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https://www.readbyqxmd.com/read/29672153/p21-activated-kinase4-in-pancreatic-acini-is-activated-by-gi-hormones-growth-factors-by-novel-signaling-and-is-needed-to-stimulate-secretory-growth-cascades
#1
Irene Ramos-Alvarez, Robert T Jensen
p21-activated kinases(PAKs) are highly conserved serine/threonine protein kinases, which are divided into two groups:Group-I(PAKs1-3) and Group-II(PAKs4-6). In various tissues, Group-II PAKs play important roles in cytoskeletal dynamics, cell growth as well as neoplastic development/progression. However, little is known about Group-II PAKs role in a number of physiological events including their ability to be activated by gastrointestinal(GI) hormones/neurotransmitters/growth-factors(GFs). We used rat pancreatic acini to explore the ability of GI-hormones/neurotransmitters/GFs to activate Group-II-PAKs and the signaling cascades involved...
April 19, 2018: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/29671285/effect-of-non-vitamin-k-antagonist-oral-anticoagulants-in-atrial-fibrillation-patients-with-newly-diagnosed-cancer
#2
Kyu Kim, Yong Joon Lee, Tae Hoon Kim, Jae Sun Uhm, Hui Nam Pak, Moon Hyoung Lee, Boyoung Joung
BACKGROUND AND OBJECTIVES: There are limited data on the use of non-vitamin K antagonist oral anticoagulants (NOACs) in atrial fibrillation (AF) patients with cancer. We aimed to assess the efficacy and safety of NOACs in AF patients with cancer in this study. METHODS: In 2,568 consecutive non-valvular AF patients with newly diagnosed cancer, we analyzed ischemic stroke/systemic embolism (SE), major bleeding, and all-cause death. Based on propensity score matching, 388 matched pairs were included in the NOAC and warfarin groups...
February 26, 2018: Korean Circulation Journal
https://www.readbyqxmd.com/read/29670659/beneficial-effects-of-gagam-palmultang-on-scopolamine-induced-memory-deficits-in-mice
#3
Yu Ri Kim, Min Young Kwon, Malk Eun Pak, So Hyun Park, Jin Ung Baek, Byung Tae Choi
From text mining of Dongeuibogam, the 7 herbs in Palmultang can be considered effective candidates for memory enhancement. We sought to determine whether Gagam-Palmultang, comprising these 7 herbs, ameliorates scopolamine-induced memory impairment in mice, by focusing on the central cholinergic system and memory-related signaling molecules. Behavioral tests were performed after inducing memory impairment by scopolamine administration. The cholinergic system activity and memory-related molecules were examined in the hippocampus by enzyme-linked immunosorbent, western blot, and immunofluorescence assays...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29666179/increasing-trends-in-hospital-care-burden-of-atrial-fibrillation-in-korea-2006-through-2015
#4
Daehoon Kim, Pil-Sung Yang, Eunsun Jang, Hee Tae Yu, Tae-Hoon Kim, Jae-Sun Uhm, Jong Youn Kim, Hui-Nam Pak, Moon-Hyoung Lee, Boyoung Joung, Gregory Y H Lip
OBJECTIVE: Temporal changes in the healthcare burden of atrial fibrillation (AF) are less well known in rapidly ageing Asian countries. We examined trends in hospitalisations, costs, treatment patterns and outcomes related to AF in Korea. METHODS: Using the National Health Insurance Service (NHIS) database involving the entire adult Korean population (n=41 701 269 in 2015), we analysed a nationwide AF cohort representing 931 138 patients with AF. We studied all hospitalisations due to AF from 2006 to 2015...
April 17, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29658378/improvement-of-depressive-symptoms-in-patients-with-moderate-to-severe-psoriasis-treated-with-ustekinumab-an-open-label-trial-validated-using-beck-depression-inventory-hamilton-depression-rating-scale-measures-and-18-fluorodeoxyglucose-fdg-positron-emission
#5
Seong-Jang Kim, Min-Young Park, Kyoungjune Pak, Junhee Han, Gun-Wook Kim, Hoon-Soo Kim, Hyun-Chang Ko, Moon-Bum Kim, Byung-Soo Kim
BACKGROUND: Psoriasis is a chronic skin disease associated with psychiatric co-morbidities, especially depression. Early detection of psychological vulnerability in patients with psoriasis seems to be of great clinical importance and significantly impacts the quality of life of the patients. OBJECTIVES: We sought to clarify the association between psoriasis and depressive symptoms in patients with moderate to severe psoriasis, and to determine the risk factors for depressive symptoms and analyse the effect of ustekinumab on the symptoms...
April 16, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29657234/-%C3%A2-terreinlactone-a-a-pair-of-3-substituted-%C3%AE-lactone-enantiomers-derived-from-terrein-from-the-fungus-aspergillus-terreus
#6
Xuwen Zhang, Zhaodi Wu, Yongji Lai, Dongyan Li, Jianping Wang, Zengwei Luo, Yongbo Xue, Hucheng Zhu, Chunmei Chen, Yonghui Zhang
Terreinlactone A (1a/1b), a pair of 3-substituted δ-lactone enantiomers, and terreinlactone B (2), a new biosynthetic intermediate of 1a/1b, were isolated from Aspergillus terreus, along with their biosynthetic precursor (+)-terrein (3) and (+)-isoterrein (4). Compounds 1a and 1b were separated by using a Daicel chiral-pak ASH column eluting with n-hexane-EtOH (80:20). The structures of 1a/1b with absolute configurations were determined by comprehensive spectroscopic analyses and electronic circular dichroic (ECD) calculations...
April 13, 2018: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29657092/the-critical-chemical-and-mechanical-regulation-of-folic-acid-on-neural-engineering
#7
Gloria B Kim, Yongjie Chen, Weibo Kang, Jinshan Guo, Russell Payne, Hui Li, Qiong Wei, Julianne Baker, Cheng Dong, Sulin Zhang, Pak Kin Wong, Elias B Rizk, Jiazhi Yan, Jian Yang
The mandate of folic acid supplementation in grained products has reduced the occurrence of neural tube defects by one third in the U.S since its introduction by the Food and Drug Administration in 1998. However, the advantages and possible mechanisms of action of using folic acid for peripheral nerve engineering and neurological diseases still remain largely elusive. Herein, folic acid is described as an inexpensive and multifunctional niche component that modulates behaviors in different cells in the nervous system...
April 3, 2018: Biomaterials
https://www.readbyqxmd.com/read/29656177/contribution-of-raman-and-surface-enhanced-raman-spectroscopy-sers-to-the-analysis-of-vehicle-headlights-dye-s-characterization
#8
Cyril Muehlethaler, Yin Pak Cheng, Syed K Islam, John R Lombardi
Although ubiquitous on accident scenes, the polymers from headlight optics are often neglected in hit-and-run cases, and their evidential value restrained to direct comparison once a corresponding vehicle is found. Multilayered automotive paint fragments are preferred for their access to corresponding databases (PDQ, EUCAP) to infer models and brands of cars. The potential of polymers headlights for providing forensic intelligence has never been exploited, principally due to the lack of diversity, of appropriate databases, and of case examples...
March 31, 2018: Forensic Science International
https://www.readbyqxmd.com/read/29652885/phosphorelay-through-the-bifunctional-phosphotransferase-phyt-controls-the-general-stress-response-in-an-alphaproteobacterium
#9
Lisa Gottschlich, Miriam Bortfeld-Miller, Christoph Gäbelein, Sebastian Dintner, Julia A Vorholt
Two-component systems constitute phosphotransfer signaling pathways and enable adaptation to environmental changes, an essential feature for bacterial survival. The general stress response (GSR) in the plant-protecting alphaproteobacterium Sphingomonas melonis Fr1 involves a two-component system consisting of multiple stress-sensing histidine kinases (Paks) and the response regulator PhyR; PhyR in turn regulates the alternative sigma factor EcfG, which controls expression of the GSR regulon. While Paks had been shown to phosphorylate PhyR in vitro, it remained unclear if and under which conditions direct phosphorylation happens in the cell, as Paks also phosphorylate the single domain response regulator SdrG, an essential yet enigmatic component of the GSR signaling pathway...
April 2018: PLoS Genetics
https://www.readbyqxmd.com/read/29649547/early-onset-disc-degeneration-in-sm-j-mice-is-associated-with-ion-transport-systems-and-fibrotic-changes
#10
Ying Zhang, Chi Xiong, Mateusz Kudelko, Yan Li, Cheng Wang, Yuk Lun Wong, Vivian Tam, Muhammad Farooq Rai, James Cheverud, Heather A Lawson, Linda Sandell, Wilson C W Chan, Kathryn S E Cheah, Pak C Sham, Danny Chan
Intervertebral disc degeneration (IDD) causes back pain and sciatica, affecting quality of life and resulting in high economic/social burden. The etiology of IDD is not well understood. Along with aging and environmental factors, genetic factors also influence the onset, progression and severity of IDD. Genetic studies of risk factors for IDD using human cohorts are limited by small sample size and low statistical power. Animal models amenable to genetic and functional studies of IDD provide desirable alternatives...
April 9, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/29643768/mirna-431-prevents-amyloid-%C3%AE-induced-synapse-loss-in-neuronal-cell-culture-model-of-alzheimer-s-disease-by-silencing-kremen1
#11
Sean P Ross, Kelly E Baker, Amanda Fisher, Lee Hoff, Elena S Pak, Alexander K Murashov
Synapse loss is well regarded as the underlying cause for the progressive decline of memory function over the course of Alzheimer's disease (AD) development. Recent observations suggest that the accumulation of the Wnt antagonist Dickkopf-1 (Dkk1) in the AD brain plays a critical role in triggering synaptic degeneration. Mechanistically, Dkk1 cooperates with Kremen1 (Krm1), its transmembrane receptor, to block the Wnt/β-catenin signaling pathway. Here, we show that silencing Krm1 with miR-431 prevents amyloid-β-mediated synapse loss in cortico-hippocampal cultures isolated from triple transgenic 3xTg-AD mice...
2018: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29622961/data-sharing-a-new-editorial-initiative-of-the-international-committee-of-medical-journal-editors-implications-for-the-editors-network
#12
EDITORIAL
Fernando Alfonso, Karlen Adamyan, Jean-Yves Artigou, Michael Aschermann, Michael Boehm, Alfonso Buendia, Pao-Hsien Chu, Ariel Cohen, Livio Dei Cas, Mirza Dilic, Anton Doubell, Dario Echeverri, Nuray Enç, Ignacio Ferreira-González, Krzysztof J Filipiak, Andreas Flammer, Eckart Fleck, Plamen Gatzov, Carmen Ginghina, Lino Goncalves, Habib Haouala, Mahmoud Hassanein, Gerd Heusch, Kurt Huber, Ivan Hulín, Mario Ivanusa, Rungroj Krittayaphong, Chu-Pak Lau, Germanas Marinskis, François Mach, Luiz Felipe Moreira, Tuomo Nieminen, Latifa Oukerraj, Stefan Perings, Luc Pierard, Tatjana Potpara, Walter Reyes-Caorsi, Se-Joong Rim, Olaf Rødevand, Georges Saade, Mikael Sander, Evgeny Shlyakhto, Bilgin Timuralp, Dimitris Tousoulis, Dilek Ural, J J Piek, Albert Varga, Thomas F Lüscher
The International Committee of Medical Journal Editors (ICMJE) provides recommendations to improve the editorial standards and scientific quality of biomedical journals. These recommendations range from uniform technical requirements to more complex and elusive editorial issues including ethical aspects of the scientific process. Recently, registration of clinical trials, conflicts of interest disclosure, and new criteria for authorship -emphasizing the importance of responsibility and accountability-, have been proposed...
June 2017: The Egyptian heart journal: (EHJ): official bulletin of the Egyptian Society of Cardiology
https://www.readbyqxmd.com/read/29620004/a-new-dermoscopic-algorithm-for-the-differential-diagnosis-of-facial-lentigo-maligna-and-pigmented-actinic-keratosis
#13
Tamara Micantonio, Luca Neri, Caterina Longo, Simone Grassi, Alessandro Di Stefani, Ambra Antonini, Valeria Coco, Maria Concetta Fargnoli, Giuseppe Argenziano, Ketty Peris
The clinical and dermoscopic diagnosis of facial lentigo maligna (LM) and pigmented actinic keratosis (PAK) remains challenging, particularly at the early disease stages. To identify dermoscopic criteria that might be useful to differentiate LM from PAK, and to elaborate and validate an automated diagnostic algorithm for facial LM/PAK. We performed a retrospective multicentre study to evaluate dermoscopic images of histologically-proven LM and PAK, and assess previously described dermoscopic criteria. In the first part of the study, 61 cases of LM and 74 PAK were examined and a parsimonious algorithm was elaborated using stepwise discriminant analysis...
April 5, 2018: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/29616843/phase-1-trial-of-ibrutinib-and-carfilzomib-combination-therapy-for-relapsed-or-relapsed-and-refractory-multiple-myeloma
#14
Ajai Chari, Sarah Larson, Beata Holkova, Robert F Cornell, Cristina Gasparetto, Chatchada Karanes, Jeffrey V Matous, Ruben Niesvizky, Jason Valent, Matthew Lunning, Saad Z Usmani, Larry D Anderson, Lipo Chang, Yihua Lee, Yvonne Pak, Zeena Salman, Thorsten Graef, Elizabeth Bilotti, Saurabh Chhabra
This phase 1, dose-finding study investigated ibrutinib and carfilzomib ± dexamethasone in patients with relapsed or relapsed/refractory multiple myeloma (≥2 lines of therapy including bortezomib and an immunomodulatory agent). Of 43 patients enrolled, 74% were refractory to bortezomib and 23% had high-risk cytogenetics. No dose-limiting toxicities were observed. The recommended phase 2 dose was ibrutinib 840 mg and carfilzomib 36 mg/m2 with dexamethasone. The most common ≥ grade 3 (>10%) treatment-emergent adverse events were hypertension, anemia, pneumonia, fatigue, diarrhea, and thrombocytopenia...
April 4, 2018: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/29616051/effect-of-solid-biological-waste-compost-on-the-metabolite-profile-of-brassica-rapa-ssp-chinensis
#15
Susanne Neugart, Melanie Wiesner-Reinhold, Katja Frede, Elisabeth Jander, Thomas Homann, Harshadrai M Rawel, Monika Schreiner, Susanne Baldermann
Large quantities of biological waste are generated at various steps within the food production chain and a great utilization potential for this solid biological waste exists apart from the current main usage for the feedstuff sector. It remains unclear how the usage of biological waste as compost modulates plant metabolites. We investigated the effect of biological waste of the processing of coffee, aronia, and hop added to soil on the plant metabolite profile by means of liquid chromatography in pak choi sprouts...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29606188/short-form-of-weinstein-noise-sensitivity-scale-nss-sf-reliability-validity-and-gender-invariance-among-chinese-individuals
#16
Tao Zhong, Pak-Kwong Chung, Jing Dong Liu
OBJECTIVE: Independent from noise exposure, noise sensitivity plays a pivotal role in people's noise annoyance perception and concomitant health deteriorations. The present study empirically investigated the psychometric properties of the Chinese version of the Weinstein Noise Sensitivity Scale-Short Form (CNSS-SF), the widely used inventory measuring individual differences in noise perception. METHODS: In total, 373 Chinese participants (age = 21.41 ± 3.36) completed the online, anonymous questionnaire package...
February 2018: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/29604334/alternative-translation-initiation-of-caveolin-2-desensitizes-insulin-signaling-through-dephosphorylation-of-insulin-receptor-by-ptp1b-and-causes-insulin-resistance
#17
Hayeong Kwon, Jaewoong Lee, Donghwan Jang, Moonjeong Choi, Kyuho Jeong, Yunbae Pak
Insulin resistance, defined as attenuated sensitivity responding to insulin, impairs insulin action. Direct causes and molecular mechanisms of insulin resistance have thus far remained elusive. Here we show that alternative translation initiation (ATI) of Caveolin-2 (Cav-2) regulates insulin sensitivity. Cav-2β isoform yielded by ATI desensitizes insulin receptor (IR) via dephosphorylation by protein-tyrosine phosphatase 1B (PTP1B), and subsequent endocytosis and lysosomal degradation of IR, causing insulin resistance...
March 28, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29599630/potential-benefits-of-annona-muricata-in-combating-cancer-a-review
#18
REVIEW
Aidy Irman Yajid, Husna Syakirah Ab Rahman, Michael Pak Kai Wong, Wan Zainira Wan Zain
The incidence of cancer is increasing each year, which generates concerns regarding the efficacy of the current treatment options. This has caused patients to seek alternatives to complement or to replace surgery, chemotherapy and radiotherapy. Annona muricata and other plants have been shown to have promising compounds that can be utilised in the treatment of cancer. Native to the tropical and subtropical parts of the world, A. muricata plant extracts contain compounds that are particularly effective against cancer cells...
February 2018: Malaysian Journal of Medical Sciences: MJMS
https://www.readbyqxmd.com/read/29599099/predictive-value-of-acute-kidney-injury-for-major-adverse-cardiovascular-events-following-tricuspid-annuloplasty-a-comparison-of-three-consensus-criteria
#19
Mei-Zhen Wu, Yan Chen, Wing-Kok Au, Daniel Chan, Ko-Yung Sit, Kar-Lai Ho, Lai-Ming Ho, Yui-Ming Lam, Chu-Pak Lau, Tak-Mao Chan, Hung-Fat Tse, Kai-Hang Yiu
BACKGROUND: Tricuspid annuloplasty (TA) is increasingly being performed, but the clinical outcome is unsatisfactory. Acute kidney injury (AKI) is a common complication following cardiac surgery and predicts outcome. Nonetheless the occurrence rate and prognostic value of AKI after TA are unclear. METHODS: This study reviewed 339 consecutive patients (age 65±11 years; male 42%) who underwent TA. The incidence of AKI was defined according to risk/injury/failure/loss/end stage (RIFLE), acute kidney injury network (AKIN), and kidney disease improving global outcomes (KDIGO) criteria, respectively...
March 26, 2018: Journal of Cardiology
https://www.readbyqxmd.com/read/29597073/p21-activated-kinase-1-nuclear-activity-and-its-role-during-dna-damage-repair
#20
REVIEW
Eloy Andrés Pérez-Yépez, Héctor Iván Saldívar-Cerón, Olga Villamar-Cruz, Carlos Pérez-Plasencia, Luis Enrique Arias-Romero
p21-activated kinase 1 (PAK1) is a serine/threonine kinase activated by the small GTPases Rac1 and Cdc42. It is located in the chromosome 11q13 and is amplified and/or overexpressed in several human cancer types including 25-30% of breast tumors. This enzyme plays a pivotal role in the control of a number of fundamental cellular processes by phosphorylating its downstream substrates. In addition to its role in the cytoplasm, it is well documented that PAK1 also plays crucial roles in the nucleus participating in mitotic events and gene expression through its association and/or phosphorylation of several transcription factors, transcriptional co-regulators and cell cycle-related proteins, including Aurora kinase A (AURKA), polo-like kinase 1 (PLK1), the forkhead transcription factor (FKHR), estrogen receptor α (ERα), and Snail...
March 21, 2018: DNA Repair
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