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https://www.readbyqxmd.com/read/28224059/identification-of-downy-mildew-resistance-gene-candidates-by-positional-cloning-in-maize-zea-mays-subsp-mays-poaceae
#1
Jae Yoon Kim, Jun-Cheol Moon, Hyo Chul Kim, Seungho Shin, Kitae Song, Kyung-Hee Kim, Byung-Moo Lee
PREMISE OF THE STUDY: Positional cloning in combination with phenotyping is a general approach to identify disease-resistance gene candidates in plants; however, it requires several time-consuming steps including population or fine mapping. Therefore, in the present study, we suggest a new combined strategy to improve the identification of disease-resistance gene candidates. METHODS AND RESULTS: Downy mildew (DM)-resistant maize was selected from five cultivars using a spreader row technique...
February 2017: Applications in Plant Sciences
https://www.readbyqxmd.com/read/28215535/ambra1-a-novel-bh3-like-protein-new-insights-into-the-ambra1-bcl2-family-proteins-relationship
#2
A Di Rita, F Strappazzon
Cellular homeostasis swings like a pendulum backward and forward between life and death. Two of the main processes, which regulate this equilibrium, are autophagy and apoptosis. While autophagy is a highly conserved self-digestion mechanism that mediates degradation of damaged or surplus components, apoptosis is a programmed cell suicide in which typical death signals induce the elimination of undesired cells. Both these processes are highly regulated by complex molecular machineries, including some common proteins whose "dual role" favors one process or the other...
2017: International Review of Cell and Molecular Biology
https://www.readbyqxmd.com/read/28213497/mitochondrial-damage-elicits-a-tcdd-inducible-poly-adp-ribose-polymerase-mediated-antiviral-response
#3
Tatsuya Kozaki, Jun Komano, Daiki Kanbayashi, Michihiro Takahama, Takuma Misawa, Takashi Satoh, Osamu Takeuchi, Taro Kawai, Shigeomi Shimizu, Yoshiharu Matsuura, Shizuo Akira, Tatsuya Saitoh
The innate immune system senses RNA viruses by pattern recognition receptors (PRRs) and protects the host from virus infection. PRRs mediate the production of immune modulatory factors and direct the elimination of RNA viruses. Here, we show a unique PRR that mediates antiviral response. Tetrachlorodibenzo-p-dioxin (TCDD)-inducible poly(ADP ribose) polymerase (TIPARP), a Cysteine3 Histidine (CCCH)-type zinc finger-containing protein, binds to Sindbis virus (SINV) RNA via its zinc finger domain and recruits an exosome to induce viral RNA degradation...
February 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28205292/verticillium-dahliae-manipulates-plant-immunity-by-glycoside-hydrolase-12-proteins-in-conjuction-with-carbohydrate-binding-module-1
#4
Yue-Jing Gui, Jie-Yin Chen, Dan-Dan Zhang, Nan-Yang Li, Ting-Gang Li, Wen-Qi Zhang, Xin-Yan Wang, Dylan P G Short, Lei Li, Wei Guo, Zhi-Qiang Kong, Yu-Ming Bao, Krishna V Subbarao, Xiao-Feng Dai
Glycoside hydrolase 12 (GH12) proteins act as virulence factors and pathogen-associated molecular patterns (PAMPs) in oomycetes. However, the pathogenic mechanisms of fungal GH12 proteins have not been characterized. In this study, we demonstrated that two of the six GH12 proteins produced by the fungus Verticillium dahliae Vd991, VdEG1 and VdEG3 acted as PAMPs to trigger cell death and PAMP-triggered immunity (PTI) independent of their enzymatic activity in Nicotiana benthamiana. A 63-amino-acid peptide of VdEG3 was sufficient for cell death-inducing activity, but this was not the case for the corresponding peptide of VdEG1...
February 15, 2017: Environmental Microbiology
https://www.readbyqxmd.com/read/28187200/ligand-induced-dynamics-of-heterotrimeric-g-protein-coupled-receptor-like-kinase-complexes
#5
Meral Tunc-Ozdemir, Alan M Jones
BACKGROUND: Arabidopsis, 7-transmembrane Regulator of G signaling protein 1 (AtRGS1) modulates canonical G protein signaling by promoting the inactive state of heterotrimeric G protein complex on the plasma membrane. It is known that plant leucine-rich repeat receptor-like kinases (LRR RLKs) phosphorylate AtRGS1 in vitro but little is known about the in vivo interaction, molecular dynamics, or the cellular consequences of this interaction. METHODS: Therefore, a subset of the known RLKs that phosphorylate AtRGS1 were selected for elucidation, namely, BAK1, BIR1, FLS2...
2017: PloS One
https://www.readbyqxmd.com/read/28153720/overexpression-of-bak1-causes-salicylic-acid-accumulation-and-deregulation-of-cell-death-control-genes
#6
Sun Young Kim, Yun Shang, Se-Hwan Joo, Seong-Ki Kim, Kyoung Hee Nam
Since the BRI1-Associated Receptor Kinase 1 (BAK1) was firstly identified as a co-receptor of BRI1 that mediates brassinosteroids (BR) signaling, the functional roles of BAK1, as a versatile co-receptor for various ligand-binding leucine-rich repeat (LRR)-containing receptor-like kinase (RLKs), are being extended to involvement with plant immunity, cell death, stomatal development and ABA signaling in plants. During more than a decade of research on the BAK1, it has been known that transgenic Arabidopsis plants overexpressing BAK1 tagged with various reporters do not fully represent its natural functions...
January 31, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28140520/microrna-125a-promotes-resistance-to-braf-inhibitors-through-suppression-of-the-intrinsic-apoptotic-pathway
#7
Lisa Koetz-Ploch, Douglas Hanniford, Igor Dolgalev, Elena Sokolova, Judy Zhong, Marta Díaz-Martínez, Emily Bernstein, Farbod Darvishian, Keith T Flaherty, Paul B Chapman, Hussein Tawbi, Eva Hernando
Melanoma patients with BRAF(V)(600E) -mutant tumors display striking responses to BRAF inhibitors (BRAFi); however, almost all invariably relapse with drug-resistant disease. Here we report that microRNA-125a (miR-125a) expression is upregulated in human melanoma cells and patient tissues upon acquisition of BRAFi resistance. We show that miR-125a induction confers resistance to BRAF(V)(600E) melanoma cells to BRAFi by directly suppressing pro-apoptotic components of the intrinsic apoptosis pathway, including BAK1 and MLK3...
January 31, 2017: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/28124252/identification-of-brassinosteroid-signaling-complexes-by-coimmunoprecipitation-and-mass-spectrometry
#8
Walter van Dongen, Luc van Heerde, Sjef Boeren, Sacco C de Vries
A combination of coimmunoprecipitation (coIP) of tagged proteins followed by protein identification and quantitation using Liquid Chromatography Mass Spectrometry/Mass Spectrometry (LCMS/MS) has proven to be a reliable method to qualitatively characterize membrane-bound receptor complexes from plants. Success depends on a range of parameters, such as abundance and stability of the complex and functionality of the tagged receptors, efficiency of the protein complex isolation procedure, MS equipment, and analysis software in use...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28114413/visualization-of-bri1-and-serk3-bak1-nanoclusters-in-arabidopsis-roots
#9
Stefan J Hutten, Danny S Hamers, Marije Aan den Toorn, Wilma van Esse, Antsje Nolles, Christoph A Bücherl, Sacco C de Vries, Johannes Hohlbein, Jan Willem Borst
Brassinosteroids (BRs) are plant hormones that are perceived at the plasma membrane (PM) by the ligand binding receptor BRASSINOSTEROID-INSENSITIVE1 (BRI1) and the co-receptor SOMATIC EMBRYOGENESIS RECEPTOR LIKE KINASE 3/BRI1 ASSOCIATED KINASE 1 (SERK3/BAK1). To visualize BRI1-GFP and SERK3/BAK1-mCherry in the plane of the PM, variable-angle epifluorescence microscopy (VAEM) was employed, which allows selective illumination of a thin surface layer. VAEM revealed an inhomogeneous distribution of BRI1-GFP and SERK3/BAK1-mCherry at the PM, which we attribute to the presence of distinct nanoclusters...
2017: PloS One
https://www.readbyqxmd.com/read/28104890/the-receptor-kinase-fer-is-a-ralf-regulated-scaffold-controlling-plant-immune-signaling
#10
Martin Stegmann, Jacqueline Monaghan, Elwira Smakowska-Luzan, Hanna Rovenich, Anita Lehner, Nicholas Holton, Youssef Belkhadir, Cyril Zipfel
In plants, perception of invading pathogens involves cell-surface immune receptor kinases. Here, we report that the Arabidopsis SITE-1 PROTEASE (S1P) cleaves endogenous RAPID ALKALINIZATION FACTOR (RALF) propeptides to inhibit plant immunity. This inhibition is mediated by the malectin-like receptor kinase FERONIA (FER), which otherwise facilitates the ligand-induced complex formation of the immune receptor kinases EF-TU RECEPTOR (EFR) and FLAGELLIN-SENSING 2 (FLS2) with their co-receptor BRASSINOSTEROID INSENSITIVE 1-ASSOCIATED KINASE 1 (BAK1) to initiate immune signaling...
January 20, 2017: Science
https://www.readbyqxmd.com/read/28064312/-polymorphisms-of-kitlg-spry4-and-bak1-genes-in-patients-with-testicular-germ-cell-tumors-and-individuals-with-infertility-associated-with-azfc-deletion-of-the-y-chromosome
#11
M V Nemtsova, E V Ivkin, O A Simonova, V V Rudenko, V B Chernykh, D S Mikhaylenko, O B Loran
Testicular cancer is the most common form of solid cancer in young men. Testicular cancer is represented by testicular germ cell tumors (TGCTs) derived from embryonic stem cells with different degrees of differentiation in about 95% of cases. The development of these tumors is related to the formation of a pool of male germ cells and gametogenesis. Clinical factors that are predisposed to the development of germ-cell tumors include cryptorchidism and testicular microlithiasis, as well as infertility associated with the gr/gr deletion within the AZFс locus...
November 2016: Molekuliarnaia Biologiia
https://www.readbyqxmd.com/read/27995670/the-tomato-i-gene-for-fusarium-wilt-resistance-encodes-an-atypical-leucine-rich-repeat-receptor-like-protein-whose-function-is-nevertheless-dependent-on-sobir1-and-serk3-bak1
#12
Ann-Maree Catanzariti, Huong T T Do, Pierrick Bru, Mara de Sain, Louise F Thatcher, Martijn Rep, David A Jones
We have identified the tomato I gene for resistance to the Fusarium wilt fungus Fusarium oxysporum f. sp. lycopersici (Fol) and show that it encodes a membrane-anchored leucine-rich repeat receptor-like protein (LRR-RLP). Unlike most other LRR-RLP genes involved in plant defence, the I gene is not a member of a gene cluster and contains introns in its coding sequence. The I gene encodes a loopout domain larger than those in most other LRR-RLPs with a distinct composition rich in serine and threonine residues...
December 20, 2016: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/27898717/gene-based-genome-wide-association-analysis-in-european-and-asian-populations-identified-novel-genes-for-rheumatoid-arthritis
#13
Hong Zhu, Wei Xia, Xing-Bo Mo, Xiang Lin, Ying-Hua Qiu, Neng-Jun Yi, Yong-Hong Zhang, Fei-Yan Deng, Shu-Feng Lei
OBJECTIVE: Rheumatoid arthritis (RA) is a complex autoimmune disease. Using a gene-based association research strategy, the present study aims to detect unknown susceptibility to RA and to address the ethnic differences in genetic susceptibility to RA between European and Asian populations. METHODS: Gene-based association analyses were performed with KGG 2.5 by using publicly available large RA datasets (14,361 RA cases and 43,923 controls of European subjects, 4,873 RA cases and 17,642 controls of Asian Subjects)...
2016: PloS One
https://www.readbyqxmd.com/read/27884939/regulation-of-sugar-transporter-activity-for-antibacterial-defense-in-arabidopsis
#14
Kohji Yamada, Yusuke Saijo, Hirofumi Nakagami, Yoshitaka Takano
Microbial pathogens strategically acquire metabolites from their hosts during infection. Here we show that the host can intervene to prevent such metabolite loss to pathogens. Phosphorylation-dependent regulation of sugar transport protein 13 (STP13) is required for antibacterial defense in the plant Arabidopsis thaliana STP13 physically associates with the flagellin receptor flagellin-sensitive 2 (FLS2) and its co-receptor BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1 (BAK1). BAK1 phosphorylates STP13 at threonine 485, which enhances its monosaccharide uptake activity to compete with bacteria for extracellular sugars...
December 16, 2016: Science
https://www.readbyqxmd.com/read/27852951/a-cysteine-rich-protein-kinase-associates-with-a-membrane-immune-complex-and-the-cysteine-residues-are-required-for-cell-death
#15
Koste A Yadeta, James M Elmore, Athena Y Creer, Baomin Feng, Jessica Y Franco, Jose Sebastian Rufian, Ping He, Brett Phinney, Gitta Coaker
Membrane-localized proteins perceive and respond to biotic and abiotic stresses. We performed quantitative proteomics on plasma membrane-enriched samples from Arabidopsis (Arabidopsis thaliana) treated with bacterial flagellin. We identified multiple receptor-like protein kinases changing in abundance, including cysteine (Cys)-rich receptor-like kinases (CRKs) that are up-regulated upon the perception of flagellin. CRKs possess extracellular Cys-rich domains and constitute a gene family consisting of 46 members in Arabidopsis...
January 2017: Plant Physiology
https://www.readbyqxmd.com/read/27821806/investigation-on-tissue-specific-effects-of-pro-apoptotic-micro-rnas-revealed-mir-147b-as-a-potential-biomarker-in-ovarian-cancer-prognosis
#16
Michael Kleemann, Jeremias Bereuther, Simon Fischer, Kim Marquart, Simon Hänle, Kristian Unger, Verena Jendrossek, Christian U Riedel, René Handrick, Kerstin Otte
The development and progression of cancer can be ascribed to imbalances in gene regulation leading to aberrant cellular behavior. The loss of micro RNAs (miRNAs) exhibiting tumor-suppressive function has been demonstrated to be often causative for uncontrolled cell proliferation, migration or tissue infiltration. The installation of de novo tumor suppressive function by using pro-apoptotic miRNAs might be a promising therapeutic approach. In addition, there is a great demand for novel biomarkers for the prognosis of cancer, which prompted us to transfer a high content miRNA screening initially performed to identify bioprocess relevant miRNAs in Chinese hamster ovary (CHO) cells to human cancer cell lines ...
November 4, 2016: Oncotarget
https://www.readbyqxmd.com/read/27791461/looking-bak-again-is-an-old-acquaintance-of-innate-immunity-involved-in-the-detection-of-herbivores
#17
Dominik Klauser, Pascale Flury, Thomas Boller, Sebastian Merker
The membrane-based receptor-like kinase BAK1 has been reported to interact with a number of other membrane-based receptors to contribute to a variety of signaling responses to exogenous and endogenous cues. These include brassinosteroid hormones as well as conserved microbe-derived and endogenous patterns. More recently, several lines of evidence have been reported to expand this concept also to the detection and deterrence of insect herbivores. We hereby present results that further support this hypothesis as they show that in Arabidopsis thaliana, herbivore oral secretions trigger two hallmark responses of plant innate immunity and that these responses are significantly reduced in plants that lack functional BAK1 receptors...
November 2016: Plant Signaling & Behavior
https://www.readbyqxmd.com/read/27755961/marrubium-vulgare-ethanolic-extract-induces-proliferation-block-apoptosis-and-cytoprotective-autophagy-in-cancer-cells-in-vitro
#18
V Paunovic, M Kosic, S Djordjevic, A Zugic, N Djalinac, U Gasic, V Trajkovic, J Harhaji-Trajkovic
Marrubium vulgare is a European medicinal plant with numerous beneficial effects on human health. The aim of the study was to isolate the plant ethanolic extract (MVE) and to investigate its anti-melanoma and anti-glioma effects. MVE was prepared by the modified pharmacopoeial percolation method and characterized by UHPLC-LTQ OrbiTrap MS. MVE dose-dependently reduced viability of melanoma (B16) and glioma (U251) cells, but not peripheral blood mononuclear cells. It arrested cell cycle in S+G2/M phase, which was associated with the activation of MAP kinase p38 and up-regulation of antiproliferative genes p53, p21 and p27...
September 30, 2016: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/27736646/activation-dependent-destruction-of-a-co-receptor-by-a-pseudomonas-syringae-effector-dampens-plant-immunity
#19
Lei Li, Panya Kim, Liping Yu, Gaihong Cai, She Chen, James R Alfano, Jian-Min Zhou
The Arabidopsis immune receptor FLS2 and co-receptor BAK1 perceive the bacterial flagellin epitope flg22 to activate plant immunity. To prevent this response, phytopathogenic bacteria deploy a repertoire of effector proteins to perturb immune signaling. However, the effector-induced perturbation is often sensed by the host, triggering another layer of immunity. We report that the Pseudomonas syringae effector HopB1 acts as a protease to cleave immune-activated BAK1. Prior to activation, HopB1 constitutively interacts with FLS2...
October 12, 2016: Cell Host & Microbe
https://www.readbyqxmd.com/read/27683819/microrna-125b-prevents-cardiac-dysfunction-in-polymicrobial-sepsis-by-targeting-traf6-mediated-nuclear-factor-%C3%AE%C2%BAb-activation-and-p53-mediated-apoptotic-signaling
#20
He Ma, Xiaohui Wang, Tuanzhu Ha, Ming Gao, Li Liu, Ruitao Wang, Kaijiang Yu, John H Kalbfleisch, Race L Kao, David L Williams, Chuanfu Li
BACKGROUND:  This study examined the effect of microRNA-125b (miR-125b) on sepsis-induced cardiac dysfunction. METHODS:  Mouse hearts were transfected with lentivirus expressing miR-125b (LmiR-125b) 7 days before cecal ligation and puncture (CLP)-induced sepsis. Cardiac function was examined by echocardiography before and 6 hours after CLP (n = 6/group). Survival was monitored following CLP-induced sepsis (n = 12/group). RESULTS:  LmiR-125b transfection significantly attenuated cardiac dysfunction due to CLP-induced sepsis...
December 1, 2016: Journal of Infectious Diseases
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