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Doxorubicin il-10

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https://www.readbyqxmd.com/read/27897404/doxorubicin-inhibits-muscle-inflammation-after-eccentric-exercise
#1
Sheng-Chih Huang, Jin-Fu Wu, Suchada Saovieng, Wei-Horng Chien, Ming-Fen Hsu, Xiao-Fei Li, Shin-Da Lee, Chih-Yang Huang, Chih-Yang Huang, Chia-Hua Kuo
BACKGROUND: Doxorubicin, a widely used anti-tumour drug, is known to cause muscle loss in cancer patients. METHODS: Following an acute dose of doxorubicin injection (2.5 mg/kg per body weight), we examined macrophage distribution in rat soleus muscle challenged by eccentric exercise (downhill running). Long-term doxorubicin treatment (one injection every 3 days) on muscle mass and survival were also determined. RESULTS: Under non-exercised condition, increased tumour necrosis factor (TNF)-alpha mRNA and decreased IL-10 mRNA were observed in soleus muscle of doxorubicin-treated rats, compared with saline-treated control rats...
October 10, 2016: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/27738441/efficacy-of-compound-kushen-injection-in-combination-with-induction-chemotherapy-for-treating-adult-patients-newly-diagnosed-with-acute-leukemia
#2
Honglei Tu, Bo Lei, Shan Meng, Hailing Liu, Yongchang Wei, Aili He, Wanggang Zhang, Fuling Zhou
We assessed the clinical effectiveness and safety of CKI (compound Kushen injection) plus standard induction chemotherapy for treating adult acute leukemia (AL). We randomly assigned 332 patients with newly diagnosed AL to control (n = 165, receiving DA (daunorubicin and cytarabine) or hyper-CVAD (fractionated cyclophosphamide, doxorubicin, vincristine, and dexamethasone)) or treatment (n = 167, receiving CKI and DA or hyper-CVAD) groups. Posttreatment, treatment group CD3+, CD4+, CD4+/CD8+, natural killer (NK) cell, and immunoglobulin (IgG, IgA, and IgM) levels were significantly higher than those of the control group (p < 0...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27713132/highly-elevated-serum-lactate-dehydrogenase-is-associated-with-central-nervous-system-relapse-in-patients-with-diffuse-large-b-cell-lymphoma-results-of-a-multicenter-prospective-cohort-study
#3
Seok Jin Kim, Jun Sik Hong, Myung Hee Chang, Jeong-A Kim, Jae-Yong Kwak, Jin Seok Kim, Dok Hyun Yoon, Won Sik Lee, Young Rok Do, Hye Jin Kang, Hyeon-Seok Eom, Yong Park, Jong-Ho Won, Yeung-Chul Mun, Hyo Jung Kim, Jung Hye Kwon, Jee Hyun Kong, Sung Yong Oh, Sunah Lee, Sung Hwa Bae, Deok-Hwan Yang, Hyun Jung Jun, Yang Soo Kim, Hwan Jung Yun, Soon Il Lee, Min Kyoung Kim, Eun Kyung Park, Won Seog Kim, Cheolwon Suh
Central nervous system involvement remains a challenging issue in the treatment of patients with diffuse large B-cell lymphoma. We conducted a prospective cohort study with newly diagnosed diffuse large B-cell lymphoma patients receiving rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone to identify incidence and risk factors for central nervous system involvement. Among 595 patients, 279 patients received pre-treatment central nervous system evaluation, and 14 patients had central nervous system involvement at diagnosis (2...
October 4, 2016: Oncotarget
https://www.readbyqxmd.com/read/27706571/effects-of-shenkangling-intervention-on-the-mapk-pathway-in-rats-with-doxorubicin-induced-nephropathy
#4
S Ai, Y Y Lin, J Zheng, C X Qiu, Y J Liu, X Lin
Shenkangling plays a role of Yishenhuoxue effect for the treatment of children with nephrotic syndrome. The aim of this study was to investigate the effects of Shenkangling intervention on the mitogen-activated protein kinase (MAPK) pathway in rats with Adriamycin-induced nephropathy (AN) and its underlying mechanism of action. Nephrosis was induced in healthy Sprague-Dawley rats by doxorubicin and the rats were untreated or treated with prednisone, simvastatin, Shenkangling, or a combination thereof. Using real-time PCR, the mRNA expression levels of Chemokine (C-X-C motif) ligand 16 (CXCL16), A Disintegrin and metalloproteinase domain-containing protein 10 (ADAM10), and ADAM17 in the renal tissues of these rats were found to be decreased by the various treatments compared to those in the untreated doxorubicin-induced nephrosis rats...
August 19, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27465663/the-cardioprotective-effect-of-melatonin-and-exendin-4-treatment-in-a-rat-model-of-cardiorenal-syndrome
#5
Sarah Chua, Fan-Yen Lee, Hsin-Ju Chiang, Kuan-Hung Chen, Hung-I Lu, Yen-Ta Chen, Chih-Chao Yang, Kun-Chen Lin, Yi-Ling Chen, Gour-Shenq Kao, Chih-Hung Chen, Hsueh-Wen Chang, Hon-Kan Yip
We investigated the cardioprotective effect of melatonin (Mel) and exendin-4 (Ex4) treatment in a rat model of cardiorenal syndrome (CRS). Male-adult SD rats (n=48) were randomly and equally divided into sham-control (SC), dilated cardiomyopathy (DCM) (doxorubicin 7 mg/kg i.p. every five days/ 4 doses), CRS (defined as DCM + CKD) only, CRS-Mel (20 mg/kg/day), CRS-Ex4 (10 μg/kg/day) and CRS-Mel-Ex4. In-vitro results showed protein expressions of oxidative-stress (NOX-1/NOX-2/oxidized protein), DNA/mitochondrial-damaged (γ-H2AX/cytosolic cytochrome-C) and apoptotic (cleaved caspase-3/PARP) biomarkers, and senescence (β-galactosidase cells) were upregulated, whereas mitochondrial ATP level was decreased in doxorubicin/ p-Cresol-treated H9C2 cells that were revised by Mel and Ex4 treatments (all p<0...
July 28, 2016: Journal of Pineal Research
https://www.readbyqxmd.com/read/27347634/keloids-and-hypertrophic-scars-pathophysiology-classification-and-treatment
#6
Brian Berman, Andrea Maderal, Brian Raphael
BACKGROUND: Keloid and hypertrophic scars represent an aberrant response to the wound healing process. These scars are characterized by dysregulated growth with excessive collagen formation, and can be cosmetically and functionally disruptive to patients. OBJECTIVE: Objectives are to describe the pathophysiology of keloid and hypertrophic scar, and to compare differences with the normal wound healing process. The classification of keloids and hypertrophic scars are then discussed...
June 24, 2016: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/27345402/exosomes-mir-126a-released-from-mdsc-induced-by-dox-treatment-promotes-lung-metastasis
#7
Z Deng, Y Rong, Y Teng, X Zhuang, A Samykutty, J Mu, L Zhang, P Cao, J Yan, D Miller, H-G Zhang
Acquired resistance to chemotherapy remains a major stumbling block in cancer treatment. Chronic inflammation has a crucial role in induction of chemoresistance and results, in part, from the induction and expansion of inflammatory cells that include myeloid-derived suppressor cells (MDSCs) and IL-13(+) Th2 cells. The mechanisms that lead to induction of activated MDSCs and IL-13(+) Th2 cells have not yet been identified. Here we demonstrated that doxorubicin (DOX) treatment of 4T1 breast tumor-bearing mice led to the induction of IL-13R(+)miR-126a(+) MDSCs (DOX-MDSC)...
June 27, 2016: Oncogene
https://www.readbyqxmd.com/read/27225830/nlrp3-deficiency-reduces-macrophage-interleukin-10-production-and-enhances-the-susceptibility-to-doxorubicin-induced-cardiotoxicity
#8
Motoi Kobayashi, Fumitake Usui, Tadayoshi Karasawa, Akira Kawashima, Hiroaki Kimura, Yoshiko Mizushina, Koumei Shirasuna, Hiroaki Mizukami, Tadashi Kasahara, Naoyuki Hasebe, Masafumi Takahashi
NLRP3 inflammasomes recognize non-microbial danger signals and induce release of proinflammatory cytokine interleukin (IL)-1β, leading to sterile inflammation in cardiovascular disease. Because sterile inflammation is involved in doxorubicin (Dox)-induced cardiotoxicity, we investigated the role of NLRP3 inflammasomes in Dox-induced cardiotoxicity. Cardiac dysfunction and injury were induced by low-dose Dox (15 mg/kg) administration in NLRP3-deficient (NLRP3(-/-)) mice but not in wild-type (WT) and IL-1β(-/-) mice, indicating that NLRP3 deficiency enhanced the susceptibility to Dox-induced cardiotoxicity independent of IL-1β...
2016: Scientific Reports
https://www.readbyqxmd.com/read/26819801/association-between-chemotherapy-response-assays-and-subsets-of-tumor-infiltrating-lymphocytes-in-gastric-cancer-a-pilot-study
#9
Jee Youn Lee, Taeil Son, Jae-Ho Cheong, Woo Jin Hyung, Sung Hoon Noh, Choong-Bai Kim, Chung-Gyu Park, Hyoung-Il Kim
PURPOSE: The purpose of this pilot study was to evaluate the association between adenosine triphosphate-based chemotherapy response assays (ATP-CRAs) and subsets of tumor infiltrating lymphocytes (TILs) in gastric cancer. MATERIALS AND METHODS: In total, 15 gastric cancer tissue samples were obtained from gastrectomies performed between February 2007 and January 2011. Chemotherapy response assays were performed on tumor cells from these samples using 11 chemotherapeutic agents, including etoposide, doxorubicin, epirubicin, mitomycin, 5-fluorouracil (5-FU), oxaliplatin, irinotecan, docetaxel, paclitaxel, methotrexate, and cisplatin...
December 2015: Journal of Gastric Cancer
https://www.readbyqxmd.com/read/26807765/crocin-protects-against-doxorubicin-induced-myocardial-toxicity-in-rats-through-down-regulation-of-inflammatory-and-apoptic-pathways
#10
Nehal M Elsherbiny, Mohamed F Salama, Eman Said, Mohamed El-Sherbiny, Mohammed M H Al-Gayyar
AIM: The clinical application of the chemotherapeutic agent; Doxorubicin (DOX) is limited by its toxic effects on several body organs. The current study was conducted to evaluate the cardiao-protective effects of crocin, a predominant bioactive constituent of Saffron against DOX-induced myocardial toxicity. METHODS: Adult male Sprague Dawley rats received DOX (3.5 mg/kg twice weekly) for 3 weeks with and without daily crocin (10 and 20 mg/kg, orally) for 3 weeks...
March 5, 2016: Chemico-biological Interactions
https://www.readbyqxmd.com/read/26794446/bclaf1-is-an-important-nf-%C3%AE%C2%BAb-signaling-transducer-and-c-ebp%C3%AE-regulator-in-dna-damage-induced-senescence
#11
A-w Shao, H Sun, Y Geng, Q Peng, P Wang, J Chen, T Xiong, R Cao, J Tang
Inducing senescence in cancer cells is an effective approach to suppress cancer growth, and it contributes significantly to the efficacy of therapeutic drugs. Previous studies indicated that transcription factors NF-κB (nuclear factor κ-light-chain-enhancer of activated B cells) and C/EBPβ (CCAAT/enhancer-binding protein-β) play a critical role in the establishment of senescence by upregulating proinflammatory cytokines, notably interleukin-6 (IL-6) and interleukin-8 (IL-8). However, it is not clear how these two factors are activated in response to senescence-inducing stimuli and subsequently regulate gene transcription...
May 2016: Cell Death and Differentiation
https://www.readbyqxmd.com/read/26780402/inflammatory-mediators-in-a-short-time-mouse-model-of-doxorubicin-induced-cardiotoxicity
#12
Michela Pecoraro, Mariagiovanna Del Pizzo, Stefania Marzocco, Rosalinda Sorrentino, Michele Ciccarelli, Guido Iaccarino, Aldo Pinto, Ada Popolo
Doxorubicin (DOXO) is commonly used to treat a wide range of malignant tumors, but its clinical use is limited by acute and chronic cardiotoxicity. The precise mechanism underlying DOXO-induced cardiotoxicity is still not completely elucidated, but cardiac inflammation seems to be involved. Effects of DOXO on proinflammatory cytokines, inflammatory cell infiltration, and necrosis have been proven only when a functional impairment has already occurred, so this study aimed to investigate the acute effect of DOXO administration in mouse heart...
February 15, 2016: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/26690867/doxorubicin-hyaluronan-conjugated-super-paramagnetic-iron-oxide-nanoparticles-dox-ha-spion-enhanced-cytoplasmic-uptake-of-doxorubicin-and-modulated-apoptosis-il-6-release-and-nf-kappab-activity-in-human-mda-mb-231-breast-cancer-cells
#13
Dinesh Vyas, Nicolas Lopez-Hisijos, Sulakshana Gandhi, M El-Dakdouki, Marc D Basson, Mary F Walsh, X Huang, Arpita K Vyas, Lakshmi S Chaturvedi
Triple negative breast cancer exhibit increased IL-6 expression compared with matched healthy breast tissue and a strong link between inflammation and cancer progression and metastasis has been reported. We investigated whether doxorubicin-hyaluronan-super-paramagnetic iron oxide nanoparticles (DOX-HA-SPION) would show greater therapeutic efficacy in human triple negative breast cancer cells (TNBC) MDA-MB-231, as was recently shown in drug-sensitive and multi-drug-resistant ovarian cancer cells. Therefore, we measured cellular DOX uptake via confocal microscopy; observed morphologic changes: mitochondrial and nuclear changes with electron microscopy, and quantitated apoptosis using FACS analysis after Annexin V and PI staining in MDA-MB-231 cells treated with either DOX alone or DOX-HA-SPION...
September 2015: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/26683520/enhancement-of-adoptive-t-cell-transfer-with-single-low-dose-pretreatment-of-doxorubicin-or-paclitaxel-in-mice
#14
Fei-Ting Hsu, Tzu-Chun Chen, Hui-Yen Chuang, Ya-Fang Chang, Jeng-Jong Hwang
Ex vivo expansion of CD8+ T-cells has been a hindrance for the success of adoptive T cell transfer in clinic. Currently, preconditioning with chemotherapy is used to modulate the patient immunity before ACT, however, the tumor microenvironment beneficial for transferring T cells may also be damaged. Here preconditioning with single low dose of doxorubicin or paclitaxel combined with fewer CD8+ T-cells was investigated to verify whether the same therapeutic efficacy of ACT could be achieved. An E.G7/OT1 animal model that involved adoptive transfer of OVA-specific CD8+ T-cells transduced with a granzyme B promoter-driven firefly luciferase and tomato fluorescent fusion reporter gene was used to evaluate this strategy...
December 29, 2015: Oncotarget
https://www.readbyqxmd.com/read/26650653/self-assembled-cationic-biodegradable-nanoparticles-from-ph-responsive-amino-acid-based-poly-ester-urea-urethane-s-and-their-application-as-a-drug-delivery-vehicle
#15
Mingyu He, Alicia Potuck, Julie C Kohn, Katharina Fung, Cynthia A Reinhart-King, Chih-Chang Chu
The objective of this study is to develop a new family of biodegradable and biologically active copolymers and their subsequent self-assembled cationic nanoparticles as better delivery vehicles for anticancer drugs to achieve the synergism between the cytotoxicity effects of the loaded drugs and the macrophage inflammatory response of the delivery vehicle. This family of cationic nanoparticles was formulated from a new family of amphiphilic cationic Arginine-Leucine (Arg-Leu)-based poly(ester urea urethane) (Arg-Leu PEUU) synthesized from four building blocks (amino acids, diols, glycerol α-monoallyl ether, and 1,6 hexamethylene diisocyanate)...
February 8, 2016: Biomacromolecules
https://www.readbyqxmd.com/read/26373608/hypothalamic-energy-metabolism-is-impaired-by-doxorubicin-independently-of-inflammation-in-non-tumour-bearing-rats
#16
Barbara M M Antunes, Fabio Santos Lira, Gustavo Duarte Pimentel, José Cesar Rosa Neto, Andrea Maculano Esteves, Lila Missae Oyama, Cláudio Teodoro de Souza, Cinara Ludvig Gonçalves, Emilio Luiz Streck, Bruno Rodrigues, Ronaldo Vagner dos Santos, Marco Túlio de Mello
We sought to explore the effects of doxorubicin on inflammatory profiles and energy metabolism in the hypothalamus of rats. To investigate these effects, we formed two groups: a control (C) group and a Doxorubicin (DOXO) group. Sixteen rats were randomly assigned to either the control (C) or DOXO groups. The hypothalamus was collected. The levels of interleukin (IL)-1β, IL-6, IL-10, TNF-α and energy metabolism (malate dehydrogenase, complex I and III activities) were analysed in the hypothalamus. The DOXO group exhibited a decreased body weight (p < 0...
August 2015: Cell Biochemistry and Function
https://www.readbyqxmd.com/read/26315113/rituximab-induced-hmgb1-release-is-associated-with-inhibition-of-stat3-activity-in-human-diffuse-large-b-cell-lymphoma
#17
Tiansuo Zhao, He Ren, Xiuchao Wang, Pengfei Liu, Fan Yan, Wenna Jiang, Yang Li, Jing Li, John G Gribben, Li Jia, Jihui Hao
Treatment with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) has greatly improved clinical outcomes in patients with diffuse large B-cell lymphoma (DLBCL) compared with CHOP. The mechanism of rituximab-induced cell death is poorly understood. We found that rituximab does not enhance the directly killing efficacy of CHOP, as tested on a panel of DLBCL cell lines. Rituximab induced a rapid release of HMGB1 (High mobility group protein B 1). This release is independent of cell death but significantly correlated with an inhibition on STAT3 activity...
September 29, 2015: Oncotarget
https://www.readbyqxmd.com/read/26028030/induction-of-mirna-181a-by-genotoxic-treatments-promotes-chemotherapeutic-resistance-and-metastasis-in-breast-cancer
#18
J Niu, A Xue, Y Chi, J Xue, W Wang, Z Zhao, M Fan, C H Yang, Z-M Shao, L M Pfeffer, J Wu, Z-H Wu
Acquired therapeutic resistance is the major drawback to effective systemic therapies for cancers. Aggressive triple-negative breast cancers (TNBC) develop resistance to chemotherapies rapidly, whereas the underlying mechanisms are not completely understood. Here we show that genotoxic treatments significantly increased the expression of miR-181a in TNBC cells, which enhanced TNBC cell survival and metastasis upon Doxorubicin treatment. Consistently, high miR-181a level associated with poor disease free survival and overall survival after treatments in breast cancer patients...
March 10, 2016: Oncogene
https://www.readbyqxmd.com/read/25955490/zoledronic-acid-enhances-antitumor-efficacy-of-liposomal-doxorubicin
#19
Yoshiyuki Hattori, Kazuhiko Shibuya, Kaori Kojima, Andang Miatmoko, Kumi Kawano, Kei-Ichi Ozaki, Etsuo Yonemochi
Previously, we found that the injection of zoledronic acid (ZOL) into mice bearing tumor induced changes of the vascular structure in the tumor. In this study, we examined whether ZOL treatment could decrease interstitial fluid pressure (IFP) via change of tumor vasculature, and enhance the antitumor efficacy of liposomal doxorubicin (Doxil®). When ZOL solution was injected at 40 µg/mouse per day for three consecutive days into mice bearing murine Lewis lung carcinoma LLC tumor, depletion of macrophages in tumor tissue and decreased density of tumor vasculature were observed...
July 2015: International Journal of Oncology
https://www.readbyqxmd.com/read/25931395/chondroitin-nanocapsules-enhanced-doxorubicin-induced-apoptosis-against-leishmaniasis-via-th1-immune-response
#20
Mohini Chaurasia, Vivek K Pawar, Anil K Jaiswal, Anuradha Dube, Sarvesh K Paliwal, Manish K Chourasia
Current leishmaniasis treatment is strangled due to concealed residence of parasite and reduced host cell mediated immune response. To circumvent above challenges, novel macrophage targeted oily core polymeric shell based doxorubicin (DOX) loaded nanocapsules (NCAPs) were fabricated employing chondroitin sulphate (CHD) for complimentary immunotherapy coupled chemotherapy against leishmaniasis. Excellent encapsulation efficiency along with pH dependent drug release was demonstrated by NCAPs. Improved cell cycle arrest at G1-S phase (1...
August 2015: International Journal of Biological Macromolecules
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