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https://www.readbyqxmd.com/read/27905585/influence-of-%C3%AF-conjugation-structural-changes-on-intramolecular-charge-transfer-and-photoinduced-electron-transfer-in-donor-%C3%AF-acceptor-dyads
#1
So-Yoen Kim, Yang-Jin Cho, Ah-Rang Lee, Ho-Jin Son, Won-Sik Han, Dae Won Cho, Sang Ook Kang
The influence of π-conjugation structural changes on photoinduced electron transfer (PET) and intramolecular charge transfer (ICT) processes in π-conjugated donor (D)-acceptor (A) dyads (D-π-A) was investigated. Three types of D-π-A dyads were prepared through the modification of the structure of their π-conjugated linker, including D-π-A (1) and D-πtw-A (2) having a twisted π-conjugation, and D-π-Si-π-A (3) with a π-conjugation severed by a Si-atom. In these dyads, carbazole (Cz) and oxadiazole (Oz) moieties act as an electron donor and acceptor, respectively...
December 1, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27905203/efficacy-and-toxicity-of-the-combination-chemotherapy-of-thalidomide-alkylating-agent-and-steroid-for-relapsed-refractory-myeloma-patients-a-report-from-the-korean-multiple-myeloma-working-party-kmmwp-retrospective-study
#2
Jihyun Kwon, Chang-Ki Min, Kihyun Kim, Jae-Joon Han, Joon Ho Moon, Hye Jin Kang, Hyeon-Seok Eom, Min Kyoung Kim, Hyo Jung Kim, Dok Hyun Yoon, Jeong-Ok Lee, Won Sik Lee, Jae Hoon Lee, Je-Jung Lee, Yoon-Seok Choi, Sung Hyun Kim, Sung-Soo Yoon
We analyzed the treatment responses, toxicities, and survival outcomes of patients with relapsed or refractory multiple myeloma who received daily thalidomide, cyclophosphamide, and dexamethasone (CTD) or daily thalidomide, melphalan, and prednisolone (MTP) at 17 medical centers in Korea. Three-hundred and seventy-six patients were enrolled. The combined chemotherapy of thalidomide, corticosteroid, and an alkylating agent (TAS) was second-line chemotherapy in 142 (37.8%) patients, and third-line chemotherapy in 135 (35...
December 1, 2016: Cancer Medicine
https://www.readbyqxmd.com/read/27904663/t-type-calcium-channel-blocker-attenuates-unilateral-ureteral-obstruction-induced-renal-interstitial-fibrosis-by-activating-the-nrf2-antioxidant-pathway
#3
Sungjin Chung, Soojeong Kim, Minyoung Kim, Eun Sil Koh, Hye Eun Yoon, Ho-Shik Kim, Cheol Whee Park, Yoon Sik Chang, Seok Joon Shin
Besides its effect on high blood pressure, T-type calcium channel blocker is renoprotective in experimental models of renal fibrosis. However, the exact mechanism of T-type calcium channel blocker on tubulointerstitial fibrosis is unclear. We investigated whether the renoprotective effect of T-type calcium channel blocker is associated with modulation of the signaling of oxidative stress-induced renal fibrosis. Treatment with a non-hypotensive dose of efonidipine, a T-type calcium channel blocker, or nifedipine, an L-type channel blocker, was initiated one day before unilateral ureteral obstruction (UUO) in C57BL6/J mice, and was continued until 3 and 7 days after UUO...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27901621/perfluorooctanoic-acid-induces-mitochondrial-dysfunction-in-mc3t3-e1-osteoblast-cells
#4
Eun Mi Choi, Kwang Sik Suh, Sang Youl Rhee, Seungjoon Oh, Jeong-Taek Woo, Sung Woon Kim, Young Seol Kim, Youngmi Kim Pak, Suk Chon
Perfluorooctanoic acid (PFOA), a stable organic perfluorinated compound, is an emerging persistent organic pollutant, found widely in human and wildlife populations. Recent evidence suggests that exposure to environmental toxicants can be associated with higher risks of osteoporosis and fractures. We studied the cellular toxicology of PFOA in MC3T3-E1osteoblast cells. To examine the effect of PFOA, we measured cell viability, reactive oxygen species (ROS), mitochondrial superoxide, and mitochondrial parameters including adenosine triphosphate (ATP) level, mitochondrial membrane potential (MMP), cardiolipin content, and cytochrome c release in MC3T3-E1 cells...
November 30, 2016: Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering
https://www.readbyqxmd.com/read/27901502/first-report-of-perkinsus-honshuensis-in-the-variegated-carpet-shell-clam-ruditapes-variegatus-in-korea
#5
Hyun-Sil Kang, Hyun-Sung Yang, Kimberly S Reece, Hyun-Ki Hong, Kyung-Il Park, Kwang-Sik Choi
The recent discovery of Perkinsus honshuensis, a new Perkinsus species infecting Manila clams Ruditapes philippinarum (Sowerby, 1852), in Japan, suggested that, based on proximity, P. honshuensis could also be in Korean waters, where to date, P. olseni was believed to be the only Perkinsus species present. Perkinsus sp. infections consistently occurred among Ruditapes variegatus clams on a pebble beach on Jeju Island, off the south coast of Korea. The typical 'signet ring' morphology of the parasite was observed in the connective tissue of the digestive gland, and infection intensity was comparatively low (3...
November 22, 2016: Diseases of Aquatic Organisms
https://www.readbyqxmd.com/read/27901492/genomic-and-transcriptomic-characterization-of-skull-base-chordoma
#6
Jason K Sa, In-Hee Lee, Sang Duk Hong, Doo-Sik Kong, Do-Hyun Nam
Skull base chordoma is a primary rare malignant bone-origin tumor showing relatively slow growth pattern and locally destructive lesions, which can only be characterized by histologic components. There is no available prognostic or therapeutic biomarker to predict clinical outcome or treatment response and the molecular mechanisms underlying chordoma development still remain unexplored. Therefore, we sought out to identify novel somatic variations that are associated with chordoma progression and potentially employed as therapeutic targets...
November 25, 2016: Oncotarget
https://www.readbyqxmd.com/read/27901267/binge-alcohol-intake-after-hypergravity-stress-sustainably-decreases-ampk-and-transcription-factors-necessary-for-hepatocyte-survival
#7
Sang Gil Lee, Hong Min Wu, Chan Gyu Lee, Choong Sik Oh, So Won Chung, Sang Geon Kim
BACKGROUND: Binge alcohol consumption elicits mitochondrial dysfunction in hepatocytes. An understanding of the effect of ethanol (EtOH) exposure after hypergravity stress on liver function may assist in the implementation of pathophysiological countermeasures for aerospace missions. This study investigated whether a combination of hypergravity stress and binge alcohol intake has a detrimental effect on AMP-activated protein kinase (AMPK) and other molecules necessary for hepatocyte survival...
November 30, 2016: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/27899751/air-pollution-is-associated-with-ischemic-stroke-via-cardiogenic-embolism
#8
Jong-Won Chung, Oh Young Bang, Kangmo Ahn, Sang-Soon Park, Tai Hwan Park, Jae Guk Kim, Youngchai Ko, SooJoo Lee, Kyung Bok Lee, Jun Lee, Kyusik Kang, Jong-Moo Park, Yong-Jin Cho, Keun-Sik Hong, Hyun-Wook Nah, Dae-Hyun Kim, Jae-Kwan Cha, Wi-Sun Ryu, Dong-Eog Kim, Joon-Tae Kim, Jay Chol Choi, Mi-Sun Oh, Kyung-Ho Yu, Byung-Chul Lee, Ji Sung Lee, Juneyoung Lee, Hong-Kyun Park, Beom Joon Kim, Moon-Ku Han, Hee-Joon Bae
BACKGROUND AND PURPOSE: The aim of the study was to assessed the impact of short-term exposure to air pollution on ischemic stroke subtype, while focusing on stroke caused via cardioembolism. METHODS: From a nationwide, multicenter, prospective, stroke registry database, 13 535 patients with acute ischemic stroke hospitalized to 12 participating centers were enrolled in this study. Data on the hourly concentrations of particulate matter <10 μm, nitrogen dioxide (NO2), sulfur dioxide (SO2), ozone (O3), and carbon monoxide (CO) were collected from 181 nationwide air pollution surveillance stations...
November 29, 2016: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/27898712/modified-dynamic-decode-and-forward-relaying-protocol-for-type-ii-relay-in-lte-advanced-and-beyond
#9
Sung Sik Nam, Mohamed-Slim Alouini, Seyeong Choi
In this paper, we propose a modified dynamic decode-and-forward (MoDDF) relaying protocol to meet the critical requirements for user equipment (UE) relays in next-generation cellular systems (e.g., LTE-Advanced and beyond). The proposed MoDDF realizes the fast jump-in relaying and the sequential decoding with an application of random codeset to encoding and re-encoding process at the source and the multiple UE relays, respectively. A subframe-by-subframe decoding based on the accumulated (or buffered) messages is employed to achieve energy, information, or mixed combining...
2016: PloS One
https://www.readbyqxmd.com/read/27896507/levonorgestrel-releasing-intrauterine-systems-versus-oral-cyclic-medroxyprogesterone-acetate-in-endometrial-hyperplasia-therapy-a-meta-analysis
#10
Jin-Sung Yuk, Jae Yen Song, Jung Hun Lee, Won I Park, Hyeong Sik Ahn, Hyun Jung Kim
BACKGROUND: This study aimed to compare the levonorgestrel-releasing intrauterine system (LNG-IUS) with oral cyclic medroxyprogesterone acetate (MPA) in endometrial hyperplasia therapy using randomized controlled trials (RCTs). METHODS: The study searched MEDLINE, EMBASE, CENTRAL, and other databases. All regression outcomes were calculated for dichotomous outcomes in terms of relative risk (RR) and 95% confidence intervals (CIs) using a Mantel-Haenszel random effects model...
November 28, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27896211/comparison-of-postoperative-changes-in-the-distal-and-proximal-segments-between-conventional-and-sliding-mini-plate-fixation-following-mandibular-setback
#11
Seong-Sik Kim, Kyoung-Ho Kwak, Ching-Chang Ko, Soo-Byung Park, Woo-Sung Son, Yong-Il Kim
OBJECTIVE: The purpose of the present study was to evaluate the postoperative three-dimensional (3D) changes in the proximal segments after mandibular setback sagittal split ramus osteotomy and to compare the changes between the conventional mini-plate fixation and semi-rigid sliding plate fixation. METHODS: Cone-beam computed tomography (CBCT) images were used to evaluate the postoperative 3D changes in the proximal segments during the healing process. CBCT images were superimposed using the symphysis and the lower anterior mandible as references...
November 2016: Korean Journal of Orthodontics
https://www.readbyqxmd.com/read/27896201/primary-necrotizing-fasciitis-of-the-breast-in-an-untreated-patient-with-diabetes
#12
Jeong Hwan Lee, Yun Sub Lim, Nam Gyun Kim, Kyung Suk Lee, Jun Sik Kim
No abstract text is available yet for this article.
November 2016: Archives of Plastic Surgery
https://www.readbyqxmd.com/read/27896200/full-thickness-burn-on-the-finger-due-to-pulse-oximetry-during-magnetic-resonance-imaging-in-a-conscious-patient
#13
Seung Je Sung, Yong Sik Park, Jae Young Cho
No abstract text is available yet for this article.
November 2016: Archives of Plastic Surgery
https://www.readbyqxmd.com/read/27896191/comparison-of-the-effectiveness-of-ablative-and-non-ablative-fractional-laser-treatments-for-early-stage-thyroidectomy-scars
#14
Jin-Uk Jang, Soo-Young Kim, Eul-Sik Yoon, Woo-Kyung Kim, Seung-Ha Park, Byung-Il Lee, Deok-Woo Kim
BACKGROUND: Open thyroidectomy is conventionally performed at the anterior side of neck, which is a body part with a comparatively great degree of open exposure; due to this, postoperative scarring may cause distress in patients. We aimed to compare the effects of ablative and nonablative fractional laser treatments on thyroidectomy scars. We examined medical records in a retrospective manner and analyzed scars based on their digital images by using the modified Manchester Scar Scale (mMSS)...
November 2016: Archives of Plastic Surgery
https://www.readbyqxmd.com/read/27896180/correction-of-congenital-auricular-deformities-using-the-ear-molding-technique
#15
Taeyong Woo, Young Seok Kim, Tai Suk Roh, Dae Hyun Lew, In Sik Yun
BACKGROUND: Studies of the ear-molding technique have emphasized the importance of initiating molding early to achieve the best results. In the present study, we describe the immediate effects and long-term outcomes of this technique, focusing on children who were older than the ideal age of treatment initiation. METHODS: Patients who visited our institution from July 2014 to November 2015 were included. Medical charts were reviewed to collect data on demographics, the duration of treatment, the types of deformities, and the manner of recognition of the deformity and referral to our institution...
November 2016: Archives of Plastic Surgery
https://www.readbyqxmd.com/read/27895881/morphologic-evaluation-of-ductus-diverticulum-using-multi-detector-computed-tomography-comparison-with-traumatic-pseudoaneurysm-of-the-aortic-isthmus
#16
Jun Hyung Ann, Eun Young Kim, Yu Mi Jeong, Jeong Ho Kim, Hyung Sik Kim, Hye-Young Choi
OBJECTIVES: To evaluate morphologic variations at the aortic isthmus with particular attention to ductus diverticulum, a mimicker of traumatic pseudoaneurysm, and to describe differences using Computed Tomography (CT) images. PATIENTS AND METHODS: From December 2013 to December 2014, patients who underwent a chest CT examination after blunt trauma at our emergency department were included. Aortic isthmus morphologies were evaluated using multiplanar reconstruction (MPR) and maximum intensity projection (MIP) images as follows...
October 2016: Iranian Journal of Radiology: a Quarterly Journal Published By the Iranian Radiological Society
https://www.readbyqxmd.com/read/27894808/protective-effect-of-betulinic-acid-on-early-atherosclerosis-in-diabetic-apolipoprotein-e-gene-knockout-mice
#17
Jung Joo Yoon, Yun Jung Lee, Byung Hyuk Han, Eun Sik Choi, Min Chul Kho, Ji Hun Park, You Mee Ahn, Hye Yoom Kim, Dae Gill Kang, Ho Sub Lee
Atherosclerosis, a chronic and progressive disease, is a leading cause of endothelial dysfunction, diabetes mellitus, hypertension, and hypercholesterolemia. Betulinic acid (BA), a pentacyclic triterpene, has been reported to have a variety of biological effects, including anti-inflammatory and immunomodulatory properties. This study was designed to determine whether BA could prevent atherosclerosis in diabetic apolipoprotein-E gene knockout (ApoE KO) mice. The mice were treated with BA for 12 weeks to examine its beneficial effects on atherosclerosis in ApoE KO mice...
November 25, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/27891245/genetic-diversity-of-halla-horses-using-microsatellite-markers
#18
Joo-Hee Seo, Kyung-Do Park, Hak-Kyo Lee, Hong-Sik Kong
BACKGROUND: Currently about 26,000 horses are breeding in Korea and 57.2% (14,776 horses) of them are breeding in Jeju island. According to the statistics published in 2010, the horses breeding in Jeju island are subdivided into Jeju horse (6.1%), Thoroughbred (18.8%) and Halla horse (75.1%). Halla horses are defined as a crossbreed between Jeju and Thoroughbred horses and are used for horse racing, horse riding and horse meat production. However, little research has been conducted on Halla horses because of the perception of crossbreed and people's weighted interest toward Jeju horses...
2016: Journal of Animal Science and Technology
https://www.readbyqxmd.com/read/27890759/transforaminal-percutaneous-endoscopic-lumbar-discectomy-with-percutaneous-epidural-neuroplasty-in-lumbar-disc-herniation-technical-note
#19
Hyeong-Jin Lee, Jin-Sung Kim, Kyeong-Sik Ryu
OBJECTIVE: Percutaneous endoscopic lumbar discectomy and percutaneous epidural neuroplasty is a commonly used minimally invasive spinal surgery in lumbar disc herniation. But to our knowledge, there is no report about the results of percutaneous endoscopic lumbar discectomy with percutaneous epidural neuroplasty. We did this study to evaluate the effect of percutaneous endoscopic lumbar discectomy with percutaneous epidural neuroplasty in lumbar disc herniation. METHODS: We report the series of cases about technics and results of percutaneous endoscopic lumbar discectomy with percutaneous epidural neuroplasty in lumbar disc herniation...
November 24, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27890717/ecdysone-receptor-ecr-and-ultraspiracle-usp-genes-from-the-cyclopoid-copepod-paracyclopina-nana-identification-and-expression-in-response-to-water-accommodated-fractions-wafs
#20
Jayesh Puthumana, Min-Chul Lee, Jeonghoon Han, Hui-Su Kim, Dae-Sik Hwang, Jae-Seong Lee
Ecdysteroid hormones are pivotal in the development, growth, and molting of arthropods, and the hormone pathway is triggered by binding ecdysteroid to a heterodimer of the two nuclear receptors; ecdysone receptors (EcR) and ultraspiracle (USP). We have characterized EcR and USP genes, and their 5'-untranslated region (5'-UTR) from the copepod Paracyclopina nana, and studied mRNA transcription levels in post-embryonic stages and in response to water accommodated fractions (WAFs) of crude oil. The open reading frames (ORF) of EcR and USP were 1470 and 1287bp that encoded 490 and 429 amino acids with molecular weight of 121...
November 23, 2016: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
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