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https://www.readbyqxmd.com/read/29772028/randomized-phase-i-trial-hiv-core-003-depletion-of-serum-amyloid-p-component-and-immunogenicity-of-dna-vaccination-against-hiv-1
#1
Nicola J Borthwick, Thirusha Lane, Nathifa Moyo, Alison Crook, Jung Min Shim, Ian Baines, Edmund G Wee, Philip N Hawkins, Julian D Gillmore, Tomáš Hanke, Mark B Pepys
BACKGROUND: The failure of DNA vaccination in humans, in contrast to its efficacy in some species, is unexplained. Observational and interventional experimental evidence suggests that DNA immunogenicity may be prevented by binding of human serum amyloid P component (SAP). SAP is the single normal DNA binding protein in human plasma. The drug (R)-1-[6-[(R)-2-carboxypyrrolidin-1-yl]-6-oxo-hexanoyl]pyrrolidine-2-carboxylic acid (CPHPC, miridesap), developed for treatment of systemic amyloidosis and Alzheimer's disease, depletes circulating SAP by 95-99%...
2018: PloS One
https://www.readbyqxmd.com/read/29765241/prevalence-of-antibiotic-prescription-in-southern-italian-outpatients-real-world-data-analysis-of-socioeconomic-and-sociodemographic-variables-at-a-municipality-level
#2
Veronica Russo, Valeria Marina Monetti, Francesca Guerriero, Ugo Trama, Antonella Guida, Enrica Menditto, Valentina Orlando
Purpose: The aim of this study was to analyze the geographic variation in systemic antibiotic prescription at a regional level and to explore the influence of socioeconomic and sociodemographic variables. Methods: This study was a retrospective analysis of reimbursement pharmacy records in the outpatient settings of Italy's Campania Region in 2016. Standardized antibiotic prescription rates were calculated at municipality and Local Health Unit (LHU) level. Antibiotic consumption was analyzed as defined daily doses (DDD)/1000 inhabitants per day (DID)...
2018: ClinicoEconomics and Outcomes Research: CEOR
https://www.readbyqxmd.com/read/29762112/lumbar-discography-is-associated-with-poor-return-to-work-status-following-lumbar-fusion-surgery-in-a-workers-compensation-setting
#3
Joshua T Anderson, Jeffrey A O'Donnell, Arnold R Haas, Rick Percy, Stephen T Woods, Uri M Ahn, Nicholas U Ahn
Lumbar discography (LD) is used to guide surgical decision making in patients with degenerative disc disease (DDD). Its safety and diagnostic accuracy are under contention. This study evaluates LD's efficacy within the workers' compensation (WC) population. Multivariate logistic regression analysis was used to determine the impact that undergoing LD before lumbar fusion for DDD had on return to work (RTW) rates among 1407 WC subjects. Discography was negatively associated with RTW status (p = .042; OR 0.76); 22...
2018: Journal of Surgical Orthopaedic Advances
https://www.readbyqxmd.com/read/29760929/statin-associated-myopathy-assessment-of-frequency-based-on-data-of-all-statutory-health-insurance-funds-in-germany
#4
Peter Ihle, Franz-Werner Dippel, Ingrid Schubert
Aim of the study was to assess the incidence of statin-associated myopathy (SAM) under real-life conditions in Germany. DATABASE: Administrative data (master data, diagnoses, prescriptions) for all individuals in Germany insured with the Statutory Health Insurance. Basic population: individuals 18 years and older who have been insured continually from 2009 to 2011 (52.9 million; 29.9 million men, 23.9 million women). Data access is provided by the German Institute of Medical Documentation and Information, DIMDI) according to the Data Transparency Regulation of 2012...
June 2018: Pharmacology Research & Perspectives
https://www.readbyqxmd.com/read/29744125/a-rare-case-of-pacemaker-induced-tachycardia-in-an-elderly-woman-with-cor-triatriatum-sinistrum
#5
Nicoleta Cornelia Mirescu, Lucian Mureşan, Anca Daniela Farcaş
Pacemaker induced tachycardia (PIT) is a rare iatrogenic rhythm disorder which tipically occurs in patients with dual-chamber pacemakers and has different causes, including oversensing of atrial tachyarrhythmia waves. Cor triatriatum sinistrum is a congenital abnormality infrequent in adults, associated with a high risk of atrial tachyarrhythmia. We present the case of a 80-year-old woman incidentally diagnosed with cor triatriatum sinistrum echocardiographycally, implanted with a DDD pacemaker for sinus node disease, who developed atrial tachyarrhythmia (paroxysmal atrial fibrillation and left atrial tachycardia), which triggered a PIT, successfully aborted by automatic mode switch...
August 2017: Oxford Medical Case Reports
https://www.readbyqxmd.com/read/29740699/de-novo-mutations-in-med13-a-component-of-the-mediator-complex-are-associated-with-a-novel-neurodevelopmental-disorder
#6
Lot Snijders Blok, Susan M Hiatt, Kevin M Bowling, Jeremy W Prokop, Krysta L Engel, J Nicholas Cochran, E Martina Bebin, Emilia K Bijlsma, Claudia A L Ruivenkamp, Paulien Terhal, Marleen E H Simon, Rosemarie Smith, Jane A Hurst, Heather McLaughlin, Richard Person, Amy Crunk, Michael F Wangler, Haley Streff, Joseph D Symonds, Sameer M Zuberi, Katherine S Elliott, Victoria R Sanders, Abigail Masunga, Robert J Hopkin, Holly A Dubbs, Xilma R Ortiz-Gonzalez, Rolph Pfundt, Han G Brunner, Simon E Fisher, Tjitske Kleefstra, Gregory M Cooper
Many genetic causes of developmental delay and/or intellectual disability (DD/ID) are extremely rare, and robust discovery of these requires both large-scale DNA sequencing and data sharing. Here we describe a GeneMatcher collaboration which led to a cohort of 13 affected individuals harboring protein-altering variants, 11 of which are de novo, in MED13; the only inherited variant was transmitted to an affected child from an affected mother. All patients had intellectual disability and/or developmental delays, including speech delays or disorders...
May 8, 2018: Human Genetics
https://www.readbyqxmd.com/read/29730381/timeliness-in-the-notification-of-spotted-fever-in-brazil-evaluating-compulsory-reporting-strategies-and-digital-disease-detection
#7
Stefan Vilges de Oliveira, Rodrigo Nogueira Angerami
Spotted fever caused by rickettsial species, the most important tick-borne disease. In Brazil, is nationwide communicable compulsory disease to the Ministry of Health. Since 2007, all suspected cases of spotted fever have been integrated into the Notifiable Diseases Information System (SINAN). In this descriptive study we evaluate the timeliness (expressed in number of days between time of clinical suspicion and reporting) of the compulsory notification of spotted fever cases in SINAN and the strategy for digital disease detection (DDD)...
May 3, 2018: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29724214/multiple-challenges-of-antibiotic-use-in-a-large-hospital-in-ethiopia-a-ward-specific-study-showing-high-rates-of-hospital-acquired-infections-and-ineffective-prophylaxis
#8
Girma Gutema, Helle Håkonsen, Ephrem Engidawork, Else-Lydia Toverud
BACKGROUND: This project aims to study the use of antibiotics in three clinical wards in the largest tertiary teaching hospital in Ethiopia for a period of 1 year. The specific aims were to assess the prevalence of patients on antibiotics, quantify the antibiotic consumption and identify the main indications of use. METHOD: The material was all the medical charts (n = 2231) retrieved from three clinical wards (internal medicine, gynecology/obstetrics and surgery) in Tikur Anbessa Specialized Hospital (TASH) in Addis Ababa between September 2013 and September 2014...
May 3, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29724182/favorable-effect-of-bortezomib-in-dense-deposit-disease-associated-with-monoclonal-gammopathy-a-case-report
#9
Shuma Hirashio, Ayaka Satoh, Takahiro Arima, Kouichi Mandai, Tadasuke Awaya, Kumi Oshima, Shigeo Hara, Takao Masaki
BACKGROUND: Complement component 3 (C3) glomerulopathy, which includes dense deposit disease (DDD) and C3 glomerulonephritis, is caused by dysregulation of the alternative complement pathway. In most cases, C3 glomerulopathy manifests pathologically with membranoproliferative glomerulonephritis-like features. An association between C3 glomerulopathy and monoclonal gammopathy was recently reported in several cases, raising the possibility that C3 glomerulopathy is the underlying pathological process in monoclonal gammopathy of renal significance...
May 3, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29723230/consumption-of-antibiotics-in-chinese-public-general-tertiary-hospitals-2011-2014-trends-pattern-changes-and-regional-differences
#10
Xiaoyuan Qu, Chang Yin, Xihong Sun, Shusheng Huang, Chaofan Li, Panpan Dong, Xiufang Lu, Zhuo Zhang, Aitian Yin
BACKGROUND: China has a high rate of antibiotic use. The Chinese Ministry of Health (MOH) established the Center for Antibacterial Surveillance (CAS) to monitor the use of antibacterial agents in hospitals in 2005. The purpose of this study was to identify trends, pattern changes and regional differences in antibiotic consumption in 151 public general tertiary hospitals across China from 2011-2014. MATERIALS AND METHODS: Valid data for antibiotic use were collected quarterly, and the antibiotic consumption data were expressed as the defined daily dose (DDD) per 100 inpatient days (ID)...
2018: PloS One
https://www.readbyqxmd.com/read/29709550/is-the-behavior-of-disc-replacement-adjacent-to-fusion-affected-by-the-location-of-the-fused-level-in-hybrid-surgery
#11
Ting-Kui Wu, Yang Meng, Bei-Yu Wang, Ying Hong, Xin Rong, Chen Ding, Hua Chen, Hao Liu
BACKGROUND: Context: Hybrid surgery (HS), consisting of cervical disc arthroplasty (CDA) at the mobile level, along with anterior cervical discectomy and fusion (ACDF) at the spondylotic level, could be a promising treatment for patients with multilevel cervical degenerative disc disease (DDD). An advantage of this technique is that it utilizes an optimal procedure according to the status of each level. However, information is lacking regarding the influence of the relative location of the replacement and the fusion segment in vivo...
April 27, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29706889/variation-in-antiosteoporotic-drug-prescribing-and-spending-across-spain-a-population-based-ecological-cross-sectional-study
#12
Gabriel Sanfélix-Gimeno, Julián Librero-López, Gracia Modroño-Riaño, Salvador Peiró, Clara L Rodríguez-Bernal
Introduction: Evidence has shown that utilization of antiosteoporotic medications does not correspond with risk, and studies on other therapies have shown that adequacy of pharmaceutical prescribing might vary between regions. Nevertheless, very few studies have addressed the variability in osteoporotic drug consumption. We aimed to describe variations in pharmaceutical utilization and spending on osteoporotic drugs between Health Areas (HA) in Spain. Methods: Population-based cross-sectional ecological study of expenditure and utilization of the five therapeutic groups marketed for osteoporosis treatment in Spain in 2009...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29703463/widespread-increase-of-empirical-carbapenem-use-in-acute-care-hospitals-in-catalonia-spain
#13
Santiago Grau, Esther Fondevilla, Daniel Echeverría-Esnal, Amaia Alcorta, Enric Limon, Francesc Gudiol
INTRODUCTION: The overall increase in the use of carbapenems could lead to the selection of carbapenem-resistant bacteria. The objectives of this study were to analyze carbapenem use from 2008 to 2015 and their prescription profile in 58 hospitals affiliated to the VINCat Programme (nosocomial infection vigilance system). METHODS: Retrospective, longitudinal and descriptive study of carbapenem use. Consecutive case-series study, looking for carbapenem prescription characteristics, conducted in January 2016...
April 24, 2018: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/29702308/unilateral-veral-pedicle-screw-fixation-combined-with-transforaminal-lumbar-interbody-fusion-rsus-bilatefor-the-treatment-of-low-lumbar-degenerative-disc-diseases-analysis-of-clinical-and-radiographic-results
#14
De-Jian Chen, Cong Yao, Quanwei Song, Benyu Tang, Xuqiang Liu, Bin Zhang, Min Dai, Tao Nie, Zongmiao Wan
OBJECTIVE: Our objective was to compare the clinical and radiographic results of unilateral pedicle screw fixation (UPSF) and bilateral pedicle screw fixation (BPSF) after unilateral transforaminal lumbar interbody fusion (TLIF) for the treatment of lumbar degenerative disc diseases (DDD). MATERIALS AND METHODS: 63 patients who underwent UPSF or BPSF combined with unilateral TLIF at L4-L5 or L5-S1 were included in our hospital from 2014-2016. The perioperative outcomes and radiographic results were recorded at preoperative and postoperative follow-up...
April 24, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29698805/extending-the-clinical-and-genetic-spectrum-of-arid2-related-intellectual-disability-a-case-series-of-7-patients
#15
Gabriella Gazdagh, Moira Blyth, Ingrid Scurr, Peter D Turnpenny, Sarju G Mehta, Ruth Armstrong, Meriel McEntagart, Ruth Newbury-Ecob, Edward S Tobias, Shelagh Joss
In the last 3 years de novo sequence variants in the ARID2 (AT-rich interaction domain 2) gene, a subunit of the SWI/SNF complex, have been linked to intellectual disabilities in 3 case reports including one which describes frameshift mutations in ARID2 in 2 patients with features resembling Coffin-Siris syndrome. Coffin-Siris syndrome (CSS) is a rare congenital syndrome characterized by intellectual deficit, coarse facial features and hypoplastic or absent fifth fingernails and/or toenails among other features...
April 23, 2018: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/29695481/anticholinergic-drugs-and-risk-of-dementia-case-control-study
#16
Kathryn Richardson, Chris Fox, Ian Maidment, Nicholas Steel, Yoon K Loke, Antony Arthur, Phyo K Myint, Carlota M Grossi, Katharina Mattishent, Kathleen Bennett, Noll L Campbell, Malaz Boustani, Louise Robinson, Carol Brayne, Fiona E Matthews, George M Savva
OBJECTIVES: To estimate the association between the duration and level of exposure to different classes of anticholinergic drugs and subsequent incident dementia. DESIGN: Case-control study. SETTING: General practices in the UK contributing to the Clinical Practice Research Datalink. PARTICIPANTS: 40 770 patients aged 65-99 with a diagnosis of dementia between April 2006 and July 2015, and 283 933 controls without dementia...
April 25, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29681108/functional-mrna-analysis-reveals-aberrant-splicing-caused-by-novel-intronic-mutation-in-wdr45-in-nbia-patient
#17
Josh Willoughby, Celia Duff-Farrier, Archana Desurkar, Manju Kurian, Ashok Raghavan, Meena Balasubramanian
WDR45 gene-associated neurodegeneration with brain iron accumulation (NBIA), referred to as beta-propeller protein-associated neurodegeneration (BPAN), is a rare disorder that presents with a very nonspecific clinical phenotype in children constituting global developmental delay. This case report illustrates the power of a combination of trio exome sequencing, in silico splicing analysis, and mRNA analysis to provide sufficient evidence for pathogenicity of a relatively intronic variant in WDR45, and in so doing, find a genetic diagnosis for a 6-year-old patient with developmental delay and seizures, a diagnosis which may otherwise have only been found once the characteristic MRI patterns of the disease became more obvious in young adulthood...
May 2018: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/29681091/expanding-the-molecular-basis-and-phenotypic-spectrum-of-zdhhc9-associated-x-linked-intellectual-disability
#18
Schaida Schirwani, Emma Wakeling, Kath Smith, Meena Balasubramanian
Pathogenic variants in Zinc Finger DHHC-Type Containing 9 (ZDHHC9) gene have been identified as the cause of X-linked intellectual disability (XLID) in a small number of families. There are a total of 11 reported pathogenic variants in ZDHHC9 in the literature. The majority of reported variants are familial point mutations. There is one report of XLID associated with a de novo mutation in ZDHHC9, and one family with intragenic deletion within ZDHHC9 detected by array CGH. Although initial reports of families with ZDHHC9 pathogenic variants suggested a nonsyndromic XLID, more recent reports suggest a syndromic phenotype with facial dysmorphism...
May 2018: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/29679846/biodegradability-and-ecological-safety-assessment-of-stenotrophomonas-sp-ddt-1-in-the-ddt-contaminated-soil
#19
Hua Fang, Yanfei Deng, Qiqing Ge, Jiajia Mei, Houpu Zhang, Huifang Wang, Yunlong Yu
The biodegradability and ecological safety assessment of the previously isolated DDT-degrading bacterial strain Stenotrophomonas sp. DDT-1 were investigated in the DDT-contaminated soil under laboratory and field conditions. Under laboratory conditions, the degradation rates of fresh p,p'-DDT in soil were enhanced by 2.0-3.0-fold with the introduction of the strain DDT-1 compared to those of the control treatments. A similar enhancement in the dissipation of DDTs (p,p'-DDT, p,p'-DDE, p,p'-DDD, and o,p'-DDT) in the aged DDT-contaminated field plot soils resulted from the inoculation with this strain...
April 18, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29671108/comparison-of-pure-lateral-and-oblique-lateral-inter-body-fusion-for-treatment-of-lumbar-degenerative-disk-disease-a-multicentric-cohort-study
#20
Massimo Miscusi, Alessandro Ramieri, Stefano Forcato, Mary Giuffrè, Sokol Trungu, Marco Cimatti, Alessandro Pesce, Pietro Familiari, Amedeo Piazza, Cristina Carnevali, Giuseppe Costanzo, Antonino Raco
PURPOSE: The most effective interbody fusion technique for degenerative disk disease (DDD) is still controversial. The purpose of our study is to compare pure lateral (LLIF) and oblique lateral (OLIF) approaches for the treatment of lumbar DDD from L1-L2 to L4-L5, in terms of clinical and radiological outcomes. MATERIALS AND METHODS: 45 patients underwent lumbar interbody fusion for pure lumbar DDD from  L1-L2 to L4-L5 through LLIF (n = 31, mean age 62.1 years, range 45-78 years) or OLIF (n = 14, mean age 57...
April 18, 2018: European Spine Journal
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