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https://www.readbyqxmd.com/read/29682513/lung-cancer-stem-cells-origin-characteristics-and-therapy
#1
REVIEW
D Prabavathy, Y Swarnalatha, Niveditha Ramadoss
Cancer stem cells (CSCs) have gained an increasing attention recently in cancer research. CSCs have ability to generate new tumor through their stem cell properties, essentially self-renewal potential and differentiation into multiple cell lineages. Extensive evidences report that CSCs are resistant to many conventional therapies and mediate tumor recurrence. CSCs of lung cancer are well recognized by their specific markers such as CD133, CD44, ABCG2 and ALDH1A1 together with the CSC characteristics including spheroid and colony formation...
2018: Stem Cell Investigation
https://www.readbyqxmd.com/read/29682512/targeting-notch-signalling-pathway-of-cancer-stem-cells
#2
REVIEW
Vandana Venkatesh, Raghu Nataraj, Gopenath S Thangaraj, Murugesan Karthikeyan, Ashok Gnanasekaran, Shanmukhappa B Kaginelli, Gobianand Kuppanna, Chandrashekrappa Gowdru Kallappa, Kanthesh M Basalingappa
Cancer stem cells (CSCs) have been defined as cells within tumor that possess the capacity to self-renew and to cause the heterogeneous lineages of cancer cells that comprise the tumor. CSCs have been increasingly identified in blood cancer, prostate, ovarian, lung, melanoma, pancreatic, colon, brain and many more malignancies. CSCs have slow growth rate and are resistant to chemotherapy and radiotherapy that lead to the failure of traditional current therapy. Eradicating the CSCs and recurrence, is promising aspect for the cure of cancer...
2018: Stem Cell Investigation
https://www.readbyqxmd.com/read/29681568/microrna-208a-regulates-h9c2-cells-simulated-ischemia-reperfusion-myocardial-injury-via-targeting-chd9-through-notch-nf-kappa-b-signal-pathways
#3
Shouwen Zhang, Rongjun Zhang, Fangfang Wu, Xinhua Li
Ischemic reperfusion (I/R) injury is a serious problem in the treatment of ischemic heart disease. MicroRNA-208a (miR-208a) is a cardiac-specific or cardiac-enriched miRNA. This study was aimed to assess the role of miR-208a in I/R injury. H9c2 cells were used to simulate I/R injury in vitro. miR-208a expression level was measured by qPCR. H9c2 cells after simulated I/R injury were transfected with miR-208a mimic, AOS-miR-208a or negative controls. LDH release, MDA and SOD contents were measured by corresponding purchased detection kits, respectively...
April 20, 2018: International Heart Journal
https://www.readbyqxmd.com/read/29681543/the-pou-oct-transcription-factor-nubbin-controls-the-balance-of-intestinal-stem-cell-maintenance-and-differentiation-by-isoform-specific-regulation
#4
Xiongzhuo Tang, Yunpo Zhao, Nicolas Buchon, Ylva Engström
Drosophila POU/Oct transcription factors are required for many developmental processes, but their putative regulation of adult stem cell activity has not been investigated. Here, we show that Nubbin (Nub)/Pdm1, homologous to mammalian OCT1/POU2F1 and related to OCT4/POU5F1, is expressed in gut epithelium progenitor cells. We demonstrate that the nub-encoded protein isoforms, Nub-PB and Nub-PD, play opposite roles in the regulation of intestinal stem cell (ISC) maintenance and differentiation. Depletion of Nub-PB in progenitor cells increased ISC proliferation by derepression of escargot expression...
April 17, 2018: Stem Cell Reports
https://www.readbyqxmd.com/read/29680697/regeneration-of-cochlear-hair-cells-and-hearing-recovery-through-hes1-modulation-with-sirna-nanoparticles-in-adult-guinea-pigs
#5
Xiaoping Du, Qunfeng Cai, Matthew B West, Ibrahima Youm, Xiangping Huang, Wei Li, Weihua Cheng, Don Nakmali, Donald L Ewert, Richard D Kopke
Deafness is commonly caused by the irreversible loss of mammalian cochlear hair cells (HCs) due to noise trauma, toxins, or infections. We previously demonstrated that small interfering RNAs (siRNAs) directed against the Notch pathway gene, hairy and enhancer of split 1 (Hes1), encapsulated within biocompatible poly(lactic-co-glycolic acid) nanoparticles (PLGA NPs) could regenerate HCs within ototoxin-ablated murine organotypic cultures. In the present study, we delivered this sustained-release formulation of Hes1 siRNA (siHes1) into the cochleae of noise-injured adult guinea pigs...
March 10, 2018: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/29680335/the-sigmoid-notch-view-for-distal-radius-fractures
#6
Robin N Kamal, Fraser Leversedge, David S Ruch, Suhail K Mithani, Ilvy H F Cotterell, Marc J Richard
PURPOSE: This study defines the sigmoid notch view of the distal radius. Specifically, we tested the null hypothesis that there is no relationship between the subchondral stripe of bone seen on a sigmoid notch view of the distal radius and the articular surface of the sigmoid notch. METHODS: We used 44 wrist specimens for anatomic and fluoroscopic analysis. We measured the articular depth of the sigmoid notch from its deepest point and classified the shape of the sigmoid notch...
April 18, 2018: Journal of Hand Surgery
https://www.readbyqxmd.com/read/29680270/regulation-of-cancer-cell-signaling-pathways-by-mushrooms-and-their-bioactive-molecules-overview-of-the-journey-from-benchtop-to-clinical-trials
#7
Aliye Aras, Sumbul Khalid, Saima Jabeen, Ammad Ahmad Farooqi, Baojun Xu
Mushrooms represent a tremendous source of biologically useful and pharmacologically active molecules. Recent breakthroughs in cancer genetics, genomics, proteomics and translational research have helped us to develop a better understanding of the underlying mechanisms which are contributory in cancer development and progression. Different signaling pathways particularly, Wnt, SHH, TGF/SMAD and JAK/STAT have been shown to modulate cancer progression and development. Increasingly it is being realized that genetic/epigenetic mutations and loss of apoptosis also mandate a 'multi-molecular' perspective for the development of therapies to treat cancer...
April 19, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29679270/mutagenic-assessment-of-lithobates-catesbeianus-tadpoles-exposed-to-the-2-4-d-herbicide-in-a-simulated-realistic-scenario
#8
Carlos Mesak, Bruna de Oliveira Mendes, Raíssa de Oliveira Ferreira, Guilherme Malafaia
The aim of the current study is to assess possible erythrocyte mutagenic effects on Lithobates catesbeianus tadpoles exposed to water contaminated with 2,4-D. In order to do so, tadpoles were exposed to a predictive and environmentally relevant herbicide concentration (1.97 mg/L), which is likely to be found in lentic environments formed by superficial water runoffs in pasture areas where the herbicide was applied. The micronucleus test, as well as tests for other nuclear abnormalities, was conducted after 3, 5, and 9 days of exposure (d...
April 20, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29679159/notch-1-sirna-and-methotrexate-towards-a-multifunctional-approach-in-rhematoid-arthritis-management-a-nanomedicine-approach
#9
Guang Zhao, Haifei Zhang
PURPOSE: Rheumatoid arthritis (RA) is a chronic inflammatory disease and Notch pathway plays a pivotal role in synoviocytes involved in progression of RA. METHODS: Herein, we have designed a self-assembled polymeric micelles based on polycaprolactone-polyethylene glycol (PCL-PEG) and polyethylenimine-polyethylene glycol (PEI-PEG) was prepared and loaded with methotrexate and Notch-1 siRNA for the effective treatment of rheumatoid arthritis. RESULTS: The MTX/siRNA-loaded polymeric micelles (siM-PM) showed appreciable cellular uptake in Raw264...
April 20, 2018: Pharmaceutical Research
https://www.readbyqxmd.com/read/29679117/the-infrapatellar-fat-pad-is-a-dynamic-and-mobile-structure-which-deforms-during-knee-motion-and-has-proximal-extensions-which-wrap-around-the-patella
#10
Joanna M Stephen, Ran Sopher, Sebastian Tullie, Andrew A Amis, Simon Ball, Andy Williams
PURPOSE: The infrapatellar fat pad (IFP) is a common cause of knee pain and loss of knee flexion and extension. However, its anatomy and behavior are not consistently defined. METHODS: Thirty-six unpaired fresh frozen knees (median age 34 years, range 21-68) were dissected, and IFP attachments and volume measured. The rectus femoris was elevated, suprapatellar pouch opened and videos recorded looking inferiorly along the femoral shaft at the IFP as the knee was flexed...
April 20, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29678815/feedback-between-tissue-packing-and-neurogenesis-in-the-zebrafish-neural-tube
#11
Tom W Hiscock, Joel B Miesfeld, Kishore R Mosaliganti, Brian A Link, Sean G Megason
Balancing the rate of differentiation and proliferation in developing tissues is essential to produce organs of robust size and composition. Whilst many molecular regulators have been established, how these connect to physical and geometrical aspects of tissue architecture is poorly understood. Here, using high-resolution timelapse imaging, we find that changes to cell geometry associated with dense tissue packing play a significant role in regulating differentiation rate in the zebrafish neural tube. Specifically, progenitors that are displaced away from the apical surface due to crowding tend to differentiate, in a Notch-dependent manner...
April 20, 2018: Development
https://www.readbyqxmd.com/read/29678170/self-reported-functional-recovery-after-reconstruction-versus-repair-in-acute-anterior-cruciate-ligament-rupture-rotor-a-randomized-controlled-clinical-trial
#12
Barbara C Boer, Roy A G Hoogeslag, Reinoud W Brouwer, Anna Demmer, Rianne M H A Huis In 't Veld
BACKGROUND: Anterior cruciate ligament (ACL) reconstruction is today's surgical gold standard for ACL rupture. Although it provides satisfactory results, not all patients return to their previous activity level and moreover, early posttraumatic osteoarthritis is not prevented. As such, a renewed interest has emerged in ACL suture repair combined with dynamic augmentation. Compared to ACL reconstruction, the hypothesized advantages of ACL suture repair are earlier return to sports, reduction of early posttraumatic osteoarthritis and preservation of the patient's native ACL tissue and proprioceptive envelope of the knee...
April 20, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29678138/an-anthropometric-study-of-distal-tibiofibular-syndesmosis-dts-in-a-chinese-population
#13
Mingyang Yu, Yao Zhang, Yun Su, Feng Wang, Dewei Zhao
BACKGROUND: To improve the diagnostic accuracy of distal tibiofibular syndesmoses (DTS), this study quantified the range in variations of the normal DTS in a Chinese population, based on CT scan images. METHODS: The study population comprised 92 patients with unilateral ankle injury. CT scans included the non-injured contralateral DTS. The position of the fibula relative to the fibular notch (incisure) of the tibia was quantified by inclusion or separation indices, based on whether the fibula was within or outside the fibular incisure, respectively...
April 20, 2018: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29677185/patterning-mechanisms-diversify-neuroepithelial-domains-in-the-drosophila-optic-placode
#14
Abhishek Kumar Mishra, F Javier Bernardo-Garcia, Cornelia Fritsch, Tim-Henning Humberg, Boris Egger, Simon G Sprecher
The central nervous system develops from monolayered neuroepithelial sheets. In a first step patterning mechanisms subdivide the seemingly uniform epithelia into domains allowing an increase of neuronal diversity in a tightly controlled spatial and temporal manner. In Drosophila, neuroepithelial patterning of the embryonic optic placode gives rise to the larval eye primordium, consisting of two photoreceptor (PR) precursor types (primary and secondary), as well as the optic lobe primordium, which during larval and pupal stages develops into the prominent optic ganglia...
April 20, 2018: PLoS Genetics
https://www.readbyqxmd.com/read/29676975/eighteen-month-clinical-study-of-universal-adhesives-in-noncarious-cervical-lesions
#15
V C Ruschel, S Shibata, S C Stolf, Y Chung, L N Baratieri, H O Heymann, R Walter
OBJECTIVE: To evaluate the clinical performance of Scotchbond Universal (3M Oral Care) and Prime & Bond Elect (Dentsply Sirona) in the restoration of noncarious cervical lesions (NCCLs). METHODS AND MATERIALS: This was a randomized controlled clinical trial involving 63 subjects. Two hundred and three NCCLs were restored using Scotchbond Universal and Prime & Bond Elect using both an etch-and-rinse and a self-etch technique. Lesions were notch-shaped NCCLs, and the restorations were placed without any mechanical retention...
May 2018: Operative Dentistry
https://www.readbyqxmd.com/read/29674611/inhibition-of-dll4-notch1-pathway-promotes-angiogenesis-of-masquelet-s-induced-membrane-in-rats
#16
Qian Tang, Haimin Jin, Minji Tong, Gang Zheng, Zhongjie Xie, Shangkun Tang, Jialei Jin, Ping Shang, Huazi Xu, Liyan Shen, Yu Zhang, Haixiao Liu
The Masquelet's induced membrane technique for repairing bone defects has been demonstrated to be a promising treatment strategy. Previous studies have shown that the vessel density of induced membrane is decreased in the late stage of membrane formation, which consequently disrupts the bone healing process. However, relatively little is known about certain mechanisms of vessel degeneration in the induced membrane tissue and whether promotion of angiogenesis in induced membranes can improve bone regeneration...
April 20, 2018: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/29673221/key-processes-of-silicon-on-glass-mems-fabrication-technology-for-gyroscope-application
#17
Zhibo Ma, Yinan Wang, Qiang Shen, Han Zhang, Xuetao Guo
MEMS fabrication that is based on the silicon-on-glass (SOG) process requires many steps, including patterning, anodic bonding, deep reactive ion etching (DRIE), and chemical mechanical polishing (CMP). The effects of the process parameters of CMP and DRIE are investigated in this study. The process parameters of CMP, such as abrasive size, load pressure, and pH value of SF1 solution are examined to optimize the total thickness variation in the structure and the surface quality. The ratio of etching and passivation cycle time and the process pressure are also adjusted to achieve satisfactory performance during DRIE...
April 17, 2018: Sensors
https://www.readbyqxmd.com/read/29672434/assessment-of-cartilage-growth-after-biopsy-of-osteochondral-loose-bodies-in-adolescent-knees-for-use-in-autologous-chondrocyte-implantation
#18
Sean Robinson, Jonathan Kramer, Trevor Shelton, Jarrad Merriman, Brian Haus
BACKGROUND: The goal of this study is to determine whether harvested cartilage from an osteochondral loose body maintains the same viability for implantation as cartilage harvested from the traditional locations within the adolescent knee for autologous chondrocyte implantation (ACI). METHODS: A retrospective study was performed on all ACI procedures performed from 2014 to 2017 at a single institution. Biopsies were derived from 2 groups: osteochondral loose body verses the intercondylar notch...
April 18, 2018: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/29668883/deletion-of-delta-like-1-homologue-accelerates-fibroblast-myofibroblast-differentiation-and-induces-myocardial-fibrosis
#19
Patricia Rodriguez, Yassine Sassi, Luca Troncone, Ludovic Benard, Kiyotake Ishikawa, Ronald E Gordon, Santiago Lamas, Jorge Laborda, Roger J Hajjar, Djamel Lebeche
Aims: Myocardial fibrosis is associated with profound changes in ventricular architecture and geometry, resulting in diminished cardiac function. There is currently no information on the role of the delta-like homologue 1 (Dlk1) in the regulation of the fibrotic response. Here, we investigated whether Dlk1 is involved in cardiac fibroblast-to-myofibroblast differentiation and regulates myocardial fibrosis and explored the molecular mechanism underpinning its effects in this process. Methods and results: Using Dlk1-knockout mice and adenoviral gene delivery, we demonstrate that overexpression of Dlk1 in cardio-fibroblasts resulted in inhibition of fibroblast proliferation and differentiation into myofibroblasts...
April 13, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29667218/early-repolarization-is-involved-in-ventricular-fibrillation-in-patients-with-variant-angina
#20
Tetsuji Shinohara, Hidekazu Kondo, Akira Fukui, Hidefumi Akioka, Yasushi Teshima, Kunio Yufu, Mikiko Nakagawa, Naohiko Takahashi
BACKGROUND: Variant angina (VA) is caused by reversible coronary artery spasm, which is characterized by chest pain with ST segment elevations on a standard 12-lead electrocardiogram (ECG) at rest. VA attack often causes lethal ventricular arrhythmia. The early repolarization (ER) pattern is associated with ventricular fibrillation (VF). However, whether the ER pattern is involved in VF in patients with VA is not known. We investigated the association between the ER pattern and VF in patients with VA...
April 17, 2018: Pacing and Clinical Electrophysiology: PACE
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