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https://www.readbyqxmd.com/read/28865957/zinc-binds-non-cooperatively-to-human-liver-metallothionein-2a-at-physiological-ph
#1
Devika P Jayawardena, Ilka U Heinemann, Martin J Stillman
Maintenance of the homeostasis of zinc is very important in regulating bodily functions. There are over 300 Zn-dependent enzymes identified where Zn(II) plays a structural or catalytic role. However, an excess of Zn(II) in a cell is toxic and free Zn(II) is tightly controlled. Metallothioneins (MTs) are small cysteine rich proteins that can bind up to seven Zn(II) and act as a Zn(II) reservoir. The MT2a isoform is predominantly found in the liver. This study focused on designing an MT2a construct of recombinant human MT2a to determine the Zn(II) binding profile of MT2a in vitro...
August 30, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28777120/multicenter-aids-cohort-study-quantitative-coronary-plaque-progression-study-rationale-and-design
#2
Rine Nakanishi, Wendy S Post, Kazuhiro Osawa, Eranthi Jayawardena, Michael Kim, Nasim Sheidaee, Negin Nezarat, Sina Rahmani, Nicholas Kim, Nicolai Hathiramani, Shriraj Susarla, Frank Palella, Mallory Witt, Michael J Blaha, Todd T Brown, Lawrence Kingsley, Sabina A Haberlen, Christopher Dailing, Matthew J Budoff
BACKGROUND AND AIM: The association of HIV with coronary atherosclerosis has been established; however, the progression of coronary atherosclerosis over time among participants with HIV is not well known. The Multicenter AIDS Cohort Study Quantitative Coronary Plaque Progression Study is a large prospective multicenter study quantifying progression of coronary plaque assessed by serial coronary computed tomography angiography (CTA). PATIENTS AND METHODS: HIV-infected and uninfected men who were enrolled in the Multicenter AIDS Cohort Study Cardiovascular Substudy were eligible to complete a follow-up contrast coronary CTA 3-6 years after baseline...
August 2, 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/28693601/effects-of-the-plate-model-as-part-of-dietary-intervention-on-modification-of-selected-cardiometabolic-risk-factors-in-post-myocardial-infarction-patients-study-protocol-for-a-randomized-controlled-trial
#3
Ranil Jayawardena, Pasindu Fernando, Niroshan Lokunarangoda, Anidu Keerthi Pathirana
BACKGROUND: Cardiovascular disease remains the leading cause of morbidity and mortality worldwide, and there is a rising global burden. The effects of diet on cardiometabolic risk factors have been studied extensively. Healthy eating as a cost-effective approach to risk reduction in post-myocardial infarction patients is proven to be beneficial, and the "plate model" is one of the practical methods to achieve this objective. METHODS/DESIGN: The study will be conducted as a randomized, single-blind, controlled clinical trial for a period of 3 months...
July 10, 2017: Trials
https://www.readbyqxmd.com/read/28663602/genera-of-phytopathogenic-fungi-gophy-1
#4
Y Marin-Felix, J Z Groenewald, L Cai, Q Chen, S Marincowitz, I Barnes, K Bensch, U Braun, E Camporesi, U Damm, Z W de Beer, A Dissanayake, J Edwards, A Giraldo, M Hernández-Restrepo, K D Hyde, R S Jayawardena, L Lombard, J Luangsa-Ard, A R McTaggart, A Y Rossman, M Sandoval-Denis, M Shen, R G Shivas, Y P Tan, E J van der Linde, M J Wingfield, A R Wood, J Q Zhang, Y Zhang, P W Crous
Genera of Phytopathogenic Fungi (GOPHY) is introduced as a new series of publications in order to provide a stable platform for the taxonomy of phytopathogenic fungi. This first paper focuses on 21 genera of phytopathogenic fungi: Bipolaris, Boeremia, Calonectria, Ceratocystis, Cladosporium, Colletotrichum, Coniella, Curvularia, Monilinia, Neofabraea, Neofusicoccum, Pilidium, Pleiochaeta, Plenodomus, Protostegia, Pseudopyricularia, Puccinia, Saccharata, Thyrostroma, Venturia and Wilsonomyces. For each genus, a morphological description and information about its pathology, distribution, hosts and disease symptoms are provided...
March 2017: Studies in Mycology
https://www.readbyqxmd.com/read/28568743/interventions-for-treatment-and-or-prevention-of-alcohol-hangover-systematic-review
#5
REVIEW
Ranil Jayawardena, Thulasika Thejani, Priyanga Ranasinghe, Dinithi Fernando, Joris C Verster
OBJECTIVE: To evaluate new research conducted over the past few years (2009-2016) assessing the effectiveness of potentially curative and/or preventive methods of alcohol hangover. METHODS: Data were retrieved by a 4-stage systematic search process. A search of the online Pubmed and Scopus databases were performed, using a combination of keywords: "Alcohol," "Ethanol," and "C2 H5 OH," in combination with the terms "Hangover," "Treatment," and "Prevention." The search comprised studies listed between January 1, 2009 and June 30, 2016...
May 31, 2017: Human Psychopharmacology
https://www.readbyqxmd.com/read/28474750/heavy-metal-induced-toxicity-in-the-indian-green-frog-biochemical-and-histopathological-alterations
#6
Uthpala Apekshani Jayawardena, Preethika Angunawela, Deepthi Devika Wickramasinghe, Wanigasekara Daya Ratnasooriya, Preethi Vidya Udagama
Heavy metal contamination may have adverse effects on wetland biota, particularly on amphibians. Severe immunotoxic effects elicited in Euphlyctis hexadactylus (Indian green frog) because of metal exposure (Cd, Cr, Cu, Pb, and Zn) in the Bellanwila-Attidiya Sanctuary, a polluted urban wetland in Sri Lanka, provided the rationale for the present study. We evaluated the biochemical and histopathological effects of this metal contamination with a reference E. hexadactylus population and a laboratory exposure group that was subjected to 28 d of exposure to a mixture of Cd, Cr, Cu, Pb, and Zn (5 ppm in each mixture)...
May 5, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/28446195/mature-leaf-concentrate-of-sri-lankan-wild-type-carica-papaya-linn-modulates-nonfunctional-and-functional-immune-responses-of-rats
#7
Chanika Dilumi Jayasinghe, Dinara S Gunasekera, Nuwan De Silva, Kithmini Kawya Mandakini Jayawardena, Preethi Vidya Udagama
BACKGROUND: The leaf concentrate of Carica papaya is a traditionally acclaimed immunomodulatory remedy against numerous diseases; nonetheless comprehensive scientific validation of this claim is limited. The present study thus investigated the immunomodulatory potential of Carica papaya mature leaf concentrate (MLCC) of the Sri Lankan wild type cultivar using nonfunctional and functional immunological assays. METHODS: Wistar rats (N = 6/ group) were orally gavaged with 3 doses (0...
April 26, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28403141/vamp3-syb-and-ykt6-are-required-for-the-fusion-of-constitutive-secretory-carriers-with-the-plasma-membrane
#8
David E Gordon, Joanne Chia, Kamburpola Jayawardena, Robin Antrobus, Frederic Bard, Andrew A Peden
The cellular machinery required for the fusion of constitutive secretory vesicles with the plasma membrane in metazoans remains poorly defined. To address this problem we have developed a powerful, quantitative assay for measuring secretion and used it in combination with combinatorial gene depletion studies in Drosophila cells. This has allowed us to identify at least three SNARE complexes mediating Golgi to PM transport (STX1, SNAP24/29 and Syb; STX1, SNAP24/29 and YKT6; STX4, SNAP24 and Syb). RNAi mediated depletion of YKT6 and VAMP3 in mammalian cells also blocks constitutive secretion suggesting that YKT6 has an evolutionarily conserved role in this process...
April 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28400040/a-comparison-of-rescue-and-primary-percutaneous-coronary-interventions-for-acute-st-elevation-myocardial-infarction
#9
M B Faslur Rahuman, Jayanthimala B Jayawardena, George R Francis, Niraj Mahboob, Wasantha Kumara A H T, Aruna Wijesinghe, Rashan Haniffa, Ranithrie Ariyapperuma, Abbyramy Paramanayakam, Pubudu A De Silva
OBJECTIVE: To perform a comparative analysis of in-hospital results obtained from patients with acute ST elevation myocardial infarction (STEMI), who underwent rescue or primary percutaneous coronary intervention (PCI). The aim is to determine rescue PCI as a practical option for patients with no immediate access to primary PCI. METHODS: From the Cardiology PCI Clinic of the National Hospital of Sri Lanka (NHSL), we selected all consecutive patients presenting with acute STEMI </=24h door-to-balloon delay for primary PCI and </=72h door-to-balloon delay, (90min after failed thrombolysis) for rescue PCI, from March 2013 to April 2015 and their in-hospital results were analyzed, comparing rescue and primary PCI patients...
April 2017: Indian Heart Journal
https://www.readbyqxmd.com/read/28398221/amyloid-fibrils-from-hemoglobin
#10
Nadishka Jayawardena, Manmeet Kaur, Smitha Nair, Jenny Malmstrom, David Goldstone, Leonardo Negron, Juliet A Gerrard, Laura J Domigan
Amyloid fibrils are a class of insoluble protein nanofibers that are formed via the self-assembly of a wide range of peptides and proteins. They are increasingly exploited for a broad range of applications in bionanotechnology, such as biosensing and drug delivery, as nanowires, hydrogels, and thin films. Amyloid fibrils have been prepared from many proteins, but there has been no definitive characterization of amyloid fibrils from hemoglobin to date. Here, nanofiber formation was carried out under denaturing conditions using solutions of apo-hemoglobin extracted from bovine waste blood...
April 11, 2017: Biomolecules
https://www.readbyqxmd.com/read/28395159/poly-hema-co-hema-pfpa-synthesis-and-preparation-of-stable-micelles-encapsulating-imaging-nanoparticles
#11
Madanodaya Sundhoro, Jaehyeung Park, Kalana W Jayawardana, Xuan Chen, H Surangi N Jayawardena, Mingdi Yan
We report the preparation of stable micelles from random copolymers of 2-hydroxyethyl methacrylate (HEMA) and perfluorophenyl azide (PFPA)-derivatized HEMA (HEMA-PFPA). The copolymers were synthesized by RAFT polymerization at room temperature under mild conditions without affecting the azide functionality. Upon addition of water to the copolymer solution in DMSO, the random copolymers self-assembled into micelles even at the percentage of HEMA-PFPA as low as 4.5%. The size of the micelles can be controlled by the molecular weight and the concentration of the copolymer, and the percentage of HEMA-PFPA in the copolymer...
March 24, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28385693/expression-and-localization-of-vpac1-the-major-receptor-of-vasoactive-intestinal-peptide-along-the-length-of-the-intestine
#12
Dulari Jayawardena, Grace Guzman, Ravinder K Gill, Waddah A Alrefai, Hayat Onyuksel, Pradeep K Dudeja
Vasoactive intestinal peptide (VIP) is an endogenous neuropeptide with a broad array of physiological functions in many organs including the intestine. Its actions are mediated via G protein-coupled receptors, and vasoactive intestinal peptide receptor 1 (VPAC1) is the key receptor responsible for majority of VIP's biological activity. The distribution of VPAC1 along the length of the gastrointestinal tract and its subcellular localization in intestinal epithelial cells have not been fully characterized. The current studies were undertaken to determine VPAC1 distribution and localization so that VIP-based therapies can be targeted to specific regions of the intestine...
July 1, 2017: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/28244702/health-insurance-or-subsidy-has-universal-advantage-for-management-of-hospital-malnutrition-unrelated-to-gdp
#13
COMPARATIVE STUDY
Stanislaw Klek, Michael Chourdakis, Dima Abdulqudos Abosaleh, Alejandra Amestoy, Hyun Wook Baik, Gertrudis Baptista, Rocco Barazzoni, Ryoji Fukushima, Josef Hartono, Ranil Jayawardena, Rafael Jimenez Garcia, Zeljko Krznaric, Ibolya Nyulasi, Gabriela Parallada, Eliza Mei Perez Francisco, Marina Panisic-Sekeljic, Mario Perman, Arina Prins, Isabel Martinez Del Rio Requejo, Ravinder Reddy, Pierre Singer, Marianna Sioson, Andrew Ukleja, Carla Vartanian, Nicolas Velasco Fuentes, Dan Linetzky Waitzberg, Steve Leonce Zoungrana, Aleksander Galas
BACKGROUND AND OBJECTIVES: Protein-energy and micronutrient malnutrition are global public health problems which, when not prevented and severe, require medical management by clinicians with nutrition expertise, preferably as a collectively skilled team, especially when disease-related. This study aimed to investigate barriers and facilitators of clinical nutrition services (CNS), especially the use of oral, enteral (EN) and parenteral (PN) nutrition in institutional and home settings...
March 2017: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28119511/effects-of-ambient-humidity-on-the-optimum-annealing-time-of-mixed-halide-perovskite-solar-cells
#14
Harry M Cronin, K D G Imalka Jayawardena, Zlatka Stoeva, Maxim Shkunov, S Ravi P Silva
Mixed halide Perovskite solar cells (PSCs) are commonly produced by depositing PbCl2 and CH3NH3I from a common solvent followed by thermal annealing, which in an up-scaled manufacturing process is likely to take place under ambient conditions. However, it has been reported that, similar to the effects of thermal annealing, ambient humidity also affects the crystallisation behaviour and subsequent growth of the Perovskite films. This implies that both of these factors must be accounted for in solar cell production...
January 25, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28109251/prevalence-and-trends-of-metabolic-syndrome-among-adults-in-the-asia-pacific-region-a-systematic-review
#15
REVIEW
P Ranasinghe, Y Mathangasinghe, R Jayawardena, A P Hills, A Misra
BACKGROUND: The Asia-Pacific region is home to nearly half of the world's population. The region has seen a recent rapid increase in the prevalence of obesity, type-2 diabetes and cardiovascular disease. The present systematic review summarizes the recent prevalence and trends of Metabolic Syndrome (MetS) among adults in countries of the Asia-Pacific Region. METHODS: Data on MetS in Asia-Pacific countries were obtained using a stepwise process by searching the online Medline database using MeSH terms 'Metabolic Syndrome X' and 'Epidemiology/EP'...
January 21, 2017: BMC Public Health
https://www.readbyqxmd.com/read/27990766/characteristics-and-sequelae-of-erupted-supernumerary-teeth-a-study-of-218-cases-among-sri-lankan-children
#16
Chandra Herath, Chantha Jayawardena, Nandani Nagarathne, Kanthi Perera
AIM: In the present study, we investigated the characteristics and sequelae of erupted supernumerary teeth (ST) in a sample of Sri Lankan children. METHODS: Data were recorded from patients' clinical records, radiographs, models, and extracted teeth. RESULTS: The sample consisted of 239 ST from 218 patients. The mean age of the sample was 9.08 ± 2.47 years. The male-to-female ratio was 2.8:1. The majority (42.66%) of patients with ST were in aged 8-10 years...
December 19, 2016: Journal of Investigative and Clinical Dentistry
https://www.readbyqxmd.com/read/27941896/tissue-engineered-3-dimensional-3d-microenvironment-enhances-the-direct-reprogramming-of-fibroblasts-into-cardiomyocytes-by-micrornas
#17
Yanzhen Li, Sophie Dal-Pra, Maria Mirotsou, Tilanthi M Jayawardena, Conrad P Hodgkinson, Nenad Bursac, Victor J Dzau
We have recently shown that a combination of microRNAs, miR combo, can directly reprogram cardiac fibroblasts into functional cardiomyocytes in vitro and in vivo. Reprogramming of cardiac fibroblasts by miR combo in vivo is associated with improved cardiac function following myocardial infarction. However, the efficiency of direct reprogramming in vitro is relatively modest and new strategies beyond the traditional two-dimensional (2D) culture should be identified to improve reprogramming process. Here, we report that a tissue-engineered three-dimensional (3D) hydrogel environment enhanced miR combo reprogramming of neonatal cardiac and tail-tip fibroblasts...
December 12, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27893161/elevated-co2-plus-chronic-warming-reduce-nitrogen-uptake-and-levels-or-activities-of-nitrogen-uptake-and-assimilatory-proteins-in-tomato-roots
#18
Dileepa M Jayawardena, Scott A Heckathorn, Deepesh R Bista, Sasmita Mishra, Jennifer K Boldt, Charles R Krause
Atmospheric CO2 enrichment is expected to often benefit plant growth, despite causing global warming and nitrogen (N) dilution in plants. Most plants primarily procure N as inorganic nitrate (NO3(-) ) or ammonium (NH4(+) ), using membrane-localized transport proteins in roots, which are key targets for improving N use. Although interactive effects of elevated CO2 , chronic warming and N form on N relations are expected, these have not been studied. In this study, tomato (Solanum lycopersicum) plants were grown at two levels of CO2 (400 or 700 ppm) and two temperature regimes (30 or 37°C), with NO3(-) or NH4(+) as the N source...
March 2017: Physiologia Plantarum
https://www.readbyqxmd.com/read/27876858/multi-functional-carbon-fibre-composites-using-carbon-nanotubes-as-an-alternative-to-polymer-sizing
#19
T R Pozegic, J V Anguita, I Hamerton, K D G I Jayawardena, J-S Chen, V Stolojan, P Ballocchi, R Walsh, S R P Silva
Carbon fibre reinforced polymers (CFRP) were introduced to the aerospace, automobile and civil engineering industries for their high strength and low weight. A key feature of CFRP is the polymer sizing - a coating applied to the surface of the carbon fibres to assist handling, improve the interfacial adhesion between fibre and polymer matrix and allow this matrix to wet-out the carbon fibres. In this paper, we introduce an alternative material to the polymer sizing, namely carbon nanotubes (CNTs) on the carbon fibres, which in addition imparts electrical and thermal functionality...
November 23, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27872357/antipyretic-efficacy-and-safety-of-ibuprofen-versus-acetaminophen-suspension-in-febrile-children-results-of-2-randomized-double-blind-single-dose-studies
#20
Shyamalie Jayawardena, David Kellstein
Two blinded single-dose studies randomized children 6 months to 11 years old with fever to receive ibuprofen (IBU) pediatric suspension 7.5 mg/kg or acetaminophen (APAP) suspension 10 to 15 mg/kg. The primary efficacy parameter was time-weighted sum of temperature differences (TWSTD) from baseline through 8 hours for each study. Secondary end points included TWSTD from baseline through 6 hours, time to onset and duration of temperature control, and proportion with temperature control. Studies were pooled for post hoc analyses of efficacy and adverse event end points...
November 20, 2016: Clinical Pediatrics
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