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Luca Palmieri, Filipe Elvas, Christel Vangestel, Koon Pak, Brian Gray, Sigrid Stroobants, Steven Staelens, Leonie Wyffels
INTRODUCTION: [(99m)Tc]duramycin is a SPECT tracer for cell death imaging. We evaluated the impact of kit formulation, purification and species difference on the pharmacokinetic profile and cell death targeting properties of [(99m)Tc]duramycin in order to define the optimal conditions for (pre-)clinical use. METHODS: Three kits were prepared (A: traditional formulation, B: containing 1/3 of ingredients, C: containing HYNIC-PEG12-duramycin). Following labeling, the kits were used without purification, or with SPE or HPLC purification...
September 14, 2017: Nuclear Medicine and Biology
Cody L Shults, Caitlin B Dingwall, Chun K Kim, Elena Pinceti, Yathindar S Rao, Toni R Pak
Alternative RNA splicing results in the translation of diverse protein products arising from a common nucleotide sequence. These alternative protein products are often functional and can have widely divergent actions from the canonical protein. Studies in humans and other vertebrate animals have demonstrated that alternative splicing events increase with advanced age, sometimes resulting in pathological consequences. Menopause represents a critical transition for women, where the beneficial effects of estrogens are no longer evident; therefore, factors underlying increased pathological conditions in women are confounded by the dual factors of aging and declining estrogens...
September 14, 2017: Neurobiology of Aging
Alexey Bezryadin, Andrey Belkin, Eduard Ilin, Michael Pak, Eugene Colla, Alfred Hubler
Electric capacitors are commonly used in electronic circuits for short-term storage of small amounts of energy. It is desirable however to use capacitors to store much larger energy amounts to replace rechargeable batteries. Unfortunately the existing capacitors cannot store a sufficient energy to be able to replace common electrochemical energy storage systems. Here we examine energy storage capabilities of graphene nanocapacitors, which are try-layers involving an Al film, Al2O3 dielectric layer, and a single layer of carbon atoms, i...
October 13, 2017: Nanotechnology
Hao Zheng, Zhe Wang, Wenwei Liu, Hongtao Jin, Jinlan Zhang
Biqi capsule is a well-known traditional Chinese medicine (TCM) formula that has been widely applied for the clinical treatment of such diseases as rheumatoid arthritis, scapulohumeral periarthritis, and cervical spondylopathy. However, there is concern regarding the toxicity of Biqi capsule due to its active ingredients, strychnine and brucine. To investigate the toxicokinetics of strychnine and brucine after the oral administration of Biqi capsule to rats, a sensitive and simple rapid-resolution liquid chromatography/tandem mass spectrometry (RRLC-MS/MS) method was developed to determine the levels of strychnine and brucine in rat plasma...
October 13, 2017: Biomedical Chromatography: BMC
Jung-Woo Lee, Jeong-Ho Cha, Sun-Hee Shin, Yun-Jeong Kim, Seul-Ki Lee, Choon-Keun Park, Kyung-Ah Pak, Ji-Sung Yoon, Seo-Young Park
OBJECTIVE: Delaying embryo transfer (ET) enables us to select among the embryos available for transfer and is associated with positive effects on implantation and pregnancy outcomes. However, the optimal day for ET of human cleavage-stage embryos remains controversial. METHODS: A retrospective study of 3,124 in vitro fertilization/intracytoplasmic sperm injection cycles (2,440 patients) was conducted. We compared the effects of day 2 and 3 ET on rates of implantation and pregnancy outcomes between young maternal age (YMA; <38 years old, n=2,295) and old maternal age (OMA; ≥38 years old, n=829) patient groups...
September 2017: Clinical and Experimental Reproductive Medicine
Jonathan Xinguo Fang, Benjamin Xinhao Fang, Cheung-Chi Simon Lam, Pak-Hei Chan, Frankie Choi-Cheung Tam, Chung-Wah Siu
Right ventricular strain patterns on electrocardiogram such as right axis derivation and S1Q3T3 are well known for their diagnostic value in cases of acute pulmonary embolism. Nonetheless, these changes are not pathognomonic. We report a patient with electrocardiographic evidence of right ventricular strain secondary to an unusual etiology.
October 2017: Clinical Case Reports
Stella Pak, Yan Yatsynovich, John-Phillip Markovic
AIMS: The goal was to compare the size of myocardial infarct detected on CMRI between patients with and without admission hyperglycemia after acute myocardial infarction. METHODS: Studies were located from database searching on MEDLINE, EMBASE, and CINAHL. Systematic review was conducted by two independent reviewers. Microvascular obstruction and late gadolinium enhancement were pooled from available studies to calculate the standardized mean difference (SMD) in post-MI infarct size between patients with and without hyperglycemia in admission...
October 9, 2017: Hellenic Journal of Cardiology: HJC, Hellēnikē Kardiologikē Epitheōrēsē
Ewelina Jurewicz, Elżbieta Wyroba, Anna Filipek
S100A6 is a calcium binding protein expressed mainly in fibroblasts and epithelial cells. Interestingly, S100A6 is also present in extracellular fluids. Recently we have shown that S100A6 is secreted by WJMS cells and binds to integrin β1 (Jurewicz et al., 2014). In this work we describe for the first time the mechanism of S100A6 secretion and signaling pathways activated by the S100A6-integrin β1 complex. We show that colchicine suppressed the release of S100A6 into the cell medium, which indicates that the protein might be secreted via a tubulin-dependent pathway...
October 8, 2017: Cellular Signalling
Jae-Sun Uhm, Nam Kyun Kim, Hee Tae Yu, Pil-Sung Yang, Jung Ok Kim, Tae-Hoon Kim, Mi Kyoung Song, Sang-Yun Lee, Boyoung Joung, Hui-Nam Pak, Jae Young Choi, Jo Won Jung, Moon-Hyoung Lee
Aims: In patients with Fontan circulation, the conduit may be punctured for electrophysiological procedures. We evaluated the feasibility and safety of a stepwise approach to conduit puncture in adults who have undergone Fontan operation. Methods and results: We included 13 consecutive patients with lateral tunnel or extracardiac conduit Fontan circulation [median age (interquartile range), 24.0 (16.0-25.0) years; seven men] who had undergone electrophysiological procedures...
June 14, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
Tae-Hoon Kim, Jihei Sara Lee, Jae-Sun Uhm, Boyoung Joung, Moon-Hyoung Lee, Hui-Nam Pak
Aims: Circulating adiponectin is known to have anti-diabetic, anti-atherogenic, and anti-inflammatory properties. However, the predictive value of adiponectin in cardiovascular disease has been reported to be contradictory ('adiponectin paradox') and its relationship with atrial fibrillation (AF) is controversial. We hypothesized that pre-procedural plasma level of adiponectin would have prognostic value in patients who underwent AF catheter ablation. Methods and results: This observational cohort study included 874 patients with paroxysmal AF (PAF) (73...
July 12, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
Nazma Habib Khan, Martin S Llewellyn, Gabriele Schönian, Colin J Sutherland
Leishmania tropica is the causative agent of cutaneous leishmaniasis in Pakistan. Here, intraspecific diversity of L. tropica from northern Pakistan was investigated using multilocus microsatellite typing. Fourteen polymorphic microsatellite markers were typed in 34 recently collected L. tropica isolates from Pakistan along with 158 archival strains of diverse Afro-Eurasian origins. Previously published profiles for 145 strains of L. tropica originating from different regions of Africa, Central Asia, Iran, and Middle East were included for comparison...
September 25, 2017: American Journal of Tropical Medicine and Hygiene
Jae-Keun Kim, Younggul Song, Tae-Young Kim, Kyungjune Cho, Jinsu Pak, Yuri Barbara Choi, Jiwon Shin, Seungjun Chung, Takhee Lee
Grain boundaries in a chemical vapor deposition (CVD)-grown monolayer of MoS2 induce significant effects on the electrical and low frequency noise characteristics of the MoS2. Here, we investigated the electrical properties and noise characteristics of MoS2 field effect transistors (FETs) made with CVD-grown monolayer MoS2. The electrical and noise characteristics of MoS2 FETs were analysed and compared for the MoS2 channel layers with and without grain boundaries. The grain boundary in the CVD-grown MoS2 FETs can be the dominant noise source, and dependence of the extracted Hooge parameters on the gate voltage indicated the domination of the correlated number-mobility fluctuation at the grain boundaries...
October 10, 2017: Nanotechnology
Akihiro Fujikawa, Jeremy Pak Hong Chow, Masahito Matsumoto, Ryoko Suzuki, Kazuya Kuboyama, Naoki Yamamoto, Masaharu Noda
Protein tyrosine phosphatase receptor type Z (PTPRZ, also known as PTPζ or RPTPβ) is preferentially expressed in the central nervous system (CNS). PTPRZ plays important roles during development and adulthood in CNS myelination, learning and memory. Three splicing isoforms for PTPRZ have been identified to date: two receptor type isoforms, PTPRZ-A and PTPRZ-B, and one secretory isoform, PTPRZ-S. We herein identified novel PTPRZ receptor sub-isoforms without a seven-amino acid sequence encoded by exon 16. This sequence forms a part of the helix-turn-helix segment called the 'wedge' structure, which is located at the N-terminal region in the membrane-proximal protein tyrosine phosphatase domain...
June 20, 2017: Journal of Biochemistry
Clara Wing-Yee Wong, Pak-Cheong Ho
No abstract text is available yet for this article.
November 2017: Hand Clinics
Clara Wing-Yee Wong, Pak-Cheong Ho
The thumb carpometacarpal joint (CMCJ1) is born to have good freedom of motion. However, the excellent mobility at this joint also predisposes attenuation of capsuloligamentous structures, joint incongruity, instability, and osteoarthritis. The prevalence of radiographic CMCJ1 arthritis is high. There is no single ideal surgery for all stages of CMCJ1 arthritis, and for all kinds of patients. The arthroscopic approach seems to provide a better alternative with rewarding preliminary results. It includes arthroscopic synovectomy/debridement/thermal shrinkage, arthroscopic partial trapeziectomy and suture button suspensionplasty, and arthroscopic CMCJ1 excision/suture button suspensionplasty/K-wire fixation...
November 2017: Hand Clinics
Pak-Cheong Ho, Wing-Lim Tse, Clara Wing-Yee Wong
Focal chondral lesions are a common cause of chronic wrist pain, with no ideal treatment. The authors developed arthroscopic transplantation of osteochondral autograft from lateral femoral condyle to distal radius with satisfactory outcome in 4 consecutive patients between December 2006 and December 2010. In all cases, graft incorporation was completed by 3 months to 4 months postoperation. All patients showed improvement in wrist function with no pain at follow-up at an average of 70.5 months (range 24-116 months)...
November 2017: Hand Clinics
Michael Chu-Kay Mak, Pak-Cheong Ho
Injury of the triangular fibrocartilage complex (TFCC) is a common cause of ulnar-sided wrist pain. Volar and dorsal radioulnar ligaments and their foveal insertion are the most important stabilizing components of the TFCC. In irreparable tears, anatomic reconstruction of the TFCC aims to restore normal biomechanics and stability of the distal radioulnar joint. We proposed a novel arthroscopic-assisted technique using a palmaris longus tendon graft. Arthroscopic-assisted TFCC reconstruction is a safe and effective approach with outcomes comparable to conventional open reconstruction and may result in a better range of motion from minimizing soft tissue dissection and subsequent scarring...
November 2017: Hand Clinics
Siu-Cheong Jeffrey Justin Koo, Pak-Cheong Ho
We had developed the technique of portal site local anaesthesia (PSLA) for wrist arthroscopy. Two percent lidocaine with 1:200,000 epinephrine is injected through a 25G needle to various portal sites. The radiocarpal joint is then distended with saline injection and portal is created with transverse superficial skin incision followed by dilation with curved hemostat. The patient is neither sedated, nor under general or regional anaesthesia. Tourniquet is not routinely used. PSLA can achieve satisfactory comfort level in 88% of our 111 patients without any complication...
November 2017: Hand Clinics
Jie Du, Chi-Man Vong, Chi-Man Pun, Pak-Kin Wong, Weng-Fai Ip
In this paper, a novel imbalance learning method for binary classes is proposed, named as Post-Boosting of classification boundary for Imbalanced data (PBI), which can significantly improve the performance of any trained neural networks (NN) classification boundary. The procedure of PBI simply consists of two steps: an (imbalanced) NN learning method is first applied to produce a classification boundary, which is then adjusted by PBI under the geometric mean (G-mean). For data imbalance, the geometric mean of the accuracies of both minority and majority classes is considered, that is statistically more suitable than the common metric accuracy...
September 14, 2017: Neural Networks: the Official Journal of the International Neural Network Society
(no author information available yet)
PAK signaling drives resistance to BRAF inhibition and dual BRAF/MEK inhibition via distinct mechanisms.
October 6, 2017: Cancer Discovery
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