Julian Kingsley, Omneya Kandil, Joshua Satalin, Akram Abdel Bary, Sierra Coyle, Mahmoud Saad Nawar, Robert Groom, Amr Farrag, Jaffer Shah, Ben R Robedee, Edward Darling, Ahmed Shawkat, Debanik Chaudhuri, Gary F Nieman, Hani Aiash
Acute respiratory failure (ARF) strikes an estimated two million people in the United States each year, with care exceeding US$50 billion. The hallmark of ARF is a heterogeneous injury, with normal tissue intermingled with a large volume of low compliance and collapsed tissue. Mechanical ventilation is necessary to oxygenate and ventilate patients with ARF, but if set inappropriately, it can cause an unintended ventilator-induced lung injury (VILI). The mechanism of VILI is believed to be overdistension of the remaining normal tissue known as the 'baby' lung, causing volutrauma, repetitive collapse and reopening of lung tissue with each breath, causing atelectrauma, and inflammation secondary to this mechanical damage, causing biotrauma...
January 19, 2024: Perfusion