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https://www.readbyqxmd.com/read/29909229/functional-evaluation-of-bilateral-subtalar-arthroereisis-for-the-correction-of-flexible-flatfoot-in-children-1-year-follow-up
#1
Paolo Caravaggi, Giada Lullini, Lisa Berti, Sandro Giannini, Alberto Leardini
BACKGROUND: Flexible flatfoot (FFF) is a common alteration of the foot diagnosed in the pediatric population causing pain and decreased quality of life. Surgical treatment via arthroereisis of the subtalar joint can be recommended when non-invasive options do not result in sufficient pain relief. While clinical outcome of subtalar joint arthroereisis is generally positive, no functional evaluation has thus far been reported following surgery. RESEARCH QUESTION: The aim of this study was to assess the effects of two arthroereisis implants for the correction of bilateral FFF on foot and lower limb biomechanics during gait...
June 11, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29896876/estimating-the-uncertainty-of-calculated-out-of-field-organ-dose-from-a-commercial-treatment-planning-system
#2
Lilie Wang, George X Ding
Therapeutic radiation to cancer patients is accompanied by unintended radiation to organs outside the treatment field. It is known that the model-based dose algorithm has limitation in calculating the out-of-field doses. This study evaluated the out-of-field dose calculated by the Varian Eclipse treatment planning system (v.11 with AAA algorithm) in realistic treatment plans with the goal of estimating the uncertainties of calculated organ doses. Photon beam phase-space files for TrueBeam linear accelerator were provided by Varian...
June 12, 2018: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/29884021/core-shell-corona-micelles-from-a-polyether-based-triblock-terpolymer-investigation-of-the-ph-dependent-micellar-structure
#3
Shotaro Miwa, Rintaro Takahashi, Carsten Rossel, Sakiko Matsumoto, Shota Fujii, Ji Ha Lee, Felix H Schacher, Kazuo Sakurai
Core-shell-corona micelles featuring a pH-responsive shell have been characterized in dilute aqueous solution at different pH values (= 4-8) by using field-flow fractionation coupled with multi-angle light scattering detector (FFF-MALS), steady-state fluorescence, and small-angle X-ray scattering (SAXS). The micelles are formed by self-assembly of a polyether-based triblock terpolymer consisting of a hydrophobic poly( tert-butyl glycidyl ether) block (P tBGE), a pH-responsive modified poly(allyl glycidyl ether) segment (PAGECOOH ), and a neutral hydrophilic poly(ethylene oxide) block (PEO)...
June 8, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29866334/photon-dose-at-the-maze-entrance-door-the-comparison-of-flattening-filter-and-flattening-filter-free-working-modes
#4
Á Á Tóth, L D Dragojlović, N V Ignjatov, M Krmar
In recent years, field flattening free accelerators have been introduced in therapy practice. One of the objective of these measurements was to establish if the maze door, designed for accelerators operating with flattening filter can provide adequate shielding in field flattening free mode of operation. Linac installed in this standard one band maze vault is equipped to operate at 6 MV with field flattening filter and in field flattening free mode of operation. Series of measurements of the photon dose at the maze door (with different jaws openings and gantry positions) were performed in both operation modes with and without water canister to mimic standard therapy conditions...
May 2018: Physica Medica: PM
https://www.readbyqxmd.com/read/29850845/radiobiological-effects-of-flattening-filter-free-photon-beams-on-a549-non-small-cell-lung-cancer-cells
#5
Hisashi Nakano, Kazumasa Minami, Masashi Yagi, Hiromasa Imaizumi, Yuki Otani, Shinichi Inoue, Masaaki Takashina, Yuji Seo, Yutaka Takahashi, Iori Sumida, Kazuhiko Ogawa, Masahiko Koizumi
Flattening filter-free (FFF) photon beams minimize the intrafraction motion of tumors, and this feature is useful in pulmonary malignancies, such as non-small-cell lung cancer (NSCLC). However, the radiobiological effects of such beams on NSCLC cells, which are often treated with stereotactic body radiotherapy (SBRT), have not been investigated sufficiently. Although cell motility may be promoted by photon beams with a low dose, the relationship between cell motility and the dose rate of photon beams has not been evaluated...
May 30, 2018: Journal of Radiation Research
https://www.readbyqxmd.com/read/29785729/tg-51-reference-dosimetry-for-the-halcyon%C3%A2-a-clinical-experience
#6
Samantha A M Lloyd, Tze Yee Lim, Xenia Fave, Everardo Flores-Martinez, Todd F Atwood, Vitali Moiseenko
Halcyon™ is a single-energy (6 MV-FFF), bore-enclosed linear accelerator. Patient setup is performed by first aligning to external lasers mounted to the front of the bore, and then loading to isocenter through pre-defined couch shifts. There is no light field, optical distance indicator or front pointer mechanism, so positioning is verified through MV imaging with kV imaging scheduled to become available in the future. TG-51 reference dosimetry was successfully performed for Halcyon™ in this imaging-based setup paradigm...
May 21, 2018: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/29781165/dose-rate-response-of-digital-megavolt-imager-detector-for-flattening-filter-free-beams
#7
Zhigang Xu, Jinkoo Kim, James Han, An Ting Hsia, Samuel Ryu
In this study we investigated the dose rate response characteristics of the Digital Megavolt Imager (DMI) detector, including panel saturation, linearity, and imager ghosting effects for flattening filter-free (FFF) beams. The DMI detector dose rate response characteristics were measured as a function of dose rate on a Varian TrueBeam machine. Images were acquired at dose rates ranging from 400 to 1400 MU/min for 6XFFF and 400 to 2400 MU/min for 10XFFF. Line profiles and central portal doses derived from the images were analyzed and compared...
May 21, 2018: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/29780047/-evaluation-of-a-2d-diode-array-corresponding-to-flattening-filter-free-x-ray-beams
#8
Tomoko Kimura, Jun-Ichi Fukunaga, Taka-Aki Hirose, Ryota Hirayama
Recently, a medical linear accelerator with a flattening filter free (FFF) mode has led to the use of FFF X-ray beams at clinical sites. The usefulness of FFF X-ray beams in high-precision radiation therapy has been reported. Therefore, the quality assurance and quality control for FFF X-ray beams have become necessary. In this study, the characteristics of the detectors of a newly developed 2-D diode array (MapCHECK2, Sun Nuclear Corporation) for FFF X-ray beams, i.e., dose reproducibility, dose rate dependence, dose linearity, and output factor, were evaluated...
2018: Nihon Hoshasen Gijutsu Gakkai Zasshi
https://www.readbyqxmd.com/read/29736714/discovery-of-modulators-of-adipocyte-physiology-using-fully-functionalized-fragments
#9
Andrea Galmozzi, Christopher G Parker, Bernard P Kok, Benjamin F Cravatt, Enrique Saez
Defects in adipocyte function associated with obesity drive the development of systemic insulin resistance and type 2 diabetes. Agents that correct obesity-linked adipocyte dysfunction serve as useful insulin sensitizers in humans, as is exemplified by the thiazolidinediones (TZDs). We have developed a new platform that integrates advanced chemoproteomics with phenotypic screening to identify small molecules that promote differentiation and lipid storage in adipocytes, and, in tandem, their molecular target(s)...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29731290/feasibility-study-for-combination-of-field-flow-fractionation-fff-based-separation-of-size-coded-particle-probes-with-amplified-surface-enhanced-raman-scattering-sers-tagging-for-simultaneous-detection-of-multiple-mirnas
#10
Kayeong Shin, Jaeyeong Choi, Yeoju Kim, Yoonjeong Lee, Joohoon Kim, Seungho Lee, Hoeil Chung
We propose a new analytical scheme in which field-flow fractionation (FFF)-based separation of target-specific polystyrene (PS) particle probes of different sizes are incorporated with amplified surface-enhanced Raman scattering (SERS) tagging for the simultaneous and sensitive detection of multiple microRNAs (miRNAs). For multiplexed detection, PS particles of three different diameters (15, 10, 5 μm) were used for the size-coding, and a probe single stranded DNA (ssDNA) complementary to a target miRNA was conjugated on an intended PS particle...
April 27, 2018: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29725053/u-s-agro-climate-in-20-th-century-growing-degree-days-first-and-last-frost-growing-season-length-and-impacts-on-crop-yields
#11
Meetpal S Kukal, Suat Irmak
Significant air temperature changes have occurred globally during the 20th century, which are spatially variable to a considerable degree and these changes can have substantial implications in agroecosystem productivity. The agroclimate indicators that are responsible in these contexts are first fall frost (FFF), last spring frost (LSF), climatological growing season (CGS) length, and heat accumulation (growing degree days, GDD). We explore spatial and temporal trends associated with these indices across the continental U...
May 3, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29713642/patient-specific-surgical-implants-made-of-3d-printed-peek-material-technology-and-scope-of-surgical-application
#12
Philipp Honigmann, Neha Sharma, Brando Okolo, Uwe Popp, Bilal Msallem, Florian M Thieringer
Additive manufacturing (AM) is rapidly gaining acceptance in the healthcare sector. Three-dimensional (3D) virtual surgical planning, fabrication of anatomical models, and patient-specific implants (PSI) are well-established processes in the surgical fields. Polyetheretherketone (PEEK) has been used, mainly in the reconstructive surgeries as a reliable alternative to other alloplastic materials for the fabrication of PSI. Recently, it has become possible to fabricate PEEK PSI with Fused Filament Fabrication (FFF) technology...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29696321/linac-based-stereotactic-body-radiation-therapy-for-unresectable-locally-advanced-pancreatic-cancer-risk-adapted-dose-prescription-and-image-guided-delivery
#13
Rosario Mazzola, Sergio Fersino, Dario Aiello, Fabiana Gregucci, Umberto Tebano, Stefanie Corradini, Gioacchino Di Paola, Massimo Cirillo, Luca Tondulli, Giacomo Ruffo, Ruggero Ruggieri, Filippo Alongi
BACKGROUND: Stereotactic body radiation therapy (SBRT) represents a new treatment option for locally advanced pancreatic cancer (LAPC). An accurate treatment planning with risk-adapted dose prescription with adherence to specific dose constraints for organs at risk (OARs) and the use of daily cone beam CT (CBCT) for image guidance could allow an effective and safe treatment delivery. Here, feasibility and efficacy of SBRT in LAPC treated in our cancer care center are reported. PATIENTS AND METHODS: 33 unresectable LAPC patients underwent SBRT...
April 25, 2018: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/29671410/motion-induced-interplay-effects-for-vmat-radiotherapy
#14
Anneli Edvardsson, Fredrik Nordström, Crister Ceberg, Sofie Ceberg
The purpose of this study was to develop a method to simulate breathing motion induced interplay effects for volumetric modulated arc therapy (VMAT), to verify the proposed method with measurements, and to use the method to investigate how interplay effects vary with different patient- and machine specific parameters. VMAT treatment plans were created on a virtual phantom in a treatment planning system (TPS). Interplay effects were simulated by dividing each plan into smaller sub-arcs using an in-house developed software and shifting the isocenter for each sub-arc to simulate a sin6 breathing motion in the superior-inferior direction...
April 19, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29580032/comparative-evaluation-of-a-6mv-flattened-beam-and-a-flattening-filter-free-beam-for-carcinoma-of-cervix-%C3%A2-imrt-planning-study
#15
Suresh Tamilarasu, Madeswaran Saminathan, S K Sharma, Anjali Pahuja, Abhinav Dewan
Purpose: Intensity modulated radiotherapy (IMRT) plan quality, beam on time and integral dose were compared using 6MV FB (Flattened Beam) and FFFB (Flattening filter free beam) for carcinoma of cervix. Materials and Methods: Ten patients with stage II–IIIB cervix cancer (Ca.Cx) were retrospectively identified from the department database. Target volume (TV) and organ at risk (OAR) were delineated as per Radiation Therapy Oncology Group (RTOG) cancer guidelines. Dose prescribed to planning target volume (PTV) was 50...
March 27, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29563993/flattening-filter-free-technique-in-volumetric-modulated-arc-therapy-for-lung-stereotactic-body-radiotherapy-a-clinical-comparison-with-the-flattening-filter-technique
#16
Shuri Aoki, Hideomi Yamashita, Akihiro Haga, Kanabu Nawa, Toshikazu Imae, Wataru Takahashi, Osamu Abe, Keiichi Nakagawa
The present study sought to evaluate the impact of the flattening filter-free (FFF) technique in volumetric modulated arc therapy for lung stereotactic body radiotherapy. Its clinical safety and availability were compared with the flattening filter (FF) method. The cases of 65 patients who underwent lung volumetric modulated arc therapy-stereotactic body radiotherapy (VMAT-SBRT) using FF or FFF techniques were reviewed. A total of 55 Gy/4 fractions (fr) was prescribed for peripheral lesions or 56 Gy/7 fr for central lesions...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29562568/monte-carlo-evaluation-of-the-potential-benefits-of-flattening-filter-free-beams-from-the-oncor%C3%A2-clinical-linear-accelerator
#17
Amin Asadi, Seid Kazem Razavi-Ratki, Keyvan Jabbari, Milad Najafzadeh, Abolfazl Nickfarjam
OBJECTIVES: To evaluate the potential privileges of flattening filter-free (FFF) photon beams from Oncor® linac for 6 MV and 18 MV energies. METHODS: A Monte Carlo (MC) model of Oncor® linac was built using BEAMnrc MCCode and verified by the measured data using 6 MV and 18 MV energies. A comprehensive set of data was also characterized for MC model of Oncor® machine running with and without flattening filter (FF) for 6 MV and 18 MV beams in six field sizes...
2018: Journal of X-ray Science and Technology
https://www.readbyqxmd.com/read/29558116/structural-polymorphism-in-a-self-assembled-tri-aromatic-peptide-system
#18
Noam Brown, Jiangtao Lei, Chendi Zhan, Linda J W Shimon, Lihi Adler-Abramovich, Guanghong Wei, Ehud Gazit
Self-assembly is a process of key importance in natural systems and in nanotechnology. Peptides are attractive building blocks due to their relative facile synthesis, biocompatibility, and other unique properties. Diphenylalanine (FF) and its derivatives are known to form nanostructures of various architectures and interesting and varied characteristics. The larger triphenylalanine peptide (FFF) was found to self-assemble as efficiently as FF, forming related but distinct architectures of plate-like and spherical nanostructures...
April 24, 2018: ACS Nano
https://www.readbyqxmd.com/read/29543930/evaluation-of-two-3d-printers-for-guided-implant-surgery
#19
Bruno Sommacal, Miodrag Savic, Andreas Filippi, Sebastian Kühl, Florian M Thieringer
PURPOSE: To compare the suitability of a fused filament fabrication (FFF) consumer 3D printer with a professional digital light processing (DLP) printer for the production of surgical templates for guided oral implant surgery. MATERIALS AND METHODS: Eight virtual templates were printed with two different 3D printers. These were optically scanned and the incongruences between virtual and printed templates were determined after alignment of the surface scans and the virtual data...
March 15, 2018: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/29528650/reproducing-quantum-probability-distributions-at-the-speed-of-classical-dynamics-a-new-approach-for-developing-force-field-functors
#20
Vikram Sundar, David Gelbwaser-Klimovsky, Alán Aspuru-Guzik
Modeling nuclear quantum effects is required for accurate molecular dynamics (MD) simulations of molecules. The community has paid special attention to water and other biomolecules that show hydrogen bonding. Standard methods of modeling nuclear quantum effects like Ring Polymer Molecular Dynamics (RPMD) are computationally costlier than running classical trajectories. A force-field functor (FFF) is an alternative method that computes an effective force field that replicates quantum properties of the original force field...
April 5, 2018: Journal of Physical Chemistry Letters
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