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Cycling power

Asmaa E Kassab, Ehab M Gedawy
As we are interested in synthetizing biologically active leads with dual anticancer and antibacterial activity, we adopted biology oriented drug synthesis (BIODS) strategy to synthesize a series of novel ciprofloxacin (CP) hybrids. The National Cancer Institute (USA) selected seventeen newly synthesized compounds for anticancer evaluation against 59 different human tumor cell lines. Five compounds 3e, 3f, 3h, 3o and 3p were further studied through determination of IC50 values against the most sensitive cancer cell lines...
March 9, 2018: European Journal of Medicinal Chemistry
Jules Gellaerts, Evgeny Bogdanov, Farzin Dadashi, Benoit Mariani
Ski Mountaineering (SkiMo) is a fast growing sport requiring both endurance and technical skills. It involves different types of locomotion with and without the skis. The aim of this study is to develop and validate in the snowfield a novel inertial-based system for analysing cycle parameters and classifying movement in SkiMo in real-time. The study was divided into two parts, one focused on real-time parameters estimation (cadence, distance from strides, stride duration, stride length, number of strides, slope gradient, and power) and, second, on transition detection (kickturns, skin on, skin off, ski on and off backpack) in order to classify between the different types of locomotion...
March 16, 2018: Sensors
Wan-Angkan Poolsri, Phornpun Phokrai, Somrudee Suwankulanan, Narinthorn Phakdeeto, Pattamaphorn Phunsomboon, Dumrongsak Pekthong, Lysiane Richert, Sutatip Pongcharoen, Piyarat Srisawang
Increased expression levels of both mitochondrial citrate transporter (CTP) and plasma membrane citrate transporter (PMCT) proteins have been found in various cancers. The transported citrates by these two transporter proteins provide acetyl-CoA precursors for the de novo lipogenesis (DNL) pathway to support a high rate of cancer cell viability and development. Inhibition of the DNL pathway promotes cancer cell apoptosis without apparent cytotoxic to normal cells, leading to the representation of selective and powerful targets for cancer therapy...
2018: BioMed Research International
Doodipala Samba Reddy
Neurosteroids like allopregnanolone (AP) are positive allosteric modulators of synaptic and extrasynaptic GABA-A receptors. AP and related neurosteroids exhibit a greater potency for δ-containing extrasynaptic receptors. The δGABA-A receptors, which are expressed extrasynaptically in the dentate gyrus and other regions, contribute to tonic inhibition, promoting network shunting as well as reducing seizure susceptibility. Levels of endogenous neurosteroids fluctuate with ovarian cycle. Natural and synthetic neurosteroids maximally potentiate tonic inhibition in the hippocampus and provide robust protection against a variety of limbic seizures and status epilepticus...
2018: Vitamins and Hormones
Harsh H Buddhadev, Daniel L Crisafulli, David N Suprak, Jun G San Juan
Cycling is commonly prescribed for physical rehabilitation of individuals with knee osteoarthritis (OA). Despite the known therapeutic benefits, no research has examined interlimb symmetry of power output during cycling in these individuals. We investigated the effects of external workload and cadence on interlimb symmetry of crank power output in individuals with knee OA versus healthy controls. Twelve older participants with knee OA and 12 healthy sex- and age-matched controls were recruited. Participants performed 2-minute bouts of stationary cycling at four workload-cadence conditions (75 W-60 rpm, 75 W-90 rpm, 100 W-60 rpm, and 100 W-90 rpm)...
March 15, 2018: Journal of Applied Biomechanics
Duong Tung Pham, Joseph Paul Baboo, Jinju Song, Sungjin Kim, Jeonggeun Jo, Vinod Mathew, Muhammad Hilmy Alfaruqi, Balaji Sambandam, Jaekook Kim
Pyrite (FeS2 ) is a promising electrode material for lithium ion batteries (LIBs) because of its high natural availability, low toxicity, cost-effectiveness, high theoretical capacity (894 mA h g-1 ) and high theoretical specific energy density (1270 W h kg-1 , 4e- /FeS2 ). Nevertheless, the use of FeS2 in electrochemical capacitors was restricted due to fast capacity fading as a result of polysulfide (S/Sn 2- ) formation during the initial electrochemical cycling. In order to avoid the formation of polysulfides, we employed the strategy of utilizing an ether based electrolyte (1...
March 15, 2018: Nanoscale
Shoushuang Huang, Haitao Wang, Shangdai Wang, Zhangjun Hu, Ling Zhou, Zhiwen Chen, Yong Jiang, Xuefeng Qian
Designing low-cost electrocatalysts combining the features of outstanding catalytic activity, excellent electrical conductivity, and high chemical stability remains a critical challenge for the large-scale fabrication of dye-sensitized solar cells (DSSCs). Here we report the controlled synthesis of CoS2 -CoSe2 heterostructured nanocrystals encapsulated in N-doped carbon hollow nanocubes (CoS2 -CoSe2 @NC) through simultaneous sulfurization and selenization of polydopamine coated Prussian blue analogs. Benefiting from both structural and compositional characteristics, namely, the synergistic effect of CoS2 -CoSe2 heterojunctions, the conductive N-doped carbon coating and the porous structure of the nanocubes, the resultant CoS2 -CoSe2 @NC nanocubes exhibit excellent electrocatalytic activity and cycling stability toward the generation of I3 - ions in DSSCs...
March 15, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
Marlene J Schulte, Jody L Clasey, Bradley S Fleenor, Haley C Bergstrom
There are conflicting suggestions regarding the most valid resistance (3-5% of body weight) to use for the critical power (CP) 3-min all-out (CP3min ) test to estimate CP and anaerobic work capacity (AWC). The purpose of this study was to determine if the CP and AWC estimates from the CP3min test were affected by the percentage of body weight used to set the resistance on a Monark cycle ergometer. Ten recreationally trained participants (mean ± SD: Age: 22.2 ± 2.2 yrs.) completed the CP3min test at resistances of 4...
2018: International Journal of Exercise Science
Boe M Burrus, Brian M Moscicki, Tracey D Matthews, Vincent J Paolone
Chronic supplementation of L-carnitine and carbohydrate has been reported to increase L-carnitine content in skeletal muscle and have positive influences on exercise variables and performance. This study investigated the acute intake of L-carnitine and carbohydrate on the exercise parameters of cycling. A total of 10 males (27.0 ± 4 years) completed two exercise sessions consisting of 40 min of cycling at 65% of VO2peak , followed by cycling to exhaustion at 85% of VO2peak . L-carnitine or a placebo was consumed 3 hours prior to exercise, and beverages consisting of 94 g of carbohydrate were consumed at both 2 hours, and 30 minutes prior to exercise...
2018: International Journal of Exercise Science
Leandro C Felippe, Guilherme A Ferreira, Fernando De-Oliveira, Flavio O Pires, Adriano E Lima-Silva
Objective: The purpose of this study was to investigate the difference between arterialized and venous blood lactate concentrations [La] during constant-load exercises at different intensities. Methods: Fifteen physically active men cycled for 30 minutes (or until exhaustion) at the first lactate threshold (LT1 ), at 50% of the difference between the first and second lactate threshold (TT50% ), at the second lactate threshold (LT2 ), and at 25% of the difference between LT2 and maximal aerobic power output (TW25% )...
June 2017: Journal of Exercise Science and Fitness
Fengmei Ban, Andy Baker, Christopher E Marjo, Wuhui Duan, Xianglei Li, Jinxian Han, Katie Coleborn, Rabeya Akter, Ming Tan, Gurinder Nagra
Stalagmites play an important role in paleoclimatic reconstructions from seasonal to orbital time scales as230 Th-dating can provide an accurate absolute age. Additionally, seasonal trace element and optical layers can provide a precise age. We analyzed the seasonal variability of multiple trace elements on a stalagmite (XMG) in Shihua Cave, Beijing and compared them with results from laminae counting. The results show that (1) the polished section of the topmost part of XMG has obvious bi-optical layers under a conventional transmission microscope, however, laminae are not observed using this method in the rest of the sample, and (2) The variations of P/Ca, Sr/Ca, Ba/Ca, U/Ca and Mg/Ca show seasonal cycles throughout the sample...
March 14, 2018: Scientific Reports
Bernadette M Glasheen, Seemanti Ramanath, Monica Patel, Debra Sheppard, Joy T Puthawala, Lauren A Riley, Douglas M Swank
Muscles have evolved to power a wide variety of movements. A protein component critical to varying power generation is the myosin isoform present in the muscle. However, how functional variation in muscle arises from myosin structure is not well understood. We studied the influence of the converter, a myosin structural region at the junction of the lever arm and catalytic domain, using Drosophila because its single myosin heavy chain gene expresses five alternative converter versions (11a-e). We created five transgenic fly lines, each forced to express one of the converter versions in their indirect flight muscle (IFM) fibers...
March 13, 2018: Biophysical Journal
Xuefeng Guo, Chao Yu, Zhouyang Yin, Shouheng Sun, Christopher Takakazu Seto
We report a Ni30Pd70/nitrogen-doped graphene (NG) catalyst that hydrodehalogenates halogenated aromatics under mild reaction conditions. It reduces mono- or dichloroarenes to the corresponding dehalogenated arenes in >90% yield in 10% aqueous isopropanol solvent at or below 50C within 5 hours. Tests on a variety of substrates containing various functional groups show that the catalyst is selective for reduction of C-Cl and C-Br bonds. In addition, this catalyst completely hydrodehalogenates high concentration solutions of dioxin, polychlorinated biphenyls (PCBs), chloroaromatic constituents of the defoliant agent orange, and polybrominated diphenyl ethers (PBDEs) in 12 hours...
March 14, 2018: ChemSusChem
Juan M Murias, Silvia Pogliaghi, Donald H Paterson
The accuracy of an exhaustive ramp incremental (RI) test to determine maximal oxygen uptake ([Formula: see text]O2max ) was recently questioned and the utilization of a verification phase proposed as a gold standard. This study compared the oxygen uptake ([Formula: see text]O2 ) during a RI test to that obtained during a verification phase aimed to confirm attainment of [Formula: see text]O2max . Sixty-one healthy males [31 older (O) 65 ± 5 yrs; 30 younger (Y) 25 ± 4 yrs] performed a RI test (15-20 W/min for O and 25 W/min for Y)...
2018: Frontiers in Physiology
Thomas Stöggl, Boye Welde, Matej Supej, Chiara Zoppirolli, Carsten G Rolland, Hans-Christer Holmberg, Barbara Pellegrini
Here, female and male elite cross-country (XC) skiers were compared on varying terrain during an official 10-km (women) and 15-km (men) Norwegian championship race. On the basis of race performance, 82 skiers were classified as fast (FS) (20 women, 20 men) or slower (SS) (21, 21) skiers. All were video recorded on flat (0°), intermediate (3.5°), uphill (7.1°) and steep uphill (11°) terrain during the race at a distance of 0.8, 1.2, 2.1 and 7.1 km from the start, respectively. All skiers employed exclusively double-poling (DP) on the flat section and, except for the male winner, exclusively diagonal stride (DIA) on the uphill sections...
March 2018: Journal of Sports Science & Medicine
Lydia K Caldwell, William H DuPont, Matthew K Beeler, Emily M Post, Emily C Barnhart, Vincent H Hardesty, John P Anders, Emily C Borden, Jeff S Volek, William J Kraemer
The purpose of this double-blind, placebo-controlled investigation was to examine the effects of a Korean Ginseng (GINST15) on measures of perception and physical performance following an acute bout of resistance exercise. Ten women (age: 38.7 ± 7.8 years; height: 1.64 ± 0.05 m; body mass: 76.0 ± 11.6 kg) and nine men (age: 41.2. ± 9.7 years; height: 1.77 ± 0.05 m; body mass: 88.5 ± 5.0 kg) completed the investigation. Participants were randomized to a three-cycle testing scheme consisting of high dose ginseng (HIGH: 960 mg/day), low dose ginseng (LOW: 160 mg/day) and placebo (PBO: 0 mg/day)...
March 2018: Journal of Sports Science & Medicine
Elvera Overdevest, Jeroen A Wouters, Kevin H M Wolfs, Job J M van Leeuwen, Sam Possemiers
Previous studies have shown that polyphenol supplementation may be an effective strategy to improve exercise performance, due to their antioxidant character and ability to stimulate NO production. These properties may contribute to exercise performance, yet no conclusive research has been performed in exploring the direct effects of citrus flavonoids on human exercise performance. Therefore, the purpose of this study was to assess whether supplementation of a customized citrus flavonoid (CF) extract for 4 weeks improves cycling time-trial performance in trained male athletes...
March 2018: Journal of Sports Science & Medicine
Flávio O Pires, Cayque Brietzke, Fabiano A Pinheiro, Katherine Veras, Eugênia C T de Mattos, André L F Rodacki, Carlos Ugrinowitsch
We investigated if a carbohydrate (CHO) mouth rinse may attenuate global fatigue and improve 4-km cycling time trial (TT4km ) performance. After a preliminary session, cyclists ( n = 9) performed a TT4km after a CHO or placebo (PLA) mouth rinse. Mean power output, time, and ratings of perceived exertion (RPE) were recorded throughout the TT4km . Twitch interpolation responses (%VA; voluntary activation and ∆Tw; delta peak twitch torque) were compared pre and post TT4km with traditional statistics and effect size (ES) analysis...
March 12, 2018: Nutrients
Sultana Mehbuba Hossain, Ezharul Hoque Chowdhury
Biodegradable inorganic apatite-based particle complex is popular for its pH-sensitivity at the endosomal acidic environment to facilitate drug release following cellular uptake. Despite being a powerful anticancer drug, doxorubicin shows severe off-target effects and therefore would need a carrier for the highest effectiveness. We aimed to chemically modify carbonate apatite (CA) with Krebs cycle intermediates, such as citrate and succinate in order to control the growth of the resultant particles to more efficiently carry and transport the anticancer drug into the cancer cells...
March 11, 2018: Pharmaceutics
Hongcai Gao, Leigang Xue, Sen Xin, John B Goodenough
A safe potassium rechargeable battery of high energy density and excellent cycling stability is demonstrated. The cell contained a polyaniline cathode into which the anion component of the electrolyte salt is inserted on charge, extracted on discharge; but the K+ ion of a KPF6 salt is plated/stripped on the potassium-metal anode. The use of a p-type polymer cathode increases the cell voltage. By replacing the organic-liquid electrolyte in a glass-fiber separator by a polymer-gel electrolyte of cross-linked poly(methyl methacrylate), a dendrite-free potassium anode can be plated/stripped and the electrode/electrolyte interface stabilized...
March 13, 2018: Angewandte Chemie
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