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https://www.readbyqxmd.com/read/29454278/towards-a-better-understanding-on-mercury-adsorption-by-magnetic-bio-adsorbents-with-%C3%AE-fe-2-o-3-from-pinewood-sawdust-derived-hydrochar-influence-of-atmosphere-in-heat-treatment
#1
Huabin Wang, Yong Liu, Jerosha Ifthikar, Lerong Shi, Aimal Khan, Zhulei Chen, Zhuqi Chen
Pyrolysis under protective atmosphere was regarded as an indispensable process for the preparation of biomass-based adsorbents to achieve higher surface areas. In this paper, magnetic carbon composites (MCC) that fabricated under air atmosphere showed an adsorption capacity of 167.22 mg/g in 200 ppm Hg(II), which was significantly higher than magnetic biochar (MBC, 31.80 mg/g) that fabricated under traditional nitrogen protection, and this remarkable performance of MCC was consistent in a wide range of pHs...
February 6, 2018: Bioresource Technology
https://www.readbyqxmd.com/read/29453909/a-headspace-gas-chromatography-method-for-isopropanol-determination-in-warfarin-sodium-products-as-a-measure-of-drug-crystallinity
#2
Ziyaur Rahman, Sohail Akhtar, Akhtar Siddiqui, Anthony B Ciavarella, Agnes Nguyenpho, Patrick J Faustino, Mansoor A Khan
Coumadin® a nd s everal generic products of warfarin s odium (WS) contain the crystalline form (clathrate) in which WS and isopropanol (IPA) are associated in a 2:1 molar ratio. IPA is critical in maintaining the WS crystalline structure. Physicochemical properties of the drug and drug product may change when the crystalline drug transforms to amorphous form. A headspace-gas chromatography (HS-GC) method was developed and validated for IPA determination in the WS drug product. n-propanol (NPA) was used as internal standard and the method was validated for specificity, system suitability, linearity, accuracy, precision, range, limits of detection and quantification, and robustness...
March 1, 2018: Acta Pharmaceutica
https://www.readbyqxmd.com/read/29453904/synthesis-self-assembly-and-photoresponsive-liquid-crystals-based-on-azobenzene-derivatives
#3
Hongyan Wang, Yi Han, Wei Yuan, Mengjiao Wu, Yulan Chen
A new class of rod-coil-rod molecules with an azobenzene core were synthesized. They were found to form robust organogels in several kinds of organic solvents. Scanning electron microscopy (SEM), transmission electron microscopy (TEM), atomic force microscopy (AFM), FT-IR spectroscopy, UV-vis absorption spectroscopy, 1H NMR, and X-ray diffraction (XRD) revealed that in these organogels, the molecules self-assembled into nanofiber network with an H-type aggregation mode under the joint effect of Pi-Pi stacking, intermolecular hydrogen bonding, and van der Waals forces...
February 17, 2018: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/29453800/atomic-structures-of-corkscrew-forming-segments-of-sod1-reveal-varied-oligomer-conformations
#4
Smriti Sangwan, Michael R Sawaya, Kevin A Murray, MichaelP Hughes, David S Eisenberg
The aggregation cascade of disease-related amyloidogenic proteins, terminating in insoluble amyloid fibrils, involves intermediate oligomeric states. The structural and biochemical details of these oligomers have been largely unknown. Here we report crystal structures of variants of the cytotoxic oligomer-forming segment residues 28-38 of the ALS-linked protein, SOD1. The crystal structures reveal three different architectures: corkscrew oligomeric structure, non-twisting curved sheet structure and a steric zipper proto-filament structure...
February 17, 2018: Protein Science: a Publication of the Protein Society
https://www.readbyqxmd.com/read/29453740/arrestins-structural-disorder-creates-rich-functionality
#5
REVIEW
Vsevolod V Gurevich, Eugenia V Gurevich, Vladimir N Uversky
Arrestins are soluble relatively small 44-46 kDa proteins that specifically bind hundreds of active phosphorylated GPCRs and dozens of non-receptor partners. There are binding partners that demonstrate preference for each of the known arrestin conformations: free, receptor-bound, and microtubule-bound. Recent evidence suggests that conformational flexibility in every functional state is the defining characteristic of arrestins. Flexibility, or plasticity, of proteins is often described as structural disorder, in contrast to the fixed conformational order observed in high-resolution crystal structures...
February 16, 2018: Protein & Cell
https://www.readbyqxmd.com/read/29453450/insights-into-the-inhibitory-mechanisms-of-nadh-on-the-%C3%AE-%C3%AE-heterodimer-of-human-nad-dependent-isocitrate-dehydrogenase
#6
Yabing Liu, Lejia Hu, Tengfei Ma, Jun Yang, Jianping Ding
Human NAD-dependent isocitrate dehydrogenase (NAD-IDH) catalyzes the oxidative decarboxylation of isocitrate in the citric acid cycle. In the α 2 βγ heterotetramer of NAD-IDH, the γ subunit plays the regulatory role and the β subunit the structural role. Previous biochemical data have shown that mammalian NAD-IDHs can be inhibited by NADH; however, the molecular mechanism is unclear. In this work, we show that the αβ, αγ and α 2 βγ enzymes of human NAD-IDH can be inhibited by NADH, and further determine the crystal structure of the αγ heterodimer bound with an Mg 2+ and an NADH at the active site and an NADH at the allosteric site, which resembles that of the inactive α Mg γ heterodimer...
February 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29453376/high-quality-self-separated-gan-crystal-grown-on-a-novel-nanoporous-template-by-hvpe
#7
Qin Huo, Yongliang Shao, Yongzhong Wu, Baoguo Zhang, Haixiao Hu, Xiaopeng Hao
In this study, a novel nanoporous template was obtained by a two-step etching process from MOCVD-GaN/Al 2 O 3 (MGA) with electrochemical etching sequentially followed by chemical wet etching. The twice-etched MOCVD-GaN/Al 2 O 3 (TEMGA) templates were utilized to grow GaN crystals by hydride vapor phase epitaxy (HVPE) method. The GaN crystals were separated spontaneously from the TEMGA template with the assistance of voids formed by the etched nanopores. Several techniques were utilized to characterize the quality of the free-standing GaN crystals obtained from the TEMGA template...
February 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29453348/abcg2-contributes-to-the-development-of-gout-and-hyperuricemia-in-a-genome-wide-association-study
#8
Chung-Jen Chen, Chia-Chun Tseng, Jeng-Hsien Yen, Jan-Gowth Chang, Wen-Cheng Chou, Hou-Wei Chu, Shun-Jen Chang, Wei-Ting Liao
Although many genome-wide association studies (GWASs) of hyperuricemia or gout have been reported, the related genetic factors and the mechanisms from hyperuricemia to gouty attack remain unclear. This study aimed to identify genetic factors and pathogenesis of gout from hyperuricemia by genome-wide association study (GWAS). 747 gout patients, 747 hyperuricemia and 2071 age-matched controls were recruited and analyzed with Affymetrix 650 K chip to find the related genetic variants. The functions of the related genes were investigated in an endothelial cell (EC) with urate crystal stimulation...
February 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29453325/performance-of-the-2015-international-task-force-consensus-statement-risk-stratification-algorithm-for-implantable-cardioverter-defibrillator-placement-in-arrhythmogenic-right-ventricular-dysplasia-cardiomyopathy
#9
Gabriela M Orgeron, Anneline Te Riele, Crystal Tichnell, Weijia Wang, Brittney Murray, Aditya Bhonsale, Daniel P Judge, Ihab R Kamel, Stephan L Zimmerman, Harikrishna Tandri, Hugh Calkins, Cynthia A James
BACKGROUND: Ventricular arrhythmias are a feared complication of arrhythmogenic right ventricular dysplasia/cardiomyopathy. In 2015, an International Task Force Consensus Statement proposed a risk stratification algorithm for implantable cardioverter-defibrillator placement in arrhythmogenic right ventricular dysplasia/cardiomyopathy. METHODS AND RESULTS: To evaluate performance of the algorithm, 365 arrhythmogenic right ventricular dysplasia/cardiomyopathy patients were classified as having a Class I, IIa, IIb, or III indication per the algorithm at baseline...
February 2018: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/29453256/structural-characterization-and-directed-evolution-of-a-novel-acetyl-xylan-esterase-reveals-thermostability-determinants-of-the-carbohydrate-esterase-7-family
#10
Fiyinfoluwa A Adesioye, Thulani P Makhalanyane, Surendra Vikram, Bryan T Sewell, Wolf-Dieter Schubert, Don A Cowan
A hot desert hypolith metagenomic DNA sequence dataset was screened in-silico for genes annotated as acetyl xylan esterases (AcXEs). One of the genes identified encoded a ∼36 kDa protein (Axe1 NaM1 ). The synthesised gene was cloned, expressed and the resulting protein, purified. NaM1 was optimally active at pH 8.5 and 30°C, and functionally stable at salt concentrations up to 5 M. The specific activity and catalytic efficiency were 488.9 Umg -1 and 3.26x10 6 M -1 s -1 , respectively. The crystal structure of wild type NaM1 was solved at a resolution of 2...
February 16, 2018: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29453236/dnmt3a-dna-binding-residues-provide-specificity-for-cpg-dna-methylation
#11
(no author information available yet)
DNMT3A-DNMT3L-DNA crystal structures provide a mechanism for DNMT3A methyltransferase activity.
February 16, 2018: Cancer Discovery
https://www.readbyqxmd.com/read/29453229/crystal-structure-of-plant-legumain-reveals-a-unique-two-chain-state-with-ph-dependent-activity-regulation
#12
Florian B Zauner, Elfriede Dall, Christof Regl, Luigi Grassi, Chrisitian G Huber, Chiara Cabrele, Hans Brandstetter
The vacuolar cysteine protease legumain can cleave and selectively rebuild peptide bonds, thereby vastly expanding the sequential repertoire of biomolecules. In this context, plant legumains have recently at-tracted particular interest. Furthermore, legumains have important roles in many physiological pro-cesses, including programmed cell death. Their efficient peptide bond ligase activity has gained tremen-dous interest in the design of cyclic peptides for drug design. However, the mechanistic understanding of these dual activities is incomplete and partly conflicting...
February 16, 2018: Plant Cell
https://www.readbyqxmd.com/read/29453141/dft-td-dft-calculations-spectroscopic-characterizations-ftir-nmr-uv-vis-molecular-docking-and-enzyme-inhibition-study-of-7-benzoyloxycoumarin
#13
Mahboob Alam, Mohammad Jane Alam, Shaista Azaz, Mehtab Parveen, Soonheum Park, Shabbir Ahmad
The quantum chemical study, spectroscopic characterization and biological activity of the pharmaceutically active 7-benzoyloxycoumarin (2) molecule have been presented. Potential energy surface (PES) scanning has been performed to search for the most stable molecular geometry of the present compound. The stable geometry in the ground state, IR, UV-Vis absorption and NMR ( 13 C, 1 H) spectra of the title compound were theoretically obtained and compared with the experimental one. Various theoretical molecular parameters like molecular energy, atomic charges, dipole moment, thermodynamic parameters, donor-acceptor natural bond orbital (NBO) hyperconjugative interaction energies, frontier molecular orbitals energies, HOMO-LUMO gap, molecular electrostatic potential, chemical reactivity descriptors, molecular polarizability and non-linear optical (NLO) properties are presented...
February 8, 2018: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/29453135/dual-inhibitors-of-the-pro-survival-proteins-bcl-2-and-mcl-1-derived-from-natural-compound-meiogynin-a
#14
Alma Abou Samra, Aude Robert, Crystal Gov, Loëtitia Favre, Laure Eloy, Eric Jacquet, Jérôme Bignon, Joëlle Wiels, Sandy Desrat, Fanny Roussi
Thirty analogues of natural meiogynin A, a pan-Bcl-2 inhibitor, were prepared in order to elaborate cytotoxic compounds on specific cancer cells overexpressing one or more proteins of the Bcl-2 family. The interaction of all the new analogues with Bcl-xL, Mcl-1 and Bcl-2 proteins was first evaluated by fluorescence polarization assay (FPA) and showed that modulation of the lateral chain has a dramatic impact as subtle changes significantly modify the activity on the target proteins. The acetoxymethyl prodrugs of the two most active compounds were then elaborated to determine their cytotoxicity on B cell lines...
February 5, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29453122/assessment-of-the-potential-hazard-represented-by-natural-raw-materials-containing-mineral-fibres-the-case-of-the-feldspar-from-orani-sardinia-italy
#15
Alessandro F Gualtieri, Nicola Bursi Gandolfi, Simone Pollastri, Roberta Rinaldi, Orietta Sala, Giovanni Martinelli, Tiziana Bacci, Federica Paoli, Alberto Viani, Ruggero Vigliaturo
This work describes the nature of the potentially hazardous fibrous amphibole found in the Orani's feldspar mine (Sardinia, Italy). To identify its nature, a protocol of analysis including morphometric, chemical and crystallographic characterizations was applied. Thanks to this approach, it was possible to classify the observed fibres as tremolite after comparing chemical data, SEM/TEM observations, FTIR/ Raman spectra and X-ray diffraction data with those reported for a standard sample. The unit cell parameters of the investigated tremolite phase are a = 9...
February 7, 2018: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29453066/synthesis-of-a-stable-magnesium-impregnated-biochar-and-its-reduction-of-phosphorus-leaching-from-soil
#16
Qincheng Chen, Jiaolong Qin, Zhiwen Cheng, Lu Huang, Peng Sun, Lu Chen, Guoqing Shen
Biochar improves soil fertility and promotes long-term terrestrial carbon sequestration. However, biochar seems not to be stable enough due to physical, chemical and biological reactions. In this study, a novel, stable, and magnesium (Mg)-impregnated biochar was prepared from cow dung and applied to decrease P leaching from soil. XPS, FTIR, XRD, SEM and EDS were used to evaluate the effect of modification and phosphorus(P) sorption on the oxidation resistance of biochar. The results showed that the oxidation resistance of the Mg-impregnated biochar was improved by the formation of MgO on its surface...
February 9, 2018: Chemosphere
https://www.readbyqxmd.com/read/29453043/understanding-of-human-atp-binding-cassette-superfamily-and-novel-multidrug-resistance-modulators-to-overcome-mdr
#17
REVIEW
Imran Shair Mohammad, Wei He, Lifang Yin
Indeed, multi-drug resistance (MDR) is a significant obstacle to effective chemotherapy. The overexpression of ATP-binding cassette (ABC) membrane transporters is a principal cause of enhanced cytotoxic drug efflux and treatment failure in various types of cancers. At cellular level, the pumps of ABC family regulate the transportation of numerous substances including drugs in and out of the cells. In past, the overexpression of ABC pumps suggested a well-known mechanism of drug resistance in cancers as well as infectious diseases...
February 13, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29452304/the-chondrocyte-channelome-a-narrative-review
#18
Ali Mobasheri, Csaba Matta, Ilona Uzielienè, Emma Budd, Pablo Martín-Vasallo, Eiva Bernotiene
Chondrocytes are the main cells in the extracellular matrix of articular cartilage and possess a highly differentiated phenotype that is the hallmark of the unique physiological functions of this specialised load-bearing connective tissue. The plasma membrane of articular chondrocytes contains a rich and diverse complement of membrane proteins, known as the membranome, which defines the cell surface phenotype of the cells. The membranome is a key target of pharmacological agents and is important for chondrocyte function...
February 13, 2018: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/29452241/raw-material-variability-of-an-active-pharmaceutical-ingredient-and-its-relevance-for-processability-in-secondary-continuous-pharmaceutical-manufacturing
#19
F Stauffer, V Vanhoorne, G Pilcer, P-F Chavez, S Rome, M A Schubert, L Aerts, T De Beer
Active Pharmaceutical Ingredients (API) raw material variability is not always thoroughly considered during pharmaceutical process development, mainly due to low quantities of drug substance available. However, synthesis, crystallization routes and production sites evolve during product development and product life cycle leading to changes in physical material attributes which can potentially affect their processability. Recent literature highlights the need for a global approach to understand the link between material synthesis, material variability, process and product quality...
February 13, 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29452211/impact-of-change-of-matrix-crystallinity-and-polymorphism-on-ovalbumin-release-from-lipid-based-implants
#20
Luisa Duque, Martin Körber, Roland Bodmeier
The objectives of this study were to prepare lipid-based implants by hot melt extrusion (HME) for the prolonged release of ovalbumin (OVA), and to relate protein release to crystallinity and polymorphic changes of the lipid matrix. Two lipids, glycerol tristearate and hydrogenated palm oil, with different composition and degree of crystallinity were studied. Solid OVA was dispersed within the lipid matrixes and it preserved its stability during extrusion. This was partially attributed to a protective effect of the lipidic matrix...
February 13, 2018: European Journal of Pharmaceutical Sciences
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