Cristina M Al-Matarneh, Mariana Pinteala, Alina Nicolescu, Mihaela Silion, Francesca Mocci, Razvan Puf, Andrea Angeli, Marta Ferraroni, Claudiu T Supuran, Susi Zara, Simone Carradori, Niccolò Paoletti, Alessandro Bonardi, Paola Gratteri
New dihydro-pyrrol-2-one compounds, featuring dual sulfonamide groups, were synthesized through a one-pot, three-component approach utilizing trifluoroacetic acid as a catalyst. Computational analysis using density functional theory (DFT) and condensed Fukui function explored the structure-reactivity relationship. Evaluation against human carbonic anhydrase isoforms (hCA I, II, IX, XII) revealed potent inhibition. The widely expressed cytosolic hCA I was inhibited across a range of concentrations ( K I 3.9-870...
February 1, 2024: Journal of Medicinal Chemistry