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https://www.readbyqxmd.com/read/27780848/sucrose-non-fermenting-related-kinase-enzyme-mediated-rho-associated-kinase-signaling-is-responsible-for-cardiac-function
#1
Stephanie M Cossette, Vijesh J Bhute, Xiaoping Bao, Leanne M Harmann, Mark A Horswill, Indranil Sinha, Adam Gastonguay, Shabnam Pooya, Michelle Bordas, Suresh N Kumar, Shama P Mirza, Sean Palecek, Jennifer Strande, Ramani Ramchandran
BACKGROUND: -Cardiac metabolism is critical for the functioning of the heart, and disturbance in this homeostasis is likely to influence cardiac disorders or cardiomyopathy. Our lab has previously shown that sucrose non-fermenting related kinase (SNRK) enzyme, which belongs to the AMP-activated kinase (AMPK) family, was essential for cardiac metabolism in mammals. Snrk global homozygous knockout (KO) mice die at postnatal day 0, and conditional deletion of Snrk in cardiomyocytes (Snrk cmcKO) leads to cardiac failure, and death by 8-10 months...
October 25, 2016: Circulation. Cardiovascular Genetics
https://www.readbyqxmd.com/read/27060495/dissecting-abscisic-acid-signaling-pathways-involved-in-cuticle-formation
#2
Fuqiang Cui, Mikael Brosché, Mikko T Lehtonen, Ali Amiryousefi, Enjun Xu, Matleena Punkkinen, Jari P T Valkonen, Hiroaki Fujii, Kirk Overmyer
The cuticle is the outer physical barrier of aerial plant surfaces and an important interaction point between plants and the environment. Many environmental stresses affect cuticle formation, yet the regulatory pathways involved remain undefined. We used a genetics and gene expression analysis in Arabidopsis thaliana to define an abscisic acid (ABA) signaling loop that positively regulates cuticle formation via the core ABA signaling pathway, including the PYR/PYL receptors, PP2C phosphatase, and SNF1-Related Protein Kinase (SnRK) 2...
June 6, 2016: Molecular Plant
https://www.readbyqxmd.com/read/26089150/genome-wide-analysis-of-snrk-gene-family-in-brachypodium-distachyon-and-functional-characterization-of-bdsnrk2-9
#3
Lianzhe Wang, Wei Hu, Jiutong Sun, Xiaoyu Liang, Xiaoyue Yang, Shuya Wei, Xiatian Wang, Yi Zhou, Qiang Xiao, Guangxiao Yang, Guangyuan He
The sucrose non-fermenting 1 (SNF1)-related protein kinases (SnRKs) play key roles in plant signaling pathways including responses to biotic and abiotic stresses. Although SnRKs have been systematically studied in Arabidopsis and rice, there is no information concerning SnRKs in the new Poaceae model plant Brachypodium distachyon. In the present study, a total of 44 BdSnRKs were identified and classified into three subfamilies, including three members of BdSnRK1, 10 of BdSnRK2 and 31 of BdSnRK3 (CIPK) subfamilies...
August 2015: Plant Science: An International Journal of Experimental Plant Biology
https://www.readbyqxmd.com/read/25527104/g-quadruplex-g4-motifs-in-the-maize-zea-mays-l-genome-are-enriched-at-specific-locations-in-thousands-of-genes-coupled-to-energy-status-hypoxia-low-sugar-and-nutrient-deprivation
#4
Carson M Andorf, Mykhailo Kopylov, Drena Dobbs, Karen E Koch, M Elizabeth Stroupe, Carolyn J Lawrence, Hank W Bass
The G-quadruplex (G4) elements comprise a class of nucleic acid structures formed by stacking of guanine base quartets in a quadruple helix. This G4 DNA can form within or across single-stranded DNA molecules and is mutually exclusive with duplex B-form DNA. The reversibility and structural diversity of G4s make them highly versatile genetic structures, as demonstrated by their roles in various functions including telomere metabolism, genome maintenance, immunoglobulin gene diversification, transcription, and translation...
December 20, 2014: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/25505152/sucrose-non-fermenting-related-kinase-enzyme-is-essential-for-cardiac-metabolism
#5
Stephanie M Cossette, Adam J Gastonguay, Xiaoping Bao, Alexandra Lerch-Gaggl, Ling Zhong, Leanne M Harmann, Christopher Koceja, Robert Q Miao, Padmanabhan Vakeel, Changzoon Chun, Keguo Li, Jamie Foeckler, Michelle Bordas, Hartmut Weiler, Jennifer Strande, Sean P Palecek, Ramani Ramchandran
In this study, we have identified a novel member of the AMPK family, namely Sucrose non-fermenting related kinase (Snrk), that is responsible for maintaining cardiac metabolism in mammals. SNRK is expressed in the heart, and brain, and in cell types such as endothelial cells, smooth muscle cells and cardiomyocytes (CMs). Snrk knockout (KO) mice display enlarged hearts, and die at postnatal day 0. Microarray analysis of embryonic day 17.5 Snrk hearts, and blood profile of neonates display defect in lipid metabolic pathways...
2014: Biology Open
https://www.readbyqxmd.com/read/25244018/recent-progress-on-liver-kinase-b1-lkb1-expression-regulation-downstream-signaling-and-cancer-suppressive-function
#6
Ren-You Gan, Hua-Bin Li
Liver kinase B1 (LKB1), known as a serine/threonine kinase, has been identified as a critical cancer suppressor in many cancer cells. It is a master upstream kinase of 13 AMP-activated protein kinase (AMPK)-related protein kinases, and possesses versatile biological functions. LKB1 gene is mutated in many cancers, and its protein can form different protein complexes with different cellular localizations in various cell types. The expression of LKB1 can be regulated through epigenetic modification, transcriptional regulation and post-translational modification...
2014: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/25058458/arabidopsis-cipk14-positively-regulates-glucose-response
#7
Jingli Yan, Fangfang Niu, Wu-Zhen Liu, Hanfeng Zhang, Boya Wang, Wenzhi Lan, Yufen Che, Bo Yang, Sheng Luan, Yuan-Qing Jiang
Calcium is a ubiquitous intracellular secondary messenger in plants. Calcineurin B-like proteins (CBLs), which contain four Ca(2+)-binding EF hand motifs, are Ca(2+) sensors and regulate a group of Ser/Thr protein kinases called CBL-interacting protein kinases (CIPKs). Although the CBL-CIPK network has been demonstrated to play crucial roles in plant development and responses to various environmental stresses in Arabidopsis, little is known about their function in glucose signaling. In the present study, we identified CIPK14 gene from Arabidopsis that play a role in glucose signaling...
August 8, 2014: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/24091291/the-role-of-aba-and-mapk-signaling-pathways-in-plant-abiotic-stress-responses
#8
REVIEW
Agyemang Danquah, Axel de Zelicourt, Jean Colcombet, Heribert Hirt
As sessile organisms, plants have developed specific mechanisms that allow them to rapidly perceive and respond to stresses in the environment. Among the evolutionarily conserved pathways, the ABA (abscisic acid) signaling pathway has been identified as a central regulator of abiotic stress response in plants, triggering major changes in gene expression and adaptive physiological responses. ABA induces protein kinases of the SnRK family to mediate a number of its responses. Recently, MAPK (mitogen activated protein kinase) cascades have also been shown to be implicated in ABA signaling...
January 2014: Biotechnology Advances
https://www.readbyqxmd.com/read/23914195/regulation-of-fruit-and-seed-response-to-heat-and-drought-by-sugars-as-nutrients-and-signals
#9
Yong-Hua Liu, Christina E Offler, Yong-Ling Ruan
A large body of evidence shows that sugars function both as nutrients and signals to regulate fruit and seed set under normal and stress conditions including heat and drought. Inadequate sucrose import to, and its degradation within, reproductive organs cause fruit and seed abortion under heat and drought. As nutrients, sucrose-derived hexoses provide carbon skeletons and energy for growth and development of fruits and seeds. Sugar metabolism can also alleviate the impact of stress on fruit and seed through facilitating biosynthesis of heat shock proteins (Hsps) and non-enzymic antioxidants (e...
2013: Frontiers in Plant Science
https://www.readbyqxmd.com/read/23520131/identification-of-sucrose-non-fermenting-related-kinase-snrk-as-a-suppressor-of-adipocyte-inflammation
#10
Yujie Li, Yaohui Nie, Ynes Helou, Guoxian Ding, Bin Feng, Gang Xu, Arthur Salomon, Haiyan Xu
In this study, the role of sucrose non-fermenting-related kinase (SNRK) in white adipocyte biology was investigated. SNRK is abundantly expressed in adipose tissue, and the expression level is decreased in obese mice. SNRK expression is repressed by inflammatory signals but increased by insulin sensitizer in cultured adipocytes. In vivo, adipose tissue SNRK expression can be decreased by lipid injection but enhanced by macrophage ablation. Knocking down SNRK in cultured adipocytes activates both JNK and IKKβ pathways as well as promotes lipolysis...
July 2013: Diabetes
https://www.readbyqxmd.com/read/23307919/the-inhibitory-effect-of-aba-on-floral-transition-is-mediated-by-abi5-in-arabidopsis
#11
Yanping Wang, Lin Li, Tiantian Ye, Yuming Lu, Xi Chen, Yan Wu
Seed germination and flowering initiation are both transitions responding to similar seasonal cues. This study shows that ABSCISIC ACID-INSENSITIVE MUTANT 5 (ABI5), a bZIP transcription factor, which plays an important role in the abscisic acid (ABA)-arrested seed germination, is robustly associated with the floral transition in Arabidopsis. Under long-day conditions, overexpression of ABI5 could delay floral transition through upregulating FLOWERING LOCUS C (FLC) expression. In contrast, ectopically overexpressing FLC in an abi5 mutant reversed the earlier flowering phenotype...
January 2013: Journal of Experimental Botany
https://www.readbyqxmd.com/read/23007729/direct-interactions-of-aba-insensitive-abi-clade-protein-phosphatase-pp-2cs-with-calcium-dependent-protein-kinases-and-aba-response-element-binding-bzips-may-contribute-to-turning-off-aba-response
#12
Tim Lynch, B Joy Erickson, Ruth R Finkelstein
Abscisic acid (ABA) signaling via the pyrabactin-resistant and related (PYR/PYL/RCAR) receptors begins with ABA-dependent inactivation of the ABA-insensitive(ABI)-clade protein phosphatases(PP)2Cs, thereby permitting phosphorylation and activation of the Snf1-related (SnRK)2 clade of protein kinases, and activation of their downstream targets such as ABA-response element binding basic leucine zipper (bZIP) transcription factors (ABF/AREB/ABI5 clade). Several of these are also activated by calcium-dependent protein kinases such as CPK11...
December 2012: Plant Molecular Biology
https://www.readbyqxmd.com/read/22967043/controlled-nuclear-import-of-the-transcription-factor-ntl6-reveals-a-cytoplasmic-role-of-snrk2-8-in-the-drought-stress-response
#13
Mi Jung Kim, Mi-Jeong Park, Pil Joon Seo, Jin-Su Song, Hie-Joon Kim, Chung-Mo Park
Controlled proteolytic activation of membrane-anchored transcription factors provides an adaptation strategy that guarantees rapid transcriptional responses to abrupt environmental stresses in both animals and plants. NTL6 is a plant-specific NAC [NAM/ATAF1/2/CUC2] transcription factor that is expressed as a dormant plasma membrane-associated form in Arabidopsis. Proteolytic processing of NTL6 is triggered by abiotic stresses and ABA (abscisic acid). In the present study, we show that NTL6 is linked directly with SnRK (Snf1-related protein kinase) 2...
December 15, 2012: Biochemical Journal
https://www.readbyqxmd.com/read/22874833/snf1-related-kinase-inhibits-colon-cancer-cell-proliferation-through-calcyclin-binding-protein-dependent-reduction-of-%C3%AE-catenin
#14
Amy K Rines, Michael A Burke, Richard P Fernandez, Olga V Volpert, Hossein Ardehali
Sucrose nonfermenting 1 (Snf1)-related kinase (SNRK) is a serine/threonine kinase with sequence similarity to AMP-activated protein kinase (AMPK); however, its function is not well characterized. We conducted a gene array to determine which genes are regulated by SNRK. The array demonstrated that SNRK overexpression increased the levels of genes involved in cell proliferation, including calcyclin-binding protein (CacyBP), a member of the ubiquitin ligase complex that targets nonphosphorylated β-catenin for degradation...
November 2012: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/22828864/osmotic-stress-signaling-via-protein-kinases
#15
REVIEW
Hiroaki Fujii, Jian-Kang Zhu
Plants face various kinds of environmental stresses, including drought, salinity, and low temperature, which cause osmotic stress. An understanding of the plant signaling pathways that respond to osmotic stress is important for both basic biology and agriculture. In this review, we summarize recent investigations concerning the SNF1-related protein kinase (SnRK) 2 kinase family, which play central roles in osmotic stress responses. SnRK2s are activated by osmotic stress, and a mutant lacking SnRK2s is hypersensitive to osmotic stress...
October 2012: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/22439004/gsapk-an-aba-activated-and-calcium-independent-snrk2-type-kinase-from-g-soja-mediates-the-regulation-of-plant-tolerance-to-salinity-and-aba-stress
#16
Liang Yang, Wei Ji, Peng Gao, Yong Li, Hua Cai, Xi Bai, Qin Chen, Yanming Zhu
Plant Snf1 (sucrose non-fermenting-1) related protein kinase (SnRK), a subfamily of serine/threonine kinases, has been implicated as a crucial upstream regulator of ABA and osmotic signaling as in many other signaling cascades. In this paper, we have isolated a novel plant specific ABA activated calcium independent protein kinase (GsAPK) from a highly salt tolerant plant, Glycine soja (50109), which is a member of the SnRK2 family. Subcellular localization studies using GFP fusion protein indicated that GsAPK is localized in the plasma membrane...
2012: PloS One
https://www.readbyqxmd.com/read/22128331/dormancy-cycling-in-arabidopsis-seeds-is-controlled-by-seasonally-distinct-hormone-signaling-pathways
#17
Steven Footitt, Isabel Douterelo-Soler, Heather Clay, William E Finch-Savage
Seeds respond to environmental signals, tuning their dormancy cycles to the seasons and thereby determining the optimum time for plant establishment. The molecular regulation of dormancy cycling is unknown, but an extensive range of mechanisms have been identified in laboratory experiments. Using a targeted investigation of gene expression over the dormancy cycle of Arabidopsis seeds in the field, we investigated how these mechanisms are seasonally coordinated. Depth of dormancy and gene expression patterns were correlated with seasonal changes in soil temperature...
December 13, 2011: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/21994172/evidence-that-abscisic-acid-promotes-degradation-of-snf1-related-protein-kinase-snrk-1-in-wheat-and-activation-of-a-putative-calcium-dependent-snrk2
#18
Patricia Coello, Emi Hirano, Sandra J Hey, Nira Muttucumaru, Eleazar Martinez-Barajas, Martin A J Parry, Nigel G Halford
Sucrose nonfermenting-1 (SNF1)-related protein kinases (SnRKs) form a major family of signalling proteins in plants and have been associated with metabolic regulation and stress responses. They comprise three subfamilies: SnRK1, SnRK2, and SnRK3. SnRK1 plays a major role in the regulation of carbon metabolism and energy status, while SnRKs 2 and 3 have been implicated in stress and abscisic acid (ABA)-mediated signalling pathways. The burgeoning and divergence of this family of protein kinases in plants may have occurred to enable cross-talk between metabolic and stress signalling, and ABA-response-element-binding proteins (AREBPs), a family of transcription factors, have been shown to be substrates for members of all three subfamilies...
January 2012: Journal of Experimental Botany
https://www.readbyqxmd.com/read/21983340/the-structure-of-arabidopsis-thaliana-ost1-provides-insights-into-the-kinase-regulation-mechanism-in-response-to-osmotic-stress
#19
Cristina Yunta, Martín Martínez-Ripoll, Jian-Kang Zhu, Armando Albert
SnRK [SNF1 (sucrose non-fermenting-1)-related protein kinase] 2.6 [open stomata 1 (OST1)] is well characterized at molecular and physiological levels to control stomata closure in response to water-deficit stress. OST1 is a member of a family of 10 protein kinases from Arabidopsis thaliana (SnRK2) that integrates abscisic acid (ABA)-dependent and ABA-independent signals to coordinate the cell response to osmotic stress. A subgroup of protein phosphatases type 2C binds OST1 and keeps the kinase dephosphorylated and inactive...
November 18, 2011: Journal of Molecular Biology
https://www.readbyqxmd.com/read/21549957/evolution-of-abscisic-acid-synthesis-and-signaling-mechanisms
#20
REVIEW
Felix Hauser, Rainer Waadt, Julian I Schroeder
The plant hormone abscisic acid (ABA) mediates seed dormancy, controls seedling development and triggers tolerance to abiotic stresses, including drought. Core ABA signaling components consist of a recently identified group of ABA receptor proteins of the PYRABACTIN RESISTANCE (PYR)/REGULATORY COMPONENT OF ABA RECEPTOR (RCAR) family that act as negative regulators of members of the PROTEIN PHOSPHATASE 2C (PP2C) family. Inhibition of PP2C activity enables activation of SNF1-RELATED KINASE 2 (SnRK2) protein kinases, which target downstream components, including transcription factors, ion channels and NADPH oxidases...
May 10, 2011: Current Biology: CB
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