Yanli Gu, Liting Lv, Jiajia Jin, Xin Hua, Qiuli Xu, RanPu Wu, Suhua Zhu, Xin Liu, Tangfeng Lv, Yong Song, Fang Zhang
The pathogenesis of acute lung injury is not fully understood. Stimulator of interferon genes (STING) and ferroptosis have been implicated in various pathological and physiological processes, including acute lung injury (ALI). However, the relationship between STING and ferroptosis in lipopolysaccharide (LPS)-induced ALI is unclear. We found that LPS stimulation activated STING and ferroptosis. Furthermore, STING knockout and ferroptosis inhibitor alleviated lung inflammation and epithelial cell damage. Also, STING knockout reduced inflammation injury and ferroptosis...
April 17, 2024: Experimental Cell Research