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https://www.readbyqxmd.com/read/29332100/robot-assisted-radical-prostatectomy-is-more-beneficial-for-prostate-cancer-patients-a-system-review-and-meta-analysis
#1
Yuefeng Du, Qingzhi Long, Bin Guan, Lijun Mu, Juanhua Tian, Yumei Jiang, Xiaojing Bai, Dapeng Wu
BACKGROUND Robot-assisted radical prostatectomy (RARP) is increasingly used worldwide, but comparisons of perioperative, functional, and oncologic outcomes among RARP, laparoscopic radical prostatectomy (LRP), and open radical prostatectomy (ORP) remain inconsistent. MATERIAL AND METHODS Systematic literature searches were conducted using EMBASE, PubMed, the Cochrane Library, CNKI, and Science Direct/Elsevier up to April 2017. A meta-analysis was conducted using Review Manager and Stata software. RESULTS We included 33 studies...
January 14, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29315724/human-sperm-handling-in-intracytoplasmic-sperm-injection-processes-in-vitro-studies-on-mouse-oocyte-activation-embryo-development-competence-and-sperm-oxidation-reduction-potential
#2
S Roychoudhury, I Maldonado-Rosas, A Agarwal, S C Esteves, R Henkel, R Sharma
Polyvinylpyrrolidone (PVP) and hyaluronic acid (HA) are routinely used in handling spermatozoa for intracytoplasmic sperm injection (ICSI). As there are still concerns about possible adverse effects on the embryo, this study investigated sperm handling in a mouse ICSI model to (i) evaluate oocyte activation after injection of spermatozoa selected for rotational or linear motion in PVP; (ii) assess the effect of sperm selection in PVP, HA and medium on oocyte activation; (iii) examine the effects of PVP and HA on parthenogenetic oocyte activation and embryo development; and (iv) assess the oxidation-reduction potential (ORP) of spermatozoa exposed to PVP, HA or medium...
January 9, 2018: Andrologia
https://www.readbyqxmd.com/read/29273404/superior-biochemical-recurrence-and-long-term-quality-of-life-outcomes-are-achievable-with-robotic-radical-prostatectomy-after-a-long-learning-curve-updated-analysis-of-a-prospective-single-surgeon-cohort-of-2206-consecutive-cases
#3
James E Thompson, Sam Egger, Maret Böhm, Amila R Siriwardana, Anne-Maree Haynes, Jayne Matthews, Matthijs J Scheltema, Phillip D Stricker
BACKGROUND: Our earlier analysis suggested that robot-assisted radical prostatectomy (RARP) achieved superiority over open radical prostatectomy (ORP) in terms of positive surgical margin (PSM) rates and functional outcomes. OBJECTIVE: With larger sample size and longer follow-up, the objective of this study update is to assess whether our previous findings are upheld and whether the improved PSM rates for RARP after an initial learning curve compared with ORP-as observed in our earlier analysis-ultimately resulted in improved biochemical control...
December 19, 2017: European Urology
https://www.readbyqxmd.com/read/29244165/processing-conditions-and-endpoint-temperature-effects-on-development-of-pink-defect-without-pink-generating-ligands-in-cooked-ground-turkey-breast
#4
James R Claus, Jong Youn Jeong
This study was conducted to characterize the pink pigments associated with storing presalted (2%) and ground turkey breast trim at different processing conditions. Four treatments included: treatment (no NaCl, stored for 7 d before being cooked), treatment 2 (NaCl added and stored for 7 d before being cooked), treatment 3 (NaCl added and immediately cooked), and treatment 4 (stored for 7 d before NaCl added and cooked). All treatments were cooked to 4 endpoint temperatures (71.1, 73.9, 76.7, and 79.4°C). Processing conditions affected the pink defect in cooked ground turkey breast...
December 13, 2017: Poultry Science
https://www.readbyqxmd.com/read/29239627/clinical-severity-as-a-moderator-of-outcome-in-psychodynamic-and-dialectical-behavior-therapies-for-borderline-personality-disorder
#5
Zeynep Sahin, Bo Vinnars, Bernard S Gorman, Alexander Wilczek, Marie Åsberg, Jacques P Barber
The aim of the present study was to assess the effect of initial level of psychiatric severity on treatment outcome in psychodynamic therapy and dialectical behavior therapy (DBT) for borderline personality disorder (BPD). It was hypothesized that DBT would lead to better outcome for patients with high psychiatric severity, whereas dynamic treatment would lead to better outcome for patients with lower psychiatric severity. Data from the 5th-year follow-up of the Stockholm City Council's and the Karolinska Institute's Psychotherapy Project were used in the present study...
December 14, 2017: Personality Disorders
https://www.readbyqxmd.com/read/29237557/erepo-orp-exploring-the-opportunity-space-to-combat-orphan-diseases-with-existing-drugs
#6
Michal Brylinski, Misagh Naderi, Rajiv Gandhi Govindaraj, Jeffrey Lemoine
About 7000 rare, or orphan, diseases affect more than 350 million people worldwide. Although these conditions collectively pose significant health care problems, drug companies seldom develop drugs for orphan diseases due to extremely limited individual markets. Consequently, developing new treatments for often life-threatening orphan diseases is primarily contingent on financial incentives from governments, special research grants, and private philanthropy. Computer-aided drug repositioning is a cheaper and faster alternative to traditional drug discovery offering a promising venue for orphan drug research...
December 10, 2017: Journal of Molecular Biology
https://www.readbyqxmd.com/read/29222012/macrophage-immunomodulatory-activity-of-the-polysaccharide-isolated-from-collybia-radicata-mushroom
#7
Yufeng Wang, Youqiu Tian, Jiangjuan Shao, Xu Shu, Jinxia Jia, Xiaojie Ren, Yue Guan
Polysaccharides from Collybia radicata mushroom (CRP) possess many functions, such as antiviral, anti-aging and hypolipidemic activities. However, little is known about their immunomodulatory activity. To address this issue, we did a thorough research into their immune effects on murine macrophages. The results showed that the 14942Da polysaccharide not only obviously improved the proliferation and phagocytosis of macrophages, but also induced the secretion of nitric oxide (NO), inducible nitric oxide synthase (iNOS) and cytokines, such as tumor necrosis factor-α (TNF-α) and interleukin factors (IL-1β, IL-6 and IL-10)...
December 6, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29221784/assessment-of-intervention-related-changes-in-non-rapid-eye-movement-sleep-depth-importance-of-sleep-depth%C3%A2-changes-within-stage-2
#8
Sultan Qanash, Eleni Giannouli, Magdy Younes
OBJECTIVES: Depth of sleep within non-rapid-eye-movement (non-REM) stage-2 (N2-depth) varies from being nearly similar to stage-1 to nearly similar to stage-3. Differences in N2-depth are not captured by conventional indices of sleep depth (N1-N3 times, arousal/awakening index) when comparing sleep depth under different conditions. Magnitude of changes in N2-depth in the same individual under different experimental conditions, and the importance of measuring these changes are unknown...
December 2017: Sleep Medicine
https://www.readbyqxmd.com/read/29212368/impact-of-variations-in-prostatic-apex-shape-on-apical-margin-positive-rate-after-radical-prostatectomy-robot-assisted-laparoscopic-radical-prostatectomy-versus-open-radical-prostatectomy
#9
Young Dong Yu, Minseung Lee, Sung Kyu Hong, Seok-Soo Byun, Sang Eun Lee, Sangchul Lee
AIM: To evaluate the effects of prostatic apex shape variations on positive apical margin rate (PAM) after radical prostatectomy (RP) by undertaking a comparative study of robot-assisted laparoscopic radical prostatectomy (RALP) versus open radical prostatectomy (ORP). METHODS: A total 3,324 cases of RP (1,004 ORP and, 2,320 RALP) from January 2004 to March 2017 were retrospectively reviewed. All patients underwent preoperative magnetic resonance imaging (MRI) and the cohorts were stratified into 4 categories according to prostatic apical shape at the mid-sagittal plane...
December 6, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/29199365/volatile-fatty-acid-augmentation-and-microbial-community-responses-in-anaerobic-co-fermentation-process-of-waste-activated-sludge-mixed-with-corn-stalk-and-livestock-manure
#10
Xiaodong Xin, Junguo He, Wei Qiu
This study investigated the acidogenic and microbiological perspectives in the anaerobic co-fermentation of waste-activated sludge (WAS) mixed with corn stalk (CS) and pig manure (PM). The volatile fatty acids (VFAs) increased dramatically to over 5000 mg COD/L accumulation just within 4-5 days with the feedstock carbon to nitrogen (C/N) ratio regulation of 20/1. The CS and PM addition enhanced the compressibility of fermentation residuals by increasing the particle distribution spread index (DSI). Moreover, the external carbon addition conduced to bacterial consortia diversity rising and uneven population distribution in the co-fermentation, which contributed to VFAs accumulation potentially...
December 3, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29173820/orp-mediated-er-contact-with-endocytic-sites-facilitates-actin-polymerization
#11
Javier Encinar Del Dedo, Fatima-Zahra Idrissi, Isabel María Fernandez-Golbano, Patricia Garcia, Elena Rebollo, Marek K Krzyzanowski, Helga Grötsch, Maria Isabel Geli
Oxysterol binding protein-related proteins (ORPs) are conserved lipid binding polypeptides, enriched at ER contacts sites. ORPs promote non-vesicular lipid transport and work as lipid sensors in the context of many cellular tasks, but the determinants of their distinct localization and function are not understood. Here, we demonstrate that the yeast endocytic invaginations associate with the ER and that this association specifically requires the ORPs Osh2 and Osh3, which bridge the endocytic myosin-I Myo5 to the ER integral-membrane VAMP-associated protein (VAP) Scs2...
November 17, 2017: Developmental Cell
https://www.readbyqxmd.com/read/29162105/changing-oxidoreduction-potential-to-improve-water-soluble-yellow-pigment-production-with-monascus-ruber-cgmcc-10910
#12
Tao Huang, Hailing Tan, Fangju Lu, Gong Chen, Zhenqiang Wu
BACKGROUND: Monascus pigments are widely used in the food and pharmaceutical industries due to their safety to human health. Our previous study found that glucose concentration induced extracellular oxidoreduction potential (ORP) changes could influence extracellular water-soluble yellow pigment production by Monascus ruber CGMCC 10910 in submerged fermentation. In this study, H2O2 and dithiothreitol (DTT) were used to change the oxidoreduction potential for investigating the effects of oxidative or reductive substances on Monascus yellow pigment production by Monascus ruber CGMCC 10910...
November 21, 2017: Microbial Cell Factories
https://www.readbyqxmd.com/read/29145114/boosting-nannochloropsis-oculata-growth-and-lipid-accumulation-in-a-lab-scale-open-raceway-pond-characterized-by-improved-light-distributions-employing-built-in-planar-waveguide-modules
#13
Yahui Sun, Yun Huang, Qiang Liao, Ao Xia, Qian Fu, Xun Zhu, Jingwei Fu
Aiming at alleviating the adverse effect of poor light penetrability on microalgae growth, planar waveguide modules functioned as diluting and redistributing the intense incident light within microalgae culture more homogeneously were introduced into a lab-scale open raceway pond (ORP) for Nannochloropsis oculata cultivation. As compared to the conventional ORP, the illumination surface area to volume ratio and effective illuminated volume percentage in the proposed ORP were respectively improved by 5.53 times and 19...
November 6, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/29124237/oxidation-reduction-potential-as-a-new-marker-for-oxidative-stress-correlation-to-male-infertility
#14
REVIEW
Ashok Agarwal, Albert Danh Bui
Male infertility affects men worldwide. Oxidative stress (OS), characterized by an overabundance of reactive oxygen species (ROS) or a deficiency of antioxidants, is one of the major causes of male infertility. OS causes damage at the molecular level, which impairs lipids, proteins, and DNA. The cyclic cascade of redox reactions weakens sperm function which leads to poor semen parameters and eventual sterility. There is a need for advanced diagnostic tests that can quickly and accurately detect OS. Most commonly used assays can only measure single constituents of OS...
November 2017: Investigative and Clinical Urology
https://www.readbyqxmd.com/read/29113448/can-oxidation-reduction-potential-of-cerebrospinal-fluid-be-a-monitoring-biomarker-in-amyotrophic-lateral-sclerosis
#15
Milos Opacic, Zorica Stevic, Vladimir Bascarevic, Miroslav Zivic, Mihajlo Spasic, Ivan Spasojevic
The monitoring of progression in amyotrophic lateral sclerosis (ALS) relies on clinical outcome measures that take months to interpret, such as revised ALS functional rating scale (ALSFRS-R) score, with no approved biomarkers. A number of clinical studies have documented the involvement of oxidative stress in ALS pathology. Pertinent to this, we propose to evaluate oxidation-reduction potential (ORP) of cerebrospinal fluid (CSF) as a potential indicator of ALS progression. The case/control study included 24 patients with neurological non-neurodegenerative disorders (controls), and 82 ALS patients with different degrees of disease (ALSFRS-R score: 21-47)...
November 7, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/29098940/nitrogen-and-phosphorus-removal-processes-under-different-aeration-strength-in-principal-type-tank-of-alternate-multiple-tanks-system-and-process-control
#16
Zheqin Dai, Xiwu Lu, Zhaoqian Jing
The Alternate multiple tanks (AMT) system was originated by Southeast University to meet pressing requirements of new highly-compact sewage treatment with cost-effective balance and automated management. DO and ORP as economic monitoring indicators are closely linked to nutrients variations and controlling strategy. Thus this paper was to investigate the N and P periodic variations and removal mechanisms under different aeration strengths in scope of principal-type tank in AMT, and the relationship between nutrients and DO, ORP...
November 3, 2017: Environmental Technology
https://www.readbyqxmd.com/read/29090352/oxidation-reduction-potential-orp-is-predictive-of-complications-following-pediatric-cardiac-surgery
#17
Amy E Schmidt, Emily Gore, Kelly F Henrichs, Grace Conley, Charles Dorsey, Kimberly B Bjugstad, Majed A Refaai, Neil Blumberg, Jill M Cholette
Oxidation reduction potential (ORP) or Redox is the ratio of activity between oxidizers and reducers. Oxidative stress (OS) can cause cellular injury and death, and is important in the regulation of immune response to injury or disease. In the present study, we investigated changes in the redox system as a function of cardiopulmonary bypass (CPB) in pediatric patients. 664 plasma samples were collected from 162 pediatric patients having cardiac surgery of various CPB times. Lower ORP values at 12 h post-CPB were associated with poor survival rate (mean ± SD 167 ± 20 vs...
October 31, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/29080516/functional-characteristics-and-influence-factors-of-microbial-community-in-sewage-sludge-composting-with-inorganic-bulking-agent
#18
Ke Wang, Hailong Mao, Xiangkun Li
The metabolic function of microbial community dominated organics and nutrients transformation in aerobic composting process. In this study, the metabolic characteristics of bacterial and fungal communities were evaluated in 60 days composting of sludge and pumice by using FUNGuild and PICRUSt, respectively. The results showed that microbial community structure and metabolic characteristics were distinctively different at four composting periods. Bacterial genes related to carbohydrate metabolisms decreased during the first 30 days, but bacterial sequences associated with oxidative phosphorylation and fatty acids synthesis were enhanced in curing phase...
October 10, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/29063728/laparoscopic-and-robotic-assisted-versus-open-radical-prostatectomy-for-the-treatment-of-localised-prostate-cancer-a-cochrane-systematic-review
#19
Dragan Ilic, Sue M Evans, Christie Ann Allan, Jae Hung Jung, Declan Murphy, Mark Frydenberg
To determine the effects of laparoscopic radical prostatectomy (LRP), or robotic-assisted radical prostatectomy (RARP), compared to open radical prostatectomy (ORP) in men with localised prostate cancer. We performed a comprehensive search using multiple databases (CENTRAL, MEDLINE, EMBASE) and abstract proceedings with no restrictions on the language of publication or publication status, up until 9 June 2017. We included all randomised or pseudo-randomised controlled trials with a direct comparison of LRP and RARP to ORP...
October 24, 2017: BJU International
https://www.readbyqxmd.com/read/29057493/determination-of-seminal-oxidation-reduction-potential-orp-as-an-easy-and-cost-effective-clinical-marker-of-male-infertility
#20
A Agarwal, R Henkel, R Sharma, N N Tadros, E Sabanegh
Oxidative stress (OS) is an important contributing factor to male infertility. While previous methods to measure seminal OS are time-consuming and limited to the use of freshly produced semen, oxidation reduction potential (ORP) is easier and quicker to perform and can also be used in frozen semen. Therefore, this study evaluated the clinical utility of ORP as a potential marker of male infertility. ORP was measured in semen samples from 293 patients and 15 fertile controls and categorised according to WHO criteria as normozoospermic, oligozoospermic, asthenozoospermic, teratozoospermic and oligoasthenoteratozoospermic...
October 23, 2017: Andrologia
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