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https://www.readbyqxmd.com/read/29753654/correlation-of-arterial-stiffness-with-left-atrial-volume-index-and-left-ventricular-mass-index-in-young-adults-evaluation-by-coronary-computed-tomography-angiography
#1
Kazuhiro Osawa, Rine Nakanishi, Toru Miyoshi, Sina Rahmani, Indre Ceponiene, Negin Nezarat, Mitsuru Kanisawa, Hong Qi, Eranthi Jayawardena, Nicholas Kim, Hiroshi Ito, Matthew J Budoff
BACKGROUND: Increased arterial stiffness is reportedly associated with cardiac remodelling, including the left atrium and left ventricle, in middle-aged and older adults. However, little is known about this association in young adults. METHODS: In total, 73 patients (44 (60%) men) aged 25 to 45 years with suspected coronary artery disease were included in the analysis. The left atrial volume index (LAVI), left ventricular volume index (LVVI), and left ventricular mass index (LVMI) were measured using coronary computed tomography angiography (CCTA)...
April 26, 2018: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29732715/evaporative-cooling-hydrogel-packaging-for-storing-biologics-outside-of-the-cold-chain
#2
Shiran Ferber, Adam M Behrens, Kevin J McHugh, Evan M Rosenberg, Allison R Linehan, James L Sugarman, Hapuarachchige Surangi N Jayawardena, Robert Langer, Ana Jaklenec
Stabilizing thermolabile pharmaceuticals outside of the cold chain has the potential to alleviate some of the logistical and monetary burden of providing health care access in the developing world. Evaporative cooling hydrogel packaging is designed to extend the storage stability of existing pharmaceutical products without the need for reformulation. Hydrogels with high water content and reversible hydrophilicity offer a promising platform for reducing storage temperatures without refrigeration. As a model, poly(N-isopropylacrylamide) is selected as a basis for creating a potentially low cost and easy-to-fabricate hydrogels...
May 7, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29720578/targeting-inflammatory-monocytes-in-sepsis-associated-encephalopathy-and-long-term-cognitive-impairment
#3
Graciela Andonegui, Erin L Zelinski, Courtney L Schubert, Derrice Knight, Laura A Craig, Brent W Winston, Simon C Spanswick, Björn Petri, Craig N Jenne, Janice C Sutherland, Rita Nguyen, Natalie Jayawardena, Margaret M Kelly, Christopher J Doig, Robert J Sutherland, Paul Kubes
Sepsis-associated encephalopathy manifesting as delirium is a common problem in critical care medicine. In this study, patients that had delirium due to sepsis had significant cognitive impairments at 12-18 months after hospital discharge when compared with controls and Cambridge Neuropsychological Automated Test Battery-standardized scores in spatial recognition memory, pattern recognition memory, and delayed-matching-to-sample tests but not other cognitive functions. A mouse model of S. pneumoniae pneumonia-induced sepsis, which modeled numerous aspects of the human sepsis-associated multiorgan dysfunction, including encephalopathy, also revealed similar deficits in spatial memory but not new task learning...
May 3, 2018: JCI Insight
https://www.readbyqxmd.com/read/29685823/the-benefits-of-yoga-practice-compared-to-physical-exercise-in-the-management-of-type-2-diabetes-mellitus-a-systematic-review-and-meta-analysis
#4
REVIEW
Ranil Jayawardena, Priyanga Ranasinghe, Tharindu Chathuranga, Piyusha Milani Atapattu, Anoop Misra
Yoga is increasingly used as an adjunctive therapy in the management of Type-2 Diabetes Mellitus (T2DM). The present study aims to systematically evaluate the literature and perform a meta-analysis on the effects of yoga practice compared to physical exercise in the management of T2DM. Data were obtained using a stepwise search process using keywords in the following online medical databases; PubMed, Web of Science and Scopus. All controlled clinical trials involving patients with T2DM, comparing yoga as an intervention with physical exercise and evaluating glycaemic control and other outcomes between the intervention and control groups were included in the analysis...
April 18, 2018: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29601475/effects-of-drought-on-nutrient-uptake-and-the-levels-of-nutrient-uptake-proteins-in-roots-of-drought-sensitive-and-tolerant-grasses
#5
Deepesh R Bista, Scott A Heckathorn, Dileepa M Jayawardena, Sasmita Mishra, Jennifer K Boldt
Climate change will increase drought in many regions of the world. Besides decreasing productivity, drought also decreases the concentration (%) of nitrogen (N) and phosphorous (P) in plants. We investigated if decreases in nutrient status during drought are correlated with decreases in levels of nutrient-uptake proteins in roots, which has not been quantified. Drought-sensitive ( Hordeum vulgare , Zea mays ) and -tolerant grasses ( Andropogon gerardii ) were harvested at mid and late drought, when we measured biomass, plant %N and P, root N- and P-uptake rates, and concentrations of major nutrient-uptake proteins in roots (NRT1 for NO₃, AMT1 for NH₄, and PHT1 for P)...
March 30, 2018: Plants (Basel, Switzerland)
https://www.readbyqxmd.com/read/29572635/automated-estimation-of-image-quality-for-coronary-computed-tomographic-angiography-using-machine-learning
#6
Rine Nakanishi, Sethuraman Sankaran, Leo Grady, Jenifer Malpeso, Razik Yousfi, Kazuhiro Osawa, Indre Ceponiene, Negin Nazarat, Sina Rahmani, Kendall Kissel, Eranthi Jayawardena, Christopher Dailing, Christopher Zarins, Bon-Kwon Koo, James K Min, Charles A Taylor, Matthew J Budoff
OBJECTIVES: Our goal was to evaluate the efficacy of a fully automated method for assessing the image quality (IQ) of coronary computed tomography angiography (CCTA). METHODS: The machine learning method was trained using 75 CCTA studies by mapping features (noise, contrast, misregistration scores, and un-interpretability index) to an IQ score based on manual ground truth data. The automated method was validated on a set of 50 CCTA studies and subsequently tested on a new set of 172 CCTA studies against visual IQ scores on a 5-point Likert scale...
March 23, 2018: European Radiology
https://www.readbyqxmd.com/read/29468747/biocompatible-semiconductor-quantum-dots-as-cancer-imaging-agents
#7
REVIEW
Kevin J McHugh, Lihong Jing, Adam M Behrens, Surangi Jayawardena, Wen Tang, Mingyuan Gao, Robert Langer, Ana Jaklenec
Approximately 1.7 million new cases of cancer will be diagnosed this year in the United States leading to 600 000 deaths. Patient survival rates are highly correlated with the stage of cancer diagnosis, with localized and regional remission rates that are much higher than for metastatic cancer. The current standard of care for many solid tumors includes imaging and biopsy with histological assessment. In many cases, after tomographical imaging modalities have identified abnormal morphology consistent with cancer, surgery is performed to remove the primary tumor and evaluate the surrounding lymph nodes...
May 2018: Advanced Materials
https://www.readbyqxmd.com/read/29444370/cryptosporidium-parvum-disrupts-intestinal-epithelial-barrier-function-via-altering-expression-of-key-tight-junction-and-adherens-junction-proteins
#8
Anoop Kumar, Ishita Chatterjee, Arivarasu N Anbazhagan, Dulari Jayawardena, Shubha Priyamvada, Waddah A Alrefai, Jun Sun, Alip Borthakur, Pradeep K Dudeja
Infection with the protozoan parasite Cryptosporidium parvum (CP) causes cryptosporidiosis, a widespread diarrhoeal disease. Impaired intestinal epithelial barrier function and increased permeability are most commonly associated with diarrhoeal diseases caused by enteric infections. However, studies on barrier disruption and underlying mechanisms in cryptosporidiosis are extremely limited. Epithelial tight junctions (TJs) and adherens junctions (AJs) are important in maintaining barrier integrity. Therefore, we examined the effects of CP infection on paracellular permeability and on the expression of the major TJ and AJ proteins utilising in vitro, ex vivo, and in vivo models...
February 14, 2018: Cellular Microbiology
https://www.readbyqxmd.com/read/29405833/evidence-based-use-of-perioperative-antibiotics-in-otolaryngology
#9
Priyesh N Patel, Asitha D L Jayawardena, Rachel L Walden, Edward B Penn, David O Francis
Objective To identify and clarify current evidence supporting and disputing the effectiveness of perioperative antibiotic use for common otolaryngology procedures. Data Sources PubMed, Embase (OVID), and CINAHL (EBSCO). Review Methods English-language, original research (systematic reviews/meta-analyses, randomized control trials, prospective or retrospective cohort studies, case-control studies, or case series) studies that evaluated the role of perioperative antibiotic use in common otolaryngology surgeries were systematically extracted using standardized search criteria by 2 investigators independently...
January 1, 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29370854/dual-function-of-active-constituents-from-bark-of-ficus-racemosa-l-in-wound-healing
#10
Nisansala Swarnamali Bopage, G M Kamal Bandara Gunaherath, Kithsiri Hector Jayawardena, Sushila Chandrani Wijeyaratne, Ajita Mahendra Abeysekera, Seneviratne Somaratne
BACKGROUND: Different parts including the latex of Ficus racemosa L. has been used as a medicine for wound healing in the Ayurveda and in the indigenous system of medicine in Sri Lanka. This plant has been evaluated for its wound healing potential using animal models. The aim of this study was to obtain an insight into the wound healing process and identify the potential wound healing active substance/s present in F. racemosa L. bark using scratch wound assay (SWA) as the in-vitro assay method...
January 25, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29355679/efficacy-and-safety-of-dupilumab-in-perennial-allergic-rhinitis-and-comorbid-asthma
#11
Steven F Weinstein, Rohit Katial, Shyamalie Jayawardena, Gianluca Pirozzi, Heribert Staudinger, Laurent Eckert, Vijay N Joish, Nikhil Amin, Jaman Maroni, Paul Rowe, Neil M H Graham, Ariel Teper
BACKGROUND: Dupilumab, an anti-IL-4 receptor α mAb, inhibits IL-4/IL-13 signaling, key drivers of type 2/TH 2 immune diseases (eg, atopic/allergic disease). In a pivotal, phase 2b study (NCT01854047), dupilumab reduced severe exacerbations, improved lung function and quality of life, and was generally well tolerated in patients with uncontrolled persistent asthma despite using medium-to-high-dose inhaled corticosteroids plus long-acting β2-agonists. OBJECTIVE: To examine dupilumab's effect on the 22-item Sino-Nasal Outcome Test (SNOT-22) total score and its allergic rhinitis (AR)-associated items in asthma patients with comorbid perennial allergic rhinitis (PAR)...
January 31, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29336283/headaches-and-facial-pain-in-rhinology
#12
Asitha D L Jayawardena, Rakesh Chandra
"Sinus headache" is a common chief complaint that often leads patients to an otolaryngologist's office. Because facial pain may or may not be sinogenic in origin, the otolaryngologist should be equipped to evaluate and treat or to appropriately refer these patients. Analysis of current data indicates that the majority of patients who present with sinus headaches actually have migraines. Furthermore, the downstream effect of the cytokine cascade initiated in migraine physiology can cause rhinologic symptoms, including rhinorrhea, congestion, and lacrimation, which may also confound diagnosis...
January 1, 2018: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/29282046/evaluation-of-pharmacodynamic-properties-and-safety-of-cinnamomum-zeylanicum-ceylon-cinnamon-in-healthy-adults-a-phase-i-clinical-trial
#13
Priyanga Ranasinghe, Ranil Jayawardena, Shehani Pigera, Wasundara Sevwandi Wathurapatha, Hasitha Dhananjaya Weeratunga, G A Sirimal Premakumara, Prasad Katulanda, Godwin Roger Constantine, Priyadarshani Galappaththy
BACKGROUND: Cinnamon is considered as a treatment for many ailments in native medicine. Evidence suggests that Cinnamomum zeylanicum (CZ) has anti-microbial, anti-parasitic, anti-oxidant, blood glucose lowering properties and beneficial cardiovascular effects. The present study aims to evaluate Pharmacodynamic properties and safety of CZ in healthy adults using a Phase I Clinical Trial. METHODS: This phase I clinical trial was conducted at the Department of Pharmacology, Faculty of Medicine, University of Colombo, Sri Lanka...
December 28, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29247248/electrical-semiconduction-modulated-by-light-in-a-cobalt-and-naphthalene-diimide-metal-organic-framework
#14
Evandro Castaldelli, K D G Imalka Jayawardena, David C Cox, Guy J Clarkson, Richard I Walton, Long Le-Quang, Jerôme Chauvin, S Ravi P Silva, Grégoire Jean-François Demets
Metal-organic frameworks (MOFs) have emerged as an exciting class of porous materials that can be structurally designed by choosing particular components according to desired applications. Despite the wide interest in and many potential applications of MOFs, such as in gas storage, catalysis, sensing and drug delivery, electrical semiconductivity and its control is still rare. The use and fabrication of electronic devices with MOF-based components has not been widely explored, despite significant progress of these components made in recent years...
December 15, 2017: Nature Communications
https://www.readbyqxmd.com/read/29180594/referrers-point-of-view-on-the-referral-process-to-neurosurgery-and-opinions-on-neurosurgeons-a-large-scale-regional-survey-in-the-uk
#15
Meriem Amarouche, Jonathan J Neville, Simon Deacon, Nida Kalyal, Nikita Adams, Beverly Cheserem, Daniel Curley, Ruth-Mary DeSouza, Fehmi Hafiz, Tanya Jayawardena, Nishi Khetani, Diana Matthews, Sophie Mustoe, Sabrina Okafor, Olivia Padfield, Ishani Rao, Reem Samir, Hyder Tahir, Benjamin Varghese, Christos Michael Tolias
OBJECTIVES: There is an increased reliance on online referral systems (ORS) within neurosurgical departments across the UK. Opinions of neurosurgeons on ORS are extensively reported but those of referrers have hardly been sought. Our study aims at ascertaining our referring colleagues' views on our ORS and its impact on patient care, their opinions on neurosurgeons and how to improve our referral process. SETTING: 14 district general hospitals and one teaching hospital...
November 26, 2017: BMJ Open
https://www.readbyqxmd.com/read/29145822/ultrasonographic-parameters-of-the-liver-spleen-and-kidneys-among-a-cohort-of-school-children-in-sri-lanka
#16
Dianne Tania Dayanthi Warnakulasuriya, Pattiya Pathirennahalage Uddika Chamila Peries, Yaddehi Arachchillage Chaminda Rathnasekara, KaluArachchige Thushari Madurika Jayawardena, Angappulige Upasena, Anada Rajitha Wickremasinghe
BACKGROUND: Liver, spleen and kidney dimensions on ultrasonography vary with the age, weight and ethnicity. Reference standards of these parameters for normal Sri Lankan children are not available. Our aim was to establish normative data for longitudinal length of liver, spleen and kidneys in healthy children. METHOD: Three hundred fifty-seven children, 5-13 years of age were selected from two randomly selected schools in the Gampaha district in the western province of Sri Lanka...
November 16, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/29136286/brompheniramine-and-chlorpheniramine-pharmacokinetics-following-single-dose-oral-administration-in-children-aged-2-to-17-years
#17
Sudam Pathirana, Shyamalie Jayawardena, Suzanne Meeves, Gary A Thompson
Two pediatric studies characterized brompheniramine and chlorpheniramine pharmacokinetics in a total of 72 subjects, aged 2 to 17 years. A single age-/weight-based oral dose, ranging from 1 to 4 mg, was administered with 2 to 6 oz of water at least 2 hours after a light breakfast. Plasma samples were obtained before and for 72 hours after dosing and analyzed using high-pressure liquid chromatography-tandem mass spectrometry. Pharmacokinetic parameters were estimated using noncompartmental methods; relationships with age were assessed using linear regression...
November 14, 2017: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29072815/zinc-supplementation-in-prediabetes-a-randomized-double-blind-placebo-controlled-clinical-trial
#18
Priyanga Ranasinghe, Wasundara S Wathurapatha, Priyadarshani Galappatthy, Prasad Katulanda, Ranil Jayawardena, Godwin R Constantine
BACKGROUND: This study evaluated the effects of zinc supplementation on glycemic control, other cardiometabolic and anthropometric parameters, and disease progression in prediabetes. METHODS: A randomized double-blind placebo-controlled Phase 2 clinical trial was conducted over a 12-month period in 200 subjects (43% male; mean [± SD] age 51.8 ± 7.3 years), randomly assigned (1:  1) to the treatment or control group. The treatment group received zinc (20 mg daily)...
May 2018: Journal of Diabetes
https://www.readbyqxmd.com/read/29055625/coronary-artery-calcium-progression-is-associated-with-coronary-plaque-volume-progression-results-from-a-quantitative-semiautomated-coronary-artery-plaque-analysis
#19
Indre Ceponiene, Rine Nakanishi, Kazuhiro Osawa, Mitsuru Kanisawa, Negin Nezarat, Sina Rahmani, Kendall Kissel, Michael Kim, Eranthi Jayawardena, Alexander Broersen, Pieter Kitslaar, Matthew J Budoff
OBJECTIVES: The aim of this study was to determine whether coronary artery calcium (CAC) progression was associated with coronary plaque progression on coronary computed tomographic angiography. BACKGROUND: CAC progression and coronary plaque characteristics are associated with incident coronary heart disease. However, natural history of coronary atherosclerosis has not been well described to date, and the understanding of the association between CAC progression and coronary plaque subtypes such as noncalcified plaque progression remains unclear...
October 14, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29036669/comparative-genome-and-transcriptome-analyses-reveal-adaptations-to-opportunistic-infections-in-woody-plant-degrading-pathogens-of-botryosphaeriaceae
#20
Ji Ye Yan, Wen Sheng Zhao, Zhen Chen, Qi Kai Xing, Wei Zhang, K W Thilini Chethana, Min Feng Xue, Jian Ping Xu, Alan J L Phillips, Yong Wang, Jian Hua Liu, Mei Liu, Ying Zhou, Ruvishika S Jayawardena, Ishara S Manawasinghe, Jin Bao Huang, Guang Hang Qiao, Chun Yuan Fu, Fei Fei Guo, Asha J Dissanayake, You Liang Peng, Kevin D Hyde, Xing Hong Li
Botryosphaeriaceae are an important fungal family that cause woody plant diseases worldwide. Recent studies have established a correlation between environmental factors and disease expression; however, less is known about factors that trigger these diseases. The current study reports on the 43.3 Mb de novo genome of Lasiodiplodia theobromae and five other genomes of Botryosphaeriaceae pathogens. Botryosphaeriaceous genomes showed an expansion of gene families associated with cell wall degradation, nutrient uptake, secondary metabolism and membrane transport, which contribute to adaptations for wood degradation...
October 3, 2017: DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes
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