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Daisuke Ueno, Takashi Kurokawa, Katsuichiro Maruo, Tsuneaki Watanabe, Jayanetti Asiri Jayawardena
INTRODUCTION: Perforation of the Schneiderian membrane is the most common complication in sinus floor augmentation (SFA). When volume of grafting is qualified to prevent enlargement of the membrane perforation, lack of bone volume may occur in optimal site. CASE PRESENTATION: SFA was performed in sites #24 to 26 in a 63-year-old male. However, a 10-mm size perforation of the Schneiderian membrane occurred in site #26. Although the sinus cavity was grafted with deproteinized bovine bone mineral (DBBM) after repair of membrane perforation, insufficient bone formation was observed on palatal and distal aspects of site #26 at 5 months after SFA...
December 2015: Int J Implant Dent
Daisuke Ueno, Jayanetti Asiri Jayawardena, Takashi Kurokawa
Soft tissue dehiscence around dental implant has frequently been observed and it may lead to poor oral hygiene, especially around crowns that exhibit contours with prominent convexity. The present case demonstrates a peri-implant mucosal dehiscence coverage with modified semilunar coronary positioned flap (CPF) in #15 and 16. A semilunar partial-thickness incision was performed 7-10 mm apical from the facial gingival margin. Then, intrasulcular partial-thickness incision was tunneled to the semilunar incision...
December 2015: Int J Implant Dent
Ravini Jayawardena, Heather Winskel
The current study aimed to test the applicability of the modified receptive field (MRF) theory (Tydgat & Grainger, 2009) with English native speakers (Experiment 1) and Sinhalese native speakers (Experiment 2), who were skilled readers of both Sinhala and Roman scripts. A two-alternative forced choice (2AFC) procedure to measure identification accuracy for all positions in a string of five characters, which consisted of Roman script letters, Sinhala letters or symbols was conducted. For Roman script, the English and Sinhalese speakers displayed analogous results as in previous studies for Roman letters and symbols (i...
September 23, 2016: Acta Psychologica
Arivarasu N Anbazhagan, Mentor Thaqi, Shubha Priyamvada, Dulari Jayawardena, Anoop Kumar, Tarunmeet Gujral, Ishita Chatterjee, Edurne Mugarza, Seema Saksena, Hayat Onyuksel, Pradeep K Dudeja
The gut hormone, Glucagon like peptide-1 (GLP-1) exerts anti-inflammatory effects. However, its clinical use is limited by its short half-life. Previously, we have shown that GLP-1 as a nanomedicine (GLP-1 in sterically stabilized phospholipid micelles, GLP-1-SSM) has increased in vivo stability. The current study was aimed at testing the efficacy of this GLP-1 nanomedicine in alleviating colonic inflammation and associated diarrhea in dextran sodium sulfate (DSS) induced mouse colitis model. Our results show that GLP-1-SSM treatment markedly alleviated the colitis phenotype by reducing the expression of pro-inflammatory cytokine IL-1β, increasing goblet cells and preserving intestinal epithelial architecture in colitis model...
August 20, 2016: Nanomedicine: Nanotechnology, Biology, and Medicine
Steven Christensen, Ed Paluch, Shyamalie Jayawardena, Stephen Daniels, Suzanne Meeves
Analgesic effects of ibuprofen immediate-release/extended-release (IR/ER) 600 mg tablets were evaluated in 2 randomized, double-blind, placebo-controlled dental pain studies. Patients 16-40 years old with moderate-severe pain following third molar extraction received single-dose ibuprofen 600 mg IR/ER (formulation A or B), naproxen sodium 220 mg, or placebo (2:2:2:1) (Study 1) or 4 doses of ibuprofen 600 mg IR/ER (formulation A) or placebo (1:1) (Study 2). In Study 1 (N = 196), mean (standard deviation [SD]) time-weighted sum of pain intensity difference scores for placebo, ibuprofen IR/ER A, ibuprofen IR/ER B, and naproxen, respectively, were 0...
August 22, 2016: Clinical Pharmacology in Drug Development
Ranil Jayawardena, Priyanga Ranasinghe, Maheshi Wijayabandara, Andrew P Hills, Anoop Misra
Introduction Obesity among teenagers/adolescents and young adults is associated with significant adverse short and longer-term effects on health. To date, no narrative reviews have evaluated nutrition transition and its contribution to the obesity epidemic among adolescents and young adults in the South Asian (SA) region. Methods Data were retrieved by a four-stage systematic search process. A search of the online PubMed/Medline, SciVerse Scopus and Web of Science databases was performed. The age groups were defined as follows; teenage:13-19 years, adolescence:10-18 years and young adult:19-24 years...
August 8, 2016: Current Diabetes Reviews
Martina Réblová, Andrew N Miller, Amy Y Rossman, Keith A Seifert, Pedro W Crous, David L Hawksworth, Mohamed A Abdel-Wahab, Paul F Cannon, Dinushani A Daranagama, Z Wilhelm De Beer, Shi-Ke Huang, Kevin D Hyde, Ruvvishika Jayawardena, Walter Jaklitsch, E B Gareth Jones, Yu-Ming Ju, Caroline Judith, Sajeewa S N Maharachchikumbura, Ka-Lai Pang, Liliane E Petrini, Huzefa A Raja, Andrea I Romero, Carol Shearer, Indunil C Senanayake, Hermann Voglmayr, Bevan S Weir, Nalin N Wijayawarden
With the advance to one scientific name for each fungal species, the generic names in the class Sordariomycetes typified by sexual and asexual morphs are evaluated based on their type species to determine if they compete with each other for use or protection. Recommendations are made for which of the competing generic names should be used based on criteria such as priority, number of potential names changes, and frequency of use. Some recommendations for well-known genera include Arthrinium over Apiospora, Colletotrichum over Glomerella, Menispora over Zignoëlla, Microdochium over Monographella, Nigrospora over Khuskia, and Plectosphaerella over Plectosporium...
June 2016: IMA Fungus
Ranil Jayawardena, Pavani Punchihewa, Ishara Ranathunga, Niroshan Lokunarangoda, Anidu Keerthi Pathirana, Wijeyasingam Samuel Santharaj
BACKGROUND: Misperception of body weight by individuals is a known occurrence. However, it is a potential target for implementing obesity reduction interventions in patients with cardiovascular and metabolic diseases. The aim of this study was to describe the association between self-perception of body weight and objectively measured body mass index (BMI) among cardiac patients in a specialist cardiology institution in Sri Lanka. METHOD: During the study period, 322 (61 %) males and 204 (39 %) females were recruited from consecutive admissions to the Institute of Cardiology, National Hospital, Colombo, Sri Lanka...
2016: BMC Obesity
Thomas Legg, Edward Paluch, Shyamalie Jayawardena
A single-dose, randomized, open-label, crossover study (Study 1; N = 35) and a multiple-dose, randomized, open-label, crossover study (Study 2; N = 28) compared the pharmacokinetics of a new immediate-release/extended-release (IR/ER) bilayer tablet formulation of ibuprofen 600 mg q12h with standard ibuprofen 200 mg IR q4h. In both studies, the 2 formulations were bioequivalent to each other for the area under the plasma concentration vs time curve from time 0 to the last measurable concentration (AUCL), to infinity (AUC∞ ), and to 12 hours (AUC0-12 ) and maximum concentration (Cmax )...
July 1, 2016: Clinical Pharmacology in Drug Development
Uthpala A Jayawardena, Wanigasekara D Ratnasooriya, Deepthi D Wickramasinghe, Preethi V Udagama
Immune cell and cytokine profiles in relation to metal exposure though much studied in mammals has not been adequately investigated in amphibians, due mainly to lack of suitable reagents for cytokine profiling in non-model species. However, interspecies cross reactivity of cytokines permitted us to assay levels of IFNγ, TNFα, IL6 and IL10in a common anuran, the Indian green frog (Euphlyctis hexadactylus), exposed to heavy metals (Cd, Cr, Cu, Zn and Pb, at ~5ppm each) under field and laboratory settings in Sri Lanka...
October 1, 2016: Science of the Total Environment
Xuan Chen, Bin Wu, Kalana W Jayawardana, Nanjing Hao, H Surangi N Jayawardena, Robert Langer, Ana Jaklenec, Mingdi Yan
A multivalent trehalose-grafted poly(lactic acid) is synthesized and encapsulated with iron oxide magnetic nanoparticles. The magnetic micelles interact with Mycobacterium smegmatis to form orange clusters. Very little particle interaction is found on Staphylococcus epidermidis 35984 or Escherichia coli ORN 208. The presented new approach to the detection of mycobacteria does not require molecular biology reagents or sophisticated instruments.
August 2016: Advanced Healthcare Materials
Edward Paluch, Shyamalie Jayawardena, Brenda Wilson, Sarah Farnsworth
OBJECTIVE: The extent to which people comply with labeled instructions for use of long-acting over-the-counter analgesics is largely unknown; this study evaluated whether consumers can correctly select and use a new long-acting ibuprofen 600-mg immediate-release and extended-release (IR/ER) product. DESIGN: A single open-label study with participants randomly assigned to 2 substudies. Self-selection substudy: participants estimated duration of their last pain episode, then selected ibuprofen IR/ER or standard ibuprofen IR for a similar episode...
July 2016: Journal of the American Pharmacists Association: JAPhA
Ranil Jayawardena, Nuala M Byrne, Mario J Soares, Prasad Katulanda, Andrew P Hills
Sri Lanka is undergoing nutritional transition and diet-related chronic diseases are emerging as an important health problem. Currently, no validated food frequency questionnaire (FFQ) exists to measure habitual dietary intake of Sri Lankan adults. The purpose of the study is to assess the validity of a semi-quantitative FFQ and 7-day weighed-intake dietary records (7DWR), designed to assess dietary intake among Sri Lankan adults. Dietary intake was measured using both a FFQ and 7DWR. The FFQ consisted of 8 food groups containing the main foods comprising the diet of Sri Lankan adults, a total of 85 items and 12 color photographs to identify serving size...
2016: SpringerPlus
Gary G Kay, Howard I Schwartz, Mark A Wingertzahn, Shyamalie Jayawardena, Russell P Rosenberg
OBJECTIVE: Next-day residual effects of a nighttime dose of gabapentin 250 mg were evaluated on simulated driving performance in healthy participants in a randomized, placebo-controlled, double-blind, multicenter, four-period crossover study that included diphenhydramine citrate 76 mg and triazolam 0.5 mg. METHODS: At treatment visits, participants (n = 59) were dosed at ~23:30, went to bed immediately, and awakened 6.5 h postdose for evaluation. The primary endpoint was the standard deviation of lateral position for the 100-km driving scenario...
May 2016: Human Psychopharmacology
Yan Zhang, H Surangi N Jayawardena, Mingdi Yan, Olof Ramström
A complex dynamic hemithioacetal system was generated for the evaluation of lipase reactivities in organic media. In combination with pattern recognition methodology, twelve different lipases were successfully classified into four distinct groups following their reaction selectivities and reactivities. A probe lipase was further categorized using the training matrix with predicted reactivity.
April 11, 2016: Chemical Communications: Chem Comm
Uthpala A Jayawardena, Jason R Rohr, Ayanthi N Navaratne, Priyanie H Amerasinghe, Rupika S Rajakaruna
The impact of widespread and common environmental factors, such as chemical contaminants, on infectious disease risk in amphibians is particularly important because both chemical contaminants and infectious disease have been implicated in worldwide amphibian declines. Here we report on the lone and combined effects of exposure to parasitic cercariae (larval stage) of the digenetic trematode, Acanthostomum burminis, and four commonly used pesticides (insecticides: chlorpyrifos, dimethoate; herbicides: glyphosate, propanil) at ecologically relevant concentrations on the survival, growth, and development of the common hourglass tree frog, Polypedates cruciger Blyth 1852...
March 2016: EcoHealth
Nilakshi Jayawardena, Mindani I Watawana, Ruchini T Jayathilaka, Viduranga Y Waisundara
The antioxidant and starch hydrolase inhibitory activities of cardamom, cloves, coriander, cumin seeds, curry leaves, fenugreek, mustard seeds, nutmeg, sweet cumin, and star anise extracts were investigated in an in vitro model of digestion mimicking the gastric and duodenal conditions. The total phenolic contents in all spice extracts had statistically significantly (P < 0.05) increased following both gastric and duodenal digestion. This was also in correlation with the antioxidant assays quantifying the water-soluble antioxidant capacity of the extracts...
2015: Evidence-based Complementary and Alternative Medicine: ECAM
Madanodaya Sundhoro, Hui Wang, Scott T Boiko, Xuan Chen, H Surangi N Jayawardena, JaeHyeung Park, Mingdi Yan
We report the fabrication of carbohydrate microarrays on a photoactive polymer, poly(HEMA-co-HEMA-PFPA), synthesized by RAFT copolymerization of 2-hydroxyethyl methacrylate (HEMA) and perfluorophenyl azide (PFPA)-derivatized HEMA (HEMA-PFPA). PFPA allows the covalent immobilization of carbohydrates whereas the HEMA polymer provides an antifouling surface, thus the microarrays can be used directly without pretreating the array with a blocking agent. The microarrays were prepared by spin-coating the polymer followed by printing the carbohydrates...
January 21, 2016: Organic & Biomolecular Chemistry
Kathryn Peri, Ngaire Kerse, Elizabeth Broadbent, Chandimal Jayawardena, Tony Kuo, Chandan Datta, Rebecca Stafford, Bruce MacDonald
AIMS: To investigate whether robots could reduce resident sleeping and stimulate activity in the lounges of an older persons' care facility. METHODS: Non-randomised controlled trial over a 12-week period. The intervention involved situating robots in low-level and high-dependency ward lounges and a comparison with similar lounges without robots. A time sampling observation method was utilised to observe resident behaviour, including sleep and activities over periods of time, to compare interactions in robot and no robot lounges...
March 2016: Australasian Journal on Ageing
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