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https://www.readbyqxmd.com/read/28625400/successful-treatment-of-ventricular-fibrillation-storm-triggered-by-short-long-short-sequence-time-to-avoid-managed-ventricular-pacing
#1
Hilmi Alnsasra, Yuval Konstantino, Sergiy Bereza, Moti Haim
Sudden cardiac death (SCD) in hypertrophic cardiomyopathy (HCM) is caused by ventricular tachyarrhythmia that can be effectively treated by implantable cardioverter defibrillator (ICD) therapy. We report of a 28-year-old man with HCM and a dual chamber ICD, originally implanted for primary prevention of SCD, (programmed to AAI(R)-DDD(R); managed ventricular pacing (MVP) mode, Medtronic Inc. St Paul, MN USA). He presented with recurrent ICD shocks due to ventricular fibrillation (VF) despite antiarrhythmic therapy...
June 8, 2017: Journal of Electrocardiology
https://www.readbyqxmd.com/read/28623386/the-antipsychotic-agent-quetiapine-is-increasingly-not-used-as-such-dispensed-prescriptions-in-norway-2004-2015
#2
Pål Gjerden, Jørgen G Bramness, Ingunn Fride Tvete, Lars Slørdal
PURPOSE: The antipsychotic agent quetiapine was introduced in Norway in 2003. We have assessed changes in dispensed prescriptions, including dosing, of quetiapine in Norway from 2004 to 2015. METHODS: Data on the sales of antipsychotics and antidepressants were drawn from the Norwegian Prescription Database. A total of 47,474 outpatients filled 195,622 prescriptions of quetiapine. Reimbursement codes, use of antipsychotics or antidepressants 12 months prior to the first prescription of quetiapine and estimated mean volume used measured as defined daily doses (DDDs) per day were used as proxies for diagnoses...
June 16, 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28617681/psychotropic-drugs-prescription-in-undocumented-migrants-and-indigent-natives-in-italy
#3
Cesare Cerri, Gianfrancesco Fiorini, Silvia Bini, Antonello E Rigamonti, Nicoletta Marazzi, Alessandro Sartorio, Silvano G Cella
To evaluate psychotropic drug use in undocumented migrants and natives in the same conditions of poverty. We studied drug dispensation by a nongovernmental organization during the year 2014. Drugs were identified according to the Anatomical Chemical Therapeutic classification and their quantity was measured in defined daily doses (DDD). We determined the percentage of patients taking at least one medicine with psychotropic activity in relation to the total number of patients receiving medicines of any class...
June 14, 2017: International Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28608330/opioid-analgesic-use-in-australia-and-the-netherlands-a-cross-country-comparison
#4
Francisca N Wagemaakers, Samantha A Hollingworth, Sanne Kreijkamp-Kaspers, Ernest H L Tee, Anne J Leendertse, Mieke L van Driel
Background Increasing use of opioid analgesics (OA) has been reported worldwide. Objective To compare the use of OA in two countries in order to better understand these trends. Setting Outpatient settings in Australia and The Netherlands. Method We analysed publicly available government data on outpatient OA dispensing over 15 years (2000-2014). We compared dispensing trends for specific OA and explored medical (national clinical guidelines), contextual and policy-related factors to explain differences in use between the two countries...
June 12, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/28604488/anterior-cervical-discectomy-and-fusion-outcomes-over-10-years-a-prospective-study
#5
Glenn R Buttermann
STUDY DESIGN: Prospective cohort study with >10-year follow-up. OBJECTIVE: To assess the long-term, >10-year, clinical outcomes of anterior cervical discectomy and fusion (ACDF) and to compare outcomes based on primary diagnosis of disc herniation; stenosis or advanced degenerative disc disease (DDD); number of levels treated; and preexisting adjacent level degeneration. SUMMARY OF BACKGROUND DATA: ACDF is a proven treatment for patients with stenosis and disc herniation and results in significantly improved short- and intermediate-term outcomes...
June 9, 2017: Spine
https://www.readbyqxmd.com/read/28602805/erm-gene-distribution-among-norwegian-bacteroides-isolates-and-evaluation-of-phenotypic-tests-to-detect-inducible-clindamycin-resistance-in-bacteroides-species
#6
Bjørn Odd Johnsen, Nina Handal, Roger Meisal, Jørgen Vildershøj Bjørnholt, Peter Gaustad, Truls Michael Leegaard
The aims of this study were to describe the distribution of the most common erm genes in a collection of Norwegian Bacteroides isolates and to investigate whether the phenotypic tests for determining inducible clindamycin resistance among Bacteroides species recommended by EUCAST, NordicAST and the manufacturer of E-test(®), are effective. We investigated 175 unique Bacteroides isolates for the presence of erm(B), erm(F) and erm(G) genes, determined their minimum inhibitory concentrations (MICs) to clindamycin and categorised their susceptibility according to EUCAST breakpoints...
June 8, 2017: Anaerobe
https://www.readbyqxmd.com/read/28601418/psenen-mutation-carriers-with-co-manifestation-of-acne-inversa-ai-and-dowling-degos-disease-ddd-is-ai-or-ddd-the-subphenotype
#7
Chengrang Li, Wenrui Li, Haoxiang Xu, Xiaofeng Zhang, Bin Su, Wanlu Zhang, Xue Zhang, Baoxi Wang
No abstract text is available yet for this article.
June 7, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28598895/the-concurrent-use-of-lumbar-total-disc-arthroplasty-and-anterior-lumbar-interbody-fusion-the-lumbar-hybrid-procedure-for-the-treatment-of-multi-level-symptomatic-degenerative-disc-disease-a-prospective-study
#8
Matthew Scott-Young, Laurence McEntee, Ben Schram, Evelyne Rathbone, Wayne Hing, David Nielsen
STUDY DESIGN: A prospective study. OBJECTIVE: The aim of this paper is to evaluate clinical and patient outcomes post combined Total Disc Arthroplasty (TDA) and Anterior Lumbar Interbody Fusion (ALIF), known as hybrid surgery for the treatment of multi-level symptomatic degenerative disc disease (DDD). SUMMARY OF BACKGROUND DATA: Class I studies comparing the treatment of one level lumbar DDD with TDA and ALIF have confirmed the effectiveness of those treatments through clinical and patient outcomes...
June 8, 2017: Spine
https://www.readbyqxmd.com/read/28593643/did-the-affordable-care-act-s-dependent-coverage-expansion-affect-race-ethnic-disparities-in-health-insurance-coverage
#9
Joshua Breslau, Bing Han, Bradley D Stein, Rachel M Burns, Hao Yu
OBJECTIVE: To test the impact of the dependent coverage expansion (DCE) on insurance disparities across race/ethnic groups. DATA SOURCES/STUDY SETTING: Survey data from the National Survey of Drug Use and Health (NSDUH). STUDY DESIGN: Triple-difference (DDD) models were applied to repeated cross-sectional surveys of the U.S. adult population. DATA COLLECTION/EXTRACTION METHODS: Data from 6 years (2008-2013) of the NSDUH were combined...
June 8, 2017: Health Services Research
https://www.readbyqxmd.com/read/28593446/c3-glomerulonephritis-with-a-severe-crescentic-phenotype
#10
Aishwarya Ravindran, Fernando C Fervenza, Richard J H Smith, Sanjeev Sethi
BACKGROUND: C3 glomerulopathy (C3G) is rare type of glomerulonephritis resulting from the glomerular deposition of C3 due to dysregulation of the alternative pathway of complement. It is further subdivided into C3 glomerulonephritis (C3GN) and dense deposit disease (DDD), depending on the ultrastructural features. C3GN usually presents with a membranoproliferative pattern of injury. Crescents may or may not be present. However, we have noted a severe necrotizing and crescentic glomerulonephritis in a small subset of C3GN patients...
June 7, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/28590147/screening-of-cardiovascular-risk-factors-in-patients-with-schizophrenia-and-patients-treated-with-antipsychotic-drugs-are-we-equally-exhaustive-as-with-the-general-population
#11
Miguel Castillo-Sánchez, Mireia Fàbregas-Escurriola, Daniel Bergè-Baquero, MªIsabel Fernández-SanMartín, Albert Goday-Arno
Many studies have previously shown increased cardiovascular risk factors related to schizophrenia independently from the use of antipsychotic drugs. However, a poorer effort in clinical detection and management of cardiovascular risk in patients with severe mental illness could also explain these results. To test this hypothesis, we analyzed the differences in screening and incidence of cardiovascular risk factors between schizophrenia, non-schizophrenic patients on treatment with antipsychotic drugs (NS-TAD) and the general population...
June 7, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28589658/introduction-of-a-drug-detection-dog-programme-in-mental-health-inpatient-units-a-mixed-methods-study-of-consumer-staff-and-carers-perceptions
#12
Samantha M McEvedy, Trentham Furness, Brian McKenna
Many consumers admitted to mental health inpatient units also use illicit drugs, and some continue to do so while receiving treatment. In an attempt to curb the impact of illicit drug use, one of Australia's largest mental health services introduced a programme of drug-detection dog (DDD) searches. Our aim was to evaluate perceptions of the DDD programme among mental health consumers, staff, and carers. A mixed-methods research design using a concurrent triangulation approach was adopted, involving three focus group discussions with consumer, staff, and carer groups, and a structured survey among 94 consumers who were receiving treatment and 102 staff working in the units at the time of a DDD visit...
June 7, 2017: International Journal of Mental Health Nursing
https://www.readbyqxmd.com/read/28582404/drug-class-specific-changes-in-the-volume-and-cost-of-antidiabetic-medications-in-poland-between-2012-and-2015
#13
Andrzej Śliwczyński, Melania Brzozowska, Andrzej Jacyna, Petre Iltchev, Tymoteusz Iwańczuk, Waldemar Wierzba, Michał Marczak, Katarzyna Orlewska, Piotr Szymański, Ewa Orlewska
AIM: to investigate the drug-class-specific changes in the volume and cost of antidiabetic medications in Poland in 2012-2015. METHODS: This retrospective analysis was conducted based on the National Health Fund database covering an entire Polish population. The volume of antidiabetic medications is reported according to ATC/DDD methodology, costs-in current international dollars, based on purchasing power parity. RESULTS: During a 4-year observational period the number of patients, consumption of antidiabetic drugs and costs increased by 17%, 21% and 20%, respectively...
2017: PloS One
https://www.readbyqxmd.com/read/28579697/hydrodynamically-driven-drug-release-during-interstitial-flow-through-hollow-fibers-implanted-near-lymphatics
#14
Stanislav S Dukhin, Mohamed E Labib
Current drug delivery devices (DDD) are mainly based on the use of diffusion as the main transport process. Diffusion-driven processes can only achieve low release rate because diffusion is a slow process. This represents a serious obstacle in the realization of recent successes in the suppression of lymphatic metastasis and in the prevention of limb and organ transplant rejection. Surprisingly, it was overlooked that there is a more favorable drug release mode which can be achieved when a special DDD is implanted near lymphatics...
May 20, 2017: Colloids and Surfaces. A, Physicochemical and Engineering Aspects
https://www.readbyqxmd.com/read/28573137/rituximab-for-treatment-of-membranoproliferative-glomerulonephritis-and-c3-glomerulopathies
#15
REVIEW
Michael Rudnicki
Membranoproliferative glomerulonephritis (MPGN) is a histological pattern of injury resulting from predominantly subendothelial and mesangial deposition of immunoglobulins or complement factors with subsequent inflammation and proliferation particularly of the glomerular basement membrane. Recent classification of MPGN is based on pathogenesis dividing MPGN into immunoglobulin-associated MPGN and complement-mediated C3 glomerulonephritis (C3GN) and dense deposit disease (DDD). Current guidelines suggest treatment with steroids, cytotoxic agents with or without plasmapheresis only for subjects with progressive disease, that is, nephrotic range proteinuria and decline of renal function...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28567490/ventricular-rate-stabilization-for-treatment-of-recurrent-vt
#16
REVIEW
Mate Vamos, Peter Bogyi, Gabor Z Duray, Noemi Nyolczas, Stefan H Hohnloser
A patient with ischaemic cardiomyopathy received a secondary prevention VVI implantable cardioverter-defibrillator (ICD) after an episode of sustained ventricular tachycardia (VT). Because of recurrent VTs transmitted via CareLink, medical therapy was optimized and VT ablation was performed. Subsequently, a fast VT with a typical short-long-short initiation developed. In addition, there was an increasing need for ventricular pacing due to sinus bradycardia. This new type of VT could be successfully dealt with by upgrading to DDD ICD and activating the Ventricular Rate Stabilization algorithm...
May 31, 2017: Herzschrittmachertherapie & Elektrophysiologie
https://www.readbyqxmd.com/read/28554927/systemic-glucocorticoid-use-in-denmark-a-population-based-prevalence-study
#17
Kristina Laugesen, Jens Otto Lunde Jørgensen, Henrik Toft Sørensen, Irene Petersen
OBJECTIVES: Glucocorticoid (GC) use is widespread and associated with many adverse effects. Thus, it is important to ascertain GC utilisation patterns. In this study, we examined the annual prevalence of prescription users and amount of use of systemic GCs. DESIGN: Population-wide prevalence study. SETTING: The primary healthcare and hospital sectors in Denmark from 1999 to 2015. RESULTS: Approximately 3% of the Danish population redeemed at least one prescription for a systemic GC annually between 1999 and 2015, with annual prevalence remaining constant over the period...
May 29, 2017: BMJ Open
https://www.readbyqxmd.com/read/28542275/combination-of-the-immunization-with-the-sequence-close-to-the-consensus-sequence-and-two-dna-prime-plus-one-vlp-boost-generate-h5-hemagglutinin-specific-broad-neutralizing-antibodies
#18
Guiqin Wang, Renfu Yin, Paul Zhou, Zhuang Ding
Hemagglutinin (HA) head has long been considered to be able to elicit only a narrow, strain-specific antibody response as it undergoes rapid antigenic drift. However, we previously showed that a heterologous prime-boost strategy, in which mice were primed twice with DNA encoding HA and boosted once with virus-like particles (VLP) from an H5N1 strain A/Thailand/1(KAN)-1/2004 (noted as TH DDV), induced anti-head broad cross-H5 neutralizing antibody response. To explain why TH DDV immunization could generate such breadth, we systemically compared the neutralization breadth and potency between TH DDV sera and immune sera elicited by TH DDD (three times of DNA immunizations), TH VVV (three times of VLP immunizations), TH DV (one DNA prime plus one VLP boost) and TK DDV (plasmid DNA and VLP derived from another H5N1 strain, A/Turkey/65596/2006)...
2017: PloS One
https://www.readbyqxmd.com/read/28540444/organochlorine-pesticides-residues-in-human-breast-milk-from-the-middle-governorates-in-jordan-in-2013-2014
#19
Tawfiq M Al Antary, Mahmoud A Alawi, Hussein Estityah, Nizar Haddad
One hundred samples of mother breast milk were gathered from six middle governorates and districts in Jordan in 2013/2014 to monitor Organochlorine pesticides pollutants. The results showed clearly that banned organochlorine pesticides are still detected in the monitored samples in low concentration despite banning of these persistent pollutants in Jordan since 36 years ago. However, the results indicated that 1% of the contaminated samples contained β-HCH, 5% γ-HCH, 3% p,p'-DDD, 2% heptachlor, 45% p,p'-DDE and 3% p,p'-DDT...
May 24, 2017: Bulletin of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28536421/assessment-of-tissue-specific-accumulation-elimination-and-toxic-effects-of-dichlorodiphenyltrichloroethanes-ddts-in-carp-through-aquatic-food-web
#20
Shanshan Di, Ruiquan Liu, Zhongnan Tian, Cheng Cheng, Li Chen, Wenjun Zhang, Zhiqiang Zhou, Jinling Diao
Microcosms containing DDT spiked-sediment, Tubifex tubifex and carp (Cyprinus carpio) were constructed to simulate a freshwater system. The accumulation, elimination and toxic effects of DDT (p,p'-DDT, o,p'-DDT), and its metabolites DDD (p,p'-DDD, o,p'-DDD) and DDE (p,p'-DDE, o,p'-DDE) were studied in T. tubifex and carp. Tissue/organ distributions of DDTs were also investigated in carp. The bioaccumulation and elimination of DDT differed in T. tubifex, carp and its tissues/organs. Unimodal or bimodal distributions were observed, and the concentrations of DDT metabolites (DDD and p,p'-DDE) increased over time...
May 23, 2017: Scientific Reports
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