keyword
MENU ▼
Read by QxMD icon Read
search

SIK

keyword
https://www.readbyqxmd.com/read/28550731/xanthotoxin-suppresses-lps-induced-expression-of-inos-cox-2-tnf-%C3%AE-and-il-6-via-ap-1-nf-%C3%AE%C2%BAb-and-jak-stat-inactivation-in-raw-264-7-macrophages
#1
Seung-Bin Lee, Woo Seok Lee, Ji-Sun Shin, Dae Sik Jang, Kyung Tae Lee
Although xanthotoxin has been reported to possess skin-protective and anti-oxidative properties, its anti-inflammatory capacity has not been studied to date. Therefore, we investigated this role as well as the molecular mechanisms of xanthotoxin in lipopolysaccharide (LPS)-induced RAW 264.7 macrophages. Xanthotoxin inhibited production of nitric oxide (NO), prostaglandin E2 (PGE2), tumor necrosis factor (TNF-α), and interleukin-6 (IL-6) by the LPS-induced macrophages in a concentration-dependent manner. It also suppressed the LPS-induced inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression at the protein levels and iNOS, COX-2, TNF-α, and IL-6 at the mRNA levels...
May 24, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28550601/potential-toxicity-of-trace-elements-and-nanomaterials-to-chinese-cabbage-in-arsenic-and-lead-contaminated-soil-amended-with-biochars
#2
Yasser Mahmoud Awad, Meththika Vithanage, Nabeel Khan Niazi, Muhammad Rizwan, Jörg Rinklebe, Jae E Yang, Yong Sik Ok, Sang Soo Lee
To our knowledge, this is the first report on exploring the interactive effects of various biochars (BCs) and nanomaterials (NMs) on plant growth and bioavailability of trace elements in soil. This study evaluated the bioavailability and toxicity of arsenic (As), lead (Pb), and NMs to cabbage plants. The BCs were produced from rice husk (RB), sewage sludge, and bamboo wood (WB). The BCs at 2.5 and 5% (w w(-1)), NMs for removing As (NMs-As) and heavy metals (NMs-HM) at 3000 mg kg(-1), and multi-walled carbon nanotubes (CNT) at 1000 mg kg(-1) were applied in bioassay and incubation experiments (40 days), along with the unamended soil as the control...
May 26, 2017: Environmental Geochemistry and Health
https://www.readbyqxmd.com/read/28550600/adsorption-antagonism-and-synergy-of-arsenate-v-and-cadmium-ii-onto-fe-modified-rice-straw-biochars
#3
Youchi Zhang, Jiajun Fan, Minglai Fu, Yong Sik Ok, Yanwei Hou, Chao Cai
Arsenic-containing water poses a serious threat to human health. In this study, two types of Fe-modified rice straw biochars [(Fe-impregnated biochar (FeIm char) and pre-modified rice straw biochar (PMRS char)] were prepared, in which three ratios [1, 5, and 10% (w/w)] of Fe modification were evaluated, resulting in six different Fe-modified biochars. Then, a series of adsorption experiments, using single- and binary-metal solutions of As(V) and Cd(II), were conducted to investigate the performances of modified biochars on metal adsorption compared to pristine rice straw biochar (RS char)...
May 26, 2017: Environmental Geochemistry and Health
https://www.readbyqxmd.com/read/28548050/reversible-crystalline-amorphous-phase-transformation-in-si-nanosheets-with-lithi-delithiation
#4
Jeong Min Park, Jae-Hyun Cho, Jung Hoon Ha, Hae-Sik Kim, Sung-Wook Kim, Jaejun Lee, Kyung Yoon Chung, Byung-Won Cho, Heon-Jin Choi
Silicon (Si) has a large theoretical capacity of 4200 mAhg(-1) and has great potential as a high-performance anode material for Li ion batteries (LIBs). Meanwhile, nanostructures can exploit the potential of Si and, accordingly, many zero-dimensional (0D) and one-dimensional (1D) Si nanostructures have been studied. Herein, we report on two-dimensional (2D) Si nanostructures, Si nanosheets (SiNSs), as anodes for LIBs. These 2D Si nanostructures, with a thickness as low 5 nm and widths of several micrometers, show reversible crystalline-amorphous phase transformations with the lithi-/delithiation by the dimensionality of morphology and large surface area...
May 26, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28546521/phase-ii-study-of-induction-chemotherapy-with-docetaxel-capecitabine-and-cisplatin-plus-bevacizumab-for-initially-unresectable-gastric-cancer-with-invasion-of-adjacent-organs-or-paraaortic-lymph-node-metastasis
#5
Jwa Hoon Kim, Sook Ryun Park, Min-Hee Ryu, Baek-Yeol Ryoo, Kyu-Pyo Kim, Beom Su Kim, Moon-Won Yoo, Jeong Hwan Yook, Byung Sik Kim, Jihun Kim, Sun-Ju Byeon, Yoon-Koo Kang
Purpose: To evaluate the efficacy and safety of induction chemotherapy with docetaxel, capecitabine, and cisplatin (DXP) plus bevacizumab (BEV) on initially unresectable locally advanced gastric cancer (LAGC) or paraaortic lymph node (PAN) metastatic gastric cancer (GC). Materials and Methods: Patients with LAGC or unresectable PAN metastatic GC received 6 induction chemotherapy cycles (60 mg/m2 docetaxel intravenously [i.v.] on day 1, 937.5 mg/m2 capecitabine orally twice daily on days 1-14, 60 mg/m2 cisplatin i...
May 24, 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/28545489/cytotoxic-necrotizing-factor-1-cnf1-does-not-promote-e-coli-infection-in-a-murine-model-of-ascending-pyelonephritis
#6
Jason E Michaud, Kwang Sik Kim, William Harty, Matthew Kasprenski, Ming-Hsien Wang
BACKGROUND: Urinary tract infections (UTI) are among the most common and costly infections in both hospitalized and ambulatory patients. Uropathogenic E. coli (UPEC) represent the majority of UTI isolates and are a diverse group of bacteria that utilize a variety of virulence factors to establish infection of the genitourinary tract. The virulence factor cytotoxic necrotizing factor-1 (CNF1) is frequently expressed in clinical UPEC isolates. To date, there have been conflicting reports on the role of CNF1 in the pathogenesis of E...
May 25, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28545323/an-efficient-phosphorus-scavenging-from-aqueous-solution-using-magnesiothermally-modified-bio-calcite
#7
Munir Ahmad, Mahtab Ahmad, Adel R A Usman, Abdullah S Al-Faraj, Yong Sik Ok, Qaiser Hussain, Adel Abduljabbar, Mohammad I Al-Wabel
The excessive discharge of phosphorus (P) from sewage treatment plants and runoff from agricultural fields is causing a rapid contamination of water resources worldwide. Several materials have been evaluated for the removal of excess P from waste supplies, but designing a cost-effective and environmental friendly substrate is essential for the efficient P removal. In this study, bio-calcite (BC) derived from waste hen eggshell was subjected to thermal treatments (CBC). The BC and CBC further modified via magnesiothermal treatments to produced MBC and MCBC, respectively, and evaluated as a novel green sorbent for P removal from aqueous solutions...
May 26, 2017: Environmental Technology
https://www.readbyqxmd.com/read/28545252/cpg-and-non-cpg-methylation-in-epigenetic-gene-regulation-and-brain-function
#8
REVIEW
Hyun Sik Jang, Woo Jung Shin, Jeong Eon Lee, Jeong Tae Do
DNA methylation is a major epigenetic mark with important roles in genetic regulation. Methylated cytosines are found primarily at CpG dinucleotides, but are also found at non-CpG sites (CpA, CpT, and CpC). The general functions of CpG and non-CpG methylation include gene silencing or activation depending on the methylated regions. CpG and non-CpG methylation are found throughout the whole genome, including repetitive sequences, enhancers, promoters, and gene bodies. Interestingly, however, non-CpG methylation is restricted to specific cell types, such as pluripotent stem cells, oocytes, neurons, and glial cells...
May 23, 2017: Genes
https://www.readbyqxmd.com/read/28543366/clinical-characteristics-and-long-term-prognosis-of-elderly-onset-ulcerative-colitis
#9
Eun Mi Song, Ho-Su Lee, Sang Hyoung Park, Gwang Un Kim, Myeong Sook Seo, Sung Wook Hwang, Dong-Hoon Yang, Kyung-Jo Kim, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Byong Duk Ye
BACKGROUND: The aim of this study was to investigate the clinical characteristics and prognosis of patients with elderly-onset ulcerative colitis (EOUC), a new growing subgroup of UC. METHODS: We retrospectively analyzed 3,060 South Korean UC patients diagnosed between 1977 and 2014. The clinical characteristics and prognosis of EOUC, defined as UC in those aged ≥ 60 years at diagnosis, were compared to those of non-elderly-onset UC (NEOUC). RESULTS: Among the 3,060 patients, 226 were diagnosed with EOUC (7...
May 19, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28542556/an-inactivated-hand-foot-and-mouth-disease-vaccine-using-the-enterovirus-71-c4a-strain-isolated-from-a-korean-patient-induces-a-strong-immunogenic-response-in-mice
#10
Hyun Ju In, Heeji Lim, Jung-Ah Lee, Hye Jin Kim, Jin-Won Kim, Ji-Yeon Hyeon, Sang-Gu Yeo, June-Woo Lee, Jung Sik Yoo, Young Ki Choi, Sang-Won Lee
Enterovirus 71 (EV71) is a major causative agent of hand-foot-and-mouth disease (HFMD) frequently occurring in children. HFMD induced by EV71 can cause serious health problems and has been reported worldwide, particularly in the Asia-Pacific region. In this study, we assessed the immunogenicity of a formalin-inactivated HFMD vaccine using an EV71 strain (FI-EV71 C4a) isolated from a Korean patient. The vaccine candidate was evaluated in mice to determine the vaccination doses and vaccine schedules. BALB/c mice were intramuscularly administered 5, 10, or 20 μg FI-EV71 vaccine, followed by a booster 2 weeks later...
2017: PloS One
https://www.readbyqxmd.com/read/28542504/level-of-surgical-experience-is-associated-with-change-in-hip-center-of-rotation-following-cementless-total-hip-arthroplasty-a-radiographic-assessment
#11
Seung-Chan Kim, Young-Wook Lim, Soon-Yong Kwon, Woo-Lam Jo, Sung-Hun Ju, Chan-Joo Park, Choong-Woo Lee, Yong-Sik Kim
OBJECTIVES: After total hip arthroplasty (THA), restoration of hip center of rotation (COR) is essential to ensure stability of the prosthetic hip and longevity of the prosthesis. Our aim was to determine whether, and how, the COR changed postoperatively compared to the native COR following implantation of a cementless acetabular component in anatomical position and to compare the accuracy of cup placement between two surgeons with different levels of surgical experience. MATERIALS AND METHODS: We evaluated 145 patients (145 hips) who underwent unilateral primary THA, who had no distorted acetabulum on the affected hip and a normal contralateral hip...
2017: PloS One
https://www.readbyqxmd.com/read/28542373/comparative-effectiveness-of-oral-antidiabetic-drugs-in-preventing-cardiovascular-mortality-and-morbidity-a-network-meta-analysis
#12
Gyeongsil Lee, Seung-Won Oh, Seung-Sik Hwang, Ji Won Yoon, Sungchan Kang, Hee-Kyung Joh, Hyuktae Kwon, Jeehyun Kim, Danbee Park
In the Guidance for Industry from the Food and Drug Administration in 2008, excess cardiovascular risk should be ruled out in trials of all new antidiabetic drugs; however, relatively few studies have focused on cardiovascular safety with antidiabetic drug use. We aimed to examine mortality and cardiovascular risk using a network meta-analysis. We searched the Medline, Embase, Cochrane, and ClinicalTrials.gov registry databases in March 2016 to identify randomized controlled trials reporting cardiovascular risk with the following oral antidiabetic drugs: metformin, sulfonylureas, thiazolidinedione (TZD), dipeptidyl peptidase-4 (DPP4) inhibitors, and sodium-glucose co-transporter-2 (SGLT2) inhibitors...
2017: PloS One
https://www.readbyqxmd.com/read/28542298/early-anti-tnf-immunomodulator-therapy-is-associated-with-better-long-term-clinical-outcomes-in-asian-patients-with-crohn-s-disease-with-poor-prognostic-factors
#13
Eun Hye Oh, Kyunghwan Oh, Minkyu Han, Hyungil Seo, Kiju Chang, Sun-Ho Lee, Gwang-Un Kim, Eun Mi Song, Myeongsook Seo, Ho-Su Lee, Sung Wook Hwang, Sang Hyoung Park, Dong-Hoon Yang, Kyung-Jo Kim, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Byong Duk Ye
Although early treatment of Crohn's disease (CD) patients with anti-tumor necrosis factor (TNF) agents or immunomodulators (IMs) may improve long-term outcomes, especially those with poor prognostic factors, their effectiveness in Asians remains unclear. In this study, Korean patients with CD naïve to both intestinal surgery and intestinal complications, and with at least two risk factors for progression (diagnosis at age <40 years, systemic corticosteroid treatment <3 months after diagnosis, and perianal fistula at diagnosis) were retrospectively analyzed...
2017: PloS One
https://www.readbyqxmd.com/read/28542030/predictors-of-poor-clinical-outcomes-after-successful-chronic-total-occlusion-intervention-with-drug-eluting-stents
#14
Gwang-Sil Kim, Byeong-Keuk Kim, Dong-Ho Shin, Jung-Sun Kim, Myeong-Ki Hong, Hyeon-Cheol Gwon, Hyo-Soo Kim, Cheol Woong Yu, Hun Sik Park, In-Ho Chae, Seung-Woon Rha, Yangsoo Jang
BACKGROUND: The aim of this study was to identify the prognostic predictors for the worse clinical outcomes after a successful chronic total occlusion (CTO) intervention with drug-eluting stents. PATIENTS AND RESULTS: A total of 2334 patients in the multicenter Korean CTO registry who underwent a successful CTO intervention with drug-eluting stents (first generation, 1367, new generation, 967) were enrolled. The primary endpoint was the composite of cardiac death, myocardial infarction, and stent thrombosis...
May 24, 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/28540957/a-skin-integrated-transparent-and-stretchable-strain-sensor-with-interactive-color-changing-electrochromic-displays
#15
Heun Park, Dong Sik Kim, Soo Yeong Hong, Chulmin Kim, Jun Yeong Yun, Seung Yun Oh, Sang Woo Jin, Yu Ra Jeong, Gyu Tae Kim, Jeong Sook Ha
In this study, we report on the development of a stretchable, transparent, and skin-attachable strain sensor integrated with a flexible electrochromic device as a human skin-inspired interactive color-changing system. The strain sensor consists of a spin-coated conductive nanocomposite film of poly(vinyl alcohol)/multi-walled carbon nanotube/poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) on a polydimethylsiloxane substrate. The sensor exhibits excellent performance of high sensitivity, high durability, fast response, and high transparency...
May 25, 2017: Nanoscale
https://www.readbyqxmd.com/read/28540941/chiral-differentiation-of-d-and-l-alanine-by-permethylated-%C3%AE-cyclodextrin-irmpd-spectroscopy-and-dft-methods
#16
Sung-Sik Lee, Soojin Park, Yin Hong, Jae-Ung Lee, Jun-Hyeok Kim, Dongkyung Yoon, Xianglei Kong, Sungyul Lee, Han Bin Oh
The gaseous chiral differentiation of alanine by permethylated β-cyclodextrin was studied using IRMPD spectroscopy and density functional theory calculations. The protonated non-covalent complexes of permethylated β-cyclodextrin and d- or l-alanine were mass-selected and investigated by IR laser pulses in the wavelength region of 2650-3800 cm(-1). The remarkably different features of the IRMPD spectra for d- and l-alanine are described, and their origin is elucidated by quantum chemical calculations. We show that the differentiation of the experimentally observed spectral features is the result of different local interactions of d- and l-alanine with permethylated β-cyclodextrin...
May 25, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28539723/antimicrobial-and-anti-inflammatory-effects-of-ethanol-extract-of-corylopsis-coreana-uyeki-flos
#17
Da-Eon Park, In-Soo Yoon, Jung-Eun Kim, Ji-Hye Seo, Jin-Cheol Yoo, Chun-Sik Bae, Chang-Dai Lee, Dae-Hun Park, Seung-Sik Cho
BACKGROUND: Corylopsis coreana Uyeki (Hamamelidaceae) is a medicinal plant cultivated in Northeast Asia. Previously, we have reported that an ethanol extract of Corylopsis coreana Uyeki flos (ECCF) contains four active compounds with antioxidant activity. OBJECTIVE: The aim of this study was to investigate the antimicrobial spectrum against infectious bacteria and anti-inflammatory effect of ECCF in a mouse model of acute local inflammation. MATERIALS AND METHODS: In vitro antimicrobial susceptibility was evaluated using standard plate assay technique...
April 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28537994/changes-in-gait-parameters-after-femoral-derotational-osteotomy-in-cerebral-palsy-patients-with-medial-femoral-torsion
#18
Ha Yong Kim, Yong Han Cha, Jae Yong Byun, Young Sub Chun, Won Sik Choy
Medial femoral torsion (MFT) is a common pathologic gait in cerebral palsy (CP) children that can be corrected by femoral derotational osteotomy (FDO). It is not clearly known as to how much various gait parameters change after FDO. The aim of this study was to quantify changes in gait parameters after FDO. The study group included 19 young CP patients (28 limbs, age<20 years, average age: 13.2 years) with symptomatic MFT, treated with distal FDO. The study group was divided into two groups: the unilateral FDO group (UG) and the bilateral FDO group (BG)...
May 19, 2017: Journal of Pediatric Orthopedics. Part B
https://www.readbyqxmd.com/read/28536992/mgmt-promoter-methylation-status-as-a-prognostic-factor-for-the-outcome-of-gamma-knife-radiosurgery-for-recurrent-glioblastoma
#19
Byung Sup Kim, Doo-Sik Kong, Ho Jun Seol, Do-Hyun Nam, Jung-Il Lee
We conducted this study to determine whether the methylation status of the O(6)-methylguanine-DNA methyltransferase (MGMT) promoter was a prognostic marker for positive outcomes of gamma knife radiosurgery (GKS) for recurrent glioblastoma (GBM). We retrospectively examined 61 patients, who underwent GKS for local recurrent GBM between 2004 and 2015; in all patients, the methylation status of the MGMT promoter was identified via methylation-specific quantitative real-time polymerase chain reaction. All patients underwent surgical resection and were diagnosed histopathologically with GBM...
May 23, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28536694/validation-of-nomograms-for-survival-and-metastases-after-hysterectomy-and-adjuvant-therapy-in-uterine-cervical-cancer-with-risk-factors
#20
Won Sup Yoon, Dae Sik Yang, Jung Ae Lee, Nam Kwon Lee, Young Je Park, Chul Yong Kim, Nak Woo Lee, Jin Hwa Hong, Jae Kwan Lee, Jae Yun Song
Background. Three nomogram models for early stage uterine cervical cancer have been developed (KROG 13-03 for overall survival [OS], SNUH/AMC for disease-free survival [DFS], and KROG 12-08 for distant metastases-free survival [DMFS]) after radical hysterectomy (RH) and pelvic lymph node dissection (PLND). This study aimed to validate these models using our cohort with adjuvant radiotherapy. Methods. According to the eligibility criteria of nomogram studies, patients were enrolled in Group A (N = 109) for the two KROG models (RH with PLND and whole pelvic irradiation) and Group B (N = 101) for the SNUH/AMC model (RH with PLND and squamous histology)...
2017: BioMed Research International
keyword
keyword
39316
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"