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Electrophysiology

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https://www.readbyqxmd.com/read/29166721/-a-preliminary-study-on-the-relationship-between-idiopathic-arrhythmia-and-cardiac-magnetic-resonance-imaging-defined-cardiac-features-in-patients-with-straight-back-syndrome
#1
L Chen, X H Ma, L Zhao, R Bai, S N Li, L Wang, H Chen, Z M Fan, M W Lou, Y D Niu
Objective: To retrospectively analyze the potential correlation between cardiac magnetic resonance (CMR) imaging and clinical features and idiopathic arrhythmia in patients with straight back syndrome (SBS). Methods: Patients receiving CMR imaging examination from April 2015 to March 2016 at our department (n=1 432) were screened, 76 patients met the diagnosis criteria of flat chest (anteroposterior diameter/transthoracic diameter (APD/TTD) ratio<0.37 at the T8 vertebra). After excluding 33 patients with structural heart disease, 43 SBS patients were divided into two groups: SBS without obvious morphological change in the heart (group A, n=19) and SBS with morphological change of the heart (group B, n=24)...
November 24, 2017: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/29166719/-clinical-characteristics-and-outcome-comparison-between-atrial-fibrillation-patients-underwent-catheter-ablation-under-general-aesthesia-or-local-anesthesia-and-sedation
#2
J J Xu, L J Gao, D Chang, X J Xiao, R F Zhang, J Lin, Z M Zhao, H Zhang, Y L Xia, X M Yin, Y Z Yang
Objective: To compare the outcome of radiofrequency catheter ablation under local anesthesia/sedation (S) or general anesthesia(GA) in atrial fibrillation patients. Methods: Data of 498 patients with atrial fibrillation undergoing radiofrequency catheter ablation in our departmentfrom January 2014 to December 2015 were retrospectively analyzed. Two hundred and twenty patients assigned to the GA group, the other 278 patients to the S group. Patients were followed clinically every 3 months within one year after procedure...
November 24, 2017: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/29166545/occurrence-of-primarily-noninducible-atrioventricular-nodal-reentry-tachycardia-after-radiofrequency-delivery-in-the-slow-pathway-region-during-empirical-slow-pathway-modulation
#3
Felix Konrad Wegner, Nils Bögeholz, Patrick Leitz, Gerrit Frommeyer, Dirk Georg Dechering, Simon Kochhäuser, Philipp Sebastian Lange, Julia Köbe, Kristina Wasmer, Gerold Mönnig, Lars Eckardt, Christian Pott
BACKGROUND: The first-line therapy for atrioventricular nodal reentry tachycardia (AVNRT) is catheter-based slow pathway modulation. If AVNRT is not inducible during an electrophysiological study, an empirical slow pathway modulation (ESPM) may be considered in patients with dual atrioventricular nodal physiology and/or a typical electrocardiogram (ECG). METHODS: We screened 149 symptomatic patients who underwent ESPM in our department between 1993 and 2013. All patients fulfilled the following criteria: (1) either dual atrioventricular nodal (AVN) physiology with up to 2 AVN echo beats or characteristic ECG documentation or both, (2) noninducibility of AVNRT by programmed stimulation, and (3) completion of a telephone questionnaire for long-term follow-up...
November 22, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/29165835/the-function-of-contactin-2-tag-1-in-oligodendrocytes-in-health-and-demyelinating-pathology
#4
Lida Zoupi, Maria Savvaki, Katerina Kalemaki, Ilias Kalafatakis, Kyriaki Sidiropoulou, Domna Karagogeos
The oligodendrocyte maturation process and the transition from the pre-myelinating to the myelinating state are extremely important during development and in pathology. In the present study, we have investigated the role of the cell adhesion molecule CNTN2/TAG-1 on oligodendrocyte proliferation, differentiation, myelination, and function during development and under pathological conditions. With the combination of in vivo, in vitro, ultrastructural, and electrophysiological methods, we have mapped the expression of CNTN2 protein in the oligodendrocyte lineage during the different stages of myelination and its involvement on oligodendrocyte maturation, branching, myelin-gene expression, myelination, and axonal function...
November 22, 2017: Glia
https://www.readbyqxmd.com/read/29165668/electrophysiological-measures-of-aging-pharynx-function-in-c-elegans-reveal-enhanced-organ-functionality-in-older-long-lived-mutants
#5
Joshua Coulter Russell, Nikolay Burnaevskiy, Bridget Ma, Miguel Arenas Mailig, Franklin Faust, Matt Crane, Matt Kaeberlein, Alexander Mendenhall
The function of the pharynx, an organ in the model system Caenorhabditis elegans, has been correlated with lifespan and motility (another measure of health) since 1980. In this study, in order to further understand the relationship between organ function and lifespan, we measured the age-related decline of the pharynx using an electrophysiological approach. We measured and analyzed electropharyngeograms of wild type animals, short-lived hsf-1 mutants, and long-lived animals with genetically decreased insulin signaling or increased heat shock pathway signaling; we recorded a total of 2,478 electropharyngeograms from 1,374 individuals...
November 18, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29165247/t2n-as-a-new-tool-for-robust-electrophysiological-modeling-demonstrated-for-mature-and-adult-born-dentate-granule-cells
#6
Marcel Beining, Lucas Alberto Mongiat, Stephan Wolfgang Schwarzacher, Hermann Cuntz, Peter Jedlicka
Compartmental models are the theoretical tool of choice for understanding single neuron computations. However, many models are incomplete, built ad hoc and require tuning for each novel condition rendering them of limited usability. Here, we present T2N, a powerful interface to control NEURON with Matlab and TREES toolbox, which supports generating models stable over a broad range of reconstructed and synthetic morphologies. We illustrate this for a novel, highly-detailed active model of dentate granule cells (GCs) replicating a wide palette of experiments from various labs...
November 22, 2017: ELife
https://www.readbyqxmd.com/read/29165241/lifting-the-veil-on-the-dynamics-of-neuronal-activities-evoked-by-transcranial-magnetic-stimulation
#7
Bingshuo Li, Juha P Virtanen, Axel Oeltermann, Cornelius Schwarz, Martin A Giese, Ulf Ziemann, Alia Benali
Transcranial magnetic stimulation (TMS) is a widely used non-invasive tool to study and modulate human brain functions. However, TMS-evoked activity of individual neurons has remained largely inaccessible due to the large TMS-induced electromagnetic fields. Here we present a general method providing direct in vivo electrophysiological access to TMS-evoked neuronal activity 0.8-1 ms after TMS onset. We translated human single-pulse TMS to rodents and unveiled time-grained evoked activities of motor cortex layer V neurons that show high-frequency spiking within the first 6 ms depending on TMS-induced current orientation and a multiphasic spike-rhythm alternating between excitation and inhibition in the 6-300 ms epoch, all of which can be linked to various human TMS responses recorded at the level of spinal cord and muscles...
November 22, 2017: ELife
https://www.readbyqxmd.com/read/29164611/serial-electrophysiology-in-guillain-barr%C3%A3-syndrome-a-retrospective-cohort-and-case-by-case-multicentre-analysis
#8
J Ibrahim, A-M Grapperon, F Manfredonia, P Y van den Bergh, S Attarian, Y A Rajabally
OBJECTIVES: To assess the usefulness of serial electrophysiology in Guillain-Barré syndrome (GBS) in a multicenter setting and the reasons for change in electrodiagnostic subtypes with serial studies. METHODS: We retrospectively analysed serial electrophysiology of 51 patients with GBS from 4 European centres. Proportions of subtypes were determined at each timing. Individual case analyses were also performed where diagnostic changes occurred with either criteria, to ascertain if changes were due to disease progression or criteria inadequacy...
November 21, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/29164430/eclalbasaponin-ii-ameliorates-the-cognitive-impairment-induced-by-cholinergic-blockade-in-mice
#9
Won Yong Jung, Haneul Kim, Se Jin Jeon, Hye Jin Park, Hyuck Jai Choi, Nam Jae Kim, Dong Hyun Kim, Dae Sik Jang, Jong Hoon Ryu
Eclalbasaponin II derived from Eclipta prostrata L. (Asteraceae) has been reported to have anti-fibrotic, anti-bacterial and autophagic activities, but its effect on cognitive function has not been investigated. We studied the effect of eclalbasaponin II on cholinergic blockade-induced memory impairment in mice using the passive avoidance, Y-maze, and Morris water maze tasks. Eclalbasaponin II (10 or 20 mg/kg, p.o.) significantly ameliorated the cognitive dysfunction induced by scopolamine in the passive avoidance, Y-maze, and the Morris water maze tasks...
November 21, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/29164035/a-clinical-practice-guideline-for-the-management-of-patients-with-degenerative-cervical-myelopathy-recommendations-for-patients-with-mild-moderate-and-severe-disease-and-nonmyelopathic-patients-with-evidence-of-cord-compression
#10
Michael G Fehlings, Lindsay A Tetreault, K Daniel Riew, James W Middleton, Bizhan Aarabi, Paul M Arnold, Darrel S Brodke, Anthony S Burns, Simon Carette, Robert Chen, Kazuhiro Chiba, Joseph R Dettori, Julio C Furlan, James S Harrop, Langston T Holly, Sukhvinder Kalsi-Ryan, Mark Kotter, Brian K Kwon, Allan R Martin, James Milligan, Hiroaki Nakashima, Narihito Nagoshi, John Rhee, Anoushka Singh, Andrea C Skelly, Sumeet Sodhi, Jefferson R Wilson, Albert Yee, Jeffrey C Wang
Study Design: Guideline development. Objectives: The objective of this study is to develop guidelines that outline how to best manage (1) patients with mild, moderate, and severe myelopathy and (2) nonmyelopathic patients with evidence of cord compression with or without clinical symptoms of radiculopathy. Methods: Five systematic reviews of the literature were conducted to synthesize evidence on disease natural history; risk factors of disease progression; the efficacy, effectiveness, and safety of nonoperative and surgical management; the impact of preoperative duration of symptoms and myelopathy severity on treatment outcomes; and the frequency, timing, and predictors of symptom development...
September 2017: Global Spine Journal
https://www.readbyqxmd.com/read/29163338/radial-peripapillary-capillary-network-in-patients-with-retinitis-pigmentosa-an-optical-coherence-tomography-angiography-study
#11
Rodolfo Mastropasqua, Enrico Borrelli, Luca Agnifili, Lisa Toto, Luca Di Antonio, Alfonso Senatore, Michele Palmieri, Alessandro D'Uffizi, Paolo Carpineto
Purpose: To investigate radial peripapillary capillary (RPC) network in patients affected by retinitis pigmentosa (RP). Methods: Eleven patients (22 eyes) with previous diagnosis of RP and 16 age-matched healthy subjects (16 eyes) were enrolled. The diagnosis of RP was made based on both clinical features and electrophysiological examination. All patients underwent a complete ophthalmologic examination, including optical coherence tomography angiography and visual field (VF)...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29163235/electrophysiological-anomalies-in-face-name-memory-encoding-in-young-binge-drinkers
#12
Rocío Folgueira-Ares, Fernando Cadaveira, Socorro Rodríguez Holguín, Eduardo López-Caneda, Alberto Crego, Paula Pazo-Álvarez
A growing body of evidence indicates that the intake of large amounts of alcohol during one session may have structural and functional effects on the still-maturing brains of young people. These effects are particularly pronounced in prefrontal and hippocampal regions, which appear to be especially sensitive to the neurotoxic effects of alcohol. However, to date, few studies have used the event-related potentials (ERPs) technique to analyze the relationship between binge drinking (BD) and associative memory...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29163226/adenosine-a2a-receptor-modulates-the-activity-of-globus-pallidus-neurons-in-rats
#13
Hui-Ling Diao, Yan Xue, Xiao-Hua Han, Shuang-Yan Wang, Cui Liu, Wen-Fang Chen, Lei Chen
The globus pallidus is a central nucleus in the basal ganglia motor control circuit. Morphological studies have revealed the expression of adenosine A2A receptors in the globus pallidus. To determine the modulation of adenosine A2A receptors on the activity of pallidal neurons in both normal and parkinsonian rats, in vivo electrophysiological and behavioral tests were performed in the present study. The extracellular single unit recordings showed that micro-pressure administration of adenosine A2A receptor agonist, CGS21680, regulated the pallidal firing activity...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29163220/evaluation-of-optogenetic-electrophysiology-tools-in-human-stem-cell-derived-cardiomyocytes
#14
Susann Björk, Elina A Ojala, Tommy Nordström, Antti Ahola, Mikko Liljeström, Jari Hyttinen, Esko Kankuri, Eero Mervaala
Current cardiac drug safety assessments focus on hERG channel block and QT prolongation for evaluating arrhythmic risks, whereas the optogenetic approach focuses on the action potential (AP) waveform generated by a monolayer of human cardiomyocytes beating synchronously, thus assessing the contribution of several ion channels on the overall drug effect. This novel tool provides arrhythmogenic sensitizing by light-induced pacing in combination with non-invasive, all-optical measurements of cardiomyocyte APs and will improve assessment of drug-induced electrophysiological aberrancies...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29163179/in-silico-assessment-of-efficacy-and-safety-of-ikur-inhibitors-in-chronic-atrial-fibrillation-role-of-kinetics-and-state-dependence-of-drug-binding
#15
Nicholas Ellinwood, Dobromir Dobrev, Stefano Morotti, Eleonora Grandi
Current pharmacological therapy against atrial fibrillation (AF), the most common cardiac arrhythmia, is limited by moderate efficacy and adverse side effects including ventricular proarrhythmia and organ toxicity. One way to circumvent the former is to target ion channels that are predominantly expressed in atria vs. ventricles, such as KV1.5, carrying the ultra-rapid delayed-rectifier K(+) current (IKur). Recently, we used an in silico strategy to define optimal KV1.5-targeting drug characteristics, including kinetics and state-dependent binding, that maximize AF-selectivity in human atrial cardiomyocytes in normal sinus rhythm (nSR)...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29163131/task-irrelevant-novel-sounds-have-antithetical-effects-on-visual-target-processing-in-young-and-old-adults
#16
Erich S Tusch, Nicole C Feng, Phillip J Holcomb, Kirk R Daffner
In young adults, primary visual task processing can be either enhanced or disrupted by novel auditory stimuli preceding target events, depending on task demands. Little is known about this phenomenon in older individuals, who, in general, are more susceptible to distraction. In the current study, age-related differences in the electrophysiological effects of task-irrelevant auditory stimuli on visual target processing were examined. Under both low and high primary task loads, the categorization/updating process in response to visual targets preceded by auditory novels, as indexed by the target P3 component, was enhanced in young, but diminished in old adults...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29163104/transcranial-random-noise-stimulation-does-not-improve-behavioral-and-neurophysiological-measures-in-patients-with-subacute-vegetative-unresponsive-wakefulness-state-vs-uws
#17
Mauro Mancuso, Laura Abbruzzese, Stefania Canova, Giulia Landi, Simone Rossi, Emiliano Santarnecchi
Background: The absence of efficient treatments capable to promote central nervous system recovery in patients in vegetative state (VS) due to a severe acquired brain injury highlights the need of exploring alternative neuromodulatory treatments that can lead to neurobehavioral gains. Some encouraging preliminary observations suggest that transcranial direct current stimulation could be effective in disorders of consciousness (DoC) patients, especially when applied on the dorsolateral prefrontal cortex (DLPFC) in patients with minimally conscious state (MCS) but not in those with VS...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29163087/localized-fluctuant-oscillatory-activity-by-working-memory-load-a-simultaneous-eeg-fmri-study
#18
Xiaojie Zhao, Xiaoyun Li, Li Yao
Working memory (WM) is a resource-limited memory system for temporary storage and processing of brain information during the execution of cognitive tasks. Increased WM load will increase the amount and difficulty of memory information. Several studies have used electroencephalography (EEG) or functional magnetic resonance imaging (fMRI) to explore load-dependent cognition processing according to the time courses of electrophysiological activity or the spatial pattern of blood oxygen metabolic activity. However, the relationships between these two activities and the underlying neural mechanism are still unclear...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/29163066/from-structure-to-behavior-in-basolateral-amygdala-hippocampus-circuits
#19
REVIEW
Ying Yang, Jian-Zhi Wang
Emotion influences various cognitive processes, including learning and memory. The amygdala is specialized for input and processing of emotion, while the hippocampus is essential for declarative or episodic memory. During emotional reactions, these two brain regions interact to translate the emotion into particular outcomes. Here, we briefly introduce the anatomy and functions of amygdala and hippocampus, and then present behavioral, electrophysiological, optogenetic and biochemical evidence from recent studies to illustrate how amygdala and hippocampus work synergistically to form long-term memory...
2017: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/29163058/adaptive-changes-in-the-vestibular-system-of-land-snail-to-a-30-day-spaceflight-and-readaptation-on-return-to-earth
#20
Nikolay Aseyev, Alia Kh Vinarskaya, Matvey Roshchin, Tatiana A Korshunova, Aleksey Yu Malyshev, Alena B Zuzina, Victor N Ierusalimsky, Maria S Lemak, Igor S Zakharov, Ivan A Novikov, Peter Kolosov, Ekaterina Chesnokova, Svetlana Volkova, Artem Kasianov, Leonid Uroshlev, Yekaterina Popova, Richard D Boyle, Pavel M Balaban
The vestibular system receives a permanent influence from gravity and reflexively controls equilibrium. If we assume gravity has remained constant during the species' evolution, will its sensory system adapt to abrupt loss of that force? We address this question in the land snail Helix lucorum exposed to 30 days of near weightlessness aboard the Bion-M1 satellite, and studied geotactic behavior of postflight snails, differential gene expressions in statocyst transcriptome, and electrophysiological responses of mechanoreceptors to applied tilts...
2017: Frontiers in Cellular Neuroscience
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