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https://www.readbyqxmd.com/read/29138099/effect-of-an-antimicrobial-stewardship-programme-on-antimicrobial-utilisation-and-costs-in-patients-with-leukaemia-a-retrospective-interventional-controlled-study
#1
Miranda So, Muhammad Mamdani, Andrew Morris, Tim Lau, Raewyn Broady, Uday Deotare, Jennifer Grant, Dennis Dong Hwan Kim, Aaron D Schimmer, Andre Schuh, Salomeh Shajari, Marilyn Steinberg, Chaim M Bell, Shahid Husain
OBJECTIVES: To examine the effectiveness of an antimicrobial stewardship programme (ASPs) on utilisation and cost of antimicrobials in leukaemia patients in Canada. METHODS: We conducted a multisite, retrospective, observational time-series study from 2005 to 2013. We implemented academic detailing as the intervention of an ASP in leukaemia units at a hospital, piloted February-July 2010, then fully implemented December 2010-March 2013, with no intervention in August-November 2010...
November 11, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29136617/prognostic-factors-in-patients-with-an-implanted-pacemaker-after-80-years-of-age-in-a-4-year-follow-up
#2
Krystyna Krzemień-Wolska, Andrzej Tomasik, Celina Wojciechowska, Karolina Barańska-Pawełczak, Ewa Nowalany-Kozielska, Wojciech Jacheć
BACKGROUND: The controversy over electrotherapy for patients aged >80 years occurs already at the stage of qualification for this treatment type and concerns optimal device selection, the implantation strategy, and the overall benefit from pacemaker therapy. The group also has a considerable number of cardiovascular risk factors, and the data from the literature on the impact of the pacing mode on the remote prognosis of this group are ambiguous. OBJECTIVE: Assessment of the risk factors for death among patients with implanted pacemakers >80 years of age in a 4-year follow-up...
November 15, 2017: Gerontology
https://www.readbyqxmd.com/read/29136593/polycyclic-aromatic-hydrocarbons-and-organochlorine-pesticides-in-surface-water-from-the-yongding-river-basin-china-seasonal-distribution-source-apportionment-and-potential-risk-assessment
#3
Yizhen Wang, Shilu Zhang, Wenyan Cui, Xianzhi Meng, Xianqiang Tang
The presence of 17 polycyclic aromatic hydrocarbons (PAHs) and 15 persistent organochlorine pesticides (OCPs) in surface water of the Yongding River Basin was analyzed through GC/MS/MS during the spring and summer at 46 sampling sites. The goal was to investigate their seasonal distribution, possible sources, and potential risk. Our results showed that the total PAH concentration in surface water of Yongding River Basin ranged from 41.60 to 1482.60ng/L with a mean value of 137.85ng/L in the spring, and from 53...
November 11, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29131997/organochlorine-pesticides-across-the-tributaries-of-river-ravi-pakistan-human-health-risk-assessment-through-dermal-exposure-ecological-risks-source-fingerprints-and-spatio-temporal-distribution
#4
Mujtaba Baqar, Yumna Sadef, Sajid Rashid Ahmad, Adeel Mahmood, Jun Li, Gan Zhang
This study monitored the human health risks through dermal exposure, hazardous risks to ecological integrity, contamination levels, spatio-temporal distribution, and congener specific analysis of organochlorine pesticides (OCPs) across River Ravi and its three northern tributaries (Nullah Bein, Nullah Basanter and Nullah Deg). The residual levels of OCPs isomers were screened for water (n=54) and surface sediment (n=54) samples from twenty seven sampling sites in two alternate seasons (pre-monsoon and post-monsoon)...
November 10, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29131410/primary-antibiotic-resistance-of-helicobacter-pylori-strains-among-adults-and-children-in-a-tertiary-referral-centre-in-lithuania
#5
Gintare Dargiene, Juozas Kupcinskas, Laimas Jonaitis, Mindaugas Vezbavicius, Edmundas Kadusevicius, Eugenija Kupcinskiene, Tove Havnhoj Frandsen, Ruta Kucinskiene, Limas Kupcinskas, Leif Percival Andersen
The study evaluated primary antibiotic resistance of Helicobacter pylori within the period 2013-2015 and trends of antibiotic consumption over the last decade in Lithuania; 242 adults and 55 children were included in the study. E-tests were performed for amoxicillin, metronidazole, clarithromycin, ciprofloxacin, rifampicin and tetracycline. The presence of H. pylori and clarithromycin resistance was additionally tested by PCR. Helicobacter pylori culture was positive in 67 of 242 (28%) adult and in 12 of 55 (21...
November 13, 2017: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/29131294/clinical-echocardiographic-and-pacing-parameters-affecting-atrial-fibrillation-burden-in-tachycardia-bradycardia-patients
#6
Jan Bohdan Ciszewski, Tomasz Chwyczko, Ilona Kowalik, Wojciech Majda, Michał Mirosław Farkowski, Agnieszka Jankowska, Anna Borowiec, Paweł Syska, Hanna Szwed, Mariusz Pytkowski
BACKGROUND: The influence of different factors on the atrial fibrillation (AF) development in the population of tachycardia bradycardia syndrome (TBS) patients remains unclear. There is no data examining such an impact of different right ventricular pacing percentage (RVp%) profiles. AIM: The purpose of the study was to evaluate the relationship between the AF burden (AFB) and different clinical, echocardiographic and pacing parameters in TBS patients. METHODS: We performed a prospective, one-year registry of TBS patients with documented AF referred to the dual-chamber pacemaker (DDD) implantation...
November 13, 2017: Kardiologia Polska
https://www.readbyqxmd.com/read/29125004/impact-of-the-automated-dose-dispensing-with-medication-review-on-geriatric-primary-care-patients-drug-use-in-finland-a-nationwide-cohort-study-with-matched-controls
#7
Juha Sinnemäki, Marja Airaksinen, Maria Valaste, Leena K Saastamoinen
OBJECTIVE: In an automated dose dispensing (ADD) service, medicines are dispensed in unit-dose bags according to administration times. When the service is initiated, the patient's medication list is reconciled and a prescription review is conducted. The service is expected to reduce drug use. The aim of this national controlled study was to investigate whether the ADD service with medication review reduces drug use among geriatric primary care patients. DESIGN, SETTING AND PATIENTS: This is a nationwide cohort study with matched controls...
November 10, 2017: Scandinavian Journal of Primary Health Care
https://www.readbyqxmd.com/read/29121960/non-invasive-quantification-of-age-related-changes-in-the-vertebral-endplate-in-rats-using-in-vivo-dce-mri
#8
Hui Li, Jia-Zhi Yan, Yong-Jie Chen, Wei-Bo Kang, Jia-Xi Huang
BACKGROUND: Small animal models that can mimic degenerative disc disease (DDD) are commonly used to examine DDD progression. However, assessments such as histological studies and macroscopic measurements do not allow for longitudinal studies because they can only be completed after the animal is sacrificed. Dynamic contrast-enhanced MRI (DCE-MRI) may provide a reliable, non-invasive in vivo method for detecting the progression. METHODS: The present study investigated the progression of changes in lumbar discs and the effect of endplate conditions on diffusion into the lumbar discs of aging sand rats after intravenous administration of gadolinium-containing contrast medium through the tail vein...
November 9, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29114226/metformin-use-correlates-with-reduced-risk-of-gallstones-in-diabetic-patients-a-12-year-follow-up-study
#9
Kuan-Fu Liao, Hsun-Yang Chuang, Shih-Wei Lai
Objective: Few studies are available on the association between gallstones and metformin use. The objective of the study was to determine whether metformin use is associated with gallstones. Methods: A population-based retrospective cohort study was conducted using the database of the Taiwan National Health Insurance Program. Subjects of newly diagnosed diabetes mellitus were included from 2002 to 2013. The metformin-exposure group was defined as ≥29 cumulative defined daily dose (DDD) of metformin use. The un-exposure group was defined as <29 cumulative DDD of metformin use...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29110398/teaching-targeted-drug-discovery-and-development-to-healthcare-professionals
#10
Renee Fruchter, Meleha Ahmad, Michael Pillinger, Claudia Galeano, Bruce N Cronstein, Gabrielle Gold-von Simson
Drug discovery and development (DDD) is an interdisciplinary enterprise that spans the translational continuum. Despite DDD's importance, formal training within medical and biomedical schools is lacking. In this tutorial, we outline the current educational landscape in DDD and the growing educational need in this area. Lastly, we describe the Health Innovations and Therapeutics concentration as an example of how to design and implement an educational program in DDD. This article is protected by copyright. All rights reserved...
November 7, 2017: Clinical and Translational Science
https://www.readbyqxmd.com/read/29106825/recurrent-de-novo-mutations-disturbing-the-gtp-gdp-binding-pocket-of-rab11b-cause-intellectual-disability-and-a-distinctive-brain-phenotype
#11
Ideke J C Lamers, Margot R F Reijnders, Hanka Venselaar, Alison Kraus, Sandra Jansen, Bert B A de Vries, Gunnar Houge, Gyri Aasland Gradek, Jieun Seo, Murim Choi, Jong-Hee Chae, Ineke van der Burgt, Rolph Pfundt, Stef J F Letteboer, Sylvia E C van Beersum, Simone Dusseljee, Han G Brunner, Dan Doherty, Tjitske Kleefstra, Ronald Roepman
The Rab GTPase family comprises ∼70 GTP-binding proteins, functioning in vesicle formation, transport and fusion. They are activated by a conformational change induced by GTP-binding, allowing interactions with downstream effectors. Here, we report five individuals with two recurrent de novo missense mutations in RAB11B; c.64G>A; p.Val22Met in three individuals and c.202G>A; p.Ala68Thr in two individuals. An overlapping neurodevelopmental phenotype, including severe intellectual disability with absent speech, epilepsy, and hypotonia was observed in all affected individuals...
October 23, 2017: American Journal of Human Genetics
https://www.readbyqxmd.com/read/29100085/de-novo-missense-mutations-in-dhx30-impair-global-translation-and-cause-a-neurodevelopmental-disorder
#12
Davor Lessel, Claudia Schob, Sébastien Küry, Margot R F Reinders, Tamar Harel, Mohammad K Eldomery, Zeynep Coban-Akdemir, Jonas Denecke, Shimon Edvardson, Estelle Colin, Alexander P A Stegmann, Erica H Gerkes, Marine Tessarech, Dominique Bonneau, Magalie Barth, Thomas Besnard, Benjamin Cogné, Anya Revah-Politi, Tim M Strom, Jill A Rosenfeld, Yaping Yang, Jennifer E Posey, LaDonna Immken, Nelly Oundjian, Katherine L Helbig, Naomi Meeks, Kelsey Zegar, Jenny Morton, Jolanda H Schieving, Ana Claasen, Matthew Huentelman, Vinodh Narayanan, Keri Ramsey, Han G Brunner, Orly Elpeleg, Sandra Mercier, Stéphane Bézieau, Christian Kubisch, Tjitske Kleefstra, Stefan Kindler, James R Lupski, Hans-Jürgen Kreienkamp
DHX30 is a member of the family of DExH-box helicases, which use ATP hydrolysis to unwind RNA secondary structures. Here we identified six different de novo missense mutations in DHX30 in twelve unrelated individuals affected by global developmental delay (GDD), intellectual disability (ID), severe speech impairment and gait abnormalities. While four mutations are recurrent, two are unique with one affecting the codon of one recurrent mutation. All amino acid changes are located within highly conserved helicase motifs and were found to either impair ATPase activity or RNA recognition in different in vitro assays...
November 2, 2017: American Journal of Human Genetics
https://www.readbyqxmd.com/read/29099124/variations-in-serum-concentrations-of-selected-organochlorines-among-delivering-women-in-argentina-the-emasar-study
#13
Solrunn Hansen, Evert Nieboer, Natalia Bravo, Inger Økland, Silvinia Matiocevich, Marisa Viviana Alvarez, Stein Tore Nilsen, Joan O Grimalt, Jon Øyvind Odland
The EMASAR study is the first study to describe the body burden of OCs in Argentinian women after delivery. In total, 698 maternal serum samples from Salta (n = 498) and Ushuaia (n = 200) were collected in 2011-2012 and analyzed for a total of 7 polychlorinated biphenyls (PCBs) and 12 pesticide-related compounds. Only 11 of the compounds had detection rates above 60% in one or both places. Compared with Ushuaian women, those from Salta exhibited higher lipid-adjusted concentrations of p,p'-DDE, p,p'-DDT, β-HCH, and PCB 118 (p ≤ 0...
November 3, 2017: Environmental Science. Processes & Impacts
https://www.readbyqxmd.com/read/29097605/pura-syndrome-clinical-delineation-and-genotype-phenotype-study-in-32-individuals-with-review-of-published-literature
#14
Margot R F Reijnders, Robert Janowski, Mohsan Alvi, Jay E Self, Ton J van Essen, Maaike Vreeburg, Rob P W Rouhl, Servi J C Stevens, Alexander P A Stegmann, Jolanda Schieving, Rolph Pfundt, Katinke van Dijk, Eric Smeets, Connie T R M Stumpel, Levinus A Bok, Jan Maarten Cobben, Marc Engelen, Sahar Mansour, Margo Whiteford, Kate E Chandler, Sofia Douzgou, Nicola S Cooper, Ene-Choo Tan, Roger Foo, Angeline H M Lai, Julia Rankin, Andrew Green, Tuula Lönnqvist, Pirjo Isohanni, Shelley Williams, Ilene Ruhoy, Karen S Carvalho, James J Dowling, Dorit L Lev, Katalin Sterbova, Petra Lassuthova, Jana Neupauerová, Jeff L Waugh, Sotirios Keros, Jill Clayton-Smith, Sarah F Smithson, Han G Brunner, Ceciel van Hoeckel, Mel Anderson, Virginia E Clowes, Victoria Mok Siu, The Ddd Study, Paulo Selber, Richard J Leventer, Christoffer Nellaker, Dierk Niessing, David Hunt, Diana Baralle
BACKGROUND: De novo mutations in PURA have recently been described to cause PURA syndrome, a neurodevelopmental disorder characterised by severe intellectual disability (ID), epilepsy, feeding difficulties and neonatal hypotonia. OBJECTIVES: To delineate the clinical spectrum of PURA syndrome and study genotype-phenotype correlations. METHODS: Diagnostic or research-based exome or Sanger sequencing was performed in individuals with ID. We systematically collected clinical and mutation data on newly ascertained PURA syndrome individuals, evaluated data of previously reported individuals and performed a computational analysis of photographs...
November 2, 2017: Journal of Medical Genetics
https://www.readbyqxmd.com/read/29091214/validation-of-adapted-daily-dose-definitions-for-hospital-antibacterial-drug-use-evaluation-a-multicentre-study
#15
Gesche Först, Katja de With, Nadine Weber, Johannes Borde, Christiane Querbach, Johannes Kleideiter, Claudia Seifert, Stefan Hagel, Andreas Ambrosch, Micha Löbermann, Philipp Schröder, Michaela Steib-Bauert, Winfried V Kern
Background: The WHO/ATC (Anatomical Therapeutic Chemical) index DDD (WHO-DDD) is commonly used for drug consumption measurement. Discrepancies between WHO-DDD and actual prescribed daily doses (PDD) in hospitals have prompted alternative dose definitions adapted to doses recommended in hospital practice guidelines [recommended daily doses (RDD)]. Methods: In order to validate RDD we performed modified point prevalence surveys in 24 acute care hospitals and recorded 20620 PDD of antibiotics given to 4226 adult patients on the day of the survey and the 6 preceding days...
October 1, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29091203/has-primary-care-antimicrobial-use-really-been-increasing-comparison-of-changes-in-different-prescribing-measures-for-a-complete-geographic-population-1995-2014
#16
Mark D J Neilly, Bruce Guthrie, Virginia Hernandez Santiago, Thenmalar Vadiveloo, Peter T Donnan, Charis A Marwick
Objectives: To elucidate how population trends in total antimicrobials dispensed in the community translate into individual exposure. Methods: Retrospective, population-based observational study of all antimicrobial prescribing in a Scottish region in financial years 1995, 2000 and 2005-14. Analysis of temporal changes in all antimicrobials and specific antimicrobials measured in: WHO DDD per 1000 population; prescriptions per 1000 population; proportion of population with ≥1 prescription; mean number of prescriptions per person receiving any; mean DDD per prescription...
October 1, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29074562/expanding-the-clinical-spectrum-of-recessive-truncating-mutations-of-klhl7-to-a-bohring-opitz-like-phenotype
#17
Ange-Line Bruel, Stefania Bigoni, Joanna Kennedy, Margo Whiteford, Chris Buxton, Giulia Parmeggiani, Matt Wherlock, Geoff Woodward, Mark Greenslade, Maggie Williams, Judith St-Onge, Alessandra Ferlini, Giampaolo Garani, Elisa Ballardini, Bregje W van Bon, Rocio Acuna-Hidalgo, Axel Bohring, Jean-François Deleuze, Anne Boland, Vincent Meyer, Robert Olaso, Emmanuelle Ginglinger, Ddd Study, Jean-Baptiste Rivière, Han G Brunner, Alexander Hoischen, Ruth Newbury-Ecob, Laurence Faivre, Christel Thauvin-Robinet, Julien Thevenon
BACKGROUND: Bohring-Opitz syndrome (BOS) is a rare genetic disorder characterised by a recognisable craniofacial appearance and a typical 'BOS' posture. BOS is caused by sporadic mutations ofASXL1. However, several typical patients with BOS have no molecular diagnosis, suggesting clinical and genetic heterogeneity. OBJECTIVES: To expand the phenotypical spectrum of autosomal recessive variants of KLHL7, reported as causing Crisponi syndrome/cold-induced sweating syndrome type 1 (CS/CISS1)-like syndrome...
October 26, 2017: Journal of Medical Genetics
https://www.readbyqxmd.com/read/29074297/hierarchical-imbalanced-pro-inflammatory-cytokine-networks-govern-the-pathogenesis-of-chronic-arthropathies
#18
REVIEW
G Livshits, A Kalinkovich
BACKGROUND: Chronic inflammatory arthropathies, such as rheumatoid arthritis (RA), spondyloarthritis, including psoriatic arthritis (PsA), ankylosing spondyloarthritis (AS), osteoarthritis (OA), and intervertebral disc degenerative disease (DDD) constitute major public health problems that are anticipated to grow significantly as the human population ages. However, many aspects concerning the molecular mechanisms underlying their onset and progression remain unclear. DESIGN: This narrative review critically analyzes the molecular mechanisms underlying the inflammation-associated pathogenesis of the aforementioned joint diseases...
October 24, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29072150/evaluating-the-relationship-between-hospital-antibiotic-use-and-antibiotic-resistance-in-common-nosocomial-pathogens
#19
Annie Wang, Nick Daneman, Charlie Tan, John S Brownstein, Derek R MacFadden
OBJECTIVE The relationship between hospital antibiotic use and antibiotic resistance is poorly understood. We evaluated the association between antibiotic utilization and resistance in academic and community hospitals in Ontario, Canada. METHODS We conducted a multicenter observational ecological study of 37 hospitals in 2014. Hospital antibiotic purchasing data were used as an indicator of antibiotic use, whereas antibiotic resistance data were extracted from hospital indexes of resistance. Multivariate regression was performed, with antibiotic susceptibility as the primary outcome, antibiotic consumption as the main predictor, and additional covariates of interest (ie, hospital type, laboratory standards, and patient days)...
October 26, 2017: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/29065873/high-variability-of-tb-hiv-hepatitis-c-treatment-and-opioid-substitution-therapy-among-prisoners-in-germany
#20
Jana Müller, Daniel Schmidt, Christian Kollan, Marc Lehmann, Viviane Bremer, Ruth Zimmermann
BACKGROUND: In Germany, medical care of prisoners is completely separated from extramural health care. The extent and quality of medical care among prisoners in Germany are therefore largely unknown. We performed a secondary data analysis of pharmacy sales data for tuberculosis (TB), HIV, hepatitis C (HCV) and opioid substitution treatment (OST) delivered to prisons in 11 federal states (FS) in Germany between 01/2012 and 03/2013. The aims of this study were to assess (i) the treatment availability for the selected diseases and OST in German prisons, (ii) the proportion of prisoners treated per FS and overall for TB, HIV, HCV and OST during the study period...
October 25, 2017: BMC Public Health
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