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https://www.readbyqxmd.com/read/28927210/navigation-and-image-injection-for-control-of-bone-removal-and-osteotomy-planes-in-spine-surgery
#1
Michael Kosterhon, Angelika Gutenberg, Sven Rainer Kantelhardt, Elefterios Archavlis, Alf Giese
BACKGROUND AND IMPORTANCE: In contrast to cranial interventions, neuronavigation in spinal surgery is used in few applications, not tapping into its full technological potential. We have developed a method to preoperatively create virtual resection planes and volumes for spinal osteotomies and export 3-D operation plans to a navigation system controlling intraoperative visualization using a surgical microscope's head-up display. The method was developed using a Sawbone ® model of the lumbar spine, demonstrating feasibility with high precision...
April 1, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/28926989/tech-savvy-beef-cattle-how-heifers-respond-to-moving-virtual-fence-lines
#2
Dana L M Campbell, Jim M Lea, William J Farrer, Sally J Haynes, Caroline Lee
Global Positioning System (GPS)-based virtual fences offer the potential to improve the management of grazing animals. Prototype collar devices utilising patented virtual fencing algorithms were placed on six Angus heifers in a 6.15 hectare paddock. After a "no fence" period, sequential, shifting virtual fences restricted the animals to 40%, 60%, and 80% of the paddock area widthways and 50% lengthways across 22 days. Audio cues signaled the virtual boundary, and were paired with electrical stimuli if the animals continued forward into the boundary...
September 18, 2017: Animals: An Open Access Journal From MDPI
https://www.readbyqxmd.com/read/28926980/indexing-natural-products-for-their-potential-anti-diabetic-activity-filtering-and-mapping-discriminative-physicochemical-properties
#3
Mouhammad Zeidan, Mahmoud Rayan, Nuha Zeidan, Mizied Falah, Anwar Rayan
Diabetes mellitus (DM) poses a major health problem, for which there is an unmet need to develop novel drugs. The application of in silico techniques and optimization algorithms is instrumental to achieving this goal. A set of 97 approved anti-diabetic drugs, representing the active domain, and a set of 2892 natural products, representing the inactive domain, were used to construct predictive models and to index anti-diabetic bioactivity. Our recently-developed approach of 'iterative stochastic elimination' was utilized...
September 17, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28926755/neochordoplasty-versus-leaflet-resection-for-ruptured-mitral-chordae-treatment-virtual-mitral-valve-repair
#4
Ahnryul Choi, David D McPherson, Hyunggun Kim
Degenerative mitral valve (MV) disease involving mitral prolapse is one of the most prevalent MV pathologies. Quadrangular leaflet resection and neochordoplasty demonstrate excellent clinical outcomes for the treatment of posterior leaflet prolapse. We evaluated the functional and biomechanical characteristics of a virtual pathologic MV model suffering from chordal rupture, performed virtual neochordoplasty and quadrangular leaflet resection, and compared the two post-repair MV functions. The pre-repair MV demonstrated severe posterior leaflet prolapse due to the ruptured P2 chordae and excessive stress concentration...
September 13, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28926370/photon-counting-computed-tomography-for-vascular-imaging-of-the-head-and-neck-first-in-vivo-human-results
#5
Rolf Symons, Daniel S Reich, Mohammadhadi Bagheri, Tyler E Cork, Bernhard Krauss, Stefan Ulzheimer, Steffen Kappler, David A Bluemke, Amir Pourmorteza
PURPOSE: The purpose of this study was to evaluate image quality of a spectral photon-counting detector (PCD) computed tomography (CT) system for evaluation of major arteries of the head and neck compared with conventional single-energy CT scans using energy-integrating detectors (EIDs). METHODS: In this institutional review board-approved study, 16 asymptomatic subjects (7 men) provided informed consent and received both PCD and EID contrast-enhanced CT scans of the head and neck (mean age, 58 years; range, 46-75 years)...
September 18, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28925981/a-new-first-break-picking-for-three-component-vsp-data-using-gesture-sensor-and-polarization-analysis
#6
Huailiang Li, Xianguo Tuo, Tong Shen, Ruili Wang, Jérémie Courtois, Minhao Yan
A new first break picking for three-component (3C) vertical seismic profiling (VSP) data is proposed to improve the estimation accuracy of first arrivals, which adopts gesture detection calibration and polarization analysis based on the eigenvalue of the covariance matrix. This study aims at addressing the problem that calibration is required for VSP data using the azimuth and dip angle of geophones, due to the direction of geophones being random when applied in a borehole, which will further lead to the first break picking possibly being unreliable...
September 19, 2017: Sensors
https://www.readbyqxmd.com/read/28925498/electronic-diary-for-recording-headaches-triggers-and-medication-use-development-and-evaluation
#7
Siavash Bandarian-Balooch, Paul R Martin, Brenton McNally, Arissa Brunelli, Sharon Mackenzie
OBJECTIVE: To evaluate an e-diary developed for measuring headaches, triggers, and medication consumption, in terms of reliability and validity, and variables such as ease of use and participant compliance. BACKGROUND: For many decades, behavioral treatment of headaches has been evaluated via participants completing paper diaries recording their headaches and associated phenomena. There is some limited evidence supporting the reliability and validity of paper diaries, and criticisms have been offered such as the large amount of effort involved for both participants and researchers...
September 19, 2017: Headache
https://www.readbyqxmd.com/read/28925395/small-molecules-targeted-to-the-microtubule-hec1-interaction-inhibit-cancer-cell-growth-through-microtubule-stabilization
#8
M Ferrara, G Sessa, M Fiore, F Bernard, I A Asteriti, E Cundari, G Colotti, S Ferla, M Desideri, S Buglioni, D Trisciuoglio, D Del Bufalo, A Brancale, F Degrassi
Highly expressed in cancer protein 1 (Hec1) is a subunit of the kinetochore (KT)-associated Ndc80 complex, which ensures proper segregation of sister chromatids at mitosis by mediating the interaction between KTs and microtubules (MTs). HEC1 mRNA and protein are highly expressed in many malignancies as part of a signature of chromosome instability. These properties render Hec1 a promising molecular target for developing therapeutic drugs that exert their anticancer activities by producing massive chromosome aneuploidy...
September 18, 2017: Oncogene
https://www.readbyqxmd.com/read/28925321/an-unusual-combination-of-truncus-arteriosus-interrupted-aortic-arch-and-hypoplastic-left-ventricle
#9
Supreet P Marathe, Sanjeev H Naganur, Sabarinath Menon, Yishay Orr, Stephen G Cooper, David S Winlaw
Truncus arteriosus (common arterial trunk) is known to be associated with interrupted aortic arch in 10% to 15% of cases. However, the association of either of these lesions with a hypoplastic left ventricle is rare. The combination of all three of these lesions along with an intact interventricular septum is virtually unknown with only two cases reported in the literature. We report such a case with its anatomical and surgical management aspects.
January 1, 2017: World Journal for Pediatric & Congenital Heart Surgery
https://www.readbyqxmd.com/read/28924869/the-educational-potential-of-youtube
#10
Haley T Godwin, Murtaza Khan, Peter Yellowlees
OBJECTIVE: The objective of this paper was to examine the educational potential and effectiveness of a 3 min video clip of a simulation of schizophrenia published online at YouTube. METHOD: Researchers examined the 267 public comments published on the video-sharing website YouTube over 8 years by viewers of a schizophrenia simulation video titled "virtual hallucinations" made in the Second Life game platform. Comments were independently categorized into six groupings, then cooperatively finalized, and qualitatively analyzed...
September 18, 2017: Academic Psychiatry
https://www.readbyqxmd.com/read/28924396/how-does-information-spread-on-social-media-lead-to-effective-change
#11
REVIEW
Thomas K Varghese
Social media encompasses computer-mediated technologies that facilitate the creation and sharing of information, ideas, and other forms of expression via virtual communities and networks. The key, of course, is the ability and willingness for information to be shared. But why does some information spread on social media and not others? What factors translate social media awareness to action? In this article, we explore these themes using case studies, as well as tips on how you can utilize social media to effectively champion a cause...
September 2017: Clinics in Colon and Rectal Surgery
https://www.readbyqxmd.com/read/28924395/history-of-social-media-in-surgery
#12
REVIEW
Heather J Logghe, Cedrek L McFadden, Natalie J Tully, Christian Jones
In many ways, the history of surgeons on Twitter echoes the initial resistance and ultimate mass adoption of laparoscopic surgery that led to the field of minimally invasive surgery. At its inception, social media was similarly met with skepticism and concerns of threats to professionalism. Despite these concerns, numerous surgeons and other physicians pioneered the use of social media to establish a virtual medical community and share scientific knowledge regarding a variety of topics including medical conferences, journal publications, and more...
September 2017: Clinics in Colon and Rectal Surgery
https://www.readbyqxmd.com/read/28924330/manufacturing-data-analytics-using-a-virtual-factory-representation
#13
Sanjay Jain, Guodong Shao, Seung-Jun Shin
Large manufacturers have been using simulation to support decision-making for design and production. However, with the advancement of technologies and the emergence of big data, simulation can be utilised to perform and support data analytics for associated performance gains. This requires not only significant model development expertise, but also huge data collection and analysis efforts. This paper presents an approach within the frameworks of Design Science Research Methodology and prototyping to address the challenge of increasing the use of modelling, simulation and data analytics in manufacturing via reduction of the development effort...
2017: International Journal of Production Economics
https://www.readbyqxmd.com/read/28924283/a-framework-for-laparoscopic-simulations
#14
Osman Hasan, Sohail Iqbal
Due to their numerous advantages, laparoscopic surgical procedures are increasingly becoming common in the operation theatres over the past few decades. Virtual reality training simulators have played a significant role during this transition from traditional to laparoscopic procedures by enhancing surgical skills, such as hand-eye coordination in laparoscopy, and practising surgical scenarios that cannot be easily created using physical models. This paper presents a general framework for such a training simulator while identifying its key components and their specific roles in enhancing various laparoscopic skills...
September 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28923920/microrna-dysregulation-to-identify-therapeutic-target-combinations-for-chronic-lymphocytic-leukemia
#15
Laura Z Rassenti, Veronica Balatti, Emanuela M Ghia, Alexey Palamarchuk, Luisa Tomasello, Paolo Fadda, Yuri Pekarsky, George F Widhopf, Thomas J Kipps, Carlo M Croce
Loss of miR-15/16 is the most common genetic lesion in chronic lymphocytic leukemia (CLL), promoting overexpression of BCL2, which factors in leukemia pathogenesis. Indeed, an inhibitor of Bcl2, venetoclcax, is highly active in the treatment of patients with CLL. However, single-agent venetoclcax fails to eradicate minimal residual disease in most patients. Accordingly, we were interested in other genes that may be regulated by miR-15/16, which may target other drivers in CLL. We found that miR-15/16 targets ROR1, which encodes an onco-embryonic surface protein expressed on the CLL cells of over 90% of patients, but not on virtually all normal postpartum tissues...
September 18, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28923538/three-dimensional-nano-architected-scaffolds-with-tunable-stiffness-for-efficient-bone-tissue-growth
#16
Alessandro Maggi, Hanqing Li, Julia R Greer
The precise mechanisms that lead to orthopedic implant failure are not well understood; it is believed that the micromechanical environment at the bone-implant interface regulates structural stability of an implant. In this work, we seek to understand how the 3D mechanical environment of an implant affects bone formation during early osteointegration. We employed two-photon lithography (TPL) direct laser writing to fabricate 3-dimensional rigid polymer scaffolds with tetrakaidecahedral periodic geometry, herewith referred to as nanolattices, whose strut dimensions were on the same order as osteoblasts' focal adhesions (∼2μm) and pore sizes on the order of cell size, ∼10μm...
September 15, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28923473/virtual-surgery-for-patients-with-nasal-obstruction-use-of-computational-fluid-dynamics-mecomland-%C3%A2-digbody-%C3%A2-noseland-%C3%A2-to-document-objective-flow-parameters-and-optimise-surgical-results
#17
Manuel A Burgos, Maria Agustina Sevilla García, Enrique Sanmiguel Rojas, Carlos Del Pino, Carlos Fernández Velez, Francisco Piqueras, Francisco Esteban Ortega
INTRODUCTION: Computational fluid dynamics (CFD) is a mathematical tool to analyse airflow. We present a novel CFD software package to improve results following nasal surgery for obstruction. METHODS: A group of engineers in collaboration with otolaryngologists have developed a very intuitive CFD software package called MeComLand®, which uses the patient's cross-sectional (tomographic) images, thus showing in detail results originated by CFD such as airflow distributions, velocity profiles, pressure, or wall shear stress...
September 15, 2017: Acta Otorrinolaringológica Española
https://www.readbyqxmd.com/read/28923292/promising-non-pharmacological-therapies-in-pd-targeting-late-stage-disease-and-the-role-of-computer-based-cognitive-training
#18
S C F Van de Weijer, A L A J Hommel, B R Bloem, J Nonnekes, N M De Vries
Non-pharmacological interventions are increasingly being acknowledged as valuable treatment options to overcome or reduce functional problems in patients with Parkinson's disease (PD). There is a wide range of such non-pharmacological treatments for which the supportive evidence is emerging. Physiotherapy is one good example in this domain. However, there are also several promising non-pharmacological treatment strategies that have thus far received less research attention. Here, we describe two relatively new, but encouraging approaches...
September 4, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28923199/associations-of-short-sleep-duration-with-childhood-obesity-and-weight-gain-summary-of-a-presentation-to-the-national-academy-of-science-s-roundtable-on-obesity-solutions
#19
Tayla Ash, Elsie M Taveras
This article summarizes a presentation made in February 2017 as part of the National Academy of Sciences' Roundtable on Obesity Solutions webinar, "The Potential Role of Sleep in Obesity Prevention and Management: A Virtual Workshop." Briefly described are the patterns of childhood sleep duration in the United States, the state of the science relating insufficient sleep to overweight and obesity in infancy and early childhood, and the potential mechanisms for the association. Also discussed are intervention efforts to date...
October 2017: Sleep Health
https://www.readbyqxmd.com/read/28923196/the-potential-role-of-sleep-in-obesity-prevention-and-management-a-virtual-workshop-webinar
#20
EDITORIAL
Amanda M Nguyen
No abstract text is available yet for this article.
October 2017: Sleep Health
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