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https://www.readbyqxmd.com/read/28102840/cancer-associated-fibroblasts-enact-field-cancerization-by-promoting-extratumoral-oxidative-stress
#1
Jeremy Soon Kiat Chan, Ming Jie Tan, Ming Keat Sng, Ziqiang Teo, Terri Phua, Chee Chong Choo, Liang Li, Pengcheng Zhu, Nguan Soon Tan
Histological inspection of visually normal tissue adjacent to neoplastic lesions often reveals multiple foci of cellular abnormalities. This suggests the presence of a regional carcinogenic signal that spreads oncogenic transformation and field cancerization. We observed an abundance of mutagenic reactive oxygen species in the stroma of cryosectioned patient tumor biopsies, indicative of extratumoral oxidative stress. Diffusible hydrogen peroxide (H2O2) was elevated in the conditioned medium of cultured skin epithelia at various stages of oncogenic transformation, and H2O2 production increased with greater tumor-forming and metastatic capacity of the studied cell lines...
January 19, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28100410/comp-serum-levels-a-new-non-invasive-biomarker-of-liver-fibrosis-in-patients-with-chronic-viral-hepatitis
#2
Kalliopi Zachou, Stella Gabeta, Zakera Shums, Nikolaos K Gatselis, George K Koukoulis, Gary L Norman, George N Dalekos
BACKGROUND & AIMS: Recently we have shown that cartilage oligomeric matrix protein (COMP), a fibrillar collagen assembly regulator, is strongly associated with cirrhosis and hepatocellular carcinoma progression. Therefore, we assessed whether serum COMP levels can be used as a non-invasive fibrosis marker in patients with chronic viral hepatitis (CVH) and compared this marker with standard methods for disease stage assessment [histology, transient elastography (TE), APRI, FIB-4]. METHODS: Sera from 116 CVH patients, 66 HBV [24 female; median age 53(22-76)] and 50 HCV [21 female; median age 48...
January 15, 2017: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/28100376/-related-factors-for-severe-liver-fibrosis-in-chronic-hepatitis-c-patients-with-remunerated-blood-donation-history-in-jurong-of-jiangsu-province
#3
Y N Yao, P Huang, H B Chen, L Zhang, M Z Chen, R B Yu
Objective: The incidence of liver fibrosis in patients with chronic hepatitis C is high. Without effective treatment, it would lead to liver cirrhosis. This study is to identify the related factors for the incidence of liver fibrosis in patients with chronic hepatitis C in order to make early intervention treatment and reduce the case fatality rate. Methods: This cross-sectional survey was conducted in adults aged ≥50 years with local residence for more than 5 years in Jurong of Jiangsu province from March to May in 2015, the patients infected with hepatitis C virus through remunerated blood donation were screened and included in the analysis...
January 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28094314/reassessment-of-rebleeding-risk-of-forrest-ib-oozing-peptic-ulcer-bleeding-in-a-large-international-randomized-trial
#4
Dennis M Jensen, Stefan Eklund, Tore Persson, Henrik Ahlbom, Robert Stuart, Alan N Barkun, Ernest J Kuipers, Joachim Mössner, James Y Lau, Joseph J Sung, Jan Kilhamn, Tore Lind
OBJECTIVES: Our aims were to assess risks of early rebleeding after successful endoscopic hemostasis for Forrest oozing (FIB) peptic ulcer bleeding (PUBs) compared with other stigmata of recent hemorrhage (SRH). METHODS: These were post hoc multivariable analyses of a large, international, double-blind study (NCT00251979) of patients randomized to high-dose intravenous (IV) esomeprazole (PPI) or placebo for 72 h. Rebleeding rates of patients with PUB SRH treated with either PPI or placebo after successful endoscopic hemostasis were also compared...
January 17, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28086824/d-dimer-is-an-essential-accompaniment-of-circulating-tumor-cells-in-gastric-cancer
#5
Dongmei Diao, Yao Cheng, Yongchun Song, Hao Zhang, Zhangjian Zhou, Chengxue Dang
BACKGROUND: Fibrinogen (FIB) is an important source of fibrin, which plays a crucial role in circulating tumor cells (CTCs) extravasation and distant metastasis development. We hypothesize it's stable final product, plasma D-dimer, may be associated with CTCs appearance and can reflect the metastatic phenotype in cancer patients. METHODS: We first verified our hypothesis in different murine gastric cancer metastasis models in vivo, plasma D-dimer and fibrinogen as well as its degradation products were directly examined in three metastasis immune-deficient mouse models and in controls...
January 13, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28077090/gbs-based-single-dosage-markers-for-linkage-and-qtl-mapping-allow-gene-mining-for-yield-related-traits-in-sugarcane
#6
Thiago Willian Almeida Balsalobre, Guilherme da Silva Pereira, Gabriel Rodrigues Alves Margarido, Rodrigo Gazaffi, Fernanda Zatti Barreto, Carina Oliveira Anoni, Cláudio Benício Cardoso-Silva, Estela Araújo Costa, Melina Cristina Mancini, Hermann Paulo Hoffmann, Anete Pereira de Souza, Antonio Augusto Franco Garcia, Monalisa Sampaio Carneiro
BACKGROUND: Sugarcane (Saccharum spp.) is predominantly an autopolyploid plant with a variable ploidy level, frequent aneuploidy and a large genome that hampers investigation of its organization. Genetic architecture studies are important for identifying genomic regions associated with traits of interest. However, due to the genetic complexity of sugarcane, the practical applications of genomic tools have been notably delayed in this crop, in contrast to other crops that have already advanced to marker-assisted selection (MAS) and genomic selection...
January 11, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28076759/quantitative-in-situ-tem-nanotensile-testing-of-single-crystal-ni-facilitated-by-a-new-sample-preparation-approach
#7
Vahid Samaeeaghmiyoni, Hosni Idrissi, Jonas Groten, Ruth Schwaiger, Dominique Schryvers
Twin-jet electro-polishing and Focused Ion Beam (FIB) were combined to produce small size Nickel single crystal specimens for quantitative in-situ nanotensile experiments in the transmission electron microscope. The combination of these techniques allows producing samples with nearly defect-free zones in the centre in contrast to conventional FIB-prepared samples. Since TEM investigations can be performed on the electro-polished samples prior to in-situ TEM straining, specimens with desired crystallographic orientation and initial microstructure can be prepared...
December 21, 2016: Micron: the International Research and Review Journal for Microscopy
https://www.readbyqxmd.com/read/28074963/ultrahigh-capacity-dynamic-holographic-displays-via-anisotropic-nanoholes
#8
Xiaohu Zhang, Jinjin Jin, Mingbo Pu, Xiong Li, Xiaoliang Ma, Ping Gao, Zeyu Zhao, Yanqin Wang, Changtao Wang, Xiangang Luo
For the miniaturization of optical holographic and data recording devices, large information capacity or data density is indispensable but difficult to obtain using traditional technologies. In this paper, an ultrahigh-capacity metasurface hologram is proposed by encoding information in deep-subwavelength scale nanohole arrays, which can be reconstructed via a light beam with proper designed incident angles. The imaging information capacity of the two-dimensional (2D) hologram, defined by the distortion-free region, can be increased 11...
January 11, 2017: Nanoscale
https://www.readbyqxmd.com/read/28073267/folding-sheets-with-ion-beams
#9
Cheng-Lun Wu, Fang-Cheng Li, Chun-Wei Pao, David J Srolovitz
Focused ion beams (FIBs) are versatile tools with cross-disciplinary applications from the physical and life sciences to archeology. Nevertheless, the nanoscale patterning precision of FIBs is often accompanied by defect formation and sample deformation. In this study, the fundamental mechanisms governing the large-scale plastic deformation of nanostructures undergoing FIB processes are revealed by a series of molecular dynamic simulations. A surprisingly simple linear correlation between atomic volume removed from the film bulk and film deflection angle, regardless of incident ion energy and current, is revealed, demonstrating that the mass transport to the surface of material caused by energetic ion bombardment is the primary cause leading to nanostructure deformation...
January 11, 2017: Nano Letters
https://www.readbyqxmd.com/read/28070899/sofosbuvir-based-treatment-regimens-real-life-results-of-14-409-chronic-hcv-genotype-4-patients-in-egypt
#10
A Elsharkawy, R Fouad, W El Akel, M El Raziky, M Hassany, G Shiha, M Said, I Motawea, T El Demerdash, S Seif, A Gaballah, Y El Shazly, M A M Makhlouf, I Waked, A O Abdelaziz, A Yosry, M El Serafy, M Thursz, W Doss, G Esmat
BACKGROUND: Chronic hepatitis C virus infection is one of the most important health problems in Egypt. The Ministry of Health's National Treatment Programme introduced sofosbuvir-based therapy in October 2014. AIM: To assess the clinical effectiveness and predictors of response to SOF-based treatment regimens, either dual therapy, with SOF/ribavirin (RBV) for 6 months or triple therapy with SOF/peg-IFN-alfa-2a/RBV for 3 months, in a cohort of patients treated in National Treatment Programme affiliated centres in Egypt...
January 9, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28070199/performance-and-utility-of-transient-elastography-and-non-invasive-markers-of-liver-fiibrosis-in-patients-with-autoimmune-hepatitis-a-single-centre-experience
#11
Olympia E Anastasiou, Matthias Büchter, Hideo A Baba, Johannes Korth, Ali Canbay, Guido Gerken, Alisan Kahraman
OBJECTIVES: Autoimmune hepatitis (AIH) is a relatively rare cause of hepatic dysfunction, which can lead to acute liver failure (ALV) and cirrhosis if not treated. The performance of transient elastography (TE) compared to liver biopsy has been evaluated in many liver diseases. The aim of the present study was to evaluate the performance of TE and other non-invasive markers for liver fiibrosis in patients with biopsy-proven AIH. METHODS: Fifty-three patients who were treated at the department of gastroenterology and hepatology of the University Clinic Essen from 2008 to 2013 included in this retrospective study...
November 2016: Hepatitis Monthly
https://www.readbyqxmd.com/read/28067683/acoustic-radiation-force-impulse-elastography-comparison-and-combination-with-other-noninvasive-tests-for-the-diagnosis-of-compensated-liver-cirrhosis
#12
Lukas Pfeifer, Werner Adler, Steffen Zopf, Jürgen Siebler, Dane Wildner, Ruediger S Goertz, Barbara Schellhaas, Markus F Neurath, Deike Strobel
BACKGROUND AND AIMS: The aim of this study was to compare acoustic radiation force impulse (ARFI) elastography with other noninvasive tests and to develop a new score for the assessment of liver fibrosis/cirrhosis. MATERIALS AND METHODS: B-mode ultrasound (including high-frequency liver surface evaluation), routine blood tests, ARFI quantification, and mini-laparoscopic liver evaluation were obtained in compensated patients scheduled for mini-laparoscopic biopsy...
January 6, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28062041/improved-force-spectroscopy-using-focused-ion-beam-modified-cantilevers
#13
J K Faulk, D T Edwards, M S Bull, T T Perkins
Atomic force microscopy (AFM) is widely used in biophysics, including force-spectroscopy studies of protein folding and protein-ligand interactions. The precision of such studies increases with improvements in the underlying quality of the data. Currently, data quality is limited by the mechanical properties of the cantilever when using a modern commercial AFM. The key tradeoff is force stability vs short-term force precision and temporal resolution. Here, we present a method that avoids this compromise: efficient focused-ion-beam (FIB) modification of commercially available cantilevers...
2017: Methods in Enzymology
https://www.readbyqxmd.com/read/28060754/diagnostic-value-of-fib-4-for-liver-fibrosis-in-patients-with-hepatitis-b-a-meta-analysis-of-diagnostic-test
#14
Zhi Yin, Jin Zou, Qiongxuan Li, Lizhang Chen
This study is aimed at evaluating the diagnostic value of FIB-4 for liver fibrosis in patients with hepatitis B through a meta-analysis of diagnostic test. We conducted a comprehensive search in the Pubmed, Embase, Web of Science, and Chinese National Knowledge Infrastructure before October 31, 2016. Stata 14.0 software was used for calculation and statistical analyses. We used the sensitivity, specificity, positive and negative likelihood ratio (PLR, NLR), diagnostic odds ratio (DOR) and 95% confidence intervals (CIs) to evaluate the diagnostic value of FIB-4 for liver fibrosis in patients with hepatitis B...
January 2, 2017: Oncotarget
https://www.readbyqxmd.com/read/28059278/wavelength-tunable-ultrafast-fiber-laser-via-reflective-mirror-with-taper-structure
#15
Li Fang, Chuyun Huang, Ting Liu, Noelle Gogneau, Eric Bourhis, Jacques Gierak, Jean-Louis Oudar
Laser sources with a controllable flexible wavelength have found widespread applications in optical fiber communication, optical sensing, and microscopy. Here, we report a tunable mode-locked fiber laser using a graphene-based saturable absorber and a tapered mirror as an end mirror in the cavity. The phase layer in the mirror is precisely etched by focused ion beam (FIB) milling technology, and the resonant wavelength of the mirror shifts correspond to the different etch depths. By scanning the tapered mirror mechanically, the center wavelength of a mode-locked fiber laser can be continuously tuned from 1562 to 1532 nm, with a pulse width in the sub-ps level and repetition rate of 27 MHz...
December 20, 2016: Applied Optics
https://www.readbyqxmd.com/read/28045005/silicon-dioxide-mask-by-plasma-enhanced-atomic-layer-deposition-in-focused-ion-beam-lithography
#16
Zhengjun Liu, Ali Shah, Tapani Alasaarela, Nikolai Chekurov, Hele Savin, IIkka Tittonen
In this work, focused ion beam (FIB) lithography was developed for plasma enhanced atomic layer deposited (PEALD) silicon dioxide SiO<sub>2</sub> hard mask. The PEALD process greatly decreases the deposition temperature of the SiO<sub>2</sub> hard mask. FIB Ga<sup>+</sup> ion implantation on the deposited SiO<sub>2</sub> layer increases the wet etch resistivity of the irradiated region. A programmed exposure in FIB followed by development in a wet etchant enables the precisely defined nanoscale patterning...
January 3, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28040888/a-seasonal-assessment-of-opportunistic-premise-plumbing-pathogens-in-roof-harvested-rainwater-tanks
#17
Kerry A Hamilton, Warish Ahmed, Andrew Palmer, Kylie Smith, Simon Toze, Charles N Haas
A seasonal study on the occurrence of six opportunistic premise plumbing pathogens (OPPPs) in 24 roof-harvested rainwater (RHRW) tanks repeatedly sampled over six monthly sampling events (n = 144) from August 2015 to March 2016 was conducted using quantitative qPCR. Fecal indicator bacteria (FIB) Escherichia coli (E. coli) and Enterococcus spp. were enumerated using culture-based methods. All tank water samples over the six events were positive for at least one OPPP (Legionella spp., Legionella pneumophila, Mycobacterium avium, Mycobacterium intracellulare, Pseudmonas aeruginosa, or Acanthamoeba spp...
January 2, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28039877/noninvasive-assessment-of-liver-fibrosis-stage-using-ultrasound-based-shear-wave-velocity-measurements-and-serum-algorithms-in-patients-with-viral-hepatitis-b-a-retrospective-cohort-study
#18
Jianxue Liu, Junzhi Zhao, Yaoren Zhang, Yonghao Ji, Shumei Lin, Guoliang Dun, Sujuan Guo
OBJECTIVES: Liver biopsy remains the reference standard for the assessment of liver fibrosis, but this procedure is invasive and can lead to complications. Thus, studies to determine the optimal noninvasive test are warranted. This study compared several noninvasive tests and their combinations for evaluating liver fibrosis stages in patients with chronic hepatitis B. METHODS: The shear wave velocity (SWV) and laboratory indicators were collected from 174 patients with chronic hepatitis B...
December 31, 2016: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28035496/the-role-of-current-and-historical-alcohol-use-in-hepatic-fibrosis-among-hiv-infected-individuals
#19
H Nina Kim, Heidi M Crane, Carla V Rodriguez, Stephen Van Rompaey, Kenneth H Mayer, Katerina Christopoulos, Sonia Napravnik, Geetanjali Chander, Heidi Hutton, Mary E McCaul, Edward R Cachay, Michael J Mugavero, Richard Moore, Elvin Geng, Joseph J Eron, Michael S Saag, Joseph O Merrill, Mari M Kitahata
We examined risk factors for advanced hepatic fibrosis [fibrosis-4 (FIB)-4 >3.25] including both current alcohol use and a diagnosis of alcohol use disorder among HIV-infected patients. Of the 12,849 patients in our study, 2133 (17%) reported current hazardous drinking by AUDIT-C, 2321 (18%) had a diagnosis of alcohol use disorder, 2376 (18%) were co-infected with chronic hepatitis C virus (HCV); 596 (5%) had high FIB-4 scores >3.25 as did 364 (15%) of HIV/HCV coinfected patients. In multivariable analysis, HCV (adjusted odds ratio (aOR) 6...
December 29, 2016: AIDS and Behavior
https://www.readbyqxmd.com/read/28024457/haemorrhagic-enteritis-of-turkeys-current-knowledge
#20
Kuldeep Dhama, Vasudevan Gowthaman, Kumaragurubaran Karthik, Ruchi Tiwari, Swati Sachan, M Asok Kumar, M Palanivelu, Yashpal Singh Malik, Raj Kumar Singh, Muhammad Munir
Haemorrhagic enteritis virus (HEV), an adenovirus associated with acute hemorrhagic gastro-intestinal disease of 6-11 weeks old turkeys predominantly hampers both humoral and cellular immunity. Affected birds are more prone to secondary complications (like colibacillosis and clostridiosis) and failure to mount an effective vaccine-induced immune response. HEV belongs to the new genus Siadenovirus. Feco-oral transmission is the main route of entry of the virus and it mainly colonizes bursa, intestine and spleen...
December 27, 2016: Veterinary Quarterly
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