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https://www.readbyqxmd.com/read/29244831/antimicrobial-susceptibility-and-molecular-epidemiology-of-clinical-enterobacter-cloacae-bloodstream-isolates-in-shanghai-china
#1
Su Wang, Shu-Zhen Xiao, Fei-Fei Gu, Jin Tang, Xiao-Kui Guo, Yu-Xing Ni, Jie-Ming Qu, Li-Zhong Han
BACKGROUND: Enterobacter cloacae is a major nosocomial pathogen causing bloodstream infections. We retrospectively conducted a study to assess antimicrobial susceptibility and phylogenetic relationships of E. cloacae bloodstream isolates in two tertiary university-affiliated hospitals in Shanghai, in order to facilitate managements of E. cloacae bloodstream infections and highlight some unknowns for future prevention. METHODS: Fifty-three non-duplicate E. cloacae bloodstream isolates were consecutively collected from 2013 to 2016...
2017: PloS One
https://www.readbyqxmd.com/read/29244755/doped-halloysite-nanotubes-for-use-in-the-3d-printing-of-medical-devices
#2
Jeffery A Weisman, Udayabhanu Jammalamadaka, Karthik Tappa, David K Mills
Previous studies have established halloysite nanotubes (HNTs) as viable nanocontainers capable of sustained release of a variety of antibiotics, corrosion agents, chemotherapeutics and growth factors either from their lumen or in outer surface coatings. Accordingly, halloysite nanotubes (HNTs) hold great promise as drug delivery carriers in the fields of pharmaceutical science and regenerative medicine. This study explored the potential of 3D printing drug doped HNT constructs. We used a model drug, gentamicin (GS) and polylactic acid (PLA) to fabricate GS releasing disks, beads, and pellets...
December 15, 2017: Bioengineering
https://www.readbyqxmd.com/read/29244630/epidemiology-and-outcomes-of-bloodstream-infections-in-patients-with-solid-tumors-in-a-central-american-population-at-mexico-hospital-san-jose-costa-rica
#3
Jorge Calvo-Lon, Denis U Landaverde, Allan Ramos-Esquivel, Juan M Villalobos-Vindas
Purpose Bloodstream infections (BSIs) are an important cause of mortality in patients with solid tumors. We conducted a retrospective study to evaluate the epidemiologic profile and mortality of patients with solid tumors who have BSIs and were admitted to Mexico Hospital. This is the first study in Costa Rica and Central America describing the current epidemiologic situation. Methods We analyzed the infectious disease database for BSIs in patients with solid tumors admitted to Mexico Hospital from January 2012 to December 2014...
December 15, 2017: Journal of Global Oncology
https://www.readbyqxmd.com/read/29244123/emergence-and-genomic-analysis-of-mdr-laribacter-hongkongensis-strain-hlgz1-from-guangzhou-china
#4
Hong-Kai Wu, Jian-Huan Chen, Ling Yang, A-Rong Li, Dan-Hong Su, Yong-Ping Lin, Ding-Qiang Chen
Background: Laribacter hongkongensis is a facultative anaerobic, non-fermentative, Gram-negative bacillus associated with community-acquired gastroenteritis and traveller's diarrhoea. No clinical MDR L. hongkongensis isolate has been reported yet. Methods: We performed WGS (PacBio and Illumina) on a clinical L. hongkongensis strain HLGZ1 with an MDR phenotype. Results: HLGZ1 was resistant to eight classes of commonly used antibiotics. Its complete genome was a single circular chromosome of 3 424 272 bp with a G + C content of 62...
December 13, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29243921/extra-sugar-on-vancomycin-new-analogues-for-combating-multidrug-resistant-staphylococcus-aureus-and-vancomycin-resistant-enterococci
#5
Dongliang Guan, Feifei Chen, Lun Xiong, Feng Tang, Faridoon Faridoon, Yunguang Qiu, Naixia Zhang, Likun Gong, Jian Li, Lefu Lan, Wei Huang
Lipophilic substitution on vancomycin is an effective strategy for development of novel vancomycin analogues against drug-resistant bacteria by enhancing bacterial cell wall interaction. However, hydrophobic structures usually led to long elimination half-life and accumulative toxicity, therefore hydrophilic fragments were also introduced to the lipo-vancomycin to regulate their PK/PD properties. Here, we synthesized a series of new vancomycin analogues carrying various sugar moieties on the 7th-amino acid phenyl ring and lipophilic substitutions on vancosamine with extensive SAR analysis...
December 15, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29243909/optimization-of-coad-inhibitors-against-gram-negative-organisms-through-targeted-metabolomics
#6
Christopher M Rath, Bret M Benton, Javier De Vicente, Joseph E Drumm, Mei Geng, Cindy Li, Robert J Moreau, Xiaoyu Shen, Colin K Skepper, Micah Steffek, Kenneth Takeoka, Lisha Wang, Jun-Rong Wei, Wenjian Xu, Qiong Zhang, Brian Y Feng
Drug-resistant Gram-negative bacteria are of increasing concern worldwide. Novel antibiotics are needed, but their development is complicated by the requirement to simultaneously optimize molecules for target affinity and cellular potency, which can result in divergent structure-activity relationships (SARs). These challenges were exemplified during our attempts to optimize CoaD inhibitors identified through a biochemical screen. To facilitate lead optimization, we developed mass spectroscopy assays based on the hypothesis that levels of CoA metabolites would reflect the cellular enzymatic activity of CoaD...
December 15, 2017: ACS Infectious Diseases
https://www.readbyqxmd.com/read/29243494/does-subinhibitory-concentrations-of-clinically-important-antibiotic-induce-biofilm-production-of-enterococcus-faecium-strains
#7
Fatma Neslihan Yuksel, Neslihan Taskale Karatug, Mustafa Akcelik
Biofilm structures are the most resistant form of active microorganisms against sanitation, disinfection, and sterilization processes. One of the specific properties of biofilm is the development of antibiotic resistance that can be up to 1,000-fold greater than planktonic cells. Enterococcus faecium is a human pathogen that causes nosocomial bacteremia and at the present time, it is well known that most of the chronic infections are biofilm-based. Recent evidence suggested that subinhibitory concentrations (sub-MICs) of antibiotics have an important role in the evolution of antibiotic resistance and induction on biofilm formation...
December 15, 2017: Acta Microbiologica et Immunologica Hungarica
https://www.readbyqxmd.com/read/29243150/characterization-of-multiple-antibiotic-resistance-of-culturable-microorganisms-and-metagenomic-analysis-of-total-microbial-diversity-of-marine-fish-sold-in-retail-shops-in-mumbai-india
#8
Onkar A Naik, Ravindranath Shashidhar, Devashish Rath, Jayant R Bandekar, Archana Rath
Marine fish species were analyzed for culturable and total metagenomic microbial diversity, antibiotic resistance (AR) pattern, and horizontal gene transfer in culturable microorganisms. We observed a high AR microbial load of 3 to 4 log CFU g-1. Many fish pathogens like Providencia, Staphylococcus, Klebsiella pneumoniae, Enterobacter, Vagococcus, and Aeromonas veronii were isolated. Photobacterium and Vibrio were two major fish and human pathogens which were identified in the fish metagenome. Other pathogens that were identified were Shewanella, Acinetobacter, Psychrobacter, and Flavobacterium...
December 14, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29243060/synovial-aspiration-and-serological-testing-in-two-stage-revision-arthroplasty-for-prosthetic-joint-infection-evaluation-before-reconstruction-with-a-mean-follow-up-of-twenty%C3%A2-seven%C3%A2-months
#9
Heinrich M L Mühlhofer, C Knebel, Florian Pohlig, Susanne Feihl, Norbert Harrasser, Johannes Schauwecker, Rüdiger von Eisenhart-Rothe
INTRODUCTION: The two-stage revision protocol is the gold standard for controlling and treating low-grade prosthetic joint infections of total hip and total knee arthroplasty. The antibiotic pause for diagnostic reasons before reconstruction (stage two) is discussed in relation to the persistence of the infection and the development of resistant bacterial strains. Serological markers and a synovial analysis are commonly used to exclude the persistence of infection. Therefore, we asked (1) is the serological testing of C-reactive protein and leucocytes a valuable tool to predict a persistence of infection? and (2) what is the role of synovial aspiration of Plymethylmethacrylat (PMMA) spacers in hip and knee joints? MATERIALS AND METHODS: One hundred twelve patients who were MSIS criteria-positive for a prosthetic joint infection were studied, including 45 total hip arthroplasties (THA) and 67 total knee artrhoplasties (TKA) patients...
December 14, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/29242830/interaction-of-antibiotics-with-innate-host-defense-factors-against-salmonella-enterica-serotype-newport
#10
George Sakoulas, Monika Kumaraswamy, Armin Kousha, Victor Nizet
This study examines the pharmacodynamics of antimicrobials that are used to treat Salmonella with each other and with key components of the innate immune system. Antimicrobial synergy was assessed using time-kill and checkerboard assays. Antimicrobial interactions with innate immunity were studied by employing cathelicidin LL-37, whole-blood, and neutrophil killing assays. Ceftriaxone and ciprofloxacin were found to be synergistic in vitro against Salmonella enterica serotype Newport. Ceftriaxone, ciprofloxacin, and azithromycin each demonstrated synergy with the human cathelicidin defense peptide LL-37 in killing Salmonella...
November 2017: MSphere
https://www.readbyqxmd.com/read/29242803/as-a-definitive-choice-of-treatment-joint-and-defect-spanning-multiplanar-tubular-external-fixation-in-the-management-of-pediatric-open-defective-supracondylar-humerus-fracture-a-case-report
#11
Mehmet Demirel, Onur Tunali, Ismail Turkmen, Yavuz Saglam
Introduction: Although supracondylar fractures of the humerus are common in children, open fractures of are extremely rare injuries. Gustilo- Anderson Type-III fractures in the upper extremity are primarily associated with considerable bone loss resulting from high energy trauma. In this study, a case of open pediatric supracondylar humerus fracture treated by a joint and defect spanning multiplanar tubular external fixation is presented. Case Report: A boy aged 3 years suffered from a Gustilo-Anderson Type-IIIA supracondylar humerus fractures...
September 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/29241819/cyclophostin-and-cyclipostins-analogs-new-promising-molecules-to-treat-mycobacterial-related-diseases
#12
Phuong Chi Nguyen, Abdeldjalil Madani, Pierre Santucci, Benjamin P Martin, Rishi R Paudel, Sandrine Delattre, Jean-Louis Herrmann, Christopher D Spilling, Laurent Kremer, Stéphane Canaan, Jean-François Cavalier
The progression of mycobacterial diseases requires the development of new therapeutics. Here, we evaluated the efficacy and selectivity of a panel of Cyclophostin and Cyclipostins analogs (CyCs) against various bacteria and mycobacteria. The activity of these 26 CyCs was first assayed using the agar plate method. Compounds exhibiting a 50-100% growth inhibition rate were then selected to determine their MIC using the REMA assay. The best drug candidate was further tested against mycobacterial clinical isolates and bacteria responsible for nosocomial infections...
December 11, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29241766/integron-mediated-bacterial-resistance-and-virulence-on-clinical-pathogens
#13
Ding-Qiang Chen, Yue-Ting Jiang, Dong-Hua Feng, Shu-Xian Wen, Dan-Hong Su, Ling Yang
Integron was recognized as mobile elements responsible for the emergence and diffusion of antibiotic resistance, virulence and pathogenicity. The existence of resistant integron in pathogens may consequently lead to the increasing number of clinical failures in bacterial mediated diseases, as well as the expenses. In this study, a total of 22 clinical pathogens (including E. faecalis, S. aureus, K. pneumoniae, Enterobacter, P. aeruginosa and Acinetobacter) were subjected to the identification of class 1-class 3 integrons and drug resistant gene cassettes by high flux LAMP method...
December 11, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29241446/narrowing-the-spectrum-the-new-frontier-of-precision-antimicrobials
#14
Alexandra E Paharik, Henry L Schreiber, Caitlin N Spaulding, Karen W Dodson, Scott J Hultgren
Antibiotics have become the standard of care for bacterial infections. However, rising rates of antibiotic-resistant infections are outpacing the development of new antimicrobials. Broad-spectrum antibiotics also harm beneficial microbial communities inhabiting humans. To combat antibiotic resistance and protect these communities, new precision antimicrobials must be engineered to target specific pathogens.
December 14, 2017: Genome Medicine
https://www.readbyqxmd.com/read/29241413/novel-missense-mutations-in-gidb-gene-associated-with-streptomycin-resistance-in-mycobacterium-tuberculosis-insights-from-molecular-dynamics
#15
Bharati Pandey, Sonam Grover, Sukriti Goyal, Salma Jamal, Aditi Singh, Jagdeep Kaur, Abhinav Grover
Streptomycin was the first antibiotic used for the treatment of tuberculosis by inhibiting translational proof reading. Point mutation in gidB gene encoding S-adenosyl methionine (SAM)-dependent 7-methylguanosine (m7G) methyltransferase required for methylation of 16S rRNA confers streptomycin (STR) resistance. As there was no structural substantiation experimentally, gidB protein model was built by threading algorithm. In this work, molecular dynamics (MD) simulations coupled with binding free energy calculations were performed to outline the mechanism underlying high-level streptomycin resistance associated with three novel missense mutants including S70R, T146M and R187M...
December 14, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/29241300/prevalence-of-fluoroquinolone-resistant-rectal-flora-in-patients-undergoing-transrectal-ultrasound-guided-prostate-needle-biopsy-a-prospective-multicenter-study
#16
Ho Seok Chung, Eu Chang Hwang, Ho Song Yu, Seung Il Jung, Sun Ju Lee, Dong Hoon Lim, Won Jin Cho, Hyun Sop Choe, Seung-Ju Lee, Sung Woon Park
OBJECTIVES: To estimate the prevalence of fluoroquinolone-resistant rectal flora in patients undergoing transrectal ultrasound-guided prostate needle biopsy and to identify the high-risk groups. METHODS: From January 2015 to March 2016, rectal swabs of 557 men who underwent transrectal ultrasound-guided prostate needle biopsy were obtained from five institutions. Clinical variables, including demographics, rectal swab culture results and infectious complications, were evaluated...
December 14, 2017: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/29241213/antibiotics-induced-obesity-a-mitochondrial-perspective
#17
Melisa J Andrade, Chinchu Jayaprakash, Smitha Bhat, Nikolaos Evangelatos, Angela Brand, Kapaettu Satyamoorthy
Antibiotics are the first line of treatment against infections and have contributed immensely to reduce the morbidity and mortality rates. Recently, extensive use of antibiotics has led to alterations of the gut microbiome, predisposition to various diseases and most importantly, increase in the emergence of antibiotic-resistant bacteria, which poses a major threat to global public health. Another major issue faced worldwide due to unregulated use of antibiotics in children as well as in adults is the influence of metabolism and body weight homeostasis, leading to obesity...
December 15, 2017: Public Health Genomics
https://www.readbyqxmd.com/read/29241121/nanotitania-crystals-induced-efficient-photocatalytic-color-degradation-antimicrobial-and-larvicidal-activity
#18
Jinu Udayabhanu, Vaitheeswari Kannan, Manish Tiwari, Geetha Natesan, Benelli Giovanni, Venkatachalam Perumal
Textile industries release tonnes of harmful toxic dyes into the environment, causing severe effects on living organisms, including humans. Mosquitoes vectors spread important diseases which cause millions of human deaths worldwide. To control mosquitoes a number of synthetic mosquitocidal agents have been employed but all these pesticides pose harmful effects to human health and non-target species and also led to resistance development in treated vectors. Microbial strains are also developing resistance to the available antibiotics, this currently represents a major public health challenge...
December 6, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29240786/time-trend-analysis-2009-2016-of-antimicrobial-susceptibility-in-neisseria-gonorrhoeae-isolated-in-italy-following-the-introduction-of-the-combined-antimicrobial-therapy
#19
Paola Stefanelli, Maria Fenicia Vescio, Maria Paola Landini, Ivano Dal Conte, Alberto Matteelli, Antonio Cristaudo, Marina Gaino, Marco Cusini, Anna Maria Barbui, Antonella Mencacci, Rosella De Nittis, Valeria Ghisetti, Elena Stroppiana, Anna Carannante
INTRODUCTION: Neisseria gonorrhoeae (NG) antimicrobial susceptibility trends to azithromycin, cefixime and ceftriaxone were analyzed, from 2009 to 2016, to monitor changing antimicrobial susceptibility concomitant with the change in prescribing practice in 2012 from cefixime, or ceftriaxone, to ceftriaxone plus azithromycin. Patient characteristics predictive to be infected by antibiotic resistant N. gonorrhoeae were estimated. Finally, the protocol for the treatment of gonorrhoea, in comparison with the international guidelines, was also evaluated...
2017: PloS One
https://www.readbyqxmd.com/read/29240717/a-novel-antibiotic-mechanism-of-l-cyclopropylalanine-blocking-the-biosynthetic-pathway-of-essential-amino-acid-l-leucine
#20
Bingji Ma, Jinwen Shen, Wandee Yindeeyoungyeon, Yuan Ruan
The unusual amino acid l-cyclopropylalanine was isolated from the mushroom Amanita virgineoides after detection in an anti-fungal screening test. l-Cyclopropylalanine was found to exhibit broad-spectrum inhibition against fungi and bacteria. The anti-fungal activity was found to be abolished in the presence of the amino acid l-leucine, but not any other amino acids, indicating that l-cyclopropylalanine may block the biosynthesis of the essential amino acid l-leucine, thereby inhibiting fungal and bacteria growth...
December 14, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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