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https://www.readbyqxmd.com/read/28812385/increased-acetaminophen-related-calls-to-finnish-pic-better-reflect-acetaminophen-sales-than-serious-poisonings
#1
Mikko J Parry, Helena Isoniemi, Anna-Maria Koivusalo, Kalle Hoppu
OBJECTIVE: Acetaminophen (APAP) or paracetamol is a commonly encountered medicine in poisonings. We studied the changes in APAP related calls to the Finnish poison information centre (FPIC), and serious intoxications, involving hepatotoxicity or death in 2001-2014. These data were compared with paracetamol sales in Finland. METHODS: This is a retrospective analysis of the FPIC database calls, national cause of death registry, registries of liver transplantations and molecular adsorbent recycling system (MARS)-treated patients from Helsinki University Hospital together with the National Institute of Health and Welfare registry of patients hospitalized...
August 16, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28811990/clinical-outcomes-of-total-disc-replacement-versus-anterior-lumbar-interbody-fusion-for-surgical-treatment-of-lumbar-degenerative-disc-disease
#2
Tobias A Mattei, Jennifer Beer, Alisson R Teles, Azeem A Rehman, Jean Aldag, Dzung Dinh
STUDY DESIGN: The authors performed a retrospective controlled study of patients diagnosed with lumbar degenerative disc disease who received surgical intervention (either total disc replacement [TDR]/Activ-L or anterior lumbar interbody fusion [ALIF]) at a single tertiary-care hospital from 2007-2010. OBJECTIVES: To investigate the clinical outcomes after TDR in comparison with ALIF for surgical treatment of lumbar degenerative disc disease (DDD). METHODS: Analyzed data included intra-operative blood loss, time to return to work, and clinical outcomes as evaluated through the Oswestry Disability Index (ODI) and the Visual Analog Scale (VAS) pain questionnaires pre-operatively and at 6 weeks, 3 months, 6 months, and 1 year postoperative follow-up...
August 2017: Global Spine Journal
https://www.readbyqxmd.com/read/28809444/circannual-variation-of-mitotane-and-its-metabolites-plasma-levels-in-patients-with-adrenocortical-carcinoma
#3
Jessica Cusato, Silvia De Francia, Sarah Allegra, Simona Carrella, Elisa Pirro, Francesca Maria Piccione, Francesca De Martino, Anna Ferrero, Fulvia Claudia Daffara, Massimo Terzolo, Alfredo Berruti, Francesco Di Carlo, Marco Tampellini, Antonio D'Avolio
OBJECTIVES: Mitotane is the reference drug for the adrenocortical carcinoma treatment; its pharmacological activity seems to depend on drug transformation in two active metabolites: o,p'-DDE (dichlorodiphenylethene) and o,p'-DDA (dichlorodiphenylacetate). Mitotane and metabolites are lipophilic agents; thus, they tend to accumulate into adipose tissues (white and brown), which change their prevalence seasonally. Aim of the work was to evaluate mitotane and metabolites plasma levels variation over the year, in adrenocortical cancer patients treated with Lysodren(®) for at least 6 months...
August 15, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28800399/price-and-utilisation-differences-for-statins-between-four-countries
#4
L P Thai, A I Vitry, J R Moss
INTRODUCTION: Australia, England, France and New Zealand use different policies to regulate their medicines market, which can impact on utilisation and price. OBJECTIVES: To compare the prices and utilisation of statins in Australia, England, France and New Zealand from 2011 to 2013. METHODS: Utilisation of statins in the four countries was compared using Defined Daily Doses (DDD) per 1000 inhabitants per year. Pairwise Laspeyres and Paasche index comparisons were conducted comparing the price and utilisation of statins...
August 11, 2017: Expert Review of Pharmacoeconomics & Outcomes Research
https://www.readbyqxmd.com/read/28798244/atypical-haemolytic-uremic-syndrome-ahus-and-membranoproliferative-glomerulonephritis-mpgn-different-diseases-or-a-spectrum-of-complement-mediated-glomerular-diseases
#5
Ghada A Ankawi, William F Clark
Historically, patients with kidney diseases caused by genetic or acquired dysregulation of the complement alternative pathway have been grouped into clinical syndromes, C3 glomerulopathy (C3GN/DDD) and thrombotic microangiopathy (TMA), specifically atypical haemolytic uremic syndrome (aHUS). Recent data suggested that these diseases share a common pathophysiology and that patients can transition between glomerulopathies in this spectrum. Histopathologically, the main difference cited is the immunofluorescence (IF) findings, with C3 predominance in C3 glomerulopathy (compared with immunoglobulins and complements in immune complex-mediated membranoproliferative glomerulonephritis (MPGN)) and negative IF in TMA...
August 10, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28797142/temporal-trends-of-mercury-and-organohalogen-contaminants-in-great-blue-heron-eggs-from-the-st-lawrence-river-qu%C3%A3-bec-canada-1991-2011-and-relationships-with-tracers-of-feeding-ecology
#6
Louise Champoux, Monique Boily
Since 1991, great blue heron (Ardea herodias) eggs have been collected and analyzed for mercury (Hg), persistent organic contaminants (OCs), brominated and non-brominated flame retardants (FRs) as well as stable isotopes δ(13)C and δ(15)N. In the present study, temporal trends of contaminants were analyzed in eggs sampled in four regions along the St. Lawrence River (Quebec, Canada) and inland sites using new and previously published data. Most contaminants declined significantly over time in most regions...
August 6, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28794249/not-all-scn1a-epileptic-encephalopathies-are-dravet-syndrome-early-profound-thr226met-phenotype
#7
Lynette G Sadleir, Emily I Mountier, Deepak Gill, Suzanne Davis, Charuta Joshi, Catherine DeVile, Manju A Kurian, Simone Mandelstam, Elaine Wirrell, Katherine C Nickels, Hema R Murali, Gemma Carvill, Candace T Myers, Heather C Mefford, Ingrid E Scheffer
OBJECTIVE: To define a distinct SCN1A developmental and epileptic encephalopathy with early onset, profound impairment, and movement disorder. METHODS: A case series of 9 children were identified with a profound developmental and epileptic encephalopathy and SCN1A mutation. RESULTS: We identified 9 children 3 to 12 years of age; 7 were male. Seizure onset was at 6 to 12 weeks with hemiclonic seizures, bilateral tonic-clonic seizures, or spasms...
August 9, 2017: Neurology
https://www.readbyqxmd.com/read/28791578/protective-role-of-antioxidants-capacity-of-hyrtios-aff-erectus-sponge-extract-against-mixture-of-persistent-organic-pollutants-pops-induced-hepatic-toxicity-in-mice-liver-biomarkers-and-ultrastructural-study
#8
Nehad M Abd El-Moneam, Mohamed A Shreadah, Samy A El-Assar, Asmaa Nabil-Adam
The current study investigates the hepatoprotective effect of Hyrtios aff. Erectus sponge extract against POPs intoxication on endogenous antioxidant enzymes and lipid peroxidation in mice liver tissue. In the present study, the mice BALB/C were assigned into four groups: group I: received saline subcutaneously for 7 days and served as negative control; group II: received subcutaneously for 7 days, 130.6 mg/100 g/b. w/day POPs mixture(mixture of PCB 28, PCB 52,, PCB 101, PCB 118, PCB 153, PCB 138 and PCB 180, alpha-Hexachlorocyclohexane, beta-Hexachloro-cyclohexane, gamma-hexachlorocyclohexane, Aldrin, O,P'-DDE, Dieldrin, P,p DDE, O,P DDD, Endrin, P,p DDD and P,pDDT were extracted from sediments collected from Lake Mariout), and served as induced group; group III: pretreated with Hyrtios aff...
August 8, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28791354/collagen-type-ii-is-downregulated-in-the-degenerative-nucleus-pulposus-and-contributes-to-the-degeneration-and-apoptosis-of-human-nucleus-pulposus-cells
#9
Chengjie Lian, Bo Gao, Zizhao Wu, Xianjian Qiu, Yan Peng, Anjing Liang, Caixia Xu, Peiqiang Su, Dongsheng Huang
Degenerative disc disease (DDD) is a common degenerative condition initiated mainly within the nucleus pulposus (NP). To date, the etiopathogenesis of DDD remains unclear, and because no effective therapeutic strategies are available to target its pathological processes, DDD is still treated with symptomatic interventions that are far from adequate. Collagen type II is one of the major matrix components of the NP, and is considered to be essential to NP homeostasis. However, the specific mechanisms by which collagen type II influences NP cells remain unknown...
August 4, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28780637/selected-organochlorines-in-human-blood-and-urine-in-the-south-of-the-russian-far-east
#10
Vasiliy Yu Tsygankov, Nadezhda K Khristoforova, Olga N Lukyanova, Margarita D Boyarova, Pavel F Kiku, Marina V Yarygina
The trace OCP concentrations, such as α-, β-, and γ-HCH, DDT and its metabolites (DDD and DDE) in blood and urine of residents from the south of the Russian Far East was revealed. A large range of OCPs was found in the urine: α- and γ-isomers of HCH, DDT and DDE. The only β-HCH was detected in the blood; this indicates its persistence and the difficulty of excretion this substance from the organism. The total trace OCP concentration, found in the biological fluids of residents of the south of the Russian Far East, providing further evidence that these organic contaminants persist in the environment...
August 5, 2017: Bulletin of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28774865/shifts-in-antimicrobial-consumption-and-infection-rates-before-and-during-a-piperacillin-tazobactam-shortage
#11
S Travis King, Katie E Barber, Jason J Parham, Kayla R Stover
BACKGROUND: Anti-infective shortages represent a growing threat to the optimal management of the infected patient and alter the institutional selective pressure against hospital-acquired infections. The objective of this analysis was to assess the impact that a shortage of piperacillin-tazobactam had on the overall antibacterial use and HAI rates at an academic institution. METHODS: Antimicrobial use and infection data were extracted from TheraDoc Clinical Surveillance Software (Premier, Inc...
July 31, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28774216/3d-printed-drug-delivery-devices-perspectives-and-technical-challenges
#12
Mirja Palo, Jenny Holländer, Jaakko Suominen, Jouko Yliruusi, Niklas Sandler
The technological advancements in the pharmaceutical field are constantly improving and provide various possibilities for meeting the needs of personalized drug therapy. The three-dimensional (3D) printing technology has endless potential in the fabrication of patient-specific drug delivery devices (DDD) and dosage forms as the technological development is progressing. Moreover, the rapidly evolving research on 3D printed DDD has enabled us to determine several challenges related to the manufacturing and marketing of personalized drug delivery systems...
August 4, 2017: Expert Review of Medical Devices
https://www.readbyqxmd.com/read/28764122/depth-distribution-possible-sources-and-toxic-risk-assessment-of-organochlorine-pesticides-ocps-in-different-river-sediment-cores-affected-by-urbanization-and-reclamation-in-a-chinese-delta
#13
Wei Wang, Junhong Bai, Guangliang Zhang, Xin Wang, Jia Jia, Baoshan Cui, Xinhui Liu
Sediment cores were collected in urban (0-50 cm), rural (0-40 cm) and reclamation-affected river (0-40 cm) environments in the Pearl River Delta. Concentrations of 16 organochlorine pesticides (OCPs) were determined in all collected samples to identify the depth-distribution, possible sources and ecotoxicological risks of OCPs in river sediments affected by urbanization and reclamation in a Chinese delta. The results showed that the top 10 cm of rural river sediments had slightly lower concentrations of the 16 OCPs compared to urban and reclamation-affected rivers, whereas the 30-40 cm sediment layers in the rural river showed higher levels of the 16 OCPs...
July 27, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28758337/changes-in-the-distribution-of-colonising-and-infecting-candida-spp-isolates-antifungal-drug-consumption-and-susceptibility-in-a-french-intensive-care-unit-a-10-year-study
#14
Milène Sasso, Claire Roger, Magali Sasso, Hélène Poujol, Saber Barbar, Jean-Yves Lefrant, Laurence Lachaud
Monitoring fungal ecology and resistance to antifungal agents within intensive care units (ICU) is essential for the management of invasive fungal infections. Therefore, a retrospective descriptive study was carried in the ICU of Nimes University Hospital, France, from 2007 to 2016. As the majority of invasive fungal infections in ICU are caused by Candida species, the study objectives were to describe Candida species distribution, to assess candidaemia incidence and to monitor the antifungal drug susceptibility of Candida isolates and the consumption of antifungal agents...
July 31, 2017: Mycoses
https://www.readbyqxmd.com/read/28738509/ambient-sediment-quality-conditions-in-minnesota-lakes-usa-effects-of-watershed-parameters-and-aquatic-health-implications
#15
Judy L Crane
Surficial sediments were collected from 50 randomly selected Minnesota lakes, plus four a priori reference lakes, in 2007. The lakes encompassed broad geographic coverage of the state and included a variety of major land uses in the surrounding watersheds. Sediment samples were analyzed for a suite of metals, metalloids, persistent organic pollutants, total organic carbon, and particle size fractions. In addition, a small fish survey was conducted to assess PBDEs in both whole fish and fish tissues. Sediment quality in this set of lakes ranged from good (43%) to moderate (57%) based on an integrative measure of multiple contaminants...
July 18, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28737099/concentrations-and-human-health-risk-assessment-of-ddt-and-its-metabolites-in-free-range-and-commercial-chicken-products-from-kwazulu-natal-south-africa
#16
L A Thompson, Y Ikenaka, Y B Yohannes, J J van Vuren, V Wepener, N J Smit, W S Darwish, S M M Nakayama, H Mizukawa, M Ishizuka
Organochlorine pesticides such as dichlorodiphenyltrichloroethane (DDT) have been used in agriculture and for disease control purposes over many decades. Reports suggest that DDT exposure may result in a number of adverse effects in humans. In the KwaZulu-Natal Province of South Africa, DDT is sprayed annually in homes (indoor residual spraying) to control the mosquito vector of malaria. In the northern part of the Province, samples of free-range chicken meat (n = 48) and eggs (n = 13), and commercially-produced chicken meat (n = 6) and eggs (n = 11) were collected and analysed...
July 24, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/28735057/brazil-s-resolutions-to-regulate-the-sale-of-antibiotics-impact-on-consumption-and-escherichia-coli-resistance-rates
#17
Karen P H Mattos, Marília B Visacri, Júlia C F Quintanilha, Gustavo R Lloret, Maria A Cursino, Anna S Levin, Carlos E Levy, Patricia Moriel
OBJECTIVE: The aim of this study was to determine the impact of two resolutions to restrict antibiotic use (RDCs no. 44/2010 and 20/2011) in the Campinas metropolitan area (Sao Paulo, Brazil) on antibiotic consumption, resistance rates, and trends in Escherichia coli-causing community-acquired urinary tract infection (UTI). METHODS: The annual retail sale information of antibiotics from drugstores in the Campinas metropolitan area between 2008 and 2012 were obtained through the Intercontinental Medical Statistics Health of Brazil...
July 19, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28730750/improving-type-2-diabetes-mellitus-glycaemic-outcomes-is-possible-without-spending-more-on-medication-lessons-from-the-uk-national-diabetes-audit
#18
Adrian H Heald, Mark Livingston, Nagaraj Malipatil, Michal Becher, Joyce Craig, Mike Stedman, Anthony A Fryer
OBJECTIVES: There is continuing discussion globally about how to optimise outcomes for type 2 diabetes (T2DM) patients. In the UK, national (NICE) guidance was updated in 2016 (NG28). We aimed to determine the factors at a GP practice level that relate to glycaemic control outcome. METHODS: Data was accessed from 4,050 GP practices (GPP) (50% of total) covering 1.6 million T2DM patients in the UK National Diabetes Audit 2013-14 and 2014-15. This reported T2DM population characteristics, services and outcomes, including % total glycaemic control (TGC) (at 67...
July 20, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28728260/-clinical-analysis-of-pacing-therapy-and-treatment-of-complications-during-follow-up-in-children
#19
P J Zhao, Y W Chen, F Li, Y Li, J P Yang, J J Wu
Objective: To analyze characteristics of permanent pacemaker implantation in children as well as treatment and prognosis of complications. Method: Clinical data of children who underwent endocardial or epicardial permanent pacemaker implantation between April 2000 and June 2016 in Shanghai Xinhua Hospital and Shanghai Children's Medical Center were analyzed retrospectively. These patients were discharged 5 days after implantation. Electrocardiogram, chest X ray, echocardiography and pacemaker programming were performed during follow-up...
July 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/28728131/the-distribution-of-organochlorine-pesticides-in-sediments-from-isimangaliso-wetland-park-ecological-risks-and-implications-for-conservation-in-a-biodiversity-hotspot
#20
Archibold Buah-Kwofie, Marc S Humphries
The iSimangaliso Wetland Park World Heritage site, located on the east coast of South Africa, spans ∼3300 km(2) and constitutes the largest protected estuarine environment for hippopotami, crocodiles and aquatic birds in Africa. Given the ecological importance of this site and continued use of organochlorine pesticides (OCPs) in the region, this study focused on the nature, distribution and potential sources of organochlorine contamination within iSimangaliso Wetland Park. OCPs were widely distributed in surface sediment samples obtained from the four main Ramsar wetland systems within the park (Lake St Lucia, Mkhuze, Lake Sibaya and Kosi Bay)...
July 17, 2017: Environmental Pollution
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