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https://www.readbyqxmd.com/read/29793160/water-footprint-characteristic-of-less-developed-water-rich-regions-case-of-yunnan-china
#1
Yiying Qian, Huijuan Dong, Yong Geng, Shaozhuo Zhong, Xu Tian, Yanhong Yu, Yihui Chen, Dana Avery Moss
Rapid industrialization and urbanization pose pressure on water resources in China. Virtual water trade proves to be an increasingly useful tool in water stress alleviation for water-scarce regions, while bringing opportunities and challenges for less developed water-rich regions. In this study, Yunnan, a typical province in southwest China, was selected as the case study area to explore its potential in socio-economic development in the context of water sustainability. Both input-output analysis and structural decomposition analysis on Yunnan's water footprint for the period of 2002-2012 were performed at not only an aggregated level but also a sectoral level...
March 30, 2018: Water Research
https://www.readbyqxmd.com/read/29792714/docking-screens-for-dual-inhibitors-of-disparate-drug-targets-for-parkinson-s-disease
#2
Mariama Jaiteh, Alexey Zeifman, Marcus Saarinen, Per Svenningsson, José M Brea, Maria Isabel Loza, Jens Carlsson
Modulation of multiple biological targets with a single drug can lead to synergistic therapeutic effects and has been demonstrated to be essential for efficient treatment of CNS disorders. However, rational design of compounds that interact with several targets is very challenging. Here, we demonstrate that structure-based virtual screening can guide the discovery of multi-target ligands of unrelated proteins relevant for Parkinson's disease. A library with 5.4 million molecules was docked to crystal structures of the A2A adenosine receptor (A2AAR) and monoamine oxidase B (MAO-B)...
May 24, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29792509/modulation-of-excitability-in-the-temporoparietal-junction-relieves-virtual-reality-sickness
#3
Naoyuki Takeuchi, Takayuki Mori, Yoshimi Suzukamo, Shin-Ichi Izumi
Virtual reality (VR) immersion often provokes subjective discomfort and postural instability, so called VR sickness. The neural mechanism of VR sickness is speculated to be related to visual-vestibular information mismatch and/or postural instability. However, the approaches proposed to relieve VR sickness through modulation of brain activity are poorly understood. Using transcranial direct current stimulation (tDCS), we aimed to investigate whether VR sickness could be relieved by the modulation of cortical excitability in the temporoparietal junction (TPJ), which is known to be involved in processing of both vestibular and visual information...
May 24, 2018: Cyberpsychology, Behavior and Social Networking
https://www.readbyqxmd.com/read/29792052/randomized-clinical-trial-of-computerized-and-clinician-delivered-cbt-in-comparison-with-standard-outpatient-treatment-for-substance-use-disorders-primary-within-treatment-and-follow-up-outcomes
#4
Brian D Kiluk, Charla Nich, Matthew B Buck, Kathleen A Devore, Tami L Frankforter, Donna M LaPaglia, Srinivas B Muvvala, Kathleen M Carroll
OBJECTIVE: Previous trials have demonstrated the efficacy and durability of computer-based cognitive-behavioral therapy (CBT4CBT) as an add-on to standard outpatient care in a range of treatment-seeking populations. In this study, the authors evaluated the efficacy and safety of CBT4CBT as a virtual stand-alone treatment, delivered with minimal clinical monitoring, and clinician-delivered cognitive-behavioral therapy (CBT) compared with treatment as usual in a heterogeneous sample of treatment-seeking outpatients with substance use disorders...
May 24, 2018: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29791691/evaluation-of-miniscrew-angulation-in-the-posterior-maxilla-using-cone-beam-computed-tomographic-image
#5
Henrique M Villela, Mario Vedovello Filho, Heloísa C Valdrighi, Milton Santamaria-Jr, Carolina Carmo de Menezes, Silvia A S Vedovello
OBJECTIVE: This study aimed at evaluating whether changes in the insertion angle is a determining factor in the positioning of the miniscrews body in a region with larger interradicular space in the posterior maxilla. METHODS: Analysis of 60 posterior maxillary quadrants were made using images obtained by means of cone-beam computed tomographic image (CBCT), with 0.076-mm voxel, which presented a real miniscrew inserted in the mesial region of the maxillary first molars, serving as reference point for the placement of the virtual miniscrews...
January 2018: Dental Press Journal of Orthodontics
https://www.readbyqxmd.com/read/29791645/gerontological-contributions-to-the-care-of-elderly-people-in-long-term-care-facilities
#6
Vanessa da Silva Antonio Coimbra, Rose Mary Costa Rosa Andrade Silva, Fabiana Lopes Joaquim, Eliane Ramos Pereira
OBJECTIVE: To analyze Brazilian scientific productions from the last 11 years which show the contributions of nursing to elderly people in long-term care facilities. METHOD: This is an integrative literature review. The search took place in the Virtual Health Library (VHL) in the BDENF and LILACS databases and the SCIELO virtual library, between June and October 2016, using the keyword long-term care facility and the descriptors nursing and geriatrics. RESULTS: Eleven studies were selected, published 2005 and 2016, with various methodological approaches that enabled discussion of the proposed objective...
2018: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/29791554/chest-x-ray-and-chest-ct-findings-in-patients-diagnosed-with-pulmonary-tuberculosis-following-solid-organ-transplantation-a-systematic-review
#7
Irai Luis Giacomelli, Roberto Schuhmacher Neto, Edson Marchiori, Marisa Pereira, Bruno Hochhegger
The objective of this systematic review was to select articles including chest X-ray or chest CT findings in patients who developed pulmonary tuberculosis following solid organ transplantation (lung, kidney, or liver). The following search terms were used: "tuberculosis"; "transplants"; "transplantation"; "mycobacterium"; and "lung". The databases used in this review were PubMed and the Brazilian Biblioteca Virtual em Saúde (Virtual Health Library). We selected articles in English, Portuguese, or Spanish, regardless of the year of publication, that met the selection criteria in their title, abstract, or body of text...
April 2018: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
https://www.readbyqxmd.com/read/29791513/vaccine-induced-antibodies-to-herpes-simplex-virus-glycoprotein-d-epitopes-involved-in-virus-entry-and-cell-to-cell-spread-correlate-with-protection-against-genital-disease-in-guinea-pigs
#8
Lauren M Hook, Tina M Cairns, Sita Awasthi, Benjamin D Brooks, Noah T Ditto, Roselyn J Eisenberg, Gary H Cohen, Harvey M Friedman
Herpes simplex virus type 2 (HSV-2) glycoprotein D (gD2) subunit antigen is included in many preclinical candidate vaccines. The rationale for including gD2 is to produce antibodies that block crucial gD2 epitopes involved in virus entry and cell-to-cell spread. HSV-2 gD2 was the only antigen in the Herpevac Trial for Women that protected against HSV-1 genital infection but not HSV-2. In that trial, a correlation was detected between gD2 ELISA titers and protection against HSV-1, supporting the importance of antibodies...
May 23, 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29791498/a-systematic-approach-to-parameter-selection-for-cad-virtual-reality-data-translation-using-response-surface-methodology-and-moga-ii
#9
Mustufa Haider Abidi, Abdulrahman Al-Ahmari, Ali Ahmad
Advanced graphics capabilities have enabled the use of virtual reality as an efficient design technique. The integration of virtual reality in the design phase still faces impediment because of issues linked to the integration of CAD and virtual reality software. A set of empirical tests using the selected conversion parameters was found to yield properly represented virtual reality models. The reduced model yields an R-sq (pred) value of 72.71% and an R-sq (adjusted) value of 86.64%, indicating that 86.64% of the response variability can be explained by the model...
2018: PloS One
https://www.readbyqxmd.com/read/29791445/the-search-for-instantaneous-vection-an-oscillating-visual-prime-reduces-vection-onset-latency
#10
Stephen Palmisano, Bernhard E Riecke
Typically it takes up to 10 seconds or more to induce a visual illusion of self-motion ("vection"). However, for this vection to be most useful in virtual reality and vehicle simulation, it needs to be induced quickly, if not immediately. This study examined whether vection onset latency could be reduced towards zero using visual display manipulations alone. In the main experiments, visual self-motion simulations were presented to observers via either a large external display or a head-mounted display (HMD)...
2018: PloS One
https://www.readbyqxmd.com/read/29791403/quality-enhancement-and-gpu-acceleration-for-a-full-color-holographic-system-using-a-relocated-point-cloud-gridding-method
#11
Yu Zhao, Ki-Chul Kwon, Munkh-Uchral Erdenebat, Md-Sifatul Islam, Seok-Hee Jeon, Nam Kim
The calculation of realistic full-color holographic displays is hindered by the high computational cost. Previously, we suggested a point cloud gridding (PCG) method to calculate monochrome holograms of real objects. In this research, a relocated point cloud gridding (R-PCG) method is proposed to enhance the reconstruction quality and accelerate the calculation speed in GPU for a full-color holographic system. We use a depth camera to acquire depth and color information from the real scene then reconstruct the point cloud model virtually...
May 20, 2018: Applied Optics
https://www.readbyqxmd.com/read/29791157/a-novel-hybrid-correlation-energy-hyce-approach-based-on-separate-evaluations-of-internal-and-external-components
#12
Joseph Ivanic, Michael W Schmidt
A novel Hybrid Correlation Energy (HyCE) approach is proposed that determines the total correlation energy via distinct computation of its internal and external components. This approach evolved from two related studies. First, rigorous assessment of the accuracies and size extensivities of a number of electron correlation methods, that include perturbation theory (PT2), coupled-cluster (CC), configuration interaction (CI) and coupled electron pair approximation (CEPA), shows that the CEPA(0) variant of the latter and triples-corrected CC methods consistently perform very similarly...
May 23, 2018: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29791146/effect-of-cholesterol-on-membrane-dipole-potential-atomistic-and-coarse-grained-molecular-dynamics-simulations
#13
Hujun Shen, Mingsen Deng, Zhenhua Wu, Jihua Zhang, Yachao Zhang, Chengui Gao, Chao Cen
The effect of cholesterol on membrane dipole potential has been the subject of a great number of experimental and theoretical investigations, but these studies have yielded different findings and interpretations at high cholesterol concentrations. This suggests that the underlying mechanism of the cholesterol effect is not well addressed. Moreover, as far as we know, none of the previously proposed coarse-grained (CG) models (including MARTINI and its improved versions) has been successfully used to probe the effect of cholesterol on membrane dipole potential, owing to either an inaccurate description of water-cholesterol electrostatics or the neglect of the contribution of cholesterol to membrane dipole potential...
May 23, 2018: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/29790942/exposing-the-science-in-citizen-science-fitness-to-purpose-and-intentional-design
#14
Julia K Parrish, Hillary Burgess, Jake F Weltzin, Lucy Fortson, Andrea Wiggins, Brooke Simmons
Citizen science is a growing phenomenon. With millions of people involved and billions of in-kind dollars contributed annually, this broad extent, fine grain approach to data collection should be garnering enthusiastic support in the mainstream science and higher education communities. However, many academic researchers demonstrate distinct biases against the use of citizen science as a source of rigorous information. To engage the public in scientific research, and the research community in the practice of citizen science, a mutual understanding is needed of accepted quality standards in science, and the corresponding specifics of project design and implementation when working with a broad public base...
May 21, 2018: Integrative and Comparative Biology
https://www.readbyqxmd.com/read/29789956/hepatitis-c-current-controversies-and-future-potential-in-solid-organ-transplantation
#15
REVIEW
Lucy Somerville, Karen Doucette
PURPOSE OF REVIEW: To highlight the changing landscape of hepatitis C virus (HCV) infection in the context of organ transplantation. This focuses on areas of controversy and future potential in the era of highly effective direct-acting antiviral (DAA) agents. RECENT FINDINGS: Since the advent of safe and highly effective DAA therapy, HCV infection is now curable in virtually all cases, including organ transplant recipients. Excellent drug tolerability and safety combined with high cure rates across all organ groups means that HCV is no longer a barrier to transplantation or its outcomes...
May 22, 2018: Current Infectious Disease Reports
https://www.readbyqxmd.com/read/29789932/the-cognitive-nuances-of-surprising-events-exposure-to-unexpected-stimuli-elicits-firing-variations-in-neurons-of-the-dorsal-ca1-hippocampus
#16
Ornella Valenti, Nace Mikus, Thomas Klausberger
The ability to recognize novel situations is among the most fascinating and vital of the brain functions. A hypothesis posits that encoding of novelty is prompted by failures in expectancy, according to computation matching incoming information with stored events. Thus, unexpected changes in context are detected within the hippocampus and transferred to downstream structures, eliciting the arousal of the dopamine system. Nevertheless, the precise locus of detection is a matter of debate. The dorsal CA1 hippocampus (dCA1) appears as an ideal candidate for operating a mismatch computation and discriminating the occurrence of diverse stimuli within the same environment...
May 22, 2018: Brain Structure & Function
https://www.readbyqxmd.com/read/29789704/single-cell-rna-sequencing-for-the-study-of-development-physiology-and-disease
#17
REVIEW
S Steven Potter
An ongoing technological revolution is continually improving our ability to carry out very high-resolution studies of gene expression patterns. Current technology enables the global gene expression profiles of single cells to be defined, facilitating dissection of heterogeneity in cell populations that was previously hidden. In contrast to gene expression studies that use bulk RNA samples and provide only a virtual average of the diverse constituent cells, single-cell studies enable the molecular distinction of all cell types within a complex population mix, such as a tumour or developing organ...
May 22, 2018: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/29789698/secondary-findings-in-exome-slices-virtual-panels-and-anticipatory-sequencing
#18
Leslie G Biesecker
No abstract text is available yet for this article.
May 22, 2018: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/29789520/t1-weighted-dynamic-contrast-enhanced-magnetic-resonance-imaging-dce-mri-to-distinguish-between-concurrent-cholesterol-granuloma-and-invasive-ductal-carcinoma-of-the-breast-a-case-report
#19
Cheng-Chuan Hu, Tsun-Hou Chang, Hsian-He Hsu, Yi-Jen Pen, Jyh-Cherng Yu
BACKGROUND Cholesterol granuloma is a benign condition that can be misdiagnosed as breast cancer on mammographic and ultrasound imaging. A case of concomitant cholesterol granuloma with invasive ductal carcinoma of the left breast was imaged with ultrasound elastography and magnetic resonance imaging (MRI) methods, including T1-weighted dynamic contrast-enhanced MRI (DCE-MRI), before biopsy and histopathology. CASE REPORT A 52-year-old woman, with a previous history of intraduct papillomas in both breasts, underwent six-monthly follow-up breast imaging...
May 23, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29789513/substructural-connectivity-fingerprint-and-extreme-entropy-machines-a-new-method-of-compound-representation-and-analysis
#20
Krzysztof Rataj, Wojciech Czarnecki, Sabina Podlewska, Agnieszka Pocha, Andrzej J Bojarski
Key-based substructural fingerprints are an important element of computer-aided drug design techniques. The usefulness of the fingerprints in filtering compound databases is invaluable, as they allow for the quick rejection of molecules with a low probability of being active. However, this method is flawed, as it does not consider the connections between substructures. After changing the connections between particular chemical moieties, the fingerprint representation of the compound remains the same, which leads to difficulties in distinguishing between active and inactive compounds...
May 23, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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