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Sarcopenic obesity

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https://www.readbyqxmd.com/read/27920508/impact-of-whole-body-electromyostimulation-on-cardiometabolic-risk-factors-in-older-women-with-sarcopenic-obesity-the-randomized-controlled-formosa-sarcopenic-obesity-study
#1
Katharina Wittmann, Cornel Sieber, Simon von Stengel, Matthias Kohl, Ellen Freiberger, Franz Jakob, Michael Lell, Klaus Engelke, Wolfgang Kemmler
BACKGROUND: Sarcopenic obesity (SO) is characterized by a combination of low muscle and high fat mass with an additive negative effect of both conditions on cardiometabolic risk. The aim of the study was to determine the effect of whole-body electromyostimulation (WB-EMS) on the metabolic syndrome (MetS) in community-dwelling women aged ≥70 years with SO. METHODS: The study was conducted in an ambulatory university setting. Seventy-five community-dwelling women aged ≥70 years with SO living in Northern Bavaria, Germany, were randomly allocated to either 6 months of WB-EMS application with (WB-EMS&P) or without (WB-EMS) dietary supplementation (150 kcal/day, 56% protein) or a non-training control group (CG)...
2016: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/27903148/obesity-and-energy-balance-in-gi-cancer
#2
Justin C Brown, Jeffrey A Meyerhardt
The prevalence of overweight (body mass index [BMI], 25 to 29.9 kg/m(2)) and obesity (BMI ≥ 30 kg/m(2)) have increased dramatically in the United States. Because increasing BMI is associated with the development of multiple different cancer types, including most GI cancers, providers will frequently encounter patients with GI cancer who are overweight or obese. Mounting evidence associates overweight and/or obesity with worsened prognosis in multiple GI cancers, including esophageal, gastric, hepatocellular, pancreatic, and colorectal...
December 10, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/27890486/towards-a-multidisciplinary-approach-to-understand-and-manage-obesity-and-related-diseases
#3
REVIEW
Stephan C Bischoff, Yves Boirie, Tommy Cederholm, Michael Chourdakis, Cristina Cuerda, Nathalie M Delzenne, Nicolaas E Deutz, Denis Fouque, Laurence Genton, Carmen Gil, Berthold Koletzko, Miguel Leon-Sanz, Raanan Shamir, Joelle Singer, Pierre Singer, Nanette Stroebele-Benschop, Anders Thorell, Arved Weimann, Rocco Barazzoni
Overnutrition and sedentary lifestyle result in overweight or obesity defined as abnormal or excessive fat accumulation that may impair health. According to the WHO, the worldwide prevalence of obesity nearly doubled between 1980 and 2008. In 2008, over 50% of both men and women in the WHO European Region were overweight, and approximately 23% of women and 20% of men were obese. Comprehensive diagnostic and therapeutic approaches should include nutritional treatment to favor the best metabolic and nutritional outcome, as well as to induce potential disease-specific benefits from selected nutritional regimens...
November 16, 2016: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/27885226/association-between-the-nutritional-status-and-the-severity-of-sarcopenia-among-community-dwelling-elderly-japanese-people
#4
Satsuki Komai, Yutaka Watanabe, Yoshinori Fujiwara, Hunkyung Kim, Ayako Edahiro, Hisashi Kawai, Hideyo Yoshida, Shuichi Obuchi, Yayoi Tanaka, Hirohiko Hirano
AIM: To investigate the association between nutritional evaluation indices (body mass index, albumin, and weight loss) and sarcopenia severity among community-dwelling elderly people in Japan. METHODS: The subjects consisted of 758 community-dwelling elderly people ≥65 years of age, categorized into two groups by based on Operation of long life medical care system (medical care system for elderly in the latter stage of life), the cut-off value for age used was 75...
2016: Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics
https://www.readbyqxmd.com/read/27883321/body-size-and-outcomes-in-dialysis-and-transplant-patients-does-it-matter
#5
Mehmet Sukru Sever
The terminologies of "body size", "body mass index (BMI)", "body weight", "large BMI" and "obesity" are controversial for defining the effects of "adiposity" or "fat excess" on the outcomes of dialysis and transplant patients. However, probably these terminologies will be continued to be used in the future as well, because of being older and simpler terminologies. In the general population obesity is a powerful risk factor for cardiovascular morbidity and mortality, while, it conferred a survival advantage to dialysis patients...
November 1, 2016: Prilozi (Makedonska Akademija Na Naukite i Umetnostite. Oddelenie za Medicinski Nauki)
https://www.readbyqxmd.com/read/27876469/sarcopenic-obesity-definitions-by-body-composition-and-mortality-in-the-hemodialysis-patients
#6
Rakesh Malhotra, Serpil M Deger, Huzaifah Salat, Aihua Bian, Thomas G Stewart, Cindy Booker, Andrew Vincz, Brianna Pouliot, T Alp Ikizler
OBJECTIVE: Sarcopenic obesity (SO), a combination of low muscle mass and high fat mass, is considered as risk factor for mortality in general population. It is unclear if SO affects mortality in maintenance hemodialysis (MHD) patients. In this study, we aimed to determine whether body composition as assessed by currently available SO definitions is related to all-cause mortality in MHD subjects. We also examined the impact of applying different definitions on the prevalence of SO in our MHD database...
November 19, 2016: Journal of Renal Nutrition
https://www.readbyqxmd.com/read/27864687/omega-3-fatty-acid-epa-improves-regenerative-capacity-of-mouse-skeletal-muscle-cells-exposed-to-saturated-fat-and-inflammation
#7
Amarjit Saini, Adam P Sharples, Nasser Al-Shanti, Claire E Stewart
Sarcopenic obesity is characterised by high fat mass, low muscle mass and an elevated inflammatory environmental milieu. We therefore investigated the effects of elevated inflammatory cytokine TNF-α (aging/obesity) and saturated fatty acid, palmitate (obesity) on skeletal muscle cells in the presence/absence of EPA, a-3 polyunsaturated fatty acid with proposed anti-inflammatory, anti-obesity activities. In the present study we show that palmitate was lipotoxic, inducing high levels of cell death and blocking myotube formation...
November 18, 2016: Biogerontology
https://www.readbyqxmd.com/read/27855417/testosterone-deficiency-and-testosterone-treatment-in-older-men
#8
Farid Saad, Gabriele Röhrig, Stephan von Haehling, Abdulmaged Traish
Frailty is a clinical condition related to changes in metabolism, to sarcopenia, and to decline in muscle mass and strength, bone mineral density, and physical function with aging. The pathophysiology of frailty is multifactorial and associated with comorbidities. Testosterone is implicated in regulating metabolic functions, maintenance of muscle and bone, and inhibition of adipogenesis. In older individuals, reduced testosterone is thought to contribute to an altered state of metabolism, loss of muscle and bone, and increased fat, leading to sarcopenia, sarcopenic obesity, and frailty...
November 18, 2016: Gerontology
https://www.readbyqxmd.com/read/27824658/influences-of-resistance-training-on-physical-function-in-older-obese-men-and-women-with-sarcopenia
#9
Katja Stoever, Anke Heber, Sabine Eichberg, Klara Brixius
BACKGROUND AND PURPOSE: Sarcopenic obesity is associated with disability, gait problems, and falls. Activities of daily living such as walking and climbing stairs are physically difficult or impossible for the individual with severe obesity. These aspects also limit participation in recreational activities or exercise programs. However, good muscle function is crucial to maintain functional independence. The objective of this study was to investigate the influence of resistance training on physical function in older, obese persons with sarcopenia...
November 7, 2016: Journal of Geriatric Physical Therapy
https://www.readbyqxmd.com/read/27810702/low-muscle-attenuation-is-a-prognostic-factor-for-survival-in-metastatic-breast-cancer-patients-treated-with-first-line-palliative-chemotherapy
#10
Hánah N Rier, Agnes Jager, Stefan Sleijfer, Joost van Rosmalen, Marc C J M Kock, Mark-David Levin
BACKGROUND: Low muscle mass (LMM) and low muscle attenuation (LMA) reflect low muscle quantity and low muscle quality, respectively. Both are associated with a poor outcome in several types of solid malignancies. This study determined the association of skeletal muscle measures with overall survival (OS) and time to next treatment (TNT). PATIENTS AND METHODS: A skeletal muscle index (SMI) in cm(2)/m(2) and muscle attenuation (MA) in Hounsfield units (HU) were measured using abdominal CT-images of 166 patients before start of first-line chemotherapy for metastatic breast cancer...
October 27, 2016: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/27809450/sarcopenia-and-sarcopenic-obesity
#11
REVIEW
Kyung Mook Choi
Sarcopenia is an age-associated loss of muscle mass and decline in muscle strength; it is common in older adults and is associated with significant morbidity and mortality. Despite its prevalence, there is currently no universally adopted definition of sarcopenia. In addition to low muscle mass measurements, recent research has recognized the importance of muscle strength and physical performance. Aging induces changes in body composition, such as an increase in visceral fat and reduced muscle mass. Recently, the new concept of sarcopenic obesity has emerged, reflecting a combination of sarcopenia and obesity...
November 2016: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/27801546/defying-geometric-similarity-shape-centralization-in-male-uk-offshore-workers
#12
Arthur D Stewart, Robert J Ledingham, Graham Furnace, Hector Williams, Alan M Nevill
OBJECTIVES: Applying geometric similarity predictions of body dimensions to specific occupational groups has the potential to reveal useful ergonomic and health implications. This study assessed a representative sample of the male UK offshore workforce, and examined how body dimensions from sites typifying musculoskeletal development or fat accumulation, differed from predicted values. METHODS: A cross sectional sample was obtained across seven weight categories using quota sampling, to match the wider workforce...
November 1, 2016: American Journal of Human Biology: the Official Journal of the Human Biology Council
https://www.readbyqxmd.com/read/27800156/sarcopenia-and-sarcopenic-obesity-do-they-predict-inferior-oncologic-outcomes-after-gastrointestinal-cancer-surgery
#13
REVIEW
Kimberly L Mei, John A Batsis, Jeannine B Mills, Stefan D Holubar
Sarcopenia, or loss of skeletal muscle mass and quality, has been studied as part of aging and adverse health outcomes in elderly patients but has only recently been evaluated as a separate condition in cancer patients and important indicator of adverse outcomes. Currently, its definition and method of assessment are still being debated. Sarcopenia within an increasingly obese population has led to a subgroup with sarcopenic obesity, at even higher risk of adverse outcomes. Yet, sarcopenia often goes undiagnosed in these patients, hidden beneath higher body mass index...
2016: Perioperative Medicine
https://www.readbyqxmd.com/read/27791227/sarcopenic-obesity-and-metabolic-syndrome-in-adult-caucasian-subjects
#14
E Poggiogalle, C Lubrano, G Sergi, A Coin, L Gnessi, S Mariani, A Lenzi, L M Donini
OBJECTIVES: Recently metabolic aspects linked to sarcopenic obesity (SO) were investigated. Extant studies involved especially older people from Asian or White-mixed American cohorts. THE AIMS OF OUR STUDY WERE: to explore the prevalence of sarcopenia in Caucasian adult obese subjects using two different indices of sarcopenia, and to investigate the relationship among SO, metabolic syndrome (MS), inflammation, and serum albumin concentrations. DESIGN: Cross- sectional study...
2016: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/27776918/chronic-kidney-disease-and-high-egfr-according-to-body-composition-phenotype-in-adults-with-normal-bmi
#15
Y Y Hyun, K B Lee, E J Rhee, C Y Park, Y Chang, S Ryu
BACKGROUND AND AIMS: Body composition contributes to the risk of chronic kidney disease (CKD) and glomerular hyperfiltration. In adults with normal body mass index (BMI), the relationships of body composition with CKD and high estimated glomerular filtration rate (eGFR) are largely unknown. METHODS AND RESULTS: We analyzed 10,734 adults from the Korean National Health and Nutrition Examination Survey (KNHANES), whose body mass index (BMI) was within the normal range (18...
December 2016: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/27759996/association-between-sarcopenic-obesity-and-cardiovascular-risk-where-are-we
#16
Maria Helena Gusmao-Sena, Karine Curvello-Silva, Jairza Maria Barreto-Medeiros, Carla Hilário Da-Cunha-Daltro
INTRODUCTION: The main changes in the body composition refer to the increase of adipose tissue and/or the decrease of muscular mass, and these changes have effect in many clinical outcomes. Sarcopenic obesity (SO) consists of the presence of excessive adipose tissue and deficit of muscular mass simultaneously. People with SO may have synergistic effect due to obesity and sarcopenia, with increases cardiovascular risk more than obesity itself. OBJECTIVE: To describe the findings in the literature about the association between SO and risk factors and/or cardiometabolic disease (CMD) or cardiovascular disease (CVD)...
September 20, 2016: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/27737790/vector-bioimpedance-detects-situations-of-malnutrition-not-identified-by-the-indicators-commonly-used-in-geriatric-nutritional-assessment-a-pilot-study
#17
Ma Paz Redondo-Del-Río, Ma Alicia Camina-Martín, Laura Moya-Gago, Sandra de-la-Cruz-Marcos, Vincenzo Malafarina, Beatriz de-Mateo-Silleras
OBJECTIVE: To compare body composition as assessed by conventional and vector bioelectrical impedance analysis according to the nutritional cataloging using body mass index (BMI) in a group of institutionalized elderly. METHODS: Cross-sectional study in 38 institutionalized elderly. Body composition was estimated by bioimpedance analysis. Differences in body composition were analyzed using t-test and ANOVA, or their corresponding nonparametric tests. Statistical significance was set at p<0...
October 10, 2016: Experimental Gerontology
https://www.readbyqxmd.com/read/27736026/sarcopenic-obesity-and-its-temporal-associations-with-changes-in-bone-mineral-density-incident-falls-and-fractures-in-older-men-the-concord-health-and-ageing-in-men-project
#18
David Scott, Markus Seibel, Robert Cumming, Vasi Naganathan, Fiona Blyth, David G Le Couteur, David J Handelsman, Louise M Waite, Vasant Hirani
Body composition and muscle function have important implications for falls and fractures in older adults. We aimed to investigate longitudinal associations between sarcopenic obesity and its components with bone mineral density (BMD), and incident falls and fractures, in Australian community-dwelling older men. 1,486 men aged ≥70 years from the Concord Health and Ageing in Men Project (CHAMP) study were assessed at baseline (2005-2007), 2 year follow-up (2007-2009; N = 1,238), and 5 year follow-up (2010-2013; N = 861)...
October 13, 2016: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/27717662/the-most-effective-factors-to-offset-sarcopenia-and-obesity-in-the-older-korean-physical-activity-vitamin-d-and-protein-intake
#19
Chorong Oh, Byeong Hwan Jeon, Shaun Nicholas Reid Storm, Sunkug Jho, Jae-Kyung No
OBJECTIVE: The aim of this study was to evaluate the effects of the types and levels of physical activity in conjunction with protein intake and vitamin D on sarcopenia and obesity status in an elderly population. METHODS: Study participants (N = 4452) were ages ≥60 y and included 1929 men and 2523 women who completed a body composition analysis with a dual energy x-ray absorptiometry and provided health and dietary data. RESULTS: Higher appendicular skeletal muscle mass/weight was observed in the non-obese group, although obese participants had greater weights...
January 2017: Nutrition
https://www.readbyqxmd.com/read/27702700/sarcopenic-obesity-or-obese-sarcopenia-a-cross-talk-between-age-associated-adipose-tissue-and-skeletal-muscle-inflammation-as-a-main-mechanism-of-the-pathogenesis
#20
REVIEW
Alexander Kalinkovich, Gregory Livshits
Sarcopenia, an age-associated decline in skeletal muscle mass coupled with functional deterioration, may be exacerbated by obesity leading to higher disability, frailty, morbidity and mortality rates. In the combination of sarcopenia and obesity, the state called sarcopenic obesity (SOB), some key age- and obesity-mediated factors and pathways may aggravate sarcopenia. This review will analyze the mechanisms underlying the pathogenesis of SOB. In obese adipose tissue (AT), adipocytes undergo hypertrophy, hyperplasia and activation resulted in accumulation of pro-inflammatory macrophages and other immune cells as well as dysregulated production of various adipokines that together with senescent cells and the immune cell-released cytokines and chemokines create a local pro-inflammatory status...
October 1, 2016: Ageing Research Reviews
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