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Kasper Stokbro, Torben Thygesen
PURPOSE: Inferior maxillary repositioning is among the least stable and least predictable orthognathic procedures. The purpose of this study was to investigate whether posterior movement occurred with inferior maxillary repositioning and to analyze potential causes. MATERIALS AND METHODS: This retrospective observational study evaluated all consecutive patients treated at the Department of Oral and Maxillofacial Surgery of the Odense University Hospital (Odense, Denmark) with inferior maxillary repositioning from 2011 to 2013...
May 28, 2018: Journal of Oral and Maxillofacial Surgery
Kerry L O'Brien, Scott A Shainker, Evelyn L Lockhart
Obstetric hemorrhage is one of the leading, as well as one of the most treatable, causes of maternal morbidity and mortality worldwide. As obstetric hemorrhage often occurs in patients without risk factors, there is virtually unanimous agreement from obstetric professional societies to establish obstetric hemorrhage protocols in anticipation of these emergencies. These protocols involve multidisciplinary teams in which the transfusion service plays an essential and vital role. This manuscript will examine the epidemiology of obstetric hemorrhage, risk factors that may be present, and recommendations for these protocols, with a focus on massive transfusion protocols, laboratory testing, cell salvage and use of pharmacologic adjuvant therapy including tranexamic acid and factor concentrates...
May 31, 2018: Transfusion Medicine Reviews
Linda A Dimeff, David A Jobes, Samantha A Chalker, Brian M Piehl, Leticia Lobo Duvivier, Benjamin C Lok, Mohan S Zalake, Julie Chung, Kelly Koerner
OBJECTIVE: A novel avatar system (Virtual Collaborative Assessment and Management of Suicidality System; V-CAMS) for suicidal patients and medical personnel in emergency departments (EDs) was developed and evaluated. V-CAMS facilitates the delivery of CAMS and other evidence-based interventions to reduce unnecessary hospitalization, readmissions, and suicide following an ED visit. METHOD: Using iterative user-centered design with 24 suicidal patients, an avatar prototype, "Dr...
May 20, 2018: General Hospital Psychiatry
Cláudia C Miranda, Tiago G Fernandes, Maria Margarida Diogo, Joaquim M S Cabral
A low percentage of novel drug candidates succeed and reach the end of the drug discovery pipeline, mainly due to poor initial screening and assessment of the effects of the drug and its metabolites over various tissues in the human body. For that, emerging technologies involving the production of organoids from human pluripotent stem cells (hPSCs) and the use of organ-on-a-chip devices are showing great promise for developing a more reliable, rapid and cost-effective drug discovery process when compared with the current use of animal models...
June 21, 2018: Bioengineering
Takahisa Kawamura, Hidefumi Kasai, Valentina Fermanelli, Toshiaki Takahashi, Yukinori Sakata, Toshiyuki Matsuoka, Mika Ishii, Yusuke Tanigawara
Post-marketing surveillance is useful to collect safety data in real-world clinical settings. In this study, we firstly applied the post-marketing real-world data on a mechanistic model analysis for neutropenic profiles of eribulin in patients with recurrent or metastatic breast cancer (RBC/MBC). Demographic and safety data were collected using an active surveillance method from eribulin-treated RBC/MBC patients. Changes in neutrophil counts over time were analyzed using a mechanistic pharmacodynamic model...
June 22, 2018: Cancer Science
Basavaraj Biradar, Arun Sharma, Amarinder Singh Malhi, Sanjeev Kumar
Unilateral pulmonary vein atresia is a rare entity, usually congenital in origin. It is thought to result from failure of incorporation of common pulmonary vein to left atrium. Patients often present with recurrent chest infections and haemoptysis during infancy or early childhood. Associated anomalies are commonly present in these cases. Pulmonary angiography is generally used for definitive diagnosis; however, characteristic imaging findings on latest multislice CT can be virtually diagnostic.
June 21, 2018: BMJ Case Reports
Dietmar Dammerer, David Putzer, Alexander Wurm, Michael Liebensteiner, Michael Nogler, Martin Krismer
OBJECTIVE: Knee arthroscopies are very common orthopedic procedures. For a number of reasons, including increased public awareness for medical errors, patient safety, strict regulations governing duty-hours for residents, surgeons' liability, and an increasing emphasis on the efficient use of operating room time, interest in simulator training is on the rise. It was the purpose of this study to analyze learning curves of medical students and orthopedic resident surgeons using a virtual knee arthroscopy simulator...
June 18, 2018: Journal of Surgical Education
Hiroki Oe, Nobuhisa Watanabe, Toru Miyoshi, Kazuhiro Osawa, Teiji Akagi, Susumu Kanazawa, Hiroshi Ito
BACKGROUND: Management of adult congenital heart disease (ACHD) patients requires understanding of its complex morphology and functional features. An innovative imaging technique has been developed to display a virtual multi-planar reconstruction obtained from contrast-enhanced multidetector-computed tomography (MDCT) corresponding to the same cross-sectional image from transthoracic echocardiography (TTE). The aim of this study is to assess the usefulness of this imaging technology in ACHD patients...
June 18, 2018: Journal of Cardiology
Bart Vandenberghe
Dental imaging has seen a rapid technological advance over the last several years. Not only has most x-ray based diagnostic technology been digitized, with the possibility of low dose 3D computed tomography imaging, but many novel optical imaging techniques have now also been adopted in a more therapeutic imaging of the dental patient. When combining and manipulating such different digital image data, clinicians can now easily plan and simulate treatments on-screen, use 3D printed models and aids to assist in accurate transfer of the virtual planning or even follow-up their treatments over time...
July 2018: Journal of Dentistry
Haang Jeung, Stephan Walther, Christoph W Korn, Katja Bertsch, Sabine C Herpertz
Although emotional reactivity to social rejection has been examined in patients with borderline personality disorder (BPD) in several studies, the effects of other aspects of social feedback, such as evaluation of one's opinions that concern self-esteem, have not been addressed yet. The objective of this study was to examine emotional responses of BPD patients after exchanging personal opinions in a new, ecologically valid virtual peer interaction paradigm ("chatroom paradigm"). In this paradigm, 21 BPD patients and 21 healthy controls received peer feedback on their own statements and rated the intensity of their own emotional responses (happiness, sadness, anger, and shame) and the self or other affirmation in response to agreement, disagreement, and neutral statements...
June 21, 2018: Personality Disorders
Shahar A Glomski, Jeremy R Wortman, Jennifer W Uyeda, Aaron D Sodickson
PURPOSE: To compare dual-energy CT (DECT) iodine overlay images with renal mass protocol CT in the evaluation of polycystic kidneys with respect to reading time, diagnostic confidence, and detection of renal lesions that are not definitively benign. METHODS: Following IRB approval, portal venous phase dual-source DECT scans performed between September 2013 and February 2016 from 55 patients (mean age 67 ± 15 years, 31 male, 24 female) with polycystic kidneys (4 or more cysts) were included...
June 20, 2018: Abdominal Radiology
Sherry Pagoto, Bengisu Tulu, Emmanuel Agu, Molly E Waring, Jessica L Oleski, Danielle E Jake-Schoffman
BACKGROUND: Reviews of weight loss mobile apps have revealed they include very few evidence-based features, relying mostly on self-monitoring. Unfortunately, adherence to self-monitoring is often low, especially among patients with motivational challenges. One behavioral strategy that is leveraged in virtually every visit of behavioral weight loss interventions and is specifically used to deal with adherence and motivational issues is problem solving. Problem solving has been successfully implemented in depression mobile apps, but not yet in weight loss apps...
June 20, 2018: JMIR MHealth and UHealth
Cristina Santoro, Gabriele Quintavalle, Giancarlo Castaman, Erminia Baldacci, Antonietta Ferretti, Federica Riccardi, Annarita Tagliaferri
Hemophilia B (HB) is an X-linked bleeding disorder caused by deficiency of factor IX (FIX). Patients with the severe form (FIX <1%) account approximately for 30 to 45% of persons with HB and usually suffer from recurrent joint, soft-tissue, and muscle bleeds. The availability of safe plasma-derived and recombinant products has virtually abolished the risk of viral infections and the adoption of prophylactic regimens has attenuated the impact of hemophilic arthropathy. Therefore, the development of an inhibitor against FIX is currently the most serious complication that can still occur in the new generations of HB patients...
June 20, 2018: Seminars in Thrombosis and Hemostasis
Won-Seok Kim, Sungmin Cho, Seo Hyun Park, Ji-Young Lee, SuYeon Kwon, Nam-Jong Paik
BACKGROUND: We designed this study to prove the efficacy of the low-cost Kinect-based virtual rehabilitation (VR) system for upper limb recovery among patients with subacute stroke. METHODS: A double-blind, randomized, sham-controlled trial was performed. A total of 23 subjects with subacute stroke (<3 months) were allocated to sham (n = 11) and real VR group (n = 12). Both groups participated in a daily 30-minute occupational therapy for upper limb recovery for 10 consecutive weekdays...
June 2018: Medicine (Baltimore)
Emily Morell Balkin, Matt S Zinter, Satish K Rajagopal, Roberta L Keller, Jeffrey R Fineman, Martina A Steurer
OBJECTIVES: The disease burden and mortality of children with pulmonary hypertension are significantly higher than for the general PICU population. We aimed to develop a risk-adjustment tool predicting PICU mortality for pediatric pulmonary hypertension patients: the Pediatric Index of Pulmonary Hypertension Intensive Care Mortality score. DESIGN: Retrospective analysis of prospectively collected multicenter pediatric critical care data. SETTING: One-hundred forty-three centers submitting data to Virtual Pediatric Systems database between January 1, 2009, and December 31, 2015...
June 19, 2018: Pediatric Critical Care Medicine
David Dreizin, Arthur J Nam, Jeffrey Hirsch, Mark P Bernstein
This article reviews the conceptual framework, available evidence, and practical considerations pertaining to nascent and emerging advances in patient-centered CT-imaging and CT-guided surgery for maxillofacial trauma. These include cinematic rendering-a novel method for advanced 3D visualization, incorporation of quantitative CT imaging into the assessment of orbital fractures, low-dose CT imaging protocols made possible with contemporary scanners and reconstruction techniques, the rapidly growing use of cone-beam CT, virtual fracture reduction with design software for surgical pre-planning, the use of 3D printing for fabricating models and implants, and new avenues in CT-guided computer-aided surgery...
June 20, 2018: Emergency Radiology
Chin Siang Ong, Gerard Deib, Pooja Yesantharao, Ye Qiao, Jina Pakpoor, Narutoshi Hibino, Ferdinand Hui, Juan R Garcia
Objectives: Virtual reality (VR) allows users to experience realistic, immersive 3D virtual environments with the depth perception and binocular field of view of real 3D settings. Newer VR technology has now allowed for interaction with 3D objects within these virtual environments through the use of VR controllers. This technical note describes our preliminary experience with VR as an adjunct tool to traditional angiographic imaging in the preprocedural workup of a patient with a complex pseudoaneurysm...
June 2018: Journal of Vascular and Interventional Neurology
Milan N A van der Kuil, Johanna M A Visser-Meily, Andrea W M Evers, Ineke J M van der Ham
Acquired brain injury patients often report navigation impairments. A cognitive rehabilitation therapy has been designed in the form of a serious game. The aim of the serious game is to aid patients in the development of compensatory navigation strategies by providing exercises in 3D virtual environments on their home computers. The objective of this study was to assess the usability of three critical gaming attributes: movement control in 3D virtual environments, instruction modality and feedback timing. Thirty acquired brain injury patients performed three tasks in which objective measures of usability were obtained...
2018: Frontiers in Psychology
Isabelle Riederer, Alexander A Fingerle, Thomas Baum, Jan S Kirschke, Ernst J Rummeny, Peter B Noël, Daniela Pfeiffer
The aim was to evaluate Virtual Non-Contrast (VNC)-CT images for the detection of acute infarcts in the brain after mechanical thrombectomy using a dual-layer spectral CT. 29 patients between September 2016 and February 2017 with unenhanced head spectral-CT after mechanical thrombectomy and available follow-up images (MRI, n:26; CT, n:3) were included. VNC-CT and conventional CT (CT) images were reconstructed using dedicated software. Based on those, contrast-to-noise ratio (CNR), and the volume of infarction were measured semi-automatically in VNC-CT, CT and MRI...
June 19, 2018: Scientific Reports
Hyemin Lee, Jooly Cha, Youn-Sic Chun, Minji Kim
BACKGROUNDS: The occlusal registration of virtual models taken by intraoral scanners sometimes shows patterns which seem much different from the patients' occlusion. Therefore, this study aims to evaluate the accuracy of virtual occlusion by comparing virtual occlusal contact area with actual occlusal contact area using a plaster model in vitro. METHODS: Plaster dental models, 24 sets of Class I models and 20 sets of Class II models, were divided into a Molar, Premolar, and Anterior group...
June 19, 2018: BMC Oral Health
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