keyword
MENU ▼
Read by QxMD icon Read
search

mirna glioma

keyword
https://www.readbyqxmd.com/read/28731180/mir-216b-inhibits-glioma-cell-migration-and-invasion-through-suppression-of-foxm1
#1
Tingting Zhang, Guangtao Ma, Yan Zhang, Hongda Huo, Yuqian Zhao
MicroRNAs (miRNAs) play a vital role in tumour biological and pathologic processes. In the present study, we aimed to detect the expression and biological role of miR-216b in glioma. Our data showed that miR-216b was significantly downregulated in human glioma tissues and cells. Ectopic expression of miR-216b inhibited the proliferation and invasion of U87 and U251 cells and suppressed the growth of xenograft tumours in vivo. Bioinformatic and luciferase reporter analyses identified Forkhead box protein M1 (FoxM1) as a direct target of miR-216b...
July 17, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28724215/melatonin-inhibits-proliferation-and-invasion-via-repression-of-mirna-155-in-glioma-cells
#2
Junyi Gu, Zhongsheng Lu, Chenghong Ji, Yuchao Chen, Yuzhao Liu, Zhe Lei, Longqiang Wang, Hong-Tao Zhang, Xiangdong Li
Melatonin, an indolamine mostly synthesized in the pineal gland, exerts the anti-cancer effect by various mechanisms in glioma cells. Our previous study showed that miR-155 promoted glioma cell proliferation and invasion. However, the question of whether melatonin may inhibit glioma by regulating miRNAs has not yet been addressed. In this study, we found that melatonin (100μM, 1μM and 1nM) significantly inhibited the expression of miR-155 in human glioma cell lines U87, U373 and U251. Especially, the lowest expression of miR-155 was detected in 1μM melatonin-treated glioma cells...
July 14, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28714015/mir-142-inhibits-the-migration-and-invasion-of-glioma-by-targeting-rac1
#3
Wenyi Qin, Xiaofeng Rong, Jiangchuan Dong, Chao Yu, Juan Yang
Increasing evidence has shown that aberrant microRNAs (miRNAs) are implicated in tumorigenesis and tumor progression by regulating oncogenes or tumor suppressors. Dysregulation of miR-142 has been reported in multiple tumors. However, its clinical roles and underlying mechanism in glioma remain to be elucidated. In the present study, we found that the expression of miR-142 was significantly downregulated in both glioma tissues and cell lines by qRT-PCR. Clinical analysis revealed that decreased miR-142 was markedly associated with advanced World Health Organization (WHO) grade...
July 13, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28704799/microrna-539-inhibits-glioma-cell-proliferation-and-invasion-by-targeting-dixdc1
#4
Junjie Quan, Jianqiang Qu, Le Zhou
Dysregulation of microRNAs (miRNAs) has been suggested to contribute to malignant progression of glioma. Previous studies have demonstrated that miR-539 is dysregulated in malignant progression of cancers. However, the potential role and mechanism of miR-539 in the progression of glioma remains unclear. In this study, we aimed to investigate the expression status and functional significance of miR-539 in glioma. We found that miR-539 expression was significantly decreased in glioma cell lines and tissues. Overexpression of miR-539 markedly inhibited glioma cell proliferation and invasion, while miR-539 suppression exhibited the opposite effect...
July 10, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28698530/the-role-of-mirnas-in-angiogenesis-invasion-and-metabolism-and-their-therapeutic-implications-in-gliomas
#5
REVIEW
Sasha Beyer, Jessica Fleming, Wei Meng, Rajbir Singh, S Jaharul Haque, Arnab Chakravarti
MicroRNAs (miRNAs) are small, non-coding, endogenous RNA molecules that function in gene silencing by post-transcriptional regulation of gene expression. The dysregulation of miRNA plays a pivotal role in cancer tumorigenesis, including the development and progression of gliomas. Their small size, stability and ability to target multiple oncogenes have simultaneously distinguished miRNAs as attractive candidates for biomarkers and novel therapeutic targets for glioma patients. In this review, we summarize the most frequently cited miRNAs known to contribute to gliomagenesis and progression by regulating the defining hallmarks of gliomas, including angiogenesis, invasion, and cell metabolism...
July 10, 2017: Cancers
https://www.readbyqxmd.com/read/28687876/chromosome-21-encoded-micrornas-mrnas-impact-on-down-s-syndrome-and-trisomy-21-linked-disease
#6
P N Alexandrov, M E Percy, Walter J Lukiw
Down's syndrome (DS; also known as trisomy 21; T21) is caused by a triplication of all or part of human chromosome 21 (chr21). DS is the most common genetic cause of intellectual disability attributable to a naturally-occurring imbalance in gene dosage. DS incurs huge medical, healthcare, and socioeconomic costs, and there are as yet no effective treatments for this incapacitating human neurogenetic disorder. There is a remarkably wide variability in the 'phenotypic spectrum' associated with DS; the progression of symptoms and the age of DS onset fluctuate, and there is further variability in the biophysical nature of the chr21 duplication...
July 7, 2017: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/28677773/microrna-342-inhibits-the-progression-of-glioma-by-directly-targeting-pak4
#7
Xianghe Lu, Haowen Wang, Zhipeng Su, Lin Cai, Wenfeng Li
Glioma is an extremely aggressive and lethal type of brain tumour that originates from glial cells. MicroRNA (miRNA) dysregulation has been implicated in the occurrence and progression of many human cancers, including glioma. Thus, some specific miRNAs are potential therapeutic targets for glioma diagnosis, therapy and prognosis. MicroRNA-342 (miR‑342) has been reported to be abnormally expressed in various types of cancer. However, the precise roles of miR‑342 in glioma remain unknown. The present study showed that miR‑342 is relatively downregulated in glioma tissues and cell lines compared with that in adjacent normal tissues and normal human astrocytes...
July 3, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28666797/gas5-suppresses-malignancy-of-human-glioma-stem-cells-via-a-mir-196a-5p-foxo1-feedback-loop
#8
Xihe Zhao, Yunhui Liu, Jian Zheng, Xiaobai Liu, Jiajia Chen, Libo Liu, Ping Wang, Yixue Xue
Glioma stem cells (GSCs) make up highly tumorigenic subpopulations within gliomas, and aberrant expression of GSC genes is a major underlying cause of glioma pathogenesis and treatment failure. The present study characterized the expression and function of long non-coding RNA growth arrest specific 5 (GAS5) in GSCs in order to elucidate the molecular mechanisms by which GAS5 contributes to glioma pathogenesis. We demonstrate that GAS5 suppresses GSC malignancy by binding to miR-196a-5p. miR-196a-5p, an onco-miRNA, stimulates GSC proliferation, migration, and invasion, in addition to reducing levels of apoptosis...
June 27, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28666210/mir-489-inhibits-proliferation-cell-cycle-progression-and-induces-apoptosis-of-glioma-cells-via-targeting-spin1-mediated-pi3k-akt-pathway
#9
Yan Li, Xiaolin Ma, Yanpeng Wang, Guohua Li
microRNA-489 (miR-489), a newly identified tumor-related miRNA, functions as an oncogene or tumor suppressor via regulating growth and metastasis of human cancers. But, the clinical significance, biological function and underlying mechanisms of miR-489 in glioma remain rarely known. Here, we showed that the levels of miR-489 in glioma tissues were notably underexpressed compared to corresponding non-tumor tissues. In accordance, the relative levels of miR-489 were decreased in glioma cell lines compared with NHA cells...
June 27, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28660665/integrated-microrna-and-gene-expression-profiling-reveals-the-crucial-mirnas-in-curcumin-anti-lung-cancer-cell-invasion
#10
Jian-Wei Zhan, De-Min Jiao, Yi Wang, Jia Song, Jin-Hong Wu, Li-Jun Wu, Qing-Yong Chen, Sheng-Lin Ma
BACKGROUND: Curcumin (diferuloylmethane) has chemopreventive and therapeutic properties against many types of tumors, both in vitro and in vivo. Previous reports have shown that curcumin exhibits anti-invasive activities, but the mechanisms remain largely unclear. METHODS: In this study, both microRNA (miRNA) and messenger RNA (mRNA) expression profiles were used to characterize the anti-metastasis mechanisms of curcumin in human non-small cell lung cancer A549 cell line...
June 29, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28658662/microrna-145-induces-apoptosis-of-glioma-cells-by-targeting-bnip3-and-notch-signaling
#11
Yan Du, Juan Li, Tao Xu, Dan-Dan Zhou, Lei Zhang, Xiao Wang
MicroRNAs (miRNAs) are involved in the pathogenesis of various human cancers. Here we show that miR-145 expression is decreased in human glioma samples, rat glioma tissues, and glioma cell lines, while expression of BNIP3 is increased. Over-expression of miR-145 or suppression of BNIP3 induced glioma cell apoptosis. BNIP3 is localized in the nucleus in glioma cells, and miR-145 inhibits BNIP3 expression by binding to the 3' untranslated region of its mRNA. Interestingly, miR-145 and BNIP3 regulate glioma cell apoptosis by modulating Notch signaling...
June 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28656255/low-expression-of-microrna-320b-correlates-with-tumorigenesis-and-unfavorable-prognosis-in-glioma
#12
Qiao-Li Lv, Hong Du, Yan-Ling Liu, Yuang-Tao Huang, Gui-Hua Wang, Xue Zhang, Shu-Hui Chen, Hong-Hao Zhou
Accumulating evidence demonstrates that dysregulated microRNAs (miRNAs) play a critical role in tumorigenesis and progression of various cancers. miR-320b, a member of miR‑320 family, was revealed downregulated in numerous human cancers, including nasopharyngeal carcinoma and colorectal cancer. However, the function of miR‑320b in human glioma remained poorly defined. In this study, we report that miR‑320b was lowly expressed in glioma tissues and cell lines in contrast with controls, being closely correlated with histological malignancy of glioma...
June 28, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28651608/linc00152-promotes-malignant-progression-of-glioma-stem-cells-by-regulating-mir-103a-3p-fezf1-cdc25a-pathway
#13
Mingjun Yu, Yixue Xue, Jian Zheng, Xiaobai Liu, Hai Yu, Libo Liu, Zhen Li, Yunhui Liu
BACKGROUND: Glioma is one of the most frequent intracranial malignant tumors. LncRNAs have been identified as new modulators in the origination and progression of glioma. METHODS: Quantitative real-time PCR were conducted to evaluate the expression of linc00152 and miRNA-103a-3p in glioma tissues and cells. Western blot were used to determine the expression of FEZF1 and CDC25A in glioma tissues and cells. Stable knockdown of linc00152 or over-expression of miR-103a-3p in glioma stem cells (GSCs) were established to explore the function of linc00152 and miR-103a-3p in GSCs...
June 26, 2017: Molecular Cancer
https://www.readbyqxmd.com/read/28627653/mir-543-functions-as-a-tumor-suppressor-in-glioma-in-vitro-and-in-vivo
#14
Liang Xu, Ju Yu, Zhongyong Wang, Qing Zhu, Wenjie Wang, Qing Lan
Gliomas are the most common primary central nervous system tumors and account for approximately 80% of malignant brain tumors. MicroRNAs (miRNAs) are a class of small non-coding, regulatory RNA molecules that mediate the expression levels of specific proteins. As a member of the miRNA family, miR-543 plays a tumor suppressive or an oncogenic role in different types of tumors. However, the expression and role of miR-543 in glioma remain unknown. In the present study, the expression level of miR-543 in glioma cell lines and tissues was investigated...
June 12, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28617546/down-expression-of-mir-373-predicts-poor-prognosis-of-glioma-and-could-be-a-potential-therapeutic-target
#15
S-Y Jing, S-Q Jing, L-L Liu, L-F Xu, F Zhang, J-L Gao
OBJECTIVE: MicroRNAs (miRNAs) are epigenetic regulators of gene expression, and their deregulation plays an important role in human cancer, including glioma. The main objective of this work was to investigate the expression level of miR-373 and its clinical significance in glioma. PATIENTS AND METHODS: The expression levels of miR-373 in glioma tissues and non-neoplastic brain tissues were measured by the qRT-PCR assay. Patients were divided into two groups based on the median miR-373 expression...
May 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28586047/identification-and-functional-analysis-of-the-risk-micrornas-associated-with-cerebral-low-grade-glioma-prognosis
#16
Xinrui Liu, Bin Song, Shanji Li, Nan Wang, Hongfa Yang
Low-grade gliomas (LGGs) are associated with neurological disability. The present study used microRNA (miRNA) expression profiles to identify risk miRNAs for potential prognosis of cerebral LGGs. miRNA expression profiles and clinical data from 408 patients with cerebral LGGs were obtained from the Cancer Genome Atlas database. Risk miRNAs were identified by plotting Kaplan‑Meier curves and Cox proportional hazard regression analysis with the survival and KMsurv packages in R. A regulatory network of miRNA‑targets was constructed, followed by gene ontology (GO) function and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis using the Database for Annotation, Visualization and Integrated Discovery...
August 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28583401/mir-873-suppresses-h9c2-cardiomyocyte-proliferation-by-targeting-gli1
#17
REVIEW
Jing-Shu Zhang, Yue Zhao, Yuan Lv, Pei-Yan Liu, Jun-Xia Ruan, Yue-Ling Sun, Tian-Xing Gong, Nan Wan, Guang-Rong Qiu
MicroRNAs (miRNAs) are a class of endogenous, non-coding small RNAs that regulate the expression of target genes. Previous studies have suggested that miRNAs are key regulators in cardiovascular systems. This study investigated the role of miR-873 in H9C2 cardiomyocytes by targeting glioma-associated oncogene 1 (GLI1). miR-873 was significantly up-regulated in serum samples from congenital heart disease (CHD) patients compared with those from normal individuals. Furthermore, miR-873 over-expression suppressed H9C2 proliferation and induced cell cycle arrest...
June 2, 2017: Gene
https://www.readbyqxmd.com/read/28577032/advancements-in-the-study-of-mirna-regulation-during-the-cell-cycle-in-human-pituitary-adenomas
#18
REVIEW
Ting Zhang, Zijiang Yang, Heng Gao
Pituitary adenomas (PAs), single-clone adenomas arising from pituitary gland cells, comprise one of the most frequent tumors found in the sella region. The prevalence of PAs is approximately 15%, third only after gliomas and meningioma among intracranial tumors. Autopsy and radiological analysis found that the incidence of PAs is approximately 22.5%. Most PAs are benign, although a few are malignant. Just 0.1% of patients with PAs develop pituitary carcinoma. However, owing to mass effects and unregulated secretion of pituitary hormones, PAs also lead to serious morbidity...
June 2, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28576488/intronic-mirna-641-controls-its-host-gene-s-pathway-pi3k-akt-and-this-relationship-is-dysfunctional-in-glioblastoma-multiforme
#19
Ludwig Christian Hinske, Jens Heyn, Max Hübner, Jessica Rink, Simon Hirschberger, Simone Kreth
MicroRNAs have established their role as important regulators of the epigenome. A considerable number of human miRNA genes are found in intronic regions of protein-coding host genes, in many cases adopting their regulatory circuitry. However, emerging evidence foreshadows an unprecedented importance for this relationship: Intronic miRNAs may protect the cell from overactivation of the respective host pathway, a setting that may trigger tumor development. AKT2 is a well-known proto-oncogene central to the PI3K/AKT pathway...
May 30, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28536644/microrna-548c-3p-inhibits-t98g-glioma-cell-proliferation-and-migration-by-downregulating-c-myb
#20
Jianyi Lu, Min Zhang, Xiao Yang, Tong Cui, Jinpo Dai
MicroRNAs (miRNAs/miRs) are short non-coding RNAs (between 20 and 22 nucleotides) that regulate gene expression by binding to the 3'-untranslated region of target mRNA, and preventing protein translation or inducing mRNA destabilization. miRNAs are predicted to target ~60% of all mRNAs, therefore providing a marked degree of regulation of a number of cellular processes. In the present study, the expression of miR-548c-3p was determined by reverse transcription-quantitative polymerase chain reaction analysis and demonstrated to be markedly downregulated in clinical malignant glioma tissues and the glioma T98G cell line compared with normal human brain tissue...
May 2017: Oncology Letters
keyword
keyword
39282
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"