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Vinorelbin mobilization

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https://www.readbyqxmd.com/read/27382096/bendamustine-in-combination-with-gemcitabine-and-vinorelbine-is-an-effective-regimen-as-induction-chemotherapy-before-autologous-stem-cell-transplantation-for-relapsed-or-refractory-hodgkin-lymphoma-final-results-of-a-multicenter-phase-ii-study
#1
Armando Santoro, Rita Mazza, Alessandro Pulsoni, Alessandro Re, Maurizio Bonfichi, Vittorio Ruggero Zilioli, Flavia Salvi, Francesco Merli, Antonella Anastasia, Stefano Luminari, Giorgia Annechini, Manuel Gotti, Annalisa Peli, Anna Marina Liberati, Nicola Di Renzo, Luca Castagna, Laura Giordano, Carmelo Carlo-Stella
PURPOSE: This multicenter, open-label, phase II study evaluated the combination of bendamustine, gemcitabine, and vinorelbine (BeGEV) as induction therapy before autologous stem-cell transplantation (ASCT) in patients with relapsed or refractory Hodgkin lymphoma (HL). PATIENTS AND METHODS: Patients with HL who were refractory to or had relapsed after one previous chemotherapy line were eligible. The primary end point was complete response (CR) rate after four cycles of therapy...
September 20, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/27001243/efficacious-and-save-use-of-biosimilar-filgrastim-for-hematopoietic-progenitor-cell-chemo-mobilization-with-vinorelbine-in-multiple-myeloma-patients
#2
Julia-Tatjana Maul, Frank Stenner-Liewen, Burkhardt Seifert, Sarah Pfrommer, Ulf Petrausch, Michael K Kiessling, Urs Schanz, Gayathri Nair, Axel Mischo, Christian Taverna, Adrian Schmidt, Mario Bargetzi, Roger Stupp, Christoph Renner, Panagiotis Samaras
Biosimilars are increasingly being licensed as equipotent drugs, although efficacy and safety data are not available for all clinical indications. Accordingly, the efficacy of the biosimilar filgrastim Zarzio® combined with vinorelbine for chemo-mobilization of CD34+ hematopoietic progenitor cells (HPC) in patients with multiple myeloma has not been evaluated yet. We compared the efficacy of vinorelbine combined with this biosimilar filgrastim for HPC mobilization to vinorelbine plus original filgrastim (Neupogen®)...
March 22, 2016: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/26294015/stem-cell-mobilization-chemotherapy-with-gemcitabine-is-effective-and-safe-in-myeloma-patients-with-bortezomib-induced-neurotoxicity
#3
Beatrice U Mueller, Sandra Keller, Katja Seipel, Behrouz Mansouri Taleghani, Daniel Rauch, Daniel Betticher, Thomas Egger, Thomas Pabst
Vinorelbine chemotherapy with granulocyte-colony stimulating factor (G-CSF) stimulation is a widely applied non-myelosuppressive mobilization regimen in Switzerland for myeloma patients, but its neurotoxic potential limits its use in patients with bortezomib-induced polyneuropathy. In this single-center study, we alternatively evaluated safety and effectiveness of gemcitabine chemotherapy with G-CSF for mobilization of autologous stem cells. Between March 2012 and February 2013, all bortezomib-pretreated myeloma patients planned to undergo first-line high-dose melphalan chemotherapy received a single dose of 1250 mg/m2 gemcitabine, with G-CSF started on day 4...
May 2016: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/25278456/efficacy-of-vinorelbine-plus-granulocyte-colony-stimulation-factor-for-cd34-hematopoietic-progenitor-cell-mobilization-in-patients-with-multiple-myeloma
#4
Panagiotis Samaras, Sarah Pfrommer, Burkhardt Seifert, Ulf Petrausch, Axel Mischo, Adrian Schmidt, Urs Schanz, Gayathri Nair, Mario Bargetzi, Christian Taverna, Roger Stupp, Frank Stenner-Liewen, Christoph Renner
We aimed to assess the efficacy of vinorelbine plus granulocyte colony-stimulating factor (G-CSF) for chemo-mobilization of CD34(+) hematopoietic progenitor cells (HPC) in patients with multiple myeloma and to identify adverse risk factors for successful mobilization. Vinorelbine 35 mg/m(2) was administered intravenously on day 1 in an outpatient setting. Filgrastim 5 μg/kg body weight (BW) was given twice daily subcutaneously from day 4 until the end of the collection procedure. Leukapheresis was scheduled to start on day 8 and be performed for a maximum of 3 consecutive days until at least 4 × 10(6) CD34(+) cells per kg BW were collected...
January 2015: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/24884311/role-of-plerixafor-in-autologous-stem-cell-mobilization-with-vinorelbine-chemotherapy-and-granulocyte-colony-stimulating-factor-in-patients-with-myeloma-a-phase-ii-study-pav-trial
#5
Andrea Schmid, Dorothea Friess, Behrouz Mansouri Taleghani, Peter Keller, Beatrice U Mueller, Gabriela M Baerlocher, Kurt Leibundgut, Thomas Pabst
Current practice in Switzerland for the mobilization of autologous stem cells in patients with myeloma is combining vinorelbine chemotherapy and granulocyte-colony stimulating factor (G-CSF) cytokine stimulation. We prospectively investigated adding intravenous plerixafor to the vinorelbine/G-CSF combination (VGP), and compared it with vinorelbine/plerixafor (VP) and G-CSF/plerixafor (GP) combinations. In a final cohort (VP-late), plerixafor was given on the first day of CD34 + cells increasing to > 15,000/mL peripheral blood...
March 2015: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/24721203/validated-hilic-ms-ms-assay-for-determination-of-vindesine-in-human-plasma-application-to-a-population-pharmacokinetic-study
#6
Rong-Hua Zhu, Huan-De Li, Hua-Lin Cai, Zhi-Ping Jiang, Ping Xu, Li-Bo Dai, Wen-Xing Peng
The first HILIC-tandem mass spectrometry (MS/MS) method for determination of vindesine (VDS) in human plasma using vinorelbine as an internal standard (IS) has been developed and validated. Plasma samples clean-up consisted of solid phase extraction with a strata™-X column. The compounds were separated on a HILIC column with an isocratic mobile phase consisting of acetonitrile and 15mM ammonium acetate buffer containing 0.15% formic acid (80:20, v/v). The detection was performed on a triple quadrupole tandem mass spectrometer via electrospray positive ionization (ESI(+))...
August 5, 2014: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/24365981/rapid-and-sensitive-liquid-chromatography-coupled-with-electrospray-ionization-tandem-mass-spectrometry-method-for-the-analysis-of-paclitaxel-docetaxel-vinblastine-and-vinorelbine-in-human-plasma
#7
Shouhong Gao, Jingya Zhou, Feng Zhang, Haijun Miao, Yunlei Yun, Jin Feng, Xia Tao, Wansheng Chen
BACKGROUND: A rapid and sensitive analytical method using liquid chromatography coupled with electrospray ionization tandem mass spectrometry (LC-MS/MS) was developed for the determination of paclitaxel, docetaxel, vinblastine, and vinorelbine in human plasma. METHODS: A simple liquid-liquid extraction procedure was applied using only 100-μL plasma. Chromatographic separation of these anticancer drugs was achieved with an isocratic mobile phase consisting of acetonitrile/aqueous buffer (10 mmol/L ammonium acetate and 0...
June 2014: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/21342795/rapid-and-sensitive-determination-of-vinorelbine-in-human-plasma-by-liquid-chromatography-tandem-mass-spectrometry-and-its-pharmacokinetic-application
#8
Jun Qian, Yixuan Wang, Jianhua Chang, Jian Zhang, Jialei Wang, Xichun Hu
Vinorelbine is a semi-synthetic vinca alkaloid with demonstrated high activities against various types of advanced cancer. To support a clinical pharmacokinetic study, a simple, rapid and sensitive method to determine vinorelbine in human plasma was developed using reversed phase liquid chromatography (LC) coupled with electrospray ionization mass spectrometry/mass spectrometry (ESI-MS/MS). Vinorelbine and vinblastine (the internal standard) were extracted from human plasma by one-step liquid-liquid extraction (LLE) with methyl-t-butyl ether...
March 15, 2011: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/21072518/gemcitabine-and-vinorelbine-combination-is-effective-in-both-as-a-salvage-and-mobilization-regimen-in-relapsed-or-refractory-hodgkin-lymphoma-prior-to-asct
#9
Elif Suyanı, Gülsan Türköz Sucak, Şahika Zeynep Akı, Zeynep Arzu Yeğin, Zübeyde Nur Özkurt, Münci Yağcı
We investigated the efficacy of gemcitabine and vinorelbine (Gem/Vin) combination chemotherapy as a salvage and mobilization regimen in relapsed or refractory Hodgkin lymphoma (HL) patients prior to autologous hematopoietic stem cell transplantation. We retrospectively reviewed the data of our relapsed or primary refractory HL patients treated with Gem/Vin regimen which consisted of gemcitabine 1,000 mg/m(2)/day and vinorelbine 30 mg/m(2)/day on days 1, 8, and 15 every 28 days. The overall response rate was 72...
June 2011: Annals of Hematology
https://www.readbyqxmd.com/read/20819300/tlc-and-hplc-methods-to-follow-the-synthesis-of-vinorelbine
#10
Zhao Chunfang, Xiong Yin, Yu Longjiang, Li Shuo, Wu Zeqiang
The thin-layer chromatography (TLC) combined with high-performance liquid chromatography (HPLC) has been proved to be a quick and valid method to detect the intermediates and the end-product created during the chemosynthesis process of vinorelbine (VB). This paper gives a detailed investigation on the results of two determination methods when the condition of the detection changed. It shows that when TLC developer is consisted of petroleum ether, chloroform, acetone, and diethyl amine (23.5:12:2:2.5, v/v/v/v), vinblastine sulfate (VBS), anhydrovinblastine (AHVB), and VB can be separated specifically...
September 2010: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/20641009/sensitive-measurement-of-vinorelbine-in-dog-plasma-by-liquid-chromatography-electrospray-ionization-tandem-mass-spectrometry-utilizing-transitions-from-double-charged-precursor-ions
#11
Makoto Niwa, Takashi Kawashiro
A sensitive high-performance liquid chromatography/tandem mass spectrometry (LC/MS/MS) method for measuring vinorelbine was developed. A 100 µL aliquot of plasma was spiked with deuterium-labeled internal standard and subjected to solid-phase extraction using an Oasis HLB μ-elution plate. Two microliters of the extracted samples was directly injected into LC/MS/MS. Chromatographic separation was achieved on a Capcell Pak C18 UG column (2 × 75 mm) with a gradient elution of methanol (mobile phase B) against 0...
April 2011: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/19169288/efficient-mobilization-of-pbsc-with-vinorelbine-g-csf-in-patients-with-malignant-lymphoma
#12
M Heizmann, A C O'Meara, P R Moosmann, I A F M Heijnen, M Zuberbühler, P Fernandez, J Burger, A Huber, M Wernli, M J Bargetzi
High-dose chemotherapy (HDT) and hematopoietic SCT are effective in patients with relapsing or refractory malignant lymphoma. Collection of sufficient numbers of stem cells is a prerequisite for such a therapy. In a pilot trial, we evaluated the feasibility of stem cell mobilization with vinorelbine/G-CSF in patients with lymphoma, a regimen allowing precise timing and harvesting of sufficient stem cells in myeloma patients. Forty-five patients with lymphoma received vinorelbine 35 mg/m(2) i.v. on day 1 and G-CSF 10 microg/kg/day s...
July 2009: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/17906705/igev-regimen-and-a-fixed-dose-of-lenograstim-an-effective-mobilization-regimen-in-pretreated-hodgkin-s-lymphoma-patients
#13
M Magagnoli, M Spina, M Balzarotti, I Timofeeva, L Isa, M Michieli, R Capizzuto, E Morenghi, L Castagna, U Tirelli, A Santoro
We explored the efficacy of the IGEV regimen (ifosfamide, gemcitabine, vinorelbine and prednisone) combined with a fixed dose of lenograstim (263 mug/day) to mobilize peripheral blood stem cells (PBSCs) in 90 Hodgkin's lymphoma patients. The median total CD34+ cells/mul peak, colony-forming units granulocyte-macrophage and white blood cells for all individual collection sets were 85/mul, 12 x 10(4)/kg and 20 700/mul, respectively. An adequate number of CD34+ cells (more than 3 x 10(6) or 6 x 10(6) CD34+ cells/kg depending on whether single or tandem high-dose chemotherapy was used) were collected in 89 out of 90 (98...
December 2007: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/17229633/ifosfamide-gemcitabine-and-vinorelbine-a-new-induction-regimen-for-refractory-and-relapsed-hodgkin-s-lymphoma
#14
Armando Santoro, Massimo Magagnoli, Michele Spina, Graziella Pinotti, Licia Siracusano, Mariagrazia Michieli, Andrea Nozza, Barbara Sarina, Emanuela Morenghi, Luca Castagna, Umberto Tirelli, Monica Balzarotti
BACKGROUND AND OBJECTIVES: Response to pre-transplant salvage chemotherapy remains the most important prognostic factor for outcome in refractory or relapsed Hodgkin's lymphoma. Results of a new induction regimen are reported in terms of response rates, toxicity, and stem cell mobilization. DESIGN AND METHODS: Ninety-one patients with refractory or relapsed Hodgkin's lymphoma were treated prospectively with a salvage regimen consisting of ifosfamide 2000 mg/m2 on days 1 to 4, gemcitabine 800 mg/m2 on days 1 and 4, vinorelbine 20 mg/m2 on day 1, and prednisolone 100 mg on days 1 to 4 (IGEV)...
January 2007: Haematologica
https://www.readbyqxmd.com/read/17071490/results-of-a-clinical-phase-i-dose-escalation-study-of-cytarabine-in-combination-with-fixed-dose-vinorelbine-paclitaxel-etoposide-and-cisplatin-for-the-treatment-of-relapsed-refractory-lymphoma
#15
Sagar Lonial, Martha Arellano, Donald Hutcherson, Amelia Langston, Christopher Flowers, L T Heffner, Elliott Winton, Mary Jo Lechowicz, Edmund K Waller
Management of relapsed lymphoma depends upon the variables of chemosensitive disease and successful stem cell mobilization. The microtubule specific agents, paclitaxel and vinorelbine, have efficacy in relapsed lymphoma and can enhance stem cell mobilization. We performed a phase I dose-escalation study of cytarabine combined with fixed doses of vinorelbine, paclitaxel, etoposide and cisplatin (VTEPA) for patients with relapsed/refractory lymphoma. The regimen consisted of paclitaxel 175 mg/m2 and vinorelbine 30 mg/m2 on day 1; cisplatin 20 mg/m2 and etoposide 100 mg/m2 over 4 h on days 2 - 5...
October 2006: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/16538502/vinorelbine-plus-intermediate-dose-cyclophosphamide-is-an-effective-and-safe-regimen-for-the-mobilization-of-peripheral-blood-stem-cells-in-patients-with-multiple-myeloma
#16
Mario Annunziata, Maria Celentano, Barbara Pocali, Maria Rosaria D'Amico, Salvatore Palmieri, Assunta Viola, Carolina Copia, Claudio Falco, Luigi Del Vecchio, Felicetto Ferrara
High dose cyclophosphamide (HD-Cy) is commonly used to mobilize stem cells in multiple myeloma (MM). However, timing of collection is variable and incidence of side effects is substantial. We evaluated a combination of vinorelbine (VNB) (25 mg/m(2) day 1) plus Cy (1.5 g/m(2) day 2) and G-CSF as mobilizing regimen in 37 patients with MM. Results were compared to those achieved in 41 previously diagnosed patients mobilized with Cy at 4 g/m(2). Overall, 36/37 patients receiving VNB-Cy (97%) mobilized, as opposed to 40/41 (97%) in the controls (p:0...
June 2006: Annals of Hematology
https://www.readbyqxmd.com/read/16085133/characterization-of-impurities-in-semi-synthetic-vinorelbine-bitartrate-by-hplc-ms-with-mass-spectrometric-shift-technique
#17
Xiaoji Cao, Yuanpo Tai, Cuirong Sun, Kuiwu Wang, Yuanjiang Pan
A simple and sensitive method of high-performance liquid chromatography coupled with electrospray ionization mass spectrometry (HPLC/ESI-MS) was developed to separate and identify impurities in semi-synthetic vinorelbine bitartrate sample. The analytical HPLC was carried out on a reversed-phase C8 column using 0.02 M ammonium formicate buffer (pH 4.2) and methanol (46:54, v/v) as mobile phase at a flow rate of 0.8 ml/min at room temperature and a UV detection at 267 nm. The on-line HPLC/ESI-MS/MS was performed using ion trap analyzer in positive ion mode...
September 1, 2005: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/14703065/dose-dense-vinorelbine-and-paclitaxel-with-granulocyte-colony-stimulating-factor-in-metastatic-breast-cancer-patients-anti-tumor-activity-and-peripheral-blood-progenitor-cell-mobilization-capability
#18
Alberto Ballestrero, Filippo Montemurro, Roberta Gonella, Antonio Capaldi, Marco Danova, Daniele Friedman, Maria Puglisi, Massimo Aglietta, Franco Patrone
We studied the safety, activity and peripheral blood progenitor cell mobilizing capability of a dose-dense combination of vinorelbine (VNB) and paclitaxel (PTX) as first-line chemotherapy for patients with metastatic breast cancer (MBC). Forty-three MBC patients were submitted to four cycles of VNB 30 mg/m2 and PTX 175 mg/m2 intravenously, every 2 weeks, as the first induction step of a tandem high-dose chemotherapy program. Granulocyte colony-stimulating factor (G-CSF) 5 microg/kg was administered daily from day +5 to +10 in order to accelerate hematopoietic recovery, or 48h after the last VNB-PTX when a leukapheresis was planned (after the third or fourth cycle)...
December 2003: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/12621490/mobilization-of-peripheral-blood-progenitor-cells-with-vinorelbine-and-granulocyte-colony-stimulating-factor-in-multiple-myeloma-patients-is-reliable-and-cost-effective
#19
MULTICENTER STUDY
M J Bargetzi, J Passweg, E Baertschi, A Schoenenberger, C Gwerder, A Tichelli, J Burger, W Mingrone, R Herrmann, A Gratwohl, M Wernli
Cyclophosphamide with granulocyte colony stimulating factor (G-CSF) is commonly used to mobilize stem cells in multiple myeloma. Timing of collection is variable and incidence and severity of side effects is substantial. To optimize timing of collection, to reduce side effects and to limit costs of the procedure, we evaluated vinorelbine, a drug shown to have activity in multiple myeloma, in combination with G-CSF as mobilizing regimen. A total of 19 consecutive patients with advanced stage multiple myeloma received one dose of vinorelbine 35 mg/m(2) intravenously on day 1 in an outpatient setting and G-CSF 10 microg/kg/day from day 4 divided in two daily doses...
January 2003: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/12050770/-role-of-iphosphamide-in-the-treatment-of-breast-cancer
#20
Magdolna Dank, Eva Pádi, Magdolna Csepreghy, Ernô Makó
Breast cancer is the most frequent solid tumor in women. Predictive and prognostic factors play an important role in the treatment of this cancer. We focused on high risk and heavily pre-treated metastatic breast cancer patients, trying to find the best combination of cytotoxic drugs with high efficacy and low toxicity. Ifosfamide is chemically related to nitrogen mustard and is a synthetic analogue of cyclophosphamide. Ifosfamide has a wide range of antitumor activity. Since ifosfamide as monotherapy has introduced significant tumor reduction in 1(st) line chemotherapy for advanced breast cancer, some studies started with high-dose continuous infusion of ifosfamide,or combined with paclitaxel or vinorelbine...
April 1, 2000: Magyar Onkologia
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