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https://www.readbyqxmd.com/read/28406436/modeling-infrared-signal-reflections-to-characterize-indoor-multipath-propagation
#1
Álvaro De-La-Llana-Calvo, José Luis Lázaro-Galilea, Alfredo Gardel-Vicente, David Rodríguez-Navarro, Ignacio Bravo-Muñoz, Georgios Tsirigotis, Juan Iglesias-Miguel
In this paper, we propose a model to characterize Infrared (IR) signal reflections on any kind of surface material, together with a simplified procedure to compute the model parameters. The model works within the framework of Local Positioning Systems (LPS) based on IR signals (IR-LPS) to evaluate the behavior of transmitted signal Multipaths (MP), which are the main cause of error in IR-LPS, and makes several contributions to mitigation methods. Current methods are based on physics, optics, geometry and empirical methods, but these do not meet our requirements because of the need to apply several different restrictions and employ complex tools...
April 13, 2017: Sensors
https://www.readbyqxmd.com/read/28359530/analysis-of-the-optimal-sampling-rate-for-state-estimation-in-sensor-networks-with-delays
#2
Miguel Martínez-Rey, Felipe Espinosa, Alfredo Gardel
When addressing the problem of state estimation in sensor networks, the effects of communications on estimator performance are often neglected. High accuracy requires a high sampling rate, but this leads to higher channel load and longer delays, which in turn worsens estimation performance. This paper studies the problem of determining the optimal sampling rate for state estimation in sensor networks from a theoretical perspective that takes into account traffic generation, a model of network behaviour and the effect of delays...
March 27, 2017: ISA Transactions
https://www.readbyqxmd.com/read/28348591/microbiological-sealing-analysis-of-a-tapered-connection-and-external-hexagon-system
#3
Gardel Nepomuceno Costa, Elizabeth Ferreira Martinez, Aluísio Martins de Oliveira Ruellas, Daiane Cristina Peruzzo, Júlio Cesar Joly, Marcelo Henrique Napimoga
Considering the variety of implant connection systems available in the market and the contrasting literature regarding tapered connection systems in terms of bacterial leakage, the aim of this in vitro study was to compare the effectiveness of the bacterial seal at the implant/abutment interface between an external hexagon and a tapered connection system. Twelve sets of indexed tapered connection components and twelve sets of external hexagon connection components were used for microbiological analysis. In addition, for each model, an implant with its respective prosthetic abutment was used as a negative control and another as a positive control of microbial contamination...
2017: International Journal of Dentistry
https://www.readbyqxmd.com/read/28256617/cholesterol-depletion-impairs-contractile-machinery-in-neonatal-rat-cardiomyocytes
#4
Barbara Hissa, Patrick W Oakes, Bruno Pontes, Guillermina Ramírez-San Juan, Margaret L Gardel
Cholesterol regulates numerous cellular processes. Depleting its synthesis in skeletal myofibers induces vacuolization and contraction impairment. However, little is known about how cholesterol reduction affects cardiomyocyte behavior. Here, we deplete cholesterol by incubating neonatal cardiomyocytes with methyl-beta-cyclodextrin. Traction force microscopy shows that lowering cholesterol increases the rate of cell contraction and generates defects in cell relaxation. Cholesterol depletion also increases membrane tension, Ca(2+) spikes frequency and intracellular Ca(2+) concentration...
March 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28228548/contact-guidance-requires-spatial-control-of-leading-edge-protrusion
#5
G R Ramirez-San Juan, P W Oakes, M L Gardel
In vivo, geometric cues from the extracellular matrix (ECM) are critical for the regulation of cell shape, adhesion, and migration. During contact guidance, the fibrillar architecture of the ECM promotes an elongated cell shape and migration along the fibrils. The subcellular mechanisms by which cells sense ECM geometry and translate it into changes in shape and migration direction are not understood. Here we pattern linear fibronectin features to mimic fibrillar ECM and elucidate the mechanisms of contact guidance...
April 15, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/28217401/presence-of-arachidonoyl-carnitine-is-associated-with-adverse-cardiometabolic-responses-in-hypertensive-patients-treated-with-atenolol
#6
Liming Weng, Yan Gong, Jeffrey Culver, Stephen J Gardell, Christopher Petucci, Alison M Morse, Reginald F Frye, Stephen T Turner, Arlene Chapman, Eric Boerwinkle, John Gums, Amber L Beitelshees, Peggy R Borum, Julie A Johnson, Timothy J Garrett, Lauren M McIntyre, Rhonda M Cooper-DeHoff
INTRODUCTION: Atenolol, a commonly prescribed β blocker for hypertension, is also associated with adverse cardiometabolic effects such as hyperglycemia and dyslipidemia. Knowledge of the mechanistic underpinnings of these adverse effects of atenolol is incomplete. OBJECTIVE: We sought to identify biomarkers associated with risk for these untoward effects of atenolol. We measured baseline blood serum levels of acylcarnitines (ACs) that are involved in a host of different metabolic pathways, to establish associations with adverse cardiometabolic responses after atenolol treatment...
October 2016: Metabolomics: Official Journal of the Metabolomic Society
https://www.readbyqxmd.com/read/28202730/liquid-behavior-of-cross-linked-actin-bundles
#7
Kimberly L Weirich, Shiladitya Banerjee, Kinjal Dasbiswas, Thomas A Witten, Suriyanarayanan Vaikuntanathan, Margaret L Gardel
The actin cytoskeleton is a critical regulator of cytoplasmic architecture and mechanics, essential in a myriad of physiological processes. Here we demonstrate a liquid phase of actin filaments in the presence of the physiological cross-linker, filamin. Filamin condenses short actin filaments into spindle-shaped droplets, or tactoids, with shape dynamics consistent with a continuum model of anisotropic liquids. We find that cross-linker density controls the droplet shape and deformation timescales, consistent with a variable interfacial tension and viscosity...
February 28, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28092558/discriminant-context-information-analysis-for-post-ranking-person-re-identification
#8
Jorge Garcia, Niki Martinel, Alfredo Gardel, Ignacio Bravo, Gian Luca Foresti, Christian Micheloni
Existing approaches for person re-identification are mainly based on creating distinctive representations or on learning optimal metrics. The achieved results are then provided in form of a list of ranked matching persons. It often happens that the true match is not ranked first but it is in the first positions. This is mostly due to the visual ambiguities shared between the true match and other "similar" persons. At the current state, there is a lack of a study of such visual ambiguities which limit the re-identification performance within the first ranks...
January 16, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/28004382/help-to-go-t-cells-transfer-cd40l-to-antigen-presenting-b-cells
#9
Michael L Dustin
Most immune cell communication takes place by intercellular transfer of cytokines or the contact-dependent interaction of surface receptors in immunological synapses. In this issue of the European Journal of Immunology, Gardell and Parker (Eur. J. Immunol. 2016, X, XXX-XXX) point to a new, hybrid mechanism for Th1-cell delivery of help to B cells, based on contact-dependent CD40L transfer. The transfer process and its specificity are both cell contact dependent and antigen dependent. CD40 expression is also required on the B-cell surface to capture the CD40L presented by the Th1 cell...
December 22, 2016: European Journal of Immunology
https://www.readbyqxmd.com/read/27815158/exogenous-iodide-ameliorates-perchlorate-induced-thyroid-phenotypes-in-threespine-stickleback
#10
Alison M Gardell, Frank A von Hippel, Elise M Adams, Danielle M Dillon, Ann M Petersen, John H Postlethwait, William A Cresko, C Loren Buck
Perchlorate is a ubiquitous environmental contaminant that has widespread endocrine disrupting effects in vertebrates, including threespine stickleback (Gasterosteus aculeatus). The target of perchlorate is thyroid tissue where it induces changes in the organization, activation, and morphology of thyroid follicles and surrounding tissues. To test the hypothesis that some phenotypes of perchlorate toxicity are not mediated by thyroid hormone, we chronically exposed stickleback beginning at fertilization to perchlorate (10, 30, 100ppm) or control water with and without supplementation of either iodide or thyroxine (T4)...
March 1, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/27792180/erratum-rodr%C3%A3-guez-navarro-d-et-al-mathematical-model-and-calibration-procedure-of-a-psd-sensor-used-in-local-positioning-systems-sensors-2016-16-1484
#11
David Rodríguez-Navarro, José Luis Lázaro-Galilea, Ignacio Bravo-Muñoz, Alfredo Gardel-Vicente, Francisco Domingo-Perez, Georgios Tsirigotis
n/a.
October 26, 2016: Sensors
https://www.readbyqxmd.com/read/27782384/use-of-ion-chromatography-mass-spectrometry-for-targeted-metabolite-profiling-of-polar-organic-acids
#12
Chris Petucci, Andrew Zelenin, Jeffrey A Culver, Meghan Gabriel, Ken Kirkbride, Terri T Christison, Stephen J Gardell
Organic acids (OAs) serve as metabolites that play pivotal roles in a host of different metabolic and regulatory pathways. The polar nature of many OAs poses a challenge to their measurement using widely practiced analytical methods. In this study, a targeted metabolomics method was developed using ion chromatography/triple quadrupole mass spectrometry (IC/MS) to quantitate 28 polar OAs with limits of quantitation ranging from 0.25 to 50 μM. The interday assay precisions ranged from 1% to 19%, with accuracies ranging from 82% to 115%...
December 6, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27753080/cd40l-is-transferred-to-antigen-presenting-b-cells-during-delivery-of-t-cell-help
#13
Jennifer L Gardell, David C Parker
The delivery of T-cell help to B cells is antigen-specific, MHC-restricted, and CD40L (CD154) dependent. It has been thought that when a T cell recognizes an antigen-presenting B cell, CD40L expressed on the T-cell surface engages with CD40 on the surface of B cells as long as the cells remain conjugated. By adding fluorescently labeled anti-CD40L antibody during overnight incubation of antigen-presenting B cells with antigen-specific T cells, we discovered that CD40L does not remain on the surface of the T cell, but it is transferred to and endocytosed by B cells receiving T-cell help...
January 2017: European Journal of Immunology
https://www.readbyqxmd.com/read/27649189/mathematical-model-and-calibration-procedure-of-a-psd-sensor-used-in-local-positioning-systems
#14
David Rodríguez-Navarro, José Luis Lázaro-Galilea, Ignacio Bravo-Muñoz, Alfredo Gardel-Vicente, Francisco Domingo-Perez, Georgios Tsirigotis
Here, we propose a mathematical model and a calibration procedure for a PSD (position sensitive device) sensor equipped with an optical system, to enable accurate measurement of the angle of arrival of one or more beams of light emitted by infrared (IR) transmitters located at distances of between 4 and 6 m. To achieve this objective, it was necessary to characterize the intrinsic parameters that model the system and obtain their values. This first approach was based on a pin-hole model, to which system nonlinearities were added, and this was used to model the points obtained with the nA currents provided by the PSD...
September 15, 2016: Sensors
https://www.readbyqxmd.com/read/27338414/optimization-of-the-coverage-and-accuracy-of-an-indoor-positioning-system-with-a-variable-number-of-sensors
#15
Francisco Domingo-Perez, Jose Luis Lazaro-Galilea, Ignacio Bravo, Alfredo Gardel, David Rodriguez
This paper focuses on optimal sensor deployment for indoor localization with a multi-objective evolutionary algorithm. Our goal is to obtain an algorithm to deploy sensors taking the number of sensors, accuracy and coverage into account. Contrary to most works in the literature, we consider the presence of obstacles in the region of interest (ROI) that can cause occlusions between the target and some sensors. In addition, we aim to obtain all of the Pareto optimal solutions regarding the number of sensors, coverage and accuracy...
2016: Sensors
https://www.readbyqxmd.com/read/27136562/analysis-and-calibration-of-sources-of-electronic-error-in-psd-sensor-response
#16
David Rodríguez-Navarro, José Luis Lázaro-Galilea, Ignacio Bravo-Muñoz, Alfredo Gardel-Vicente, Georgios Tsirigotis
In order to obtain very precise measurements of the position of agents located at a considerable distance using a sensor system based on position sensitive detectors (PSD), it is necessary to analyze and mitigate the factors that generate substantial errors in the system's response. These sources of error can be divided into electronic and geometric factors. The former stem from the nature and construction of the PSD as well as the performance, tolerances and electronic response of the system, while the latter are related to the sensor's optical system...
April 29, 2016: Sensors
https://www.readbyqxmd.com/read/26971062/editorial-overview-cell-architecture
#17
EDITORIAL
Matthieu Piel, Margaret Gardel
No abstract text is available yet for this article.
February 2016: Current Opinion in Cell Biology
https://www.readbyqxmd.com/read/26819376/the-failing-heart-relies-on-ketone-bodies-as-a-fuel
#18
Gregory Aubert, Ola J Martin, Julie L Horton, Ling Lai, Rick B Vega, Teresa C Leone, Timothy Koves, Stephen J Gardell, Marcus Krüger, Charles L Hoppel, E Douglas Lewandowski, Peter A Crawford, Deborah M Muoio, Daniel P Kelly
BACKGROUND: Significant evidence indicates that the failing heart is energy starved. During the development of heart failure, the capacity of the heart to utilize fatty acids, the chief fuel, is diminished. Identification of alternate pathways for myocardial fuel oxidation could unveil novel strategies to treat heart failure. METHODS AND RESULTS: Quantitative mitochondrial proteomics was used to identify energy metabolic derangements that occur during the development of cardiac hypertrophy and heart failure in well-defined mouse models...
February 23, 2016: Circulation
https://www.readbyqxmd.com/read/26467227/effect-of-emersion-immersion-cycles-on-the-elemental-and-isotopic-compositions-of-the-organic-matter-from-surface-sediments-of-an-intertidal-mud-bank-french-guiana-a-preliminary-study
#19
Swanne Gontharet, Luis Felipe Artigas, Olivier Mathieu, Jean Levêque, Marie-Jeanne Milloux, Jacinthe Caillaud, Sylvie Philippe, Sandric Lesourd, Antoine Gardel
RATIONALE: In various marine environments, the combination of elemental ratios and stable isotopic compositions is usually used to trace the sources of organic matter (OM) in sediments. However, in intertidal areas, the sediments might be temporarily exposed to air during a more or less prolonged duration and the impact of this exposure on the latter parameter is unknown. METHODS: The spatial variations of atomic Total Organic Carbon (TOC) and Total Nitrogen (TN) ratios, and δ(13)C and δ(15)N values, were measured on surface sediments of French Guiana, at the beginning and the end of five consecutive days of emersion during equinoctial tides, as well as at the beginning of a new emersion phase after returning to a normal tidal cycle...
November 30, 2015: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/26201596/dna-rendering-of-polyhedral-meshes-at-the-nanoscale
#20
Erik Benson, Abdulmelik Mohammed, Johan Gardell, Sergej Masich, Eugen Czeizler, Pekka Orponen, Björn Högberg
It was suggested more than thirty years ago that Watson-Crick base pairing might be used for the rational design of nanometre-scale structures from nucleic acids. Since then, and especially since the introduction of the origami technique, DNA nanotechnology has enabled increasingly more complex structures. But although general approaches for creating DNA origami polygonal meshes and design software are available, there are still important constraints arising from DNA geometry and sense/antisense pairing, necessitating some manual adjustment during the design process...
July 23, 2015: Nature
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