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https://www.readbyqxmd.com/read/28538683/metabolic-investigations-of-the-molecular-mechanisms-associated-with-parkinson-s-disease
#1
REVIEW
Robert Powers, Shulei Lei, Annadurai Anandhan, Darrell D Marshall, Bradley Worley, Ronald L Cerny, Eric D Dodds, Yuting Huang, Mihalis I Panayiotidis, Aglaia Pappa, Rodrigo Franco
Parkinson's disease (PD) is a neurodegenerative disorder characterized by fibrillar cytoplasmic aggregates of α-synuclein (i.e., Lewy bodies) and the associated loss of dopaminergic cells in the substantia nigra. Mutations in genes such as α-synuclein (SNCA) account for only 10% of PD occurrences. Exposure to environmental toxicants including pesticides and metals (e.g., paraquat (PQ) and manganese (Mn)) is also recognized as an important PD risk factor. Thus, aging, genetic alterations, and environmental factors all contribute to the etiology of PD...
May 24, 2017: Metabolites
https://www.readbyqxmd.com/read/28538327/quantifying-the-effect-of-carbohydrate-mouth-rinsing-on-exercise-performance
#2
Daniel J Peart
Peart, DJ. Quantifying the effect of carbohydrate mouth rinsing on exercise performance. J Strength Cond Res 31(6): 1737-1743, 2017-The purpose of this study was to review the existing literature investigating carbohydrate mouth rinsing as an ergogenic aid using the effect sizes (ES) and percentage change in performance of the respective studies as outcome measures. A trivial-small average overall ES was present for the 25 studies included in the review (0.18, 95% confidence interval [CI] = 0.10-0.27). Effect sizes for the subgroups were ≥25 minutes (0...
June 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28538317/effects-of-inertial-setting-on-power-force-work-and-eccentric-overload-during-flywheel-resistance-exercise-in-women-and-men
#3
Luis M Martinez-Aranda, Rodrigo Fernandez-Gonzalo
Martinez-Aranda, LM and Fernandez-Gonzalo, R. Effects of inertial setting on power, force, work and eccentric overload during flywheel resistance exercise in women and men. J Strength Cond Res 31(6): 1653-1661, 2017-Exercise load is a key component in determining end-point adaptations to resistance exercise. Yet, there is no information regarding the use of different inertia (i.e., loads) during isoinertial flywheel resistance exercise, a very popular high-intensity training model. Thus, this study examined power, work, force, and eccentric overload produced during flywheel resistance exercise with different inertial settings in men and women...
June 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28538055/high-reliability-principles-must-be-tied-to-value-based-outcomes
#4
Mitchell L Wasden
WellStar Health System and the Medical University of South Carolina (MUSC), highlighted in this issue's feature articles, are two organizations seeking to drive high reliability by educating leaders and incorporating high-reliability principles into their quality improvement (QI) efforts. The organizations have taken slightly different approaches to executing on high reliability, yet both are encouraged by the apparent success of high-reliability principles in other industries.The high-reliability framework is often applied to healthcare despite the limitations of comparing healthcare organizations to nuclear reactors, commercial airlines, and aircraft carriers...
July 2017: Frontiers of Health Services Management
https://www.readbyqxmd.com/read/28537741/an-optimized-extraction-method-to-remove-humic-acids-interferences-from-soil-samples-prior-to-microbial-proteome-measurements
#5
Chen Qian, Robert L Hettich
The microbial composition and their activities in soil environments play a critical role in organic matter transformation and nutrient cycling. Liquid chromatography coupled to high performance mass spectrometry provides a powerful approach to characterize soil microbiomes; however, the limited microbial biomass and the presence of abundant interferences in soil samples present major challenges to proteome extraction and subsequent MS measurement. To this end, we have designed an experimental method to improve microbial proteome measurement by removing the soil-borne humic substances co-extraction from soils...
May 24, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28535344/clarifying-the-controversial-catalytic-performance-of-co-oh-2-and-co3o4-for-oxygen-reduction-evolution-reactions-toward-efficient-zn-air-batteries
#6
Zhishuang Song, Xiaopeng Han, Yida Deng, Naiqin Zhao, Wenbin Hu, Cheng Zhong
Cobalt-based nanomaterials have been widely studied as catalysts for the oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) due to their remarkable bifunctional catalytic activity, low cost and easy available. However, controversial results concerning OER/ORR performance exist between different types of cobalt-based catalysts, especially for Co(OH)2 and Co3O4. To address this issue, we develop a facile electrochemical deposition method to grow Co(OH)2 directly on the skeleton of carbon cloth, and further Co3O4 was obtained by post thermal treatment...
May 23, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28534826/atp-driven-contraction-of-phage-t3-capsids-with-dna-incompletely-packaged-in-vivo
#7
Philip Serwer, Elena T Wright
Adenosine triphosphate (ATP) cleavage powers packaging of a double-stranded DNA (dsDNA) molecule in a pre-assembled capsid of phages that include T3. Several observations constitute a challenge to the conventional view that the shell of the capsid is energetically inert during packaging. Here, we test this challenge by analyzing the in vitro effects of ATP on the shells of capsids generated by DNA packaging in vivo. These capsids retain incompletely packaged DNA (ipDNA) and are called ipDNA-capsids; the ipDNA-capsids are assumed to be products of premature genome maturation-cleavage...
May 19, 2017: Viruses
https://www.readbyqxmd.com/read/28534816/roi-based-on-board-compression-for-hyperspectral-remote-sensing-images-on-gpu
#8
Rossella Giordano, Pietro Guccione
In recent years, hyperspectral sensors for Earth remote sensing have become very popular. Such systems are able to provide the user with images having both spectral and spatial information. The current hyperspectral spaceborne sensors are able to capture large areas with increased spatial and spectral resolution. For this reason, the volume of acquired data needs to be reduced on board in order to avoid a low orbital duty cycle due to limited storage space. Recently, literature has focused the attention on efficient ways for on-board data compression...
May 19, 2017: Sensors
https://www.readbyqxmd.com/read/28533889/effects-of-low-dose-acetazolamide-on-exercise-performance-in-simulated-altitude
#9
Ernst Elisabeth, Gatterer Hannes, Burtscher Johannes, Faulhaber Martin, Pocecco Elena, Burtscher Martin
Preventive effects of acetazolamide (ACZ) on acute mountain sickness (AMS) are well established but effects on exercise performance at high altitude or in hypoxia have been less considered and are still inconsistent. We hypothesized that low-dose ACZ would not impair exercise performance at simulated high altitude. Thus, the aim of this study was to evaluate the interaction between low-dose ACZ and exercise performance in normobaric hypoxia. Sixteen subjects (8 males and 8 females) were randomly assigned either to receive low-dose ACZ (3×125 mg in 36 hours) or placebo...
2017: International Journal of Physiology, Pathophysiology and Pharmacology
https://www.readbyqxmd.com/read/28531964/non-electron-transfer-chain-mitochondrial-defects-differently-regulate-hif-1%C3%AE-degradation-and-transcription
#10
Antonina N Shvetsova, Daniela Mennerich, Juha M Kerätär, J Kalervo Hiltunen, Thomas Kietzmann
Mitochondria are the main consumers of molecular O2 in a cell as well as an abundant source of reactive oxygen species (ROS). Both, molecular oxygen and ROS are powerful regulators of the hypoxia-inducible factor-1α-subunit (HIF-α). While a number of mechanisms in the oxygen-dependent HIF-α regulation are quite well known, the view with respect to mitochondria is less clear. Several approaches using pharmacological or genetic tools targeting the mitochondrial electron transport chain (ETC) indicated that ROS, mainly formed at the Rieske cluster of complex III of the ETC, are drivers of HIF-1α activation...
May 8, 2017: Redox Biology
https://www.readbyqxmd.com/read/28531567/impact-of-body-composition-parameters-on-clinical-outcomes-in-patients-with-metastatic-castrate-resistant-prostate-cancer-treated-with-docetaxel
#11
Samantha J Cushen, Derek G Power, Kevin P Murphy, Ray McDermott, Brendan T Griffin, Marvin Lim, Louise Daly, Peter MacEneaney, Kathleen O' Sullivan, Carla M Prado, Aoife M Ryan
BACKGROUND: Body composition may influence clinical outcomes of certain chemotherapeutic agents. We examined the prognostic significance of skeletal muscle mass and adipose tissue on docetaxel toxicity and overall survival in patients with metastatic castrate resistant prostate cancer (mCRPC). METHODS: A retrospective review of patients medical records with mCRPC, treated with docetaxel was conducted. Body composition parameters (skeletal muscle mass, muscle attenuation [MA], visceral and subcutaneous adipose tissue) were measured at L3 by computed tomography (CT) and defined using previously established cut points...
June 2016: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/28530803/red-phosphorus-nano-dots-on-reduced-graphene-oxide-as-a-flexible-and-ultra-fast-anode-for-sodium-ion-batteries
#12
Yihang Liu, Anyi Zhang, Chenfei Shen, Qingzhou Liu, Xuan Cao, Yuqiang Ma, Liang Chen, Christian Lau, Tian-Chi Chen, Fei Wei, Chongwu Zhou
Sodium-ion batteries offer an attractive option for potential low cost and large scale energy storage due to the earth abundance of sodium. Red phosphorus is considered as a high capacity anode for sodium-ion batteries with a theoretical capacity of 2596 mAh/g. However, similar to silicon in lithium-ion batteries, several limitations such as large volume expansion upon sodiation/de-sodiation and low electronic conductance have severely limited the performance of red phosphorus anodes. In order to address the above challenges, we have developed a method to deposit red phosphorus nano-dots densely and uniformly onto reduced graphene oxide sheets (P@RGO) to minimize the sodium ion diffusion length and the sodiation/de-sodiation stresses, and the RGO network also serves as electron pathway and creates free space to accommodate the volume variation of phosphorus particles...
May 22, 2017: ACS Nano
https://www.readbyqxmd.com/read/28530505/ingestion-of-sodium-bicarbonate-nahco3-following-a-fatiguing-bout-of-exercise-accelerates-post-exercise-acid-base-balance-recovery-and-improves-subsequent-high-intensity-cycling-time-to-exhaustion
#13
Lewis A Gough, Steven Rimmer, Callum J Osler, Matthew F Higgins
This study evaluated the ingestion of sodium bicarbonate (NaHCO3) on post-exercise acid-base balance recovery kinetics and subsequent high-intensity cycling time to exhaustion. In a counterbalanced, crossover design, nine healthy and active males (age: 23±2 years, height: 179±5 cm, body mass: 74±9 kg, peak mean minute power (WPEAK) 256±45 W, peak oxygen uptake (V̇O2PEAK) 46±8 ml.kg(-1).min(-1)) performed a graded incremental exercise test, two familiarisation and two experimental trials. Experimental trials consisted of cycling to volitional exhaustion (TLIM1) at 100% WPEAK on two occasions (TLIM1 and TLIM2) interspersed by a 90 min passive recovery period...
May 22, 2017: International Journal of Sport Nutrition and Exercise Metabolism
https://www.readbyqxmd.com/read/28527225/clinical-feasibility-of-gait-training-with-a%C3%A2-robotic-exoskeleton-wpal-in-an-individual-with-both-incomplete-cervical-and-complete-thoracic-spinal-cord-injury-a%C3%A2-case-study
#14
Shigeo Tanabe, Soichiro Koyama, Eiichi Saitoh, Satoshi Hirano, Kanan Yatsuya, Tetsuya Tsunoda, Masaki Katoh, Takeshi Gotoh, Ayako Furumoto
BACKGROUND: Patients with tetraplegia can achieve independent gait with lateral-type powered exoskeletons; it is unclear whether medial-type powered exoskeletons allow for this. OBJECTIVE: To investigate gait training with a medial-type powered exoskeleton wearable power-assist locomotor (WPAL) in an individual with incomplete cervical (C5) and complete thoracic (T12) spinal cord injury (SCI). METHODS: The 60-session program was investigated retrospectively using medical records...
May 19, 2017: NeuroRehabilitation
https://www.readbyqxmd.com/read/28527161/prognostic-indicators-of-response-to-plasmapheresis-in-patients-of-guillain-barre-syndrome
#15
H B Prasad, R T Borse, A N Avate, Assistant Professor In Medicine Palasdeokar
INTRODUCTION: Plasmapheresis is an important modality for the treatment of GBS. Moreover the response to this treatment modality is not same in all cases. We therefore studied the various prognostic indicators of response to plasmapheresis in patients of Guillain Barre Syndrome. MATERIAL AND METHODS: 40 patients were included in the study. Thorough clinical examination was done. Nerve conduction was done to find out the type of neuropathy. All were then given plasmapheresis...
April 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/28527012/effect-of-voluntary-hypocapnic-hyperventilation-or-moderate-hypoxia-on-metabolic-and-heart-rate-responses-during-high-intensity-intermittent-exercise
#16
Kohei Dobashi, Naoto Fujii, Kazuhito Watanabe, Bun Tsuji, Yosuke Sasaki, Tomomi Fujimoto, Satoru Tanigawa, Takeshi Nishiyasu
PURPOSE: To investigate the effect of voluntary hypocapnic hyperventilation or moderate hypoxia on metabolic and heart rate responses during high-intensity intermittent exercise. METHODS: Ten males performed three 30-s bouts of high-intensity cycling [Ex1 and Ex2: constant-workload at 80% of the power output in the Wingate anaerobic test (WAnT), Ex3: WAnT] interspaced with 4-min recovery periods under normoxic (Control), hypocapnic or hypoxic (2500 m) conditions...
May 19, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28525832/fabrication-of-porous-nanosheets-assembled-from-nico2o4-nio-electrode-for-electrochemical-energy-storage-application
#17
Chao Wei, Ying Huang, Menghua Chen, Jing Yan, Wen Yao, Xuefang Chen
In this work, The NiCo2O4/NiO electrode materials are successfully synthesized via hydrothermal and following calcination approach. Due to the distinctive porous nanosheets assembled structure through controlling effectively the feeding amount of HMT, the NiCo2O4/NiO electrode possesses excellent specific surface area and reasonable pore size distribution, which hence minimizes the intrinsic electrode resistance and improves the morphology and structure stability. Therefore, the NiCo2O4/NiO electrode delivers a superior specific capacitance (Csp) (992...
May 12, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28523905/highly-conductive-porous-transition-metal-dichalcogenides-via-water-steam-etching-for-high-performance-lithium-sulfur-batteries
#18
Zhubing Xiao, Zhi Yang, Liujiang Zhou, Linjie Zhang, Ruihu Wang
Lithium-sulfur (Li-S) batteries show significant advantages for next-generation energy storage systems owing to their high energy density and cost effectiveness. The main challenge in the development of long-life and high-performance Li-S batteries is how to simultaneously facilitate the redox kinetics of sulfur species and suppress the shuttle effect of polysulfides. In this contribution, we present a general and green water-steam-etched approach for fabricating H- and O-incorporated porous TiS2 (HOPT). The conductivity, porosity, chemisorptive capability and electrocatalytic activity of HOPT are enhanced significantly when compared with those of raw TiS2...
May 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28523755/asymmetric-supercapacitors-based-on-rgo-pmo12-as-a-positive-and-rgo-pw12-as-a-negative-electrode
#19
Deepak Dubal, Nilesh Chodankar, Ajayan Vinu, Do-Heyoung Kim, Pedro Gomez-Romero
Nanofabrication via "bottom-up" approach of hybrid electrode materials into well-defined architecture is essential for the next generation miniaturized energy storage devices. This paper describes the design and fabrication of reduced graphene oxide (rGO)/polyoxometalates (POMs) based hybrid electrode materials and their successful exploitation for asymmetric supercapacitor. Firstly, the redox active nanoclusters of POMs (phosphomolybdic acid (PMo12) and phosphotungstic acid (PW12)) are uniformly decorated on the surface of rGO nanosheets to take full advantage of both charge-storing mechanisms (faradaic from POMs and electric double layer from rGO)...
May 18, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28522819/elastocaloric-effect-and-superelastic-stability-in-ni-mn-in-co-polycrystalline-heusler-alloys-hysteresis-and-strain-rate-effects
#20
Binfeng Lu, Jian Liu
Controlling material hysteresis and working frequency variability are fundamentally important for refrigeration cycle efficiency and power density in solid-state cooling systems. For elastocaloric cooling, understanding the relationship between the width of the stress hysteresis and elastocaloric behaviour during superelastic cycles under varied strain rates is important. In this work, we report the effects of strain rate effects on the superelastic and elastocaloric responses in Ni45Mn50-xInxCo5 (x = 13...
May 18, 2017: Scientific Reports
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