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https://www.readbyqxmd.com/read/28530709/recognition-of-egf-like-domains-by-the-notch-modifying-o-fucosyltransferase-pofut1
#1
Zhijie Li, Kristina Han, John E Pak, Malathy Satkunarajah, Dongxia Zhou, James M Rini
Protein O-fucosyltransferase 1 (POFUT1) fucosylates the epidermal growth factor (EGF)-like domains found in cell-surface and secreted glycoproteins including Notch and its ligands. Although Notch fucosylation is critical for development, and POFUT1 deficiency leads to human disease, how this enzyme binds and catalyzes the fucosylation of its diverse EGF-like domain substrates has not been determined. Reported here is the X-ray crystal structure of mouse POFUT1 in complex with several EGF-like domains, including EGF12 and EGF26 of Notch...
May 22, 2017: Nature Chemical Biology
https://www.readbyqxmd.com/read/28530030/data-sharing-a-new-editorial-initiative-of-the-international-committee-of-medical-journal-editors-implications-for-the-editors-network
#2
Fernando Alfonso, Karlen Adamyan, Jean-Yves Artigou, Michael Aschermann, Michael Boehm, Alfonso Buendia, Pao-Hsien Chu, Ariel Cohen, Livio Dei Cas, Mirza Dilic, Anton Doubell, Dario Echeverri, Nuray Enç, Ignacio Ferreira-González, Krzysztof J Filipiak, Andreas Flammer, Eckart Fleck, Plamen Gatzov, Carmen Ginghina, Lino Goncalves, Habib Haouala, Mahmoud Hassanein, Gerd Heusch, Kurt Huber, Ivan Hulín, Mario Ivanusa, Rungroj Krittayaphong, Chu-Pak Lau, Germanas Marinskis, François Mach, Luiz Felipe Moreira, Tuomo Nieminen, Latifa Oukerraj, Stefan Perings, Luc Pierard, Tatjana Potpara, Walter Reyes-Caorsi, Se-Joong Rim, Olaf Rødevand, Georges Saade, Mikael Sander, Evgeny Shlyakhto, Bilgin Timuralp, Dimitris Tousoulis, Dilek Ural, J J Piek, Albert Varga, Thomas F Lüscher
The International Committee of Medical Journal Editors (ICMJE) provides recommendations to improve the editorial standards and scientific quality of biomedical journals. These recommendations range from uniform technical requirements to more complex and elusive editorial issues including ethical aspects of the scientific process. Recently, registration of clinical trials, conflicts of interest disclosure, and new criteria for authorship - emphasizing the importance of responsibility and accountability - have been proposed...
2017: Kardiologia Polska
https://www.readbyqxmd.com/read/28526752/the-apical-ecm-preserves-embryonic-integrity-and-distributes-mechanical-stress-during-morphogenesis
#3
Thanh Thi Kim Vuong-Brender, Shashi Kumar Suman, Michel Labouesse
Epithelia are bound by both basal and apical extracellular matrices (ECM). While the composition and function of the former have been intensively investigated, less is known about the latter. The embryonic sheath, the ECM apical to the C. elegans embryonic epidermis, has been suggested to promote its elongation. In an RNAi screen for the components of the sheath, we identified the Zona Pellucida domain proteins NOAH-1 and NOAH-2. We found that these proteins act in the same pathway, and in parallel to three other putative sheath proteins, SYM-1, LET-4 and FBN-1/Fibrillin, to ensure embryonic integrity and promote elongation...
May 19, 2017: Development
https://www.readbyqxmd.com/read/28522792/transgenic-autoinhibition-of-p21-activated-kinase-exacerbates-synaptic-impairments-and-fronto-dependent-behavioral-deficits-in-an-animal-model-of-alzheimer-s-disease
#4
Cyril Bories, Dany Arsenault, Myriam Lemire, Cyntia Tremblay, Yves De Koninck, Frédéric Calon
Defects in p21-activated kinase (PAK) lead to dendritic spine abnormalities and are sufficient to cause cognition impairment. The decrease in PAK in the brain of Alzheimer's disease (AD) patients is suspected to underlie synaptic and dendritic disturbances associated with its clinical expression, particularly with symptoms related to frontal cortex dysfunction. To investigate the role of PAK combined with Aβ and tau pathologies (3xTg-AD mice) in the frontal cortex, we generated a transgenic model of AD with a deficit in PAK activity (3xTg-AD-dnPAK mice)...
May 16, 2017: Aging
https://www.readbyqxmd.com/read/28521190/simultaneous-determination-of-bisphenol-a-and-estrogens-in-hair-samples-by-liquid-chromatography-electrospray-tandem-mass-spectrometry
#5
Chaelin Lee, Chong Hyeak Kim, Sunghwan Kim, Sung-Hee Cho
Bisphenol A (BPA), an endocrine disrupter, is widely used to make chemicals for polycarbonate, plastics, beverage containers, epoxy resins, and cash register receipts. BPA is one of the known xenoestrogens, which have weak estrogenic activity and cause obesity, diabetes, breast cancer, and reproductive disorders. Even though the concentration level of metabolomes in hair is usually lower than that in urine and blood, there are several reasons why we chose to use hair samples. First, the sampling procedure of hairs is simple...
May 11, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28516310/natural-history-of-patients-followed-radiographically-with-mucinous-cysts-of-the-pancreas
#6
Linda M Pak, Michael I D'Angelica, Ronald P DeMatteo, T Peter Kingham, Vinod P Balachandran, William R Jarnagin, Peter J Allen
OBJECTIVE: The aim of this study was to evaluate the outcome of patients presumed to have mucinous cysts of the pancreas who were initially selected for radiographic surveillance. METHODS: Patients with a pancreatic cyst and a measured cyst fluid carcinoembryonic antigen (CEA) ≥192 ng/mL were included. Patients were stratified by those who underwent initial resection and those who were recommended for radiographic surveillance. The natural history of these two groups was examined...
May 17, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28514502/structural-and-functional-characteristics-of-estrogen-receptor-beta-er%C3%AE-splice-variants-implications-for-the-aging-brain
#7
REVIEW
Chun K Kim, Audrey Torcaso, AnnaDorothea Asimes, Wilson C J Chung, Toni R Pak
Estrogen receptor beta (ERβ) is a multifunctional nuclear receptor that mediates the actions of estrogenic compounds. Despite its well defined role in mediating the actions of estrogens, a substantial body of evidence demonstrates that ERβ has broad range of physiological functions that are independent of those normally attributed to estrogen signaling. These functions can, in part, be achieved by the activity of several alternatively spliced isoforms that have been identified for ERβ. This short review will describe structural differences between the ERβ splice variants that are known to be translated into proteins...
May 17, 2017: Journal of Neuroendocrinology
https://www.readbyqxmd.com/read/28507944/a-survey-on-phytochemical-composition-and-biological-activity-of-zygophyllum-fabago-from-iran
#8
Saeid Yaripour, Mohammad-Reza Delnavazi, Parina Asgharian, Samira Valiyari, Saeed Tavakoli, Hossein Nazemiyeh
Purpose: Zygophyllum fabago L. (Z. fabago) is a widespread perennial herb which is used as a medicinal plant in traditional medicine of Iran, Turkey and China. The present study was a survey on phytochemical constituents and biological activities of this plant. Methods: Methanolic extract of the roots was fractionated over a C-18 pre-packed cartridge (Sep-pak) and chromatographic separation was performed on a reversed-phase preparative HPLC. Structural elucidation of the isolated compounds was carried out using UV, (1)H-NMR and 13C-NMR spectral analyses...
April 2017: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28502643/are-brucellosis-q-fever-and-melioidosis-potential-causes-of-febrile-illness-in-madagascar
#9
Ides Boone, Klaus Henning, Angela Hilbert, Heinrich Neubauer, Vera von Kalckreuth, Denise Myriam Dekker, Norbert Georg Schwarz, Gi Deok Pak, Andreas Krüger, Ralf Matthias Hagen, Hagen Frickmann, Jean Noël Heriniaina, Raphael Rakotozandrindrainy, Jean Philibert Rakotondrainiarivelo, Tsiry Razafindrabe, Benedikt Hogan, Jürgen May, Florian Marks, Sven Poppert, Sascha Al Dahouk
Brucellosis, Q fever and melioidosis are zoonoses, which can lead to pyrexia. These diseases are often under-ascertained and underreported because of their unspecific clinical signs and symptoms, insufficient awareness by physicians and public health officers and limited diagnostic capabilities, especially in low-resource countries. Therefore, the presence of Brucella spp., Coxiella burnetii and Burkholderia pseudomallei was investigated in Malagasy patients exhibiting febrile illness. In addition, we analyzed zebu cattle and their ticks as potential reservoirs for Brucella and C...
May 11, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28502422/preimplantation-genetic-diagnosis-for-monogenic-diseases
#10
REVIEW
Vivian Chi Yan Lee, Judy F C Chow, William Shu Biu Yeung, Pak Chung Ho
Preimplantation genetic diagnosis (PGD) was first reported in 1990. Thereafter, more and more indications for PGD, including monogenic diseases (MGD) and translocations, are presently available, and the list of indications of PGD is expanding from early-onset and serious conditions to late-onset diseases. Polymerase chain reaction has been used for PGD of MGD, while newer techniques, including karyomapping and next-generation sequencing, emerge in recent decade. The limitations of various methods for PGD are discussed in this review...
April 15, 2017: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/28499708/incidence-of-intermediate-stage-age-related-macular-degeneration-in-patients-with-the-acquired-immunodeficiency-syndrome
#11
Douglas A Jabs, Mark L Van Natta, Jeong Won Pak, Ronald P Danis, Peter W Hunt
PURPOSE: To evaluate the incidence of intermediate-stage age-related macular degeneration (AMD) in patients with the acquired immunodeficiency syndrome (AIDS). DESIGN: Cohort study. METHODS: Patients enrolled in the Longitudinal Study of the Ocular Complications of AIDS (LSOCA) underwent 5- and 10-year follow-up retinal photographs. Intermediate-stage AMD (AREDS stage 3) was determined from these photographs by graders at a centralized Reading Center, using the Age-Related Eye Disease Study-2 grading system...
May 9, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28498372/comparative-transcriptomics-analyses-reveal-the-conservation-of-an-ancestral-infectious-strategy-in-two-bacteriophage-genera
#12
Bob G Blasdel, Anne Chevallereau, Marc Monot, Rob Lavigne, Laurent Debarbieux
Although the evolution of tailed bacteriophages has increasingly been better understood through comparisons of their DNA sequences, the functional consequences of this evolution on phage infectious strategies have remained unresolved. In this study, we comprehensively compared the transcriptional strategies of two related myoviruses, PAK_P3 and PAK_P4, infecting the same Pseudomonas aeruginosa host strain. Outside of the conservation of their structural clusters, their highly syntenic genomes display only limited DNA similarity...
May 12, 2017: ISME Journal
https://www.readbyqxmd.com/read/28497976/copper-i-catalyzed-interrupted-click-reaction-with-tmscf3-synthesis-of-5-trifluoromethyl-1-2-3-triazoles
#13
Kelvin Pak Shing Cheung, Gavin Chit Tsui
We herein describe a Cu(I)-catalyzed interrupted click reaction, using (trifluoromethyl)trimethylsilane (TMSCF3) as a nucleophilic CF3 source, to synthesize 5-trifluoromethyl 1,2,3-triazoles in one step from readily available terminal alkynes and azides. The reaction shows complete regioselectivity, broad substrate scope, and good functional group tolerability. The application of the reaction has been demonstrated in the synthesis of a trifluoromethylated analog of antiepileptic drug rufinamide.
May 12, 2017: Organic Letters
https://www.readbyqxmd.com/read/28496963/in-vitro-comparison-of-biological-effects-of-coe-pak-and-reso-pac-periodontal-dressings
#14
Mahdi Kadkhodazadeh, Zahra Baghani, Maryam Torshabi, Bahar Basirat
OBJECTIVES: The purpose of the present study was to compare the cytotoxicity of Reso-Pac and Coe-Pak periodontal dressing. MATERIAL AND METHODS: According to ISO-10993-12:2012, 1-, 3- and 7-day extracts of the two periodontal dressings were prepared in cell culture medium and exposed to the two cultured cell lines. Cell viability and proliferation at 24 h and 72 h following exposure were evaluated using quantitative MTT assay. RESULTS: The results showed a significant (P < 0...
January 2017: Journal of Oral & Maxillofacial Research
https://www.readbyqxmd.com/read/28495956/sharing-of-genes-and-pathways-across-complex-phenotypes-a-multilevel-genome-wide-analysis
#15
Hongsheng Gui, Johnny S Kwan, Pak C Sham, Stacey S Cherny, Miaoxin Li
Evidence from genome-wide association studies (GWAS) suggest that pleiotropic effects on human complex phenotypes are very common. Recently an atlas of genetic correlations among complex phenotypes has broadened our understanding of human diseases and traits. Here we examine genetic overlap, from a gene-centric perspective, among the same 24 phenotypes previously investigated for genetic correlations. After adopting the multilevel pipeline (freely available at http://grass.cgs.hku.hk/limx/kgg/) that includes intragenic single nucleotide polymorphisms (SNPs), genes and gene-sets to estimate genetic similarities across phenotypes, large amount of sharing for several biologically related phenotypes is confirmed...
May 11, 2017: Genetics
https://www.readbyqxmd.com/read/28493371/effects-of-repetitive-transcranial-magnetic-stimulation-on-improvement-of-cognition-in-elderly-patients-with-cognitive-impairment-a-systematic-review-and-meta-analysis
#16
REVIEW
Calvin Pak Wing Cheng, Corine Sau Man Wong, Kelsey Kimyin Lee, Alfred Pui Kam Chan, Jerry Wing Fai Yeung, Wai Chi Chan
OBJECTIVE: This systematic review and meta-analysis aimed to examine the effects of repetitive transcranial magnetic stimulation (rTMS) on cognitive function in older patients with cognitive impairment. METHODS: A literature search was performed for articles published in English using the 10 databases (MEDLINE, EMBASE, PsycINFO, INSPEC, the Cumulative Index to Nursing and Allied Health Literature Plus, AMED, Biological Sciences, ClinicalTrials.gov, the Cochrane Central Register of Controlled Trials and the Cochrane Database of Systematic Reviews) from their inception to May 2016...
May 11, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28492693/nickel-catalyzed-enantioselective-hydroarsination-of-nitrostyrene
#17
Wee Shan Tay, Xiang-Yuan Yang, Yongxin Li, Sumod A Pullarkat, Pak-Hing Leung
A catalytic asymmetric hydroarsination reaction of an activated alkene viz. (E)-nitrostyrene was developed using chiral PCP Pt-, Pd- and Ni-pincer complexes as catalysts. The corresponding chiral tertiary arsine adduct was obtained in ees of up to 80% under mild reaction conditions using the PCP Ni-Cl pincer catalyst. The arsine adduct was furnished with catalyst loadings of 1-5 mol% and the reaction duration ranging from <5 min to 180 min. The subsequent coordination of the hydroarsination product to gold(i) chloride allowed for the confirmation of the stereochemistry of the arsine adduct via crystallographic analysis...
May 11, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28492341/implications-of-neurovascular-uncoupling-in-functional-magnetic-resonance-imaging-fmri-of-brain-tumors
#18
Rebecca W Pak, Darian H Hadjiabadi, Janaka Senarathna, Shruti Agarwal, Nitish V Thakor, Jay J Pillai, Arvind P Pathak
Functional magnetic resonance imaging (fMRI) serves as a critical tool for presurgical mapping of eloquent cortex and changes in neurological function in patients diagnosed with brain tumors. However, the blood-oxygen-level-dependent (BOLD) contrast mechanism underlying fMRI assumes that neurovascular coupling remains intact during brain tumor progression, and that measured changes in cerebral blood flow (CBF) are correlated with neuronal function. Recent preclinical and clinical studies have demonstrated that even low-grade brain tumors can exhibit neurovascular uncoupling (NVU), which can confound interpretation of fMRI data...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28491743/quinidine-for-brugada-syndrome-panacea-or-poison
#19
Jo-Jo Hai, Chun-Ka Wong, Pak-Hei Chan, Hung-Fat Tse, Tak-Cheung Yung, Chung-Wah Siu
No abstract text is available yet for this article.
November 2016: HeartRhythm Case Reports
https://www.readbyqxmd.com/read/28488592/reduction-of-interface-traps-between-poly-si-and-sio2-layers-through-the-dielectric-recovery-effect-during-delayed-pulse-bias-stress
#20
Dong Uk Lee, Sangwoo Pak, Daemyoung Lee, Yihun Kim, Haechang Yang, Sanghoo Hong, Seungjun Lee, Eun Kyu Kim
We investigate the interface trap behavior between tunneling oxide and poly-Si channel layer post erase/write cycling with a delayed pulse by using deep level transient spectroscopy. For comparison of the defect states depending on the stress pulses, a Schottky and a metal-oxide semiconductor device were fabricated. A defect state at about E c -0.51 eV in the Schottky device was measured before the annealing process. Three-hole trap states with activation energies of E v +0.28 eV, E v +0.53 eV, and E v +0...
May 10, 2017: Nanotechnology
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