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Charles Faisant, Guillaume Armengol, Laurence Bouillet, Isabelle Boccon-Gibod, Céline Villier, Hervé Lévesque, Judith Cottin, Nathalie Massy, Ygal Benhamou
INTRODUCTION: Bradykinin-mediated angioedema (AE) is a rare side effect of some medications, including angiotensin converting enzyme inhibitors (ACEi) and angiotensin receptor blockers (ARB). In France, side-effects to treatments are reported to the national pharmacovigilance database. METHODS: The national MedDRA database was searched using the term "angioedema". Patients were included if they met the clinical criteria corresponding to bradykinin-mediated AE, if their C1-inhibitor levels were normal, and if they were treated with an ACEi or an ARB...
January 2016: Journal of Clinical Immunology
Mindaugas Kirkus, Stefan Knippenberg, David Beljonne, Jérôme Cornil, René A J Janssen, Stefan C J Meskers
We describe the synthesis and photophysical properties of a series of derivatives of pyrrolo[3,2-b]pyrrole-2,5(1H,4H)-dione-3,6-diyl (iDPP) linked to two oligothiophenes of variable length (nT). The iso-DPP-oligothiophenes (iDPPnTs) differ from the common pyrrolo[3,4-c]pyrrole-1,4(2H,5H)-dione-3,6-diyl-oligothiophene analogues (DPPnTs) by a different orientation of the two lactam rings in the bicyclic iDPP unit compared to DPP. In contrast to the highly fluorescent DPPnTs, the new isomeric iDPPnTs exhibit only very weak fluorescence...
April 4, 2013: Journal of Physical Chemistry. A
Chamukuttan Snehalatha, Simon Mary, Sundaram Selvam, Cholaiyil Kizhakathil Sathish Kumar, Samith Babu Ananth Shetty, Arun Nanditha, Ambady Ramachandran
OBJECTIVE: The Indian Diabetes Prevention Programme-1 (IDPP-1) showed that lifestyle modification (LSM) and metformin were effective for primary prevention of diabetes in subjects with impaired glucose tolerance (IGT). Among subjects followed up for 3 years (n = 502), risk reductions versus those for the control group were 28.5, 26.4, and 28.2% in LSM, metformin (MET), and LSM plus MET groups, respectively. In this analysis, the roles of changes in secretion and action of insulin in improving the outcome were studied...
October 2009: Diabetes Care
Ambady Ramachandran, Chamukuttan Snehalatha, Annasami Yamuna, Simon Mary, Zhang Ping
OBJECTIVE: In the Indian Diabetes Prevention Programme (IDPP), a 3-year randomized, controlled trial, lifestyle modification (LSM) and metformin helped to prevent type 2 diabetes in subjects with impaired glucose tolerance (IGT). The direct medical costs and cost-effectiveness of the interventions relative to the control group are reported here. RESEARCH DESIGN AND METHODS: Relative effectiveness and costs of interventions (LSM, metformin, and LSM and metformin) in the IDPP were estimated from the health care system perspective...
October 2007: Diabetes Care
A Ramachandran, C Snehalatha, S Mary, B Mukesh, A D Bhaskar, V Vijay
AIMS/HYPOTHESIS: Lifestyle modification helps in the primary prevention of diabetes in multiethnic American, Finnish and Chinese populations. In a prospective community-based study, we tested whether the progression to diabetes could be influenced by interventions in native Asian Indians with IGT who were younger, leaner and more insulin resistant than the above populations. METHODS: We randomised 531 (421 men 110 women) subjects with IGT (mean age 45.9+/-5.7 years, BMI 25...
February 2006: Diabetologia
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