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https://www.readbyqxmd.com/read/27920252/group-i-paks-promote-skeletal-myoblast-differentiation-in-vivo-and-in-vitro
#1
Giselle A Joseph, Min Lu, Maria Radu, Jennifer K Lee, Steven J Burden, Jonathan Chernoff, Robert S Krauss
Skeletal myogenesis is regulated by signal transduction, but the factors and mechanisms involved are not well understood. The group I Paks, Pak1 and Pak2, are related protein kinases and direct effectors of Cdc42 and Rac1. Group I Paks are ubiquitously expressed and specifically required for myoblast fusion in Drosophila We report that both Pak1 and Pak2 are activated during mammalian myoblast differentiation. One pathway of activation is initiated by N-cadherin ligation, and involves the cadherin co-receptor Cdo with its downstream effector, Cdc42...
December 5, 2016: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/27919591/clonorchis-sinensis-excretory-secretory-products-regulate-migration-and-invasion-in-cholangiocarcinoma-cells-via-extracellular-signal-regulated-kinase-1-2-nuclear-factor-%C3%AE%C2%BAb-dependent-matrix-metalloproteinase-9-expression
#2
Jhang Ho Pak, Jimin Shin, In-Sung Song, Sungbo Shim, Sung-Wuk Jang
Matrix metalloproteinase-9 (MMP-9) plays an important role in the invasion and metastasis of various types of cancer cells. We have previously reported that excretory-secretory products (ESPs) from Clonorchis sinensis increases MMP-9 expression. However, the regulatory mechanisms through which MMP-9 expression affects cholangiocarcinoma development remain unclear. In the current study, we examined the potential role of ESPs in regulating the migration and invasion of various cholangiocarcinoma cell lines. We demonstrated that ESPs significantly induced MMP-9 expression and activity in a concentration-dependent manner...
December 2, 2016: International Journal for Parasitology
https://www.readbyqxmd.com/read/27912950/a-randomized-placebo-controlled-trial-of-traditional-chinese-medicine-as-an-add-on-therapy-to-oral-montelukast-in-the-treatment-of-mild-persistent-asthma-in-children
#3
Pak-Hong Chan, Ching-Yee To, Eric Yat-Tung Chan, Handong Li, Xiuxia Zhang, Pok-Yu Chow, Po-Ling Liu, Shuk-Yu Leung, Chung-Hong Chan, Ka-Yan Chan, Johnny Yick-Chun Chan, Jonathan Pak-Heng Ng, Daniel Kwok-Keung Ng
OBJECTIVES: Traditional Chinese medicine are commonly used for treatment of asthma. However, there are only very limited data about its efficacy in children. Therefore, we aimed to determine the efficacy of augmented Yu Ping Feng San (aYPFS) as an add-on to oral montelukast compared with montelukast alone for treatment of mild persistent asthma in children. DESIGN: A single centre, placebo-controlled, double-blinded, randomized control trial was carried out. Participants with age 6-18 years who had mild persistent asthma were randomized according to random number list to receive either aYPFS plus montelukast for 24 weeks or placebo plus montelukast for 24 weeks...
December 2016: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/27910566/hotspot-electron-temperature-from-x-ray-continuum-measurements-on-the-nif
#4
L C Jarrott, L R Benedetti, H Chen, N Izumi, S F Khan, T Ma, S R Nagel, O L Landen, A Pak, P K Patel, M Schneider, H A Scott
We report on measurements of the electron temperature in the hotspot of inertially confined, layered, spherical implosions on the National Ignition Facility using a differential filtering diagnostic. Measurements of the DT and DD ion temperatures using neutron time-of-flight detectors are complicated by the contribution of hot spot motion to the peak width, which produce an apparent temperature higher than the thermal temperature. The electron temperature is not sensitive to this non-thermal velocity and is thus a valuable input to interpreting the stagnated hot spot conditions...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910429/automated-analysis-of-hot-spot-x-ray-images-at-the-national-ignition-facility
#5
S F Khan, N Izumi, S Glenn, R Tommasini, L R Benedetti, T Ma, A Pak, G A Kyrala, P Springer, D K Bradley, R P J Town
At the National Ignition Facility, the symmetry of the hot spot of imploding capsules is diagnosed by imaging the emitted x-rays using gated cameras and image plates. The symmetry of an implosion is an important factor in the yield generated from the resulting fusion process. The x-ray images are analyzed by decomposing the image intensity contours into Fourier and Legendre modes. This paper focuses on the additional protocols for the time-integrated shape analysis from image plates. For implosions with temperatures above ∼4 keV, the hard x-ray background can be utilized to infer the temperature of the hot spot...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910406/comparison-of-implosion-core-metrics-a-10-ps-dilation-x-ray-imager-vs-a-100-ps-gated-microchannel-plate
#6
S R Nagel, L R Benedetti, D K Bradley, T J Hilsabeck, N Izumi, S Khan, G A Kyrala, T Ma, A Pak
The dilation x-ray imager (DIXI) [T. J. Hilsabeck et al., Rev. Sci. Instrum. 81, 10E317 (2010); S. R. Nagel et al., ibid. 83, 10E116 (2012); S. R. Nagel et al., ibid. 85, 11E504 (2014)] is a high-speed x-ray framing camera that uses the pulse-dilation technique to achieve a temporal resolution of less than 10 ps. This is a 10 × improvement over conventional framing cameras currently employed on the National Ignition Facility (NIF) (100 ps resolution), and otherwise only achievable with 1D streaked imaging...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910341/development-of-a-krypton-doped-gas-symmetry-capsule-platform-for-x-ray-spectroscopy-of-implosion-cores-on-the-nif
#7
T Ma, H Chen, P K Patel, M B Schneider, M A Barrios, D T Casey, H-K Chung, B A Hammel, L F Berzak Hopkins, L C Jarrott, S F Khan, B Lahmann, R Nora, M J Rosenberg, A Pak, S P Regan, H A Scott, H Sio, B K Spears, C R Weber
The electron temperature at stagnation of an ICF implosion can be measured from the emission spectrum of high-energy x-rays that pass through the cold material surrounding the hot stagnating core. Here we describe a platform developed on the National Ignition Facility where trace levels of a mid-Z dopant (krypton) are added to the fuel gas of a symcap (symmetry surrogate) implosion to allow for the use of x-ray spectroscopy of the krypton line emission.
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910336/high-intensity-laser-accelerated-ion-beam-produced-from-cryogenic-micro-jet-target
#8
M Gauthier, J B Kim, C B Curry, B Aurand, E J Gamboa, S Göde, C Goyon, A Hazi, S Kerr, A Pak, A Propp, B Ramakrishna, J Ruby, O Willi, G J Williams, C Rödel, S H Glenzer
We report on the successful operation of a newly developed cryogenic jet target at high intensity laser-irradiation. Using the frequency-doubled Titan short pulse laser system at Jupiter Laser Facility, Lawrence Livermore National Laboratory, we demonstrate the generation of a pure proton beam a with maximum energy of 2 MeV. Furthermore, we record a quasi-monoenergetic peak at 1.1 MeV in the proton spectrum emitted in the laser forward direction suggesting an alternative acceleration mechanism. Using a solid-density mixed hydrogen-deuterium target, we are also able to produce pure proton-deuteron ion beams...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27908797/molecular-detection-and-characterization-of-respiratory-syncytial-virus-b-genotypes-circulating-in-pakistani-children
#9
Uzma Bashir, Nadia Nisar, Nayab Mahmood, Muhammad Masroor Alam, Hajra Sadia, Syed Sohail Zahoor Zaidi
Respiratory syncytial virus (RSV) is the major cause of acute lower respiratory tract infections in young children, but very little is known about its epidemiology and circulating genotypes in Pakistan. This study analyzed the epidemiological and molecular characteristics of RSV B genotypes in Pakistani children below 5years with acute respiratory tract infections (ARIs) during three consecutive winter seasons from 2010 to 2013. A total of 1941 samples were analyzed for RSV infection by real time PCR and 24% (472/1941) samples were found positive out of which 22...
November 28, 2016: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/27907144/a-new-efficient-method-for-detecting-phase-singularity-in-cardiac-fibrillation
#10
Young-Seon Lee, Jun-Seop Song, Minki Hwang, Byounghyun Lim, Boyoung Joung, Hui-Nam Pak
BACKGROUND: The point of phase singularity (PS) is considered to represent a spiral wave core or a rotor in cardiac fibrillation. Computational efficiency is important for detection of PS in clinical electrophysiology. We developed a novel algorithm for highly efficient and robust detection of PS. METHODS: In contrast to the conventional method, which calculates PS based on the line integral of the phase around a PS point equal to ±2π (the Iyer-Gray method), the proposed algorithm (the location-centric method) looks for the phase discontinuity point at which PS actually occurs...
2016: PloS One
https://www.readbyqxmd.com/read/27905954/measuring-and-tracking-obesity-inequality-in-the-united-states-evidence-from-nhanes-1971-2014
#11
Tae-Young Pak, Susana Ferreira, Gregory Colson
BACKGROUND: Because people care about their weight relative to peers and society, obesity inequality plays a role in explaining obesity incidence and the impacts of being obese on subjective well-being. While the increase in obesity prevalence and mean body mass index (BMI) is well documented, the measurement of distributional changes and corresponding obesity inequality is yet to be fully explored. METHODS: The present study analyzed BMI data for adults aged 20 to 74 from the National Health and Nutritional Examination Survey (NHANES) I (1971-1974), II (1976-1980), III (1988-1994), and continuous NHANES (1999-2014)...
April 4, 2016: Population Health Metrics
https://www.readbyqxmd.com/read/27901621/perfluorooctanoic-acid-induces-mitochondrial-dysfunction-in-mc3t3-e1-osteoblast-cells
#12
Eun Mi Choi, Kwang Sik Suh, Sang Youl Rhee, Seungjoon Oh, Jeong-Taek Woo, Sung Woon Kim, Young Seol Kim, Youngmi Kim Pak, Suk Chon
Perfluorooctanoic acid (PFOA), a stable organic perfluorinated compound, is an emerging persistent organic pollutant, found widely in human and wildlife populations. Recent evidence suggests that exposure to environmental toxicants can be associated with higher risks of osteoporosis and fractures. We studied the cellular toxicology of PFOA in MC3T3-E1osteoblast cells. To examine the effect of PFOA, we measured cell viability, reactive oxygen species (ROS), mitochondrial superoxide, and mitochondrial parameters including adenosine triphosphate (ATP) level, mitochondrial membrane potential (MMP), cardiolipin content, and cytochrome c release in MC3T3-E1 cells...
November 30, 2016: Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering
https://www.readbyqxmd.com/read/27895114/in-vitro-and-clinical-evaluations-of-the-drug-drug-interaction-potential-of-a-metabotropic-glutamate-2-3-receptor-agonist-prodrug-at-pept1
#13
Y Anne Pak, Amanda J Long, William F Annes, Jennifer W Witcher, Mary Pat Knadler, Mosun A Ayan-Oshodi, Malcolm I Mitchell, Phillip Leese, Kathleen M Hillgren
Despite PEPT1 being responsible for the bioavailability for a variety of drugs, there has been little study of its potential involvement in drug-drug interactions. Pomaglumetad methionil, a metabotropic glutamate 2/3 receptor agonist prodrug, utilizes PEPT1 to enhance absorption and bioavailability. In vitro studies were conducted to guide the decision to conduct a clinical drug interaction study and to inform the clinical study design. In vitro investigations determined the prodrug (LY2140023 monohydrate) is a substrate of PEPT1 with Km value of approximately 30 μM, while the active moiety (LY404039) is not a PEPT1 substrate...
November 28, 2016: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/27893694/the-safety-and-efficacy-of-vitamin-k-antagonist-in-atrial-fibrillation-patients-with-previous-ulcer-bleeding-long-term-results-from-a-multicenter-study
#14
Seung-Jun Lee, Jung-Hoon Sung, Jin-Bae Kim, Min-Soo Ahn, Hye Young Lee, Jae-Sun Uhm, Hui-Nam Pak, Moon-Hyoung Lee, Jong-Yun Kim, Boyoung Joung
This study aimed to evaluate the safety and efficacy of vitamin K antagonist (VKA) in atrial fibrillation (AF) patients with previous ulcer bleeding.In this multicenter, retrospective analysis, clinical outcomes of 754 AF patients with a history of ulcer bleeding were evaluated. After ulcer treatment, 458 patients (61%) were treated with VKA, and the outcomes were compared to 296 patients (39%) without VKA.VKA treatment significantly increased major bleeding (7.3%/year vs 3.2%/year, P < 0.001), and reduced major adverse cardiac events (MACE) (5...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27893153/efficacy-and-safety-of-dabigatran-rivaroxaban-and-warfarin-for-stroke-prevention-in-chinese-patients-with-atrial-fibrillation-the-hong-kong-atrial-fibrillation-project
#15
Wen-Hua Li, Duo Huang, Chern-En Chiang, Chu-Pak Lau, Hung-Fat Tse, Esther W Chan, Ian C K Wong, Gregory Y H Lip, Pak-Hei Chan, Chung-Wah Siu
BACKGROUND: Little is known about the comparative effectiveness and safety of non-vitamin K antagonist oral anticoagulants (NOAC) compared to warfarin in Chinese atrial fibrillation (AF) patients. Our aim was to compare the ischemic stroke risk reduction and incidence of intracranial hemorrhage (ICH) of warfarin in relation to quality of anticoagulation control (as reflected by time in therapeutic range [TTR]), and to dabigatran and rivaroxaban in a real-world cohort of Chinese AF patients...
November 28, 2016: Clinical Cardiology
https://www.readbyqxmd.com/read/27881491/quantification-of-paclitaxel-and-polyaspartate-paclitaxel-conjugate-in-beagle-plasma-application-to-a-pharmacokinetic-study
#16
Yangyang Gao, Junying Chen, Xiqian Zhang, Huiru Xie, Yanran Wang, Shuquan Guo
An LC-MS/MS method for the determination of polyaspartate paclitaxel conjugate (PASP-PTX) and paclitaxel (PTX) in dog plasma with cephalomannine (Internal Standard for PASP-PTX, IS-I) and clopidogrel bisulfate (Internal Standard for PTX, IS-II) as the internal standards was developed and validated. Plasma samples of PASP-PTX were extracted by ethyl acetate following the hydrolysis reaction, while protein precipitation was used for the extraction of PTX using acetonitrile. Analytes were separated by a CAPCELL PAK C18 MG II column using a gradient elution with the mobile phase (A) 5 mM ammonium containing 0...
November 23, 2016: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/27879368/99mtc-duramycin-spect-imaging-of-early-tumor-response-to-targeted-therapy-a-comparison-with-18f-fdg-pet
#17
Filipe Elvas, Jan Boddaert, Christel Vangestel, Koon Pak, Brian Gray, Samir Kumar-Singh, Steven Staelens, Sigrid Stroobants, Leonie Wyffels
: Molecular imaging of cell death may provide a detailed readout of the cellular response to novel therapies and prognostic information on tumor treatment efficacy assisting in the design of individualized therapy. We compared the predictive power of cell death imaging using (99m)Tc-duramycin to current gold standard (18)F-FDG for treatment response evaluation after targeted therapy. METHODS: Early therapy response evaluation was assessed by (99m)Tc-duramycin SPECT and (18)F-FDG PET imaging in treatment-sensitive COLO205 and treatment-resistant HT29 human colorectal cancer xenografts 24 hours after a single dose of conatumumab or IgG1 control...
November 22, 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/27879173/residue-depletion-of-oxytetracycline-otc-and-4-epi-oxytetracycline-4-epi-otc-in-broiler-chicken-s-claws-by-liquid-chromatography-tandem-mass-spectrometry-lc-ms-ms
#18
J Cornejo, E Pokrant, D Araya, C Briceño, H Hidalgo, A Maddaleno, C Araya-Jordán, B San Martin
Antibiotics are widely used in poultry production for treatment of bacterial diseases. However, residues may remain in products and by-products destined for human consumption or animal feeding. The claws of chickens are a by-product from the poultry industry, which can directly or indirectly enter the food chain as meals destined to feed other productive animals. Thus, it becomes necessary to determine and quantify antimicrobial residues present in this matrix. The objective of the present study was to assess the depletion of oxytetracycline (OTC) and its metabolite 4-epi-OTC in broiler chicken's claws...
November 23, 2016: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/27876893/highly-bendable-in-ga-zno-thin-film-transistors-by-using-a-thermally-stable-organic-dielectric-layer
#19
Yogeenth Kumaresan, Yusin Pak, Namsoo Lim, Yonghun Kim, Min-Ji Park, Sung-Min Yoon, Hyoc-Min Youn, Heon Lee, Byoung Hun Lee, Gun Young Jung
Flexible In-Ga-ZnO (IGZO) thin film transistor (TFT) on a polyimide substrate is produced by employing a thermally stable SA7 organic material as the multi-functional barrier and dielectric layers. The IGZO channel layer was sputtered at Ar:O2 gas flow rate of 100:1 sccm and the fabricated TFT exhibited excellent transistor performances with a mobility of 15.67 cm(2)/Vs, a threshold voltage of 6.4 V and an on/off current ratio of 4.5 × 10(5). Further, high mechanical stability was achieved by the use of organic/inorganic stacking of dielectric and channel layers...
November 23, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27873497/high-prevalence-and-clinical-implication-of-myocardial-bridging-in-patients-with-early-repolarization
#20
Jiwon Seo, Junbeom Park, Jaewon Oh, Jae Sun Uhm, Jung Hoon Sung, Jong Youn Kim, Hui Nam Pak, Moon Hyoung Lee, Boyoung Joung
PURPOSE: Recent evidence suggests that early repolarization (ER) is related with myocardial ischemia. Compression of coronary artery by a myocardial bridging (MB) can be associated with clinical manifestations of myocardial ischemia. This study aimed to evaluate the associations of MB in patients with ER. MATERIALS AND METHODS: In consecutive patients (n=1303, age, 61±12 years) who had undergone coronary angiography, we assessed the prevalence and prognostic implication of MB in those with ER (n=142) and those without ER (n=1161)...
January 2017: Yonsei Medical Journal
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