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https://www.readbyqxmd.com/read/28208005/expression-of-microrna-in-host-cells-infected-with-helicobacter-pylori
#1
Jun-Won Chung, Seok Hoo Jeong, Sun Mi Lee, Jhang Ho Pak, Gin Hyug Lee, Jin-Yong Jeong, Jin-Ho Kim
Background/Aims: MicroRNAs (miRNAs) regulate gene expression. We assess miRNA regulation by Helicobacter pylori infection and elucidate their role in H. pylori-infected gastric epithelial cells. Methods: The relationship between miRNA expression and DNA methylation was examined. Cells were treated with the nuclear factor-kappaB (NF-κB) inhibitor Bay 11-7082 to determine the relationship between miRNA expression and NF-κB signal transduction. Results: In the negative control cells infected with H...
February 17, 2017: Gut and Liver
https://www.readbyqxmd.com/read/28205613/pak4-interacts-with-p85-alpha-implications-for-pancreatic-cancer-cell-migration
#2
Helen King, Kiruthikah Thillai, Andrew Whale, Prabhu Arumugam, Hesham Eldaly, Hemant M Kocher, Claire M Wells
It has been reported that p21-activated kinase 4 (PAK4) is amplified in pancreatic cancer tissue. PAK4 is a member of the PAK family of serine/threonine kinases, which act as effectors for several small GTPases, and has been specifically identified to function downstream of HGF-mediated c-Met activation in a PI3K dependent manner. However, the functionality of PAK4 in pancreatic cancer and the contribution made by HGF signalling to pancreatic cancer cell motility remain to be elucidated. We now find that elevated PAK4 expression is coincident with increased expression levels of c-Met and the p85α subunit of PI3K...
February 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28196052/association-between-tangential-contraction-and-early-vision-loss-in-idiopathic-epiretinal-membrane
#3
Seung Min Lee, Kang Yeun Pak, Han Jo Kwon, Sung Who Park, Ji Eun Lee, Ik Soo Byon
PURPOSE: To investigate the clinical features associated with early visual loss in patients with idiopathic epiretinal membrane. METHODS: Patients with idiopathic epiretinal membrane with visual acuity of ≥20/40, intact ellipsoid zone, and follow-up duration of at least 24 months were included in this retrospective age-matched control study. The disk-fovea-vascular (DFV) distance, central macular thickness, membrane configuration, and ellipsoid zone were assessed using fundus photography and spectral domain optical coherence tomography...
February 10, 2017: Retina
https://www.readbyqxmd.com/read/28193398/incidence-of-invasive-salmonella-disease-in-sub-saharan-africa-a-multicentre-population-based-surveillance-study
#4
Florian Marks, Vera von Kalckreuth, Peter Aaby, Yaw Adu-Sarkodie, Muna Ahmed El Tayeb, Mohammad Ali, Abraham Aseffa, Stephen Baker, Holly M Biggs, Morten Bjerregaard-Andersen, Robert F Breiman, James I Campbell, Leonard Cosmas, John A Crump, Ligia Maria Cruz Espinoza, Jessica Fung Deerin, Denise Myriam Dekker, Barry S Fields, Nagla Gasmelseed, Julian T Hertz, Nguyen Van Minh Hoang, Justin Im, Anna Jaeger, Hyon Jin Jeon, Leon Parfait Kabore, Karen H Keddy, Frank Konings, Ralf Krumkamp, Benedikt Ley, Sandra Valborg Løfberg, Jürgen May, Christian G Meyer, Eric D Mintz, Joel M Montgomery, Aissatou Ahmet Niang, Chelsea Nichols, Beatrice Olack, Gi Deok Pak, Ursula Panzner, Jin Kyung Park, Se Eun Park, Henintsoa Rabezanahary, Raphaël Rakotozandrindrainy, Tiana Mirana Raminosoa, Tsiriniaina Jean Luco Razafindrabe, Emmanuel Sampo, Heidi Schütt-Gerowitt, Amy Gassama Sow, Nimako Sarpong, Hye Jin Seo, Arvinda Sooka, Abdramane Bassiahi Soura, Adama Tall, Mekonnen Teferi, Kamala Thriemer, Michelle R Warren, Biruk Yeshitela, John D Clemens, Thomas F Wierzba
BACKGROUND: Available incidence data for invasive salmonella disease in sub-Saharan Africa are scarce. Standardised, multicountry data are required to better understand the nature and burden of disease in Africa. We aimed to measure the adjusted incidence estimates of typhoid fever and invasive non-typhoidal salmonella (iNTS) disease in sub-Saharan Africa, and the antimicrobial susceptibility profiles of the causative agents. METHODS: We established a systematic, standardised surveillance of blood culture-based febrile illness in 13 African sentinel sites with previous reports of typhoid fever: Burkina Faso (two sites), Ethiopia, Ghana, Guinea-Bissau, Kenya, Madagascar (two sites), Senegal, South Africa, Sudan, and Tanzania (two sites)...
March 2017: Lancet Global Health
https://www.readbyqxmd.com/read/28193203/first-insight-into-the-somatic-mutation-burden-of-neurofibromatosis-type-2-associated-grade-i-and-grade-ii-meningiomas-a-case-report-comprehensive-genomic-study-of-two-cranial-meningiomas-with-vastly-different-clinical-presentation
#5
Ramita Dewan, Alexander Pemov, Amalia S Dutra, Evgenia D Pak, Nancy A Edwards, Abhik Ray-Chaudhury, Nancy F Hansen, Settara C Chandrasekharappa, James C Mullikin, Ashok R Asthagiri, John D Heiss, Douglas R Stewart, Anand V Germanwala
BACKGROUND: Neurofibromatosis type 2 (NF2) is a rare autosomal dominant nervous system tumor predisposition disorder caused by constitutive inactivation of one of the two copies of NF2. Meningiomas affect about one half of NF2 patients, and are associated with a higher disease burden. Currently, the somatic mutation landscape in NF2-associated meningiomas remains largely unexamined. CASE PRESENTATION: Here, we present an in-depth genomic study of benign and atypical meningiomas, both from a single NF2 patient...
February 13, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28184254/npcare-database-of-natural-products-and-fractional-extracts-for-cancer-regulation
#6
Hwanho Choi, Sun Young Cho, Ho Jeong Pak, Youngsoo Kim, Jung-Yun Choi, Yoon Jae Lee, Byung Hee Gong, Yeon Seok Kang, Taehoon Han, Geunbae Choi, Yeeun Cho, Soomin Lee, Dekwoo Ryoo, Hwangseo Park
BACKGROUND: Natural products have increasingly attracted much attention as a valuable resource for the development of anticancer medicines due to the structural novelty and good bioavailability. This necessitates a comprehensive database for the natural products and the fractional extracts whose anticancer activities have been verified. DESCRIPTION: NPCARE (http://silver.sejong.ac.kr/npcare) is a publicly accessible online database of natural products and fractional extracts for cancer regulation...
2017: Journal of Cheminformatics
https://www.readbyqxmd.com/read/28183762/complete-genome-sequence-of-a-velogenic-newcastle-disease-virus-strain-isolated-from-a-clinically-healthy-exotic-parakeet-melopsittacus-undulatus-in-pakistan
#7
Abdul Wajid, Asma Basharat, Taseer Ahmed Khan, Muhammad Wasim, Shafqat Fatima Rehmani
The complete genome sequence of a virulent Newcastle disease virus (vNDV) strain isolated from an exotic parakeet (Melopsittacus undulatus) is described here. The virulent strain parakeet/Pak/R-Pindi/SFR-16/2016 was isolated from a bird reared as a pet in the province of Punjab in the northern region of Pakistan in 2016. Phylogenetic analysis classified the isolate as a member of NDV class II, subgenotype VIIi, in genotype VII.
February 9, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28175305/the-roles-of-protein-disulphide-isomerase-family-a-member-3-erp57-and-surface-thiol-disulphide-exchange-in-human-spermatozoa-zona-pellucida-binding
#8
Chi-Wai Wong, Kevin K W Lam, Cheuk-Lun Lee, William S B Yeung, Wei E Zhao, Pak-Chung Ho, Jian-Ping Ou, Philip C N Chiu
No abstract text is available yet for this article.
February 8, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28174170/does-additional-electrogram-guided-ablation-after-linear-ablation-reduce-recurrence-after-catheter-ablation-for-longstanding-persistent-atrial-fibrillation-a-prospective-randomized-study
#9
Tae-Hoon Kim, Jae-Sun Uhm, Jong-Youn Kim, Boyoung Joung, Moon-Hyoung Lee, Hui-Nam Pak
BACKGROUND: Although circumferential pulmonary vein isolation (CPVI) catheter ablation may not be sufficient for long-standing persistent atrial fibrillation (L-PeAF), it is not clear which ablation strategy is beneficial in addition to CPVI. We sought to investigate whether additional complex fractionated atrial electrogram (CFAE)-guided ablation improves clinical outcomes in L-PeAF patients who exhibit continuous atrial fibrillation (AF) after CPVI and linear ablation (Line). METHODS AND RESULTS: This study enrolled 137 L-PeAF patients (71...
February 7, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28173880/an-observational-study-to-compare-oral-hygiene-care-with-chlorhexidine-gluconate-gel-versus-mouthwash-to-prevent-ventilator-associated-pneumonia
#10
Hung-Jen Tang, Chien-Ming Chao, Pak-On Leung, Chih-Cheng Lai
No abstract text is available yet for this article.
February 8, 2017: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/28168549/gibbs-energy-additivity-approaches-to-qsrr-in-generating-gas-chromatographic-retention-time-for-identification-of-fatty-acid-methyl-ester
#11
Siriluck Pojjanapornpun, Kornkanok Aryusuk, Supathra Lilitchan, Kanit Krisnangkura
The Gibbs energy additivity method was used to correlate the retention time (t R) of common fatty acid methyl esters (FAMEs) to their chemical structures. The t R of 20 standard FAMEs eluted from three capillary columns of different polarities (ZB-WAXplus, BPX70, and SLB-IL111) under both isothermal gas chromatography and temperature-programmed gas chromatography (TPGC) conditions were accurately predicted. Also, the predicted t R of FAMEs prepared from flowering pak choi seed oil obtained by multistep TPGC with the BPX70 column were within 1...
February 6, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28167293/ethanol-extract-of-the-seed-of-zizyphus-jujuba-var-spinosa-potentiates-hippocampal-synaptic-transmission-through-mitogen-activated-protein-kinase-adenylyl-cyclase-and-protein-kinase-a-pathways
#12
So Yeon Jo, In Ho Jung, Jee Hyun Yi, Tae Joon Choi, Seungheon Lee, Ji Wook Jung, Jeanho Yun, Young Choon Lee, Jong Hoon Ryu, Dong Hyun Kim
ETHNOPHARMACOLOGICAL RELEVANCE: As the seed of Zizyphus jujuba var. spinosa (Bunge) Hu ex H.F. Chow (Rhamnaceae) has been used to sleep disturbances in traditional Chinese and Korean medicine, many previous studies have focused on its sedative effect. AIM OF THE STUDY: Recently, we reported the neuroprotective effect of the effect of Z. jujuba var. spinosa. However, its effects on synaptic function have not yet been studied. In this project, we examined the action of ethanol extract of the seed of Z...
February 3, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28166397/the-utility-of-intraoperative-frozen-section-for-the-evaluation-of-microscopic-extrathyroidal-extension-in-papillary-thyroid-carcinoma
#13
Jong Chul Hong, Ji Won Seo, Ae Lan Jang, Sung Hwan Suh, Min Gyoung Pak, Seong Ho Han, Young Jin Park, Dong Kun Lee, Heon Soo Park, Myung Koo Kang
OBJECTIVES: This study is designed to evaluate the usefulness of intraoperative frozen section for the evaluation of microscopic extrathyroidal extension (ETE) in papillary thyroid carcinoma (PTC). DESIGN: Retrospective cohort study. SETTING: Dong-A University Medical Center, Busan, Korea PARTICIPANTS: Three hundred sixty-four patients who underwent thyroid surgery from January 2000 to December 2010, with PTC confined to one unilateral lobe as diagnosed using preoperative ultrasonography were enrolled...
February 6, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28164413/the-botrytis-cinerea-pak-kinase-bccla4-mediates-morphogenesis-growth-and-cell-cycle-regulating-processes-downstream-of-bcrac
#14
Anna Minz-Dub, Amir Sharon
Rac proteins are involved in a variety of cellular processes. Effector proteins that interact with active Rac convey the GTPase-generated signal to downstream developmental cascades and processes. Here we report on the analysis of the main effector and signal cascade downstream of BcRac, the Rac homolog of the grey mold fungus Botrytis cinerea. Several lines of evidence highlighted the p21-activated kinase Cla4 as an important effector of Rac in fungi. Analysis of Δbccla4 strains revealed that the BcCla4 protein was sufficient to mediate all of the examined BcRac-driven processes, including hyphal growth and morphogenesis, conidia production and pathogenicity...
February 6, 2017: Molecular Microbiology
https://www.readbyqxmd.com/read/28158241/androgen-deprivation-therapy-and-fracture-risk-in-chinese-patients-with-prostate-carcinoma
#15
Chi-Ho Lee, Gang Huang, Pak-Hei Chan, Jojo Hai, Chun-Yip Yeung, Carol Ho-Yi Fong, Yu-Cho Woo, Kwan Lun Ho, Ming-Kwong Yiu, Frankie Leung, Tak-Wing Lau, Hung-Fat Tse, Karen Siu-Ling Lam, Chung-Wah Siu
OBJECTIVE: Androgen deprivation therapy (ADT) increases fracture risk in men with carcinoma of the prostate, but little is known about the fracture risk for different types of ADT. We studied the fracture risk amongst Chinese patients with carcinoma of the prostate prescribed different ADT regimens. SUBJECTS AND METHODS: This was a single-centered observational study that involved 741 patients with carcinoma of the prostate from January 2001 to December 2011. RESULTS: After a median follow-up of 5 years, 71...
2017: PloS One
https://www.readbyqxmd.com/read/28154899/baseline-increased-18f-fluoride-uptake-lesions-at-vertebral-corners-on-positron-emission-tomography-predict-new-syndesmophyte-development-in-ankylosing-spondylitis-a-2-year-longitudinal-study
#16
Eun-Kyoung Park, Kyoungjune Pak, Ji-Heh Park, Keunyoung Kim, Seong-Jang Kim, In-Joo Kim, Geun-Tae Kim, Seung-Geun Lee
The goal of this study was to demonstrate whether increased 18F-fluoride uptake lesions on positron emission tomography (PET) scan can predict new syndesmophyte development in patients with ankylosing spondylitis (AS). In 12 AS patients, 18F-fluoride PET and magnetic resonance imaging (MRI) was performed at baseline, and radiography was performed at baseline and the 2-year follow-up. The following data were recorded: the presence of increased 18F-fluoride uptake lesions on PET defined as an uptake greater than the uptake in the adjacent normal vertebral body; acute (type A) and advanced (type B) corner inflammatory lesions (CILs) and fat lesions on MRI; and syndesmophytes on radiography...
February 2, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28154592/the-trends-of-atrial-fibrillation-related-hospital-visit-and-cost-treatment-pattern-and-mortality-in-korea-10-year-nationwide-sample-cohort-data
#17
Hancheol Lee, Tae-Hoon Kim, Yong-Soo Baek, Jae-Sun Uhm, Hui-Nam Pak, Moon-Hyoung Lee, Boyoung Joung
BACKGROUND AND OBJECTIVES: The change of in-hospital and out-hospital treatments, and hospital costs for atrial fibrillation (AF) were not well known in rapidly aging Asian countries. This study is to examine the trends of AF management and outcomes in Korea. SUBJECTS AND METHODS: In the sample cohort from Korean National Health Insurance Data Sample Cohort (K-NHID-Sample Cohort) from 2004 through 2013, we identified patients with AF and hospital visit records using Korean Classification of Diseases, 6th Revision (KCD-6)...
January 2017: Korean Circulation Journal
https://www.readbyqxmd.com/read/28145530/improving-polygenic-risk-prediction-from-summary-statistics-by-an-empirical-bayes-approach
#18
Hon-Cheong So, Pak C Sham
Polygenic risk scores (PRS) from genome-wide association studies (GWAS) are increasingly used to predict disease risks. However some included variants could be false positives and the raw estimates of effect sizes from them may be subject to selection bias. In addition, the standard PRS approach requires testing over a range of p-value thresholds, which are often chosen arbitrarily. The prediction error estimated from the optimized threshold may also be subject to an optimistic bias. To improve genomic risk prediction, we proposed new empirical Bayes approaches to recover the underlying effect sizes and used them as weights to construct PRS...
February 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28143470/current-use-of-autologous-adipose-tissue-derived-stromal-vascular-fraction-cells-for-orthopedic-applications
#19
REVIEW
Jaewoo Pak, Jung Hun Lee, Kwang Seung Park, Moonhee Park, Lin-Woo Kang, Sang Hee Lee
Autologous adipose stromal vascular fractions (SVFs) containing adipose tissue-derived stem cells (ASCs) are currently being used in clinical settings for various orthopedic applications for human patients. Due to its potential capability of regenerating cartilage, bone, and tendons, autologous adipose SVFs are being tried in treating patients with osteoarthritis (OA), chondromalacia, meniscus tear, osteonecrosis of the femoral head, and tendon injuries. Here, we have reviewed available human clinical studies with regard to patient applications of autologous adipose SVF containing ASCs, specifically assessing effectiveness and safety in the field of orthopedic disorders...
January 31, 2017: Journal of Biomedical Science
https://www.readbyqxmd.com/read/28139299/dineolignans-of-3-o-4-diphenyl-ether-type-from-fruits-of-magnolia-obovata
#20
Kyeong-Hwa Seo, Dae-Young Lee, Yeong-Geun Lee, Nam-In Baek
Seven dineolignans of the 3-O-4' diphenyl ether-type (obovatalignans C-I, respectively), were isolated from fruits of Magnolia obovata through repeated silica gel (SiO2), octadecyl SiO2, and Sep-Pak chromatographies. Their chemical structures were determined based on various spectroscopic methods including NMR, HR-MS, IR, specific rotation, and CD spectrometry. Especially, compounds 1-5 include the relatively rare 1,4-benzodioxane ring moiety in the molecular structure.
January 27, 2017: Phytochemistry
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