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https://www.readbyqxmd.com/read/28222080/patient-inspired-research-a-better-way-to-go
#1
(no author information available yet)
Recently, I attended a meeting of the Oncofertility Consortium and had one of those "a-ha" moments that change one's perspective in a very real way. A surgeon from Sweden was talking about uterus transplantations, and she described how these came about. She told a story about one of her colleagues, who was talking to a young woman who had cervical cancer and had a hysterectomy. The patient asked the physician if they could give her a "new" uterus so that one day she could have a biological child. The physician told her that was not possible and the patient responded, "Why not?" That prompted the physician to start a new field of research, uterine transplantation, that has had some early successes, as well as many failures...
March 1, 2017: Oncology Nursing Forum
https://www.readbyqxmd.com/read/28192253/hematopoietic-stem-cell-transplantation-using-preimplantation-genetic-diagnosis-and-hla-typing-for-hla-matched-sibling-donor-a-turkish-multicenter-study
#2
Emin Kurekci, Alphan Küpesiz, Sema Anak, Gülyüz Öztürk, Orhan Gürsel, Serap Aksoylar, Talia Ileri, Barış Kuşkonmaz, Ibrahim Eker, Mualla Cetin, Gülsün Tezcan Karasu, Zühre Kaya, Tunç Fışgın, Mehmet Ertem, Savaş Kansoy, Mehmet Akif Yeşilipek
Preimplantation genetic diagnosis involves the diagnosis of a genetic disorder in embryos obtained through in vitro fertilization, selection of healthy embryos, and transferring them to the mother's uterus. Preimplantation genetic diagnosis has been used not only to avoid the risk of having an affected child, but also by using HLA matching together, it offers preselection of potential HLA-genoidentical healthy donor progeny for an affected sibling, who requires bone marrow transplantation. Here, we share the hematopoietic stem cell transplantation results of 52 patients with different benign and malign hematological or metabolic diseases or immunodeficiencies, whose donors were their siblings borned with this technique in Turkey since 2008...
February 10, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/28121763/transplantation-of-the-uterus
#3
M Terese Verklan
No abstract text is available yet for this article.
January 2017: Journal of Perinatal & Neonatal Nursing
https://www.readbyqxmd.com/read/28093178/re-one-uterus-bridging-three-generations-first-live-birth-after-mother-to-daughter-uterus-transplantation
#4
Craig Niederberger
No abstract text is available yet for this article.
February 2017: Journal of Urology
https://www.readbyqxmd.com/read/28025841/regulation-of-diapause-in-carnivores
#5
J C Fenelon, P L Lefèvre, A Banerjee, B D Murphy
Embryonic diapause is an evolutionary strategy to ensure that offspring are born when maternal and environmental conditions are optimal for survival. In many species of carnivores, obligate embryonic diapause occurs in every gestation. In mustelids, the regulation of diapause and reactivation is influenced by photoperiod, which then acts to regulate the secretion of pituitary prolactin. Prolactin in turn regulates ovarian steroid function. Reciprocal embryo transplant studies indicate that this state of embryonic arrest is conferred by uterine conditions and is presumed to be due to a lack of specific factors necessary for continued development...
December 27, 2016: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/27995397/uterine-tissue-engineering-and-the-future-of-uterus-transplantation
#6
Mats Hellström, Sara Bandstein, Mats Brännström
The recent successful births following live donor uterus transplantation are proof-of-concept that absolute uterine factor infertility is a treatable condition which affects several hundred thousand infertile women world-wide due to a dysfunctional uterus. This strategy also provides an alternative to gestational surrogate motherhood which is not practiced in most countries due to ethical, religious or legal reasons. The live donor surgery involved in uterus transplantation takes more than 10 h and is then followed by years of immunosuppressive medication to prevent uterine rejection...
December 19, 2016: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/27941441/live-donors-of-the-initial-observational-study-of-uterus-transplantation-psychological-and-medical-follow-up-until-1-year-after-surgery-in-the-9-cases
#7
Niclas Kvarnström, Stina Järvholm, Liza Johannesson, Pernilla Dahm-Kähler, Michael Olausson, Mats Brännström
BACKGROUND: The first prospective observational study of uterus transplantation was initiated in 2013 with live donation to 9 women with absolute uterine factor infertility. We explored the medical complications and psychosocial wellbeing of the donors during the first postoperative year. METHODS: Complications were registered and graded according to the Clavien-Dindo (C-D) classification. Symptoms related to the surgery were registered. Data on length of hospital stay, sick leave, socioeconomic parameters, and life events were obtained...
March 2017: Transplantation
https://www.readbyqxmd.com/read/27915038/intrauterine-administration-of-hcg-activated-autologous-human-peripheral-blood-mononuclear-cells-pbmc-promotes-live-birth-rates-in-frozen-thawed-embryo-transfer-cycles-of-patients-with-repeated-implantation-failure
#8
Saijiao Li, Jing Wang, Yan Cheng, Danni Zhou, Tailang Yin, Wangming Xu, Nan Yu, Jing Yang
Recurrent implantation failure refers to unsuccessful implantation after repeated transfers of morphologically good quality embryos into a normal uterus. Recently, accumulating evidence has suggested that local immune cells at the implantation site have actively contributed to embryo implantation. Our aim was to study the effects of intrauterine administration of hCG-activated autologous human PBMC on clinical pregnancy, implantation rates and live birth rate of patients who received frozen/thawed embryo transfer...
November 27, 2016: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/27873528/transplantation-of-vascularized-composite-allografts-review-of-current-knowledge
#9
M Molitor
Transplantation in reconstructive surgery has been performed for more than 20 years, although the official beginning of these procedures is considered the first successful transplantation of the hand in 1998. The original name "Composite Tissue Transplantation" has been used less frequently; more common is the term "Vascularized Composite Allotransplant", which better describes the basis of the procedure. There have been so far approximately 180 transplantations performed, the exact number is difficult to find...
December 0: Acta Chirurgiae Plasticae
https://www.readbyqxmd.com/read/27868389/monitoring-of-human-uterus-transplantation-with-cervical-biopsies-a-provisional-scoring-system-for-rejection
#10
J Mölne, V Broecker, J Ekberg, O Nilsson, P Dahm-Kähler, M Brännström
Until now, absolute uterine factor infertility has been the major untreatable form of female infertility. Uterus transplantation has recently proven to be the first successful treatment for absolute uterine factor infertility, with demonstration of live births. In this study, live donation uterus transplantation was performed in nine women. In total, 163 cervical biopsies (149 protocol, 14 follow-up) were taken to detect histopathological signs of rejection. Based on experience from animal experiments, we used a three-grade scoring system to evaluate biopsies systematically...
November 21, 2016: American Journal of Transplantation
https://www.readbyqxmd.com/read/27814762/risk-of-adverse-pregnancy-and-perinatal-outcomes-after-high-technology-infertility-treatment-a-comprehensive-systematic-review
#11
REVIEW
Stefano Palomba, Roy Homburg, Susanna Santagni, Giovanni Battista La Sala, Raoul Orvieto
In the literature, there is growing evidence that subfertile patients who conceived after infertility treatments have an increased risk of pregnancy and perinatal complications and this is particularly true for patients who conceived through use of high technology infertility treatments. Moreover, high technology infertility treatments include many concomitant clinical and biological risk factors. This review aims to summarize in a systematic fashion the current evidence regarding the relative effect of the different procedures for high technology infertility treatments on the risk of adverse pregnancy and perinatal outcome...
November 4, 2016: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/27786258/surgical-technique-for-allogeneic-uterus-transplantation-in-macaques
#12
Hideaki Obara, Iori Kisu, Yojiro Kato, Yohei Yamada, Kentaro Matsubara, Katsura Emoto, Masataka Adachi, Yusuke Matoba, Kiyoko Umene, Yuya Nogami, Kouji Banno, Hideaki Tsuchiya, Iori Itagaki, Ikuo Kawamoto, Takahiro Nakagawa, Hirohito Ishigaki, Yasushi Itoh, Kazumasa Ogasawara, Yoko Saiki, Shin-Ichi Sato, Kenshi Nakagawa, Takashi Shiina, Daisuke Aoki, Yuko Kitagawa
No study has reported an animal model of uterus transplantation (UTx) using cynomolgus macaques. We aimed to establish a surgical technique of allogeneic UTx assuming the recovery of a uterus from a deceased donor in cynomolgus macaques. Four allogeneic UTxs were performed in female cynomolgus macaques. Donor surgeries comprised en bloc recovery of organs with iliac vessels on both sides, and/or abdominal aorta/vena cava after sufficient perfusion from one femoral artery or external iliac artery. Before perfusion, 150 mL of whole blood was obtained from the donor for subsequent blood transfusion to the recipient...
October 27, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27774233/other-women-s-wombs-uterus-transplants-and-gestational-surrogacy
#13
John A Robertson
The birth of a child after uterus transplant from a living donor in Sweden in October, 2013 has spurred reproductive and transplant physicians in Europe and North America to investigate whether uterus transplants, from living or cadaveric donors, will be a safe and effective therapy for women with uterine insufficiency. While progress with uterus transplant depends on medical factors, there are also important ethical and legal concerns. Uterus transplant is essential for women without access to surrogacy. It may also be sought by infertile women who dislike surrogacy...
April 2016: Journal of Law and the Biosciences
https://www.readbyqxmd.com/read/27754594/living-donor-uterus-transplant-and-surrogacy-ethical-analysis-according-to-the-principle-of-equipoise
#14
G Testa, E C Koon, L Johannesson
The uterus is the most recent addition to the list of organs that can be successfully transplanted in humans. This article analyzes living donor uterus transplantation according to the ethical principle of equipoise. A comparison is made between living donor uterus transplantation and gestational surrogate motherhood. Both are solutions to absolute uterine infertility that allow the transfer of genetic material from intended parents to a child. The analysis concludes that living donor uterus transplantation does not violate the ethical principle of equipoise and should be considered an ethically acceptable solution to absolute uterine infertility...
October 18, 2016: American Journal of Transplantation
https://www.readbyqxmd.com/read/27720095/uterine-transplants-in-the-canadian-setting-a-theoretical-framework
#15
Jacques Balayla
The uterine transplant is an innovative surgical procedure whereby a healthy uterus is transplanted into a woman with uterine factor infertility (UFI) for the purpose of procreation. Twelve uterine transplants have been attempted in the world in the last two decades, and five have led to viable births. While uterine transplantation is still in its experimental stages, it remains unclear whether Canadian centres plan to attempt the procedure in the near future. Herein, I raise several observations that are specific to the Canadian setting and apply the Montreal Criteria for the Ethical Feasibility of Uterine Transplantation to determine whether there is fertile ground for a uterine transplantation program to be adopted in Canada...
October 2016: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/27716570/ectopic-pregnancy-in-simultaneous-pancreas-kidney-transplantation-a-case-report
#16
Shinji Yamamoto, Maria Nelander
INTRODUCTION: We present a case report of ectopic pregnancy (EP) after simultaneous pancreas-kidney transplantation (SKPTx). PRESENTATION OF CASE: A 33-year-old female status post SKPTx suddenly got abdominal pain in the lower level. She had high human chorionic Gonadotropin test. Ultrasonography revealed that there was no fetus in the uterus but a dilated right fallopian tube, which strongly suggested ectopic pregnancy. An emergency operation was performed and a dilated right side uterine tube was found with adhesions to her transplant...
2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27664218/autologous-menstrual-blood-derived-stromal-cells-transplantation-for-severe-asherman-s-syndrome
#17
Jichun Tan, Pingping Li, Qiushi Wang, Yaxuan Li, Xiaoni Li, Dongni Zhao, Xiaoyan Xu, Lin Kong
STUDY QUESTION: Does autologous transplantation of menstrual blood-derived stromal cells (menSCs) regenerate endometrium to support pregnancy in patients with severe Asherman's syndrome (AS)? SUMMARY ANSWER: Autologous menSCs transplantation significantly increases endometrial thickness (ET) for women with severe AS. WHAT IS KNOWN ALREADY: AS is a major cause of secondary infertility in women. Cell transplantation has been tried in a few clinical cases with encouraging results...
September 22, 2016: Human Reproduction
https://www.readbyqxmd.com/read/27650562/deceased-donor-uterus-retrieval-the-first-czech-experience
#18
J Froněk, L Janousek, R Chmel
INTRODUCTION: Uterus transplantation is the youngest solid organ transplantation described in the literature. This procedure is the only treatment method for congenital or acquired Absolute Uterine Factor Infertility. METHOD: The method is not recognised as standard clinical care yet, there were only some 13 cases performed worldwide so far. There is only one clinical trial worldwide, which has proven both feasibility and also healthy child delivery. RESULTS: Czech Republic Ministry of Health permitted the uterus transplant clinical trial in 2015...
December 0: Rozhledy V Chirurgii: Měsíčník Československé Chirurgické Společnosti
https://www.readbyqxmd.com/read/27640423/uterus-human-leucocyte-antigen-expression-in-the-perspective-of-transplantation
#19
Tristan Gauthier, Matthieu Filloux, Angelique Guillaudeau, Marie Essig, Romain Bibes, Adam Fodil Pacha, Pascal Piver, Yves Aubard, Pierre Marquet, Mireille Drouet
AIM: To describe class I and II human leucocyte antigen (HLA) expression using different uterine tissues in the perspective of uterus transplantation. METHODS: Human uterine tissues were obtained from 12 women who had undergone hysterectomy for the treatment of benign disease. HLA class I and HLA-antigen D related (DR) expression were assessed via immunochemistry. HLA class I expression in the uterus was compared with expression in other organs and tissues, including kidney and myocardium samples...
December 2016: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/27638900/uterus-transplantation-from-animal-models-through-the-first-heart-beating-pregnancy-to-the-first-human-live-birth
#20
REVIEW
Omer Ozkan, Nasuh Utku Dogan, Ozlenen Ozkan, Inanc Mendilcioglu, Selen Dogan, Batu Aydinuraz, Mehmet Simsek
Absolute uterine factor infertility affects 3-5% of the general population, and unfortunately this condition is untreatable. There are some available options, including surrogacy or adoption, but neither of these suits each and every woman who desires to have her own genetic child. With recent advances in surgery and transplant immunology, uterus transplantation may be a source of hope for these women with uterine infertility. In the last decade, a number of animal species including rats, mice, rabbits, pigs, sheep, and primates have been used as experimental models, and pregnancies were achieved in some of these...
July 2016: Women's Health
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