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Sarcopenic obesity

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https://www.readbyqxmd.com/read/29678696/sarcopenic-obesity-revisited-insights-from-the-mr-and-ms-os-cohort
#1
Jean Woo, Jason Leung
OBJECTIVES: Following the concept of a metabolic load-capacity model, we propose the use of appendicular skeletal muscle mass (ASM) to total body fat (TBF) ratio in predicting 4-year physical limitations, physical performance measures, 6-year incident diabetes and cardiovascular diseases, and 12-year mortality. DESIGN: Cross-sectional and prospective cohort study. SETTING AND PARTICIPANTS: 4000 men and women aged 65 years and older living in the community...
April 17, 2018: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/29677586/impact-of-sarcopenic-obesity-on-30-day-mortality-in-critically-ill-patients-with-intra-abdominal-sepsis
#2
Yun Ji, Baoli Cheng, Zhipeng Xu, Hui Ye, Weina Lu, Xiaoqian Luo, Shuiqiao Fu, Xiangming Fang
PURPOSE: This study aimed to investigate the association between sarcopenic obesity and 30-day mortality in critically ill patients with intra-abdominal sepsis. MATERIAL AND METHODS: We analyzed 236 surgical ICU patients with sepsis due to intra-abdominal infection who underwent urgent surgical intervention. Sarcopenia, visceral obesity and sarcopenic obesity were analyzed by computed tomography scans using the third lumbar vertebrae skeletal muscle index and visceral adipose tissue area, using previously reported cutoff values...
March 16, 2018: Journal of Critical Care
https://www.readbyqxmd.com/read/29675640/effects-of-combined-whole-body-electromyostimulation-and-protein-supplementation-on-local-and-overall-muscle-fat-distribution-in-older-men-with-sarcopenic-obesity-the-randomized-controlled-franconia-sarcopenic-obesity-franso-study
#3
Wolfgang Kemmler, Alexandra Grimm, Michael Bebenek, Matthias Kohl, Simon von Stengel
The primary aim of the project was to determine the combined effect of whole-body electromyostimulation (WB-EMS) and protein supplements on local and overall muscle/fat distribution in older man with sarcopenic obesity (SO). Community-dwelling (cdw) men ≥ 70 years with SO were randomly allocated to a WB-EMS and protein supplementation (n = 33) or a non-intervention control group (CG: n = 34). WB-EMS was conducted 1.5 sessions of 20 min/week for 16 weeks. Whey protein supplementation aimed to ensure a daily intake of 1...
April 19, 2018: Calcified Tissue International
https://www.readbyqxmd.com/read/29665258/health-related-quality-of-life-and-fall-risk-associated-with-age-related-body-composition-changes-sarcopenia-obesity-and-sarcopenic-obesity
#4
Zeynel Abidin Öztürk, İbrahim Halil Türkbeyler, Azer Abiyev, Seval Kul, Bahadır Edizer, Funda Datli Yakaryılmaz, Gülçimen Soylu
BACKGROUND: Sarcopenia, obesity, and sarcopenic obesity are various features of the aging process that can cause important health issues. The present study was undertaken to investigate the interrelationship between those body composition changes including their clinical components and the quality of life variables. METHODS: 423 individuals aged 65 years or more were included in this cross-sectional study. Sarcopenia was diagnosed according to The European Working Group on Sarcopenia in Older People criteria...
April 17, 2018: Internal Medicine Journal
https://www.readbyqxmd.com/read/29662761/inflammation-and-age-associated-skeletal-muscle-deterioration-sarcopaenia
#5
REVIEW
Jinyu Wang, Kwok-Sui Leung, Simon Kwoon-Ho Chow, Wing-Hoi Cheung
Ageing is accompanied by chronic inflammatory responses due to elevated circulatory inflammatory cytokine production. Several inflammatory cytokines have been shown to be responsible for a decrease in muscle mass. However, little is known about the possible relationship between inflammation and sarcopaenia. This review aims to summarise the existing evidence about inflammation and sarcopaenia. Sarcopaenia is defined as an age-related decrease of muscle mass and/or muscle strength; it is caused by multiple factors, such as skeletal muscle atrophy, neuromuscular junction degeneration, hormone imbalance, cytokine imbalance, protein synthesis and proteolysis...
July 2017: Journal of Orthopaedic Translation
https://www.readbyqxmd.com/read/29649572/associations-of-sarcopenic-obesity-with-the-metabolic-syndrome-and-insulin-resistance-over-five-years-in-older-men-the-concord-health-and-ageing-in-men-project
#6
David Scott, Robert Cumming, Vasi Naganathan, Fiona Blyth, David G Le Couteur, David J Handelsman, Markus Seibel, Louise M Waite, Vasant Hirani
PURPOSE: Previous cross-sectional studies investigating associations of sarcopenic obesity with metabolic syndrome (MetS) and insulin resistance have not utilised consensus definitions of sarcopenia. We aimed to determine associations of sarcopenic obesity with MetS and insulin resistance over five years in community-dwelling older men. METHODS: 1231 men aged ≥70 years had appendicular lean mass (ALM) and body fat percentage assessed by dual-energy X-ray absorptiometry and hand grip strength and gait speed tests...
April 9, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29588579/resistance-training-induced-gains-in-muscle-strength-body-composition-and-functional-capacity-are-attenuated-in-elderly-women-with-sarcopenic-obesity
#7
Alessandro de Oliveira Silva, Maurílio Tiradentes Dutra, Wilson Max Almeida Monteiro de Moraes, Silvana Schwerz Funghetto, Darlan Lopes de Farias, Paulo Henrique Fernandes Dos Santos, Denis Cesar Leite Vieira, Dahan da Cunha Nascimento, Vânia Silva Macedo Orsano, Brad J Schoenfeld, Jonato Prestes
Objectives: The purpose of this study was to compare the effects of resistance training (RT) on body composition, muscle strength, and functional capacity in elderly women with and without sarcopenic obesity (SO). Methods: A total of 49 women (aged ≥60 years) were divided in two groups: without SO (non-SO, n=41) and with SO (n=8). Both groups performed a periodized RT program consisting of two weekly sessions for 16 weeks. All measures were assessed at baseline and postintervention, including anthropometry and body composition (dual-energy X-ray absorptiometry), muscle strength (one repetition maximum) for chest press and 45° leg press, and functional capacity (stand up, elbow flexion, timed "up and go")...
2018: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29568333/relationship-between-a-body-shape-index-absi-and-body-composition-in-obese-patients-with-type-2-diabetes
#8
Fernando Gomez-Peralta, Cristina Abreu, Margarita Cruz-Bravo, Elvira Alcarria, Gala Gutierrez-Buey, Nir Y Krakauer, Jesse C Krakauer
Background: Obesity is known to be related to the development of type 2 diabetes mellitus (T2D). The most commonly used anthropometric indicator (body mass index [BMI]) presents several limitations such as the lack of possibility to distinguish adipose tissue distribution. Thus, this study examines the suitability of a body shape index (ABSI) for prediction of body composition and sarcopenic obesity in obese or overweight T2D subjects. Methods: Cross-sectional study in 199 overweight/obese T2D adults...
2018: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/29564306/sarcopenic-obesity-in-elderly-korean-women-a-nationwide-cross-sectional-study
#9
Young Nam Kwon, Sung Sang Yoon, Kyung-Hag Lee
Background: Sarcopenia causes loss of muscle mass in the elderly and is associated with development of metabolic syndrome in those with obesity. This study evaluated the prevalence of sarcopenic obesity (SO) in healthy Korean elderly women. Methods: This study was based on data from the Korea National Health and Nutrition Examination Survey IV and V, 2008-2011. Whole body dual energy X-ray absorptiometry and body mass index measurement were performed for all patients...
February 2018: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/29563041/exercise-alone-or-combined-with-dietary-supplements-for-sarcopenic-obesity-in-community-dwelling-older-people-a-systematic-review-of-randomized-controlled-trials
#10
REVIEW
Antonio Martínez-Amat, Agustín Aibar-Almazán, Raquel Fábrega-Cuadros, David Cruz-Díaz, José D Jiménez-García, Faustino R Pérez-López, Alexander Achalandabaso, Rafael Barranco-Zafra, Fidel Hita-Contreras
Sarcopenic obesity (SO) represents a major public health concern. Physical activity has been recommended to minimize functional decline in the elderly and it may also be relevant to SO management. The purpose of this systematic review of randomized controlled trials (RCTs) was to investigate the effects of different exercise modalities, alone or combined with nutritional supplementation, on body composition, muscle strength and physical function in healthy community-dwelling older adults with SO. A literature search was performed using the PubMed, SCOPUS, CINAHL and Cochrane Plus databases...
April 2018: Maturitas
https://www.readbyqxmd.com/read/29534532/characterization-of-ageing-and-diet-related-swine-models-of-sarcopenia-and-sarcopenic-obesity
#11
Consolacion Garcia-Contreras, Marta Vazquez-Gomez, Laura Torres-Rovira, Jorge Gonzalez, Esteban Porrini, Magali Gonzalez-Colaço, Beatriz Isabel, Susana Astiz, Antonio Gonzalez-Bulnes
Sarcopenia and sarcopenic obesity are currently considered major global threats for health and well-being. However, there is a lack of adequate preclinical models for their study. The present trial evaluated the suitability of aged swine by determining changes in adiposity, fatty acids composition, antioxidant status and lipid peroxidation, development of metabolic disturbances and structural changes in tissues and organs. Iberian sows with clinical evidence of aging-related sarcopenia were fed a standard diet fulfilling their maintenance requirements or an obesogenic diet for 100 days...
March 12, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29529140/comment-on-sarcopenic-obesity-weight-loss-and-mortality-the-english-longitudinal-study-of-aging
#12
Ru Wang, Peijie Chen
No abstract text is available yet for this article.
February 1, 2018: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29523089/effect-of-whole-body-electromyostimulation-and-or-protein-supplementation-on-obesity-and-cardiometabolic-risk-in-older-men-with-sarcopenic-obesity-the-randomized-controlled-franso-trial
#13
Wolfgang Kemmler, Matthias Kohl, Ellen Freiberger, Cornel Sieber, Simon von Stengel
BACKGROUND: Sarcopenic Obesity (SO) is characterized by low lean and high fat mass; i.e. from a functional aspect a disproportion between engine (muscle) and mass to be moved (fat). At present, most research focuses on the engine, but the close "cross talk" between age-associated adipose and skeletal muscle tissue inflammation calls for comprehensive interventions that affect both components alike. Protein and exercise are likely candidates, however with respect to the latter, the enthusiasm for intense and frequent exercise is rather low, especially in functionally limited older people...
March 9, 2018: BMC Geriatrics
https://www.readbyqxmd.com/read/29506228/sarcopenic-obesity-hidden-muscle-wasting-and-its-impact-for-survival-and-complications-of-cancer-therapy
#14
V E Baracos, L Arribas
Body composition, defined as the proportions and distribution of lean and fat tissues in the human body, is an emergent theme in clinical oncology. Severe muscle depletion (sarcopenia) is most easily overlooked in obese patients; the advent of secondary analysis of oncologic images provides a precise and specific assessment of sarcopenia. Here, we review the definitions, prevalence and clinical implications of sarcopenic obesity (SO) in medical and surgical oncology. Reported prevalence of SO varies due to the heterogeneity in the definitions and the variability in the cut points used to define low muscle mass and high fat mass...
February 1, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29500672/preoperative-detection-of-sarcopenic-obesity-helps-to-predict-the-occurrence-of-gastric-leak-after-sleeve-gastrectomy
#15
Martin Gaillard, Hadrien Tranchart, Sophie Maitre, Gabriel Perlemuter, Panagiotis Lainas, Ibrahim Dagher
BACKGROUND: Sleeve gastrectomy (SG) has become the primary procedure for many bariatric teams and staple-line leak represents its most feared complication. Sarcopenic obesity combines the risks of obesity and depleted lean mass leading possibly to an inferior surgical outcome after abdominal surgery. OBJECTIVES: The aim of this study was to evaluate the existence of a potential link between radiologically determined sarcopenic obesity and staple-line leak risk after SG...
March 2, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29499977/sarcopenic-obesity-and-overall-mortality-results-from-the-application-of-novel-models-of-body-composition-phenotypes-to-the-national-health-and-nutrition-examination-survey-1999-2004
#16
Carla Van Aller, Jose Lara, Blossom C M Stephan, Lorenzo Maria Donini, Steven Heymsfield, Peter T Katzmarzyk, Jonathan C K Wells, Carla M Prado, Mario Siervo
BACKGROUND/OBJECTIVES: There is no consensus on the definition of sarcopenic obesity (SO), resulting in inconsistent associations of SO with mortality risk. We aim to evaluate association of dual energy x-ray absorptiometry (DXA) SO models with mortality risk in a US adult population (≥50 years). SUBJECTS/METHODS: The study population consisted of 3577 participants aged 50 years and older from the 1999-2004 National Health and Nutrition and Examination Survey with mortality follow-up data through December 31, 2011...
February 15, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29460818/sarcopenic-obesity-and-health-outcomes-in-patients-seeking-weight-loss-treatment
#17
Jingjie Xiao, Angelina Cain, Sarah A Purcell, Michael J Ormsbee, Robert J Contreras, Jeong-Su Kim, Robert Thornberry, Dawn Springs, M Cristina Gonzalez, Carla M Prado
AIM: To investigate the prevalence of sarcopenic obesity (SO) and its association with health outcomes in patients seeking weight loss treatment from a bariatric center. METHODS: In this retrospective study, patients [≥18 years old, body mass index (BMI) ≥30 kg/m2 ] from the Tallahassee Memorial Bariatric Center and with baseline body composition assessment by bioelectrical impedance analysis were included. Fat mass index (FMI = fat mass/height2 ) and fat-free mass index (FFMI = fat free mass/height2 ) were calculated...
February 2018: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/29452783/oxidative-stress-is-increased-in-sarcopenia-and-associated-with-cardiovascular-disease-risk-in-sarcopenic-obesity
#18
Francesco Bellanti, Antonino D Romano, Aurelio Lo Buglio, Valeria Castriotta, Giuseppe Guglielmi, Antonio Greco, Gaetano Serviddio, Gianluigi Vendemiale
OBJECTIVES: To define whether circulating markers of oxidative stress correlate with sarcopenia in terms of glutathione balance and oxidative protein damage, and whether these biomarkers are associated with risk of cardiovascular disease (CVD). STUDY DESIGN: Population-based cross-sectional study. 115 out of 347 elderly subjects were classified as non-sarcopenic non-obese (NS-NO), sarcopenic non-obese (S-NO), non-sarcopenic obese (NS-O), and sarcopenic obese (S-O)...
March 2018: Maturitas
https://www.readbyqxmd.com/read/29417293/enhancing-evaluation-of-sarcopenia-in-patients-with-non-small-cell-lung-cancer-nsclc-by-assessing-skeletal-muscle-index-smi-at-the-first-lumbar-l1-level-on-routine-chest-computed-tomography-ct
#19
Alejandro Recio-Boiles, Jose N Galeas, Bernard Goldwasser, Karla Sanchez, Louise M W Man, Ryan D Gentzler, Jane Gildersleeve, Patricia J Hollen, Richard J Gralla
PURPOSE: Ongoing cancer cachexia trials evaluate sarcopenia by skeletal muscle index (SMI) at the L3 vertebrae level, commonly used as a standard. Routine chest CT institutional protocols widely differ in including L3. We investigated whether SMI at L1 assessment, rather than L3, would be reliable and more practicable for non-small cell lung cancer (NSCLC). METHODS: NSCLC patients with routine CT chest had SMI measurements performed at L1 using Slice-O-Matic software...
February 7, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29412438/the-vicious-cycle-of-myostatin-signaling-in-sarcopenic-obesity-myostatin-role-in-skeletal-muscle-growth-insulin-signaling-and-implications-for-clinical-trials
#20
L A Consitt, B C Clark
The age-related loss of skeletal muscle (sarcopenia) is a major health concern as it is associated with physical disability, metabolic impairments, and increased mortality. The coexistence of sarcopenia with obesity, termed 'sarcopenic obesity', contributes to skeletal muscle insulin resistance and the development of type 2 diabetes, a disease prevalent with advancing age. Despite this knowledge, the mechanisms contributing to sarcopenic obesity remain poorly understood, preventing the development of targeted therapeutics...
2018: Journal of Frailty & Aging
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