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https://www.readbyqxmd.com/read/29044882/sox2-communicates-with-tregs-through-ccl1-to-promote-the-stemness-property-of-breast-cancer-cells
#1
Yingxi Xu, Xiaoli Dong, Pingping Qi, Yujie Ye, Wenzhi Shen, Liang Leng, Lina Wang, Xuefei Li, Xiaohe Luo, Yanan Chen, Peiqing Sun, Rong Xiang, Na Li
As an important component of tumor microenvrionment, CD4(+) CD25(+) Tregs reduce antitumor immunity, promote angiogenesis and metastasis in breast cancer. However, their function in regulating the "stemness" of tumor cells and the communication between Tregs and cancer stem cells (CSCs) remain elusive. Here, we disclose that the primarily cultured Tregs isolated from breast-tumor-bearing Foxp3-EGFP mouse up-regulate the stemness property of breast cancer cells. Tregs increased the side-population and the ALDH(br) population of mouse breast cancer cells, promoted their sphere formation in a paracrine manner and enhanced the expression of stemness genes, such as Sox2 etc...
October 16, 2017: Stem Cells
https://www.readbyqxmd.com/read/29028842/in-vitro-investigation-of-head-and-neck-cancer-stem-cell-proportions-and-their-changes-following-x-ray-irradiation-as-a-function-of-hpv-status
#2
Paul Reid, Puthenparampil Wilson, Yanrui Li, Loredana G Marcu, Alexander H Staudacher, Michael P Brown, Eva Bezak
INTRODUCTION: Some head and neck squamous cell carcinomas (HNSCC) have a distinct aetiology, which depends on the presence of oncogenic human papilloma virus (HPV). Also, HNSCC contains cancer stem cells (CSCs) that have greater radioresistance and capacity to change replication dynamics in response to irradiation compared to non-clonogenic cells. Since there is limited data on CSCs in HNSCC as a function of HPV status, better understanding of their radiobiology may enable improved treatment outcome...
2017: PloS One
https://www.readbyqxmd.com/read/29026383/association-between-aldh2-glu504lys-polymorphism-and-colorectal-cancer-risk-a-meta-analysis
#3
Jiang Xinhua, Zhao Yanfei
BACKGROUND: The findings from studies on the relationship between aldehyde dehydrogenases(ALDH) gene Glu504Lys polymorphism and colorectal cancer(CRC) were inconsistent. OBJECTIVES: The aim of this meta-analysis was to assess ALDH gene Glu504Lys polymorphism and CRC risk. METHODS: All of the relevant studies were identified from PubMed and Embase database. Statistical analyses were conducted with STATA 12.0 software. Odds ratio (OR) with 95% confidence interval (CI) values were applied to evaluate the strength of the association...
March 2017: African Health Sciences
https://www.readbyqxmd.com/read/28986885/evaluation-and-isolation-of-cancer-stem-cells-using-aldh-activity-assay
#4
Luigi Mele, Davide Liccardo, Virginia Tirino
The aldehyde dehydrogenase (ALDH) is a polymorphic enzyme responsible for the oxidation of aldehydes to carboxylic acids. In this chapter, it is described the role of ALDH in the identification of cancer stem cells (CSCs), having been shown that stem cells express high levels of ALDH. Here, we present a method called ALDEFLUOR assay used for the identification, evaluation, and isolation of normal, cancer stem and progenitor cells.
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28947972/pgc1%C3%AE-induced-by-reactive-oxygen-species-contributes-to-chemoresistance-of-ovarian-cancer-cells
#5
Boyun Kim, Je Won Jung, Jaeyoung Jung, Youngjin Han, Dong Hoon Suh, Hee Seung Kim, Danny N Dhanasekaran, Yong Sang Song
Malignant cells are subjected to high levels of oxidative stress that arise from the increased production of reactive oxygen species (ROS) due to their altered metabolism. They activate antioxidant mechanisms to relieve the oxidative stress, and thereby acquire resistance to chemotherapeutic agents. In the present study, we found that PGC1α, a key molecule that both increases mitochondrial biogenesis and activates antioxidant enzymes, enhances chemoresistance in response to ROS generated by exposure of cells to ovarian sphere-forming culture conditions...
September 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28937653/differential-functional-roles-of-aldh1a1-and-aldh1a3-in-mediating-metastatic-behavior-and-therapy-resistance-of-human-breast-cancer-cells
#6
Alysha K Croker, Mauricio Rodriguez-Torres, Ying Xia, Siddika Pardhan, Hon Sing Leong, John D Lewis, Alison L Allan
Previous studies indicate that breast cancer cells with high aldehyde dehydrogenase (ALDH) activity and CD44 expression (ALDH(hi)CD44⁺) contribute to metastasis and therapy resistance, and that ALDH1 correlates with poor outcome in breast cancer patients. The current study hypothesized that ALDH1 functionally contributes to breast cancer metastatic behavior and therapy resistance. Expression of ALDH1A1 or ALDH1A3 was knocked down in MDA-MB-468 and SUM159 human breast cancer cells using siRNA. Resulting impacts on ALDH activity (Aldefluor(®) assay); metastatic behavior and therapy response in vitro (proliferation/adhesion/migration/colony formation/chemotherapy and radiation) and extravasation/metastasis in vivo (chick choroiallantoic membrane assay) was assessed...
September 22, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28930164/liver-cancer-molecular-characterization-clonal-evolution-and-cancer-stem-cells
#7
REVIEW
Germana Castelli, Elvira Pelosi, Ugo Testa
Liver cancer is the second most common cause of cancer-related death. The major forms of primary liver cancer are hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (iCCA). Both these tumors develop against a background of cirrhotic liver, non-alcoholic fatty liver disease, chronic liver damage and fibrosis. HCC is a heterogeneous disease which usually develops within liver cirrhosis related to various etiologies: hepatitis B virus (HBV) infection (frequent in Asia and Africa), hepatitis C virus (HCV), chronic alcohol abuse, or metabolic syndrome (frequent in Western countries)...
September 20, 2017: Cancers
https://www.readbyqxmd.com/read/28927099/interleukin-6-identified-as-an-important-factor-in-hypoxia-and-aldehyde-dehydrogenase-based-gefitinib-adaptive-resistance-in-non-small-cell-lung-cancer-cells
#8
Shi-Min An, Hui-Min Lei, Xu-Ping Ding, Fan Sun, Chun Zhang, Ya-Bin Tang, Hong-Zhuan Chen, Ying Shen, Liang Zhu
Gefitinib resistance and relapse of the disease were the greatest challenges facing clinical therapy of non-small-cell lung cancer (NSCLC). Of note, regarding the hypoxia condition in solid tumor tissues in vivo, roles of hypoxia in gefitinib adaptive resistance and its association with lung cancer stem cells (LCSCs) have not been fully elucidated. In the present study, the role of hypoxia in gefitinib adaptive resistance and its association with aldehyde dehydrogenase (ALDH)-based LCSC gefitinib resistance were comparatively studied using RNA-sequencing (RNA-seq) technology...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28912842/a-reliable-method-for-the-sorting-and-identification-of-aldh-high-cancer-stem-cells-by-flow-cytometry
#9
Zhengwei Leng, Zhao Yang, Lifa Li, Xiaorong Zhong, He Zhou, Yong Li, Gang Yang, Guangjun Zhang, Yongfu Xiong, Tong Zhou, Jianshui Li, Dongsheng Wang, Jingdong Li
Cancer stem cells (CSCs) are a rare tumorigenic population of cells found in multiple types of cancer. It has been suggested that CSCs are responsible for cancer drug resistance, metastasis and recurrence. Therefore, it is important to develop techniques to correctly sort and identify CSCs. In the current study, the sorting and identification of aldehyde dehydrogenase high (ALDH(high)) CSCs was performed using flow cytometry. Cells from three colon cancer cell lines were cultured in serum-free medium to obtain CSCs-enriched spheroid cells...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28912540/sox9-regulates-cancer-stem-like-properties-and-metastatic-potential-of-single-walled-carbon-nanotube-exposed-cells
#10
Maria A Voronkova, Sudjit Luanpitpong, Liying Wang Rojanasakul, Vincent Castranova, Cerasela Zoica Dinu, Heimo Riedel, Yon Rojanasakul
Engineered nanomaterials hold great promise for the future development of innovative products but their adverse health effects are a major concern. Recent studies have indicated that certain nanomaterials, including carbon nanotubes (CNTs), may be carcinogenic. However, the underlying mechanisms behind their potential malignant properties remain unclear. In this study, we linked SOX9, a stem cell associated transcription factor, to the neoplastic-like properties of human lung epithelial cells chronically exposed to a low-dose of single-walled carbon nanotubes (SWCNTs)...
September 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28881734/targeting-aldehyde-dehydrogenase-activity-in-head-and-neck-squamous-cell-carcinoma-with-a-novel-small-molecule-inhibitor
#11
Jeewon Kim, June Ho Shin, Che-Hong Chen, Leslie Cruz, Lovisa Farnebo, Jieying Yang, Paula Borges, Gugene Kang, Daria Mochly-Rosen, John B Sunwoo
Chemoresistant cancer cells express high levels of aldehyde dehydrogenases (ALDHs), particularly in head and neck squamous cell carcinoma (HNSCC). The ALDH family of enzymes detoxify both exogenous and endogenous aldehydes. Since many chemotherapeutic agents, such as cisplatin, result in the generation of cytotoxic aldehydes and oxidative stress, we hypothesized that cells expressing high levels of ALDH may be more chemoresistant due to their increased detoxifying capacity and that inhibitors of ALDHs may sensitize them to these drugs...
August 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28881576/inhibition-of-pi3k-akt-mtor-signaling-in-pi3kr2-overexpressing-colon-cancer-stem-cells-reduces-tumor-growth-due-to-apoptosis
#12
Sugong Chen, Robert C Fisher, Steven Signs, L Alex Molina, Anitha K Shenoy, Maria-Cecilia Lopez, Henry V Baker, John M Koomen, Yi Chen, Haley Gittleman, Jill Barnholtz-Sloan, Annamarie Berg, Henry D Appelman, Emina H Huang
In sporadic colon cancer, colon cancer stem cells (CCSCs) initiate tumorigenesis and may contribute to late disease recurrences and metastases. We previously showed that aldehyde dehydrogenase (ALDH) activity (as indicated by the ALDEFLUOR(®) assay) is an effective marker for highly enriching CCSCs for further evaluation. Here, we used comparative transcriptome and proteome approaches to identify signaling pathways overrepresented in the CCSC population. We found overexpression of several components of the phosphoinositide 3-kinase (PI3K)/Akt/mechanistic target of rapamycin (mTOR) signaling pathway, including PI3KR2, a regulatory subunit of PI3K...
August 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28881356/aldehyde-dehydrogenase-1b1-a-novel-immunohistological-marker-for-colorectal-cancer
#13
Akiko Matsumoto, John Arcaroli, Ying Chen, Maura Gasparetto, Veronique Neumeister, David C Thompson, Surendra Singh, Clayton Smith, Wells Messersmith, Vasilis Vasiliou
BACKGROUND: Aldehyde dehydrogenase (ALDH) 1A1 is an immunohistological biomarker of various solid tumours, but has not been successfully proved as a colorectal cancer (CRC) marker. We recently reported that ALDH1B1, which has functional roles in tumourigenesis, may be a better CRC marker than ALDH1A1. METHODS: Human CRC explants and cell lines were analysed to identify candidate CRC markers from eight ALDH isozymes including ALDH1A1 and ALDH1B1. A tissue microarray, including paired specimens of normal and tumour tissues, was subsequently analysed to determine if candidate ALDHs could distinguish CRC from normal tissue...
September 7, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28878571/ribonucleic-acid-interference-knockdown-of-il-6-enhances-the-efficacy-of-cisplatin-in-laryngeal-cancer-stem-cells-by-down-regulating-the-il-6-stat3-hif1-pathway
#14
Qiang Fu, Pengruofeng Liu, Xiumei Sun, Shanshan Huang, Fengchan Han, Lili Zhang, Yannan Xu, Tingyan Liu
BACKGROUND: Cisplatin has been used in the treatment of many cancers, including laryngeal cancer; however, its efficacy can be reduced due to the development of drug resistance. This study aimed to investigate whether interleukin-6 (IL-6) knockdown may enhance the efficacy of cisplatin in laryngeal cancer stem cells (CSC) and the potential involvement of the signal transducer and activator of transcription 3 (STAT3) and hypoxia-inducible factor 1 (HIF1) in this effect. METHODS: The ALDH+ and CD44+ CSC in Hep2 human laryngeal squamous cancer cells were identified by the fluorescence-activated cell sorting technique...
2017: Cancer Cell International
https://www.readbyqxmd.com/read/28875004/a-comparative-cytotoxic-evaluation-of-disulfiram-encapsulated-plga-nanoparticles-on-mcf-7-cells
#15
Hamidreza Fasehee, Ardeshir Ghavamzadeh, Kamran Alimoghaddam, Seyed-Hamidollah Ghaffari, Shahab Faghihi
Background: Disulfiram is oral aldehyde dehydrogenase (ALDH) inhibitor that has been used in the treatment of alcoholism. Recent studies show that this drug has anticancer properties; however, its rapid degradation has limited its clinical application. Encapsulation of disulfiram polymeric nanoparticles (NPs) may improve its anticancer activities and protect rapid degradation of the drug. Materials andMethods: A poly (lactide-co-Glycolide) (PLGA) was developed for encapsulation of disulfiram and its delivery into breast cancer cells...
April 1, 2017: International Journal of Hematology-oncology and Stem Cell Research
https://www.readbyqxmd.com/read/28870918/the-diagnostic-significance-of-serum-alcohol-dehydrogenase-isoenzymes-and-aldehyde-dehydrogenase-activity-in-prostate-cancer-patients
#16
Karolina Orywal, Wojciech Jelski, Tadeusz Werel, Maciej Szmitkowski
BACKGROUND/AIM: The aim of this study was to investigate a potential role of alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) as tumor markers for prostate cancer (PCa). MATERIALS AND METHODS: Serum samples were obtained from 52 patients with PCa, 34 patients with benign prostatic hyperplasia (BPH) and 60 healthy subjects. Class III and IV of ADH and total ADH activity were measured by the photometric method. For measurement of class I and II ADH and ALDH activity, the fluorometric method was employed...
September 2017: Anticancer Research
https://www.readbyqxmd.com/read/28864067/a-novel-chemoradiation-targeting-stem-and-nonstem-pancreatic-cancer-cells-by-repurposing-disulfiram
#17
Juan Cong, Yangyang Wang, Xiao Zhang, Nan Zhang, Ling Liu, Klara Soukup, Theodoros Michelakos, Theodore Hong, Albert DeLeo, Lei Cai, Francesco Sabbatino, Soldano Ferrone, Hang Lee, Vera Levina, Bryan Fuchs, Kenneth Tanabe, Keith Lillemoe, Cristina Ferrone, Xinhui Wang
Pancreatic ductal adenocarcinoma (PDAC) has a 5-year relative survival rate of 8% and is projected to be the second leading cause of cancer death by 2030, underscoring the urgency to develop new strategies to improve current therapeutic modalities for PDAC. Targeting pancreatic cancer stem cells (PCSCs), which are resistant to radiation and chemotherapy, is a promising strategy. A novel approach which can be readily clinically translated is to repurpose disulfiram (DSF), a drug for treating alcoholism, to target PCSCs...
August 30, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28844650/characterization-of-fadu-r-a-radioresistant-head-and-neck-cancer-cell-line-and-cancer-stem-cells
#18
Kwang-Jae Cho, Eun-Ji Park, Min-Sik Kim, Young-Hoon Joo
OBJECTIVES: The aim of this study was to evaluate the impact of CSC on insensitivity to radiotherapy in HNSCC. METHODS: A radioresistant cell line, FaDu-R, was established using fractionated ionizing radiation. Cells with high and low CD44/ALDH activity were isolated. RESULTS: FaDu-R cells demonstrated significantly increased cell viability after radiation exposure compared with parental cells. CD44(high)/ALDH(high) FaDu-R cells demonstrated significantly faster wound closure (p<0...
August 24, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/28842317/effective-treatment-of-drug-resistant-recurrent-breast-tumors-harboring-cancer-stem-like-cells-by-staurosporine-epirubicin-co-loaded-polymeric-micelles
#19
Juanjuan Zhang, Hiroaki Kinoh, Louise Hespel, Xueying Liu, Sabina Quader, John Martin, Tsukasa Chida, Horacio Cabral, Kazunori Kataoka
Breast cancer recurrence and resistance are associated with cancer stem-like cell (CSC) sub-populations. As conventional therapies fail to treat CSCs, institution of novel therapeutic strategies capable of eradicating both cancer cells and CSCs is central for achieving effective treatments with long-term survival. Here, we studied the ability of polymeric micelles cooperatively loading the cytotoxic drug epirubicin (Epi) and the CSC inhibitor staurosporine (STS) to treat breast tumors, particularly when tumors relapsed after chemotherapy...
October 28, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28837080/activation-of-matrix-hyaluronan-mediated-cd44-signaling-epigenetic-regulation-and-chemoresistance-in-head-and-neck-cancer-stem-cells
#20
REVIEW
Lilly Y W Bourguignon, Christine Earle, Marisa Shiina
Head and neck squamous cell carcinoma (HNSCC) is a solid tumor composed by a genotypically and phenotypically heterogeneous population of neoplastic cells types. High recurrence rate and regional metastases lead to major morbidity and mortality. Recently, many studies have focused on cellular and molecular mechanisms of tumor progression that can help to predict prognosis and to choose the best therapeutic approach for HNSCC patients. Hyaluronan (HA), an important glycosaminoglycan component of the extracellular matrix (ECM), and its major cell surface receptor, CD44, have been suggested to be important cellular mediators influencing tumor progression and treatment resistance in head and neck cancer...
August 24, 2017: International Journal of Molecular Sciences
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