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https://www.readbyqxmd.com/read/28578021/transcriptome-profiling-of-the-floral-buds-and-discovery-of-genes-related-to-sex-differentiation-in-the-dioecious-cucurbit-coccinia-grandis-l-voigt
#1
Jatindra Nath Mohanty, Sanghamitra Nayak, Sumita Jha, Raj Kumar Joshi
Dioecious species offer an inclusive structure to study the molecular basis of sexual dimorphism in angiosperms. Despite having a small genome and heteromorphic sex chromosomes, Coccinia grandis is a highly neglected dioecious species with little information available on its physical state, genetic orientation and key sex-defining elements. In the present study, we performed RNA-Seq and DGE analysis of male (MB) and female (FB) buds in C. grandis to gain insights into the molecular basis of sex determination in this plant...
May 31, 2017: Gene
https://www.readbyqxmd.com/read/28559475/interplay-of-plasma-membrane-and-vacuolar-ion-channels-together-with-bak1-elicits-rapid-cytosolic-calcium-elevations-in-arabidopsis-during-aphid-feeding
#2
Thomas R Vincent, Marieta Avramova, James Canham, Peter Higgins, Natasha Bilkey, Sam T Mugford, Marco Pitino, Masatsugu Toyota, Simon Gilroy, Tony J Miller, Saskia Hogenhout, Dale Sanders
A transient rise in cytosolic calcium ion concentration is one of the main signals used by plants in perception of their environment. The role of calcium in the detection of abiotic stress is well documented; however, its role during biotic interactions remains unclear. Here, we use a fluorescent calcium biosensor (GCaMP3) in combination with the green peach aphid (Myzus persicae) as a tool to study Arabidopsis thaliana calcium dynamics in vivo and in real time during a live biotic interaction. We demonstrate rapid and highly-localised plant calcium elevations around the feeding sites of M...
May 30, 2017: Plant Cell
https://www.readbyqxmd.com/read/28559283/molecular-dynamics-simulations-reveal-the-conformational-dynamics-of-arabidopsis-thaliana-bri1-and-bak1-receptor-like-kinases
#3
Alexander S Moffett, Kyle W Bender, Steven C Huber, Diwakar Shukla
The structural motifs responsible for activation and regulation of eukaryotic protein kinases in animals have been studied extensively in recent years, and a coherent picture of their activation mechanisms has begun to emerge. On the other hand, non-animal eukaryotic protein kinases are not as well understood from a structural perspective, representing a large knowledge gap. To this end, we investigated the conformational dynamics of two key Arabidopsis thaliana receptor-like kinases, brassi- nosteroid insensitive 1 (BRI1) and BRI1-associated kinase 1 (BAK1), through extensive molecular dynamics (MD) simulations of their fully phosphorylated kinase domains...
May 30, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28540949/structure-based-in-silico-identification-of-potentially-non-steroidal-brassinosteroids-mimics
#4
Beilei Lei, Ningjuan Heng, Xiaoxue Dang, Jiyuan Liu, Xiaojun Yao, Cunli Zhang
Brassinosteroids (BRs) are a class of plant steroid hormones that play indispensable roles in cell elongation, division and plant development. To date, the numerous synthesis of BRs analogs and structure-activity relationship investigations have clearly revealed the key substituent groups relevant to the steroidal activity of BRs. However, due to the limited chemical space studied, the efforts for alternative non-steroidal compounds have produced no remarkable results. To identify potentially non-steroidal BR mimics in this study, vital interacting pharmacophore features were extracted starting from several complex structures of BRs that bound with the receptor Brassinosteroid-Insentive 1 (BRI1) and co-receptor BRI1-associated kinase 1 (BAK1), which were characterized and merged into one comprehensive pharmacophore model...
June 27, 2017: Molecular BioSystems
https://www.readbyqxmd.com/read/28487714/both-light-induced-sa-accumulation-and-eti-mediators-contribute-to-the-cell-death-regulated-by-bak1-and-bkk1
#5
Yang Gao, Yujun Wu, Junbo Du, Yanyan Zhan, Doudou Sun, Jianxin Zhao, Shasha Zhang, Jia Li, Kai He
Receptor-like kinases BAK1 and BKK1 modulate multiple cellular processes including brassinosteroid signaling and PRR-mediated PTI in Arabidopsis. Our previous reports also demonstrated that bak1 bkk1 double mutants exhibit a spontaneous cell death phenotype under normal growth condition. With an unknown mechanism, the cell death in bak1 bkk1 is significantly suppressed when grown in dark but can be quickly induced by light. Furthermore, little is known about intrinsic components involved in BAK1 and BKK1-regulated cell death pathway...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28461403/scanning-for-new-bri1-receptor-mutations-via-tilling-analysis
#6
Chao Sun, Kan Yan, Jian-Ting Han, Liang Tao, Minghui Lv, Tao Shi, Yong-Xing He, Michael Wierzba, Frans Tax, Jia Li
Identification and characterization of a mutational spectrum for a specific protein can help to elucidate its detailed cellular functions. BRI1, a multidomain transmembrane receptor-like kinase, is a major receptor of brassinosteroids in Arabidopsis. Within the last two decades, over 20 different bri1 mutant alleles have been identified, which helped to determine the significance of each domain within BRI1. To further understand molecular mechanisms of BRI1, we tried to identify additional alleles via TILLING...
May 1, 2017: Plant Physiology
https://www.readbyqxmd.com/read/28458047/a-look-at-plant-immunity-through-the-window-of-the-multitasking-coreceptor-bak1
#7
REVIEW
Shigetaka Yasuda, Kentaro Okada, Yusuke Saijo
Recognition of microbe- and danger-associated molecular patterns (MAMPs and DAMPs, respectively) by pattern recognition receptors (PRRs) is central to innate immunity in both plants and animals. The plant PRRs described to date are all cell surface-localized receptors. According to their ligand-binding ectodomains, each PRR engages a specific coreceptor or adaptor kinase in its signaling complexes to regulate defense signaling. With a focus on the coreceptor RLK BRI1-ASSOCIATED RECEPTOR KINASE1 (BAK1) and related SOMATIC EMBRYOGENESIS RECEPTOR KINASEs (SERKs), here we review the increasing inventory of BAK1 partners and their functions in plant immunity...
April 27, 2017: Current Opinion in Plant Biology
https://www.readbyqxmd.com/read/28442716/a-puccinia-striiformis-f-sp-tritici-secreted-protein-activates-plant-immunity-at-the-cell-surface
#8
Bayantes Dagvadorj, Ahmet Caglar Ozketen, Ayse Andac, Cian Duggan, Tolga Osman Bozkurt, Mahinur S Akkaya
Pathogens secrete effector proteins to suppress host immunity, mediate nutrient uptake and subsequently enable parasitism. However, on non-adapted hosts, effectors can be detected as non-self by host immune receptors and activate non-host immunity. Nevertheless, the molecular mechanisms of effector triggered non-host resistance remain unknown. Here, we report that a small cysteine-rich protein PstSCR1 from the wheat rust pathogen Puccinia striiformis f. sp. tritici (Pst) activates immunity in the non-host solanaceous model plant Nicotiana benthamiana...
April 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28413947/novel-signaling-interface-constituted-with-membrane-receptor-like-kinases-emerged-from-the-study-of-interaction-and-transphosphorylation-of-bri1-and-bak1
#9
Cheng Li, Shan Zhang, Xiaofeng Wang
BRI1 and BAK1 are Receptor-Like Kinases (RLKs), one of the largest gene families in plants participating in various cell signal transduction from cell surface to cytoplasm with oligomerization and phosphorylation to regulate plant growth, development, immunity, and environmental responses. Based on the recent investigations on the BRI1 and BAK1 and other RLKs involving in the receptor complex formation, trans phosphorylation, phosphorylation sites identification, downstream substrates identification, and so on, it is recovered that the receptors oligomerization and phosphorylation integrate multiple distinct signaling to realize signaling modulation, divergence, convergence, and specificity...
April 14, 2017: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/28406987/arabidopsis-leucine-rich-repeat-receptor-like-kinase-nilr1-is-required-for-induction-of-innate-immunity-to-parasitic-nematodes
#10
Badou Mendy, Mary Wanjiku Wang'ombe, Zoran S Radakovic, Julia Holbein, Muhammad Ilyas, Divykriti Chopra, Nick Holton, Cyril Zipfel, Florian M W Grundler, Shahid Siddique
Plant-parasitic nematodes are destructive pests causing losses of billions of dollars annually. An effective plant defence against pathogens relies on the recognition of pathogen-associated molecular patterns (PAMPs) by surface-localised receptors leading to the activation of PAMP-triggered immunity (PTI). Extensive studies have been conducted to characterise the role of PTI in various models of plant-pathogen interactions. However, far less is known about the role of PTI in roots in general and in plant-nematode interactions in particular...
April 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28394519/-genetic-risk-factors-for-sporadic-germ-cell-testicular-tumors
#11
M V Nemtsova, E V Ivkin, A A Tryakin, V V Rudenko, I S Dantsev, S A Tyulyandin, O B Loran
INTRODUCTION: Approximately 95% of all testicular cancers are testicular germ cell tumors (GCTTs), represented by seminoma and nonseminoma germ cell testicular cancer. There is a hypothesis that the formation of GCTTs begins in early embryogenesis being a part of testicular dysgenesis syndrome (TDS). AIM: To determine the role of genetic factors in the development of GCTTs. MATERIALS AND METHODS: We studied the frequency of alleles and genotypes KITLG (rs995030, rs1508595), SPRY4 (rs4624820, rs6897876) and BAK1 (rs210138) in 97 fertile men (control), and 73 patients with GCTTs (34 seminoma and 39 nonseminoma)...
April 2017: Urologii︠a︡
https://www.readbyqxmd.com/read/28390899/proteomic-analysis-of-arabidopsis-plasma-membranes-reveals-lipopolysaccharide-responsive-changes
#12
Nwaxigombe M Baloyi, Ian A Dubery, Lizelle A Piater
Plant plasma membranes (PMs) contain pattern recognition receptors (PRRs), lately believed to be associated within multicomponent complexes, which perceive microbe-associated molecular pattern (MAMP) molecules like lipopolysaccharides (LPSs) and result in signal transduction events that lead to activated immune defense responses. As such, Arabidopsis thaliana leaves were treated with LPS from Escherichia coli (LPSE.coli) over time, and PM fractions isolated and evaluated using gel-based and subsequent mass spectrometry approaches for identification of LPS-responsive proteins...
May 13, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28350074/n-terminal-polypeptide-derived-from-vmip-ii-exerts-its-antitumor-activity-by-inhibiting-the-cxcr4-pathway-in-human-glioma
#13
Qingling Yang, Haihua Wu, Haifeng Wang, Yu Li, Lingyu Zhang, Lihua Zhu, Wenrui Wang, Jihong Zhou, Yingxiao Fu, Sulian Chen, Qiong Wu, Changjie Chen, Congzhao Zhou
Emerging evidence demonstrates that the stromal derived factor-1 (SDF-1α)/CXCR4 axis is associated with tumor aggressiveness and metastasis, including glioma, the most common brain cancer. In the present study, we demonstrated that a novel designed peptide NT21MP of viral macrophage inflammatory protein II, targeting CXCR4 inhibits SDF-1α-induced activation in glioma. The effects of NT21MP on CXCR4 expression, cell survival and migration were assessed on the human glioma cell line U251 and SHG-44 exposed to SDF-1α, by western blotting, MTT assay, flow cytometry and transwell migration assay...
March 8, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28295819/variants-in-bak1-spry4-and-gab2-are-associated-with-pediatric-germ-cell-tumors-a-report-from-the-children-s-oncology-group
#14
Erin L Marcotte, Nathan Pankratz, James F Amatruda, A Lindsay Frazier, Mark Krailo, Stella Davies, Jacqueline R Starr, Ching C Lau, Michelle Roesler, Erica Langer, Caroline Hallstrom, Anthony J Hooten, Jenny N Poynter
Germ cell tumors (GCT) are a rare form of childhood cancer that originate from the primordial germ cell. Recent genome-wide association studies (GWAS) have identified susceptibility alleles for adult testicular GCT (TGCT). We test whether these SNPs are associated with GCT in pediatric and adolescent populations. This case-parent triad study includes individuals with GCT diagnosed between ages 0 and 19. We evaluated 26 SNPs from GWAS of adult TGCT and estimated main effects for pediatric GCT within complete trios (N = 366) using the transmission disequilibrium test...
July 2017: Genes, Chromosomes & Cancer
https://www.readbyqxmd.com/read/28256105/cis-nerolidol-induces-endoplasmic-reticulum-stress-and-cell-death-in-human-hepatocellular-carcinoma-cells-through-extensive-cyp2c19-and-cyp1a2-oxidation
#15
Bruna Isabela Biazi, Thalita Alves Zanetti, Adrivanio Baranoski, Amanda Cristina Corveloni, Mário Sérgio Mantovani
Of late, many studies are attempting to find new molecules with anti-cancer properties, especially those with the capability to inhibit cell growth. The aim of this work was to evaluate nerolidol, a plant-based compound, as its cytotoxicity, genotoxicity, antiproliferative and apoptotic induction, cell cycle, mitochondrial membrane potential, and RT-qPCR of transcripts related to those pathways in the human hepatocellular carcinoma cell line (HepG2/C3A). Only cis-nerolidol (C-NER) demonstrated cytotoxicity (100 to 250 μM) activity and was selected to conduct the following experiments...
March 2, 2017: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28224059/identification-of-downy-mildew-resistance-gene-candidates-by-positional-cloning-in-maize-zea-mays-subsp-mays-poaceae
#16
Jae Yoon Kim, Jun-Cheol Moon, Hyo Chul Kim, Seungho Shin, Kitae Song, Kyung-Hee Kim, Byung-Moo Lee
PREMISE OF THE STUDY: Positional cloning in combination with phenotyping is a general approach to identify disease-resistance gene candidates in plants; however, it requires several time-consuming steps including population or fine mapping. Therefore, in the present study, we suggest a new combined strategy to improve the identification of disease-resistance gene candidates. METHODS AND RESULTS: Downy mildew (DM)-resistant maize was selected from five cultivars using a spreader row technique...
February 2017: Applications in Plant Sciences
https://www.readbyqxmd.com/read/28215535/ambra1-a-novel-bh3-like-protein-new-insights-into-the-ambra1-bcl2-family-proteins-relationship
#17
A Di Rita, F Strappazzon
Cellular homeostasis swings like a pendulum backward and forward between life and death. Two of the main processes, which regulate this equilibrium, are autophagy and apoptosis. While autophagy is a highly conserved self-digestion mechanism that mediates degradation of damaged or surplus components, apoptosis is a programmed cell suicide in which typical death signals induce the elimination of undesired cells. Both these processes are highly regulated by complex molecular machineries, including some common proteins whose "dual role" favors one process or the other...
2017: International Review of Cell and Molecular Biology
https://www.readbyqxmd.com/read/28213497/mitochondrial-damage-elicits-a-tcdd-inducible-poly-adp-ribose-polymerase-mediated-antiviral-response
#18
Tatsuya Kozaki, Jun Komano, Daiki Kanbayashi, Michihiro Takahama, Takuma Misawa, Takashi Satoh, Osamu Takeuchi, Taro Kawai, Shigeomi Shimizu, Yoshiharu Matsuura, Shizuo Akira, Tatsuya Saitoh
The innate immune system senses RNA viruses by pattern recognition receptors (PRRs) and protects the host from virus infection. PRRs mediate the production of immune modulatory factors and direct the elimination of RNA viruses. Here, we show a unique PRR that mediates antiviral response. Tetrachlorodibenzo-p-dioxin (TCDD)-inducible poly(ADP ribose) polymerase (TIPARP), a Cysteine3 Histidine (CCCH)-type zinc finger-containing protein, binds to Sindbis virus (SINV) RNA via its zinc finger domain and recruits an exosome to induce viral RNA degradation...
March 7, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28205292/verticillium-dahliae-manipulates-plant-immunity-by-glycoside-hydrolase-12-proteins-in-conjunction-with-carbohydrate-binding-module-1
#19
Yue-Jing Gui, Jie-Yin Chen, Dan-Dan Zhang, Nan-Yang Li, Ting-Gang Li, Wen-Qi Zhang, Xin-Yan Wang, Dylan P G Short, Lei Li, Wei Guo, Zhi-Qiang Kong, Yu-Ming Bao, Krishna V Subbarao, Xiao-Feng Dai
Glycoside hydrolase 12 (GH12) proteins act as virulence factors and pathogen-associated molecular patterns (PAMPs) in oomycetes. However, the pathogenic mechanisms of fungal GH12 proteins have not been characterized. In this study, we demonstrated that two of the six GH12 proteins produced by the fungus Verticillium dahliae Vd991, VdEG1 and VdEG3 acted as PAMPs to trigger cell death and PAMP-triggered immunity (PTI) independent of their enzymatic activity in Nicotiana benthamiana. A 63-amino-acid peptide of VdEG3 was sufficient for cell death-inducing activity, but this was not the case for the corresponding peptide of VdEG1...
February 15, 2017: Environmental Microbiology
https://www.readbyqxmd.com/read/28187200/ligand-induced-dynamics-of-heterotrimeric-g-protein-coupled-receptor-like-kinase-complexes
#20
Meral Tunc-Ozdemir, Alan M Jones
BACKGROUND: Arabidopsis, 7-transmembrane Regulator of G signaling protein 1 (AtRGS1) modulates canonical G protein signaling by promoting the inactive state of heterotrimeric G protein complex on the plasma membrane. It is known that plant leucine-rich repeat receptor-like kinases (LRR RLKs) phosphorylate AtRGS1 in vitro but little is known about the in vivo interaction, molecular dynamics, or the cellular consequences of this interaction. METHODS: Therefore, a subset of the known RLKs that phosphorylate AtRGS1 were selected for elucidation, namely, BAK1, BIR1, FLS2...
2017: PloS One
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