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https://www.readbyqxmd.com/read/28442716/a-puccinia-striiformis-f-sp-tritici-secreted-protein-activates-plant-immunity-at-the-cell-surface
#1
Bayantes Dagvadorj, Ahmet Caglar Ozketen, Ayse Andac, Cian Duggan, Tolga Osman Bozkurt, Mahinur S Akkaya
Pathogens secrete effector proteins to suppress host immunity, mediate nutrient uptake and subsequently enable parasitism. However, on non-adapted hosts, effectors can be detected as non-self by host immune receptors and activate non-host immunity. Nevertheless, the molecular mechanisms of effector triggered non-host resistance remain unknown. Here, we report that a small cysteine-rich protein PstSCR1 from the wheat rust pathogen Puccinia striiformis f. sp. tritici (Pst) activates immunity in the non-host solanaceous model plant Nicotiana benthamiana...
April 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28413947/novel-signaling-interface-constituted-with-membrane-receptor-like-kinases-emerged-from-the-study-of-interaction-and-transphosphorylation-of-bri1-and-bak1
#2
Cheng Li, Shan Zhang, Xiaofeng Wang
BRI1 and BAK1 are Receptor-Like Kinases (RLKs), one of the largest gene families in plants participating in various cell signal transduction from cell surface to cytoplasm with oligomerization and phosphorylation to regulate plant growth, development, immunity, and environmental responses. Based on the recent investigations on the BRI1 and BAK1 and other RLKs involving in the receptor complex formation, trans phosphorylation, phosphorylation sites identification, downstream substrates identification, and so on, it is recovered that the receptors oligomerization and phosphorylation integrate multiple distinct signaling to realize signaling modulation, divergence, convergence, and specificity...
April 14, 2017: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/28406987/arabidopsis-leucine-rich-repeat-receptor-like-kinase-nilr1-is-required-for-induction-of-innate-immunity-to-parasitic-nematodes
#3
Badou Mendy, Mary Wanjiku Wang'ombe, Zoran S Radakovic, Julia Holbein, Muhammad Ilyas, Divykriti Chopra, Nick Holton, Cyril Zipfel, Florian M W Grundler, Shahid Siddique
Plant-parasitic nematodes are destructive pests causing losses of billions of dollars annually. An effective plant defence against pathogens relies on the recognition of pathogen-associated molecular patterns (PAMPs) by surface-localised receptors leading to the activation of PAMP-triggered immunity (PTI). Extensive studies have been conducted to characterise the role of PTI in various models of plant-pathogen interactions. However, far less is known about the role of PTI in roots in general and in plant-nematode interactions in particular...
April 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28394519/-genetic-risk-factors-for-sporadic-germ-cell-testicular-tumors
#4
M V Nemtsova, E V Ivkin, A A Tryakin, V V Rudenko, I S Dantsev, S A Tyulyandin, O B Loran
INTRODUCTION: Approximately 95% of all testicular cancers are testicular germ cell tumors (GCTTs), represented by seminoma and nonseminoma germ cell testicular cancer. There is a hypothesis that the formation of GCTTs begins in early embryogenesis being a part of testicular dysgenesis syndrome (TDS). AIM: To determine the role of genetic factors in the development of GCTTs. MATERIALS AND METHODS: We studied the frequency of alleles and genotypes KITLG (rs995030, rs1508595), SPRY4 (rs4624820, rs6897876) and BAK1 (rs210138) in 97 fertile men (control), and 73 patients with GCTTs (34 seminoma and 39 nonseminoma)...
April 2017: Urologii︠a︡
https://www.readbyqxmd.com/read/28390899/proteomic-analysis-of-arabidopsis-plasma-membranes-reveals-lipopolysaccharide-responsive-changes
#5
Nwaxigombe M Baloyi, Ian A Dubery, Lizelle A Piater
Plant plasma membranes (PMs) contain pattern recognition receptors (PRRs), lately believed to be associated within multicomponent complexes, which perceive microbe-associated molecular pattern (MAMP) molecules like lipopolysaccharides (LPSs) and result in signal transduction events that lead to activated immune defense responses. As such, Arabidopsis thaliana leaves were treated with LPS from Escherichia coli (LPSE.coli) over time, and PM fractions isolated and evaluated using gel-based and subsequent mass spectrometry approaches for identification of LPS-responsive proteins...
May 13, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28350074/n-terminal-polypeptide-derived-from-vmip-ii-exerts-its-antitumor-activity-by-inhibiting-the-cxcr4-pathway-in-human-glioma
#6
Qingling Yang, Haihua Wu, Haifeng Wang, Yu Li, Lingyu Zhang, Lihua Zhu, Wenrui Wang, Jihong Zhou, Yingxiao Fu, Sulian Chen, Qiong Wu, Changjie Chen, Congzhao Zhou
Emerging evidence demonstrates that the stromal derived factor-1 (SDF-1α)/CXCR4 axis is associated with tumor aggressiveness and metastasis, including glioma, the most common brain cancer. In the present study, we demonstrated that a novel designed peptide NT21MP of viral macrophage inflammatory protein II, targeting CXCR4 inhibits SDF-1α-induced activation in glioma. The effects of NT21MP on CXCR4 expression, cell survival and migration were assessed on the human glioma cell line U251 and SHG-44 exposed to SDF-1α, by western blotting, MTT assay, flow cytometry and transwell migration assay...
March 8, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28295819/variants-in-bak1-spry4-and-gab2-are-associated-with-pediatric-germ-cell-tumors-a-report-from-the-children-s-oncology-group
#7
Erin L Marcotte, Nathan Pankratz, James F Amatruda, A Lindsay Frazier, Mark Krailo, Stella Davies, Jacqueline R Starr, Ching C Lau, Michelle Roesler, Erica Langer, Caroline Hallstrom, Anthony J Hooten, Jenny N Poynter
Germ cell tumors (GCT) are a rare form of childhood cancer that originate from the primordial germ cell. Recent genome-wide association studies (GWAS) have identified susceptibility alleles for adult testicular GCT (TGCT). We test whether these SNPs are associated with GCT in pediatric and adolescent populations. This case-parent triad study includes individuals with GCT diagnosed between ages 0 and 19. We evaluated 26 SNPs from GWAS of adult TGCT and estimated main effects for pediatric GCT within complete trios (N = 366) using the transmission disequilibrium test...
March 13, 2017: Genes, Chromosomes & Cancer
https://www.readbyqxmd.com/read/28256105/cis-nerolidol-induces-endoplasmic-reticulum-stress-and-cell-death-in-human-hepatocellular-carcinoma-cells-through-extensive-cyp2c19-and-cyp1a2-oxidation
#8
Bruna Isabela Biazi, Thalita Alves Zanetti, Adrivanio Baranoski, Amanda Cristina Corveloni, Mário Sérgio Mantovani
Of late, many studies are attempting to find new molecules with anti-cancer properties, especially those with the capability to inhibit cell growth. The aim of this work was to evaluate nerolidol, a plant-based compound, as its cytotoxicity, genotoxicity, antiproliferative and apoptotic induction, cell cycle, mitochondrial membrane potential, and RT-qPCR of transcripts related to those pathways in the human hepatocellular carcinoma cell line (HepG2/C3A). Only cis-nerolidol (C-NER) demonstrated cytotoxicity (100 to 250 μM) activity and was selected to conduct the following experiments...
March 2, 2017: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28224059/identification-of-downy-mildew-resistance-gene-candidates-by-positional-cloning-in-maize-zea-mays-subsp-mays-poaceae
#9
Jae Yoon Kim, Jun-Cheol Moon, Hyo Chul Kim, Seungho Shin, Kitae Song, Kyung-Hee Kim, Byung-Moo Lee
PREMISE OF THE STUDY: Positional cloning in combination with phenotyping is a general approach to identify disease-resistance gene candidates in plants; however, it requires several time-consuming steps including population or fine mapping. Therefore, in the present study, we suggest a new combined strategy to improve the identification of disease-resistance gene candidates. METHODS AND RESULTS: Downy mildew (DM)-resistant maize was selected from five cultivars using a spreader row technique...
February 2017: Applications in Plant Sciences
https://www.readbyqxmd.com/read/28215535/ambra1-a-novel-bh3-like-protein-new-insights-into-the-ambra1-bcl2-family-proteins-relationship
#10
A Di Rita, F Strappazzon
Cellular homeostasis swings like a pendulum backward and forward between life and death. Two of the main processes, which regulate this equilibrium, are autophagy and apoptosis. While autophagy is a highly conserved self-digestion mechanism that mediates degradation of damaged or surplus components, apoptosis is a programmed cell suicide in which typical death signals induce the elimination of undesired cells. Both these processes are highly regulated by complex molecular machineries, including some common proteins whose "dual role" favors one process or the other...
2017: International Review of Cell and Molecular Biology
https://www.readbyqxmd.com/read/28213497/mitochondrial-damage-elicits-a-tcdd-inducible-poly-adp-ribose-polymerase-mediated-antiviral-response
#11
Tatsuya Kozaki, Jun Komano, Daiki Kanbayashi, Michihiro Takahama, Takuma Misawa, Takashi Satoh, Osamu Takeuchi, Taro Kawai, Shigeomi Shimizu, Yoshiharu Matsuura, Shizuo Akira, Tatsuya Saitoh
The innate immune system senses RNA viruses by pattern recognition receptors (PRRs) and protects the host from virus infection. PRRs mediate the production of immune modulatory factors and direct the elimination of RNA viruses. Here, we show a unique PRR that mediates antiviral response. Tetrachlorodibenzo-p-dioxin (TCDD)-inducible poly(ADP ribose) polymerase (TIPARP), a Cysteine3 Histidine (CCCH)-type zinc finger-containing protein, binds to Sindbis virus (SINV) RNA via its zinc finger domain and recruits an exosome to induce viral RNA degradation...
March 7, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28205292/verticillium-dahliae-manipulates-plant-immunity-by-glycoside-hydrolase-12-proteins-in-conjunction-with-carbohydrate-binding-module-1
#12
Yue-Jing Gui, Jie-Yin Chen, Dan-Dan Zhang, Nan-Yang Li, Ting-Gang Li, Wen-Qi Zhang, Xin-Yan Wang, Dylan P G Short, Lei Li, Wei Guo, Zhi-Qiang Kong, Yu-Ming Bao, Krishna V Subbarao, Xiao-Feng Dai
Glycoside hydrolase 12 (GH12) proteins act as virulence factors and pathogen-associated molecular patterns (PAMPs) in oomycetes. However, the pathogenic mechanisms of fungal GH12 proteins have not been characterized. In this study, we demonstrated that two of the six GH12 proteins produced by the fungus Verticillium dahliae Vd991, VdEG1 and VdEG3 acted as PAMPs to trigger cell death and PAMP-triggered immunity (PTI) independent of their enzymatic activity in Nicotiana benthamiana. A 63-amino-acid peptide of VdEG3 was sufficient for cell death-inducing activity, but this was not the case for the corresponding peptide of VdEG1...
February 15, 2017: Environmental Microbiology
https://www.readbyqxmd.com/read/28187200/ligand-induced-dynamics-of-heterotrimeric-g-protein-coupled-receptor-like-kinase-complexes
#13
Meral Tunc-Ozdemir, Alan M Jones
BACKGROUND: Arabidopsis, 7-transmembrane Regulator of G signaling protein 1 (AtRGS1) modulates canonical G protein signaling by promoting the inactive state of heterotrimeric G protein complex on the plasma membrane. It is known that plant leucine-rich repeat receptor-like kinases (LRR RLKs) phosphorylate AtRGS1 in vitro but little is known about the in vivo interaction, molecular dynamics, or the cellular consequences of this interaction. METHODS: Therefore, a subset of the known RLKs that phosphorylate AtRGS1 were selected for elucidation, namely, BAK1, BIR1, FLS2...
2017: PloS One
https://www.readbyqxmd.com/read/28153720/overexpression-of-bak1-causes-salicylic-acid-accumulation-and-deregulation-of-cell-death-control-genes
#14
Sun Young Kim, Yun Shang, Se-Hwan Joo, Seong-Ki Kim, Kyoung Hee Nam
Since the BRI1-Associated Receptor Kinase 1 (BAK1) was firstly identified as a co-receptor of BRI1 that mediates brassinosteroids (BR) signaling, the functional roles of BAK1, as a versatile co-receptor for various ligand-binding leucine-rich repeat (LRR)-containing receptor-like kinase (RLKs), are being extended to involvement with plant immunity, cell death, stomatal development and ABA signaling in plants. During more than a decade of research on the BAK1, it has been known that transgenic Arabidopsis plants overexpressing BAK1 tagged with various reporters do not fully represent its natural functions...
January 31, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28140520/microrna-125a-promotes-resistance-to-braf-inhibitors-through-suppression-of-the-intrinsic-apoptotic-pathway
#15
Lisa Koetz-Ploch, Douglas Hanniford, Igor Dolgalev, Elena Sokolova, Judy Zhong, Marta Díaz-Martínez, Emily Bernstein, Farbod Darvishian, Keith T Flaherty, Paul B Chapman, Hussein Tawbi, Eva Hernando
Melanoma patients with BRAF(V)(600E) -mutant tumors display striking responses to BRAF inhibitors (BRAFi); however, almost all invariably relapse with drug-resistant disease. Here, we report that microRNA-125a (miR-125a) expression is upregulated in human melanoma cells and patient tissues upon acquisition of BRAFi resistance. We show that miR-125a induction confers resistance to BRAF(V)(600E) melanoma cells to BRAFi by directly suppressing pro-apoptotic components of the intrinsic apoptosis pathway, including BAK1 and MLK3...
January 31, 2017: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/28124252/identification-of-brassinosteroid-signaling-complexes-by-coimmunoprecipitation-and-mass-spectrometry
#16
Walter van Dongen, Luc van Heerde, Sjef Boeren, Sacco C de Vries
A combination of coimmunoprecipitation (coIP) of tagged proteins followed by protein identification and quantitation using Liquid Chromatography Mass Spectrometry/Mass Spectrometry (LCMS/MS) has proven to be a reliable method to qualitatively characterize membrane-bound receptor complexes from plants. Success depends on a range of parameters, such as abundance and stability of the complex and functionality of the tagged receptors, efficiency of the protein complex isolation procedure, MS equipment, and analysis software in use...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28114413/visualization-of-bri1-and-serk3-bak1-nanoclusters-in-arabidopsis-roots
#17
Stefan J Hutten, Danny S Hamers, Marije Aan den Toorn, Wilma van Esse, Antsje Nolles, Christoph A Bücherl, Sacco C de Vries, Johannes Hohlbein, Jan Willem Borst
Brassinosteroids (BRs) are plant hormones that are perceived at the plasma membrane (PM) by the ligand binding receptor BRASSINOSTEROID-INSENSITIVE1 (BRI1) and the co-receptor SOMATIC EMBRYOGENESIS RECEPTOR LIKE KINASE 3/BRI1 ASSOCIATED KINASE 1 (SERK3/BAK1). To visualize BRI1-GFP and SERK3/BAK1-mCherry in the plane of the PM, variable-angle epifluorescence microscopy (VAEM) was employed, which allows selective illumination of a thin surface layer. VAEM revealed an inhomogeneous distribution of BRI1-GFP and SERK3/BAK1-mCherry at the PM, which we attribute to the presence of distinct nanoclusters...
2017: PloS One
https://www.readbyqxmd.com/read/28104890/the-receptor-kinase-fer-is-a-ralf-regulated-scaffold-controlling-plant-immune-signaling
#18
Martin Stegmann, Jacqueline Monaghan, Elwira Smakowska-Luzan, Hanna Rovenich, Anita Lehner, Nicholas Holton, Youssef Belkhadir, Cyril Zipfel
In plants, perception of invading pathogens involves cell-surface immune receptor kinases. Here, we report that the Arabidopsis SITE-1 PROTEASE (S1P) cleaves endogenous RAPID ALKALINIZATION FACTOR (RALF) propeptides to inhibit plant immunity. This inhibition is mediated by the malectin-like receptor kinase FERONIA (FER), which otherwise facilitates the ligand-induced complex formation of the immune receptor kinases EF-TU RECEPTOR (EFR) and FLAGELLIN-SENSING 2 (FLS2) with their co-receptor BRASSINOSTEROID INSENSITIVE 1-ASSOCIATED KINASE 1 (BAK1) to initiate immune signaling...
January 20, 2017: Science
https://www.readbyqxmd.com/read/28064312/-polymorphisms-of-kitlg-spry4-and-bak1-genes-in-patients-with-testicular-germ-cell-tumors-and-individuals-with-infertility-associated-with-azfc-deletion-of-the-y-chromosome
#19
M V Nemtsova, E V Ivkin, O A Simonova, V V Rudenko, V B Chernykh, D S Mikhaylenko, O B Loran
Testicular cancer is the most common form of solid cancer in young men. Testicular cancer is represented by testicular germ cell tumors (TGCTs) derived from embryonic stem cells with different degrees of differentiation in about 95% of cases. The development of these tumors is related to the formation of a pool of male germ cells and gametogenesis. Clinical factors that are predisposed to the development of germ-cell tumors include cryptorchidism and testicular microlithiasis, as well as infertility associated with the gr/gr deletion within the AZFс locus...
November 2016: Molekuliarnaia Biologiia
https://www.readbyqxmd.com/read/27995670/the-tomato-i-gene-for-fusarium-wilt-resistance-encodes-an-atypical-leucine-rich-repeat-receptor-like-protein-whose-function-is-nevertheless-dependent-on-sobir1-and-serk3-bak1
#20
Ann-Maree Catanzariti, Huong T T Do, Pierrick Bru, Mara de Sain, Louise F Thatcher, Martijn Rep, David A Jones
We have identified the tomato I gene for resistance to the Fusarium wilt fungus Fusarium oxysporum f. sp. lycopersici (Fol) and show that it encodes a membrane-anchored leucine-rich repeat receptor-like protein (LRR-RLP). Unlike most other LRR-RLP genes involved in plant defence, the I gene is not a member of a gene cluster and contains introns in its coding sequence. The I gene encodes a loopout domain larger than those in most other LRR-RLPs, with a distinct composition rich in serine and threonine residues...
December 20, 2016: Plant Journal: for Cell and Molecular Biology
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