Han-Wool Choung, Dong-Seol Lee, Yeoung-Hyun Park, Yoon Seon Lee, Shengfeng Bai, Su-Hyang Yoo, Jong-Ho Lee, Hyung-Keun You, Joo-Cheol Park
INTRODUCTION: Preameloblast-conditioned medium (PA-CM), as a mixture of dental epithelium-derived factors has been reported to regenerate dentin and periodontal tissues in vitro and in vivo. Recently, protein copine7 (Cpne7) which was found in PA-CM was suggested to have a beneficial role in periodontal tissue healing. The aim of this study was to investigate the biological effect of Cpne7 on the proliferation, migration, and cementoblast differentiation of periodontal cells in vitro, and on the regeneration of periodontal tissue using periodontal defect model with canine in vivo...
February 8, 2019: Connective Tissue Research