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https://www.readbyqxmd.com/read/28207657/3-tesla-kinematic-mri-of-the-cervical-spine-for-evaluation-of-adjacent-level-disease-after-monosegmental-anterior-cervical-discectomy-and-arthroplasty-results-of-2-year-follow-up
#1
Steffen K Fleck, Soenke Langner, Christian Rosenstengel, Rebecca Kessler, Marc Matthes, Jan-Uwe Müller, Inga Langner, Sascha Marx, Henry W S Schroeder
STUDY DESIGN: We prospectively evaluated adjacent disc levels after anterior cervical discectomy and arthroplasty (ACDA) using kinematic magnetic resonance imaging (MRI) and plain functional radiographs. OBJECTIVE: ACDA is an established treatment for degenerative cervical disc disease. The objective of this study was to evaluate the use of kinematic MRI for assessing the range of motion (ROM) before and after ACDA compared with plain functional radiographs and to evaluate adjacent degenerative disc disease (aDDD) at mid-term follow-up...
February 15, 2017: Spine
https://www.readbyqxmd.com/read/28186216/absolute-configuration-determination-through-the-unique-intramolecular-excitonic-coupling-in-the-circular-dichroisms-of-o-p-ddt-and-o-p-ddd-a-combined-experimental-and-theoretical-study
#2
Hiroki Tanaka, Yoshihisa Inoue, Takeshi Nakano, Tadashi Mori
Circular dichroisms (CDs) of the o,p'-isomers of 1,1,1-trichloro- and 1,1-dichloro-2,2-bis(chlorophenyl)ethanes (DDT and DDD) were investigated experimentally and theoretically. A series of strong Cotton effect peaks in a characteristic negative-negative-positive-negative, or its mirror-imaged, pattern were observed in the CD spectra of these persistent organic pollutants. The theoretical CD spectra at the SAC-CI/B95(d) and RI-CC2/def2-TZVPP levels well reproduced the experimental ones, enabling us to unambiguously assign the absolute configuration of (+)-DDT and (-)-DDD as S...
February 10, 2017: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/28166369/heterozygous-truncation-mutations-of-the-smc1a-gene-cause-a-severe-early-onset-epilepsy-with-cluster-seizures-in-females-detailed-phenotyping-of-10-new-cases
#3
Joseph D Symonds, Shelagh Joss, Kay A Metcalfe, Suresh Somarathi, Jamie Cruden, Anita M Devlin, Alan Donaldson, Nataliya DiDonato, David Fitzpatrick, Frank J Kaiser, Anne K Lampe, Melissa M Lees, Ailsa McLellan, Tara Montgomery, Vivek Mundada, Lesley Nairn, Ajoy Sarkar, Jens Schallner, Jelena Pozojevic, Ilaria Parenti, Jeen Tan, Peter Turnpenny, William P Whitehouse, Sameer M Zuberi
OBJECTIVE: The phenotype of seizure clustering with febrile illnesses in infancy/early childhood is well recognized. To date the only genetic epilepsy consistently associated with this phenotype is PCDH19, an X-linked disorder restricted to females, and males with mosaicism. The SMC1A gene, which encodes a structural component of the cohesin complex is also located on the X chromosome. Missense variants and small in-frame deletions of SMC1A cause approximately 5% of Cornelia de Lange Syndrome (CdLS)...
February 6, 2017: Epilepsia
https://www.readbyqxmd.com/read/28162371/-148-population-exposed-to-the-prescription-of-opioid-drugs-groups-n02a-and-r05da-of-the-atc-ddd-classification-in-the-sanitary-region-of-lleida-catalonia-spain-between-2010-and-2012
#4
J Canal-Sotelo, R Gonzalez-Rubio, J Lopez-Ribes, E Barallat-Gimeno, N Arraras-Torrelles, A Martin-Marco
No abstract text is available yet for this article.
April 2016: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28161282/use-of-anti-allergic-drugs-in-children
#5
C Suárez-Castañón, G Modroño-Riaño, G Solís-Sánchez
Allergic rhinitis is one of the most frequent chronic diseases in children. We have analysed the prescriptions habits of anti-allergic medications in children (<14 years old) in 2011. We calculated the DHD (N°DDD/1000 children/day) for oral antihistamines and intranasal therapies (corticoids and antihistamines) in the region (sanitary districts I-VIII) and specifically in sanitary district V (health centres 1-15). We also reviewed the clinical records in six health centres in sanitary district V to know more details about age and diagnosis and to value if these prescriptions are adequate...
February 1, 2017: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/28156008/a-device-histogram-based-simple-predictor-of-mortality-risk-in-icd-and-crt-d-patients-the-heart-rate-score
#6
Bruce L Wilkoff, Mark Richards, Arjun Sharma, Nicholas Wold, Paul Jones, David Perschbacher, Brian Olshansky
BACKGROUND: We hypothesized survival in cardioverter defibrillator (ICD) and cardiac resynchronization defibrillator (CRT-D) patients is predicted by baseline Heart rate Score. METHODS: Heart rate Score is determined from the atrial paced and sensed histogram of a DDD ICD or CRT-D, and defined as percent of beats in the histogram in the tallest 10 beat/minute range bin. It was calculated at initial remote monitoring for patients enrolled in LATITUDE® without persistent atrial fibrillation (AF), and with pulse generators implanted 2006-2011...
February 3, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/28153416/evaluating-the-effectiveness-of-pollution-control-measures-via-the-occurrence-of-ddts-and-hchs-in-wet-deposition-of-an-urban-center-china
#7
Ling-Chuan Guo, Lian-Jun Bao, Shao-Meng Li, Shu Tao, Eddy Y Zeng
Wet deposition is not only a mechanism for removing atmospheric pollutants, but also a process which reflects loadings of atmospheric pollutants. Our previous study on wet deposition examined the effectiveness of short-term control measures on atmospheric particulate pollution, which were partly effective for organic pollutants of current input sources. In the present study, dichlorodiphenyltrichloroethanes (DDTs) and hexachlorocyclohexanes (HCHs), representative of legacy contaminants, were measured in the same samples collected throughout the entire year of 2010 in Guangzhou, a large urban center in South China...
January 30, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28151491/clinical-and-molecular-consequences-of-disease-associated-de-novo-mutations-in-satb2
#8
Hemant Bengani, Mark Handley, Mohsan Alvi, Rita Ibitoye, Melissa Lees, Sally Ann Lynch, Wayne Lam, Madeleine Fannemel, Ann Nordgren, H Malmgren, M Kvarnung, Sarju Mehta, Shane McKee, Margo Whiteford, Fiona Stewart, Fiona Connell, Jill Clayton-Smith, Sahar Mansour, Shehla Mohammed, Alan Fryer, Jenny Morton, Detelina Grozeva, Tara Asam, David Moore, Alejandro Sifrim, Jeremy McRae, Matthew E Hurles, Helen V Firth, F Lucy Raymond, Usha Kini, Christoffer Nellåker, Ddd Study, David R FitzPatrick
PURPOSE: To characterize features associated with de novo mutations affecting SATB2 function in individuals ascertained on the basis of intellectual disability. METHODS: Twenty previously unreported individuals with 19 different SATB2 mutations (11 loss-of-function and 8 missense variants) were studied. Fibroblasts were used to measure mutant protein production. Subcellular localization and mobility of wild-type and mutant SATB2 were assessed using fluorescently tagged protein...
February 2, 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/28150955/randomized-clinical-trial-of-matching-client-alcohol-use-disorder-severity-and-level-of-cognitive-functioning-to-treatment-setting-a-partial-replication-and-extension
#9
Robert G Rychtarik, Neil B McGillicuddy, George D Papandonatos, Robert B Whitney, Gerard J Connors
In a tightly controlled, clinical research environment, Rychtarik et al. (2000) found that individuals with an alcohol use disorder (AUD) benefited more from inpatient (IP) than outpatient care, if they presented with high alcohol problem severity and/or low cognitive functioning. This study sought to (a) validate and extend these findings within the uncontrolled environment of a community-based treatment center and (b) test whether inpatients had fewer days of involuntary abstinence (e.g., incarcerations), controlling for differences in treatment expectancy across care settings...
February 2, 2017: Psychology of Addictive Behaviors: Journal of the Society of Psychologists in Addictive Behaviors
https://www.readbyqxmd.com/read/28138924/dissociation-and-alterations-in-brain-function-and-structure-implications-for-borderline-personality-disorder
#10
REVIEW
Annegret Krause-Utz, Rachel Frost, Dorina Winter, Bernet M Elzinga
Dissociation involves disruptions of usually integrated functions of consciousness, perception, memory, identity, and affect (e.g., depersonalization, derealization, numbing, amnesia, and analgesia). While the precise neurobiological underpinnings of dissociation remain elusive, neuroimaging studies in disorders, characterized by high dissociation (e.g., depersonalization/derealization disorder (DDD), dissociative identity disorder (DID), dissociative subtype of posttraumatic stress disorder (D-PTSD)), have provided valuable insight into brain alterations possibly underlying dissociation...
January 2017: Current Psychiatry Reports
https://www.readbyqxmd.com/read/28126703/ecological-assessment-of-clinicians-antipsychotic-prescription-habits-in-psychiatric-inpatients-a-novel-web-and-mobile-phone-based-prototype-for-a-dynamic-clinical-decision-support-system
#11
Sofian Berrouiguet, Maria Luisa Barrigón, Sara A Brandt, George C Nitzburg, Santiago Ovejero, Raquel Alvarez-Garcia, Juan Carballo, Michel Walter, Romain Billot, Philippe Lenca, David Delgado-Gomez, Juliette Ropars, Ivan de la Calle Gonzalez, Philippe Courtet, Enrique Baca-García
BACKGROUND: Electronic prescribing devices with clinical decision support systems (CDSSs) hold the potential to significantly improve pharmacological treatment management. OBJECTIVE: The aim of our study was to develop a novel Web- and mobile phone-based application to provide a dynamic CDSS by monitoring and analyzing practitioners' antipsychotic prescription habits and simultaneously linking these data to inpatients' symptom changes. METHODS: We recruited 353 psychiatric inpatients whose symptom levels and prescribed medications were inputted into the MEmind application...
January 26, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28126469/antidiabetic-medications-use-trends-in-an-andalusian-region-from-2001-to-2014
#12
Rocío López-Sepúlveda, María Ángeles García Lirola, Esther Espínola García, Jose María Jurado Martínez, Salvadora Martín Sances, Sonia Anaya Ordóñez, José Cabeza Barrera
PURPOSE: There is a widening range of antidiabetic medications available; however changes in consumption patterns remain poorly documented. The aim of this study is to analyze the evolution of consumption of antidiabetic medications during the period 2001-2014 in an Andalusian region. METHODS: All antidiabetic medicines on the market were selected for analysis. Consumption data were obtained for the 15-year period and were expressed in defined daily doses (DDD) per 1000 inhabitants per day (DHD)...
January 23, 2017: Primary Care Diabetes
https://www.readbyqxmd.com/read/28124550/the-unfeasible-made-feasible-lumbar-minimally-invasive-hybrid-stabilization-with-dynamic-rod-and-mini-open-tlif
#13
Giuseppe M Barbagallo, Francesco Certo
BACKGROUND: Posterior dynamic stabilization of the lumbar spine is spreading as a viable alternative to spinal fusion, aiming to achieve an equally satisfactory clinical outcome without making the spine completely rigid. We describe the feasibility of a minimally invasive surgical technique used to implant a hybrid system and perform a mini-open (m-open) transforaminal lumbar interbody fusion (TLIF) in patients suffering from degenerative spondylolistesis and adjacent level's degenerative disc disease (DDD)...
January 26, 2017: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/28121271/pesticide-contaminants-in-selected-species-of-edible-wild-mushrooms-from-the-north-eastern-part-of-poland
#14
Michalina Gałgowska, Renata Pietrzak-Fiećko
The aim of this study was to determine the level of chlorinated hydrocarbon residues in selected edible mushrooms from north-eastern Poland. The experiment was carried out on 45 samples consisting of 15 fruiting bodies each of the following species: Boletus edulis, Imleria badia and Cantharellus cibarius. Dried samples were subjected to extraction of lipids with a Soxhlet and a standard procedure-based on the decomposition of lipids by concentrated sulfuric acid and the release of organic insecticides to the hexane layer-was used to determine chlorinated hydrocarbons...
March 4, 2017: Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes
https://www.readbyqxmd.com/read/28114923/intervertebral-disc-and-vertebral-endplate-subchondral-changes-associated-with-modic-1-changes-of-the-lumbar-spine-a-cross-sectional-study
#15
Christelle Nguyen, Marylène Jousse, Serge Poiraudeau, Antoine Feydy, François Rannou
BACKGROUND: Modic 1 changes are usually associated with degenerative disc disease (DDD). We aimed to compare Modic 1 changes with advanced degenerative disc disease (>50%-intervertebral space narrowing [IVSN]) to Modic 1 changes with less advanced lumbar degenerative disc disease (≤50%-IVSN). METHODS: We conducted a cross-sectional study. The computerized MRI database from a French tertiary care hospital was searched. Patients were included if they were ≥ 18 years old and had a lumbar MRI between January 1, 2006 and January 31, 2008, that showed a Modic 1 signal at a single level...
January 23, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28113064/organochlorine-pesticides-in-residential-soils-and-sediments-within-two-main-agricultural-areas-of-northwest-mexico-concentrations-enantiomer-compositions-and-potential-sources
#16
José Luis Sánchez-Osorio, José Vinicio Macías-Zamora, Nancy Ramírez-Álvarez, Terry F Bidleman
The agricultural Mexicali and Yaqui valleys (MV, YV) in northwest Mexico were heavily treated with organochlorine pesticides in the past. Residential soils and agricultural drain sediments were sampled in 2008-2009 and analyzed for DDTs (o,p'- and p,p'- isomers of DDE, DDD and DDT); hexachlorocyclohexanes (α-, β-, γ- and δ-HCH) and chlordanes (trans-chlordane, cis-chlordane, heptachlor and heptachlor exo-epoxide). Geometric means (GMs) (ng g(-1) dry weight) were: MV soils (n = 27) ΣDDT 22, ΣHCH 0.80, ΣCHL 0...
January 5, 2017: Chemosphere
https://www.readbyqxmd.com/read/28110018/historical-records-and-sources-of-polycyclic-aromatic-hydrocarbons-pahs-and-organochlorine-pesticides-ocps-in-sediment-from-a-representative-plateau-lake-china
#17
Hezhong Yuan, Enfeng Liu, Enlou Zhang, Wenlei Luo, Liang Chen, Cheng Wang, Qi Lin
The PAH and OCP concentrations in sediment cores collected from a deep lake were measured and evaluated chronologically. The results indicated that the PAH and OCP concentrations significantly increased from the 1950s to the 1990s and subsequently decreased to recent years. Integrated molecular diagnostic ratios indicated that the predominant petrogenic sources occurred from the 1950s-1980s. Petroleum and fuel combustion dominated the source of contamination more recently as a result of energy structure changes in this region...
January 9, 2017: Chemosphere
https://www.readbyqxmd.com/read/28104713/multimerization-properties-of-piggymac-a-domesticated-piggybac-transposase-involved-in-programmed-genome-rearrangements
#18
Emeline Dubois, Nathalie Mathy, Vinciane Régnier, Julien Bischerour, Céline Baudry, Raphaëlle Trouslard, Mireille Bétermier
During sexual processes, the ciliate Paramecium eliminates 25-30% of germline DNA from its somatic genome. DNA elimination includes excision of ∼45 000 short, single-copy internal eliminated sequences (IESs) and depends upon PiggyMac (Pgm), a domesticated piggyBac transposase that is essential for DNA cleavage at IES ends. Pgm carries a core transposase region with a putative catalytic domain containing three conserved aspartic acids, and a downstream cysteine-rich (CR) domain. A C-terminal extension of unknown function is predicted to adopt a coiled-coil (CC) structure...
January 18, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28101968/defined-daily-doses-ddd-do-not-accurately-reflect-opioid-doses-used-in-contemporary-chronic-pain-treatment
#19
Suzanne Nielsen, Natasa Gisev, Raimondo Bruno, Wayne Hall, Milton Cohen, Briony Larance, Gabrielle Campbell, Marian Shanahan, Fiona Blyth, Nicholas Lintzeris, Sallie Pearson, Richard Mattick, Louisa Degenhardt
OBJECTIVE: To assess how well the defined daily dose (DDD) metric reflects opioid utilisation among chronic non-cancer pain patients. DESIGN: Descriptive, cross-sectional study, utilising a 7-day medication diary. SETTING: Community-based treatment settings, Australia. SUBJECTS: A sample of 1101 people prescribed opioids for chronic non-cancer pain. METHODS: Opioid dose data was collected via a self-completed 7-day medication diary capturing names, strengths and doses of each medication taken in the past week...
January 19, 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/28100473/delineating-the-phenotypic-spectrum-of-bainbridge-ropers-syndrome-12-new-patients-with-de-novo-heterozygous-loss-of-function-mutations-in-asxl3-and-review-of-published-literature
#20
M Balasubramanian, J Willoughby, A E Fry, A Weber, H V Firth, C Deshpande, J N Berg, K Chandler, K A Metcalfe, W Lam, D Pilz, S Tomkins
BACKGROUND: Bainbridge-Ropers syndrome (BRPS) is a recently described developmental disorder caused by de novo truncating mutations in the additional sex combs like 3 (ASXL3) gene. To date, there have been fewer than 10 reported patients. OBJECTIVES: Here, we delineate the BRPS phenotype further by describing a series of 12 previously unreported patients identified by the Deciphering Developmental Disorders study. METHODS: Trio-based exome sequencing was performed on all 12 patients included in this study, which found a de novo truncating mutation in ASXL3...
January 18, 2017: Journal of Medical Genetics
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