology in early multiple sclerosis (MS). Pattern II MS is characterised by immunoglobulin and complement deposition in addition to T-cell and macrophage infiltration and is more likely to respond to plasma exchange therapy, suggesting a contribution of autoantibodies. OBJECTIVE: To assess the frequency of anti-myelin oligodendrocyte glycoprotein (MOG), anti-M1-aquaporin-4 (AQP4), anti-M23-AQP4, anti-N-methyl-d-aspartate-type glutamate receptors (NMDAR) and 25 other anti-neural antibodies in pattern II MS...
February 11, 2016: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/26137589/mitochondrial-dependent-autoimmunity-in-membranous-nephropathy-of-igg4-related-disease
#4
Simona Buelli, Luca Perico, Miriam Galbusera, Mauro Abbate, Marina Morigi, Rubina Novelli, Elena Gagliardini, Chiara Tentori, Daniela Rottoli, Ettore Sabadini, Takao Saito, Mitsuhiro Kawano, Takako Saeki, Carlamaria Zoja, Giuseppe Remuzzi, Ariela Benigni
The pathophysiology of glomerular lesions of membranous nephropathy (MN), including seldom-reported IgG4-related disease, is still elusive. Unlike in idiopathic MN where IgG4 prevails, in this patient IgG3 was predominant in glomerular deposits in the absence of circulating anti-phospholipase A2 receptor antibodies, suggesting a distinct pathologic process. Here we documented that IgG4 retrieved from the serum of our propositus reacted against carbonic anhydrase II (CAII) at the podocyte surface. In patient's biopsy, glomerular CAII staining increased and co-localized with subepithelial IgG4 deposits along the capillary walls...
May 2015: EBioMedicine
https://www.readbyqxmd.com/read/25283602/anti-carbonic-anhydrase-antibodies-in-iron-deficiency-anemia
#5
Ahmet Menteşe, Nergiz Erkut, Ayşegül Sümer, Diler Us Altay, Ahmet Alver, Mehmet Sönmez
OBJECTIVES: Studies on experimental animals have shown that elevated oxidative stress in erythrocytes leads to the formation of autoantibodies against carbonic anhydrase (CA) and anemia. This study investigated the presence of CA I and II autoantibodies in patients with iron deficiency anemia (IDA). METHODS: Forty patients with IDA and 40 healthy controls were included in the study. Serum CA I and II autoantibody levels were analyzed using enzyme-linked immunosorbent assay...
July 2015: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/25194335/utility-of-serum-igg-igg4-and-carbonic-anhydrase-ii-antibodies-in-distinguishing-autoimmune-pancreatitis-from-pancreatic-cancer-and-chronic-pancreatitis
#6
Renata Talar-Wojnarowska, Anita Gąsiorowska, Marek Olakowski, Daria Dranka-Bojarowska, Paweł Lampe, Jacek Śmigielski, Magdalena Kujawiak, Janina Grzegorczyk, Ewa Małecka-Panas
PURPOSE: Autoimmune pancreatitis (AIP) can mimic pancreatic cancer in its clinical presentation, imaging features and laboratory parameters. The aim of our study was to compare IgG, IgG4 and anti-CAIIAb serum levels in patients with AIP, pancreatic adenocarcinoma (PA) and chronic pancreatitis (CP) and to assess their clinical significance and utility in differential diagnosis of pancreatic diseases. PATIENT/METHODS: The study included 124 patients: 45 with PA, 24 with AIP and 55 with CP...
September 2014: Advances in Medical Sciences
https://www.readbyqxmd.com/read/24903210/anti-carbonic-anhydrase-ii-antibodies-in-end-stage-renal-disease-patients
#7
Ahmet Alver, Ahmet Menteşe, Ümit Menteşe, Ayşegül Sümer, Fahri Uçar, Diler Us Altay
OBJECTIVE: The aim of this study was to investigate the presence of anti-carbonic anhydrase (CA II) autoantibodies in patients with end-stage renal disease (ESRD) and relationships between the autoantibody titers and ghrelin, glucose, blood urea nitrogen (BUN) and creatinine. SUBJECTS AND METHODS: Serum CA II autoantibody titers, malondialdehyde (MDA), BUN, creatinine and ghrelin levels were measured in 45 ESRD patients and 45 healthy subjects. RESULTS: The CA II autoantibody titers in the ESRD group (0...
2014: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/24672741/significance-of-anti-retinal-autoantibodies-in-cancer-associated-retinopathy-with-gynecological-cancers
#8
Grazyna Adamus, Dongseak Choi, Anitha Raghunath, Jade Schiffman
BACKGROUND: The presence of autoantibodies (AAbs) is the primary serological indicator of autoimmunity. Cancer-associated retinopathy (CAR) is associated with AAbs and different types of cancer. The goal of the study was to examine the profile of serum autoantibodies in women with gynecological cancers with and without paraneoplastic visual manifestation. METHODS: Retrospective studies of a cohort of 46 women with symptoms of CAR and gynecological tumors, including endometrial, cervical, ovarian, and fallopian tubes, 111 women with similar tumors without symptoms of CAR, and 60 age-matched healthy controls...
December 1, 2013: Journal of Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/24650962/identification-of-commensal-flora-associated-antigen-as-a-pathogenetic-factor-of-autoimmune-pancreatitis
#9
Naoko Yanagisawa, Ikuko Haruta, Kyoko Shimizu, Toru Furukawa, Tomoaki Higuchi, Noriyuki Shibata, Keiko Shiratori, Junji Yagi
OBJECTIVES: Autoimmune pancreatitis (AIP) is a chronic fibro-inflammatory disease of the pancreas constituting, in part, a recently defined nosological entity of IgG4-related systemic sclerosing diseases. The pathogenetic factors of AIP have not been fully elucidated. We previously established a mouse model of AIP using chronic exposure to a commensal bacteria, Escherichia coli. METHODS: To determine the pathogenetically relevant antigen of E. coli, the outer membrane fractions of E...
March 2014: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/24428923/a-case-of-paraneoplastic-optic-neuropathy-and-outer-retinitis-positive-for-autoantibodies-against-collapsin-response-mediator-protein-5-recoverin-and-%C3%AE-enolase
#10
Michiyuki Saito, Wataru Saito, Atsuhiro Kanda, Hiroshi Ohguro, Susumu Ishida
BACKGROUND: Specific cross-reacting autoimmunity against recoverin or collapsin response mediator protein (CRMP)-5 is known to cause cancer-associated retinopathy or paraneoplastic optic neuropathy, respectively. We report a rare case with small cell lung carcinoma developing bilateral neuroretinitis and unilateral focal outer retinitis positive for these antibodies. CASE PRESENTATION: A 67-year-old man developed bilateral neuroretinitis and foveal exudation in the right eye...
2014: BMC Ophthalmology
https://www.readbyqxmd.com/read/24126040/autoimmune-retinopathy-associated-with-carcinoid-tumour-of-the-small-bowel
#11
Siddharth Ogra, Dianne Sharp, Helen Danesh-Meyer
Cancer associated retinopathy (CAR) is an immune mediated paraneoplastic condition associated with vision loss. It has been associated with a variety of systemic malignancies. The primary clinical presentation is rapid, progressive vision loss. Rod and cone dysfunction can cause other associated symptoms, such as nyctalopia. Electrophysiological testing and detection of anti-retinal antibodies are used to confirm the diagnosis. To our knowledge we describe the first patient with CAR associated with a carcinoid tumour of the gastrointestinal system...
February 2014: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/24063704/serum-anti-carbonic-anhydrase-antibodies-and-oxidant-antioxidant-balance-in-patients-with-acute-anterior-uveitis
#12
COMPARATIVE STUDY
Adem Turk, Murat Aykut, Nurettin Akyol, Mehmet Kola, Ahmet Mentese, Aysegul Sumer, Ahmet Alver, Hidayet Erdol
PURPOSE: To study the existence of anti-carbonic anhydrase antibodies (anti-CA-I&II) in acute anterior uveitis (AAU) patients and to analyze the relationship between the levels of these antibodies and the total antioxidant capacity (TAC), total oxidant capacity (TOC), oxidative stress index (OSI), and malondialdehyde (MDA) level. METHODS: Forty-five AAU cases and 43 healthy controls were enrolled in this prospective study. RESULTS: The average anti-CA I and II antibody levels were 0...
April 2014: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/23846285/malondialdehyde-and-ca-ii-autoantibody-levels-are-elevated-in-children-with-undescended-testes
#13
Ahmet Alver, Mustafa İmamoğlu, Ahmet Menteşe, Ayşe Şentürk, Serap Samut Bülbül, Cemil Kahraman, Ayşegül Sümer
PURPOSE: In the pathogenesis of sub-fertility/infertility and testicular cancer related to undescended testes, oxidative stress, inflammation and autoimmunity are important factors. Therefore, the present study was designed to determine serum oxidative stress markers and carbonic anhydrase (CA) II autoantibodies in boys with undescended testes (UDT), and to investigate the relationship between these parameters. METHODS: Serum CA II autoantibody titers, malondialdehyde (MDA), ischemia modified albumin (IMA), protein carbonyl content and soluble CD40 ligand (sCD40L) levels were measured in 59 boys with UDT and 30 healthy subjects...
February 2014: World Journal of Urology
https://www.readbyqxmd.com/read/23709596/inhibition-of-carbonic-anhydrase-prevents-the-na-h-exchanger-1-dependent-slow-force-response-to-rat-myocardial-stretch
#14
Lorena A Vargas, Romina G Díaz, Erik R Swenson, Néstor G Pérez, Bernardo V Álvarez
Myocardial stretch is an established signal that leads to hypertrophy. Myocardial stretch induces a first immediate force increase followed by a slow force response (SFR), which is a consequence of an increased Ca(2+) transient that follows the NHE1 Na(+)/H(+) exchanger activation. Carbonic anhydrase II (CAII) binds to the extreme COOH terminus of NHE1 and regulates its transport activity. We aimed to test the role of CAII bound to NHE1 in the SFR. The SFR and changes in intracellular pH (pHi) were evaluated in rat papillary muscle bathed with CO2/HCO3(-) buffer and stretched from 92% to 98% of the muscle maximal force development length for 10 min in the presence of the CA inhibitor 6-ethoxzolamide (ETZ, 100 μM)...
July 15, 2013: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/21427176/novel-carbonic-anhydrase-autoantibodies-and-renal-manifestations-in-patients-with-primary-sjogren-s-syndrome
#15
Marja Pertovaara, Fatemeh Bootorabi, Marianne Kuuslahti, Amos Pasternack, Seppo Parkkila
OBJECTIVE: Anti-carbonic anhydrase II (anti-CA II) antibodies have been related to renal manifestations of primary SS (pSS), and animal studies have even suggested a pathogenic role for them. However, not all pSS patients with renal tubular acidosis (RTA) present with anti-CA II antibodies. Recently, several novel CA isoenzymes have been recognized and we aimed to investigate whether antibodies to these are associated with renal manifestations of pSS. METHODS: We examined anti-CA II antibodies as well as anti-CA I, VI, VII and XIII antibodies by ELISA tests in 74 pSS patients on whom detailed nephrological examinations had been performed and, as controls, in 56 subjects with sicca symptoms, but no pSS...
August 2011: Rheumatology
https://www.readbyqxmd.com/read/21339605/mechanistic-insight-into-gramicidin-based-detection-of-protein-ligand-interactions-via-sensitized-photoinactivation
#16
Tatyana I Rokitskaya, Michael X Macrae, Steven Blake, Natalya S Egorova, Elena A Kotova, Jerry Yang, Yuri N Antonenko
Among the many challenges for the development of ion channel-based sensors is the poor understanding of how to engineer modified transmembrane pores with tailored functionality that can respond to external stimuli. Here, we use the method of sensitized photoinactivation of gramicidin A (gA) channels in planar bilayer lipid membranes to help elucidate the underlying mechanistic details for changes in macroscopic transmembrane ionic current observed upon interaction of C-terminally attached gA ligands with specific proteins in solution...
November 17, 2010: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/21244564/serum-anti-carbonic-anhydrase-ii-antibodies-and-oxidant-antioxidant-balance-in-pre-eclampsia
#17
Rezzan Aliyazicioglu, Suleyman Guven, Ahmet Mentese, Sevgi Kolayli, Sevil Cengiz, Orhan Deger, Ahmet Alver
PROBLEM  The aim of this study was to investigate the presence of anti-carbonic anhydrase II antibodies (anti-CA II) antibodies in pre-eclampsia and the relationships between the autoantibodies, total antioxidant capacity (TAC) and total oxidant capacity (TOC), malondialdehyde (MDA) and oxidative stres index (OSI) parameters. METHOD OF STUDY  We studied 40 early and late onset pre-eclamptic patients and 40 healthy pregnant control and 39 healthy non-pregnant control subjects. Serum CA II antibodies, TAC and TOC, and MDA parameters were studied by ELISA...
October 2011: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/20942168/-anti-carbonic-anhydrase-ii-antibody
#18
Hideo Hosoda, Masako Okawa-Takatsuji, Wahei Shinmura, Naoaki Hashimoto, Yusei Ikeda
No abstract text is available yet for this article.
June 2010: Nihon Rinsho. Japanese Journal of Clinical Medicine
https://www.readbyqxmd.com/read/20045496/studies-on-glyphosate-induced-carcinogenicity-in-mouse-skin-a-proteomic-approach
#19
Jasmine George, Sahdeo Prasad, Zafar Mahmood, Yogeshwer Shukla
Glyphosate is a widely used broad spectrum herbicide, reported to induce various toxic effects in non-target species, but its carcinogenic potential is still unknown. Here we showed the carcinogenic effects of glyphosate using 2-stage mouse skin carcinogenesis model and proteomic analysis. Carcinogenicity study revealed that glyphosate has tumor promoting activity. Proteomic analysis using 2-dimensional gel electrophoresis and mass spectrometry showed that 22 spots were differentially expressed (>2 fold) on glyphosate, 7, 12-dimethylbenz[a]anthracene (DMBA) and 12-O-tetradecanoyl-phorbol-13-acetate (TPA) application over untreated control...
March 10, 2010: Journal of Proteomics
https://www.readbyqxmd.com/read/20031029/serum-anti-carbonic-anhydrase-i-and-ii-antibodies-and-idiopathic-recurrent-pregnancy-loss
#20
S Caner Karahan, Suleyman Guven, Ahmet Mentese, Aynur Bacak, Muge Kopuz, Mehmet Ozeren
In up to 50% of recurrent pregnancy losses (RPL), the underlying pathophysiological mechanisms remain undetermined. Immunological factors may be involved. The objective of this study was to compare serum concentrations of autoantibodies to carbonic anhydrase (CA) I and II in women with and without RPL. Serum anti-CA-I and anti-CA-II concentrations in 29 women with RPL and 39 women without RPL on menstrual cycle day 3 were assessed and compared for this prospective age-matched controlled study. The mean serum anti-CA-I (0...
December 2009: Reproductive Biomedicine Online
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