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https://www.readbyqxmd.com/read/28550768/photochemical-studies-of-cis-ru-bpy-2-4-bzpy-co-pf6-2-and-cis-ru-bpy-2-4-bzpy-cl-pf6-blue-light-induced-nucleobase-binding
#1
Aurideia P de Sousa, Edinilton M Carvalho, Javier Ellena, Eduardo H S Sousa, Jackson R de Sousa, Luiz G F Lopes, Peter C Ford, Alda K M Holanda
The ruthenium(II) compounds cis-[Ru(bpy)2(4-bzpy)(CO)](PF6)2 (I) and cis-[Ru(bpy)2(4-bzpy)(Cl)](PF6) (II) (4-bzpy=4-benzoylpyridine, bpy=2,2'-bipyridine) were synthesized and characterized by spectroscopic and electrochemical techniques. The crystal structure of II was determined by X-ray diffraction. The photochemical behavior of I in aqueous solution shows that irradiation with ultraviolet light (365nm) releases both CO and 4-bzpy leading to the formation of the cis-[Ru(bpy)2(H2O)2](2+) ion as identified by NMR and electronic spectroscopy...
May 15, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28550353/health-policy-responsiveness-lessons-learned-from-maryland-and-prince-george-s-county
#2
Byron Sogie-Thomas, John Sankofa, Crystal Reed, Kweisi Mfume, Lauren Abla Doamekpor
Effective, timely, and intentional policy efforts can significantly impact and improve the public's health and reduce racial and ethnic health disparities across the nation. Creating and implementing responsive policies at the state and county level is essential to supporting community efforts to improve health behaviors and health outcomes, particularly for communities of color who bear the brunt of disease risk and negative health outcomes. Using policy examples from the State of Maryland and Prince George's County, the largest and wealthiest predominately African-American county in the USA, this case study highlights the importance of state and county policy action when presented with opportunities to affect long-lasting, positive change...
May 27, 2017: Journal of Racial and Ethnic Health Disparities
https://www.readbyqxmd.com/read/28550300/experimental-quantum-chemical-and-molecular-dynamic-simulations-studies-on-the-corrosion-inhibition-of-mild-steel-by-some-carbazole-derivatives
#3
Henry U Nwankwo, Lukman O Olasunkanmi, Eno E Ebenso
Five selected carbazole derivatives, namely carbazole, 3,6-dibromocarbazole, 2-hydroxycarbazole, 1,2,3,4-tetrahydrocarbazole and 9-(2-ethylhexyl)carbazole-3,6-dicarboxaldehyde were investigated for their inhibitive effects on Desulfovibrio vulgaris (D. vulgaris) induced corrosion of mild steel and in 1 M HCl medium using weight loss, potentiodynamic polarization and electrochemical impedance spectroscopy (EIS) techniques. The carbazole derivatives were found to be mixed type inhibitors with predominantly cathodic inhibitive effects for mild steel in 1 M HCl...
May 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28550118/s100a9-potentiates-the-activation-of-neutrophils-by-the-etiological-agent-of-gout-monosodium-urate-crystals
#4
Louis-Simon Rousseau, Guillaume Paré, Asmaa Lachhab, Paul H Naccache, François Marceau, Philippe Tessier, Martin Pelletier, Maria Fernandes
Gout is one of the most painful types of arthritis that arises when the body mounts an acute inflammatory reaction against a crystallized form of uric acid known as monosodium urate crystals (MSUs). Although MSUs are known to activate neutrophils, the most abundant leukocyte in the synovial fluid of patients with gout, few studies have investigated the effect on neutrophils of the simultaneous stimulation with MSU and proinflammatory mediators in the inflamed joint. Herein, we focused on a protein that is highly expressed in the synovium in gout, S100A9...
May 26, 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/28549919/microscopic-diffusion-in-hydrated-encysted-eggs-of-brine-shrimp
#5
E Mamontov
BACKGROUND: We have studied microscopic diffusion of water in fully hydrated encysted eggs of brine shrimp (Artemia). METHODS: We have utilized quasielastic neutron scattering. RESULTS: Dry eggs of brine shrimp were rehydrated using (1) water without additives, (2) eutectic mixture of water and dimethyl sulfoxide, and (3) a concentrated aqueous solution of lithium chloride. Despite the complexity of the hydrated multicellular organism, measurable microscopic diffusivity of water is rather well defined...
May 23, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28549686/pilonidal-sinus-disease-surgery-in-children-the-first-study-to-compare-crystallized-phenol-application-to-primary-excision-and-closure
#6
Ufuk Ates, Ergun Ergun, Gulnur Gollu, Sumeyye Sozduyar, Meltem Kologlu, Murat Cakmak, Huseyin Dindar, Aydin Yagmurlu
INTRODUCTION: Pilonidal sinus (PS) is an infectious and inflammatory disease of sacrococcygeal region. Current methods include; surgical excision with/without suturing the defect, rhomboid excision and flap and chemical substance application. In this study, crystallized phenol application was compared to excision and primary closure. PATIENTS AND METHODS: This retrospective study included pediatric patients with PS who were treated with excision and primer closure technique and phenol application...
May 16, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28549582/crystal-structure-of-spsb2-in-complex-with-a-rational-designed-rgd-containing-cyclic-peptide-inhibitor-of-spsb2-inos-interaction
#7
Tingting You, Yuhui Wang, Kefa Li, Danting Zhang, Huan Wei, Yanhong Luo, Hua Li, Yongzhi Lu, Xunchen Su, Zhihe Kuang
SPRY domain-containing SOCS box protein 2 (SPSB2) is a negative regulator of inducible nitric oxide synthase (iNOS) that modulates the lifetime of iNOS and thus the levels of nitric oxide (NO) production. Inhibitors that can disrupt the endogenous SPSB2-iNOS interaction and augment NO production have potential as novel antimicrobial and anticancer drugs. In this study, we have designed a cyclic peptide (cR8), containing an RGD motif and the SPSB2 binding motif (DINNNV). ITC and chemical shift perturbation showed that cR8 binds to the iNOS binding site on SPSB2 with a Kd of 671 nM, and saturation transfer difference NMR showed that cR8 binds to αvβ3 integrin-expressing cells...
May 23, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28549561/lateral-thalamic-control-of-nociceptive-response-after-whisker-pad-injection-of-varicella-zoster-virus
#8
Phillip Kramer, Crystal Stinson, Mikhail Umorin, Mohong Deng, Mahesh Rao, Larry Bellinger, Michael B Yee, Paul R Kinchington
Pain is a common complication of herpes zoster (HZ) infection which results from reactivation of a latent varicella zoster virus (VZV). A third of HZ patients' progress to a chronic pain state known as post herpetic neuralgia (PHN), and about a quarter of these patients' have orofacial pain. The mechanisms controlling the pain responses are not understood. Studies suggest central pathways involving the thalamus could control pain related to HZ, and studies in our lab suggest vesicular GABA transporter (VGAT) in the lateral thalamus influences orofacial pain...
May 23, 2017: Neuroscience
https://www.readbyqxmd.com/read/28549378/multi-layer-snse-nanoflake-field-effect-transistors-with-low-resistance-au-ohmic-contacts
#9
Sang-Hyeok Cho, Kwanghee Cho, No-Won Park, Soonyong Park, Jung-Hyuk Koh, Sang-Kwon Lee
We report p-type tin monoselenide (SnSe) single crystals, grown in double-sealed quartz ampoules using a modified Bridgman technique at 920 °C. X-ray powder diffraction (XRD) and energy dispersive X-ray spectroscopy (EDX) measurements clearly confirm that the grown SnSe consists of single-crystal SnSe. Electrical transport of multi-layer SnSe nanoflakes, which were prepared by exfoliation from bulk single crystals, was conducted using back-gated field-effect transistor (FET) structures with Au and Ti contacts on SiO2/Si substrates, revealing that multi-layer SnSe nanoflakes exhibit p-type semiconductor characteristics owing to the Sn vacancies on the surfaces of SnSe nanoflakes...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28549184/coiled-coil-interactions-mediate-serine-integrase-directionality
#10
Kushol Gupta, Robert Sharp, Jimmy B Yuan, Huiguang Li, Gregory D Van Duyne
Serine integrases are bacteriophage enzymes that carry out site-specific integration and excision of their viral genomes. The integration reaction is highly directional; recombination between the phage attachment site attP and the host attachment site attB to form the hybrid sites attL and attR is essentially irreversible. In a recent model, extended coiled-coil (CC) domains in the integrase subunits are proposed to interact in a way that favors the attPxattB reaction but inhibits the attLxattR reaction. Here, we show for the Listeria innocua integrase (LI Int) system that the CC domain promotes self-interaction in isolated Int and when Int is bound to attachment sites...
May 26, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28549094/a-novel-dominant-mutation-in-sag-the-arrestin-1-gene-is-a-common-cause-of-retinitis-pigmentosa-in-hispanic-families-in-the-southwestern-united-states
#11
Lori S Sullivan, Sara J Bowne, Daniel C Koboldt, Elizabeth L Cadena, John R Heckenlively, Kari E Branham, Dianna H Wheaton, Kaylie D Jones, Richard S Ruiz, Mark E Pennesi, Paul Yang, David Davis-Boozer, Hope Northrup, Vsevold V Gurevich, Rui Chen, Mingchu Xu, Yumei Li, David G Birch, Stephen P Daiger
Purpose: To identify the causes of autosomal dominant retinitis pigmentosa (adRP) in a cohort of families without mutations in known adRP genes and consequently to characterize a novel dominant-acting missense mutation in SAG. Methods: Patients underwent ophthalmologic testing and were screened for mutations using targeted-capture and whole-exome next-generation sequencing. Confirmation and additional screening were done by Sanger sequencing. Haplotypes segregating with the mutation were determined using short tandem repeat and single nucleotide variant polymorphisms...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28548877/role-of-osgin1-in-mediating-smoking-induced-autophagy-in-the-human-airway-epithelium
#12
Guoqing Wang, Haixia Zhou, Yael Strulovici-Barel, Mohammed Al-Hijji, Xuemei Ou, Jacqueline Salit, Matthew S Walters, Michelle R Staudt, Robert J Kaner, Ronald G Crystal
Enhanced macroautophagy/autophagy is recognized as a component of the pathogenesis of smoking-induced airway disease. Based on the knowledge that enhanced autophagy is linked to oxidative stress and the DNA damage response, both of which are linked to smoking, we used microarray analysis of the airway epithelium to identify smoking upregulated genes known to respond to oxidative stress and the DNA damage response. This analysis identified OSGIN1 (oxidative stress induced growth inhibitor 1) as significantly upregulated by smoking, in both the large and small airway epithelium, an observation confirmed by an independent small airway microarray cohort, TaqMan PCR of large and small airway samples and RNA-Seq of small airway samples...
May 26, 2017: Autophagy
https://www.readbyqxmd.com/read/28548861/emergent-optical-phononic-modes-upon-nanoscale-mesogenic-phase-transitions
#13
Dima Bolmatov, Mikhail Zhernenkov, Lewis Sharpnack, Dena M Agra-Kooijman, Satyendra Kumar, Alexey Suvorov, Ronald Pindak, Yong Q Cai, Alessandro Cunsolo
The investigation of phononic collective excitations in soft matter systems at the molecular scale has always been challenging due to limitations of experimental techniques in resolving low-energy modes. Recent advances in Inelastic X-ray Scattering (IXS) enabled the study of such systems with unprecedented spectral contrast at meV excitation energies. In particular, it has become possible to shed light on the low-energy collective motions in materials whose morphology and phase behavior can easily be manipulated, such as mesogenic systems...
May 26, 2017: Nano Letters
https://www.readbyqxmd.com/read/28548851/celastrofurans-a-g-dihydro-%C3%AE-agarofurans-from-the-australian-rainforest-vine-celastrus-subspicata-and-their-inhibitory-effect-on-leucine-transport-in-prostate-cancer-cells
#14
Mario Wibowo, Qian Wang, Jeff Holst, Jonathan M White, Andreas Hofmann, Rohan A Davis
Seven new dihydro-β-agarofurans, celastrofurans A-G (1-7), along with two known secondary metabolites, 9β-benzoyloxy-1α-furoyloxydihydro-β-agarofuran (8) and (1R,2R,4R,5S,7R,9S,10R)-2-acetoxy-9-benzoyloxy-1-furoyloxydihydro-β-agarofuran (9), were obtained from the leaves of the Australian rainforest vine, Celastrus subspicata. The structures of the new compounds were determined by detailed spectroscopic (1D/2D NMR) and MS data analysis. The absolute configurations of compounds 1-4 were defined by ECD and single-crystal X-ray diffraction studies...
May 26, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28548840/acceleration-of-crystal-growth-of-amorphous-griseofulvin-by-low-concentration-poly-ethylene-oxide-aspects-of-crystallization-kinetics-and-molecular-mobility
#15
Qin Shi, Chen Zhang, Yuan Su, Jie Zhang, Dongshan Zhou, Ting Cai
This study aims to investigate the crystallization behavior and molecular dynamics of amorphous griseofulvin (GSF) in the presence of low-concentration poly (ethylene oxide) (PEO). We observe that the addition of 3 % w/w PEO remarkably increases the crystal growth rate of GSF by two orders of magnitude, in both the supercooled liquid and glassy states. The liquid dynamics of amorphous GSF in the presence and absence of PEO are characterized by dielectric spectroscopy. With an increase of the PEO content, the α-relaxation times of the systems decrease, indicating the increase of global molecular mobility...
May 26, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28548830/stable-5-5%C3%A2-substituted-2-2%C3%A2-bipyrroles-building-blocks-for-macrocyclic-and-materials-chemistry
#16
Gonzalo Anguera, Brice Kauffmann, Jose Ignacio Borrell, Salvador Borros, David Sánchez-García
The preparation and characterization of a family of stable 2,2´-bipyrroles substituted at positions 5,5´with thienyl, phenyl, TMS-ethynyl, and vinyl groups is reported herein. The synthesis of these new bipyrroles comprises three steps: formation of the corresponding 5,5´-unsubstituted bipyrrole, bromination and Stille or Suzuki coupling. The best results in the coupling are obtained using the Stille reaction under microwave irradiation. The new compounds have been fully characterized by UV-vis absorption, fluorescence and IR spectroscopies and cyclic voltammetry...
May 26, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28548825/nepetaefolins-a-j-cytotoxic-chinane-and-abietane-diterpenoids-from-caryopteris-nepetaefolia
#17
Cheng-Gang Zhang, Gui-Xin Chou, Xu-Dong Mao, Qing-Shan Yang, Jian-Li Zhou
Nepetaefolins A-J (1-10) and seven known compounds were isolated from the whole plant of Caryopteris nepetaefolia. The absolute configurations of 1-3 were determined from single-crystal X-ray diffraction and spectroscopic data. Compounds 6 and 7, with IC50 values of 6.3-9.0 μM, showed higher cytotoxicity than paclitaxel in one non-small-cell lung cancer, patient-derived xenograft (PDX) model when tested using PDX models and the adenosine triphosphate-tumor chemosensitivity assay (ATP-TCA).
May 26, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28548818/pla-pbat-bionanocomposites-with-antimicrobial-natural-rosin-for-green-packaging
#18
Hesham Moustafa, Nadia El Kissi, Ahmed I Abou-Kandil, Mohamed S Abdel-Aziz, Alain Dufresne
The use of biodegradable polymers is of great importance nowadays in many applications. Some of the most commonly used biopolymers are polylactic acid (PLA) and poly(butylene adipate-co-terephthalate) (PBAT) due to their superior properties and availability. In this manuscript, we use a facile and green modification method of organoclay (OC) by antimicrobial natural rosin which is considered as a toxicity-free reinforcing material, thus keeping the green character of the material. It increases the interlayer spacing between the clay platelets...
May 26, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28548673/laser-triggered-phase-transition-in-photothermal-liquid-crystals
#19
Mathieu Ciancone, Franck Camerel
Reversible high temperature phase transitions were easily induced under laser irradiation in pure thermotropic liquid crystals built around photothermal nickel-bis(dithiolene) cores. The strong photothermal activity of nickel-bis(dithiolene) liquid crystalline thin films allows reaching a temperature as high as 250 °C directly from room temperature in a few seconds with high spatial control.
May 26, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28548520/oxysulfide-lialso-a-lithium-superionic-conductor-from-first-principles
#20
Xuelong Wang, Ruijuan Xiao, Hong Li, Liquan Chen
Through first-principles calculations and crystal structure prediction techniques, we identify a new layered oxysulfide LiAlSO in orthorhombic structure as a novel lithium superionic conductor. Two kinds of stacking sequences of layers of AlS_{2}O_{2} are found in different temperature ranges. Phonon and molecular dynamics simulations verify their dynamic stabilities, and wide band gaps up to 5.6 eV are found by electronic structure calculations. The lithium migration energy barrier simulations reveal the collective interstitial-host ion "kick-off" hopping mode with barriers lower than 50 meV as the dominating conduction mechanism for LiAlSO, indicating it to be a promising solid-state electrolyte in lithium secondary batteries with fast ionic conductivity and a wide electrochemical window...
May 12, 2017: Physical Review Letters
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