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Na-Hee Jeong, Eun-Ju Yang, Meiling Jin, Jong Yeong Lee, Young-Ae Choi, Pil-Hoon Park, Sang-Rae Lee, Sun-Uk Kim, Tae-Yong Shin, Taeg Kyu Kwon, Yong Hyun Jang, Kyung-Sik Song, Sang-Hyun Kim
Atopic dermatitis (AD) is a common chronic inflammatory skin disorder afflicting from infancy to adults with itching, scratching, and lichenification. We aimed to investigate the effects of esculetin from Fraxinus rhynchophylla on atopic skin inflammation. For induction of atopic skin inflammation, we exposed the ears of female BALB/c mice to house dust mite (Dermatophagoides farinae extract, DFE) and 2,4-dinitrochlorobenzene (DNCB) for 4 weeks. Oral administration of esculetin reduced the symptoms of DFE/DNCB-induced atopic skin inflammation, which were evaluated based on ear swelling and number of scratch bouts...
April 12, 2018: International Immunopharmacology
Gyeong Han Jeong, Jae-Hyeon Cho, Cheorun Jo, Sungbeom Lee, Seung Sik Lee, Hyoung-Woo Bai, Byung Yeoup Chung, Tae Hoon Kim
Radiation is a promising technique for improving the safety and shelf-life of processed foods. In the present investigation, the degradation mechanism and bioactivity improvement of rosmarinic acid (RA) were studied in response to various gamma irradiation doses (10, 20, and 50 kGy). RA exposed to gamma irradiation at 50 kGy was completely degraded and showed an increased inhibitory effect against 3 T3-L1 preadipocyte compare to the parent compound. Structures of the newly generated compounds 2-4 from irradiated RA at 50 kGy were elucidated based on spectroscopic methods, including 1 H nuclear magnetic resonance (NMR) and mass spectrometry (MS)...
August 30, 2018: Food Chemistry
Dong Sik Kim, Eunae Lee
Fixed pattern noise due to nonuniform amplifier gains and scintillator sensitivity should be alleviated in radiography imaging to acquire low-noise x-ray images from detectors. Here, the noise property of the detector is usually evaluated observing the noise power spectrum (NPS). A gain-correction scheme, in which uniformly illuminated images are averaged to design a gain map, can be applied to alleviate the fixed pattern noise problem. The normalized NPS (NNPS) of the gain-corrected image decreases as the number of images for the average increases and converges to an infimum, which can be achieved if the fixed pattern noise is completely removed...
January 2018: Journal of Medical Imaging
Bharat Sharma, Jung-Sik Kim
A low power, dual-gate field-effect transistor (FET) hydrogen gas sensor with graphene decorated Pd-Ag for hydrogen sensing applications was developed. The FET hydrogen sensor was integrated with a graphene-Pd-Ag-gate FET (GPA-FET) as hydrogen sensor coupled with Pt-gate FET as a reference sensor on a single sensor platform. The sensing gate electrode was modified with graphene by an e-spray technique followed by Pd-Ag DC/MF sputtering. Morphological and structural properties were studied by FESEM and Raman spectroscopy...
April 12, 2018: Scientific Reports
Hyun Sik Kim, Mi Jung Kwon, Joon Ho Song, Eun Soo Kim, Ho Young Kim, Kyueng-Whan Min
IDH mutation and MGMT promoter methylation are reliable prognostic and predictive biomarkers in grade II-IV diffuse gliomas. Recurrent mutations in the promoter region of the telomerase reverse transcriptase (TERTp) gene have also been found in diffuse gliomas. However, the prognostic and predictive effects of TERTp mutation on IDH or MGMT status are largely unknown. IDH1/2 and TERTp mutations, as well as MGMT methylation statuses, were examined via peptide nucleic acid-mediated PCR clamping and MGMT methylation-specific PCR in 67 paraffinized tumor samples, respectively...
April 5, 2018: Pathology, Research and Practice
A-Young Lee, Hyun-Soo Ra, Dohyun Kwak, Jeong Min-Hye, Jeong-Hyun Park, Yeon-Su Kang, Weon-Sik Chae, Jong-Soo Lee
Recently, black phosphorus (BP) with direct band gap exhibited excellent potential for optoelectronic applications due to its high charge carrier mobility and low dark current as well as the variable band gap of 0.3 eV to 1.5 eV depending on the number of layers. However, few-layer BP-based phototransistors (photo-FETs) have been limited in sensitivity and wavelength selectivity. To overcome the drawback of these photo-FETs, we studied hybrid photo-FETs combined with the novel properties of the two materials between the channel and sensitizer layers...
April 13, 2018: ACS Applied Materials & Interfaces
Yun Sook Kim, Sung Kuk Kim, Jae Sik Lee, Sang Jin Ko, Yong Chul Bae
Transient receptor potential ankyrin 1 (TRPA1), a cold receptor in sensory neurons activated by a variety of stimuli, is implicated in nociception and mechanotransduction. To help understand the vesicular glutamate transporter (VGLUT)-mediated glutamate signaling in TRPA1-immunopositive (+) neurons, we examined the expression of VGLUT1 and VGLUT2 in the TRPA1+ neurons in the male rat trigeminal ganglion (n=19) under normal conditions and following experimental inflammation in the vibrissal pad by light microscopic immunohistochemistry (n=11), western blot (n=8), and quantitative analysis...
April 9, 2018: Brain Research
Min Suk Chae, Kwang Uck Moon, Hyun Sik Chung, Chul Soo Park, Jaemin Lee, Jong Ho Choi, Sang Hyun Hong
BACKGROUND: Liver graft regeneration is orchestrated by specific and sequential stimuli, including hepatocyte growth factors, cytokines, and catecholamines. We evaluated the association between preoperative serum cytokines and early liver graft regeneration in human living donor liver transplantation (LDLT). PATIENTS AND METHODS: We retrospectively reviewed the data of adult patients who underwent LDLT from January 2010 to December 2014. Serum cytokines, including interleukin (IL)-2, 6, 10, 12, 17, interferon (IFN)-γ and tumor necrosis factor (TNF)-α were measured in the recipients 1 day before surgery and on postoperative day (POD) 7...
2018: PloS One
Jong Soo Lee, Kang Su Cho, Seung Hwan Lee, Young Eun Yoon, Dong Hyuk Kang, Won Sik Jeong, Hae Do Jung, Jong Kyou Kwon, Joo Yong Lee
The aim of this study was to investigate the correlation between stone composition and single-energy noncontrast computed tomography (NCCT) parameters, including stone heterogeneity index (SHI) and mean stone density (MSD), in patients with urinary calculi. We retrospectively reviewed medical records of 255 patients who underwent operations or procedures for urinary stones or had spontaneous stone passage between December 2014 and October 2015. Among these, 214 patients with urinary calculi who underwent NCCT and stone composition analyses were included in the study...
2018: PloS One
Whoan Jeang Kim, Jae Won Lee, Seok Young Hwang, Kun Young Park, Shann Haw Chang, Dae Geon Song, Won Sik Choy
STUDY DESIGN: Prospective single center study. OBJECTIVE: The aim of this study was to evaluate 1) the activity of daily living (ADL) of three categorized patients group; over sixty-year old degenerative spine patients without adult spinal deformity (ASD), non-operative ASD patients, and operative ASD patients, 2) what kinds of activities would be impaired, and 3) how the ADL changes over time after long level fusion. SUMMARY OF BACKGROUND DATA: There is still debate how surgeons could decide treatment methods for old aged adult spinal deformity, operatively or not...
April 11, 2018: Spine
Ki Don Chang, Ali Abdel Raheem, Kwang Hyun Kim, Cheol Kyu Oh, Sung Yul Park, Young Sik Kim, Won Sik Ham, Woong Kyu Han, Young Deuk Choi, Byung Ha Chung, Koon Ho Rha
PURPOSE: Data regarding the long-term oncologic and functional outcomes of robotic-assisted, laparoscopic, and open partial nephrectomy (RPN, LPN and OPN) is lacking. Our aim was to compare outcomes among RPN, LPN and OPN with a 5-year median follow-up. PATIENTS AND METHODS: We retrospectively analyzed 1308 patients who underwent PN (RPN, n=380; LPN, n=206; OPN, n=722) between 2006 and 2012 at four academic centers. We performed 1:1:1 propensity score matching adjustment based on confounding variables among groups and 366 patients (122 in each group) were included in the final analysis...
April 12, 2018: BJU International
Bong-Kyu Kim, Jung-Min Kim, Myoung-Hee Kim, Do-Myung Paek, Seung-Sik Hwang, Mi-Na Ha, Young-Su Ju
Background: The Korea Radiation Effect & Epidemiology Cohort - The resident cohort (KREEC-R) study concluded that there is no epidemiological or causal evidence supporting any increase in cancer risks resulting from radiation from Korean nuclear power plants (NPPs). But the risks of thyroid cancer in women were significantly higher in residents living near NPPs than control. Debate about the cause of the pattern of thyroid cancer incidence in women is ongoing and some researchers argue that detection bias influenced the result of KREEC-R study...
2018: Annals of Occupational and Environmental Medicine
Eun Jung Kim, So Youn Park, Seung Eun Baek, Min A Jang, Won Suk Lee, Sun Sik Bae, Koanhoi Kim, Chi Dae Kim
Vascular smooth muscle cells (VSMCs) are the major cell type in the blood vessel walls, and their phenotypic modulation is a key cellular event driving vascular remodeling. Although high mobility group box-1 (HMGB1) plays a pivotal role in inflammatory processes after vascular injuries, the importance of the links between VSMCs, HMGB1 and vascular inflammation has not been clarified. To prove the hypothesis that VSMCs might be active players in vascular inflammation by secreting inflammatory cytokines, we investigated the proinflammatory effects of HMGB1 and its intermediary signaling pathways in VSMCs...
2018: Frontiers in Physiology
Sung Sill Lee, Do Hyung Kim, Shin Ja Lee, Da Som Oh, Il Dong Lee, Jun Sik Eom, Ha Young Park, Sung Ho Choi
Objective: This study was conducted to evaluate the effects of additional levels of Rhus succedanea extracts on in vitro ruminal fermentation and microbial growth. Methods: Two ruminally-fistulated steer consuming 600 g/kg timothy and 400 g/kg cracked corn-based concentrate with free access to water and mineral block were used as rumen fluid donors. In vitro batch fermentation supplied by the timothy as a substrate was conducted for up to 72 h with Rhus succedanea extracts which was dosed to achieve final concentrations of 0, 10, 30, 50, 70, and 90 mg/L, respectively...
April 12, 2018: Asian-Australasian Journal of Animal Sciences
Dahae Lee, Jae Sik Yu, Seoung Rak Lee, Gwi Seo Hwang, Ki Sung Kang, Jae Gyu Park, Hyun Young Kim, Ki Hyun Kim, Noriko Yamabe
Mulberry, the fruit of white mulberry tree ( Morus alba L., Moraceae), is commonly used in traditional Chinese medicines as a sedative, tonic, laxative, and emetic. In our continuing research of the bioactive metabolites from mulberry, chemical analysis of the fruits led to the isolation of five compounds, 1 - 5 . The compounds were identified as butyl pyroglutamate ( 1 ), quercetin 3- O -β-d-glucoside ( 2 ), kaempferol 3- O -β-d-rutinoside ( 3 ), rutin ( 4 ), and 2-phenylethyl d-rutinoside ( 5 ) by spectroscopic data analysis, comparing their nuclear magnetic resonance (NMR) data with those in published literature, and liquid chromatography-mass spectrometry analysis...
April 9, 2018: International Journal of Molecular Sciences
Eui-Baek Byun, Eun-Ji Cho, Yi-Eun Kim, Woo Sik Kim, Eui-Hong Byun
This study was carried out to evaluate the neuroprotective activity of polysaccharide extracts isolated from Perilla frutescens (PEPF) in H2 O2 -treated HT22 hippocampus cells. The PEPF treatment was found to increase the anti-oxidant activities of HT22 hippocampus cells. PEPF treatment resulted in a significant protection of HT22 hippocampus cells against H2 O2 -induced neurotoxicity, this protection ultimately occurred through an inhibition of ROS-mediated intracellular Ca2+ levels leading to MAPKs and NF-κB, as well as the accumulation of PI3K/AKT and Nrf2-mediated HO-1/NQO1 pathways...
April 8, 2018: Bioscience, Biotechnology, and Biochemistry
Gum Mo Jung, Seung Hyun Lee, Dae Seong Myung, Wan Sik Lee, Young Eun Joo, Mi Ran Jung, Seong Yeob Ryu, Young Kyu Park, Sung Bum Cho
Purpose: The endoscopic management of a fully covered self-expandable metal stent (SEMS) has been suggested for the primary treatment of patients with anastomotic leaks after total gastrectomy. Embedded stents due to tissue ingrowth and migration are the main obstacles in endoscopic stent management. Materials and Methods: The effectiveness and safety of endoscopic management were evaluated for anastomotic leaks when using a benign fully covered SEMS with an anchoring thread and thick silicone covering the membrane to prevent stent embedding and migration...
March 2018: Journal of Gastric Cancer
Kyung Min Kim, Yun-Sik Nam, Yeonhee Lee, Kang-Bong Lee
A highly sensitive and selective colorimetric assay for the detection of Hg2+ ions was developed using gold nanoparticles (AuNPs) conjugated with polyethyleneimine (PEI). The Hg2+ ion coordinates with PEI, decreasing the interparticle distance and inducing aggregation. Time-of-flight secondary ion mass spectrometry showed that the Hg2+ ion was bound to the nitrogen atoms of the PEI in a bidentate manner (N-Hg2+ -N), which resulted in a significant color change from light red to violet due to aggregation. Using this PEI-AuNP probe, determination of Hg2+ ion can be achieved by the naked eye and spectrophotometric methods...
2018: Journal of Analytical Methods in Chemistry
Nam Eun Kim, Hoon Ki Park, Kyong Min Park, Bong Kyung Seo, Kye Yeung Park, Hwan Sik Hwang
Background: The clinical practice examination (CPX) was introduced in 2010, and the Seoul-Gyeonggi CPX Consortium developed the patient-physician interaction (PPI) assessment tool in 2004. Both institutions use rating scales on classified sections of PPI but differ in their scoring of key components. This study investigated the accuracy of standardized patient scores across rating scales by comparing checklist methods and verified the concurrent validity of two comparable PPI rating tools...
March 2018: Korean Journal of Family Medicine
Jeehyun Kim, Hyuktae Kwon, Bo-Kyoung Heo, Hee-Kyung Joh, Cheol Min Lee, Seung-Sik Hwang, Danbee Park, Jae-Hong Park
Background: We investigated the association between body composition, especially truncal or non-truncal fat mass (FM), and bone mineral density (BMD) in premenopausal women in Korea. Methods: A cross-sectional study was performed using data from the Korea National Health and Nutrition Examination Survey IV and V (2008-2011). Total lean mass (LM), total FM (TFM), truncal FM, and non-truncal FM, and BMD of the total femur, femoral neck (FN), and lumbar spine were measured using dual-energy X-ray absorptiometry...
March 2018: Korean Journal of Family Medicine
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