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https://www.readbyqxmd.com/read/28510705/crystal-structure-of-octocoral-lectin-sll-2-complexed-with-forssman-antigen-tetrasaccharide
#1
Akiko Kita, Mitsuru Jimbo, Ryuichi Sakai, Yukio Morimoto, Ryota Takeuchi, Hiroshi Tanaka, Takashi Takahashi, Kunio Miki
A symbiosis-related lectin, SLL-2, from the octocoral Sinularia lochmodes, distributes densely on the cell surface of microalgae, Symbiodinium sp., an endosymbiotic dinoflagellate of the coral, and is also shown to be a chemical cue that transforms dinoflagellates into a non-motile (coccoid) symbiotic state. SLL-2 binds to the sugar chain of the molecule similar to Forssman antigen pentasaccharide (GalNAcα1-3GalNAcβ1-3 Galα1-4 Galβ1-4Glc) on the surface of microalgae with high affinity. Here we report the crystal structure of the complex between SLL-2 and Forssman antigen tetrasaccharide (GalNAcα1-3GalNAcβ1-3 Galα1-4 Galβ) at 3...
May 16, 2017: Glycobiology
https://www.readbyqxmd.com/read/28499343/knee-loading-deficits-during-dynamic-tasks-in-individuals-following-acl-reconstruction
#2
Kristamarie A Pratt, Susan M Sigward
Study Design Controlled laboratory study, cross-sectional. Background Well documented deficits in sagittal plane knee loading, during dynamic tasks indicate individuals limit the magnitude of knee loading following anterior cruciate ligament reconstruction (ACLR). It is unknown how these individuals modulate the speed of knee flexion during loading, which is particularly important as they progress to running during rehabilitation. Objective To investigate how individuals following anterior cruciate ligament reconstruction perform dynamic knee loading tasks compared to healthy controls...
May 12, 2017: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/28473407/clinico-pathological-features-and-outcomes-of-progression-of-cll-on-the-bcl2-inhibitor-venetoclax
#3
Mary Ann Anderson, Constantine Tam, Thomas E Lew, Surender Juneja, Manu Juneja, David Westerman, Meaghan Wall, Stephen Lade, Alexandra Gorelik, David C S Huang, John F Seymour, Andrew W Roberts
The BCL2 inhibitor venetoclax achieves responses in ~79% of patients with relapsed or refractory chronic lymphocytic leukemia/small lymphocytic lymphoma (RR-CLL/SLL), irrespective of risk factors associated with poor response to chemo-immunotherapy. A limitation of this targeted therapy is progressive disease (PD) in some patients. To define the risk factors for progression, the clinico-pathological features of PD and the outcomes for patients after venetoclax failure, we analyzed 67 heavily pre-treated patients on three early phase clinical trials...
May 4, 2017: Blood
https://www.readbyqxmd.com/read/28437781/the-reliability-and-criterion-validity-of-2d-video-assessment-of-single-leg-squat-and-hop-landing
#4
Lee Herrington, Faisal Alenezi, Msaad Alzhrani, Hasan Alrayani, Richard Jones
The objective was to assess the intra-tester, within and between day reliability of measurement of hip adduction (HADD) and frontal plane projection angles (FPPA) during single leg squat (SLS) and single leg landing (SLL) using 2D video and the validity of these measurements against those found during 3D motion capture. 15 healthy subjects had their SLS and SLL assessed using 3D motion capture and video analysis. Inter-tester reliability for both SLS and SLL when measuring FPPA and HADD show excellent correlations (ICC2,1 0...
June 2017: Journal of Electromyography and Kinesiology
https://www.readbyqxmd.com/read/28425443/hybridization-of-strength-pareto-multiobjective-optimization-with-modified-cuckoo-search-algorithm-for-rectangular-array
#5
Khairul Najmy Abdul Rani, Mohamedfareq Abdulmalek, Hasliza A Rahim, Neoh Siew Chin, Alawiyah Abd Wahab
This research proposes the various versions of modified cuckoo search (MCS) metaheuristic algorithm deploying the strength Pareto evolutionary algorithm (SPEA) multiobjective (MO) optimization technique in rectangular array geometry synthesis. Precisely, the MCS algorithm is proposed by incorporating the Roulette wheel selection operator to choose the initial host nests (individuals) that give better results, adaptive inertia weight to control the positions exploration of the potential best host nests (solutions), and dynamic discovery rate to manage the fraction probability of finding the best host nests in 3-dimensional search space...
April 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28414935/cdna-cloning-molecular-modeling-and-docking-calculations-of-l-type-lectins-from-swartzia-simplex-var-grandiflora-leguminosae-papilionoideae-a-member-of-the-tribe-swartzieae
#6
Paulo A C Maranhão, Claudener S Teixeira, Bruno L Sousa, Ito L Barroso-Neto, José E Monteiro-Júnior, Andreia V Fernandes, Marcio V Ramos, Ilka M Vasconcelos, José F C Gonçalves, Bruno A M Rocha, Valder N Freire, Thalles B Grangeiro
The genus Swartzia is a member of the tribe Swartzieae, whose genera constitute the living descendants of one of the early branches of the papilionoid legumes. Legume lectins comprise one of the main families of structurally and evolutionarily related carbohydrate-binding proteins of plant origin. However, these proteins have been poorly investigated in Swartzia and to date, only the lectin from S. laevicarpa seeds (SLL) has been purified. Moreover, no sequence information is known from lectins of any member of the tribe Swartzieae...
July 2017: Phytochemistry
https://www.readbyqxmd.com/read/28408436/cyclin-d1-overexpression-in-proliferation-centres-of-small-lymphocytic-lymphoma-chronic-lymphocytic-leukaemia
#7
Larissa Sena Teixeira Mendes, Natalie Peters, Ayoma D Attygalle, Andrew Wotherspoon
The recent publication reviewing the updated WHO classification commented on the presence of cyclin D1-positive cells in the proliferation centres (PC) of small lymphocytic lymphoma/chronic lymphocytic leukaemia (SLL/CLL). The figure quoted was 30%, which appeared higher than our experience. To assess cyclin D1 expression in PC of SLL/CLL cases, we performed a review of SLL/CLL cases diagnosed at the Royal Marsden Hospital between 1996 and 2009. Of 105 SLL/CLL cases, 16.2% showed expression of cyclin D1 in PC with none carrying the translocation t(11;14)(q13;q32)...
April 13, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28407516/quantitative-mir-analysis-in-chronic-lymphocytic-leukaemia-small-lymphocytic-lymphoma-proliferation-centres-are-characterized-by-high-mir-92a-and-mir-155-and-low-mir-150-expression
#8
Kinga Szurián, Irén Csala, Violetta Piurkó, Linda Deák, András Matolcsy, Lilla Reiniger
Proliferation centres (PCs) are histological hallmarks of lymph nodes in chronic lymphocytic leukaemia/small lymphocytic lymphoma (CLL/SLL). Chromosomal abnormalities have already been described to accumulate preferably in the PCs as opposed to the intervening small cell areas. To further characterize the pathogenic role of PCs, the expression levels of 17 selected miRs known to be involved in the development of CLL/SLL were compared in the PCs and the intervening small cell areas in lymph nodes of 15 patients with CLL/SLL...
April 4, 2017: Leukemia Research
https://www.readbyqxmd.com/read/28373948/arthroscopic-scapholunate-capsuloligamentous-repair-suture-with-dorsal-capsular-reinforcement-for-scapholunate-ligament-lesion
#9
Vicente Carratalá, Francisco J Lucas, Ignacio Miranda, Eduardo Sánchez Alepuz, Christian González Jofré
Scapholunate ligament (SLL) injury is the most frequent injury of the intrinsic carpal ligaments. The dorsal part of the SLL is the most important part for the stability of the scapholunate joint, and tears of this part and at least one of its secondary capsular attachments cause scapholunate dissociation. The arthroscopic technique most frequently used for acute injuries is reduction and fixation with Kirschner wires, and techniques that involve a primary repair of the injured ligament are performed by open surgery with efficient results...
February 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/28373262/impact-of-ibrutinib-dose-adherence-on-therapeutic-efficacy-in-patients-with-previously-treated-cll-sll
#10
Paul M Barr, Jennifer R Brown, Peter Hillmen, Susan O'Brien, Jacqueline C Barrientos, Nishitha M Reddy, Steven Coutre, Stephen P Mulligan, Ulrich Jaeger, Richard R Furman, Florence Cymbalista, Marco Montillo, Claire Dearden, Tadeusz Robak, Carol Moreno, John M Pagel, Jan A Burger, Samuel Suzuki, Juthamas Sukbuntherng, George Cole, Danelle F James, John C Byrd
Ibrutinib, an oral inhibitor of Bruton's tyrosine kinase (BTK), at a once-daily dose of 420 mg achieved BTK active-site occupancy in patients with CLL that was maintained at 24 hours. It is unknown if intermittent interruption of ibrutinib therapy contributes to altered clinical outcomes. We therefore evaluated the effect of ibrutinib dose adherence on patient outcomes in the phase 3 RESONATE(TM) trial. The overall mean dose intensity (DI) was 95% with median treatment duration of ~9 months. Pharmacokinetic assessment of ibrutinib exposure at 420 mg dose suggested similar exposure regardless of patient weight or age...
April 3, 2017: Blood
https://www.readbyqxmd.com/read/28364339/characteristics-of-orbital-lymphoma-a-clinicopathological-study-of-26-cases
#11
Daniel Briscoe, Christine Safieh, Yokrat Ton, Hava Shapiro, Ehud I Assia, Dvora Kidron
OBJECTIVE: Evaluation of the medical data of patients with orbital and adnexal lymphoma. DESIGN: Cohort study of all cases diagnosed with orbital or adnexal lymphoma at Meir Medical Center between 1993 and 2007. PARTICIPANTS: Twenty-six patients, with intraorbital or subconjunctival masses with orbital involvement, were examined and followed up between 1 and 8 years. MATERIALS AND METHODS: Examined data included: clinical presentation, age, gender, imaging, tumor location, surgical management, and pathological diagnosis...
March 31, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28342031/ibrutinib-in-cll-a-focus-on-adverse-events-resistance-and-novel-approaches-beyond-ibrutinib
#12
REVIEW
Varinder Kaur, Arjun Swami
Bruton's tyrosine kinase (BTK), a mediator in B cell receptor signaling has been successfully exploited as a therapeutic target in treatment of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL). Ibrutinib is a BTK inhibitor that has shown excellent efficacy in treatment-naïve, heavily pre-treated, and high-risk CLL/SLL. With remarkable efficacy, good oral bioavailability, and modest adverse events profile, ibrutinib use is likely to continue to increase. As data with ibrutinib use in CLL matures, concerns regarding adverse events and drug resistance have emerged...
March 24, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/28340568/chronic-lymphocytic-leukemia-skin-infiltration-mimicking-an-icd-pocket-infection-a-case-report
#13
M Snorek, A Bulava, I Vonke
BACKGROUND: We are presenting a case report on an unreported and unusual cutaneous manifestation of chronic lymphocytic leukemia in a patient with an implantable cardioverter-defibrillator (ICD). CASE PRESENTATION: A 65-year-old man with a history of chronic lymphocytic leukemia (CLL), previously treated with chlorambucil, was referred in October 2013 for extraction of a single chamber ICD due to a suspected device-related infection in the pulse generator area (left-hand side of Fig...
March 24, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28338388/preferred-hip-strategy-during-landing-reduces-knee-abduction-moment-in-collegiate-female-soccer-players
#14
Anh-Dung Nguyen, Jeffrey B Taylor, Taylor G Wimbish, Jennifer L Keith, Kevin R Ford
CONTEXT: Hip focused interventions are aimed to decrease frontal plane knee loading related to anterior cruciate ligament (ACL) injuries. Whether a preferred hip landing strategy decreases frontal plane knee loading is unknown. OBJECTIVE: To determine if a preferred hip landing strategy during a drop vertical jump (DVJ) is utilized during a single leg landing (SLL) task and whether differences in frontal plane knee loading are consistent between a DVJ and a SLL task...
March 24, 2017: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/28335415/time-modulated-arrays-from-their-origin-to-their-utilization-in-wireless-communication-systems
#15
REVIEW
Roberto Maneiro-Catoira, Julio Brégains, José A García-Naya, Luis Castedo
Time-modulated arrays (TMAs) are electromagnetic systems whose radiated power pattern is controlled by the application of variable-width periodical pulses to the individual elements. The nonlinear nature of the array operation causes the appearance of radiation patterns at the harmonic frequencies of such periodic pulses. The technique can be used for improving the side-lobe level (SLL) topology of the radiation pattern at the central frequency and/or to profitably exploit the harmonic patterns in order to supply smart antenna capabilities...
March 14, 2017: Sensors
https://www.readbyqxmd.com/read/28283083/a-novel-model-to-assess-lamellar-signaling-relevant-to-preferential-weight-bearing-in-the-horse
#16
A K Gardner, A W van Eps, M R Watts, T A Burns, J K Belknap
Supporting limb laminitis (SLL) is a devastating sequela to severe unilateral lameness in equine patients. The manifestation of SLL, which usually only affects one limb, is unpredictable and the etiology is unknown. A novel, non-painful preferential weight bearing model designed to mimic the effects of severe unilateral forelimb lameness was developed to assess lamellar signaling events in the supporting limb (SL). A custom v-shaped insert was attached to the shoe of one forelimb to prevent normal weight bearing and redistribute weight onto the SL...
March 2017: Veterinary Journal
https://www.readbyqxmd.com/read/28275031/nccn-guidelines-insights-chronic-lymphocytic-leukemia-small-lymphocytic-leukemia-version-1-2017
#17
William G Wierda, Andrew D Zelenetz, Leo I Gordon, Jeremy S Abramson, Ranjana H Advani, C Babis Andreadis, Nancy Bartlett, John C Byrd, Paolo Caimi, Luis E Fayad, Richard I Fisher, Martha J Glenn, Thomas M Habermann, Nancy Lee Harris, Francisco Hernandez-Ilizaliturri, Richard T Hoppe, Steven M Horwitz, Mark S Kaminski, Christopher R Kelsey, Youn H Kim, Susan Krivacic, Ann S LaCasce, Michael G Martin, Auayporn Nademanee, Pierluigi Porcu, Oliver Press, Rachel Rabinovitch, Nishitha Reddy, Erin Reid, Kenneth Roberts, Ayman A Saad, Erin D Snyder, Lubomir Sokol, Lode J Swinnen, Julie M Vose, Joachim Yahalom, Mary A Dwyer, Hema Sundar
Chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL) are different manifestations of the same disease and managed in much the same way. The advent of novel CD20 monoclonal antibodies led to the development of effective chemoimmunotherapy regimens. More recently, small molecule inhibitors targeting kinases involved in a number of critical signaling pathways and a small molecule inhibitor of the BCL-2 family of proteins have demonstrated activity for the treatment of patients with CLL/SLL. These NCCN Guidelines Insights highlight important updates to the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for CLL/SLL for the treatment of patients with newly diagnosed or relapsed/refractory CLL/SLL...
March 2017: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/28252419/a-regularization-approach-for-instance-based-superset-label-learning
#18
Chen Gong, Tongliang Liu, Yuanyan Tang, Jian Yang, Jie Yang, Dacheng Tao
Different from the traditional supervised learning in which each training example has only one explicit label, superset label learning (SLL) refers to the problem that a training example can be associated with a set of candidate labels, and only one of them is correct. Existing SLL methods are either regularization-based or instance-based, and the latter of which has achieved state-of-the-art performance. This is because the latest instance-based methods contain an explicit disambiguation operation that accurately picks up the groundtruth label of each training example from its ambiguous candidate labels...
February 24, 2017: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/28203174/richter-s-syndrome-with-hypercalcemia-induced-by-tumor-associated-production-of-parathyroid-hormone-related-peptide
#19
Naoki Watanabe, Hajime Yasuda, Soji Morishita, Yasuo Aota, Junichi Tomomatsu, Masaru Tanaka, Akimichi Ohsaka, Norio Komatsu
Humoral hypercalcemia due to parathyroid hormone-related peptide (PTHrP) elevation is a well-known complication of various malignancies, but the situation is rare concerning hematological malignancies except for adult T-cell leukemia/lymphoma. We report a case of Richter's syndrome with humoral hypercalcemia, and demonstrate by reverse transcription polymerase chain reaction (RT-PCR) that peripheral blood PTHrP levels were 2,500-fold higher compared to healthy controls. PTHrP production by tumor cells in chronic lymphocytic leukemia (CLL) and Richter's syndrome has been previously demonstrated by nonquantitative methods such as immunohistochemistry and northern blot analysis, but this is the first report using the RT-PCR method...
January 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/28196821/small-lymphocytic-lymphoma-with-reed-sternberg-cells-a-diagnostic-dilemma
#20
S Pervez, B Abro, H Shahbaz
Reed Sternberg (RS) cells in the setting of small lymphocytic lymphoma (SLL) can complicate the histopathological diagnosis. We report a case of a man aged 54 years who presented with cervical lymphadenopathy. Resection of the lymph node was performed and sent for histopathological evaluation to a local laboratory. A diagnosis of SLL with Classic Hodgkin's lymphoma (CHL) was made. The medical oncologist who encountered this diagnosis for the first time sent the biopsy blocks to our laboratory for a second opinion...
February 14, 2017: BMJ Case Reports
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