keyword
https://read.qxmd.com/read/33826555/histologic-evaluation-of-tibial-attachment-in-11-year-double-bundle-acl-reconstruction-with-hamstring-tendons-a-case-report
#21
JOURNAL ARTICLE
Yuki Okazaki, Nobuhiro Abe, Kimihiko Makiyama, Takayuki Furumatsu, Shinichi Miyazawa, Toshifumi Ozaki
CASE: A 49-year-old woman injured her anterior cruciate ligament (ACL) as a high-school student. Double-bundle ACL reconstruction (DBACLR) using hamstring tendon grafts was performed because of recurrent instability. Eleven years after DBACLR, total knee arthroplasty was performed because of osteoarthritis progression. Histologic analysis was completed to observe the osteointegration of the tendon in the obtained proximal tibia. The tibial tunnel showed Sharpey-like fibers anteriorly, connecting the tendon graft and lamellar bone, whereas the intraarticular exit revealed well-aligned chondrocytes posteriorly, indicating chondral metaplasia of the tendon graft...
April 7, 2021: JBJS Case Connector
https://read.qxmd.com/read/33141598/an-autograft-for-anterior-cruciate-ligament-reconstruction-results-in-better-biomechanical-performance-and-tendon-bone-incorporation-than-does-a-hybrid-graft-in-a-rat-model
#22
JOURNAL ARTICLE
Hong-De Wang, Tian-Rui Wang, Yao Sui, Juan Wang, Wei Chen, Ying-Ze Zhang
BACKGROUND: The biomechanical and tendon-bone incorporation properties of allograft-augmented hybrid grafts for anterior cruciate ligament (ACL) reconstruction compared with traditional autografts are unknown. HYPOTHESIS: Using an autograft for ACL reconstruction yields better results on biomechanical testing, radiographic analysis, and histological evaluation versus using a hybrid graft. STUDY DESIGN: Controlled laboratory study. METHODS: A total of 66 adult male Sprague Dawley rats underwent unilateral ACL reconstruction with an autograft (AT group; n = 33) or a hybrid graft (HB group; n = 33)...
November 3, 2020: American Journal of Sports Medicine
https://read.qxmd.com/read/32715928/porcine-bone-patellar-tendon-bone-xenograft-in-a-caprine-model-of-anterior-cruciate-ligament-repair
#23
JOURNAL ARTICLE
Jared A Lombardi, Amardeep Hoonjan, Neil Rodriguez, Aubrey Delossantos, Gary Monteiro, Maryellen Sandor, Hui Xu
The use of human tissue-derived autografts and allografts continues to be the gold standard in anterior cruciate ligament (ACL) repair. However, autografts and allografts have their own set of associated risks. Many alternative options, including synthetic replacements, have failed to demonstrate long-term success. In this study, sterile acellular porcine bone-tendon-bone (BTB) xenografts were created using a proprietary process and tested against BTB autografts in goats for 13 and 52 weeks. At 13 weeks, all xenograft-implanted animals ( n = 9) had subjective hind leg motor function (HLMF) that was categorized as either normal (score = 0) or a slight limp (score = 1) compared with two of nine autograft-implanted animals having a moderate limp (score = 2)...
January 2020: Journal of Orthopaedic Surgery
https://read.qxmd.com/read/31980897/osteoprotegerin-bone-morphogenetic-protein-2-combining-with-collagen-sponges-on-tendon-bone-healing-in-rabbits
#24
JOURNAL ARTICLE
Bing Wei, Chao Wang, Cheng Yan, Bushun Tang, Xiaofei Yu, Hui Zhang, Lixia Tang, Qing Wang
INTRODUCTION: The aim was to investigate the effect of collagen sponges (CS) as a delivery device for osteoprotegerin (OPG)/bone morphogenetic protein 2 (BMP-2) and support matrix on the tendon-bone healing after anterior crusicate ligament (ACL) reconstruction in modeled rabbits. MATERIALS AND METHODS: Sixty New Zealand white rabbits were randomly divided into four groups based on treatments they received at the tendon-bone interface after left knee ACL reconstruction: the control group, OPG/BMP-2, CS, and OPG/BMP-2/CS combination...
January 24, 2020: Journal of Bone and Mineral Metabolism
https://read.qxmd.com/read/31910231/evaluation-of-a-bioengineered-acl-matrix-s-osteointegration-with-bmp-2-supplementation
#25
JOURNAL ARTICLE
Paulos Y Mengsteab, Patrick Conroy, Mary Badon, Takayoshi Otsuka, Ho-Man Kan, Anthony T Vella, Lakshmi S Nair, Cato T Laurencin
A poly (l-lactic) acid bioengineered anterior cruciate ligament (ACL) matrix has previously demonstrated the ability to support tissue regeneration in a rabbit ACL reconstruction model. The matrix was designed for optimal bone and ligament regeneration by developing a matrix with differential pore sizes in its bone and ligament compartments. Building upon past success, we designed a new bioengineered ACL matrix that is easier to install and can be used with endobutton fixation during ACL reconstruction. To achieve this, a new braiding procedure was developed to allow the matrix to be folded in half, making two-limbs, while maintaining its bone and ligament compartments...
2020: PloS One
https://read.qxmd.com/read/31815969/restorative-emergence-profile-for-single-tooth-implants-in-healthy-periodontal-patients-clinical-guidelines-and-decision-making-strategies
#26
JOURNAL ARTICLE
Stephen J Chu, Joseph Yk Kan, Ernesto A Lee, Guo-Hao Lin, Leila Jahangiri, Myron Nevins, Hom-Lay Wang
The peri-implant soft tissue seal consists of a connective tissue cuff and a junctional epithelium that is different from the arrangement of periodontium around a natural tooth. However, the peri-implant soft tissue complex lacks Sharpey's fibers, thus offering less resistance to clinical probing and biofilm penetration compared to the natural dentition. Therefore, the proper restorative emergence profile design is essential to facilitate favorable esthetic outcomes and maintain peri-implant health. The aim of this article is to review the currently available evidence related to the design of subgingival (critical and subcritical) and supragingival contours of the implant restorative emergence profile (IREP) as well as provide a flowchart for decision-making in clinical practice...
January 2019: International Journal of Periodontics & Restorative Dentistry
https://read.qxmd.com/read/31788804/quantitative-characterizations-of-the-sharpey-s-fibers-of-rat-molars
#27
JOURNAL ARTICLE
Yongxi Liang, Zhiai Hu, Bei Chang, Xiaohua Liu
BACKGROUND AND OBJECTIVE: The Sharpey's fibers of periodontal ligament (PDL) anchor the PDL to alveolar bone and cementum and are essential for the function of PDL. While qualitative analyses of the Sharpey's fibers have been widely explored, a comprehensive quantitative characterization of the Sharpey's fibers is not available. In this work, we selected rat molars as a model and comprehensively characterized the PDL Sharpey's fibers (diameter, density, length, embedding angle, and insertion angle)...
April 2020: Journal of Periodontal Research
https://read.qxmd.com/read/31506855/three-dimensional-ultrastructural-imaging-and-quantitative-analysis-of-the-periodontal-ligament
#28
REVIEW
Shingo Hirashima, Tomonoshin Kanazawa, Keisuke Ohta, Kei-Ichiro Nakamura
The periodontal ligament (PDL) is a unique connective tissue mainly comprising collagen fiber bundles and cells between the roots of teeth and inner walls of the alveolar-bone socket. PDL fiber bundles are arrayed between teeth and bone, with both ends embedded in the cementum or alveolar bone as Sharpey's fiber. These bundles, synthesized by PDL fibroblasts (PDLFs), form several distinct groups within the PDL which has important functions besides tooth anchoring including tooth nutrition, proprioception, sensory detection, homoeostasis, and repair of damaged tissue...
September 10, 2019: Anatomical Science International
https://read.qxmd.com/read/31491973/biomaterial-based-approaches-for-regeneration-of-periodontal-ligament-and-cementum-using-3d-platforms
#29
REVIEW
Chan Ho Park
Currently, various tissue engineering strategies have been developed for multiple tissue regeneration and integrative structure formations as well as single tissue formation in musculoskeletal complexes. In particular, the regeneration of periodontal tissues or tooth-supportive structures is still challenging to spatiotemporally compartmentalize PCL (poly-ε-caprolactone)-cementum constructs with micron-scaled interfaces, integrative tissue (or cementum) formations with optimal dimensions along the tooth-root surfaces, and specific orientations of engineered periodontal ligaments (PDLs)...
September 5, 2019: International Journal of Molecular Sciences
https://read.qxmd.com/read/31419910/titanium-surface-modifications-and-their-soft-tissue-interface-on-nonkeratinized-soft-tissues-a-systematic-review-review
#30
JOURNAL ARTICLE
Brandaan G R Zigterman, Casper Van den Borre, Annabel Braem, Maurice Y Mommaerts
In this systematic review, the authors explored the surface aspects of various titanium (Ti) or Ti alloy medical implants, examining the interface formed between the implant and surrounding nonkeratinized soft tissues (periosteum, muscles, tendons, fat, cicatrix, or dura mater). A comprehensive search undertaken in July 2019 used strict keywords in relevant electronic databases to identify relevant studies. Based on the authors' inclusion criteria (restricted to in vivo studies), 19 of 651 publications qualified, all pertaining to animal models...
August 16, 2019: Biointerphases
https://read.qxmd.com/read/31306585/stem-cell-conditioned-medium-promotes-graft-remodeling-of-midsubstance-and-intratunnel-incorporation-after-anterior-cruciate-ligament-reconstruction-in-a-rat-model
#31
JOURNAL ARTICLE
Yaying Sun, Wenbo Chen, Yuefeng Hao, Xueping Gu, Xingwang Liu, Jiangyu Cai, Shaohua Liu, Jiwu Chen, Shiyi Chen
BACKGROUND: Stem cell-conditioned medium (CM) has been increasingly used in regenerative medicine. However, its effect on graft-host integration after anterior cruciate ligament (ACL) reconstruction (ACLR) remains unclear. PURPOSE: To examine the effect of human bone marrow stem cell (hBMSC)-CM on graft-bone integration and graft midsubstance ligamentization in a rat model of ACLR. STUDY DESIGN: Controlled laboratory study. METHODS: CM was obtained from the supernatant of commercially available hBMSCs in serum-free Dulbecco's modified Eagle medium (DMEM)...
July 15, 2019: American Journal of Sports Medicine
https://read.qxmd.com/read/31220091/normal-aging-in-human-lumbar-discs-an-ultrastructural-comparison
#32
JOURNAL ARTICLE
Ricardo B V Fontes, Josemberg S Baptista, Said R Rabbani, Vincent C Traynelis, Edson A Liberti
The normal aging of the extracellular matrix and collagen content of the human lumbar intervertebral disc (IVD) remains relatively unknown despite vast amounts of basic science research, partly because of the use of inadequate surrogates for a truly normal, human IVD. Our objective in this study was to describe and compare the morphology and ultrastructure of lumbar IVDs in 2 groups of young (G1-<35 years) and elderly (G2->65 years). Thirty L4-5 and L5-S1 discs per group were obtained during autopsies of presumably-asymptomatic individuals and analyzed with magnetic resonance imaging (MRI), a morphological grading scale, light microscopy, scanning electron microscopy (SEM) and immunohistochemistry (IHC) for collagen types I, II, III, IV, V, VI, IX and X...
2019: PloS One
https://read.qxmd.com/read/30901084/osteohistological-correlates-of-muscular-attachment-in-terrestrial-and-freshwater-testudines
#33
JOURNAL ARTICLE
María Eugenia Pereyra, Paula Bona, Ignacio Alejandro Cerda, Bárbara Desántolo
Sharpey's fibers are considered the anatomical structures integrated to the muscles. Since these fibers leave marks at the microscopic level, their presence and distribution are used as evidence of muscle attachment in extinct and extant forms. In recent years, studies have been focusing on muscle-bone and tendon-bone interaction mostly on mammals. The main objective of this work is to contribute to the morphological and histological knowledge of muscle attachment in other amniotes, such as reptiles, and their variation related to different locomotor habits...
March 22, 2019: Journal of Anatomy
https://read.qxmd.com/read/30849471/an-unusual-disordered-alveolar-bone-material-in-the-upper-furcation-region-of-minipig-mandibles-a-3d-hierarchical-structural-study
#34
JOURNAL ARTICLE
Raquel Maria, Yehonatan Ben-Zvi, Katya Rechav, Eugenia Klein, Ron Shahar, Steve Weiner
Teeth are subjected to compressive loads during mastication. Under small loads the soft tissue periodontal ligament (PDL) deforms most. However when the loads increase and the PDL is highly compressed, the tooth and the alveolar bone supporting the tooth, begin to deform. Here we report on the structure of this alveolar bone in the upper furcation region of the first molars of mature minipigs. Using light microscopy and scanning electron microscopy (SEM) of bone cross-sections, we show that this bone is hypermineralized, containing abundant small pores around 1-5 μm in diameter, lacunae around 10-20 μm as well as larger spaces...
March 5, 2019: Journal of Structural Biology
https://read.qxmd.com/read/30734591/the-effect-of-cpne7-on-periodontal-regeneration
#35
JOURNAL ARTICLE
Han-Wool Choung, Dong-Seol Lee, Yeoung-Hyun Park, Yoon Seon Lee, Shengfeng Bai, Su-Hyang Yoo, Jong-Ho Lee, Hyung-Keun You, Joo-Cheol Park
INTRODUCTION: Preameloblast-conditioned medium (PA-CM), as a mixture of dental epithelium-derived factors has been reported to regenerate dentin and periodontal tissues in vitro and in vivo. Recently, protein copine7 (Cpne7) which was found in PA-CM was suggested to have a beneficial role in periodontal tissue healing. The aim of this study was to investigate the biological effect of Cpne7 on the proliferation, migration, and cementoblast differentiation of periodontal cells in vitro, and on the regeneration of periodontal tissue using periodontal defect model with canine in vivo...
February 8, 2019: Connective Tissue Research
https://read.qxmd.com/read/30653344/osteointegration-of-a-novel-silk-fiber-based-acl-scaffold-by-formation-of-a-ligament-bone-interface
#36
JOURNAL ARTICLE
Andreas Herbert Teuschl, Stefan Tangl, Patrick Heimel, Uwe Yacine Schwarze, Xavier Monforte, Heinz Redl, Thomas Nau
BACKGROUND: Given the unsatisfactory results and reported drawbacks of anterior cruciate ligament (ACL) reconstruction, such as donor site morbidity and the limited choice of grafts in revision surgery, new regenerative approaches based on tissue-engineering strategies are currently under investigation. PURPOSES: To determine (1) if a novel silk fiber-based ACL scaffold is able to initiate osteointegration in the femoral and tibial bone tunnels under in vivo conditions and (2) if the osteointegration process will be improved by intraoperatively seeding the scaffolds with the autologous stromal vascular fraction, an adipose-derived, stem cell-rich isolate from knee fat pads...
January 17, 2019: American Journal of Sports Medicine
https://read.qxmd.com/read/30488444/ddit3-regulates-cementoblast-mineralization-by-isocitrate-dehydrogenase-1-through-nuclear-factor-%C3%AE%C2%BAb-pathway
#37
JOURNAL ARTICLE
Xiayi Liu, Hualing Sun, Miao Yu, Jie Liu, Beining Yang, Yanru Wu, Jiawei Wang
DDIT3 is of great importance in endoplasmic reticulum stress and is involved in many inflammatory diseases and mineralization processes. The cementum protects teeth from periodontitis and provides attachment for Sharpey's fibers of the periodontal ligament. However, the effect of DDIT3 on cementoblast differentiation remains largely unknown. In this study, we found that DDIT3 was suppressed during cementoblast differentiation. Knockdown of DDIT3 increased the messenger RNA (mRNA) and protein levels of several key osteogenic markers in vitro, including alkaline phosphatase, runt-related transcription factor 2, and osteocalcin (OCN)...
November 29, 2018: Journal of Cellular Physiology
https://read.qxmd.com/read/30482233/enhanced-tendon-bone-healing-with-acidic-fibroblast-growth-factor-delivered-in-collagen-in-a-rabbit-anterior-cruciate-ligament-reconstruction-model
#38
JOURNAL ARTICLE
Daifeng Lu, Chuandong Yang, Zhitao Zhang, Mochao Xiao
BACKGROUND: The objective of the present study was to investigate the effectiveness of acidic fibroblast growth factor delivered in collagen (aFGF/collagen) for promoting tendon-bone interface healing after anterior cruciate ligament (ACL) reconstruction in rabbits. METHODS: ACL reconstructions were performed in the right hind limbs of New Zealand rabbits. Each left long digital extensor tendon was harvested as an autograft, and collagen incorporating different concentrations of aFGF or same amount of collagen alone was applied at the tendon-bone interface after ACL reconstruction...
November 27, 2018: Journal of Orthopaedic Surgery and Research
https://read.qxmd.com/read/30285459/advantages-of-an-attached-semitendinosus-tendon-graft-in-anterior-cruciate-ligament-reconstruction-in-a-rabbit-model
#39
JOURNAL ARTICLE
Shaohua Liu, Yaying Sun, Fang Wan, Zheci Ding, Shiyi Chen, Jiwu Chen
BACKGROUND: The semitendinosus tendon graft with an intact tibial insertion has a sustainable blood supply and might be beneficial for graft maturation after anterior cruciate ligament reconstruction (ACLR); however, its potential advantages for graft tendon-bone healing is still unclear. HYPOTHESIS: Intact tibial insertion of the hamstring tendon can preserve enough blood supply to keep the harvested tendon alive, which can improve tendon-bone healing and the biomechanical strength of the graft...
November 2018: American Journal of Sports Medicine
https://read.qxmd.com/read/30101201/periodontal-reconstruction-by-heparan-sulfate-mimetic-based-matrix-therapy-in-porphyromonas-gingivalis-infected-mice
#40
JOURNAL ARTICLE
Benjamin R Coyac, Laurent Detzen, Philippe Doucet, Brigitte Baroukh, Annie Llorens, Martine Bonnaure-Mallet, Marjolaine Gosset, Denis Barritault, Marie-Laure Colombier, Jean-Louis Saffar
Background: Periodontitis is a set of chronic inflammatory diseases affecting the supporting structures of the teeth, during which a persistent release of lytic enzymes and inflammatory mediators causes a self-perpetuating vicious cycle of tissue destruction and repair. A matrix-based therapy using a heparan sulfate (HS) analogue called ReGeneraTing Agent (RGTA) replaces destroyed HS by binding to available heparin-binding sites of structural molecules, leading to restoration of tissue homeostasis in several inflammatory tissue injuries, including a hamster periodontitis model...
August 2018: Heliyon
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