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https://www.readbyqxmd.com/read/28434213/evaluation-of-the-synergistic-effect-of-mixed-cultures-of-white-rot-fungus-pleurotus-ostreatus-and-biosurfactant-producing-bacteria-on-ddt-biodegradation
#1
Adi Setyo Purnomo, Khoirul Ashari, Farizha Triyogi Hermansyah
DDT (1,1,1-trichloro-2,2-bis(4-chlorophenyl) ethane) is one of the organic synthetic pesticides that has many negative effects for human health and the environment. The purpose of this study was to investigate the synergistic effect of mixed cutures of white-rot fungus, Pleurotus ostreatus, and biosurfactant-producing bacteria, Pseudomonas aeruginosa and Bacillus subtilis, on DDT biodegradation. Bacteria was added into P. ostreatus culture (mycelial wet weight on average by 8.53 g) in concentrations of 1, 3, 5, and 10 mL (1 mL ≈ 1...
April 21, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28434068/assessment-of-ddt-and-metabolites-in-soil-and-sediment-of-potentially-contaminated-areas-of-bel%C3%A3-m-amazon-region-brazil
#2
Andreia Oliveira Rodrigues, Larissa Costa de Souza, Cássia Christina da Silva Rocha, Amilton Cesar Gomes da Costa, Rosivaldo de Alcântara Mendes
The aim of this study was to evaluate the distribution of DDT and metabolites in surface soils and soil profiles from two areas containing deposits of obsolete pesticides in Belém, Amazon Region, Brazil. DDT and metabolites were extracted by microwave assisted extraction and analyzed by gas chromatography with electron capture detection. Concentrations of total DDT in surface soil samples ranged from 64.22 mg kg(-1) in area 1 (A1) to 447.84 mg kg(-1) in area 2 (A2). Lower levels were found in soil profiles than at the surface (6...
April 22, 2017: Bulletin of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28433838/outcome-of-anterior-lumbar-interbody-fusion-a-retrospective-study-of-clinical-and-radiological-parameters
#3
H Pinson, G Hallaert, P Herregodts, K Everaert, T Couvreur, J Caemaert, J P Kalala, D Van Roost
OBJECTIVE: This study aims to critically evaluate the long-term results of stand-alone anterior lumbar interbody fusion (ALIF), without use of rhBMP-2, as a therapeutic option for symptomatic patients with degenerative disc disease (DDD). Furthermore this study intends to identify predictive parameters for anterior lumbar interbody fusion outcome. METHODS: A retrospective cohort study with additional telephone interview to obtain missing data was performed. All patients who underwent a L4-L5 and/or L5-S1 ALIF-procedure in the period between 2006 and 2011 were identified...
April 19, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28432879/seasonal-variation-and-health-risk-assessment-of-organochlorine-compounds-in-urban-soils-of-novi-sad-serbia
#4
Biljana D Škrbić, Vesna Marinković, Igor Antić, Anita Petrović Gegić
The aim of this paper was to determine spatial and seasonal variation of 6 indicator polychlorinated biphenyls (PCBs) and 18 organochlorine pesticides (OCPs) in urban soils of Novi Sad, Serbia. Sixty surface soil samples were collected during both winter and summer season, from different types of locations: schools, recreational areas, residential and industrial zones. Samples were treated using the method of accelerated solvent extraction, which allows simultaneous extraction and clean up of PCBs and OCPs...
April 15, 2017: Chemosphere
https://www.readbyqxmd.com/read/28432798/therapeutic-drug-monitoring-of-mitotane-analytical-assay-and-patient-follow-up
#5
Yoann Cazaubon, Helene Guillemin, Damien Vautier, Olivier Oget, Hervé Millart, Claire Gozalo, Zoubir Djerada, Catherine Feliu
BACKGROUND: Adrenocortical carcinoma (ACC) is an aggressive malignancy of the adrenal gland. Mitotane (o,p'-DDD) is the most effective chemotherapy for ACC. According to literature, mitotane plasma trough concentrations within 14-20 mg.L(1) are correlated with a higher response rate with acceptable toxicity. Therapeutic drug monitoring (TDM) of mitotane is therefore recommended. The aim of this study was to propose a robust, and simple method for mitotane quantification in plasma. The validation procedures were based on international guidelines...
April 22, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28431805/lumbar-disc-degeneration-progression-in-young-women-in-their-20-s-a-prospective-ten-year-follow-up
#6
Hiroto Makino, Yoshiharu Kawaguchi, Shoji Seki, Masato Nakano, Taketoshi Yasuda, Kayo Suzuki, Shiro Ikegawa, Tomoatsu Kimura
BACKGROUND: Lumbar disc degeneration (LDD) is known to be the main cause of low back pain, although it is unclear how or when LDD progresses. The purpose of this study was to clarify the process and features of LDD progression in young women. METHODS: We enrolled 480 nursing students and carried out a prospective cohort study in 84 nursing students. MRI of the lumbar spine was taken once during their time as a student and again at 9.8 years (7-14) after the first MRI when they were working as nurses...
April 18, 2017: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/28422521/different-approaches-to-the-assessment-of-adherence-and-persistence-with-cardiovascular-disease-preventive-medications
#7
Sara Malo, Isabel Aguilar-Palacio, Cristina Feja, María Jesús Lallana, María José Rabanaque, Javier Armesto, Enrica Menditto
OBJECTIVE: To assess suitability and comparability of the most common methods of treatment adherence and persistence assessment, as applied to the same pharmacy dataset. METHODS: Data on drugs prescribed for cardiovascular primary prevention to participants in the Aragon Workers' Health Study (AWHS) were collected from a regional electronic drug prescription database. Several different approaches were used to measure treatment adherence (with the Medication Possession Ratio [MPR]) and Proportion of Days Covered [PDC]) and persistence in new users by therapeutic subgroup...
April 19, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28421991/patterns-in-use-and-costs-of-conventional-and-biologic-disease-modifying-anti-rheumatic-drugs-in-australia
#8
Ellen Donges, Christine Staatz, Helen Benham, Paul Kubler, Samantha A Hollingworth
OBJECTIVES: The aim of this study was to characterise the use and costs of subsidising conventional disease-modifying anti-rheumatic drugs (DMARDs) and biologic DMARDs in Australia from 2004-2014 through pharmaceutical benefits schemes. METHODS: Dispensing and expenditure data on conventional and biologic DMARDs were extracted from Medicare Australia and temporal trends were analysed. Medicine use was standardised in terms of the defined daily dose (DDD) per 1,000 population per day (DDD/1,000 population/day)...
April 18, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28407148/effects-of-closed-loop-stimulation-vs-ddd-pacing-on-haemodynamic-variations-and-occurrence-of-syncope-induced-by-head-up-tilt-test-in-older-patients-with-refrac-tory-cardioinhibitory-vasovagal-syncope-the-tilt-test-induced-response-in-closed-loop-stimulation
#9
Pietro Palmisano, Gabriele Dell'Era, Vincenzo Russo, Maria Zaccaria, Rolando Mangia, Miriam Bortnik, Federica De Vecchi, Ailia Giubertoni, Fabiana Patti, Andrea Magnani, Gerardo Nigro, Anna Rago, Eraldo Occhetta, Michele Accogli
Aims: Closed-loop stimulation (CLS) seemed promising in preventing the recurrence of vasovagal syncope (VVS) in patients with a cardioinhibitory response to head-up tilt test (HUTT) compared with conventional pacing. We hypothesized that the better results of this algorithm are due to its quick reaction in high-rate pacing delivered in the early phase of vasovagal reflex, which increase the cardiac output and the blood pressure preventing loss of consciousness. Methods and results: This prospective, randomized, single-blind, multicentre study was designed as an intra-patient comparison and enrolled 30 patients (age 62...
April 12, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28398504/degenerative-inter-vertebral-disc-disease-osteochondrosis-intervertebralis-in-europe-prevalence-geographic-variation-and-radiological-correlates-in-men-and-women-aged-50-and-over
#10
Gabriele Armbrecht, Dieter Felsenberg, Melanie Ganswindt, Mark Lunt, Stephen K Kaptoge, Klaus Abendroth, Antonio Aroso Dias, Ashok K Bhalla, Jorge Cannata Andia, Jan Dequeker, Richard Eastell, Krzysztof Hoszowski, George Lyritis, Pavol Masaryk, Joyce van Meurs, Tomasz Miazgowski, Ranuccio Nuti, Gyula Poór, Inga Redlund-Johnell, David M Reid, Helmut Schatz, Christopher J Todd, Anthony D Woolf, Fernando Rivadeneira, Muhammad K Javaid, Cyrus Cooper, Alan J Silman, Terence W O'Neill, Jonathan Reeve
Objectives.: To assess the prevalences across Europe of radiological indices of degenerative inter-vertebral disc disease (DDD); and to quantify their associations with, age, sex, physical anthropometry, areal BMD (aBMD) and change in aBMD with time. Methods.: In the population-based European Prospective Osteoporosis Study, 27 age-stratified samples of men and women from across the continent aged 50+ years had standardized lateral radiographs of the lumbar and thoracic spine to evaluate the severity of DDD, using the Kellgren-Lawrence (KL) scale...
April 7, 2017: Rheumatology
https://www.readbyqxmd.com/read/28396904/prognosis-of-patients-with-implanted-pacemakers-in-4%C3%A2-year-follow-up-impact-of-right-ventricular-pacing-site
#11
K Krzemień-Wolska, A Tomasik, E Nowalany-Kozielska, W Jacheć
BACKGROUND: Pacing remains the method of choice for treatment of cardiac electrical conduction disorders. This study examined the interrelationship between the site of the right ventricular lead tip and patient prognosis in association with other cardiovascular risk factors over a 4‑year follow-up period. PATIENTS AND METHODS: The study comprised 450 consecutive patients (223 women; aged 69.16 ± 9.63 years) who had their first SSI or DDD pacemaker implanted for typical indications...
April 10, 2017: Herz
https://www.readbyqxmd.com/read/28394903/5-alpha-reductase-inhibitor-therapy-postpones-urine-retention-and-prostate-surgery-in-patients-with-prostate-enlargement-and-a-maximum-uroflow-rate-of-less-than-15-ml-sec
#12
Wenhsu Lin, Shangsen Lee, Jengyuan Wu, Yuhung Kuo, Tengfu Hsieh
BACKGROUND: This study investigated the risk of transurethral resection of prostate (TURP) and acute urine retention (AUR) in relation to 5-alpha-reductase inhibitor (5ARI) therapy. METHODS: We identified 22,687 patients who were newly diagnosed with PE and low urinary tract symptoms (LUTS) between January 1, 2002 and December 31, 2011. We further classified study subjects who had moderate to severe LUTS and a maximum uroflow rate of less than 15ml/sec into three groups by their defined daily dose (DDD) of 5ARI used...
2017: PloS One
https://www.readbyqxmd.com/read/28392965/mechanosignaling-activation-of-tgf%C3%AE-maintains-intervertebral-disc-homeostasis
#13
Qin Bian, Lei Ma, Amit Jain, Janet L Crane, Khaled Kebaish, Mei Wan, Zhengdong Zhang, X Edward Guo, Paul D Sponseller, Cheryle A Séguin, Lee H Riley, Yongjun Wang, Xu Cao
Intervertebral disc (IVD) degeneration is the leading cause of disability with no disease-modifying treatment. IVD degeneration is associated with instable mechanical loading in the spine, but little is known about how mechanical stress regulates nucleus notochordal (NC) cells to maintain IVD homeostasis. Here we report that mechanical stress can result in excessive integrin αvβ6-mediated activation of transforming growth factor beta (TGFβ), decreased NC cell vacuoles, and increased matrix proteoglycan production, and results in degenerative disc disease (DDD)...
2017: Bone Research
https://www.readbyqxmd.com/read/28384462/can-a-10-minute-questionnaire-identify-significant-psychological-issues-in-patients-with-temporomandibular-joint-disease
#14
Shang-Lun Lin, Shang-Liang Wu, Hsien-Te Huang, For-Wey Lung, Tzong-Cherng Chi, Jung-Wu Yang
PURPOSES: For patients with disc displacement disorders (DDDs), psychiatric illness increases the risk of worsening postsurgical pain, postoperative delirium, postoperative incomplete recovery, and worse postoperative life quality. This study provides a fast and practical protocol to evaluate psychological conditions of patients with DDDs of the temporomandibular joint (TMJ) in clinical care. MATERIALS AND METHODS: The populations under investigation in this cross-sectional study included patients with DDD who received treatment from October 2012 through June 2016...
March 14, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28382548/study-of-persistent-toxic-pollutants-in-a-river-basin-ecotoxicological-risk-assessment
#15
Evangelia Terzopoulou, Dimitra Voutsa
This study presents a complementary approach for the evaluation of water quality in a river basin by employing active and passive sampling. Persistent toxic pollutants representing three classes: organochlorinated pesticides (OCPs), polychlorinated biphenyls (PCBs) and polycyclic aromatic hydrocarbons (PAHs), were studied in grab water samples, in passive samplers/SemiPermeable Membrane Devices (SPMDs) and in fish tissues collected along the Strymonas River, northern Greece at three sampling campaigns during the year 2013...
April 5, 2017: Ecotoxicology
https://www.readbyqxmd.com/read/28382391/maverick-total-disc-arthroplasty-performs-well-at-10%C3%A2-years-follow-up-a-prospective-study-with-hrql-and-balance-analysis
#16
N Plais, X Thevenot, A Cogniet, J Rigal, J C Le Huec
PURPOSE: The treatment of low back pain associated to Disc Degenerative Disease (DDD) is still controversial. Segmental Fusion is the gold standard, but many studies have reported that motion-preserving devices bring substantial clinical benefits to patients. Concerns on the associated complications and on the long-term clinical effectiveness of such instrumentations are still present and have led recently to a decrease of the number of Lumbar Total Disk Replacements (TDR). The objective of this prospective study is to present the clinical and radiographic outcomes of the Maverick Lumbar disk prostheses (Medtronic, TE, Memphis, USA) at long-term follow-up...
April 5, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28379483/effectiveness-of-prescription-based-cns-stimulants-on-hospitalization-in-patients-with-schizophrenia-a-nation-wide-register-study
#17
Christopher Rohde, Christoffer Polcwiartek, Marton Asztalos, Jimmi Nielsen
OBJECTIVE: Negative symptoms and cognitive deficits are main features of schizophrenia but with limited treatment options. Earlier studies have suggested that central nervous system (CNS) stimulants have a small effect on these domains, but with inconclusive results. As the first study to date, we aimed to investigate whether CNS stimulants improve naturalistic outcomes (psychiatric admissions and antipsychotic use) in patients with schizophrenia. METHODS: By using extensive health registers all patients with schizophrenia and their use of CNS stimulants in Denmark were identified...
April 1, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/28378101/human-y-chromosome-copy-number-variation-in-the-next-generation-sequencing-era-and-beyond
#18
REVIEW
Andrea Massaia, Yali Xue
The human Y chromosome provides a fertile ground for structural rearrangements owing to its haploidy and high content of repeated sequences. The methodologies used for copy number variation (CNV) studies have developed over the years. Low-throughput techniques based on direct observation of rearrangements were developed early on, and are still used, often to complement array-based or sequencing approaches which have limited power in regions with high repeat content and specifically in the presence of long, identical repeats, such as those found in human sex chromosomes...
April 4, 2017: Human Genetics
https://www.readbyqxmd.com/read/28377243/hybrid-bone-spect-ct-imaging-in-evaluation-of-chronic-low-back-pain-correlation-with-modic-changes-and-degenerative-disc-disease
#19
Vittorio M Russo, Ranju T Dhawan, Nishanth Dharmarajah, I Baudracco, Antonio I Lazzarino, Adrian T Casey
BACKGROUND CONTEXT: Multiple radiological modalities are used in the evaluation of patients with low back pain (LBP). Only limited evidence currently exists to support the use of Bone HDP (hydroxydiphosphonate) SPECT/CT (Single Photon Emission Computed Tomography) in patients with Modic changes (MC) and degenerative disc disease (DDD). PURPOSE: The aim of this study was to assess the value of the hybrid Bone SPECT/CT imaging in patients with chronic low back pain...
April 1, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28376780/kinematic-characteristics-of-lumbar-spinous-processes-during-axial-rotation-in-patients-with-lumbar-degenerative-disc-disease-lateral-lumbar-interbody-fusion-and-intervention
#20
BaoLiang Zhang, Wenhan Huang, Hong Xia, Xinglong Feng
BACKGROUND: Data about minimally invasive surgery for the treatment of patients with degenerative disc disease (DDD) has been reported. However, no quantitative knowledge about the biomechanical characteristics of the spinous processes in patients with DDD after operation was reported in the literature. METHODS: Fourteen adult patients with DDD at the L3-4 level were recruited and scanned using computed tomography (CT) to construct three-dimensional (3D) anatomical vertebral models of L2-5...
April 4, 2017: BMC Musculoskeletal Disorders
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