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https://www.readbyqxmd.com/read/29454138/prognostic-implications-of-early-monomorphic-and-non-monomorphic-tachyarrhythmias-in-patients-discharged-with-acute-coronary-syndrome
#1
Jo-Jo Hai, Ka-Chun Un, Chun-Ka Wong, Ka-Lam Wong, Zhe-Yu Zhang, Pak-Hei Chan, Chu-Pak Lau, Chung-Wah Siu, Hung-Fat Tse
BACKGROUND: The prognostic implication of early ventricular tachycarrhythmias (VT) after acute coronary syndrome (ACS) remains unclear. OBJECTIVE: We sought to investigate the clinical outcomes of early monomorphic and non-monomorphic VT that occur within 48 hours in patients after ACS. METHODS: We retrospectively reviewed the clinical outcomes of 2033 (mean age: 67.0±13.4 years, 73.1% male) consecutive patients who presented with ACS from 2004 to 2015...
February 14, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29454098/quantitative-imaging-features-and-postoperative-hepatic-insufficiency-a-multi-institutional-expanded-cohort
#2
Linda M Pak, Jayasree Chakraborty, Mithat Gonen, William C Chapman, Richard Kg Do, Bas Groot Koerkamp, Kees Verhoef, Ser Yee Lee, Marco Massani, Eric P van der Stok, Amber L Simpson
BACKGROUND: Post-hepatectomy liver insufficiency (PHLI) is a significant cause of morbidity and mortality after liver resection. Quantitative imaging analysis using CT scans measures variations in pixel intensity related to perfusion. A preliminary study demonstrated a correlation between quantitative imaging features of the future liver remnant (FLR) parenchyma from preoperative CT scans and PHLI. The objective of the present study was to explore the potential application of quantitative imaging analysis in PHLI in an expanded, multi-institutional cohort...
February 14, 2018: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/29453068/effect-of-selenium-enriched-organic-material-amendment-on-selenium-fraction-transformation-and-bioavailability-in-soil
#3
Dan Wang, Quang Toan Dinh, Tran Thi Anh Thu, Fei Zhou, Wenxiao Yang, Mengke Wang, Weiwei Song, Dongli Liang
To exploit the plant byproducts from selenium (Se) biofortification and reduce environmental risk of inorganic Se fertilizer, pot experiment was conducted in this study. The effects of Se-enriched wheat (Triticum aestivum L.) straw (WS + Se) and pak choi (Brassica chinensis L.) (P + Se) amendment on organo-selenium speciation transformation in soil and its bioavailability was evaluated by pak choi uptake. The Se contents of the cultivated pak choi in treatments amended with the same amount of Se-enriched wheat straw and pak choi were 1...
February 5, 2018: Chemosphere
https://www.readbyqxmd.com/read/29445354/effects-of-acupuncture-on-the-recovery-outcomes-of-stroke-survivors-with-shoulder-pain-a-systematic-review
#4
Janita Pak Chun Chau, Suzanne Hoi Shan Lo, Xingfeng Yu, Kai Chow Choi, Alexander Yuk Lun Lau, Justin Che Yuen Wu, Vivian Wing Yan Lee, William Hoi Ngai Cheung, Jessica Yuet Ling Ching, David R Thompson
Background: Poststroke shoulder pain limits stroke survivors' physical functioning, impairs their ability to perform daily activities, and compromises their quality of life. The use of acupuncture to manage shoulder pain after a stroke is believed to free the blockage of energy flow and produce analgesic effects, but the evidence is unclear. We therefore conducted a systematic review to summarize the current evidence on the effects of acupuncture on the recovery outcomes of stroke survivors with shoulder pain...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29445310/training-in-emerging-advances-in-chronic-hepatitis-c-infection-in-pakistan-the-teach-pak-project
#5
Faisal W Ismail, Shahab Abid, Minaz Mawani, Wasim Jafri, Saeed S Hamid
Purpose: Viral hepatitis B and C represent the primary health challenge confronting Asia and Pakistan. With direct-acting antiviral therapy for hepatitis C, patients will be treated by general physicians (GPs) and will need training through continuing medical education (CME). Blended learning is a combination of didactic teaching with online, self-paced learning, and it has not been evaluated as a CME tool for general physicians. We aimed to compare the change in physician's knowledge about chronic viral hepatitis following a blended learning educational program...
2018: Advances in Medical Education and Practice
https://www.readbyqxmd.com/read/29444127/reducing-vertices-in-property-graphs
#6
Dominik Tomaszuk, Karol Pąk
Graph databases are constantly growing, and, at the same time, some of their data is the same or similar. Our experience with the management of the existing databases, especially the bigger ones, shows that certain vertices are particularly replicated there numerous times. Eliminating repetitive or even very similar data speeds up the access to database resources. We present a modification of this approach, where similarly we group together vertices of identical properties, but then additionally we join together groups of data that are located in distant parts of a graph...
2018: PloS One
https://www.readbyqxmd.com/read/29436197/the-role-of-serotonin-in-ventricular-repolarization-in-pregnant-mice
#7
Shanyu Cui, Hyewon Park, Hyelim Park, Dasom Mun, Seung Hyun Lee, Hyoeun Kim, Nuri Yun, Hail Kim, Michael Kim, Hui Nam Pak, Moon Hyoung Lee, Boyoung Joung
PURPOSE: The mechanisms underlying repolarization abnormalities during pregnancy are not fully understood. Although maternal serotonin (5-hydroxytryptamine, 5-HT) production is an important determinant for normal fetal development in mice, its role in mothers remains unclear. We evaluated the role of serotonin in ventricular repolarization in mice hearts via 5Htr3 receptor (Htr3a) and investigated the mechanism of QT-prolongation during pregnancy. MATERIALS AND METHODS: We measured current amplitudes and the expression levels of voltage-gated K⁺ (Kv) channels in freshly-isolated left ventricular myocytes from wild-type non-pregnant (WT-NP), late-pregnant (WT-LP), and non-pregnant Htr3a homozygous knockout mice (Htr3a(-/-)-NP)...
March 2018: Yonsei Medical Journal
https://www.readbyqxmd.com/read/29436191/cha%C3%A2-ds%C3%A2-vasc-score-in-the-prediction-of-ischemic-stroke-in-patients-after-radiofrequency-catheter-ablation-of-typical-atrial-flutter
#8
Moo Nyun Jin, Changho Song, Tae Hoon Kim, Jae Sun Uhm, Hui Nam Pak, Moon Hyoung Lee, Boyoung Joung
PURPOSE: Despite undergoing successful catheter ablation of typical atrial flutter (AFL), patients remain at increased risk for ischemic stroke. However, data on risk prediction tools for the development of stroke after AFL ablation are lacking. This study investigates whether CHA₂DS₂-VASc score is useful for predicting ischemic stroke after successful ablation of typical AFL. MATERIALS AND METHODS: A total of 293 patients (236 men, mean age 56.1±13.5 years) who underwent successful radiofrequency catheter ablation for typical AFL were included in this study...
March 2018: Yonsei Medical Journal
https://www.readbyqxmd.com/read/29435590/association-of-retinal-vascular-caliber-and-age-related-macular-degeneration-in-patients-with-the-acquired-immunodeficiency-syndrome
#9
Douglas A Jabs, Mark L Van Natta, Jeong Won Pak, Ronald P Danis, Peter W Hunt
Purpose: To evaluate the relationship between retinal vascular caliber and AMD in patients with AIDS. Methods: Participants enrolled in the Longitudinal Study of the Ocular Complications of AIDS had retinal photographs taken at enrollment. Retinal vascular caliber (central retinal artery equivalent [CRAE] and central retinal vein equivalent [CRVE]) and intermediate-stage AMD were determined from these retinal photographs. Photographs were evaluated by graders at a centralized reading center, using the Age-Related Eye Disease Study grading system for AMD and semiautomated techniques for evaluating retinal vascular caliber...
February 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29434926/pak5-overexpression-is-associated-with-lung-metastasis-in-osteosarcoma
#10
Kun Han, Yan Zhou, Kuo-Fu Tseng, Haiyan Hu, Kunpeng Li, Yaling Wang, Zhihua Gan, Shuchen Lin, Yongning Sun, Daliu Min
p21-activated kinases (PAKs) are multifunctional effectors of Rho GTPases, which are associated with cytoskeletal organization, cellular morphogenesis, migration and survival. PAKs are overactive in a number of tumor tissues and have attracted attention as a potential target for cancer therapy. In the present study, PAK5 levels were analyzed in primary osteosarcoma (OS) samples (n=65) using reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and immunohistochemistry (IHC) methods. In the primary OS tissue, increased PAK5 expression (IHC score >2, n=37) was associated with significantly decreased overall survival (P=0...
February 2018: Oncology Letters
https://www.readbyqxmd.com/read/29433159/prognostic-utility-of-histological-growth-patterns-of-colorectal-lung-oligometastases
#11
Son Jae Yeong, Min Gyoung Pak, Hyoun Wook Lee, Seung Yeon Ha, Mee Sook Roh
Background: Patients with resectable colorectal lung oligometastases demonstrate a heterogeneous oncological outcome. However, the parameters for predicting tumor aggressiveness have not yet been fully investigated in colorectal lung metastases (CLM). This study was performed to determine the prognostic value of histological growth patterns in patients who underwent surgery for CLM. Materials and Methods: The study included 92 patients who were diagnosed with CLM among the first resection cases...
February 12, 2018: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/29432497/autologous-t-cells-expressing-the-oncogenic-transcription-factor-klf6-sv1-prevent-apoptosis-of-chronic-lymphocytic-leukemia-cells
#12
Parviz Kokhaei, Mohammad Hojjat-Farsangi, Fariba Mozaffari, Ali Moshfegh, Fatemeh Pak, Ali Rashidy-Pour, Marzia Palma, Lotta Hansson, Anders Österborg, Håkan Mellstedt
Crosstalk between leukemic cells and the tumor microenvironment is of importance in chronic lymphocytic leukemia (CLL). T cells seem to sustain the survival of CLL cells by various mechanisms. The Krüppel-like family of transcription factors (KLFs) are identified as regulators of proliferation and cell death. In the present study, we analyzed the expression of the wild type (WT) gene KLF6 and the oncogenic splice variant 1 (KLF6-SV1) at the mRNA level in subsets of T cells from CLL patients (n = 29), multiple myeloma patients (n = 6) and normal donors (n = 10)...
2018: PloS One
https://www.readbyqxmd.com/read/29432336/limited-documentation-and-treatment-quality-of-glycemic-inpatient-care-in-relation-to-structural-deficits-of-heterogeneous-insulin-charts-at-a-large-university-hospital
#13
Julia Kopanz, Katharina M Lichtenegger, Gerald Sendlhofer, Barbara Semlitsch, Gerald Cuder, Andreas Pak, Thomas R Pieber, Christa Tax, Gernot Brunner, Johannes Plank
OBJECTIVES: Insulin charts represent a key component in the inpatient glycemic management process. The aim was to evaluate the quality of structure, documentation, and treatment of diabetic inpatient care to design a new standardized insulin chart for a large university hospital setting. METHODS: Historically grown blank insulin charts in use at 39 general wards were collected and evaluated for quality structure features. Documentation and treatment quality were evaluated in a consecutive snapshot audit of filled-in charts...
February 9, 2018: Journal of Patient Safety
https://www.readbyqxmd.com/read/29431972/beta-blockers-compared-with-other-drug-options-for-the-treatment-of-hypertension
#14
Edwin Choi, Grace Pak, Jeffrey Burket
No abstract text is available yet for this article.
February 1, 2018: American Family Physician
https://www.readbyqxmd.com/read/29429702/water-molecular-emission-from-cavitation-bubbles-affected-by-electric-fields
#15
Hyang-Bok Lee, Pak-Kon Choi
Orange emission was observed during multibubble sonoluminescence at 1 MHz in water saturated with noble gas. The emission arose in the vicinity of the peeled ground electrode of a piezoceramic transducer exposed to water, suggesting that cavitation bubbles were affected by the electric fields that leaked from the transducer. The spectrum of the emission exhibited a broad component whose intensity increased towards the near-infrared region with peaks at 713 and 813 nm. The spectral shape was independent of the saturation gas of He, Ne, or Kr...
April 2018: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/29427364/crohn-s-disease-associated-strictures
#16
REVIEW
Webber Chan Pak Wo, Fadi Mourad, Rupert W L Leong
Crohn's disease (CD) is a chronic relapsing and remitting disease that can affect any segments of the gastrointestinal (GI) tract. More than 50% of patients with CD develop stricturing or penetrating complications within the first 10 years after diagnosis. Strictures can lead to intestinal obstruction, which is a common indication for surgery. Despite significant advances in the understanding of the pathogenesis of intestinal fibrostenosis, imaging and therapeutic armamentarium of CD, the risk of intestinal surgery remained significantly high...
February 10, 2018: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29425966/genotype-assembly-biological-activity-and-adaptation-of-spatially-separated-isolates-of-spodoptera-litura-nucleopolyhedrovirus
#17
Ghulam Ali, Marleen H C Abma-Henkens, Wopke van der Werf, Lia Hemerik, Just M Vlak
The cotton leafworm Spodoptera litura is a polyphagous insect. It has recently made a comeback as a primary insect pest of cotton in Pakistan due to reductions in pesticide use on the advent of genetically modified cotton, resistant to Helicoverpa armigera. Spodoptera litura nucleopolyhedrovirus (SpltNPV) infects S. litura and is recognized as a potential candidate to control this insect. Twenty-two NPV isolates were collected from S. litura from different agro-ecological zones (with collection sites up to 600 km apart) and cropping systems in Pakistan to see whether there is spatial dispersal and adaptation of the virus and/or adaptation to crops...
February 6, 2018: Journal of Invertebrate Pathology
https://www.readbyqxmd.com/read/29425184/bioreducible-polymer-micelles-based-on-acid-degradable-poly-ethylene-glycol-poly-amino-ketal-enhance-the-stromal-cell-derived-factor-1%C3%AE-gene-transfection-efficacy-and-therapeutic-angiogenesis-of-human-adipose-derived-stem-cells
#18
Tae-Jin Lee, Min Suk Shim, Taekyung Yu, Kyunghee Choi, Dong-Ik Kim, Soo-Hong Lee, Suk Ho Bhang
Adipose-derived stem cells (ADSCs) have the potential to treat ischemic diseases. In general, ADSCs facilitate angiogenesis by secreting various pro-angiogenic growth factors. However, transplanted ADSCs have a low therapeutic efficacy in ischemic tissues due to their poor engraftment and low viability. Stromal cell-derived factor-1α (SDF-1α) improves the survival rate of stem cells transplanted into ischemic regions. In this study, we developed acid-degradable poly(ethylene glycol)-poly(amino ketal) (PEG-PAK)-based micelles for efficient intracellular delivery of SDF-1α plasmid DNA...
February 9, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29419444/impact-of-the-mitochondria-targeted-antioxidant-mitoq-on-hypoxia-induced-pulmonary-hypertension
#19
Oleg Pak, Susan Scheibe, Azadeh Esfandiary, Mareike Gierhardt, Akylbek Sydykov, Angela Logan, Athanasios Fysikopoulos, Florian Veit, Matthias Hecker, Florian Kroschel, Karin Quanz, Alexandra Erb, Katharina Schäfer, Mirja Fassbinder, Nasim Alebrahimdehkordi, Hossein A Ghofrani, Ralph T Schermuly, Ralf P Brandes, Werner Seeger, Michael P Murphy, Norbert Weissmann, Natascha Sommer
Increased mitochondrial reactive oxygen species (ROS), particularly superoxide have been suggested to mediate hypoxic pulmonary vasoconstriction (HPV), chronic hypoxia-induced pulmonary hypertension (PH) and right ventricular (RV) remodelling.We determined ROS in acute, chronic hypoxia and investigated the effect of the mitochondria-targeted antioxidant MitoQ under these conditions.The effect of MitoQ or its inactive carrier substance, decyltriphenylphosphonium (TPP+), on acute HPV (1% O2 for 10 minutes) was investigated in isolated blood-free perfused mouse lungs...
February 1, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29419334/survey-of-four-groups-of-cumulative-pesticide-residues-in-12-vegetables-in-15-provinces-in-china
#20
Xiaomin Xu, Lingyun Li, Xiaodong Huang, Huan Lin, Guangyang Liu, Donghui Xu, Jianhui Jiang
The present study investigated the concentrations of residues of four groups of pesticides in the People's Republic of China: organophosphorus, carbamate, pyrethroid, and triazine pesticides. Twenty-six pesticides were examined using gas chromatography-tandem mass spectrometry and liquid chromatography-tandem mass spectrometry in 2,169 samples of 12 typical vegetables collected from 15 provinces in China. The results showed that 908 (41.9%) samples were positive, with 133 (6.1%) samples exceeding the limit legal in China...
February 8, 2018: Journal of Food Protection
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