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https://www.readbyqxmd.com/read/28544750/unexpected-ethical-dilemmas-in-sex-assignment-in-46-xy-dsd-due-to-5-alpha-reductase-type-2-deficiency
#1
Heather M Byers, Lauren H Mohnach, Patricia Y Fechner, Ming Chen, Inas H Thomas, Linda A Ramsdell, Margarett Shnorhavorian, Elizabeth A McCauley, Anne-Marie E Amies Oelschlager, John M Park, David E Sandberg, Margaret P Adam, Catherine E Keegan
Sex assignment at birth remains one of the most clinically challenging and controversial topics in 46,XY disorders of sexual development (DSD). This is particularly challenging in deficiency of 5-alpha reductase type 2 given that external genitalia are typically undervirilized at birth but typically virilize at puberty to a variable degree. Historically, most individuals with 5-alpha reductase deficiency were raised females. However, reports that over half of patients who underwent a virilizing puberty adopted an adult male gender identity have challenged this practice...
May 25, 2017: American Journal of Medical Genetics. Part C, Seminars in Medical Genetics
https://www.readbyqxmd.com/read/28532433/partnering-with-women-collectives-for-delivering-essential-women-s-nutrition-interventions-in-tribal-areas-of-eastern-india-a-scoping-study
#2
Vani Sethi, Arti Bhanot, Surbhi Bhalla, Sourav Bhattacharjee, Abner Daniel, Deepika Mehrish Sharma, Rajkumar Gope, Saba Mebrahtu
BACKGROUND: We examined the feasibility of engaging women collectives in delivering a package of women's nutrition messages/services as a funded stakeholder in three tribal-dominated districts of Odisha, Jharkhand and Chhattisgarh States, in eastern India. These districts have high prevalence of child stunting and poor government service outreach. METHODS: Conducted between July 2014 and March 2015, an exploratory mix-methods design was adopted (review of coverage data and government reports, field interviews and focus group discussion with multiple stakeholders and intended communities) to assess coverage of women's nutrition services...
May 22, 2017: Journal of Health, Population, and Nutrition
https://www.readbyqxmd.com/read/28525577/moving-triadic-gaze-intervention-into-practice-measuring-clinician-attitude-and-implementation-fidelity
#3
Julie Feuerstein, Lesley B Olswang, Kathryn Greenslade, Gay Lloyd Pinder, Patricia Dowden, Jodi Madden
Purpose: This research investigated a first step in implementing the dynamic assessment (DA) component of Triadic Gaze Intervention (Olswang, Feuerstein, Pinder, & Dowden, 2013; Olswang et al., 2014), an evidence-based protocol for teaching early signals of communication to young children with physical disabilities. Clinician attitudes about adopting external evidence into practice and implementation fidelity in DA protocol delivery were examined following training. Method: Seven early intervention clinicians from multiple disciplines were trained to deliver the four essential elements of the DA protocol: (a) provide communication opportunity, (b) recognize child's potentially communicative signal, (c) shape child's signal toward triadic gaze, and (d) reinforce with play...
May 24, 2017: Journal of Speech, Language, and Hearing Research: JSLHR
https://www.readbyqxmd.com/read/28521186/timely-diagnosis-of-sitosterolemia-by-next-generation-sequencing-in-two-children-with-severe-hypercholesterolemia
#4
Paola Sabrina Buonuomo, Lorenzo Iughetti, Livia Pisciotta, Claudio Rabacchi, Francesco Papadia, Patrizia Bruzzi, Albina Tummolo, Andrea Bartuli, Claudio Cortese, Stefano Bertolini, Sebastiano Calandra
BACKGROUND AND AIMS: Severe hypercholesterolemia associated or not with xanthomas in a child may suggest the diagnosis of homozygous autosomal dominant hypercholesterolemia (ADH), autosomal recessive hypercholesterolemia (ARH) or sitosterolemia, depending on the transmission of hypercholesterolemia in the patient's family. Sitosterolemia is a recessive disorder characterized by high plasma levels of cholesterol and plant sterols due to mutations in the ABCG5 or the ABCG8 gene, leading to a loss of function of the ATP-binding cassette (ABC) heterodimer transporter G5-G8...
May 4, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28511689/harnessing-interactive-technologies-to-improve-health-outcomes-in-juvenile-idiopathic-arthritis
#5
REVIEW
Andrea Coda, Dean Sculley, Derek Santos, Xavier Girones, Lucie Brosseau, Derek R Smith, Joshua Burns, Keith Rome, Jane Munro, Davinder Singh-Grewal
BACKGROUND: Children and adolescents with Juvenile Idiopathic Arthritis (JIA) typically have reduced physical activity level and impaired aerobic and anaerobic exercise capacity when compared to their non-JIA counterparts. Low intensity exercise regimens appear to be safe in children with JIA and may results in improvements in overall physical function. Poor adherence to paediatric rheumatology treatment may lead to negative clinical outcomes and possibly increased disease activity. This includes symptoms such as pain, fatigue, quality of life, longer term outcomes including joint damage, as well as increase of healthcare associated costs...
May 16, 2017: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/28499483/-an-adopted-family-for-kath%C3%A3-rina
#6
Martine Terraz
A foster mother took into her home Kathérina, a 5-month-old girl placed by the child welfare services. Before taking the decision, she discussed it with her partner and her own children. Straight after Kathérina's arrival, visits were organised in order to maintain, as much as possible, the child's bond with her mother.
May 2017: Soins. Pédiatrie, Puériculture
https://www.readbyqxmd.com/read/28498183/impact-of-facility-and-community-based-peer-support-models-on-maternal-uptake-and-retention-in-malawi-s-option-b-hiv-prevention-of-mother-to-child-transmission-program-a-3-arm-cluster-randomized-controlled-trial-pure-malawi
#7
Sam Phiri, Hannock Tweya, Monique van Lettow, Nora E Rosenberg, Clement Trapence, Atupele Kapito-Tembo, Blessings Kaunda-Khangamwa, Florence Kasende, Virginia Kayoyo, Fabian Cataldo, Christopher Stanley, Salem Gugsa, Veena Sampathkumar, Erik Schouten, Levison Chiwaula, Michael Eliya, Frank Chimbwandira, Mina C Hosseinipour
BACKGROUND: Many sub-Saharan African countries have adopted Option B+, a prevention of mother-to-child transmission approach providing HIV-infected pregnant and lactating women with immediate lifelong antiretroviral therapy. High maternal attrition has been observed in Option B+. Peer-based support may improve retention. METHODS: A 3-arm stratified cluster randomized controlled trial was conducted in Malawi to assess whether facility- and community-based peer support would improve Option B+ uptake and retention compared with standard of care (SOC)...
June 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28482854/medical-decision-making-in-children-and-adolescents-developmental-and-neuroscientific-aspects
#8
REVIEW
Petronella Grootens-Wiegers, Irma M Hein, Jos M van den Broek, Martine C de Vries
BACKGROUND: Various international laws and guidelines stress the importance of respecting the developing autonomy of children and involving minors in decision-making regarding treatment and research participation. However, no universal agreement exists as to at what age minors should be deemed decision-making competent. Minors of the same age may show different levels of maturity. In addition, patients deemed rational conversation-partners as a child can suddenly become noncompliant as an adolescent...
May 8, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28480995/aplasia-cutis-congenita-type-v-a-case-report-and-review-of-the-literature
#9
REVIEW
Benjamin M Perry, Cory B Maughan, Matthew S Crosby, Scott D Hadenfeld
Aplasia cutis congenita (ACC) is a relatively rare congenital anomaly that most commonly occurs as a solitary cutaneous defect on the scalp. Depth of involvement varies, and involvement of deeper calvarium and dural structures can be seen in more severe cases. Multiple classification systems have been devised with the Frieden Classification System being the most widely adopted. Using this system, we describe a patient that developed Type V ACC with associated fetal papyraceous. The child healed remarkably well with the application of petrolatum impregnated gauze and topical silver sulfadiazine twice daily for approximately 4 weeks...
May 8, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28479883/raising-a-child-with-down-s-syndrome-perspectives-from-south-african-urban-care-givers
#10
Megan D Barr, Pragashnie Govender, Gina Rencken
OBJECTIVES: This study addresses a gap from a South African urban perspective on the knowledge and emotional responses of caregivers with children diagnosed with Down's syndrome (DS). The study is an initial step towards informing health professionals who adopt a biopsychosocial approach, in an effort to improve interventions for both caregivers and children. METHODS: A simple descriptive survey was utilized with 57 participants who were caregivers of children with DS...
December 2016: African Health Sciences
https://www.readbyqxmd.com/read/28476100/behavioral-antecedents-for-handwashing-in-a-low-income-urban-setting-in-bangladesh-an-exploratory-study
#11
Musarrat J Rahman, Fosiul A Nizame, Leanne Unicomb, Stephen P Luby, Peter J Winch
BACKGROUND: Health programs commonly promote handwashing by drawing attention to potential fecal contamination in the environment. The underlying assumption is that the thought of fecal contamination will result in disgust, and motivate people to wash their hands with soap. However, this has not proven sufficient to achieve high rates of handwashing with soap at key times. We argue that handwashing with soap is influenced by broader range of antecedents, many unrelated to fecal contamination, that indicate to people when and where to wash their hands...
May 5, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28474585/introduction-of-new-vaccines-in-state-immunization-schedule-delhi-s-experience
#12
Amita Raoot, Dharmendra Kumar Dewan, A P Dubey, Suresh Seth
Immunization is an established, cost-effective, preventive intervention to improve child survival. To provide protection against vaccine preventable diseases, all countries in the world have an immunization program that offers selected vaccines to the eligible beneficiaries. In India, Expanded Program of Immunization was started in 1978, and then Universal Immunization Program was launched in 1985 with six antigens. This article describes the experience with institutionalization of four state-specific vaccines by Delhi in its immunization schedule to enlarge the ambit of immunization services...
April 15, 2017: Indian Pediatrics
https://www.readbyqxmd.com/read/28466627/predictors-of-parents-adherence-to-home-exercise-programs-for-children-with-developmental-disabilities-regarding-both-exercise-frequency-and-duration-a-survey-design
#13
Francesc Medina-Mirapeix, Carmen Lillo-Navarro, Joaquina Montilla-Herrador, Mariano Gacto-Sanchez, María Á Franco-Sierra, Pilar Escolar-Reina
BACKGROUND: Many families have problems adhering to home exercise programs (HEP) for children with developmental disabilities. However, parental participation in HEP is known to have a positive effect on child-related outcome variables, as well as on parental functioning. AIM: This study examined whether the different behaviours of health professionals, and the behaviour and social characteristics of parents determine rates of parental adherence to both the frequency per week, and duration per session, of HEP for children with developmental disabilities attending paediatric services in early intervention centres...
May 2, 2017: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/28463943/diaper-slit-perineal-bag-urine-sampling
#14
Sody A Naimer
OBJECTIVE: Many indications justifiably drive the pediatrician to request a urine sample in order to assess the health status of the incontinent baby or infant. Urine collection by means of an adhesive perineal bag is the most widely used in children who do not control urine emission, despite its inaccurate reflection of bacteriuria. We suggest a novel technique to immediately visualize the micturition event upon occurrence, in attempt to shorten waiting times and exhausting checking and rechecking opaque diapers in order to determine whether the desired sample has finally been delivered...
May 1, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28461761/managing-the-pediatric-patient-with-refractory-asthma-a-multidisciplinary-approach
#15
REVIEW
James Cook, Fran Beresford, Valentina Fainardi, Pippa Hall, Georgie Housley, Angela Jamalzadeh, Michelle Nightingale, David Winch, Andrew Bush, Louise Fleming, Sejal Saglani
Children with asthma that is refractory to high levels of prescribed treatment are described as having problematic severe asthma. Those in whom persistent symptoms result from a failure of basic asthma management are described as having "difficult asthma", while those who remain symptomatic despite these factors having been addressed are described as having "severe therapy-resistant asthma" (STRA). The majority of children have difficult asthma; asthma that is poorly controlled because of a failure to get the basics of asthma management right...
2017: Journal of Asthma and Allergy
https://www.readbyqxmd.com/read/28461197/child-feeding-style-is-associated-with-food-intake-and-linear-growth-in-rural-ethiopia
#16
Zeweter Abebe, Gulelat Desse Haki, Kaleab Baye
BACKGROUND: Little is known about mother-child feeding interactions and how this is associated with food intake and linear growth. OBJECTIVE: To characterize mother-child feeding styles and investigate their associations with accepted mouthful and linear growth in west Gojam, rural Ethiopia. SUBJECTS/DESIGN: Two, in-home, meal observations of children aged 12-23 months (n = 100) were video-taped. The number of mouthful accepted was counted and the caregiver/child feeding styles were coded into positive/negative categories of self-feeding, responsive-feeding, active-feeding, social-behavior and distraction...
April 29, 2017: Appetite
https://www.readbyqxmd.com/read/28458148/postural-control-strategies-differ-in-normal-weight-and-overweight-infants
#17
Danae Dinkel, Kailey Snyder, Victoria Molfese, Anastasia Kyvelidou
BACKGROUND: Evidence suggests obesity can have a negative influence on a child's motor development and postural control behavior. Little research has examined the impact of infant weight on gross motor behavior, particularly postural control at the onset of sitting. OBJECTIVE: The purpose of this study was to determine whether normal weight and overweight infants differed in their postural control strategies at the onset of sitting and one-month post onset of sitting...
April 13, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28455800/global-trends-in-paediatric-robot-assisted-urological-surgery-a-bibliometric-and-progressive-scholarly-acceptance-analysis
#18
Thomas P Cundy, Simon J D Harley, Hani J Marcus, Archie Hughes-Hallett, Sanjeev Khurana
The inaugural robot-assisted urological procedure in a child was performed in 2002. This study aims to catalogue the impact of this technology by utilizing bibliographic data as a surrogate measure for global diffusion activity and to appraise the quality of evidence in this field. A systematic literature search was performed to retrieve all reported cases of paediatric robot-assisted urological surgery published between 2003 and 2016. The status of scientific community acceptance was determined using a newly developed analysis model named progressive scholarly acceptance...
April 28, 2017: Journal of Robotic Surgery
https://www.readbyqxmd.com/read/28446232/continuous-quality-improvement-interventions-to-improve-long-term-outcomes-of-antiretroviral-therapy-in-women-who-initiated-therapy-during-pregnancy-or-breastfeeding-in-the-democratic-republic-of-congo-design-of-an-open-label-parallel-group-randomized-trial
#19
Marcel Yotebieng, Frieda Behets, Bienvenu Kawende, Noro Lantoniaina Rosa Ravelomanana, Martine Tabala, Emile W Okitolonda
BACKGROUND: Despite the rapid adoption of the World Health Organization's 2013 guidelines, children continue to be infected with HIV perinatally because of sub-optimal adherence to the continuum of HIV care in maternal and child health (MCH) clinics. To achieve the UNAIDS goal of eliminating mother-to-child HIV transmission, multiple, adaptive interventions need to be implemented to improve adherence to the HIV continuum. METHODS: The aim of this open label, parallel, group randomized trial is to evaluate the effectiveness of Continuous Quality Improvement (CQI) interventions implemented at facility and health district levels to improve retention in care and virological suppression through 24 months postpartum among pregnant and breastfeeding women receiving ART in MCH clinics in Kinshasa, Democratic Republic of Congo...
April 26, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28436297/health-impact-assessment-hia-of-political-proposals-at-the-local-level-successful-introduction-but-what-has-happened-15-years-later
#20
Karin Berensson, Per Tillgren
Health impact assessments (HIAs) were first introduced in Sweden in the mid-to-late 1990s, with the aim of placing health issues on the political agenda and helping to reduce health inequalities. In the early 2000s, HIAs entered a second phase and the Swedish Parliament adopted a national public health policy. A national survey conducted in 2001 showed that 10/289 municipalities had begun to use HIA and 55/289 had decided to use HIA or had initiated an adoption process. In a 2013 follow-up study based on a strategic sample of municipalities, 9/36 municipalities reported using HIA and/or similar tools...
April 1, 2017: Global Health Promotion
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