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https://www.readbyqxmd.com/read/28068996/non-linear-parameters-of-specific-resistance-loops-to-characterise-obstructive-airways-diseases
#1
Marko Topalovic, Vasileios Exadaktylos, Thierry Troosters, Geert Celis, Jean-Marie Aerts, Wim Janssens
BACKGROUND: Specific resistance loops appear in different shapes influenced by different resistive properties of the airways, yet their descriptive ability is compressed to a single parameter - its slope. We aimed to develop new parameters reflecting the various shapes of the loop and to explore their potential in the characterisation of obstructive airways diseases. METHODS: Our study included 134 subjects: Healthy controls (N = 22), Asthma with non-obstructive lung function (N = 22) and COPD of all disease stages (N = 90)...
January 9, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28061834/prevalence-of-airflow-obstruction-in-patients-with-stable-systolic-heart-failure
#2
Morten Dalsgaard, Louis Lind Plesner, Morten Schou, Erik Kjøller, Jørgen Vestbo, Kasper Iversen
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is an important differential diagnosis in heart failure (HF). However, routine use of spirometry in outpatient HF clinics is not implemented. The aim of the present study was to determine the prevalence of both airflow obstruction and non obstructive lung function impairment in patients with HF and to examine the effect of optimal medical treatment for HF on lung function parameters. METHODS: Consecutive patients with HF (ejection fraction (EF) < 45%) and New York Heart Association (NYHA) functional class II-IV at 10 different outpatient heart failure clinics were examined with spirometry at their first visit and after optimal medical treatment for HF was achieved...
January 6, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/28058497/-a-rare-cause-of-severe-panniculitis
#3
C Fiehn
A 58-year-old patient presented with a severe, episodic panniculitis of the upper legs. Necrosis of the fatty tissue and a suspected superinfection led to amputation of one leg. The panniculitis was caused by a hereditary deficiency of alpha-1 antitrypsin (AAT) due to a ZZ mutation of the AAT gene. Neutrophilic panniculitis is found in 0.1% of patients with the ZZ mutation and therefore is the rarest clinical manifestation of AAT deficiency. With the exception of mild COPD, the patient had no other typical clinical symptoms of AAT deficiency...
January 5, 2017: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/28053518/initiation-of-triple-therapy-maintenance-treatment-among-patients-with-copd-in-the-us
#4
Jason C Simeone, Rakesh Luthra, Shuchita Kaila, Xiaoyun Pan, Tarun D Bhagnani, Jieruo Liu, Teresa K Wilcox
BACKGROUND: The Global Initiative for Chronic Obstructive Lung Disease (GOLD) recommends triple therapy (long-acting muscarinic receptor antagonists, long-acting beta-2 agonists, and inhaled corticosteroids) for patients with only the most severe COPD. Data on the proportion of COPD patients on triple therapy and their characteristics are sparse and dated. Objective 1 of this study was to estimate the proportion of all, and all treated, COPD patients receiving triple therapy. Objective 2 was to characterize those on triple therapy and assess the concordance of triple therapy use with GOLD guidelines...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28028752/cigarette-smoke-induced-pulmonary-inflammation-and-autophagy-are-attenuated-in-ephx2-deficient-mice
#5
Yunxiao Li, Ganggang Yu, Shaopeng Yuan, Chunting Tan, Puqiao Lian, Lixia Fu, Qi Hou, Bo Xu, Haoyan Wang
Cigarette smoke (CS) increases the risk of chronic obstructive pulmonary disease (COPD) by causing inflammation, emphysema, and reduced lung function. Additionally, CS can induce autophagy which contributes to COPD. Arachidonic acid-derived epoxyeicosatrienoic acids (EETs) have promising anti-inflammatory properties that may protect the heart and liver by regulating autophagy. For this reason, the effect of decreased soluble epoxide hydrolase (sEH, Ephx2)-mediated EET hydrolysis on inflammation, emphysema, lung function, and autophagy was here studied in CS-induced COPD in vivo...
December 27, 2016: Inflammation
https://www.readbyqxmd.com/read/28018674/early-phase-recovery-of-cardiorespiratory-measurements-after-maximal-cardiopulmonary-exercise-testing-in-patients-with-chronic-obstructive-pulmonary-disease
#6
Marie Bellefleur, David Debeaumont, Alain Boutry, Marie Netchitailo, Antoine Cuvelier, Jean-François Muir, Catherine Tardif, Jérémy Coquart
Background. This study investigated respiratory gas exchanges and heart rate (HR) kinetics during early-phase recovery after a maximal cardiopulmonary exercise test (CPET) in patients with chronic obstructive pulmonary disease (COPD) grouped according to airflow limitation. Methods. Thirty control individuals (control group: CG) and 81 COPD patients (45 with "mild" or "moderate" airflow limitation, COPDI-II, versus 36 with "severe" or "very severe" COPD, COPDIII-IV) performed a maximal CPET. The first 3 min of recovery kinetics was investigated for oxygen uptake ([Formula: see text]O2), minute ventilation ([Formula: see text]), respiratory equivalence, and HR...
2016: Pulmonary Medicine
https://www.readbyqxmd.com/read/28012491/associations-between-the-distance-covered-in-the-incremental-shuttle-walk-test-and-lung-function-and-health-status-in-patients-with-chronic-obstructive-pulmonary-disease
#7
Atsuhito Ushiki, Shuhei Nozawa, Masanori Yasuo, Kazuhisa Urushihata, Hiroshi Yamamoto, Masayuki Hanaoka, Keisaku Fujimoto
BACKGROUND: Field walk tests such as the incremental shuttle walk test (ISWT) are simple tests for assessing the degree of disability in individuals with chronic obstructive pulmonary disease (COPD). In the present study, the correlations between exercise performance in the ISWT, lung function, and health status were examined in patients with COPD of varying severities. METHODS: A retrospective examination of 277 COPD patients was performed using the ISWT and lung function tests along with assessment of health status using St...
January 2017: Respiratory Investigation
https://www.readbyqxmd.com/read/28005831/bronchoscopy-safety-in-patients-with-chronic-obstructive-lung-disease
#8
Christina R Bellinger, Irtaza Khan, Arjun B Chatterjee, Edward F Haponik
BACKGROUND: Flexible bronchoscopy is a safe and minimally invasive diagnostic tool used by pulmonologists, but few studies have prospectively compared outcomes in patients with objectively defined obstructive lung disease to those without obstruction. METHODS: We determined whether complications in patients undergoing moderate sedation bronchoscopy differ in those without obstruction compared with chronic obstructive pulmonary disease (COPD). We prospectively followed all patients undergoing moderate sedation bronchoscopy in an inpatient or outpatient setting...
December 21, 2016: Journal of Bronchology & Interventional Pulmonology
https://www.readbyqxmd.com/read/27997255/emphysema-on-thoracic-ct-and-exercise-ventilatory-inefficiency-in-mild-to-moderate-copd
#9
Joshua H Jones, Joel T Zelt, Daniel M Hirai, Camilla V Diniz, Aida Zaza, Denis E O'Donnell, J Alberto Neder
There is growing evidence that emphysema on thoracic computed tomography (CT) is associated with poor exercise tolerance in COPD patients with only mild-to-moderate airflow obstruction. We hypothesized that an excessive ventilatory response to exercise (ventilatory inefficiency) would underlie these abnormalities. In a prospective study, 19 patients (FEV1 = 82 ± 13%, 12 Global Initiative for Chronic Obstructive Lung Disease (GOLD) stage 1) and 26 controls underwent an incremental exercise test. Ventilatory inefficiency was assessed by the ventilation ([Formula: see text]E)/CO2 output ([Formula: see text]CO2) nadir...
December 20, 2016: COPD
https://www.readbyqxmd.com/read/27984243/chronic-obstructive-pulmonary-disease-and-sleep-related-disorders
#10
Sheila C Tsai
PURPOSE OF REVIEW: Sleep related disorders are common and under-recognized in the chronic obstructive pulmonary disease (COPD) population. COPD symptoms can disrupt sleep. Similarly, sleep disorders can affect COPD. This review highlights the common sleep disorders seen in COPD patients, their impact, and potential management. RECENT FINDINGS: Treatment of sleep disorders may improve quality of life in COPD patients. Optimizing inhaler therapy improves sleep quality...
December 15, 2016: Current Opinion in Pulmonary Medicine
https://www.readbyqxmd.com/read/27983888/eosinophilic-and-neutrophilic-airway-inflammation-in-the-phenotyping-of-mild-to-moderate-asthma-and-chronic-obstructive-pulmonary-disease
#11
Katarzyna Górska, Magdalena Paplińska-Goryca, Patrycja Nejman-Gryz, Krzysztof Goryca, Rafał Krenke
Asthma and chronic obstructive pulmonary disease (COPD) are heterogeneous diseases with different inflammatory phenotypes. Various inflammatory mediators play a role in these diseases. The aim of this study was to analyze the neutrophilic and eosinophilic airway and systemic inflammation as the phenotypic characterization of patients with asthma and COPD. Twenty-four patients with asthma and 33 patients with COPD were enrolled in the study. All the patients were in mild-to-moderate stage of disease, and none of them were treated with inhaled corticosteroids...
December 16, 2016: COPD
https://www.readbyqxmd.com/read/27965420/microalbuminuria-in-subjects-with-copd-relationship-to-the-new-version-of-global-initiative-for-chronic-obstructive-lung-disease-staging
#12
Fulsen Bozkus, Nursel Dikmen, Anil Samur
BACKGROUND: Microalbuminuria, used as a marker of endothelial dysfunction, is a predictor of mortality for any reason and of cardiovascular events. Recent research on the management of COPD has focused more on comorbidities, including cardiovascular events. The objective of this study was to investigate the incidence of microalbuminuria and whether it is associated with physiological and clinical features in a subject group that was classified in line with the new version of the Global Initiative for Chronic Obstructive Lung Disease stages...
December 13, 2016: Respiratory Care
https://www.readbyqxmd.com/read/27956034/classification-of-patients-with-chronic-obstructive-pulmonary-disease-according-to-the-latin-american-thoracic-association-alat-staging-systems-and-the-global-initiative-for-chronic-obstructive-pulmonary-disease-gold
#13
Maria Montes de Oca, María Victorina López Varela, María Eugenia Laucho-Contreras, Alejandro Casas, Eduardo Schiavi, Alejandra Rey, Alejandra Silva
INTRODUCTION: Several classification systems use different criteria when assessing COPD stages. The objective of this study was to compare the prevalence and distribution of COPD stagesusing Global initiative for chronic Obstructive Lung Disease (GOLD) recommendationsand Latin American Thoracic Association (ALAT) guidelinesin a primary-care population. METHODS: Subjects attending routine primary care visits, ≥40 years of age, current or former smokers or exposed to biomass, completed a questionnaire and performed spirometry...
December 9, 2016: Archivos de Bronconeumología
https://www.readbyqxmd.com/read/27932877/factors-influencing-exacerbation-related-self-management-in-patients-with-copd-a-qualitative-study
#14
Yjg Korpershoek, Scjm Vervoort, Lit Nijssen, Jca Trappenburg, M J Schuurmans
BACKGROUND: In patients with COPD, self-management skills are important to reduce the impact of exacerbations. However, both detection and adequate response to exacerbations appear to be difficult for some patients. Little is known about the underlying process of exacerbation-related self-management. Therefore, the objective of this study was to identify and explain the underlying process of exacerbation-related self-management behavior. METHODS: A qualitative study using semi-structured in-depth interviews was performed according to the grounded theory approach, following a cyclic process in which data collection and data analysis alternated...
2016: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/27932148/low-dose-spinal-block-with-continuous-epidural-infusion-for-renal-transplantation-in-a-patient-with-alport-syndrome-a-case-report
#15
F Gobbi, G Sales, P Bretto, P P Donadio, L Brazzi
OBJECTIVE: We aim to describe management of a patient receiving renal transplantation for chronic renal failure due to Alport syndrome with low dose of intrathecal bupivacaine and continuous epidural infusion of local anesthetic. CASE REPORT: A 38-years-old man with chronic renal failure secondary to Alport syndrome underwent kidney transplantation. Because of a high risk of respiratory and cardiovascular complications related to the patient's baseline lung disease and abnormalities in heart conduction, we selected combined spinal-epidural anesthesia...
November 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27923937/low-volume-whole-body-vibration-training-improves-exercise-capacity-in-subjects-with-mild-to-severe-copd
#16
Marc Spielmanns, Tobias Boeselt, Rainer Gloeckl, Anja Klutsch, Henrike Fischer, Henryk Polanski, Christoph Nell, Jan H Storre, Wolfram Windisch, Andreas R Koczulla
BACKGROUND: The objective of this study was to investigate the benefits of a low-volume out-patient whole-body vibration training (WBVT) program on exercise capacity in comparison with a calisthenics training program in subjects with COPD. METHODS: In this single-center randomized controlled trial, 29 subjects with mild to severe COPD were randomized to WBVT or to calisthenics training, including relaxation and breathing retraining in combination with calisthenics exercises...
December 6, 2016: Respiratory Care
https://www.readbyqxmd.com/read/27920515/effect-of-elom-080-on-exacerbations-and-symptoms-in-copd-patients-with-a-chronic-bronchitis-phenotype-a-post-hoc-analysis-of-a-randomized-double-blind-placebo-controlled-clinical-trial
#17
Kai-Michael Beeh, Jutta Beier, Henning Candler, Thomas Wittig
BACKGROUND: Treating symptoms and preventing exacerbations are key components of chronic obstructive pulmonary disease (COPD) long-term management. Recently, a more tailored treatment approach has been proposed, in particular for two well-established clinical phenotypes, frequent exacerbators and chronic bronchitis-dominant COPD. ELOM-080 has demonstrated clinical efficacy in treating symptoms and preventing exacerbations in subjects with chronic bronchitis. However, little is known about the potential effects of ELOM-080 in COPD patients...
2016: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/27915422/state-of-the-art-review-of-the-right-ventricle-in-copd-patients-it-is-time-to-look-closer
#18
REVIEW
Daniela Graner Schuwartz Tannus-Silva, Marcelo Fouad Rabahi
Since the first description of pulmonary circulation in the 16th century, the knowledge of the complex interaction between the heart and lungs has greatly improved. Hypoxemia plays a classical role in the development of complications such as pulmonary hypertension and right ventricle (RV) dysfunction in patients presenting with chronic obstructive pulmonary disease (COPD). However, more recent results have revealed the presence of RV vascular structural and functional changes even in patients with mild COPD, without hypoxemia or pulmonary hypertension at rest...
December 3, 2016: Lung
https://www.readbyqxmd.com/read/27911009/echocardiographic-predictors-of-outcome-in-patients-with-chronic-obstructive-pulmonary-disease
#19
Ivan Stankovic, Robert Marcun, Aleksandra Janicijevic, Jerneja Farkas, Sasa Kadivec, Ivan Ilic, Aleksandar N Neskovic, Mitja Lainscak
BACKGROUND: We aimed to assess the relationship between echocardiographic characteristics and mortality in patients with chronic obstructive pulmonary disease (COPD). METHODS: We prospectively studied 154 patients (mean age 71 ± 10 years, 71% male) with COPD. All patients underwent transthoracic Doppler echocardiography within 48 hours of hospital admission. Primary endpoint was all-cause mortality during a median period of 22 months. RESULTS: Mildly elevated tricuspid regurgitation pressure and mitral E/e' ratio were the most commonly encountered echocardiographic abnormalities, observed in 60% and 56% of patients, respectively...
December 2, 2016: Journal of Clinical Ultrasound: JCU
https://www.readbyqxmd.com/read/27906423/analysis-of-factors-influenced-by-the-effectiveness-of-non-invasive-ventilation-in-the-treatment-of-acute-exacerbation-of-chronic-obstructive-pulmonary-disease-with-different-severities
#20
J-J Zhu, L-J Liu
OBJECTIVE: To investigate the correlation of levels of procalcitonin (PCT) and blood lactic acid with the effectiveness of the non-invasive ventilation (NIV) in the treatment of acute exacerbation of chronic obstructive pulmonary disease (AECOPD) with different severities. PATIENTS AND METHODS: We used a case-control method to study patients who were admitted for AECOPD to the ICU at the Second Affiliated Hospital of Soochow University from January 1, 2012, to December 31, 2014...
November 2016: European Review for Medical and Pharmacological Sciences
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