keyword
MENU ▼
Read by QxMD icon Read
search

Jayawardena

keyword
https://www.readbyqxmd.com/read/29145822/ultrasonographic-parameters-of-the-liver-spleen-and-kidneys-among-a-cohort-of-school-children-in-sri-lanka
#1
Dianne Tania Dayanthi Warnakulasuriya, Pattiya Pathirennahalage Uddika Chamila Peries, Yaddehi Arachchillage Chaminda Rathnasekara, KaluArachchige Thushari Madurika Jayawardena, Angappulige Upasena, Anada Rajitha Wickremasinghe
BACKGROUND: Liver, spleen and kidney dimensions on ultrasonography vary with the age, weight and ethnicity. Reference standards of these parameters for normal Sri Lankan children are not available. Our aim was to establish normative data for longitudinal length of liver, spleen and kidneys in healthy children. METHOD: Three hundred fifty-seven children, 5-13 years of age were selected from two randomly selected schools in the Gampaha district in the western province of Sri Lanka...
November 16, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/29136286/brompheniramine-and-chlorpheniramine-pharmacokinetics-following-single-dose-oral-administration-in-children-aged-2-to-17-years
#2
Sudam Pathirana, Shyamalie Jayawardena, Suzanne Meeves, Gary A Thompson
Two pediatric studies characterized brompheniramine and chlorpheniramine pharmacokinetics in a total of 72 subjects, aged 2 to 17 years. A single age-/weight-based oral dose, ranging from 1 to 4 mg, was administered with 2 to 6 oz of water at least 2 hours after a light breakfast. Plasma samples were obtained before and for 72 hours after dosing and analyzed using high-pressure liquid chromatography-tandem mass spectrometry. Pharmacokinetic parameters were estimated using noncompartmental methods; relationships with age were assessed using linear regression...
November 14, 2017: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29072815/zinc-supplementation-in-pre-diabetes-a-randomized-double-blind-placebo-controlled-clinical-trial
#3
Priyanga Ranasinghe, Wasundara Sevwandi Wathurapatha, Priyadarshani Galappatthy, Prasad Katulanda, Ranil Jayawardena, Godwin Roger Constantine
BACKGROUND: To evaluate the effects of Zinc supplementation on glycaemic control, other cadio-metabolic/anthropometric parameters and progression of disease in pre-diabetes. METHODS: The clinical trial was conducted as a randomized, double-blind, placebo-controlled Phase II clinical trial for a period of 12 months. The treatment group received Zinc (20mg daily). A total of 200 subjects with pre-diabetes were recruited for the study and randomly assigned into the treatment and control groups (1:1)...
October 26, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/29055625/coronary-artery-calcium-progression-is%C3%A2-associated-with-coronary-plaque-volume-progression-results-from-a-quantitative-semiautomated-coronary%C3%A2-artery%C3%A2-plaque-analysis
#4
Indre Ceponiene, Rine Nakanishi, Kazuhiro Osawa, Mitsuru Kanisawa, Negin Nezarat, Sina Rahmani, Kendall Kissel, Michael Kim, Eranthi Jayawardena, Alexander Broersen, Pieter Kitslaar, Matthew J Budoff
OBJECTIVES: The aim of this study was to determine whether coronary artery calcium (CAC) progression was associated with coronary plaque progression on coronary computed tomographic angiography. BACKGROUND: CAC progression and coronary plaque characteristics are associated with incident coronary heart disease. However, natural history of coronary atherosclerosis has not been well described to date, and the understanding of the association between CAC progression and coronary plaque subtypes such as noncalcified plaque progression remains unclear...
October 14, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29036669/comparative-genome-and-transcriptome-analyses-reveal-adaptations-to-opportunistic-infections-in-woody-plant-degrading-pathogens-of-botryosphaeriaceae
#5
Ji Ye Yan, Wen Sheng Zhao, Zhen Chen, Qi Kai Xing, Wei Zhang, K W Thilini Chethana, Min Feng Xue, Jian Ping Xu, Alan J L Phillips, Yong Wang, Jian Hua Liu, Mei Liu, Ying Zhou, Ruvishika S Jayawardena, Ishara S Manawasinghe, Jin Bao Huang, Guang Hang Qiao, Chun Yuan Fu, Fei Fei Guo, Asha J Dissanayake, You Liang Peng, Kevin D Hyde, Xing Hong Li
Botryosphaeriaceae are an important fungal family that cause woody plant diseases worldwide. Recent studies have established a correlation between environmental factors and disease expression; however, less is known about factors that trigger these diseases. The current study reports on the 43.3 Mb de novo genome of Lasiodiplodia theobromae and five other genomes of Botryosphaeriaceae pathogens. Botryosphaeriaceous genomes showed an expansion of gene families associated with cell wall degradation, nutrient uptake, secondary metabolism and membrane transport, which contribute to adaptations for wood degradation...
October 3, 2017: DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes
https://www.readbyqxmd.com/read/28991483/vasoactive-intestinal-peptide-nanomedicine-for-the-management-of-inflammatory-bowel-disease
#6
Dulari Jayawardena, Arivarasu N Anbazhagan, Grace Guzman, Pradeep K Dudeja, Hayat Onyuksel
Inflammatory bowel disease (IBD) is a chronic relapsing disorder of the intestine, with increasing incidence worldwide. At present, the management of IBD is an unmet medical need due to the ineffectiveness of currently available drugs in treating all patients, and there is strong demand for novel therapeutics. In this regard, vasoactive intestinal peptide, a potent anti-inflammatory endogenous hormone, has shown promise in managing multiple immune disorders in animal models. However, when administered in the free form, VIP undergoes rapid degradation in vivo, and with continuous infusion, it causes severe dose limiting side effects...
November 6, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28962661/cinnamomum-zeylanicum-ceylon-cinnamon-as-a-potential-pharmaceutical-agent-for-type-2-diabetes-mellitus-study-protocol-for-a-randomized-controlled-trial
#7
Priyanga Ranasinghe, Priyadarshani Galappaththy, Godwin Roger Constantine, Ranil Jayawardena, Hasitha Dhananjaya Weeratunga, Sirimal Premakumara, Prasad Katulanda
BACKGROUND: Previous studies have explored the anti-diabetic effects of Cinnamomum cassia extract in vivo and in vitro. However, there are no studies at present exploring the effects of the indigenous species of Sri Lankan cinnamon (Cinnamomum zeylanicum) in patients with diabetes mellitus. The present study aims to evaluate the potential effects of Cinnamomum zeylanicum extract as a pharmaceutical agent in patients with type-2 diabetes mellitus. METHODS/DESIGN: The study will be conducted as a randomized, double-blind, placebo-controlled clinical trial for a period of 4 months at the Medical Clinic, University Medical Unit, National Hospital of Sri Lanka...
September 29, 2017: Trials
https://www.readbyqxmd.com/read/28865957/zinc-binds-non-cooperatively-to-human-liver-metallothionein-2a-at-physiological-ph
#8
Devika P Jayawardena, Ilka U Heinemann, Martin J Stillman
Maintenance of the homeostasis of zinc is very important in regulating bodily functions. There are over 300 Zn-dependent enzymes identified where Zn(II) plays a structural or catalytic role. However, an excess of Zn(II) in a cell is toxic and free Zn(II) is tightly controlled. Metallothioneins (MTs) are small cysteine rich proteins that can bind up to seven Zn(II) and act as a Zn(II) reservoir. The MT2a isoform is predominantly found in the liver. This study focused on designing an MT2a construct of recombinant human MT2a to determine the Zn(II) binding profile of MT2a in vitro...
November 4, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28777120/multicenter-aids-cohort-study-quantitative-coronary-plaque-progression-study-rationale-and-design
#9
Rine Nakanishi, Wendy S Post, Kazuhiro Osawa, Eranthi Jayawardena, Michael Kim, Nasim Sheidaee, Negin Nezarat, Sina Rahmani, Nicholas Kim, Nicolai Hathiramani, Shriraj Susarla, Frank Palella, Mallory Witt, Michael J Blaha, Todd T Brown, Lawrence Kingsley, Sabina A Haberlen, Christopher Dailing, Matthew J Budoff
BACKGROUND AND AIM: The association of HIV with coronary atherosclerosis has been established; however, the progression of coronary atherosclerosis over time among participants with HIV is not well known. The Multicenter AIDS Cohort Study Quantitative Coronary Plaque Progression Study is a large prospective multicenter study quantifying progression of coronary plaque assessed by serial coronary computed tomography angiography (CTA). PATIENTS AND METHODS: HIV-infected and uninfected men who were enrolled in the Multicenter AIDS Cohort Study Cardiovascular Substudy were eligible to complete a follow-up contrast coronary CTA 3-6 years after baseline...
August 2, 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/28693601/effects-of-the-plate-model-as-part-of-dietary-intervention-on-modification-of-selected-cardiometabolic-risk-factors-in-post-myocardial-infarction-patients-study-protocol-for-a-randomized-controlled-trial
#10
Ranil Jayawardena, Pasindu Fernando, Niroshan Lokunarangoda, Anidu Keerthi Pathirana
BACKGROUND: Cardiovascular disease remains the leading cause of morbidity and mortality worldwide, and there is a rising global burden. The effects of diet on cardiometabolic risk factors have been studied extensively. Healthy eating as a cost-effective approach to risk reduction in post-myocardial infarction patients is proven to be beneficial, and the "plate model" is one of the practical methods to achieve this objective. METHODS/DESIGN: The study will be conducted as a randomized, single-blind, controlled clinical trial for a period of 3 months...
July 10, 2017: Trials
https://www.readbyqxmd.com/read/28663602/genera-of-phytopathogenic-fungi-gophy-1
#11
Y Marin-Felix, J Z Groenewald, L Cai, Q Chen, S Marincowitz, I Barnes, K Bensch, U Braun, E Camporesi, U Damm, Z W de Beer, A Dissanayake, J Edwards, A Giraldo, M Hernández-Restrepo, K D Hyde, R S Jayawardena, L Lombard, J Luangsa-Ard, A R McTaggart, A Y Rossman, M Sandoval-Denis, M Shen, R G Shivas, Y P Tan, E J van der Linde, M J Wingfield, A R Wood, J Q Zhang, Y Zhang, P W Crous
Genera of Phytopathogenic Fungi (GOPHY) is introduced as a new series of publications in order to provide a stable platform for the taxonomy of phytopathogenic fungi. This first paper focuses on 21 genera of phytopathogenic fungi: Bipolaris, Boeremia, Calonectria, Ceratocystis, Cladosporium, Colletotrichum, Coniella, Curvularia, Monilinia, Neofabraea, Neofusicoccum, Pilidium, Pleiochaeta, Plenodomus, Protostegia, Pseudopyricularia, Puccinia, Saccharata, Thyrostroma, Venturia and Wilsonomyces. For each genus, a morphological description and information about its pathology, distribution, hosts and disease symptoms are provided...
March 2017: Studies in Mycology
https://www.readbyqxmd.com/read/28568743/interventions-for-treatment-and-or-prevention-of-alcohol-hangover-systematic-review
#12
REVIEW
Ranil Jayawardena, Thulasika Thejani, Priyanga Ranasinghe, Dinithi Fernando, Joris C Verster
OBJECTIVE: To evaluate new research conducted over the past few years (2009-2016) assessing the effectiveness of potentially curative and/or preventive methods of alcohol hangover. METHODS: Data were retrieved by a 4-stage systematic search process. A search of the online Pubmed and Scopus databases were performed, using a combination of keywords: "Alcohol," "Ethanol," and "C2 H5 OH," in combination with the terms "Hangover," "Treatment," and "Prevention." The search comprised studies listed between January 1, 2009 and June 30, 2016...
May 31, 2017: Human Psychopharmacology
https://www.readbyqxmd.com/read/28474750/heavy-metal-induced-toxicity-in-the-indian-green-frog-biochemical-and-histopathological-alterations
#13
Uthpala Apekshani Jayawardena, Preethika Angunawela, Deepthi Devika Wickramasinghe, Wanigasekara Daya Ratnasooriya, Preethi Vidya Udagama
Heavy metal contamination may have adverse effects on wetland biota, particularly on amphibians. Severe immunotoxic effects elicited in Euphlyctis hexadactylus (Indian green frog) because of metal exposure (Cd, Cr, Cu, Pb, and Zn) in the Bellanwila-Attidiya Sanctuary, a polluted urban wetland in Sri Lanka, provided the rationale for the present study. We evaluated the biochemical and histopathological effects of this metal contamination with a reference E. hexadactylus population and a laboratory exposure group that was subjected to 28 d of exposure to a mixture of Cd, Cr, Cu, Pb, and Zn (5 ppm in each mixture)...
October 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/28446195/mature-leaf-concentrate-of-sri-lankan-wild-type-carica-papaya-linn-modulates-nonfunctional-and-functional-immune-responses-of-rats
#14
Chanika Dilumi Jayasinghe, Dinara S Gunasekera, Nuwan De Silva, Kithmini Kawya Mandakini Jayawardena, Preethi Vidya Udagama
BACKGROUND: The leaf concentrate of Carica papaya is a traditionally acclaimed immunomodulatory remedy against numerous diseases; nonetheless comprehensive scientific validation of this claim is limited. The present study thus investigated the immunomodulatory potential of Carica papaya mature leaf concentrate (MLCC) of the Sri Lankan wild type cultivar using nonfunctional and functional immunological assays. METHODS: Wistar rats (N = 6/ group) were orally gavaged with 3 doses (0...
April 26, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28403141/vamp3-syb-and-ykt6-are-required-for-the-fusion-of-constitutive-secretory-carriers-with-the-plasma-membrane
#15
David E Gordon, Joanne Chia, Kamburpola Jayawardena, Robin Antrobus, Frederic Bard, Andrew A Peden
The cellular machinery required for the fusion of constitutive secretory vesicles with the plasma membrane in metazoans remains poorly defined. To address this problem we have developed a powerful, quantitative assay for measuring secretion and used it in combination with combinatorial gene depletion studies in Drosophila cells. This has allowed us to identify at least three SNARE complexes mediating Golgi to PM transport (STX1, SNAP24/29 and Syb; STX1, SNAP24/29 and YKT6; STX4, SNAP24 and Syb). RNAi mediated depletion of YKT6 and VAMP3 in mammalian cells also blocks constitutive secretion suggesting that YKT6 has an evolutionarily conserved role in this process...
April 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28400040/a-comparison-of-rescue-and-primary-percutaneous-coronary-interventions-for-acute-st-elevation-myocardial-infarction
#16
M B Faslur Rahuman, Jayanthimala B Jayawardena, George R Francis, Niraj Mahboob, Wasantha Kumara A H T, Aruna Wijesinghe, Rashan Haniffa, Ranithrie Ariyapperuma, Abbyramy Paramanayakam, Pubudu A De Silva
OBJECTIVE: To perform a comparative analysis of in-hospital results obtained from patients with acute ST elevation myocardial infarction (STEMI), who underwent rescue or primary percutaneous coronary intervention (PCI). The aim is to determine rescue PCI as a practical option for patients with no immediate access to primary PCI. METHODS: From the Cardiology PCI Clinic of the National Hospital of Sri Lanka (NHSL), we selected all consecutive patients presenting with acute STEMI </=24h door-to-balloon delay for primary PCI and </=72h door-to-balloon delay, (90min after failed thrombolysis) for rescue PCI, from March 2013 to April 2015 and their in-hospital results were analyzed, comparing rescue and primary PCI patients...
April 2017: Indian Heart Journal
https://www.readbyqxmd.com/read/28398221/amyloid-fibrils-from-hemoglobin
#17
Nadishka Jayawardena, Manmeet Kaur, Smitha Nair, Jenny Malmstrom, David Goldstone, Leonardo Negron, Juliet A Gerrard, Laura J Domigan
Amyloid fibrils are a class of insoluble protein nanofibers that are formed via the self-assembly of a wide range of peptides and proteins. They are increasingly exploited for a broad range of applications in bionanotechnology, such as biosensing and drug delivery, as nanowires, hydrogels, and thin films. Amyloid fibrils have been prepared from many proteins, but there has been no definitive characterization of amyloid fibrils from hemoglobin to date. Here, nanofiber formation was carried out under denaturing conditions using solutions of apo-hemoglobin extracted from bovine waste blood...
April 11, 2017: Biomolecules
https://www.readbyqxmd.com/read/28395159/poly-hema-co-hema-pfpa-synthesis-and-preparation-of-stable-micelles-encapsulating-imaging-nanoparticles
#18
Madanodaya Sundhoro, Jaehyeung Park, Kalana W Jayawardana, Xuan Chen, H Surangi N Jayawardena, Mingdi Yan
We report the preparation of stable micelles from random copolymers of 2-hydroxyethyl methacrylate (HEMA) and perfluorophenyl azide (PFPA)-derivatized HEMA (HEMA-PFPA). The copolymers were synthesized by RAFT polymerization at room temperature under mild conditions without affecting the azide functionality. Upon addition of water to the copolymer solution in DMSO, the random copolymers self-assembled into micelles even at the percentage of HEMA-PFPA as low as 4.5%. The size of the micelles can be controlled by the molecular weight and the concentration of the copolymer, and the percentage of HEMA-PFPA in the copolymer...
March 24, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28385693/expression-and-localization-of-vpac1-the-major-receptor-of-vasoactive-intestinal-peptide-along-the-length-of-the-intestine
#19
Dulari Jayawardena, Grace Guzman, Ravinder K Gill, Waddah A Alrefai, Hayat Onyuksel, Pradeep K Dudeja
Vasoactive intestinal peptide (VIP) is an endogenous neuropeptide with a broad array of physiological functions in many organs including the intestine. Its actions are mediated via G protein-coupled receptors, and vasoactive intestinal peptide receptor 1 (VPAC1) is the key receptor responsible for majority of VIP's biological activity. The distribution of VPAC1 along the length of the gastrointestinal tract and its subcellular localization in intestinal epithelial cells have not been fully characterized. The current studies were undertaken to determine VPAC1 distribution and localization so that VIP-based therapies can be targeted to specific regions of the intestine...
July 1, 2017: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/28244702/health-insurance-or-subsidy-has-universal-advantage-for-management-of-hospital-malnutrition-unrelated-to-gdp
#20
COMPARATIVE STUDY
Stanislaw Klek, Michael Chourdakis, Dima Abdulqudos Abosaleh, Alejandra Amestoy, Hyun Wook Baik, Gertrudis Baptista, Rocco Barazzoni, Ryoji Fukushima, Josef Hartono, Ranil Jayawardena, Rafael Jimenez Garcia, Zeljko Krznaric, Ibolya Nyulasi, Gabriela Parallada, Eliza Mei Perez Francisco, Marina Panisic-Sekeljic, Mario Perman, Arina Prins, Isabel Martinez Del Rio Requejo, Ravinder Reddy, Pierre Singer, Marianna Sioson, Andrew Ukleja, Carla Vartanian, Nicolas Velasco Fuentes, Dan Linetzky Waitzberg, Steve Leonce Zoungrana, Aleksander Galas
BACKGROUND AND OBJECTIVES: Protein-energy and micronutrient malnutrition are global public health problems which, when not prevented and severe, require medical management by clinicians with nutrition expertise, preferably as a collectively skilled team, especially when disease-related. This study aimed to investigate barriers and facilitators of clinical nutrition services (CNS), especially the use of oral, enteral (EN) and parenteral (PN) nutrition in institutional and home settings...
March 2017: Asia Pacific Journal of Clinical Nutrition
keyword
keyword
39370
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"