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Stanislaw Klek, Michael Chourdakis, Dima Abdulqudos Abosaleh, Alejandra Amestoy, Hyun Wook Baik, Gertrudis Baptista, Rocco Barazzoni, Ryoji Fukushima, Josef Hartono, Ranil Jayawardena, Rafael Jimenez Garcia, Zeljko Krznaric, Ibolya Nyulasi, Gabriela Parallada, Eliza Mei Perez Francisco, Marina Panisic-Sekeljic, Mario Perman, Arina Prins, Isabel Martinez Del Rio Requejo, Ravinder Reddy, Pierre Singer, Marianna Sioson, Andrew Ukleja, Carla Vartanian, Nicolas Velasco Fuentes, Dan Linetzky Waitzberg, Steve Leonce Zoungrana, Aleksander Galas
BACKGROUND AND OBJECTIVES: Protein-energy and micronutrient malnutrition are global public health problems which, when not prevented and severe, require medical management by clinicians with nutrition expertise, preferably as a collectively skilled team, especially when disease-related. This study aimed to investigate barriers and facilitators of clinical nutrition services (CNS), especially the use of oral, enteral (EN) and parenteral (PN) nutrition in institutional and home settings...
March 2017: Asia Pacific Journal of Clinical Nutrition
Harry M Cronin, K D G Imalka Jayawardena, Zlatka Stoeva, Maxim Shkunov, S Ravi P Silva
Mixed halide Perovskite solar cells (PSCs) are commonly produced by depositing PbCl2 and CH3NH3I from a common solvent followed by thermal annealing, which in an up-scaled manufacturing process is likely to take place under ambient conditions. However, it has been reported that, similar to the effects of thermal annealing, ambient humidity also affects the crystallisation behaviour and subsequent growth of the Perovskite films. This implies that both of these factors must be accounted for in solar cell production...
January 25, 2017: Nanotechnology
P Ranasinghe, Y Mathangasinghe, R Jayawardena, A P Hills, A Misra
BACKGROUND: The Asia-Pacific region is home to nearly half of the world's population. The region has seen a recent rapid increase in the prevalence of obesity, type-2 diabetes and cardiovascular disease. The present systematic review summarizes the recent prevalence and trends of Metabolic Syndrome (MetS) among adults in countries of the Asia-Pacific Region. METHODS: Data on MetS in Asia-Pacific countries were obtained using a stepwise process by searching the online Medline database using MeSH terms 'Metabolic Syndrome X' and 'Epidemiology/EP'...
January 21, 2017: BMC Public Health
Chandra Herath, Chantha Jayawardena, Nandani Nagarathne, Kanthi Perera
AIM: In the present study, we investigated the characteristics and sequelae of erupted supernumerary teeth (ST) in a sample of Sri Lankan children. METHODS: Data were recorded from patients' clinical records, radiographs, models, and extracted teeth. RESULTS: The sample consisted of 239 ST from 218 patients. The mean age of the sample was 9.08 ± 2.47 years. The male-to-female ratio was 2.8:1. The majority (42.66%) of patients with ST were in aged 8-10 years...
December 19, 2016: Journal of Investigative and Clinical Dentistry
Yanzhen Li, Sophie Dal-Pra, Maria Mirotsou, Tilanthi M Jayawardena, Conrad P Hodgkinson, Nenad Bursac, Victor J Dzau
We have recently shown that a combination of microRNAs, miR combo, can directly reprogram cardiac fibroblasts into functional cardiomyocytes in vitro and in vivo. Reprogramming of cardiac fibroblasts by miR combo in vivo is associated with improved cardiac function following myocardial infarction. However, the efficiency of direct reprogramming in vitro is relatively modest and new strategies beyond the traditional two-dimensional (2D) culture should be identified to improve reprogramming process. Here, we report that a tissue-engineered three-dimensional (3D) hydrogel environment enhanced miR combo reprogramming of neonatal cardiac and tail-tip fibroblasts...
December 12, 2016: Scientific Reports
Dileepa M Jayawardena, Scott A Heckathorn, Deepesh R Bista, Sasmita Mishra, Jennifer K Boldt, Charles R Krause
Atmospheric CO2 enrichment is expected to often benefit plant growth, despite causing global warming and nitrogen (N) dilution in plants. Most plants primarily procure N as inorganic nitrate (NO3(-) ) or ammonium (NH4(+) ), using membrane-localized transport proteins in roots, which are key targets for improving N use. Although interactive effects of elevated CO2 , chronic warming and N form on N relations are expected, these have not been studied. In this study, tomato (Solanum lycopersicum) plants were grown at two levels of CO2 (400 or 700 ppm) and two temperature regimes (30 or 37°C), with NO3(-) or NH4(+) as the N source...
March 2017: Physiologia Plantarum
T R Pozegic, J V Anguita, I Hamerton, K D G I Jayawardena, J-S Chen, V Stolojan, P Ballocchi, R Walsh, S R P Silva
Carbon fibre reinforced polymers (CFRP) were introduced to the aerospace, automobile and civil engineering industries for their high strength and low weight. A key feature of CFRP is the polymer sizing - a coating applied to the surface of the carbon fibres to assist handling, improve the interfacial adhesion between fibre and polymer matrix and allow this matrix to wet-out the carbon fibres. In this paper, we introduce an alternative material to the polymer sizing, namely carbon nanotubes (CNTs) on the carbon fibres, which in addition imparts electrical and thermal functionality...
November 23, 2016: Scientific Reports
Shyamalie Jayawardena, David Kellstein
Two blinded single-dose studies randomized children 6 months to 11 years old with fever to receive ibuprofen (IBU) pediatric suspension 7.5 mg/kg or acetaminophen (APAP) suspension 10 to 15 mg/kg. The primary efficacy parameter was time-weighted sum of temperature differences (TWSTD) from baseline through 8 hours for each study. Secondary end points included TWSTD from baseline through 6 hours, time to onset and duration of temperature control, and proportion with temperature control. Studies were pooled for post hoc analyses of efficacy and adverse event end points...
November 20, 2016: Clinical Pediatrics
Kumari M Rathnayake, Kdrr Silva, Ranil Jayawardena
BACKGROUND: The prevalence of obesity is escalating alarmingly worldwide, and it is now becoming a rapidly growing epidemic in developing countries. Recent studies have reported that zinc has been implicated in altered lipid markers, insulin resistance and some obesity markers. There is a lack of evidence on zinc as a potential therapeutic agent to reduce weight and improve metabolic parameters in obese adults. The present study is designed to evaluate the effects of zinc supplementation on obese adults in Sri Lanka...
November 4, 2016: Trials
Daisuke Ueno, Takashi Kurokawa, Katsuichiro Maruo, Tsuneaki Watanabe, Jayanetti Asiri Jayawardena
INTRODUCTION: Perforation of the Schneiderian membrane is the most common complication in sinus floor augmentation (SFA). When volume of grafting is qualified to prevent enlargement of the membrane perforation, lack of bone volume may occur in optimal site. CASE PRESENTATION: SFA was performed in sites #24 to 26 in a 63-year-old male. However, a 10-mm size perforation of the Schneiderian membrane occurred in site #26. Although the sinus cavity was grafted with deproteinized bovine bone mineral (DBBM) after repair of membrane perforation, insufficient bone formation was observed on palatal and distal aspects of site #26 at 5 months after SFA...
December 2015: International Journal of Implant Dentistry
Daisuke Ueno, Jayanetti Asiri Jayawardena, Takashi Kurokawa
Soft tissue dehiscence around dental implant has frequently been observed and it may lead to poor oral hygiene, especially around crowns that exhibit contours with prominent convexity. The present case demonstrates a peri-implant mucosal dehiscence coverage with modified semilunar coronary positioned flap (CPF) in #15 and 16. A semilunar partial-thickness incision was performed 7-10 mm apical from the facial gingival margin. Then, intrasulcular partial-thickness incision was tunneled to the semilunar incision...
December 2015: International Journal of Implant Dentistry
Ravini Jayawardena, Heather Winskel
The current study aimed to test the applicability of the modified receptive field (MRF) theory (Tydgat & Grainger, 2009) with English native speakers (Experiment 1) and Sinhalese native speakers (Experiment 2), who were skilled readers of both Sinhala and Roman scripts. A two-alternative forced choice (2AFC) procedure to measure identification accuracy for all positions in a string of five characters, which consisted of Roman script letters, Sinhala letters or symbols was conducted. For Roman script, the English and Sinhalese speakers displayed analogous results as in previous studies for Roman letters and symbols (i...
November 2016: Acta Psychologica
Arivarasu N Anbazhagan, Mentor Thaqi, Shubha Priyamvada, Dulari Jayawardena, Anoop Kumar, Tarunmeet Gujral, Ishita Chatterjee, Edurne Mugarza, Seema Saksena, Hayat Onyuksel, Pradeep K Dudeja
The gut hormone, glucagon like peptide-1 (GLP-1) exerts anti-inflammatory effects. However, its clinical use is limited by its short half-life. Previously, we have shown that GLP-1 as a nanomedicine (GLP-1 in sterically stabilized phospholipid micelles, GLP-1-SSM) has increased in vivo stability. The current study was aimed at testing the efficacy of this GLP-1 nanomedicine in alleviating colonic inflammation and associated diarrhea in dextran sodium sulfate (DSS) induced mouse colitis model. Our results show that GLP-1-SSM treatment markedly alleviated the colitis phenotype by reducing the expression of pro-inflammatory cytokine IL-1β, increasing goblet cells and preserving intestinal epithelial architecture in colitis model...
August 20, 2016: Nanomedicine: Nanotechnology, Biology, and Medicine
Steven Christensen, Ed Paluch, Shyamalie Jayawardena, Stephen Daniels, Suzanne Meeves
Analgesic effects of ibuprofen immediate-release/extended-release (IR/ER) 600 mg tablets were evaluated in 2 randomized, double-blind, placebo-controlled dental pain studies. Patients 16-40 years old with moderate-severe pain following third molar extraction received single-dose ibuprofen 600 mg IR/ER (formulation A or B), naproxen sodium 220 mg, or placebo (2:2:2:1) (Study 1) or 4 doses of ibuprofen 600 mg IR/ER (formulation A) or placebo (1:1) (Study 2). In Study 1 (N = 196), mean (standard deviation [SD]) time-weighted sum of pain intensity difference scores for placebo, ibuprofen IR/ER A, ibuprofen IR/ER B, and naproxen, respectively, were 0...
August 22, 2016: Clinical Pharmacology in Drug Development
Ranil Jayawardena, Priyanga Ranasinghe, Maheshi Wijayabandara, Andrew P Hills, Anoop Misra
Introduction Obesity among teenagers/adolescents and young adults is associated with significant adverse short and longer-term effects on health. To date, no narrative reviews have evaluated nutrition transition and its contribution to the obesity epidemic among adolescents and young adults in the South Asian (SA) region. Methods Data were retrieved by a four-stage systematic search process. A search of the online PubMed/Medline, SciVerse Scopus and Web of Science databases was performed. The age groups were defined as follows; teenage:13-19 years, adolescence:10-18 years and young adult:19-24 years...
August 8, 2016: Current Diabetes Reviews
Martina Réblová, Andrew N Miller, Amy Y Rossman, Keith A Seifert, Pedro W Crous, David L Hawksworth, Mohamed A Abdel-Wahab, Paul F Cannon, Dinushani A Daranagama, Z Wilhelm De Beer, Shi-Ke Huang, Kevin D Hyde, Ruvvishika Jayawardena, Walter Jaklitsch, E B Gareth Jones, Yu-Ming Ju, Caroline Judith, Sajeewa S N Maharachchikumbura, Ka-Lai Pang, Liliane E Petrini, Huzefa A Raja, Andrea I Romero, Carol Shearer, Indunil C Senanayake, Hermann Voglmayr, Bevan S Weir, Nalin N Wijayawarden
With the advance to one scientific name for each fungal species, the generic names in the class Sordariomycetes typified by sexual and asexual morphs are evaluated based on their type species to determine if they compete with each other for use or protection. Recommendations are made for which of the competing generic names should be used based on criteria such as priority, number of potential names changes, and frequency of use. Some recommendations for well-known genera include Arthrinium over Apiospora, Colletotrichum over Glomerella, Menispora over Zignoëlla, Microdochium over Monographella, Nigrospora over Khuskia, and Plectosphaerella over Plectosporium...
June 2016: IMA Fungus
Ranil Jayawardena, Pavani Punchihewa, Ishara Ranathunga, Niroshan Lokunarangoda, Anidu Keerthi Pathirana, Wijeyasingam Samuel Santharaj
BACKGROUND: Misperception of body weight by individuals is a known occurrence. However, it is a potential target for implementing obesity reduction interventions in patients with cardiovascular and metabolic diseases. The aim of this study was to describe the association between self-perception of body weight and objectively measured body mass index (BMI) among cardiac patients in a specialist cardiology institution in Sri Lanka. METHOD: During the study period, 322 (61 %) males and 204 (39 %) females were recruited from consecutive admissions to the Institute of Cardiology, National Hospital, Colombo, Sri Lanka...
2016: BMC Obesity
Thomas Legg, Edward Paluch, Shyamalie Jayawardena
A single-dose, randomized, open-label, crossover study (study 1; n = 35) and a multiple-dose, randomized, open-label, crossover study (study 2; n = 28) compared the pharmacokinetics of a new immediate-release/extended-release (IR/ER) bilayer tablet formulation of ibuprofen 600 mg every 12 hours with standard ibuprofen 200 mg IR every 4 hours. In both studies, the 2 formulations were bioequivalent to each other for the area under the plasma concentration-versus-time curve from time 0 to the last measurable concentration (AUCL), to infinity (AUC∞ ), and to 12 hours (AUC0-12 ) and maximum concentration (Cmax )...
January 2017: Clinical Pharmacology in Drug Development
Uthpala A Jayawardena, Wanigasekara D Ratnasooriya, Deepthi D Wickramasinghe, Preethi V Udagama
Immune cell and cytokine profiles in relation to metal exposure though much studied in mammals has not been adequately investigated in amphibians, due mainly to lack of suitable reagents for cytokine profiling in non-model species. However, interspecies cross reactivity of cytokines permitted us to assay levels of IFNγ, TNFα, IL6 and IL10in a common anuran, the Indian green frog (Euphlyctis hexadactylus), exposed to heavy metals (Cd, Cr, Cu, Zn and Pb, at ~5ppm each) under field and laboratory settings in Sri Lanka...
October 1, 2016: Science of the Total Environment
Xuan Chen, Bin Wu, Kalana W Jayawardana, Nanjing Hao, H Surangi N Jayawardena, Robert Langer, Ana Jaklenec, Mingdi Yan
A multivalent trehalose-grafted poly(lactic acid) is synthesized and encapsulated with iron oxide magnetic nanoparticles. The magnetic micelles interact with Mycobacterium smegmatis to form orange clusters. Very little particle interaction is found on Staphylococcus epidermidis 35984 or Escherichia coli ORN 208. The presented new approach to the detection of mycobacteria does not require molecular biology reagents or sophisticated instruments.
August 2016: Advanced Healthcare Materials
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