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https://www.readbyqxmd.com/read/29225319/effects-of-aerobic-exercise-combined-with-panaxatriol-derived-from-ginseng-on-insulin-resistance-and-skeletal-muscle-mass-in-type-2-diabetic-mice
#1
Yusuke Takamura, Mitsuru Nomura, Akira Uchiyama, Satoshi Fujita
Insulin resistance reduces insulin-induced muscle protein synthesis and accelerates muscle protein degradation. Ginseng ingestion has been reported to improve insulin resistance through the phosphoinositide 3-kinase (PI3K)/Akt signaling pathway. We hypothesized that panaxatriol (PT) derived from ginseng in combination with aerobic exercise (EX) may further promote protein synthesis and suppress protein degradation, and subsequently maintain muscle mass through the amelioration of insulin resistance. KKAy insulin-resistant mice were divided into control, panaxatriol only (PT), exercise only (EX), and EX+PT groups...
2017: Journal of Nutritional Science and Vitaminology
https://www.readbyqxmd.com/read/29218951/-research-on-compatibility-of-prescriptions-including-ginseng-radix-et-rhizoma-and-trogopterus-dung-based-on-complex-network-analysis
#2
Meng-Wen Li, Xin-Sheng Fan, Ling-Shan Zhang, Cong-Jun Wang
The applications of prescriptions including Ginseng Radix et Rhizoma and Trogopterus Dung in contemporary literatures from 1949 to 2016 are compiled and the data mining techniques containing scale-free complex network method are utilized to explore its practical characteristics, with comparison between modern and ancient ones. The results indicate that malignant neoplasms, coronary heart disease which present Qi deficiency and blood stasis type are the main diseases treated by prescriptions including Ginseng Radix et Rhizoma and Trogopterus Dung according to the reports during 1949 to 2016...
September 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29215592/natural-korean-medicine-dang-gui-biosynthesis-effective-extraction-and-formulations-of-major-active-pyranocoumarins-their-molecular-action-mechanism-in-cancer-and-other-biological-activities
#3
REVIEW
Chinreddy Subramanyam Reddy, Seong Cheol Kim, Mok Hur, Yeon Bok Kim, Chun Geon Park, Woo Moon Lee, Jae Ki Jang, Sung Cheol Koo
Angelica gigas Nakai (AGN) is a crucial oriental medicinal herb that grows especially in Korea and the Far-East countries. It contains chemically active compounds like pyranocoumarins, polyacetylenes and essential oils, which might be useful for treatment of several chronic diseases. It has been used for centuries as a traditional medicine in Southeast Asia, but in Western countries is used as a functional food and a major ingredient of several herbal products. The genus Angelica is also known as 'female ginseng' due to its critical therapeutic role in female afflictions, such as gynecological problems...
December 7, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29207539/comprehensive-profiling-and-quantification-of-ginsenosides-in-the-root-stem-leaf-and-berry-of-panax-ginseng-by-uplc-qtof-ms
#4
Jae Won Lee, Bo-Ram Choi, Young-Chang Kim, Doo Jin Choi, Young-Seob Lee, Geum-Soog Kim, Nam-In Baek, Seung-Yu Kim, Dae Young Lee
The effective production and usage of ginsenosides, given their distinct pharmacological effects, are receiving increasing amounts of attention. As the ginsenosides content differs in different parts of Panax ginseng, we wanted to assess and compare the ginsenosides content in the ginseng roots, leave, stems, and berries. To extract the ginsenosides, 70% (v/v) methanol was used. The optimal ultra-performance liquid chromatography-quadrupole time of flight mass spectrometry (UPLC-QTOF/MS) method was used to profile various ginsenosides from the different parts of P...
December 4, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29207398/involvement-of-n-methyl-d-aspartic-acid-receptor-and-dl-%C3%AE-amino-3-hydroxy-5-methyl-4-isoxazole-propionic-acid-receptor-in-ginsenosides-rb1-and-rb3-against-oxygen-glucose-deprivation-induced-injury-in-hippocampal-slices-from-rat
#5
Shan Jiang, De-Fang Fang, Ying Chen
OBJECTIVE: Ginsenosides, Rb1 and Rb3, are the major protopanaxadiol components of ginseng saponin. In the present study, the influences of ginsenosides Rb1 and Rb3 on N-methyl-D-aspartic acid (NMDA) receptor or DL-α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptor-mediated synaptic transmission after oxygen-glucose deprivation (OGD) were investigated. METHODS: NMDA receptor population spike (NMDA-PS) or AMPA receptor-mediated population spike (AMPA-PS) was recorded in the CA1 pyramidal cell layer of rat hippocampal slices by electrophysiological techniques...
December 5, 2017: Pharmacology
https://www.readbyqxmd.com/read/29207171/ginsenoside-rh2-inhibits-human-a172-glioma-cell-proliferation-and-induces-cell-cycle-arrest-status-via-modulating-akt-signaling-pathway
#6
Kai-Fei Li, Chun-Min Kang, Xiao-Feng Yin, Hai-Xia Li, Zhuo-Yu Chen, Yao Li, Qiong Zhang, Yu-Rong Qiu
Ginsenoside Rh2 (G‑Rh2), the main bioactive component in American ginseng, is known to exert a wide variety of biological activities. Accumulating evidence suggests that G‑Rh2 inhibits cell proliferation and induces apoptosis of tumor cells. However, the possible mechanism through which G‑Rh2 exerts its action on malignant glioma cells have not been completely elucidated. The findings of the present study demonstrated that G‑Rh2 decreased the viability of glioma cells in a dose‑ and time‑dependent manner, and induced cell cycle arrest...
December 5, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29207044/ginsenoside-rg1-inhibits-inflammatory-responses-via-modulation-of-the-nuclear-factor%C3%A2-%C3%AE%C2%BAb-pathway-and-inhibition-of-inflammasome-activation-in-alcoholic-hepatitis
#7
Jiajun Li, Cheng Yang, Shu Zhang, Shu Liu, Luole Zhao, Huan Luo, Yatang Chen, Wenxiang Huang
Ginsenoside Rg1 (G‑Rg1) is an active ingredient of Panax ginseng, which has previously been reported to attenuate alcohol‑induced hepatic damage; however, the underlying mechanisms remain largely unknown. The present study aimed to investigate the protective effects of G‑Rg1 on alcohol‑induced cell injury in vitro and on a rat model of alcoholic hepatitis in vivo. For the in vitro model, L‑O2 cells were incubated with ethanol in the presence or absence of G‑Rg1. For the in vivo model, rats were administered ethanol by intragastric injection and were treated with G‑Rg1, or dexamethasone as a control...
November 29, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29205862/determination-of-the-transformation-of-ginsenosides-in-ginseng-radix-et-rhizoma-during-decoction-with-water-using-ultra-fast-liquid-chromatography-coupled-with-tandem-mass-spectrometry
#8
Lei Zhang, Qi-Le Zhou, Xiu-Wei Yang
This study was conducted to determine the variations of ginsenosides in Ginseng Radix et Rhizoma when using different preparation solvents, and explore the major factors for changes. With an established ultra-fast liquid chromatography coupled with tandem mass spectrometry method which could quantify 52 ginsenosides, the extraction differences were characterized and compared using different solvents (water, 70% aqueous ethanol and ethanol). Subsequently, a series of aqueous solutions with different pH were prepared to test the influence of pH to the changes of ginsenosides...
December 5, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/29200734/toxicity-and-detoxification-effects-of-herbal-caowu-via-ultra-performance-liquid-chromatography-mass-spectrometry-metabolomics-analyzed-using-pattern-recognition-method
#9
Yan Yan, Aihua Zhang, Hui Dong, Guangli Yan, Hui Sun, Xiuhong Wu, Ying Han, Xijun Wang
Background: Caowu (Radix Aconiti kusnezoffii, CW), the root of Aconitum kusnezoffii Reichb., has widely used clinically in rheumatic arthritis, painful joints, and tumors for thousands of years. However, the toxicity of heart and central nervous system induced by CW still limited the application. Materials and Methods: Metabolomics was performed to identify the sensitive and reliable biomarkers and to characterize the phenotypically biochemical perturbations and potential mechanisms of CW-induced toxicity, and the detoxification by combinatorial intervention of CW with Gancao (Radix Glycyrrhizae) (CG), Baishao (Radix Paeoniae Alba) (CB), and Renshen (Radix Ginseng) (CR) was also analyzed by pattern recognition methods...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29199005/ginsenoside-rg3-sensitizes-hypoxic-lung-cancer-cells-to-cisplatin-via-blocking-of-nf-%C3%AE%C2%BAb-mediated-epithelial-mesenchymal-transition-and-stemness
#10
Jingjing Wang, Lili Tian, Muhammad Noman Khan, Li Zhang, Qun Chen, Yi Zhao, Qiu Yan, Li Fu, Jiwei Liu
Cisplatin is a first line chemotherapy in lung cancer, but decreased susceptibility may limit its application. In solid tumors, hypoxia alters the microenvironment and is associated with proliferation, metastasis, and drug sensitivity. The hypoxia-induced desensitization of cisplatin is not clearly elucidated. 20 (R)-Ginsenoside (Rg3), the traditional Chinese medicine, is extracted from ginseng and has antitumor activities. In this study, we evaluated if Rg3 is effective in improving cisplatin sensitivity by blocking hypoxia...
November 30, 2017: Cancer Letters
https://www.readbyqxmd.com/read/29196903/concurrent-use-of-prescription-drugs-and-herbal-medicinal-products-in-older-adults-a-systematic-review
#11
REVIEW
Taofikat B Agbabiaka, Barbara Wider, Leala K Watson, Claire Goodman
BACKGROUND: The use of herbal medicinal products (HMPs) is common among older adults; however, little is known about concurrent use with prescription drugs, as well as potential interactions associated with such combinations. OBJECTIVE: The aim of this systematic review was to identify and evaluate the literature on concurrent prescription and HMP use among older adults to assess prevalence, patterns, potential interactions and factors associated with this use. METHODS: Systematic searches were conducted in the MEDLINE, PsycINFO, EMBASE, CINAHL, AMED, Web of Science and Cochrane databases from inception to May 2017 for studies reporting concurrent use of prescription medicines with HMPs in adults ≥ 65 years of age...
December 1, 2017: Drugs & Aging
https://www.readbyqxmd.com/read/29195948/effects-of-soil-type-and-organic-fertilizers-on-fatty-acids-and-vitamin-e-in-korean-ginseng-panax-ginseng-meyer
#12
Ill-Min Chung, Jae-Kwang Kim, Jin-Hee Yang, Ji-Hee Lee, Sung-Kyu Park, Na-Young Son, Seung-Hyun Kim
This study examined the effects of soil type and fertilizer regimes on variations in fatty acids (FAs) and vitamin E (Vit-E) in 6-year-old ginseng roots. We observed significant variation in both FA and Vit-E contents owing to the type and quantity of organic fertilizer used in each soil type during cultivation. Unsaturated FAs were approximately 2.7-fold higher in ginseng than in saturated FAs. Linoleic, palmitic, and oleic acids were the most abundant FAs detected in ginseng roots. Additionally, α-tocopherol was the major Vit-E detected...
December 2017: Food Research International
https://www.readbyqxmd.com/read/29192434/-research-on-technology-regulation-of-non-polluted-cultivation-and-strategies-of-panax-ginseng-cultivation-in-farmland
#13
Liang Shen, Xi-Wen Li, Jiang Xu, Lin-Lin Dong, Nai-Wu Zhang, Fujihara Naoli, Shi-Lin Chen
As the limit of the usage of available forest land, cultivated ginseng in the farmland would become the mainly Panax ginseng planting mode, meanwhile the non-polluted production technology would be the mainly development direction in the future. In this study, the non-polluted cultivation technology system of P. ginseng was established based on the research results of field investigation in the cultivated regions. The system includes suitable planting regions selecting, planting method, field management, pest control, harvesting & processing, and quality control...
September 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29188056/molecular-cloning-expression-purification-and-functional-characterization-of-an-antifungal-cyclophilin-protein-from-panax-ginseng
#14
Hui Zhang, Jiawen Wang, Shuaijun Li, Siming Wang, Meichen Liu, Weinan Wang, Yu Zhao
Cyclophilins (CyPs), a member of peptidyl-prolyl cis-trans isomerases (PPIases), are ubiquitously distributed in organisms such as bacteria, yeast, plants and animals. CyPs have diverse biological functions, with some exhibiting antifungal and antiviral activities. In this study, Panax ginseng cyclophilin (pgCyP), a novel gene encoding an antifungal protein from Panax ginseng, was cloned, and its protein product was expressed in Escherichia coli, and then fractionated by affinity chromatography. The open reading frame of the pgCyP full-length coding sequence was found to encode a single-domain CyP-like protein of 174 amino residues with a calculated molecular weight of 18...
December 2017: Biomedical Reports
https://www.readbyqxmd.com/read/29186965/genome-sequence-of-a-distinct-watermelon-mosaic-virus-identified-from-ginseng-panax-ginseng-transcriptome
#15
D Park, H Kim, Y Hahn
Watermelon mosaic virus (WMV) is a member of the genus Potyvirus, which is the largest genus of plant viruses. WMV is a significant pathogen of crop plants, including Cucurbitaceae species. A WMV strain, designated as WMV-Pg, was identified in transcriptome data collected from ginseng (Panax ginseng) root. WMV-Pg showed 84% nucleotide sequence identity and 91% amino acid sequence identity with its closest related virus, WMV-Fr. A phylogenetic analysis of WMV-Pg with other WMVs and soybean mosaic viruses (SMVs) indicated that WMV-Pg is a distinct subtype of the WMV/SMV group of the genus Potyvirus in the family Potyviridae...
2017: Acta Virologica
https://www.readbyqxmd.com/read/29184939/consumption-of-plant-food-supplements-in-the-netherlands
#16
Suzanne M F Jeurissen, Elly J M Buurma-Rethans, Marja H Beukers, Martine Jansen-van der Vliet, Caroline T M van Rossum, R Corinne Sprong
The use of food supplements containing herbs or other botanical ingredients (plant food supplements, PFS) is on the rise. In some cases, PFS can contain compounds that are toxic and may pose a health risk. To assess the potential health risks, information on the consumption of PFS is required, however, this was lacking for the Netherlands. In the current study, the consumption of PFS was investigated for several subgroups in the Dutch population, including children. Data from the Dutch National Food Consumption Surveys were used to get a first impression on the consumption of PFS...
November 29, 2017: Food & Function
https://www.readbyqxmd.com/read/29180961/ginsenoside-rb1-mediated-anti-angiogenesis-via-regulating-pedf-and-mir-33a-through-the-activation-of-ppar-%C3%AE-pathway
#17
Huixia Lu, Xunian Zhou, Hoi-Hin Kwok, Mei Dong, Zhaoqiang Liu, Po-Ying Poon, Xiaorong Luan, Ricky Ngok-Shun Wong
Angiogenesis is the formation of new blood vessels from the existing vasculature, which is involved in multiple biological processes, including atherosclerosis, ischemic heart disease, and cancer. Ginsenoside-Rb1 (Rb1), the most abundant ginsenoside isolated form Panax ginseng, has been identified as a promising anti-angiogenic agent via the up-regulation of PEDF. However, the underlying molecular mechanisms still unknown. In the present study, human umbilical vein endothelial cells (HUVECs) were selected to perform in vitro assays...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29176690/fungal-endophytes-inhabiting-mountain-cultivated-ginseng-panax-ginseng-meyer-diversity-and-biocontrol-activity-against-ginseng-pathogens
#18
Young-Hwan Park, Yoosam Kim, Ratnesh Chandra Mishra, Hanhong Bae
Fungal endophytes isolated from mountain-cultivated ginseng (MCG, Panax ginseng Meyer) were explored for their diversity and biocontrol activity against ginseng pathogens (Alternaria panax, Botrytis cinerea, Cylindrocarpon destructans, Pythium sp. and Rhizoctonia solani). A total of 1,300 isolates were isolated from three tissues (root, stem and leaf) from MCGs grown in 24 different geographic locations in Korea. In total, 129 different fungal isolates were authenticated by molecular identification based on internal transcribed spacer (ITS) sequences...
November 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29171228/-molecular-cloning-bacterial-expression-analysis-and-functional-characterization-of-pathogenesis-related-pr10-2-gene-in-panax-notoginseng
#19
Dan Yang, Yi Bao, Li-Mei Chen, Xiu-Ming Cui, Kun-Zhi Li
Base on the transcriptome analysis and RT-PCR techniques,a pathogenesis-related protein 10 gene was isolated from Panax notoginseng root and named as PnPR10-2. Bioinformatics and phylogenetic trees analysis revealed that open reading frame (ORF) of PnPR10-2 was 465 bp in length,encoding 154 amino acids,containing one typical conserved domain of pathogenesis related protein Bet v I family, and showed high similarity with that from P. ginseng. The recombinant expressed plasmid pET32a(+)-PnPR10-2 was expressed in Escherichia coli BL21...
August 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29169725/ginsenoside-rg3-inhibits-colorectal-tumor-growth-via-down-regulation-of-c-ebp%C3%AE-nf-%C3%AE%C2%BAb-signaling
#20
Xiaolai Yang, Jian Zou, Hongyi Cai, Xiaoling Huang, Xiongfei Yang, Dexi Guo, Yongxiao Cao
Colorectal cancer (CRC), the third most frequent occurred cancer, is associated with high mortality and extremely poor prognosis. Ginsenoside Rg3 (Rg3), one of the pharmacologically active components of traditional Chinese herbal medicine Panax ginseng, exerts antitumor effects against several types of cancer growth, including colorectal cancer. However, the detailed molecular mechanisms and particularly the signaling pathways that are decisive in this process are not yet fully elucidated. The present study was carried out to determine the antitumor effects of Rg3 using human colorectal cells in vitro and Xenograft tumor model of human colon cancer in vivo...
November 20, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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