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https://www.readbyqxmd.com/read/27912776/improving-stroke-prevention-therapy-for-patients-with-atrial-fibrillation-in-primary-care-protocol-for-a-pragmatic-cluster-randomized-trial
#1
Theresa M Lee, Noah M Ivers, Sacha Bhatia, Debra A Butt, Paul Dorian, Liisa Jaakkimainen, Kori Leblanc, Dan Legge, Dante Morra, Alissia Valentinis, Laura Wing, Jacqueline Young, Karen Tu
BACKGROUND: The prevalence of atrial fibrillation (AF) is growing as the population ages, and at least 15% of ischemic strokes are attributed to AF. However, many high-risk AF patients are not offered guideline-recommended stroke prevention therapy due to a variety of system, provider, and patient-level barriers. METHODS: We will conduct a pragmatic, cluster-randomized controlled trial randomizing primary care clinics to test a "toolkit" of quality improvement interventions in primary care...
December 3, 2016: Implementation Science: IS
https://www.readbyqxmd.com/read/27910600/development-of-a-neural-network-technique-for-kstar-thomson-scattering-diagnostics
#2
Seung Hun Lee, J H Lee, I Yamada, Jae Sun Park
Neural networks provide powerful approaches of dealing with nonlinear data and have been successfully applied to fusion plasma diagnostics and control systems. Controlling tokamak plasmas in real time is essential to measure the plasma parameters in situ. However, the χ(2) method traditionally used in Thomson scattering diagnostics hampers real-time measurement due to the complexity of the calculations involved. In this study, we applied a neural network approach to Thomson scattering diagnostics in order to calculate the electron temperature, comparing the results to those obtained with the χ(2) method...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27908713/optimization-of-resistant-starch-formation-from-high-amylose-corn-starch-by-microwave-irradiation-treatments-and-characterization-of-starch-preparations
#3
Selime Mutlu, Kevser Kahraman, Serpil Öztürk
The effects of microwave irradiation on resistant starch (RS) formation and functional properties in high-amylose corn starch, Hylon VII, by applying microwave-storing cycles and drying processes were investigated. The Response Surface Methodology (RSM) was used to optimize the reaction conditions, microwave time (2-4min) and power (20-100%), for RS formation. The starch:water (1:10) mixtures were cooked and autoclaved and then different microwave-storing cycles and drying (oven or freeze drying) processes were applied...
November 28, 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27908704/on-the-relationship-between-cell-cycle-analysis-with-ergodic-principles-and-age-structured-cell-population-models
#4
K Kuritz, D Stöhr, N Pollak, F Allgöwer
Cyclic processes, in particular the cell cycle, are of great importance in cell biology. Continued improvement in cell population analysis methods like fluorescence microscopy, flow cytometry, CyTOF or single-cell omics made mathematical methods based on ergodic principles a powerful tool in studying these processes. In this paper, we establish the relationship between cell cycle analysis with ergodic principles and age structured population models. To this end, we describe the progression of a single cell through the cell cycle by a stochastic differential equation on a one dimensional manifold in the high dimensional dataspace of cell cycle markers...
November 28, 2016: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/27906408/spatially-uniform-resistance-switching-of-low-current-high-endurance-titanium-niobium-oxide-memristors
#5
Suhas Kumar, Noraica Davila, Ziwen Wang, Xiaopeng Huang, John Paul Strachan, David Vine, A L David Kilcoyne, Yoshio Nishi, R Stanley Williams
We analyzed micrometer-scale titanium-niobium-oxide prototype memristors, which exhibited low write-power (<3 μW) and energy (<200 fJ per bit per μm(2)), low read-power (∼nW), and high endurance (>millions of cycles). To understand their physico-chemical operating mechanisms, we performed in operando synchrotron X-ray transmission nanoscale spectromicroscopy using an ultra-sensitive time-multiplexed technique. We observed only spatially uniform material changes during cell operation, in sharp contrast to the frequently detected formation of a localized conduction channel in transition-metal-oxide memristors...
December 1, 2016: Nanoscale
https://www.readbyqxmd.com/read/27906390/flexible-all-solid-state-supercapacitors-based-on-polyaniline-orderly-nanotubes-array
#6
Huihua Li, Juan Song, Linlin Wang, Xiaomiao Feng, Ruiqing Liu, Wenjin Zeng, Zhendong Huang, Yanwen Ma, Lianhui Wang
Flexible all-solid-state supercapacitors are crucial to meet the growing needs for portable electronic devices such as foldable phones and wearable electronics. As promising candidates for pseudocapacitor electrode materials, polyaniline (PANI) orderly nanotube arrays are prepared via a simple template electrodeposition method. The structures of the final product were characterized using various characterization techniques, including scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FT-IR), and X-ray photoelectron spectroscopy (XPS)...
December 1, 2016: Nanoscale
https://www.readbyqxmd.com/read/27905613/unambiguous-identification-and-discovery-of-bacterial-siderophores-by-direct-injection-21-tesla-fourier-transform-ion-cyclotron-resonance-mass-spectrometry
#7
Lawrence R Walker, Malak M Tfaily, Jared B Shaw, Nancy J Hess, Ljiljana Paša-Tolić, David W Koppenaal
Under iron-limiting conditions, bacteria produce low molecular mass Fe(iii) binding molecules known as siderophores to sequester the Fe(iii), along with other elements, increasing their bioavailability. Siderophores are thought to influence iron cycling and biogeochemistry in both marine and terrestrial ecosystems and hence the need for rapid, confident characterization of these compounds has increased. In this study, the type of siderophores produced by two marine bacterial species, Synechococcus sp. PCC 7002 and Vibrio cyclitrophicus 1F53, were characterized by use of a newly developed 21 T Fourier Transform Ion Cyclotron Resonance Mass Spectrometer (FTICR MS) with direct injection electrospray ionization...
December 1, 2016: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/27901192/evaluation-of-the-complexity-and-performance-of-marine-planktonic-trophic-models
#8
Suzana G Leles, Jean L Valentin, Gisela M Figueiredo
Planktonic models represent a powerful tool for creating hypotheses and making predictions about the functioning of marine ecosystems. Their complexity varies according to the number of state variables and the choice of functional forms. We evaluated plankton models during the last 15 years (n =145) with the aims of understanding why they differ in complexity, evaluating model robustness, and describing studies of plankton modelling around the globe. We classified models into four groups: Nutrient-Phytoplankton-Zooplankton (NPZ), Nutrient-Phytoplankton-Zooplankton-Detritus (NPZD), Size-Structured (SS) and Plankton-Functional-Type (PFT)...
2016: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/27900694/methods-for-the-isolation-of-genes-encoding-novel-pha-metabolism-enzymes-from-complex-microbial-communities
#9
Jiujun Cheng, Ricardo Nordeste, Maria A Trainer, Trevor C Charles
Development of different PHAs as alternatives to petrochemically derived plastics can be facilitated by mining metagenomic libraries for diverse PHA cycle genes that might be useful for synthesis of bio-plastics. The specific phenotypes associated with mutations of the PHA synthesis pathway genes in Sinorhizobium meliloti and Pseudomonas putida, allows the use of powerful selection and screening tools to identify complementing novel PHA synthesis genes. Identification of novel genes through their function rather than sequence facilitates the functional proteins that may otherwise have been excluded through sequence-only screening methodology...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27898762/an-expanded-maize-gene-expression-atlas-based-on-rna-sequencing-and-its-use-to-explore-root-development
#10
Scott C Stelpflug, Rajandeep S Sekhon, Brieanne Vaillancourt, Candice N Hirsch, C Robin Buell, Natalia de Leon, Shawn M Kaeppler
Comprehensive and systematic transcriptome profiling provides valuable insight into biological and developmental processes that occur throughout the life cycle of a plant. We have enhanced our previously published microarray-based gene atlas of maize ( L.) inbred B73 to now include 79 distinct replicated samples that have been interrogated using RNA sequencing (RNA-seq). The current version of the atlas includes 50 original array-based gene atlas samples, a time-course of 12 stalk and leaf samples postflowering, and an additional set of 17 samples from the maize seedling and adult root system...
March 2016: Plant Genome
https://www.readbyqxmd.com/read/27898641/oral-contraceptive-use-dampens-physiological-adaptations-to-sprint-interval-training
#11
Mia A Schaumberg, David G Jenkins, Xanne A K Janse de Jonge, Lynne M Emmerton, Tina L Skinner
PURPOSE: Oral contraceptive (OC) use reduces peak aerobic capacity (V˙O2peak), however, whether it also influences adaptations to training has yet to be determined. This study aimed to examine the influence of OC use on peak performance [peak power output (PPO)] and physiological adaptations [V˙O2peak and peak cardiac output (Q˙peak)] following sprint interval training (SIT) in recreationally-active women. METHODS: Women taking an OC (n=25) or experiencing natural regular menstrual cycles (MC; n=16) completed an incremental exercise test to assess V˙O2peak, PPO, and Q˙peak before, immediately after, and four weeks following 12 sessions of SIT...
November 28, 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27897989/periodization-of-carbohydrate-intake-short-term-effect-on-performance
#12
Laurie-Anne Marquet, Christophe Hausswirth, Odeline Molle, John A Hawley, Louise M Burke, Eve Tiollier, Jeanick Brisswalter
BACKGROUND: "Sleep-low" consists of a sequential periodization of carbohydrate (CHO) availability-low glycogen recovery after "train high" glycogen-depleting interval training, followed by an overnight-fast and light intensity training ("train low") the following day. This strategy leads to an upregulation of several exercise-responsive signaling proteins, but the chronic effect on performance has received less attention. We investigated the effects of short-term exposure to this strategy on endurance performance...
November 25, 2016: Nutrients
https://www.readbyqxmd.com/read/27896682/methods-of-power-force-velocity-profiling-during-sprint-running-a-narrative-review
#13
REVIEW
Matt R Cross, Matt Brughelli, Pierre Samozino, Jean-Benoit Morin
The ability of the human body to generate maximal power is linked to a host of performance outcomes and sporting success. Power-force-velocity relationships characterize limits of the neuromuscular system to produce power, and their measurement has been a common topic in research for the past century. Unfortunately, the narrative of the available literature is complex, with development occurring across a variety of methods and technology. This review focuses on the different equipment and methods used to determine mechanical characteristics of maximal exertion human sprinting...
November 28, 2016: Sports Medicine
https://www.readbyqxmd.com/read/27893190/a-high-performance-lithium-ion-capacitor-based-on-2d-nanosheet-materials
#14
Shaohui Li, Jingwei Chen, Mengqi Cui, Guofa Cai, Jiangxin Wang, Peng Cui, Xuefei Gong, Pooi See Lee
Lithium-ion capacitors (LICs) are promising electrical energy storage systems for mid-to-large-scale applications due to the high energy and large power output without sacrificing long cycle stability. However, due to the different energy storage mechanisms between anode and cathode, the energy densities of LICs often degrade noticeably at high power density, because of the sluggish kinetics limitation at the battery-type anode side. Herein, a high-performance LIC by well-defined ZnMn2 O4 -graphene hybrid nanosheets anode and N-doped carbon nanosheets cathode is presented...
November 28, 2016: Small
https://www.readbyqxmd.com/read/27892964/temporally-coherent-terawatt-attosecond-xfel-synchronized-with-a-few-cycle-laser
#15
Sandeep Kumar, Yong Woon Parc, Alexandra S Landsman, Dong Eon Kim
Attosecond metrology using laser-based high-order harmonics has been significantly advanced and applied to various studies of electron dynamics in atoms, molecules and solids. Laser-based high-order harmonics have a limitation of low power and photon energies. There is, however, a great demand for even higher power and photon energy. Here, we propose a scheme for a terawatt attosecond (TW-as) X-ray pulse in X-ray free-electron laser controlled by a few cycle IR pulse, where one dominant current spike in an electron bunch is used repeatedly to amplify a seeded radiation to a terawatt level...
November 28, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27889617/aquatic-viral-metagenomics-lights-and-shadows
#16
REVIEW
Alberto Rastrojo, Antonio Alcamí
Viruses are the most abundant biological entities on Earth, exceeding bacteria in most of the ecosystems. Specially in oceans, viruses are thought to be the major planktonic predators shaping microorganism communities and controlling ocean biological capacity. Plankton lysis by viruses plays an important role in ocean nutrient and energy cycles. Viral metagenomics has emerged as a powerful tool to uncover viral diversity in aquatic ecosystems through the use of Next Generation Sequencing. However, many of the commonly used viral sample preparation steps have several important biases that must be considered to avoid a misinterpretation of the results...
November 23, 2016: Virus Research
https://www.readbyqxmd.com/read/27889272/can-muscle-coordination-explain-the-advantage-of-using-the-standing-position-during-intense-cycling
#17
Nicolas A Turpin, Antony Costes, Pierre Moretto, Bruno Watier
OBJECTIVES: When compared to seated, the standing position allows the production of higher power outputs during intense cycling. We hypothesized that muscle coordination could explain this advantage. To test this hypothesis, we assessed muscle activity over a wide range of power outputs for both seated and standing cycling positions. DESIGN: Nine lower limb muscle activities from seventeen untrained volunteers were recorded during cycling sequences performed in the seated and the standing positions at power outputs ranging from ∼100 to 700W at 90±5 revolutions-per-minute (RPM)...
November 17, 2016: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/27888217/quantitative-fastfucci-assay-defines-cell-cycle-dynamics-at-single-cell-level
#18
Siang-Boon Koh, Patrice Mascalchi, Esther Rodriguez, Yao Lin, Duncan I Jodrell, Frances M Richards, Scott K Lyons
The fluorescence ubiquitination-based cell cycle indicator (FUCCI) is a powerful tool for use in live cells but current FUCCI-based assays have limited throughput and quantitative robustness. Here, we developed a lentiviral system that rapidly introduced FUCCI transgenes into cells, using an all-in-one expression cassette FastFUCCI. The approach obviated the need for sequential transduction and characterisation, improving labelling efficiency. We coupled the system to an automated imaging workflow capable of handling large datasets...
November 25, 2016: Journal of Cell Science
https://www.readbyqxmd.com/read/27886606/a-symmetric-supercapacitor-biofuel-cell-hybrid-device-based-on-enzyme-modified-nanoporous-gold-an-autonomous-pulse-generator
#19
Xinxin Xiao, Peter Ó Conghaile, Dónal Leech, Roland Ludwig, Edmond Magner
The integration of supercapacitors with enzymatic biofuel cells (BFCs) can be used to prepare hybrid devices in order to harvest significantly higher power output. In this study, a supercapacitor/biofuel cell hybrid device was prepared by the immobilisation of redox enzymes with electrodeposited poly(3,4-ethylenedioxythiophene) (PEDOT) and the redox polymer [Os(2,2'-bipyridine)2(polyvinylimidazole)10Cl](+/2+)(Os(bpy)2PVI) on dealloyed nanoporous gold. The thickness of the deposition layer can be easily controlled by tuning the deposition conditions...
November 9, 2016: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27885371/hierarchical-ternary-ni-co-se-nanowires-for-high-performance-supercapacitor-device-design
#20
Kailu Guo, Shizhong Cui, Hongwei Hou, Weihua Chen, Liwei Mi
Large-scale uniform Ni-Co-Se bimetallic ternary nanowires have been successfully synthesized through a successive cation exchange. First, NiSe nanowires in situ grown on nickel foam (NF) were prepared by a facile solvothermal route. Next, a series of ternary materials possessing different proportions of Ni and Co were fabricated by a Co-exchange method using the Ni@NiSe material as a template, which effectively achieved morphological inheritance from the parent material. To explore the electrochemical performance, all synthetic materials were assembled into asymmetric supercapacitor devices...
November 25, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
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