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https://www.readbyqxmd.com/read/29135394/real-life-profile-of-asthma-and-chronic-obstructive-pulmonary-disease-patients-in-turkey
#1
Zeynep Mısırlıgil, Arif Çımrın, Hakan Günen, Tevfik Özlü, Aykut Çilli, Levent Akyıldız, Hasan Bayram, Bilun Gemicioğlu, Esra Uzaslan, Öznur Abadoğlu, Mecit Suerdem
Introduction: Despite the presentation of similar symptoms, the airway diseases have different underlying pathophysiological processes and must be distinguished to enable the administration of appropriate treatment. In several studies the clinician- and patient-related causes of poor compliance to treatment in asthma/chronic obstructive pulmonary disease (COPD) patients have been evaluated. This study aimed to determine the clinical and sociodemographic characteristics of newly diagnosed treatment-naïve asthma and COPD patients in Turkey...
September 2017: Tüberküloz Ve Toraks
https://www.readbyqxmd.com/read/29110280/body-weight-and-mortality-in-copd-focus-on-the-obesity-paradox
#2
REVIEW
Francesco Spelta, A M Fratta Pasini, L Cazzoletti, M Ferrari
The positive association between overweight, obesity, and cardiovascular and all-cause mortality is well established, even though this relation is typically U shaped with an increased risk also in low-weight subjects. However, being overweight or obese has been associated with a better prognosis in subjects suffering from chronic diseases, id est the "obesity paradox". In both community-dwelling and hospitalized patients with COPD, several studies have reported a significant protective effect of obesity on all-cause mortality, indicating that also in obstructive pulmonary diseases, an obesity paradox may be present...
November 6, 2017: Eating and Weight Disorders: EWD
https://www.readbyqxmd.com/read/29108795/severity-of-copd-and-its-relationship-with-il-10
#3
Bruna S A Silva, Fábio S Lira, Dionei Ramos, Juliana S Uzeloto, Fabrício Eduardo Rossi, Ana Paula C F Freire, Rebeca N Silva, Iara B Trevisan, Luis Alberto Gobbo, Ercy M C Ramos
BACKGROUND: The present study was designed to compare inflammatory and metabolic responses according to severity of airflow among patients with COPD and to verify the relationship between pulmonary function, body composition, metabolic and inflammatory profile. METHODS: Fifty-one patients with mild to very severe COPD were recruited and divided according lung function in Mild-moderate (GOLD 1-2) n= 21; Severe (GOLD 3) n=25 and Very severe (GOLD 4) n=5. Patients were submitted to assessments of lung function (spirometry), functional exercise capacity (6-min walk test), body composition (Octopolar bioelectrical impedance), metabolic profile (glucose, triglycerides, total cholesterol, HDL-cholesterol and albumin (colorimetric assay)) and inflammatory profile (cytokines: IL-6, IL-10, TNF-α and IL-15 (ELISA))...
November 3, 2017: Cytokine
https://www.readbyqxmd.com/read/29108664/the-effect-of-acute-and-7-days-dietary-nitrate-on-mechanical-efficiency-exercise-performance-and-cardiac-biomarkers-in-patients-with-chronic-obstructive-pulmonary-disease
#4
Rosanne J H C G Beijers, Stephanie M D Huysmans, Coby van de Bool, Boris R M Kingma, Lex B Verdijk, Luc J C van Loon, Steven J R Meex, Harry R Gosker, Annemie M W J Schols
BACKGROUND & AIMS: Many COPD patients have a reduced exercise capacity and mechanical efficiency and are at increased cardiometabolic risk. This study aimed to assess acute and 7-days effects of dietary nitrate on mechanical efficiency, exercise performance and cardiac biomarkers in patients with COPD. METHODS: This double-blind, randomized cross-over placebo controlled trial included 20 mild-to-moderate COPD patients (66.6 ± 7.5 years) with moderate exercise impairments and decreased mechanical efficiency, normal BMI (26 ± 3 kg/m(2)) but high prevalence of abdominal obesity (83...
October 31, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29100446/chronic-obstructive-pulmonary-disease-and-risk-of-lung-cancer-a-meta-analysis-of-prospective-cohort-studies
#5
Xinyue Zhang, Ning Jiang, Lijuan Wang, Huaman Liu, Rong He
Background: Studies exploring the association between chronic obstructive pulmonary disease (COPD) and lung cancer have yielded mixed results. We conducted a meta-analysis of the published prospective cohort studies to have a clear understanding about this association. Methods: We searched the MEDLINE and EMBASE databases from inception to December 31, 2016. Bibliographies were also reviewed for additional information. Random-effects model was used to calculate summary relative risk (SRR) and corresponding 95% confidence interval (CI)...
September 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29081264/health-status-of-copd-patients-undergoing-pulmonary-rehabilitation-a-comparative-responsiveness-of-the-cat-and-sgrq
#6
Anabel Sciriha, Stephen Lungaro-Mifsud, Josianne Scerri, Rosalie Magro, Liberato Camilleri, Stephen Montefort
The St. George's Respiratory Questionnaire (SGRQ) and chronic obstructive pulmonary disease (COPD) assessment test (CAT) are the measures used to assess health status. This study aims to examine the responsiveness of these tools by severity of dyspnoea category in patients with COPD. Forty-nine COPD patients who underwent a 12-week pulmonary rehabilitation (PR) programme were assessed at baseline, 12 weeks and at 28-week follow-up. Patients were categorized into two groups by severity of dyspnoea category (i...
November 2017: Chronic Respiratory Disease
https://www.readbyqxmd.com/read/29075544/imaging-histopathologic-and-treatment-nuances-of-pulmonary-carcinosarcoma
#7
Tyler Gleason, Michael Haas, Brian H Le
A 76-year-old female with coronary artery disease, chronic obstructive pulmonary disease, diabetes mellitus type II, and 40 pack-year smoking history presented with a four-day history of cough, productive of green-yellow sputum. Chest X-ray revealed opacification of the left upper lung field, and computed tomography (CT) of the chest showed a large cavitary lesion invading the T2-T3 vertebral bodies, extending into the epidural space, giving rise to mild cord compression. Biopsy of the lesion revealed a poorly differentiated neoplasm composed of distinct epithelial and mesenchymal components, consistent with carcinosarcoma...
2017: Case Reports in Radiology
https://www.readbyqxmd.com/read/29074814/exacerbation-risk-and-characterisation-of-the-uk-s-asthma-population-from-infants-to-old-age
#8
Chloe I Bloom, Francis Nissen, Ian J Douglas, Liam Smeeth, Paul Cullinan, Jennifer K Quint
BACKGROUND: Few studies have examined the characteristics of a general asthma population; most have focused on more severe patients or severe exacerbations. METHODS: This population-based cohort study, from April 2007 to September 2015, used linked primary and secondary care electronic healthcare records (Clinical Practice Research Datalink, Hospital Episode Statistics). Characteristics of four age cohorts, 'Under 5s', '5 to 17s', '18 to 54s', '55+', were described...
October 26, 2017: Thorax
https://www.readbyqxmd.com/read/29074714/potential-for-non-invasive-assessment-of-lung-inhomogeneity-using-highly-precise-highly-time-resolved-measurements-of-gas-exchange
#9
James E Mountain, Peter Santer, David Patrick O'Neill, Nicholas M J Smith, Luca Ciaffoni, John H Couper, Grant A D Ritchie, Gus Hancock, Jonathan P Whiteley, Peter A Robbins
Inhomogeneity in the lung impairs gas exchange and can be an early marker of lung disease. We hypothesised that highly precise measurements of gas exchange contain sufficient information to quantify many aspects of the inhomogeneity non-invasively. Our aim was to explore whether one parameterization of lung inhomogeneity could both fit such data and provide reliable parameter estimates. A mathematical model of gas exchange in an inhomogeneous lung was developed, containing inhomogeneity parameters for compliance, vascular conductance and deadspace, all relative to lung volume...
October 26, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29054717/-evaluation-of-quality-of-life-qol-of-tunisians-patients-with-copd
#10
R Khalladi, I Gargouri, M Mahjoub, S Belhareth, H Ben Saad
AIM: To test the Arabic version of the St. George's Hospital Respiratory Questionnaire (SGRQ) in stable Tunisian COPD patients. HYPOTHESES: A correlation coefficient between the post-bronchodilator FEV1 and the "Total" score of SGRQ higher than "-0.40", and QOL scores lower in COPD with "mild to moderate airway obstruction" than in those with "severe to very severe airway obstruction" will be in favor of a possible application of the Arabic version of the SGRQ in Tunisians COPD patients...
October 2017: Revue de Pneumologie Clinique
https://www.readbyqxmd.com/read/29042706/protective-effects-of-bisoprolol-against-acute-exacerbation-in-moderate-to-severe-chronic-obstructive-pulmonary-disease
#11
Akihiko Taniguchi, Nobuaki Miyahara, Naohiro Oda, Daisuke Morichika, Eiki Ichihara, Isao Oze, Yasushi Tanimoto, Hirohisa Ichikawa, Utako Fujii, Mitsune Tanimoto, Arihiko Kanehiro, Katsuyuki Kiura
Although recent retrospective studies suggested that the use of β-blockers appears to help improve the mortality rate and decrease the rate of exacerbation in chronic obstructive pulmonary disease (COPD) patients with heart failure, the effects of β-blockers on COPD patients without heart failure have not been established. Based on previous reports, we have launched a multicenter, prospective, single-arm phase II study to evaluate the preventive effect of the cardioselective β-blocker bisoprolol in COPD exacerbation, in Japanese individuals with moderate-to-severe COPD who do not have heart failure but do have hypertension requiring the use of medication...
October 2017: Acta Medica Okayama
https://www.readbyqxmd.com/read/29042486/parameters-for-simulation-of-adult-patients-during-mechanical-ventilation
#12
Jean-Michel Arnal, Aude Garnero, Mathieu Saoli, Robert L Chatburn
BACKGROUND: Simulation studies are often used to examine ventilator performance. However, there are no standards for selecting simulation parameters. This study collected data in passively-ventilated adult human subjects and summarized the results as a set of parameters that can be used for simulation studies of intubated, passive, adult subjects with normal lungs, COPD, or ARDS. METHODS: Consecutive adult patients admitted to the ICU were included if they were deeply sedated and mechanically ventilated for <48 h without any spontaneous breathing activity...
October 17, 2017: Respiratory Care
https://www.readbyqxmd.com/read/29027309/the-importance-of-symptoms-in-the-longitudinal-variability-of-clusters-in-copd-patients-a-validation-study
#13
Juan P de Torres, Jose M Marin, Cristina Martinez-Gonzalez, Pilar de Lucas-Ramos, Borja Cosio, Ciro Casanova
BACKGROUND AND OBJECTIVE: Cluster analysis has been utilized to explore phenotypic heterogeneity in chronic obstructive pulmonary disease (COPD). To date, little is known about the longitudinal variability of clusters in COPD patients. We aimed to evaluate the 2-year cluster variability in stable COPD patients. METHODS: We evaluated the following variables in COPD patients at baseline and 2 years later: age, gender, pack-year history, body mass index (BMI), modified Medical Research Council (MMRC) scale, 6-min walking distance (6MWD), spirometry and COPD Assessment Test (CAT)...
October 12, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/29025888/effect-of-erdosteine-on-the-rate-and-duration-of-copd-exacerbations-the-restore-study
#14
Roberto W Dal Negro, Jadwiga A Wedzicha, Martin Iversen, Giovanni Fontana, Clive Page, Arrigo F Cicero, Edoardo Pozzi, Peter M A Calverley
Oxidative stress contributes to chronic obstructive pulmonary disease (COPD) exacerbations and antioxidants can decrease exacerbation rates, although we lack data about the effect of such drugs on exacerbation duration.The RESTORE (Reducing Exacerbations and Symptoms by Treatment with ORal Erdosteine in COPD) study was a prospective randomised, double-blind, placebo-controlled study, enrolling patients aged 40-80 years with Global Initiative for Chronic Obstructive Lung Disease stage II/III. Patients received erdosteine 300 mg twice daily or placebo added to usual COPD therapy for 12 months...
October 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29016325/increased-mortality-in-seasonal-h3n2-patients-compared-with-those-with-pandemic-2009-h1n1-in-taiwan-2009-2010
#15
Shi-Yu Huang, Wen-Chi Huang, Yi-Chun Chen, Ching-Yen Tsai, Ing-Kit Lee
We conducted a retrospective study to compare clinical and laboratory findings between 1) severe influenza A and mild influenza A and 2) pandemic 2009 H1N1 (pdm09 A/H1) and seasonal H3N2 (A/H3) from 2009 to 2010. A total of 526 (mean age, 13.6 years; 447 pdm09 A/H1, 79 seasonal A/H3) patients were included, 41 (7.8%) with severe influenza (mean age, 28.1 years; 26 pdm09 A/H1, 15 seasonal A/H3). Influenza-associated complications were pneumonia (75.6%), meningoencephalitis (14.6%), acute kidney injury (14.6%), and acute respiratory distress syndrome (12...
September 25, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28994143/correlates-of-physical-activity-among-depressed-older-people-in-six-low-income-and-middle-income-countries-a-community-based-cross-sectional-study
#16
Davy Vancampfort, Brendon Stubbs, Nicola Veronese, James Mugisha, Nathalie Swinnen, Ai Koyanagi
OBJECTIVE: Despite the benefits of physical activity (PA) in older people with depression, many do not comply with the International PA guidelines. Thus, we investigated what factors influence PA participation among 915 community-dwelling older adults (aged ≥65 years) with depression in 6 low-income and middle-income countries (LMICs). METHODS: Cross-sectional data were analyzed from the World Health Organization's Study on Global Ageing and Adult Health. The sample was restricted to those with DSM-IV depression or receiving depression treatment in the last 12 months...
October 10, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28987804/pharmacodynamics-pharmacokinetics-and-safety-of-revefenacin-td-4208-a-long-acting-muscarinic-antagonist-in-patients-with-chronic-obstructive-pulmonary-disease-copd-results-of-two-randomized-double-blind-phase-2-studies
#17
Dean Quinn, Christopher N Barnes, Wayne Yates, David L Bourdet, Edmund J Moran, Peter Potgieter, Andrew Nicholls, Brett Haumann, Dave Singh
BACKGROUND: Revefenacin (TD-4208) is a potent, lung-selective, long-acting muscarinic antagonist currently in development for once-daily treatment of chronic obstructive pulmonary disease (COPD). We evaluated the pharmacodynamics (bronchodilator activity), pharmacokinetics (PK) and safety of single- and multiple-dose administrations of nebulized revefenacin in two clinical trials (Study 0059 and Study 0091) in patients with moderate to severe COPD. METHODS: In Study 0059, 32 patients were randomized to receive a single dose of revefenacin (350 or 700 μg), active control ipratropium (500 μg) or placebo inhalation solution administered via standard jet nebulizer in a double-blind, crossover fashion...
October 4, 2017: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28986334/chronic-obstructive-pulmonary-disease-as-a-risk-factor-for-ventricular-arrhythmias-independent-of-left-ventricular-function
#18
Tomas Konecny, Kiran R Somers, Jae Yoon Park, Alan John, Marek Orban, Rahul Doshi, Paul D Scanlon, Samuel J Asirvatham, Charanjit S Rihal, Peter A Brady
BACKGROUND: The association between chronic obstructive pulmonary disease (COPD) and sudden cardiac death has not been fully elucidated. OBJECTIVE: The purpose of this study was to investigate whether decreased left ventricular ejection fraction (LVEF) can explain the increased rate of ventricular tachycardia (VT) in COPD. METHODS: This retrospective study included consecutive adult patients who underwent pulmonary function testing (PFT), Holter monitoring, and transthoracic echocardiography...
October 3, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28986100/reduced-shear-stress-and-associated-aortic-deformation-in-the-thoracic-aorta-of-patients-with-chronic-obstructive-pulmonary-disease
#19
Michal Schäfer, Vitaly O Kheyfets, Alex J Barker, Kurt Stenmark, Kendall S Hunter, P Mason McClatchey, J Kern Buckner, T Brett Reece, Omid Jazaeri, Brett E Fenster
OBJECTIVE: Central aortic stiffness and chronic obstructive pulmonary disease (COPD) are associated with increased incidence of devastating aortopathies. However, the exact mechanism leading to elevated aortic stiffness in patients with COPD is unknown. The purpose of this study was to quantify flow and shear hemodynamic indices, known markers of vascular remodeling, in the thoracic aorta of patients with mild to moderate COPD (n = 16) and to compare these results with an age-matched control group (n = 10)...
October 3, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28979162/pain-problems-for-patients-with-mild-and-moderate-chronic-obstructive-pulmonary-disease-a-community-based-study-in-shanghai
#20
Tian Xiao, Xianfeng Zhou, Yun He, Yue Chen, Hua Qiu, Sheng Zhang, Xianglin Wei, Kang Wu, Xiaonan Ruan, Na Wang, Chaowei Fu
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a great public health burden worldwide. Few studies have focused on pain problems in patients with mild and moderate COPD in Chinese community settings. METHODS: A cross-sectional study of 283 patients with mild and moderate COPD was conducted in six communities that were randomly sampled in Pudong New Area of Shanghai, China, in 2016. A face-to-face interview was conducted to collect data on personal characteristics and health conditions...
2017: Journal of Pain Research
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